4FXGG

Complement c4 in complex with masp-2
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
145
structure length
145
Chain Sequence
TAHACPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSART
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for activation of the complement system by component C4 cleavage.
pubmed doi rcsb
molecule keywords Complement C4 beta chain
molecule tags Immune system
source organism Homo sapiens
total genus 21
structure length 145
sequence length 145
chains with identical sequence I
ec nomenclature ec 3.4.21.104: Mannan-binding lectin-associated serine protease-2.
pdb deposition date 2012-07-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4fxgG02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4fxgG01
1TPMA 2W81A 4WJG2 1OJWA 2A55A 2XWBF 3OXUD 2O39C 1OK2A 4B2RA 3T5OA 3NFPI 1G4GA 4JHSA 2ERJA 4C16A 4DJZA 1SRZA 1H04P 3GXEA 5HYUB 2RKZA 1HFHA 1NWVA 1VVDA 1OK9A 1ZJKA 4AYMA 5HYPA 2KMSA 2YBYA 2RLPA 1OK1A 2CKUA 5JPMG 1VVCA 3IX0A 2IZ3A 4F4OC 2LOJA 1E8BA 1H03P 2QY0A 4LOSA 2JGXA 1H2PP 3L89M 4LOTA 1E88A 1CKLA 1SS2A 3O8EB 4J38B 4A5WB 3OP8A 2CG6A 1G4FA 4PZ5A 3KXVA 3ZD1A 5I0QB 1MD8A 3GOVA 4IGDA 1TPNA 1QUBA 1HCCA 3EJHA 3RJ3D 1GKGA 4KKDA 3CALA 1C1ZA 4FXGG 3ERBA 1HFIA 4ZH1D 3ZRZA 4AYIA 3M7PA 1OK3A 2KRIA 1LY2A 1O9AA 2RKYA 3IU3I 3INBC 1Q3XA 1QGBA 1PPQA 2XRDA 2CG7A 2WIIC 4MUCA 2JGWA 2V8EA 1OJYA 3MQLA 2MCZA 2XWJI 2MCYA 3R62A 1Z92B 2UWNA 4AYEA 4K12A 2B5ID 3ZD2A 1FBRA 4B2SA 3OEDC 1UOTP 3TVJA 2W80A 4AYDA 2RLQA 1U5MA 2XQWC 2EHFA 1ELVA 3SW0X 2YRAA 5HYTB 2XRBA 1OJVA 4ONTD 1TPGA 2EC3A 2IZ4A 1GPZA 1GHQB 1E5GA 2JRAA 1GKNA 3KZJA 1MD7A 2BZMA 2G7IA 5FO8C 1QO6A 5HZPB 4CSYA 1H2QP 4YNXA 2RL0A
chains in the Genus database with same CATH superfamily
3WSXA 1TPMA 2W81A 4WJG2 1OJWA 2A55A 2XWBF 3OXUD 4PO7A 2O39C 1OK2A 2I2LA 3T5OA 4B2RA 3NFPI 1G4GA 4JHSA 2ERJA 4C16A 4DJZA 1SRZA 1H04P 3GXEA 5HYUB 2RKZA 1HFHA 3F6KA 1NWVA 1VVDA 1OK9A 1ZJKA 4AYMA 5HYPA 2KMSA 2YBYA 2RLPA 1OK1A 5DN5A 2CKUA 5JPMG 1VVCA 3IX0A 2IZ3A 4F4OC 2LOJA 1E8BA 3VWOA 1H03P 2QY0A 4LOSA 2JGXA 1H2PP 5DN4A 3L89M 4LOTA 1E88A 1CKLA 3K3TA 1SS2A 3O8EB 4J38B 4YIZA 4A5WB 3OP8A 2CG6A 1G4FA 4PZ5A 3KXVA 3ZD1A 5I0QB 1MD8A 3GOVA 4IGDA 4N7EA 1TPNA 1QUBA 1HCCA 3EJHA 3RJ3D 1GKGA 4KKDA 3CALA 1C1ZA 4FXGG 3ERBA 1HFIA 4ZH1D 3ZRZA 4AYIA 3M7PA 1OK3A 4APLA 2KRIA 1LY2A 1O9AA 2RKYA 2Y8RA 3IU3I 3CI0J 3INBC 2X2ZA 1Q3XA 1QGBA 3ZLDA 1PPQA 4BWCA 2XRDA 2CG7A 2WIIC 4MUCA 3NJAA 2JGWA 2V8EA 1OJYA 3MQLA 2MCZA 3FGRA 2XWJI 2MCYA 3R62A 1Z92B 2UWNA 4AYEA 4K12A 2B5ID 3ZD2A 1FBRA 4B2SA 3OEDC 1UOTP 3TVJA 2W80A 4AYDA 2RLQA 3WSYA 1U5MA 2XQWC 2EHFA 1ELVA 3SW0X 2YRAA 4MSLA 5HYTB 2XRBA 1OJVA 3ZLEA 4ONTD 1TPGA 2EC3A 2IZ4A 1GPZA 1GHQB 1RLHA 3FGTA 2ZYCA 1E5GA 2JRAA 1GKNA 3KZJA 1MD7A 2Y8TA 2BZMA 2G7IA 5FO8C 1QO6A 5HZPB 4CSYA 2Y8SA 1H2QP 4YNXA 2RL0A
chains in the Genus database with same CATH topology
1TPMA 2W81A 4WJG2 1OJWA 2A55A 2XWBF 3OXUD 2O39C 1OK2A 4B2RA 3T5OA 3NFPI 1G4GA 4JHSA 2ERJA 4C16A 4DJZA 1SRZA 1H04P 3GXEA 5HYUB 2RKZA 1HFHA 1NWVA 1VVDA 1OK9A 1ZJKA 4AYMA 5HYPA 2KMSA 2YBYA 2RLPA 1OK1A 2CKUA 5JPMG 1VVCA 3IX0A 2IZ3A 4F4OC 2LOJA 1E8BA 1H03P 2QY0A 4LOSA 2JGXA 1H2PP 3L89M 4LOTA 1E88A 1CKLA 1SS2A 3O8EB 4J38B 4A5WB 3OP8A 2CG6A 1G4FA 4PZ5A 3KXVA 3ZD1A 5I0QB 1MD8A 3GOVA 4IGDA 1TPNA 1QUBA 1HCCA 3EJHA 3RJ3D 1GKGA 4KKDA 3CALA 1C1ZA 4FXGG 3ERBA 1HFIA 4ZH1D 3ZRZA 4AYIA 3M7PA 1OK3A 2KRIA 1LY2A 1O9AA 2RKYA 3IU3I 3INBC 1Q3XA 1QGBA 1PPQA 2XRDA 2CG7A 2WIIC 4MUCA 2JGWA 2V8EA 1OJYA 3MQLA 2MCZA 2XWJI 2MCYA 3R62A 1Z92B 2UWNA 4AYEA 4K12A 2B5ID 3ZD2A 1FBRA 4B2SA 3OEDC 1UOTP 3TVJA 2W80A 4AYDA 2RLQA 1U5MA 2XQWC 2EHFA 1ELVA 3SW0X 2YRAA 5HYTB 2XRBA 1OJVA 4ONTD 1TPGA 2EC3A 2IZ4A 1GPZA 1GHQB 1E5GA 2JRAA 1GKNA 3KZJA 1MD7A 2BZMA 2G7IA 5FO8C 1QO6A 5HZPB 4CSYA 1H2QP 4YNXA 2RL0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TPM A;  2W81 A;  4WJG 2;  1OJW A;  2A55 A;  2XWB F;  3OXU D;  2O39 C;  1OK2 A;  4B2R A;  3T5O A;  3NFP I;  1G4G A;  4JHS A;  2ERJ A;  4C16 A;  4DJZ A;  1SRZ A;  1H04 P;  3GXE A;  5HYU B;  2RKZ A;  1HFH A;  1NWV A;  1VVD A;  1OK9 A;  1ZJK A;  4AYM A;  5HYP A;  2KMS A;  2YBY A;  2RLP A;  1OK1 A;  2CKU A;  5JPM G;  1VVC A;  3IX0 A;  2IZ3 A;  4F4O C;  2LOJ A;  1E8B A;  1H03 P;  2QY0 A;  4LOS A;  2JGX A;  1H2P P;  3L89 M;  4LOT A;  1E88 A;  1CKL A;  1SS2 A;  3O8E B;  4J38 B;  4A5W B;  3OP8 A;  2CG6 A;  1G4F A;  4PZ5 A;  3KXV A;  3ZD1 A;  5I0Q B;  1MD8 A;  3GOV A;  4IGD A;  1TPN A;  1QUB A;  1HCC A;  3EJH A;  3RJ3 D;  1GKG A;  4KKD A;  3CAL A;  1C1Z A;  4FXG G;  3ERB A;  1HFI A;  4ZH1 D;  3ZRZ A;  4AYI A;  3M7P A;  1OK3 A;  2KRI A;  1LY2 A;  1O9A A;  2RKY A;  3IU3 I;  3INB C;  1Q3X A;  1QGB A;  1PPQ A;  2XRD A;  2CG7 A;  2WII C;  4MUC A;  2JGW A;  2V8E A;  1OJY A;  3MQL A;  2MCZ A;  2XWJ I;  2MCY A;  3R62 A;  1Z92 B;  2UWN A;  4AYE A;  4K12 A;  2B5I D;  3ZD2 A;  1FBR A;  4B2S A;  3OED C;  1UOT P;  3TVJ A;  2W80 A;  4AYD A;  2RLQ A;  1U5M A;  2XQW C;  2EHF A;  1ELV A;  3SW0 X;  2YRA A;  5HYT B;  2XRB A;  1OJV A;  4ONT D;  1TPG A;  2EC3 A;  2IZ4 A;  1GPZ A;  1GHQ B;  1E5G A;  2JRA A;  1GKN A;  3KZJ A;  1MD7 A;  2BZM A;  2G7I A;  5FO8 C;  1QO6 A;  5HZP B;  4CSY A;  1H2Q P;  4YNX A;  2RL0 A; 
#chains in the Genus database with same CATH topology
 3WSX A;  1TPM A;  2W81 A;  4WJG 2;  1OJW A;  2A55 A;  2XWB F;  3OXU D;  4PO7 A;  2O39 C;  1OK2 A;  2I2L A;  3T5O A;  4B2R A;  3NFP I;  1G4G A;  4JHS A;  2ERJ A;  4C16 A;  4DJZ A;  1SRZ A;  1H04 P;  3GXE A;  5HYU B;  2RKZ A;  1HFH A;  3F6K A;  1NWV A;  1VVD A;  1OK9 A;  1ZJK A;  4AYM A;  5HYP A;  2KMS A;  2YBY A;  2RLP A;  1OK1 A;  5DN5 A;  2CKU A;  5JPM G;  1VVC A;  3IX0 A;  2IZ3 A;  4F4O C;  2LOJ A;  1E8B A;  3VWO A;  1H03 P;  2QY0 A;  4LOS A;  2JGX A;  1H2P P;  5DN4 A;  3L89 M;  4LOT A;  1E88 A;  1CKL A;  3K3T A;  1SS2 A;  3O8E B;  4J38 B;  4YIZ A;  4A5W B;  3OP8 A;  2CG6 A;  1G4F A;  4PZ5 A;  3KXV A;  3ZD1 A;  5I0Q B;  1MD8 A;  3GOV A;  4IGD A;  4N7E A;  1TPN A;  1QUB A;  1HCC A;  3EJH A;  3RJ3 D;  1GKG A;  4KKD A;  3CAL A;  1C1Z A;  4FXG G;  3ERB A;  1HFI A;  4ZH1 D;  3ZRZ A;  4AYI A;  3M7P A;  1OK3 A;  4APL A;  2KRI A;  1LY2 A;  1O9A A;  2RKY A;  2Y8R A;  3IU3 I;  3CI0 J;  3INB C;  2X2Z A;  1Q3X A;  1QGB A;  3ZLD A;  1PPQ A;  4BWC A;  2XRD A;  2CG7 A;  2WII C;  4MUC A;  3NJA A;  2JGW A;  2V8E A;  1OJY A;  3MQL A;  2MCZ A;  3FGR A;  2XWJ I;  2MCY A;  3R62 A;  1Z92 B;  2UWN A;  4AYE A;  4K12 A;  2B5I D;  3ZD2 A;  1FBR A;  4B2S A;  3OED C;  1UOT P;  3TVJ A;  2W80 A;  4AYD A;  2RLQ A;  3WSY A;  1U5M A;  2XQW C;  2EHF A;  1ELV A;  3SW0 X;  2YRA A;  4MSL A;  5HYT B;  2XRB A;  1OJV A;  3ZLE A;  4ONT D;  1TPG A;  2EC3 A;  2IZ4 A;  1GPZ A;  1GHQ B;  1RLH A;  3FGT A;  2ZYC A;  1E5G A;  2JRA A;  1GKN A;  3KZJ A;  1MD7 A;  2Y8T A;  2BZM A;  2G7I A;  5FO8 C;  1QO6 A;  5HZP B;  4CSY A;  2Y8S A;  1H2Q P;  4YNX A;  2RL0 A; 
#chains in the Genus database with same CATH homology
 1TPM A;  2W81 A;  4WJG 2;  1OJW A;  2A55 A;  2XWB F;  3OXU D;  2O39 C;  1OK2 A;  4B2R A;  3T5O A;  3NFP I;  1G4G A;  4JHS A;  2ERJ A;  4C16 A;  4DJZ A;  1SRZ A;  1H04 P;  3GXE A;  5HYU B;  2RKZ A;  1HFH A;  1NWV A;  1VVD A;  1OK9 A;  1ZJK A;  4AYM A;  5HYP A;  2KMS A;  2YBY A;  2RLP A;  1OK1 A;  2CKU A;  5JPM G;  1VVC A;  3IX0 A;  2IZ3 A;  4F4O C;  2LOJ A;  1E8B A;  1H03 P;  2QY0 A;  4LOS A;  2JGX A;  1H2P P;  3L89 M;  4LOT A;  1E88 A;  1CKL A;  1SS2 A;  3O8E B;  4J38 B;  4A5W B;  3OP8 A;  2CG6 A;  1G4F A;  4PZ5 A;  3KXV A;  3ZD1 A;  5I0Q B;  1MD8 A;  3GOV A;  4IGD A;  1TPN A;  1QUB A;  1HCC A;  3EJH A;  3RJ3 D;  1GKG A;  4KKD A;  3CAL A;  1C1Z A;  4FXG G;  3ERB A;  1HFI A;  4ZH1 D;  3ZRZ A;  4AYI A;  3M7P A;  1OK3 A;  2KRI A;  1LY2 A;  1O9A A;  2RKY A;  3IU3 I;  3INB C;  1Q3X A;  1QGB A;  1PPQ A;  2XRD A;  2CG7 A;  2WII C;  4MUC A;  2JGW A;  2V8E A;  1OJY A;  3MQL A;  2MCZ A;  2XWJ I;  2MCY A;  3R62 A;  1Z92 B;  2UWN A;  4AYE A;  4K12 A;  2B5I D;  3ZD2 A;  1FBR A;  4B2S A;  3OED C;  1UOT P;  3TVJ A;  2W80 A;  4AYD A;  2RLQ A;  1U5M A;  2XQW C;  2EHF A;  1ELV A;  3SW0 X;  2YRA A;  5HYT B;  2XRB A;  1OJV A;  4ONT D;  1TPG A;  2EC3 A;  2IZ4 A;  1GPZ A;  1GHQ B;  1E5G A;  2JRA A;  1GKN A;  3KZJ A;  1MD7 A;  2BZM A;  2G7I A;  5FO8 C;  1QO6 A;  5HZP B;  4CSY A;  1H2Q P;  4YNX A;  2RL0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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