2J91A

Crystal structure of human adenylosuccinate lyase in complex with amp
Total Genus 182
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
182
sequence length
470
structure length
457
Chain Sequence
GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIREMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYES
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Human Adenylosuccinate Lyase
rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords ADENYLOSUCCINATE LYASE
total genus 182
structure length 457
sequence length 470
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2006-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2j91A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2j91A02
3GZHA 5F91A 2O6YA 1GK2A 3OCFA 1K62A 1I0AA 1C3UA 2RJRA 2O7DA 1TJUA 1VDKA 1HY0A 1TJ7A 4APAA 2PTQA 1DOFA 5HW2A 1GKJA 2PFMA 3RRPA 4C5SA 2J91A 1FUPA 4EFCA 1FURA 1GKMA 2RJSA 4BAAA 5D6BA 1B8FA 4C5RA 4HGVA 2VD6A 1HY1A 5EYVA 3KDZA 2FUSA 3QBPA 4EEIA 1U15A 1FUQA 3BHGA 2NYFA 2O7EA 2X75A 4ADLA 1U16A 1FUOA 2PTRA 4FLCA 3R6QA 2OHYA 3CZOA 1JSWA 1YFEA 3KDYA 4C6GA 1TJWA 1Q5NA 5EYTA 3NZ4A 3GTDA 3NO9A 1AUWA 1C3CA 4APBA 4MX2A 3UNVA 5F92A 1GK3A 4CQ5A 2E9FA 1EB4A 2QGAB 4ADMA 1DCNA 2PTSA 4NLEA 1T6JA 4NSLA 3R6VA 2QVEA 1K7WA 3C8TA 2HVGA 2YIIA 4BABA 3E04A 1XWOA 4C5UA 1W27A 1YISA 1T6PA 1YFMA 2NYNA 1RE5A 3R6YA 2O7BA 2O7FA 4V2QA 1J3UA 4FFXA 3TV2A 1TJVA 1KQ7A 3OCEA 2O78A 1Y2MA 4V2RA 3RD8A
chains in the Genus database with same CATH superfamily
3GZHA 5F91A 2O6YA 1GK2A 3OCFA 1K62A 1I0AA 1C3UA 2RJRA 2O7DA 3CRVA 1TJUA 5M0IA 1VDKA 1HY0A 1TJ7A 4APAA 2FENA 1XMCA 2PTQA 1DOFA 5HW2A 1GKJA 2PFMA 3RRPA 4C5SA 2J91A 1FUPA 4EFCA 1FURA 1GKMA 2RJSA 4BAAA 5D6BA 1B8FA 4C5RA 4HGVA 2VD6A 1HY1A 1XL7A 5EYVA 3KDZA 2FUSA 3QBPA 4EEIA 1U15A 1FUQA 3BHGA 2NYFA 2O7EA 2X75A 4ADLA 1U16A 1FUOA 2PTRA 4FLCA 3R6QA 2OHYA 3CZOA 5M0JA 1JSWA 1YFEA 3KDYA 4C6GA 1TJWA 1Q5NA 5EYTA 3NZ4A 3GTDA 3NO9A 1AUWA 1C3CA 4APBA 4MX2A 3UNVA 5F92A 1XMDA 2VL7A 1GK3A 4WNLA 4CQ5A 2E9FA 2VSFA 1EB4A 2QGAB 1KQ7A 4A15A 4ADMA 1DCNA 2PTSA 4NLEA 1T6JA 4NSLA 3R6VA 2QVEA 1XLYA 1K7WA 3C8TA 2HVGA 2YIIA 4BABA 3E04A 1XWOA 5H8WA 4C5UA 1XL8A 1W27A 1YISA 1T6PA 1YFMA 2NYNA 2FELA 1RE5A 3R6YA 2O7BA 2O7FA 4V2QA 1J3UA 4FFXA 3TV2A 1TJVA 3CRW1 3OCEA 2O78A 1Y2MA 4V2RA 3RD8A
chains in the Genus database with same CATH topology
3GZHA 5F91A 2O6YA 1GK2A 3OCFA 1K62A 1I0AA 1C3UA 2RJRA 2O7DA 1TJUA 1VDKA 1HY0A 1TJ7A 4APAA 2PTQA 1DOFA 5HW2A 1GKJA 2PFMA 3RRPA 4C5SA 2J91A 1FUPA 4EFCA 1FURA 1GKMA 2RJSA 4BAAA 5D6BA 1B8FA 4C5RA 4HGVA 2VD6A 1HY1A 5EYVA 3KDZA 2FUSA 3QBPA 4EEIA 1U15A 1FUQA 3BHGA 2NYFA 2O7EA 2X75A 4ADLA 1U16A 1FUOA 2PTRA 4FLCA 3R6QA 2OHYA 3CZOA 1JSWA 1YFEA 3KDYA 4C6GA 1TJWA 1Q5NA 5EYTA 3NZ4A 3GTDA 3NO9A 1AUWA 1C3CA 4APBA 4MX2A 3UNVA 5F92A 1GK3A 4CQ5A 2E9FA 1EB4A 2QGAB 4ADMA 1DCNA 2PTSA 4NLEA 1T6JA 4NSLA 3R6VA 2QVEA 1K7WA 3C8TA 2HVGA 2YIIA 4BABA 3E04A 1XWOA 4C5UA 1W27A 1YISA 1T6PA 1YFMA 2NYNA 1RE5A 3R6YA 2O7BA 2O7FA 4V2QA 1J3UA 4FFXA 3TV2A 1TJVA 1KQ7A 3OCEA 2O78A 1Y2MA 4V2RA 3RD8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GZH A;  5F91 A;  2O6Y A;  1GK2 A;  3OCF A;  1K62 A;  1I0A A;  1C3U A;  2RJR A;  2O7D A;  1TJU A;  1VDK A;  1HY0 A;  1TJ7 A;  4APA A;  2PTQ A;  1DOF A;  5HW2 A;  1GKJ A;  2PFM A;  3RRP A;  4C5S A;  2J91 A;  1FUP A;  4EFC A;  1FUR A;  1GKM A;  2RJS A;  4BAA A;  5D6B A;  1B8F A;  4C5R A;  4HGV A;  2VD6 A;  1HY1 A;  5EYV A;  3KDZ A;  2FUS A;  3QBP A;  4EEI A;  1U15 A;  1FUQ A;  3BHG A;  2NYF A;  2O7E A;  2X75 A;  4ADL A;  1U16 A;  1FUO A;  2PTR A;  4FLC A;  3R6Q A;  2OHY A;  3CZO A;  1JSW A;  1YFE A;  3KDY A;  4C6G A;  1TJW A;  1Q5N A;  5EYT A;  3NZ4 A;  3GTD A;  3NO9 A;  1AUW A;  1C3C A;  4APB A;  4MX2 A;  3UNV A;  5F92 A;  1GK3 A;  4CQ5 A;  2E9F A;  1EB4 A;  2QGA B;  4ADM A;  1DCN A;  2PTS A;  4NLE A;  1T6J A;  4NSL A;  3R6V A;  2QVE A;  1K7W A;  3C8T A;  2HVG A;  2YII A;  4BAB A;  3E04 A;  1XWO A;  4C5U A;  1W27 A;  1YIS A;  1T6P A;  1YFM A;  2NYN A;  1RE5 A;  3R6Y A;  2O7B A;  2O7F A;  4V2Q A;  1J3U A;  4FFX A;  3TV2 A;  1TJV A;  1KQ7 A;  3OCE A;  2O78 A;  1Y2M A;  4V2R A;  3RD8 A; 
#chains in the Genus database with same CATH topology
 3GZH A;  5F91 A;  2O6Y A;  1GK2 A;  3OCF A;  1K62 A;  1I0A A;  1C3U A;  2RJR A;  2O7D A;  3CRV A;  1TJU A;  5M0I A;  1VDK A;  1HY0 A;  1TJ7 A;  4APA A;  2FEN A;  1XMC A;  2PTQ A;  1DOF A;  5HW2 A;  1GKJ A;  2PFM A;  3RRP A;  4C5S A;  2J91 A;  1FUP A;  4EFC A;  1FUR A;  1GKM A;  2RJS A;  4BAA A;  5D6B A;  1B8F A;  4C5R A;  4HGV A;  2VD6 A;  1HY1 A;  1XL7 A;  5EYV A;  3KDZ A;  2FUS A;  3QBP A;  4EEI A;  1U15 A;  1FUQ A;  3BHG A;  2NYF A;  2O7E A;  2X75 A;  4ADL A;  1U16 A;  1FUO A;  2PTR A;  4FLC A;  3R6Q A;  2OHY A;  3CZO A;  5M0J A;  1JSW A;  1YFE A;  3KDY A;  4C6G A;  1TJW A;  1Q5N A;  5EYT A;  3NZ4 A;  3GTD A;  3NO9 A;  1AUW A;  1C3C A;  4APB A;  4MX2 A;  3UNV A;  5F92 A;  1XMD A;  2VL7 A;  1GK3 A;  4WNL A;  4CQ5 A;  2E9F A;  2VSF A;  1EB4 A;  2QGA B;  1KQ7 A;  4A15 A;  4ADM A;  1DCN A;  2PTS A;  4NLE A;  1T6J A;  4NSL A;  3R6V A;  2QVE A;  1XLY A;  1K7W A;  3C8T A;  2HVG A;  2YII A;  4BAB A;  3E04 A;  1XWO A;  5H8W A;  4C5U A;  1XL8 A;  1W27 A;  1YIS A;  1T6P A;  1YFM A;  2NYN A;  2FEL A;  1RE5 A;  3R6Y A;  2O7B A;  2O7F A;  4V2Q A;  1J3U A;  4FFX A;  3TV2 A;  1TJV A;  3CRW 1;  3OCE A;  2O78 A;  1Y2M A;  4V2R A;  3RD8 A; 
#chains in the Genus database with same CATH homology
 3GZH A;  5F91 A;  2O6Y A;  1GK2 A;  3OCF A;  1K62 A;  1I0A A;  1C3U A;  2RJR A;  2O7D A;  1TJU A;  1VDK A;  1HY0 A;  1TJ7 A;  4APA A;  2PTQ A;  1DOF A;  5HW2 A;  1GKJ A;  2PFM A;  3RRP A;  4C5S A;  2J91 A;  1FUP A;  4EFC A;  1FUR A;  1GKM A;  2RJS A;  4BAA A;  5D6B A;  1B8F A;  4C5R A;  4HGV A;  2VD6 A;  1HY1 A;  5EYV A;  3KDZ A;  2FUS A;  3QBP A;  4EEI A;  1U15 A;  1FUQ A;  3BHG A;  2NYF A;  2O7E A;  2X75 A;  4ADL A;  1U16 A;  1FUO A;  2PTR A;  4FLC A;  3R6Q A;  2OHY A;  3CZO A;  1JSW A;  1YFE A;  3KDY A;  4C6G A;  1TJW A;  1Q5N A;  5EYT A;  3NZ4 A;  3GTD A;  3NO9 A;  1AUW A;  1C3C A;  4APB A;  4MX2 A;  3UNV A;  5F92 A;  1GK3 A;  4CQ5 A;  2E9F A;  1EB4 A;  2QGA B;  4ADM A;  1DCN A;  2PTS A;  4NLE A;  1T6J A;  4NSL A;  3R6V A;  2QVE A;  1K7W A;  3C8T A;  2HVG A;  2YII A;  4BAB A;  3E04 A;  1XWO A;  4C5U A;  1W27 A;  1YIS A;  1T6P A;  1YFM A;  2NYN A;  1RE5 A;  3R6Y A;  2O7B A;  2O7F A;  4V2Q A;  1J3U A;  4FFX A;  3TV2 A;  1TJV A;  1KQ7 A;  3OCE A;  2O78 A;  1Y2M A;  4V2R A;  3RD8 A; 
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