2JGWA

Structure of ccp module 7 of complement factor h - the amd at risk varient (402h)
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
61
structure length
61
Chain Sequence
LRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune response
source organism Homo sapiens
publication title Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
pubmed doi rcsb
molecule keywords COMPLEMENT FACTOR H
total genus 11
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2007-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2jgwA00
2XWJI 3IX0A 2A55A 3M7PA 5HYTB 1C1ZA 4AYDA 2QY0A 2EHFA 4LOTA 1E88A 3ZD1A 1LY2A 2B5ID 2W81A 4PZ5A 4JHSA 4C16A 3CALA 3RJ3D 3T5OA 2RLQA 2XRBA 2CG6A 2IZ3A 1ELVA 4F4OC 1H2QP 3INBC 1UOTP 4AYIA 4IGDA 3ZRZA 1SS2A 1PPQA 2LOJA 2XWBF 3R62A 3OP8A 4B2RA 1OJYA 3MQLA 5I0QB 2XRDA 2KRIA 4K12A 1OK3A 1QGBA 3L89M 5HYUB 2W80A 1U5MA 4A5WB 1HFHA 2JRAA 1VVCA 1OK1A 1ZJKA 2ERJA 2YBYA 5HZPB 3GXEA 3ERBA 2IZ4A 4YNXA 2EC3A 4ONTD 5HYPA 5FO8C 3KZJA 2KMSA 1E5GA 4WJG2 4ZH1D 4DJZA 2YRAA 1H04P 3GOVA 2V8EA 5JPMG 1GHQB 1SRZA 4MUCA 1GKGA 1VVDA 1GPZA 2RLPA 2WIIC 3IU3I 1Q3XA 1QUBA 2CG7A 4J38B 4AYMA 4B2SA 4CSYA 2RL0A 4FXGG 1H2PP 3TVJA 3ZD2A 2JGWA 2MCYA 2CKUA 2XQWC 1O9AA 1E8BA 2O39C 1CKLA 1MD7A 1G4GA 2RKZA 3O8EB 1Z92B 2G7IA 1HCCA 3EJHA 1HFIA 3NFPI 1GKNA 1H03P 1NWVA 2UWNA 1OJVA 1TPMA 1G4FA 1MD8A 2RKYA 4LOSA 3OXUD 4KKDA 1OK9A 3KXVA 4AYEA 3SW0X 2JGXA 3OEDC 1FBRA 1QO6A 1OJWA 2BZMA 1TPGA 2MCZA 1OK2A 1TPNA
chains in the Genus database with same CATH superfamily
2XWJI 3IX0A 2A55A 3M7PA 5HYTB 1C1ZA 4AYDA 2QY0A 2EHFA 4LOTA 1E88A 3ZD1A 1LY2A 2B5ID 2W81A 4PZ5A 4JHSA 3K3TA 2I2LA 4BWCA 4C16A 3CALA 3RJ3D 2Y8TA 3T5OA 2RLQA 2XRBA 2CG6A 2IZ3A 1ELVA 4PO7A 3ZLDA 1H2QP 3INBC 1UOTP 3CI0J 4IGDA 3ZRZA 2Y8SA 4AYIA 1SS2A 1PPQA 2LOJA 3ZLEA 2XWBF 3R62A 3OP8A 4B2RA 1OJYA 3MQLA 5I0QB 2XRDA 2KRIA 4K12A 1OK3A 1QGBA 3L89M 5HYUB 2W80A 1U5MA 4A5WB 1HFHA 2JRAA 1VVCA 1OK1A 1ZJKA 2ERJA 2YBYA 5HZPB 3GXEA 3ERBA 3FGTA 2IZ4A 4YNXA 2EC3A 4ONTD 5HYPA 5FO8C 3VWOA 2ZYCA 3KZJA 2KMSA 1E5GA 4WJG2 4ZH1D 5DN4A 4DJZA 2YRAA 1H04P 3GOVA 2V8EA 5JPMG 4YIZA 1GHQB 4F4OC 1SRZA 4MUCA 1GKGA 1VVDA 1GPZA 2RLPA 3WSXA 4APLA 2WIIC 3IU3I 1Q3XA 1QUBA 2CG7A 4J38B 4AYMA 4B2SA 4CSYA 2RL0A 4FXGG 1H2PP 2Y8RA 3TVJA 3ZD2A 2JGWA 2MCYA 2CKUA 2XQWC 1O9AA 1E8BA 2O39C 3F6KA 1CKLA 1MD7A 1G4GA 2RKZA 3O8EB 1Z92B 2G7IA 1HCCA 3EJHA 1HFIA 3NFPI 1GKNA 1H03P 1NWVA 2UWNA 1OJVA 1TPMA 3WSYA 1G4FA 2X2ZA 1MD8A 2RKYA 3FGRA 3NJAA 1RLHA 4MSLA 4LOSA 3OXUD 4KKDA 1OK9A 3KXVA 4N7EA 4AYEA 3SW0X 2JGXA 3OEDC 1FBRA 1QO6A 1OJWA 2BZMA 1TPGA 2MCZA 1OK2A 1TPNA 5DN5A
chains in the Genus database with same CATH topology
2XWJI 3IX0A 2A55A 3M7PA 5HYTB 1C1ZA 4AYDA 2QY0A 2EHFA 4LOTA 1E88A 3ZD1A 1LY2A 2B5ID 2W81A 4PZ5A 4JHSA 4C16A 3CALA 3RJ3D 3T5OA 2RLQA 2XRBA 2CG6A 2IZ3A 1ELVA 4F4OC 1H2QP 3INBC 1UOTP 4AYIA 4IGDA 3ZRZA 1SS2A 1PPQA 2LOJA 2XWBF 3R62A 3OP8A 4B2RA 1OJYA 3MQLA 5I0QB 2XRDA 2KRIA 4K12A 1OK3A 1QGBA 3L89M 5HYUB 2W80A 1U5MA 4A5WB 1HFHA 2JRAA 1VVCA 1OK1A 1ZJKA 2ERJA 2YBYA 5HZPB 3GXEA 3ERBA 2IZ4A 4YNXA 2EC3A 4ONTD 5HYPA 5FO8C 3KZJA 2KMSA 1E5GA 4WJG2 4ZH1D 4DJZA 2YRAA 1H04P 3GOVA 2V8EA 5JPMG 1GHQB 1SRZA 4MUCA 1GKGA 1VVDA 1GPZA 2RLPA 2WIIC 3IU3I 1Q3XA 1QUBA 2CG7A 4J38B 4AYMA 4B2SA 4CSYA 2RL0A 4FXGG 1H2PP 3TVJA 3ZD2A 2JGWA 2MCYA 2CKUA 2XQWC 1O9AA 1E8BA 2O39C 1CKLA 1MD7A 1G4GA 2RKZA 3O8EB 1Z92B 2G7IA 1HCCA 3EJHA 1HFIA 3NFPI 1GKNA 1H03P 1NWVA 2UWNA 1OJVA 1TPMA 1G4FA 1MD8A 2RKYA 4LOSA 3OXUD 4KKDA 1OK9A 3KXVA 4AYEA 3SW0X 2JGXA 3OEDC 1FBRA 1QO6A 1OJWA 2BZMA 1TPGA 2MCZA 1OK2A 1TPNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XWJ I;  3IX0 A;  2A55 A;  3M7P A;  5HYT B;  1C1Z A;  4AYD A;  2QY0 A;  2EHF A;  4LOT A;  1E88 A;  3ZD1 A;  1LY2 A;  2B5I D;  2W81 A;  4PZ5 A;  4JHS A;  4C16 A;  3CAL A;  3RJ3 D;  3T5O A;  2RLQ A;  2XRB A;  2CG6 A;  2IZ3 A;  1ELV A;  4F4O C;  1H2Q P;  3INB C;  1UOT P;  4AYI A;  4IGD A;  3ZRZ A;  1SS2 A;  1PPQ A;  2LOJ A;  2XWB F;  3R62 A;  3OP8 A;  4B2R A;  1OJY A;  3MQL A;  5I0Q B;  2XRD A;  2KRI A;  4K12 A;  1OK3 A;  1QGB A;  3L89 M;  5HYU B;  2W80 A;  1U5M A;  4A5W B;  1HFH A;  2JRA A;  1VVC A;  1OK1 A;  1ZJK A;  2ERJ A;  2YBY A;  5HZP B;  3GXE A;  3ERB A;  2IZ4 A;  4YNX A;  2EC3 A;  4ONT D;  5HYP A;  5FO8 C;  3KZJ A;  2KMS A;  1E5G A;  4WJG 2;  4ZH1 D;  4DJZ A;  2YRA A;  1H04 P;  3GOV A;  2V8E A;  5JPM G;  1GHQ B;  1SRZ A;  4MUC A;  1GKG A;  1VVD A;  1GPZ A;  2RLP A;  2WII C;  3IU3 I;  1Q3X A;  1QUB A;  2CG7 A;  4J38 B;  4AYM A;  4B2S A;  4CSY A;  2RL0 A;  4FXG G;  1H2P P;  3TVJ A;  3ZD2 A;  2JGW A;  2MCY A;  2CKU A;  2XQW C;  1O9A A;  1E8B A;  2O39 C;  1CKL A;  1MD7 A;  1G4G A;  2RKZ A;  3O8E B;  1Z92 B;  2G7I A;  1HCC A;  3EJH A;  1HFI A;  3NFP I;  1GKN A;  1H03 P;  1NWV A;  2UWN A;  1OJV A;  1TPM A;  1G4F A;  1MD8 A;  2RKY A;  4LOS A;  3OXU D;  4KKD A;  1OK9 A;  3KXV A;  4AYE A;  3SW0 X;  2JGX A;  3OED C;  1FBR A;  1QO6 A;  1OJW A;  2BZM A;  1TPG A;  2MCZ A;  1OK2 A;  1TPN A; 
#chains in the Genus database with same CATH topology
 2XWJ I;  3IX0 A;  2A55 A;  3M7P A;  5HYT B;  1C1Z A;  4AYD A;  2QY0 A;  2EHF A;  4LOT A;  1E88 A;  3ZD1 A;  1LY2 A;  2B5I D;  2W81 A;  4PZ5 A;  4JHS A;  3K3T A;  2I2L A;  4BWC A;  4C16 A;  3CAL A;  3RJ3 D;  2Y8T A;  3T5O A;  2RLQ A;  2XRB A;  2CG6 A;  2IZ3 A;  1ELV A;  4PO7 A;  3ZLD A;  1H2Q P;  3INB C;  1UOT P;  3CI0 J;  4IGD A;  3ZRZ A;  2Y8S A;  4AYI A;  1SS2 A;  1PPQ A;  2LOJ A;  3ZLE A;  2XWB F;  3R62 A;  3OP8 A;  4B2R A;  1OJY A;  3MQL A;  5I0Q B;  2XRD A;  2KRI A;  4K12 A;  1OK3 A;  1QGB A;  3L89 M;  5HYU B;  2W80 A;  1U5M A;  4A5W B;  1HFH A;  2JRA A;  1VVC A;  1OK1 A;  1ZJK A;  2ERJ A;  2YBY A;  5HZP B;  3GXE A;  3ERB A;  3FGT A;  2IZ4 A;  4YNX A;  2EC3 A;  4ONT D;  5HYP A;  5FO8 C;  3VWO A;  2ZYC A;  3KZJ A;  2KMS A;  1E5G A;  4WJG 2;  4ZH1 D;  5DN4 A;  4DJZ A;  2YRA A;  1H04 P;  3GOV A;  2V8E A;  5JPM G;  4YIZ A;  1GHQ B;  4F4O C;  1SRZ A;  4MUC A;  1GKG A;  1VVD A;  1GPZ A;  2RLP A;  3WSX A;  4APL A;  2WII C;  3IU3 I;  1Q3X A;  1QUB A;  2CG7 A;  4J38 B;  4AYM A;  4B2S A;  4CSY A;  2RL0 A;  4FXG G;  1H2P P;  2Y8R A;  3TVJ A;  3ZD2 A;  2JGW A;  2MCY A;  2CKU A;  2XQW C;  1O9A A;  1E8B A;  2O39 C;  3F6K A;  1CKL A;  1MD7 A;  1G4G A;  2RKZ A;  3O8E B;  1Z92 B;  2G7I A;  1HCC A;  3EJH A;  1HFI A;  3NFP I;  1GKN A;  1H03 P;  1NWV A;  2UWN A;  1OJV A;  1TPM A;  3WSY A;  1G4F A;  2X2Z A;  1MD8 A;  2RKY A;  3FGR A;  3NJA A;  1RLH A;  4MSL A;  4LOS A;  3OXU D;  4KKD A;  1OK9 A;  3KXV A;  4N7E A;  4AYE A;  3SW0 X;  2JGX A;  3OED C;  1FBR A;  1QO6 A;  1OJW A;  2BZM A;  1TPG A;  2MCZ A;  1OK2 A;  1TPN A;  5DN5 A; 
#chains in the Genus database with same CATH homology
 2XWJ I;  3IX0 A;  2A55 A;  3M7P A;  5HYT B;  1C1Z A;  4AYD A;  2QY0 A;  2EHF A;  4LOT A;  1E88 A;  3ZD1 A;  1LY2 A;  2B5I D;  2W81 A;  4PZ5 A;  4JHS A;  4C16 A;  3CAL A;  3RJ3 D;  3T5O A;  2RLQ A;  2XRB A;  2CG6 A;  2IZ3 A;  1ELV A;  4F4O C;  1H2Q P;  3INB C;  1UOT P;  4AYI A;  4IGD A;  3ZRZ A;  1SS2 A;  1PPQ A;  2LOJ A;  2XWB F;  3R62 A;  3OP8 A;  4B2R A;  1OJY A;  3MQL A;  5I0Q B;  2XRD A;  2KRI A;  4K12 A;  1OK3 A;  1QGB A;  3L89 M;  5HYU B;  2W80 A;  1U5M A;  4A5W B;  1HFH A;  2JRA A;  1VVC A;  1OK1 A;  1ZJK A;  2ERJ A;  2YBY A;  5HZP B;  3GXE A;  3ERB A;  2IZ4 A;  4YNX A;  2EC3 A;  4ONT D;  5HYP A;  5FO8 C;  3KZJ A;  2KMS A;  1E5G A;  4WJG 2;  4ZH1 D;  4DJZ A;  2YRA A;  1H04 P;  3GOV A;  2V8E A;  5JPM G;  1GHQ B;  1SRZ A;  4MUC A;  1GKG A;  1VVD A;  1GPZ A;  2RLP A;  2WII C;  3IU3 I;  1Q3X A;  1QUB A;  2CG7 A;  4J38 B;  4AYM A;  4B2S A;  4CSY A;  2RL0 A;  4FXG G;  1H2P P;  3TVJ A;  3ZD2 A;  2JGW A;  2MCY A;  2CKU A;  2XQW C;  1O9A A;  1E8B A;  2O39 C;  1CKL A;  1MD7 A;  1G4G A;  2RKZ A;  3O8E B;  1Z92 B;  2G7I A;  1HCC A;  3EJH A;  1HFI A;  3NFP I;  1GKN A;  1H03 P;  1NWV A;  2UWN A;  1OJV A;  1TPM A;  1G4F A;  1MD8 A;  2RKY A;  4LOS A;  3OXU D;  4KKD A;  1OK9 A;  3KXV A;  4AYE A;  3SW0 X;  2JGX A;  3OED C;  1FBR A;  1QO6 A;  1OJW A;  2BZM A;  1TPG A;  2MCZ A;  1OK2 A;  1TPN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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