2JGWA

Structure of ccp module 7 of complement factor h - the amd at risk varient (402h)
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
61
structure length
61
Chain Sequence
LRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
pubmed doi rcsb
molecule tags Immune response
source organism Homo sapiens
molecule keywords COMPLEMENT FACTOR H
total genus 11
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2007-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2jgwA00
5I0QB 3GOVA 3ERBA 3KXVA 4LOSA 3EJHA 1E88A 2QY0A 2RKZA 3R62A 5HYPA 1OK2A 1MD7A 4KKDA 1PPQA 1OK3A 2MCZA 3SW0X 2IZ4A 1GKGA 3ZD1A 1FBRA 3CALA 1VVDA 1ELVA 1E5GA 4ONTD 2XWJI 1H03P 4B2SA 1U5MA 1G4GA 2XWBF 4LOTA 1O9AA 1QO6A 1H04P 1OJVA 1Q3XA 1HFHA 1ZJKA 4FXGG 5HYTB 3O8EB 1QGBA 2CG7A 4JHSA 1CKLA 2XRBA 1HFIA 1E8BA 4CSYA 3L89M 3M7PA 4DJZA 4J38B 3ZRZA 2A55A 3OXUD 1OJYA 1H2PP 2XQWC 2EHFA 2IZ3A 3OP8A 4AYEA 1OK1A 1TPMA 5FO8C 1G4FA 2JRAA 2LOJA 5HYUB 5JPMG 4WJG2 4ZH1D 2RLPA 1UOTP 4IGDA 2KMSA 2RLQA 2RKYA 2O39C 1MD8A 1SS2A 2RL0A 2JGXA 2EC3A 1NWVA 2WIIC 2MCYA 1OK9A 3GXEA 3KZJA 4AYMA 2G7IA 2CG6A 3ZD2A 3IU3I 4C16A 1TPGA 2ERJA 4PZ5A 2YRAA 2BZMA 2V8EA 1HCCA 1GKNA 2W80A 3INBC 3TVJA 1C1ZA 4YNXA 3OEDC 4A5WB 1GPZA 1TPNA 3MQLA 2JGWA 1QUBA 1OJWA 2CKUA 4MUCA 3NFPI 2KRIA 5HZPB 1H2QP 3T5OA 2B5ID 1GHQB 3IX0A 3RJ3D 1SRZA 4B2RA 2UWNA 1Z92B 1VVCA 2XRDA 2YBYA 4K12A 4AYDA 4AYIA 1LY2A 4F4OC 2W81A
chains in the Genus database with same CATH superfamily
5I0QB 3GOVA 3ERBA 3KXVA 4LOSA 3EJHA 1E88A 2QY0A 2RKZA 3R62A 3FGTA 5HYPA 1OK2A 1MD7A 4KKDA 1PPQA 1OK3A 2MCZA 3SW0X 2IZ4A 1GKGA 3ZD1A 1FBRA 3CALA 1VVDA 1ELVA 1E5GA 3WSXA 4ONTD 2XWJI 1H03P 4B2SA 1U5MA 4N7EA 1G4GA 2XWBF 4LOTA 1O9AA 1QO6A 1H04P 1OJVA 1Q3XA 1HFHA 1ZJKA 4FXGG 2Y8TA 5HYTB 3O8EB 1QGBA 3F6KA 3K3TA 2CG7A 4JHSA 1CKLA 2I2LA 3FGRA 2XRBA 1HFIA 1E8BA 4CSYA 3L89M 3M7PA 4BWCA 5DN5A 4J38B 4DJZA 3ZRZA 5DN4A 2A55A 3VWOA 3CI0J 3OXUD 1OJYA 1H2PP 2XQWC 2EHFA 2IZ3A 3OP8A 4AYEA 1OK1A 4MSLA 1TPMA 5FO8C 1G4FA 2JRAA 2LOJA 5HYUB 5JPMG 4WJG2 3WSYA 4APLA 2RLPA 1UOTP 4ZH1D 4IGDA 2KMSA 2X2ZA 2RLQA 2Y8SA 2RKYA 2O39C 1MD8A 1SS2A 2RL0A 2JGXA 2EC3A 1NWVA 2WIIC 2MCYA 1OK9A 3GXEA 3KZJA 3ZLDA 4AYMA 2G7IA 2CG6A 3ZD2A 3IU3I 4C16A 1TPGA 2ERJA 4PZ5A 1RLHA 2YRAA 2BZMA 2V8EA 1HCCA 1GKNA 2W80A 3INBC 3TVJA 1C1ZA 4YNXA 3OEDC 4A5WB 1GPZA 3NJAA 1TPNA 3MQLA 4YIZA 2JGWA 1QUBA 2Y8RA 3ZLEA 1OJWA 4PO7A 2CKUA 4MUCA 3NFPI 2KRIA 5HZPB 1H2QP 3T5OA 2B5ID 1GHQB 3IX0A 3RJ3D 1SRZA 4B2RA 2UWNA 1Z92B 1VVCA 2XRDA 2YBYA 4K12A 4AYDA 4AYIA 2ZYCA 1LY2A 4F4OC 2W81A
chains in the Genus database with same CATH topology
5I0QB 3GOVA 3ERBA 3KXVA 4LOSA 3EJHA 1E88A 2QY0A 2RKZA 3R62A 5HYPA 1OK2A 1MD7A 4KKDA 1PPQA 1OK3A 2MCZA 3SW0X 2IZ4A 1GKGA 3ZD1A 1FBRA 3CALA 1VVDA 1ELVA 1E5GA 4ONTD 2XWJI 1H03P 4B2SA 1U5MA 1G4GA 2XWBF 4LOTA 1O9AA 1QO6A 1H04P 1OJVA 1Q3XA 1HFHA 1ZJKA 4FXGG 5HYTB 3O8EB 1QGBA 2CG7A 4JHSA 1CKLA 2XRBA 1HFIA 1E8BA 4CSYA 3L89M 3M7PA 4DJZA 4J38B 3ZRZA 2A55A 3OXUD 1OJYA 1H2PP 2XQWC 2EHFA 2IZ3A 3OP8A 4AYEA 1OK1A 1TPMA 5FO8C 1G4FA 2JRAA 2LOJA 5HYUB 5JPMG 4WJG2 4ZH1D 2RLPA 1UOTP 4IGDA 2KMSA 2RLQA 2RKYA 2O39C 1MD8A 1SS2A 2RL0A 2JGXA 2EC3A 1NWVA 2WIIC 2MCYA 1OK9A 3GXEA 3KZJA 4AYMA 2G7IA 2CG6A 3ZD2A 3IU3I 4C16A 1TPGA 2ERJA 4PZ5A 2YRAA 2BZMA 2V8EA 1HCCA 1GKNA 2W80A 3INBC 3TVJA 1C1ZA 4YNXA 3OEDC 4A5WB 1GPZA 1TPNA 3MQLA 2JGWA 1QUBA 1OJWA 2CKUA 4MUCA 3NFPI 2KRIA 5HZPB 1H2QP 3T5OA 2B5ID 1GHQB 3IX0A 3RJ3D 1SRZA 4B2RA 2UWNA 1Z92B 1VVCA 2XRDA 2YBYA 4K12A 4AYDA 4AYIA 1LY2A 4F4OC 2W81A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5I0Q B;  3GOV A;  3ERB A;  3KXV A;  4LOS A;  3EJH A;  1E88 A;  2QY0 A;  2RKZ A;  3R62 A;  5HYP A;  1OK2 A;  1MD7 A;  4KKD A;  1PPQ A;  1OK3 A;  2MCZ A;  3SW0 X;  2IZ4 A;  1GKG A;  3ZD1 A;  1FBR A;  3CAL A;  1VVD A;  1ELV A;  1E5G A;  4ONT D;  2XWJ I;  1H03 P;  4B2S A;  1U5M A;  1G4G A;  2XWB F;  4LOT A;  1O9A A;  1QO6 A;  1H04 P;  1OJV A;  1Q3X A;  1HFH A;  1ZJK A;  4FXG G;  5HYT B;  3O8E B;  1QGB A;  2CG7 A;  4JHS A;  1CKL A;  2XRB A;  1HFI A;  1E8B A;  4CSY A;  3L89 M;  3M7P A;  4DJZ A;  4J38 B;  3ZRZ A;  2A55 A;  3OXU D;  1OJY A;  1H2P P;  2XQW C;  2EHF A;  2IZ3 A;  3OP8 A;  4AYE A;  1OK1 A;  1TPM A;  5FO8 C;  1G4F A;  2JRA A;  2LOJ A;  5HYU B;  5JPM G;  4WJG 2;  4ZH1 D;  2RLP A;  1UOT P;  4IGD A;  2KMS A;  2RLQ A;  2RKY A;  2O39 C;  1MD8 A;  1SS2 A;  2RL0 A;  2JGX A;  2EC3 A;  1NWV A;  2WII C;  2MCY A;  1OK9 A;  3GXE A;  3KZJ A;  4AYM A;  2G7I A;  2CG6 A;  3ZD2 A;  3IU3 I;  4C16 A;  1TPG A;  2ERJ A;  4PZ5 A;  2YRA A;  2BZM A;  2V8E A;  1HCC A;  1GKN A;  2W80 A;  3INB C;  3TVJ A;  1C1Z A;  4YNX A;  3OED C;  4A5W B;  1GPZ A;  1TPN A;  3MQL A;  2JGW A;  1QUB A;  1OJW A;  2CKU A;  4MUC A;  3NFP I;  2KRI A;  5HZP B;  1H2Q P;  3T5O A;  2B5I D;  1GHQ B;  3IX0 A;  3RJ3 D;  1SRZ A;  4B2R A;  2UWN A;  1Z92 B;  1VVC A;  2XRD A;  2YBY A;  4K12 A;  4AYD A;  4AYI A;  1LY2 A;  4F4O C;  2W81 A; 
#chains in the Genus database with same CATH topology
 5I0Q B;  3GOV A;  3ERB A;  3KXV A;  4LOS A;  3EJH A;  1E88 A;  2QY0 A;  2RKZ A;  3R62 A;  3FGT A;  5HYP A;  1OK2 A;  1MD7 A;  4KKD A;  1PPQ A;  1OK3 A;  2MCZ A;  3SW0 X;  2IZ4 A;  1GKG A;  3ZD1 A;  1FBR A;  3CAL A;  1VVD A;  1ELV A;  1E5G A;  3WSX A;  4ONT D;  2XWJ I;  1H03 P;  4B2S A;  1U5M A;  4N7E A;  1G4G A;  2XWB F;  4LOT A;  1O9A A;  1QO6 A;  1H04 P;  1OJV A;  1Q3X A;  1HFH A;  1ZJK A;  4FXG G;  2Y8T A;  5HYT B;  3O8E B;  1QGB A;  3F6K A;  3K3T A;  2CG7 A;  4JHS A;  1CKL A;  2I2L A;  3FGR A;  2XRB A;  1HFI A;  1E8B A;  4CSY A;  3L89 M;  3M7P A;  4BWC A;  5DN5 A;  4J38 B;  4DJZ A;  3ZRZ A;  5DN4 A;  2A55 A;  3VWO A;  3CI0 J;  3OXU D;  1OJY A;  1H2P P;  2XQW C;  2EHF A;  2IZ3 A;  3OP8 A;  4AYE A;  1OK1 A;  4MSL A;  1TPM A;  5FO8 C;  1G4F A;  2JRA A;  2LOJ A;  5HYU B;  5JPM G;  4WJG 2;  3WSY A;  4APL A;  2RLP A;  1UOT P;  4ZH1 D;  4IGD A;  2KMS A;  2X2Z A;  2RLQ A;  2Y8S A;  2RKY A;  2O39 C;  1MD8 A;  1SS2 A;  2RL0 A;  2JGX A;  2EC3 A;  1NWV A;  2WII C;  2MCY A;  1OK9 A;  3GXE A;  3KZJ A;  3ZLD A;  4AYM A;  2G7I A;  2CG6 A;  3ZD2 A;  3IU3 I;  4C16 A;  1TPG A;  2ERJ A;  4PZ5 A;  1RLH A;  2YRA A;  2BZM A;  2V8E A;  1HCC A;  1GKN A;  2W80 A;  3INB C;  3TVJ A;  1C1Z A;  4YNX A;  3OED C;  4A5W B;  1GPZ A;  3NJA A;  1TPN A;  3MQL A;  4YIZ A;  2JGW A;  1QUB A;  2Y8R A;  3ZLE A;  1OJW A;  4PO7 A;  2CKU A;  4MUC A;  3NFP I;  2KRI A;  5HZP B;  1H2Q P;  3T5O A;  2B5I D;  1GHQ B;  3IX0 A;  3RJ3 D;  1SRZ A;  4B2R A;  2UWN A;  1Z92 B;  1VVC A;  2XRD A;  2YBY A;  4K12 A;  4AYD A;  4AYI A;  2ZYC A;  1LY2 A;  4F4O C;  2W81 A; 
#chains in the Genus database with same CATH homology
 5I0Q B;  3GOV A;  3ERB A;  3KXV A;  4LOS A;  3EJH A;  1E88 A;  2QY0 A;  2RKZ A;  3R62 A;  5HYP A;  1OK2 A;  1MD7 A;  4KKD A;  1PPQ A;  1OK3 A;  2MCZ A;  3SW0 X;  2IZ4 A;  1GKG A;  3ZD1 A;  1FBR A;  3CAL A;  1VVD A;  1ELV A;  1E5G A;  4ONT D;  2XWJ I;  1H03 P;  4B2S A;  1U5M A;  1G4G A;  2XWB F;  4LOT A;  1O9A A;  1QO6 A;  1H04 P;  1OJV A;  1Q3X A;  1HFH A;  1ZJK A;  4FXG G;  5HYT B;  3O8E B;  1QGB A;  2CG7 A;  4JHS A;  1CKL A;  2XRB A;  1HFI A;  1E8B A;  4CSY A;  3L89 M;  3M7P A;  4DJZ A;  4J38 B;  3ZRZ A;  2A55 A;  3OXU D;  1OJY A;  1H2P P;  2XQW C;  2EHF A;  2IZ3 A;  3OP8 A;  4AYE A;  1OK1 A;  1TPM A;  5FO8 C;  1G4F A;  2JRA A;  2LOJ A;  5HYU B;  5JPM G;  4WJG 2;  4ZH1 D;  2RLP A;  1UOT P;  4IGD A;  2KMS A;  2RLQ A;  2RKY A;  2O39 C;  1MD8 A;  1SS2 A;  2RL0 A;  2JGX A;  2EC3 A;  1NWV A;  2WII C;  2MCY A;  1OK9 A;  3GXE A;  3KZJ A;  4AYM A;  2G7I A;  2CG6 A;  3ZD2 A;  3IU3 I;  4C16 A;  1TPG A;  2ERJ A;  4PZ5 A;  2YRA A;  2BZM A;  2V8E A;  1HCC A;  1GKN A;  2W80 A;  3INB C;  3TVJ A;  1C1Z A;  4YNX A;  3OED C;  4A5W B;  1GPZ A;  1TPN A;  3MQL A;  2JGW A;  1QUB A;  1OJW A;  2CKU A;  4MUC A;  3NFP I;  2KRI A;  5HZP B;  1H2Q P;  3T5O A;  2B5I D;  1GHQ B;  3IX0 A;  3RJ3 D;  1SRZ A;  4B2R A;  2UWN A;  1Z92 B;  1VVC A;  2XRD A;  2YBY A;  4K12 A;  4AYD A;  4AYI A;  1LY2 A;  4F4O C;  2W81 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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