3KXVA

Structure of complement factor h variant q1139a
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
125
structure length
125
Chain Sequence
TGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCANLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Complement factor H
publication title Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d
pubmed doi rcsb
source organism Homo sapiens
molecule tags Immune system
total genus 25
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2009-12-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3kxvA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3kxvA02
4AYMA 3KZJA 1LY2A 1E8BA 1H03P 1HFIA 3GOVA 3T5OA 3NFPI 1OK2A 4WJG2 1OK1A 1OK9A 2EC3A 1OK3A 2LOJA 1GKNA 3RJ3D 1VVDA 2YRAA 1OJWA 2UWNA 4ZH1D 3R62A 4JHSA 2XWBF 2EHFA 1GPZA 2CG6A 2KMSA 2KRIA 4AYEA 1HFHA 3ZD1A 4PZ5A 1Z92B 2MCZA 2XQWC 3IX0A 1HCCA 1QGBA 2V8EA 1H04P 2O39C 1GKGA 2CG7A 2IZ3A 2JGWA 1QO6A 1PPQA 4B2SA 4YNXA 2RKZA 1SS2A 4A5WB 2CKUA 4LOTA 3SW0X 5JPMG 1SRZA 4B2RA 1TPMA 2XRBA 1G4GA 4C16A 1QUBA 2W80A 2WIIC 1GHQB 2RL0A 3OEDC 4F4OC 4AYDA 1E5GA 2XWJI 4LOSA 1ELVA 5I0QB 1U5MA 2BZMA 2G7IA 3IU3I 3GXEA 4K12A 1C1ZA 1CKLA 2IZ4A 2A55A 4IGDA 1UOTP 3CALA 4CSYA 1MD8A 1E88A 1H2QP 3M7PA 4MUCA 3ZRZA 2RKYA 2QY0A 1Q3XA 4FXGG 3EJHA 4KKDA 3INBC 1VVCA 4DJZA 2RLPA 1H2PP 2YBYA 3KXVA 1FBRA 1MD7A 1OJVA 4AYIA 2MCYA 1O9AA 2RLQA 1G4FA 5FO8C 2ERJA 3MQLA 3TVJA 1TPNA 2JGXA 1TPGA 5HYPA 5HZPB 5HYUB 1OJYA 2JRAA 3L89M 3O8EB 2B5ID 3OXUD 1ZJKA 3OP8A 2XRDA 3ZD2A 4J38B 1NWVA 4ONTD 5HYTB 3ERBA 2W81A
chains in the Genus database with same CATH superfamily
4AYMA 3KZJA 1LY2A 1E8BA 1H03P 1HFIA 2X2ZA 3GOVA 3T5OA 3NFPI 1OK2A 4WJG2 1OK1A 1OK9A 2EC3A 1OK3A 2LOJA 4BWCA 5DN4A 1GKNA 3RJ3D 1VVDA 2Y8TA 2YRAA 1OJWA 2UWNA 4N7EA 2Y8RA 4ZH1D 3ZLDA 3R62A 4JHSA 2XWBF 2EHFA 1GPZA 2CG6A 2KMSA 2KRIA 4AYEA 1HFHA 3ZD1A 4PZ5A 1Z92B 2MCZA 2XQWC 3IX0A 1HCCA 1QGBA 2V8EA 1H04P 2O39C 1GKGA 2CG7A 2IZ3A 2JGWA 4APLA 1QO6A 1PPQA 4B2SA 4YNXA 2RKZA 1SS2A 4A5WB 3FGTA 2CKUA 4LOTA 1RLHA 5JPMG 1SRZA 3SW0X 4B2RA 1TPMA 2XRBA 1G4GA 4C16A 1QUBA 2W80A 2WIIC 1GHQB 2RL0A 3OEDC 4F4OC 4AYDA 1E5GA 2XWJI 4LOSA 3WSXA 2I2LA 1ELVA 5I0QB 1U5MA 2BZMA 2Y8SA 2G7IA 4PO7A 3IU3I 3GXEA 4K12A 1C1ZA 1CKLA 2IZ4A 2A55A 4IGDA 3VWOA 3FGRA 1UOTP 3CALA 4CSYA 1MD8A 1E88A 1H2QP 3M7PA 4MUCA 3ZRZA 2RKYA 2QY0A 3NJAA 1Q3XA 4FXGG 3K3TA 3ZLEA 3EJHA 4KKDA 3INBC 1VVCA 4DJZA 2RLPA 1H2PP 2YBYA 3F6KA 3KXVA 1FBRA 1MD7A 3WSYA 1OJVA 4AYIA 2MCYA 3CI0J 1O9AA 2RLQA 2ZYCA 1G4FA 5FO8C 2ERJA 4MSLA 3MQLA 3TVJA 1TPNA 2JGXA 1TPGA 5HYPA 4YIZA 5HZPB 5HYUB 1OJYA 2JRAA 3L89M 3O8EB 2B5ID 3OXUD 1ZJKA 5DN5A 3OP8A 2XRDA 3ZD2A 4J38B 1NWVA 4ONTD 5HYTB 3ERBA 2W81A
chains in the Genus database with same CATH topology
4AYMA 3KZJA 1LY2A 1E8BA 1H03P 1HFIA 3GOVA 3T5OA 3NFPI 1OK2A 4WJG2 1OK1A 1OK9A 2EC3A 1OK3A 2LOJA 1GKNA 3RJ3D 1VVDA 2YRAA 1OJWA 2UWNA 4ZH1D 3R62A 4JHSA 2XWBF 2EHFA 1GPZA 2CG6A 2KMSA 2KRIA 4AYEA 1HFHA 3ZD1A 4PZ5A 1Z92B 2MCZA 2XQWC 3IX0A 1HCCA 1QGBA 2V8EA 1H04P 2O39C 1GKGA 2CG7A 2IZ3A 2JGWA 1QO6A 1PPQA 4B2SA 4YNXA 2RKZA 1SS2A 4A5WB 2CKUA 4LOTA 3SW0X 5JPMG 1SRZA 4B2RA 1TPMA 2XRBA 1G4GA 4C16A 1QUBA 2W80A 2WIIC 1GHQB 2RL0A 3OEDC 4F4OC 4AYDA 1E5GA 2XWJI 4LOSA 1ELVA 5I0QB 1U5MA 2BZMA 2G7IA 3IU3I 3GXEA 4K12A 1C1ZA 1CKLA 2IZ4A 2A55A 4IGDA 1UOTP 3CALA 4CSYA 1MD8A 1E88A 1H2QP 3M7PA 4MUCA 3ZRZA 2RKYA 2QY0A 1Q3XA 4FXGG 3EJHA 4KKDA 3INBC 1VVCA 4DJZA 2RLPA 1H2PP 2YBYA 3KXVA 1FBRA 1MD7A 1OJVA 4AYIA 2MCYA 1O9AA 2RLQA 1G4FA 5FO8C 2ERJA 3MQLA 3TVJA 1TPNA 2JGXA 1TPGA 5HYPA 5HZPB 5HYUB 1OJYA 2JRAA 3L89M 3O8EB 2B5ID 3OXUD 1ZJKA 3OP8A 2XRDA 3ZD2A 4J38B 1NWVA 4ONTD 5HYTB 3ERBA 2W81A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AYM A;  3KZJ A;  1LY2 A;  1E8B A;  1H03 P;  1HFI A;  3GOV A;  3T5O A;  3NFP I;  1OK2 A;  4WJG 2;  1OK1 A;  1OK9 A;  2EC3 A;  1OK3 A;  2LOJ A;  1GKN A;  3RJ3 D;  1VVD A;  2YRA A;  1OJW A;  2UWN A;  4ZH1 D;  3R62 A;  4JHS A;  2XWB F;  2EHF A;  1GPZ A;  2CG6 A;  2KMS A;  2KRI A;  4AYE A;  1HFH A;  3ZD1 A;  4PZ5 A;  1Z92 B;  2MCZ A;  2XQW C;  3IX0 A;  1HCC A;  1QGB A;  2V8E A;  1H04 P;  2O39 C;  1GKG A;  2CG7 A;  2IZ3 A;  2JGW A;  1QO6 A;  1PPQ A;  4B2S A;  4YNX A;  2RKZ A;  1SS2 A;  4A5W B;  2CKU A;  4LOT A;  3SW0 X;  5JPM G;  1SRZ A;  4B2R A;  1TPM A;  2XRB A;  1G4G A;  4C16 A;  1QUB A;  2W80 A;  2WII C;  1GHQ B;  2RL0 A;  3OED C;  4F4O C;  4AYD A;  1E5G A;  2XWJ I;  4LOS A;  1ELV A;  5I0Q B;  1U5M A;  2BZM A;  2G7I A;  3IU3 I;  3GXE A;  4K12 A;  1C1Z A;  1CKL A;  2IZ4 A;  2A55 A;  4IGD A;  1UOT P;  3CAL A;  4CSY A;  1MD8 A;  1E88 A;  1H2Q P;  3M7P A;  4MUC A;  3ZRZ A;  2RKY A;  2QY0 A;  1Q3X A;  4FXG G;  3EJH A;  4KKD A;  3INB C;  1VVC A;  4DJZ A;  2RLP A;  1H2P P;  2YBY A;  3KXV A;  1FBR A;  1MD7 A;  1OJV A;  4AYI A;  2MCY A;  1O9A A;  2RLQ A;  1G4F A;  5FO8 C;  2ERJ A;  3MQL A;  3TVJ A;  1TPN A;  2JGX A;  1TPG A;  5HYP A;  5HZP B;  5HYU B;  1OJY A;  2JRA A;  3L89 M;  3O8E B;  2B5I D;  3OXU D;  1ZJK A;  3OP8 A;  2XRD A;  3ZD2 A;  4J38 B;  1NWV A;  4ONT D;  5HYT B;  3ERB A;  2W81 A; 
#chains in the Genus database with same CATH topology
 4AYM A;  3KZJ A;  1LY2 A;  1E8B A;  1H03 P;  1HFI A;  2X2Z A;  3GOV A;  3T5O A;  3NFP I;  1OK2 A;  4WJG 2;  1OK1 A;  1OK9 A;  2EC3 A;  1OK3 A;  2LOJ A;  4BWC A;  5DN4 A;  1GKN A;  3RJ3 D;  1VVD A;  2Y8T A;  2YRA A;  1OJW A;  2UWN A;  4N7E A;  2Y8R A;  4ZH1 D;  3ZLD A;  3R62 A;  4JHS A;  2XWB F;  2EHF A;  1GPZ A;  2CG6 A;  2KMS A;  2KRI A;  4AYE A;  1HFH A;  3ZD1 A;  4PZ5 A;  1Z92 B;  2MCZ A;  2XQW C;  3IX0 A;  1HCC A;  1QGB A;  2V8E A;  1H04 P;  2O39 C;  1GKG A;  2CG7 A;  2IZ3 A;  2JGW A;  4APL A;  1QO6 A;  1PPQ A;  4B2S A;  4YNX A;  2RKZ A;  1SS2 A;  4A5W B;  3FGT A;  2CKU A;  4LOT A;  1RLH A;  5JPM G;  1SRZ A;  3SW0 X;  4B2R A;  1TPM A;  2XRB A;  1G4G A;  4C16 A;  1QUB A;  2W80 A;  2WII C;  1GHQ B;  2RL0 A;  3OED C;  4F4O C;  4AYD A;  1E5G A;  2XWJ I;  4LOS A;  3WSX A;  2I2L A;  1ELV A;  5I0Q B;  1U5M A;  2BZM A;  2Y8S A;  2G7I A;  4PO7 A;  3IU3 I;  3GXE A;  4K12 A;  1C1Z A;  1CKL A;  2IZ4 A;  2A55 A;  4IGD A;  3VWO A;  3FGR A;  1UOT P;  3CAL A;  4CSY A;  1MD8 A;  1E88 A;  1H2Q P;  3M7P A;  4MUC A;  3ZRZ A;  2RKY A;  2QY0 A;  3NJA A;  1Q3X A;  4FXG G;  3K3T A;  3ZLE A;  3EJH A;  4KKD A;  3INB C;  1VVC A;  4DJZ A;  2RLP A;  1H2P P;  2YBY A;  3F6K A;  3KXV A;  1FBR A;  1MD7 A;  3WSY A;  1OJV A;  4AYI A;  2MCY A;  3CI0 J;  1O9A A;  2RLQ A;  2ZYC A;  1G4F A;  5FO8 C;  2ERJ A;  4MSL A;  3MQL A;  3TVJ A;  1TPN A;  2JGX A;  1TPG A;  5HYP A;  4YIZ A;  5HZP B;  5HYU B;  1OJY A;  2JRA A;  3L89 M;  3O8E B;  2B5I D;  3OXU D;  1ZJK A;  5DN5 A;  3OP8 A;  2XRD A;  3ZD2 A;  4J38 B;  1NWV A;  4ONT D;  5HYT B;  3ERB A;  2W81 A; 
#chains in the Genus database with same CATH homology
 4AYM A;  3KZJ A;  1LY2 A;  1E8B A;  1H03 P;  1HFI A;  3GOV A;  3T5O A;  3NFP I;  1OK2 A;  4WJG 2;  1OK1 A;  1OK9 A;  2EC3 A;  1OK3 A;  2LOJ A;  1GKN A;  3RJ3 D;  1VVD A;  2YRA A;  1OJW A;  2UWN A;  4ZH1 D;  3R62 A;  4JHS A;  2XWB F;  2EHF A;  1GPZ A;  2CG6 A;  2KMS A;  2KRI A;  4AYE A;  1HFH A;  3ZD1 A;  4PZ5 A;  1Z92 B;  2MCZ A;  2XQW C;  3IX0 A;  1HCC A;  1QGB A;  2V8E A;  1H04 P;  2O39 C;  1GKG A;  2CG7 A;  2IZ3 A;  2JGW A;  1QO6 A;  1PPQ A;  4B2S A;  4YNX A;  2RKZ A;  1SS2 A;  4A5W B;  2CKU A;  4LOT A;  3SW0 X;  5JPM G;  1SRZ A;  4B2R A;  1TPM A;  2XRB A;  1G4G A;  4C16 A;  1QUB A;  2W80 A;  2WII C;  1GHQ B;  2RL0 A;  3OED C;  4F4O C;  4AYD A;  1E5G A;  2XWJ I;  4LOS A;  1ELV A;  5I0Q B;  1U5M A;  2BZM A;  2G7I A;  3IU3 I;  3GXE A;  4K12 A;  1C1Z A;  1CKL A;  2IZ4 A;  2A55 A;  4IGD A;  1UOT P;  3CAL A;  4CSY A;  1MD8 A;  1E88 A;  1H2Q P;  3M7P A;  4MUC A;  3ZRZ A;  2RKY A;  2QY0 A;  1Q3X A;  4FXG G;  3EJH A;  4KKD A;  3INB C;  1VVC A;  4DJZ A;  2RLP A;  1H2P P;  2YBY A;  3KXV A;  1FBR A;  1MD7 A;  1OJV A;  4AYI A;  2MCY A;  1O9A A;  2RLQ A;  1G4F A;  5FO8 C;  2ERJ A;  3MQL A;  3TVJ A;  1TPN A;  2JGX A;  1TPG A;  5HYP A;  5HZP B;  5HYU B;  1OJY A;  2JRA A;  3L89 M;  3O8E B;  2B5I D;  3OXU D;  1ZJK A;  3OP8 A;  2XRD A;  3ZD2 A;  4J38 B;  1NWV A;  4ONT D;  5HYT B;  3ERB A;  2W81 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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