2V8EA

Crystal structure of human complement factor h, scr domains 6-8 (h402 risk variant), in complex with ligand.
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
187
structure length
187
Chain Sequence
MGLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune system
molecule keywords COMPLEMENT FACTOR H
publication title Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
pubmed doi rcsb
source organism Homo sapiens
total genus 34
structure length 187
sequence length 187
ec nomenclature
pdb deposition date 2007-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA03
2ERJA 2JGXA 2RL0A 1TPGA 3ERBA 2A55A 3GOVA 2QY0A 5HYTB 1QGBA 1OK2A 1LY2A 4C16A 1NWVA 1H04P 3GXEA 2B5ID 5I0QB 4FXGG 1FBRA 1OK3A 1ELVA 2V8EA 2RKYA 1GHQB 3ZRZA 1TPMA 1ZJKA 1OK1A 2XRBA 1OJWA 2KMSA 1UOTP 4JHSA 4LOTA 3EJHA 3T5OA 1CKLA 2LOJA 3NFPI 2G7IA 2XQWC 4ZH1D 3L89M 2RLQA 2CG7A 4LOSA 1Q3XA 4WJG2 5FO8C 5HZPB 1C1ZA 4AYEA 1OJVA 1H2PP 2BZMA 1H03P 2UWNA 4A5WB 3R62A 3M7PA 1VVCA 5HYUB 1MD8A 1QO6A 4F4OC 4CSYA 4K12A 2W81A 3RJ3D 2YRAA 1E5GA 2KRIA 2XRDA 1E8BA 3ZD1A 3O8EB 3OXUD 1H2QP 2O39C 3TVJA 3ZD2A 4J38B 3IX0A 5JPMG 4B2SA 2JRAA 1GPZA 2JGWA 2WIIC 1O9AA 1SRZA 1SS2A 3OP8A 1G4GA 5HYPA 1G4FA 4IGDA 2MCYA 2EHFA 1HFIA 4ONTD 1GKNA 2YBYA 1TPNA 4B2RA 2IZ4A 3INBC 1PPQA 3KZJA 4AYIA 3MQLA 4KKDA 2EC3A 3CALA 3SW0X 4PZ5A 1GKGA 1Z92B 3IU3I 1MD7A 2RLPA 3OEDC 4AYMA 4AYDA 2CKUA 2MCZA 4YNXA 1OJYA 1HFHA 3KXVA 1U5MA 4DJZA 1E88A 2CG6A 4MUCA 2IZ3A 1HCCA 2W80A 1OK9A 1VVDA 2XWBF 2XWJI 1QUBA 2RKZA
chains in the Genus database with same CATH superfamily
2ERJA 5DN4A 2JGXA 2RL0A 1TPGA 3ERBA 2A55A 3GOVA 2QY0A 5HYTB 1QGBA 1OK2A 1LY2A 4C16A 1NWVA 1H04P 3ZLDA 3GXEA 2ZYCA 2B5ID 5I0QB 4FXGG 1FBRA 1OK3A 1ELVA 4BWCA 2V8EA 4APLA 2RKYA 1GHQB 3ZRZA 1TPMA 1ZJKA 1OK1A 1RLHA 2XRBA 1OJWA 2KMSA 1UOTP 4JHSA 4LOTA 3EJHA 3T5OA 1CKLA 2LOJA 3ZLEA 3NFPI 2G7IA 2XQWC 4ZH1D 3L89M 2RLQA 2CG7A 2Y8TA 4LOSA 1Q3XA 4WJG2 5FO8C 5HZPB 1C1ZA 4AYEA 1OJVA 1H2PP 2BZMA 3WSYA 1H03P 3FGTA 2UWNA 4A5WB 3R62A 3M7PA 4MSLA 1VVCA 5HYUB 3NJAA 1MD8A 1QO6A 4F4OC 5DN5A 4CSYA 4YIZA 4K12A 2W81A 3RJ3D 2YRAA 3CI0J 2KRIA 1E8BA 2XRDA 3ZD1A 1E5GA 3O8EB 3OXUD 4N7EA 1H2QP 2O39C 3TVJA 3ZD2A 4J38B 3IX0A 5JPMG 4B2SA 2X2ZA 2JRAA 1GPZA 2JGWA 2WIIC 1O9AA 1SRZA 1SS2A 3OP8A 1G4GA 5HYPA 1G4FA 4IGDA 2MCYA 2EHFA 1HFIA 4ONTD 1GKNA 2YBYA 1TPNA 4B2RA 2IZ4A 3INBC 1PPQA 3KZJA 4AYIA 3MQLA 4KKDA 2EC3A 2Y8SA 3CALA 3SW0X 4PZ5A 1GKGA 3WSXA 1Z92B 3IU3I 1MD7A 2RLPA 3OEDC 4AYMA 4AYDA 2CKUA 2Y8RA 2MCZA 3F6KA 4YNXA 1OJYA 1HFHA 3KXVA 1U5MA 4DJZA 4PO7A 1E88A 2CG6A 4MUCA 2IZ3A 1HCCA 2W80A 2I2LA 1OK9A 3K3TA 1VVDA 2XWBF 2XWJI 1QUBA 3FGRA 3VWOA 2RKZA
chains in the Genus database with same CATH topology
2ERJA 2JGXA 2RL0A 1TPGA 3ERBA 2A55A 3GOVA 2QY0A 5HYTB 1QGBA 1OK2A 1LY2A 4C16A 1NWVA 1H04P 3GXEA 2B5ID 5I0QB 4FXGG 1FBRA 1OK3A 1ELVA 2V8EA 2RKYA 1GHQB 3ZRZA 1TPMA 1ZJKA 1OK1A 2XRBA 1OJWA 2KMSA 1UOTP 4JHSA 4LOTA 3EJHA 3T5OA 1CKLA 2LOJA 3NFPI 2G7IA 2XQWC 4ZH1D 3L89M 2RLQA 2CG7A 4LOSA 1Q3XA 4WJG2 5FO8C 5HZPB 1C1ZA 4AYEA 1OJVA 1H2PP 2BZMA 1H03P 2UWNA 4A5WB 3R62A 3M7PA 1VVCA 5HYUB 1MD8A 1QO6A 4F4OC 4CSYA 4K12A 2W81A 3RJ3D 2YRAA 1E5GA 2KRIA 2XRDA 1E8BA 3ZD1A 3O8EB 3OXUD 1H2QP 2O39C 3TVJA 3ZD2A 4J38B 3IX0A 5JPMG 4B2SA 2JRAA 1GPZA 2JGWA 2WIIC 1O9AA 1SRZA 1SS2A 3OP8A 1G4GA 5HYPA 1G4FA 4IGDA 2MCYA 2EHFA 1HFIA 4ONTD 1GKNA 2YBYA 1TPNA 4B2RA 2IZ4A 3INBC 1PPQA 3KZJA 4AYIA 3MQLA 4KKDA 2EC3A 3CALA 3SW0X 4PZ5A 1GKGA 1Z92B 3IU3I 1MD7A 2RLPA 3OEDC 4AYMA 4AYDA 2CKUA 2MCZA 4YNXA 1OJYA 1HFHA 3KXVA 1U5MA 4DJZA 1E88A 2CG6A 4MUCA 2IZ3A 1HCCA 2W80A 1OK9A 1VVDA 2XWBF 2XWJI 1QUBA 2RKZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ERJ A;  2JGX A;  2RL0 A;  1TPG A;  3ERB A;  2A55 A;  3GOV A;  2QY0 A;  5HYT B;  1QGB A;  1OK2 A;  1LY2 A;  4C16 A;  1NWV A;  1H04 P;  3GXE A;  2B5I D;  5I0Q B;  4FXG G;  1FBR A;  1OK3 A;  1ELV A;  2V8E A;  2RKY A;  1GHQ B;  3ZRZ A;  1TPM A;  1ZJK A;  1OK1 A;  2XRB A;  1OJW A;  2KMS A;  1UOT P;  4JHS A;  4LOT A;  3EJH A;  3T5O A;  1CKL A;  2LOJ A;  3NFP I;  2G7I A;  2XQW C;  4ZH1 D;  3L89 M;  2RLQ A;  2CG7 A;  4LOS A;  1Q3X A;  4WJG 2;  5FO8 C;  5HZP B;  1C1Z A;  4AYE A;  1OJV A;  1H2P P;  2BZM A;  1H03 P;  2UWN A;  4A5W B;  3R62 A;  3M7P A;  1VVC A;  5HYU B;  1MD8 A;  1QO6 A;  4F4O C;  4CSY A;  4K12 A;  2W81 A;  3RJ3 D;  2YRA A;  1E5G A;  2KRI A;  2XRD A;  1E8B A;  3ZD1 A;  3O8E B;  3OXU D;  1H2Q P;  2O39 C;  3TVJ A;  3ZD2 A;  4J38 B;  3IX0 A;  5JPM G;  4B2S A;  2JRA A;  1GPZ A;  2JGW A;  2WII C;  1O9A A;  1SRZ A;  1SS2 A;  3OP8 A;  1G4G A;  5HYP A;  1G4F A;  4IGD A;  2MCY A;  2EHF A;  1HFI A;  4ONT D;  1GKN A;  2YBY A;  1TPN A;  4B2R A;  2IZ4 A;  3INB C;  1PPQ A;  3KZJ A;  4AYI A;  3MQL A;  4KKD A;  2EC3 A;  3CAL A;  3SW0 X;  4PZ5 A;  1GKG A;  1Z92 B;  3IU3 I;  1MD7 A;  2RLP A;  3OED C;  4AYM A;  4AYD A;  2CKU A;  2MCZ A;  4YNX A;  1OJY A;  1HFH A;  3KXV A;  1U5M A;  4DJZ A;  1E88 A;  2CG6 A;  4MUC A;  2IZ3 A;  1HCC A;  2W80 A;  1OK9 A;  1VVD A;  2XWB F;  2XWJ I;  1QUB A;  2RKZ A; 
#chains in the Genus database with same CATH topology
 2ERJ A;  5DN4 A;  2JGX A;  2RL0 A;  1TPG A;  3ERB A;  2A55 A;  3GOV A;  2QY0 A;  5HYT B;  1QGB A;  1OK2 A;  1LY2 A;  4C16 A;  1NWV A;  1H04 P;  3ZLD A;  3GXE A;  2ZYC A;  2B5I D;  5I0Q B;  4FXG G;  1FBR A;  1OK3 A;  1ELV A;  4BWC A;  2V8E A;  4APL A;  2RKY A;  1GHQ B;  3ZRZ A;  1TPM A;  1ZJK A;  1OK1 A;  1RLH A;  2XRB A;  1OJW A;  2KMS A;  1UOT P;  4JHS A;  4LOT A;  3EJH A;  3T5O A;  1CKL A;  2LOJ A;  3ZLE A;  3NFP I;  2G7I A;  2XQW C;  4ZH1 D;  3L89 M;  2RLQ A;  2CG7 A;  2Y8T A;  4LOS A;  1Q3X A;  4WJG 2;  5FO8 C;  5HZP B;  1C1Z A;  4AYE A;  1OJV A;  1H2P P;  2BZM A;  3WSY A;  1H03 P;  3FGT A;  2UWN A;  4A5W B;  3R62 A;  3M7P A;  4MSL A;  1VVC A;  5HYU B;  3NJA A;  1MD8 A;  1QO6 A;  4F4O C;  5DN5 A;  4CSY A;  4YIZ A;  4K12 A;  2W81 A;  3RJ3 D;  2YRA A;  3CI0 J;  2KRI A;  1E8B A;  2XRD A;  3ZD1 A;  1E5G A;  3O8E B;  3OXU D;  4N7E A;  1H2Q P;  2O39 C;  3TVJ A;  3ZD2 A;  4J38 B;  3IX0 A;  5JPM G;  4B2S A;  2X2Z A;  2JRA A;  1GPZ A;  2JGW A;  2WII C;  1O9A A;  1SRZ A;  1SS2 A;  3OP8 A;  1G4G A;  5HYP A;  1G4F A;  4IGD A;  2MCY A;  2EHF A;  1HFI A;  4ONT D;  1GKN A;  2YBY A;  1TPN A;  4B2R A;  2IZ4 A;  3INB C;  1PPQ A;  3KZJ A;  4AYI A;  3MQL A;  4KKD A;  2EC3 A;  2Y8S A;  3CAL A;  3SW0 X;  4PZ5 A;  1GKG A;  3WSX A;  1Z92 B;  3IU3 I;  1MD7 A;  2RLP A;  3OED C;  4AYM A;  4AYD A;  2CKU A;  2Y8R A;  2MCZ A;  3F6K A;  4YNX A;  1OJY A;  1HFH A;  3KXV A;  1U5M A;  4DJZ A;  4PO7 A;  1E88 A;  2CG6 A;  4MUC A;  2IZ3 A;  1HCC A;  2W80 A;  2I2L A;  1OK9 A;  3K3T A;  1VVD A;  2XWB F;  2XWJ I;  1QUB A;  3FGR A;  3VWO A;  2RKZ A; 
#chains in the Genus database with same CATH homology
 2ERJ A;  2JGX A;  2RL0 A;  1TPG A;  3ERB A;  2A55 A;  3GOV A;  2QY0 A;  5HYT B;  1QGB A;  1OK2 A;  1LY2 A;  4C16 A;  1NWV A;  1H04 P;  3GXE A;  2B5I D;  5I0Q B;  4FXG G;  1FBR A;  1OK3 A;  1ELV A;  2V8E A;  2RKY A;  1GHQ B;  3ZRZ A;  1TPM A;  1ZJK A;  1OK1 A;  2XRB A;  1OJW A;  2KMS A;  1UOT P;  4JHS A;  4LOT A;  3EJH A;  3T5O A;  1CKL A;  2LOJ A;  3NFP I;  2G7I A;  2XQW C;  4ZH1 D;  3L89 M;  2RLQ A;  2CG7 A;  4LOS A;  1Q3X A;  4WJG 2;  5FO8 C;  5HZP B;  1C1Z A;  4AYE A;  1OJV A;  1H2P P;  2BZM A;  1H03 P;  2UWN A;  4A5W B;  3R62 A;  3M7P A;  1VVC A;  5HYU B;  1MD8 A;  1QO6 A;  4F4O C;  4CSY A;  4K12 A;  2W81 A;  3RJ3 D;  2YRA A;  1E5G A;  2KRI A;  2XRD A;  1E8B A;  3ZD1 A;  3O8E B;  3OXU D;  1H2Q P;  2O39 C;  3TVJ A;  3ZD2 A;  4J38 B;  3IX0 A;  5JPM G;  4B2S A;  2JRA A;  1GPZ A;  2JGW A;  2WII C;  1O9A A;  1SRZ A;  1SS2 A;  3OP8 A;  1G4G A;  5HYP A;  1G4F A;  4IGD A;  2MCY A;  2EHF A;  1HFI A;  4ONT D;  1GKN A;  2YBY A;  1TPN A;  4B2R A;  2IZ4 A;  3INB C;  1PPQ A;  3KZJ A;  4AYI A;  3MQL A;  4KKD A;  2EC3 A;  3CAL A;  3SW0 X;  4PZ5 A;  1GKG A;  1Z92 B;  3IU3 I;  1MD7 A;  2RLP A;  3OED C;  4AYM A;  4AYD A;  2CKU A;  2MCZ A;  4YNX A;  1OJY A;  1HFH A;  3KXV A;  1U5M A;  4DJZ A;  1E88 A;  2CG6 A;  4MUC A;  2IZ3 A;  1HCC A;  2W80 A;  1OK9 A;  1VVD A;  2XWB F;  2XWJ I;  1QUB A;  2RKZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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