2JGXA

Structure of ccp module 7 of complement factor h - the amd not at risk varient (402y)
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
61
structure length
61
Chain Sequence
LRKCYFPYLENGYNQNYGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
pubmed doi rcsb
molecule tags Immune response
source organism Homo sapiens
molecule keywords COMPLEMENT FACTOR H
total genus 10
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2007-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2jgxA00
1HCCA 4DJZA 4ONTD 1H03P 1H2PP 1ELVA 2WIIC 3SW0X 3OP8A 4LOSA 2A55A 3KZJA 4ZH1D 1PPQA 3CALA 2XRDA 4AYIA 1OK2A 2JGXA 2XQWC 3R62A 2KMSA 2UWNA 2CG7A 2BZMA 2QY0A 1VVDA 4WJG2 1TPGA 2IZ4A 1NWVA 2O39C 3ZD1A 4A5WB 1OK1A 1TPMA 4B2SA 4C16A 1C1ZA 1QO6A 2W80A 3O8EB 2ERJA 2MCYA 1OJYA 1OK3A 1OJVA 1O9AA 4JHSA 2JRAA 5FO8C 3GXEA 2G7IA 1H2QP 5HYPA 3ZD2A 4PZ5A 2KRIA 2JGWA 2MCZA 3ZRZA 2XWBF 2V8EA 1MD8A 5I0QB 3EJHA 3L89M 2IZ3A 1LY2A 3ERBA 1UOTP 1SRZA 1QUBA 1MD7A 3MQLA 1Q3XA 4CSYA 4YNXA 1H04P 4LOTA 3IU3I 4KKDA 4J38B 1VVCA 1HFIA 5HZPB 1ZJKA 3GOVA 3IX0A 2RKZA 3RJ3D 1U5MA 2XRBA 2CKUA 1TPNA 4K12A 1OJWA 5HYUB 2RKYA 2RL0A 1E8BA 1FBRA 2LOJA 1G4GA 4MUCA 1GKGA 2B5ID 3NFPI 3KXVA 5JPMG 3OXUD 5HYTB 4IGDA 4AYMA 4B2RA 1CKLA 2RLPA 1E5GA 2YBYA 2EC3A 2RLQA 1OK9A 1E88A 1HFHA 3INBC 4F4OC 2YRAA 3TVJA 1Z92B 3OEDC 3T5OA 1GHQB 1G4FA 4FXGG 4AYDA 2EHFA 2XWJI 1QGBA 4AYEA 1GKNA 2W81A 1GPZA 2CG6A 3M7PA 1SS2A
chains in the Genus database with same CATH superfamily
1HCCA 4DJZA 4ONTD 1H03P 1H2PP 2Y8RA 1ELVA 2WIIC 3SW0X 3CI0J 3OP8A 4LOSA 4YIZA 2A55A 3KZJA 4ZH1D 4BWCA 1PPQA 3CALA 2XRDA 4AYIA 1OK2A 2JGXA 5DN5A 2XQWC 3R62A 4N7EA 2KMSA 2UWNA 2CG7A 2BZMA 4MSLA 2QY0A 4APLA 1VVDA 4WJG2 1TPGA 2IZ4A 1NWVA 2O39C 3ZD1A 4A5WB 1OK1A 1TPMA 4B2SA 4C16A 1C1ZA 1QO6A 2W80A 2X2ZA 3O8EB 2ERJA 2MCYA 1OJYA 5DN4A 1OK3A 3F6KA 3ZLEA 1OJVA 1O9AA 4JHSA 2JRAA 4PO7A 5FO8C 3GXEA 2G7IA 1H2QP 5HYPA 2I2LA 3ZD2A 4PZ5A 2KRIA 2JGWA 2MCZA 3ZRZA 1RLHA 2XWBF 2V8EA 1MD8A 5I0QB 3EJHA 3L89M 2IZ3A 3FGTA 1LY2A 3ERBA 1UOTP 1SRZA 1QUBA 1MD7A 3MQLA 1Q3XA 4CSYA 4YNXA 3NJAA 1H04P 4LOTA 3IU3I 4KKDA 4J38B 1VVCA 1HFIA 5HZPB 1ZJKA 3GOVA 3IX0A 2RKZA 3RJ3D 1U5MA 2XRBA 2CKUA 1TPNA 4K12A 1OJWA 5HYUB 2RKYA 2RL0A 1E8BA 1FBRA 2LOJA 1G4GA 4MUCA 1GKGA 2B5ID 3NFPI 3KXVA 5JPMG 3OXUD 2ZYCA 5HYTB 4IGDA 4AYMA 3WSXA 4B2RA 2Y8TA 1CKLA 2RLPA 3VWOA 1E5GA 2YBYA 3WSYA 2EC3A 2RLQA 1OK9A 1E88A 1HFHA 3INBC 4F4OC 2YRAA 3TVJA 1Z92B 3OEDC 3T5OA 1GHQB 1G4FA 4FXGG 4AYDA 2EHFA 2Y8SA 2XWJI 1QGBA 4AYEA 1GKNA 2W81A 1GPZA 2CG6A 3FGRA 3K3TA 3M7PA 3ZLDA 1SS2A
chains in the Genus database with same CATH topology
1HCCA 4DJZA 4ONTD 1H03P 1H2PP 1ELVA 2WIIC 3SW0X 3OP8A 4LOSA 2A55A 3KZJA 4ZH1D 1PPQA 3CALA 2XRDA 4AYIA 1OK2A 2JGXA 2XQWC 3R62A 2KMSA 2UWNA 2CG7A 2BZMA 2QY0A 1VVDA 4WJG2 1TPGA 2IZ4A 1NWVA 2O39C 3ZD1A 4A5WB 1OK1A 1TPMA 4B2SA 4C16A 1C1ZA 1QO6A 2W80A 3O8EB 2ERJA 2MCYA 1OJYA 1OK3A 1OJVA 1O9AA 4JHSA 2JRAA 5FO8C 3GXEA 2G7IA 1H2QP 5HYPA 3ZD2A 4PZ5A 2KRIA 2JGWA 2MCZA 3ZRZA 2XWBF 2V8EA 1MD8A 5I0QB 3EJHA 3L89M 2IZ3A 1LY2A 3ERBA 1UOTP 1SRZA 1QUBA 1MD7A 3MQLA 1Q3XA 4CSYA 4YNXA 1H04P 4LOTA 3IU3I 4KKDA 4J38B 1VVCA 1HFIA 5HZPB 1ZJKA 3GOVA 3IX0A 2RKZA 3RJ3D 1U5MA 2XRBA 2CKUA 1TPNA 4K12A 1OJWA 5HYUB 2RKYA 2RL0A 1E8BA 1FBRA 2LOJA 1G4GA 4MUCA 1GKGA 2B5ID 3NFPI 3KXVA 5JPMG 3OXUD 5HYTB 4IGDA 4AYMA 4B2RA 1CKLA 2RLPA 1E5GA 2YBYA 2EC3A 2RLQA 1OK9A 1E88A 1HFHA 3INBC 4F4OC 2YRAA 3TVJA 1Z92B 3OEDC 3T5OA 1GHQB 1G4FA 4FXGG 4AYDA 2EHFA 2XWJI 1QGBA 4AYEA 1GKNA 2W81A 1GPZA 2CG6A 3M7PA 1SS2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HCC A;  4DJZ A;  4ONT D;  1H03 P;  1H2P P;  1ELV A;  2WII C;  3SW0 X;  3OP8 A;  4LOS A;  2A55 A;  3KZJ A;  4ZH1 D;  1PPQ A;  3CAL A;  2XRD A;  4AYI A;  1OK2 A;  2JGX A;  2XQW C;  3R62 A;  2KMS A;  2UWN A;  2CG7 A;  2BZM A;  2QY0 A;  1VVD A;  4WJG 2;  1TPG A;  2IZ4 A;  1NWV A;  2O39 C;  3ZD1 A;  4A5W B;  1OK1 A;  1TPM A;  4B2S A;  4C16 A;  1C1Z A;  1QO6 A;  2W80 A;  3O8E B;  2ERJ A;  2MCY A;  1OJY A;  1OK3 A;  1OJV A;  1O9A A;  4JHS A;  2JRA A;  5FO8 C;  3GXE A;  2G7I A;  1H2Q P;  5HYP A;  3ZD2 A;  4PZ5 A;  2KRI A;  2JGW A;  2MCZ A;  3ZRZ A;  2XWB F;  2V8E A;  1MD8 A;  5I0Q B;  3EJH A;  3L89 M;  2IZ3 A;  1LY2 A;  3ERB A;  1UOT P;  1SRZ A;  1QUB A;  1MD7 A;  3MQL A;  1Q3X A;  4CSY A;  4YNX A;  1H04 P;  4LOT A;  3IU3 I;  4KKD A;  4J38 B;  1VVC A;  1HFI A;  5HZP B;  1ZJK A;  3GOV A;  3IX0 A;  2RKZ A;  3RJ3 D;  1U5M A;  2XRB A;  2CKU A;  1TPN A;  4K12 A;  1OJW A;  5HYU B;  2RKY A;  2RL0 A;  1E8B A;  1FBR A;  2LOJ A;  1G4G A;  4MUC A;  1GKG A;  2B5I D;  3NFP I;  3KXV A;  5JPM G;  3OXU D;  5HYT B;  4IGD A;  4AYM A;  4B2R A;  1CKL A;  2RLP A;  1E5G A;  2YBY A;  2EC3 A;  2RLQ A;  1OK9 A;  1E88 A;  1HFH A;  3INB C;  4F4O C;  2YRA A;  3TVJ A;  1Z92 B;  3OED C;  3T5O A;  1GHQ B;  1G4F A;  4FXG G;  4AYD A;  2EHF A;  2XWJ I;  1QGB A;  4AYE A;  1GKN A;  2W81 A;  1GPZ A;  2CG6 A;  3M7P A;  1SS2 A; 
#chains in the Genus database with same CATH topology
 1HCC A;  4DJZ A;  4ONT D;  1H03 P;  1H2P P;  2Y8R A;  1ELV A;  2WII C;  3SW0 X;  3CI0 J;  3OP8 A;  4LOS A;  4YIZ A;  2A55 A;  3KZJ A;  4ZH1 D;  4BWC A;  1PPQ A;  3CAL A;  2XRD A;  4AYI A;  1OK2 A;  2JGX A;  5DN5 A;  2XQW C;  3R62 A;  4N7E A;  2KMS A;  2UWN A;  2CG7 A;  2BZM A;  4MSL A;  2QY0 A;  4APL A;  1VVD A;  4WJG 2;  1TPG A;  2IZ4 A;  1NWV A;  2O39 C;  3ZD1 A;  4A5W B;  1OK1 A;  1TPM A;  4B2S A;  4C16 A;  1C1Z A;  1QO6 A;  2W80 A;  2X2Z A;  3O8E B;  2ERJ A;  2MCY A;  1OJY A;  5DN4 A;  1OK3 A;  3F6K A;  3ZLE A;  1OJV A;  1O9A A;  4JHS A;  2JRA A;  4PO7 A;  5FO8 C;  3GXE A;  2G7I A;  1H2Q P;  5HYP A;  2I2L A;  3ZD2 A;  4PZ5 A;  2KRI A;  2JGW A;  2MCZ A;  3ZRZ A;  1RLH A;  2XWB F;  2V8E A;  1MD8 A;  5I0Q B;  3EJH A;  3L89 M;  2IZ3 A;  3FGT A;  1LY2 A;  3ERB A;  1UOT P;  1SRZ A;  1QUB A;  1MD7 A;  3MQL A;  1Q3X A;  4CSY A;  4YNX A;  3NJA A;  1H04 P;  4LOT A;  3IU3 I;  4KKD A;  4J38 B;  1VVC A;  1HFI A;  5HZP B;  1ZJK A;  3GOV A;  3IX0 A;  2RKZ A;  3RJ3 D;  1U5M A;  2XRB A;  2CKU A;  1TPN A;  4K12 A;  1OJW A;  5HYU B;  2RKY A;  2RL0 A;  1E8B A;  1FBR A;  2LOJ A;  1G4G A;  4MUC A;  1GKG A;  2B5I D;  3NFP I;  3KXV A;  5JPM G;  3OXU D;  2ZYC A;  5HYT B;  4IGD A;  4AYM A;  3WSX A;  4B2R A;  2Y8T A;  1CKL A;  2RLP A;  3VWO A;  1E5G A;  2YBY A;  3WSY A;  2EC3 A;  2RLQ A;  1OK9 A;  1E88 A;  1HFH A;  3INB C;  4F4O C;  2YRA A;  3TVJ A;  1Z92 B;  3OED C;  3T5O A;  1GHQ B;  1G4F A;  4FXG G;  4AYD A;  2EHF A;  2Y8S A;  2XWJ I;  1QGB A;  4AYE A;  1GKN A;  2W81 A;  1GPZ A;  2CG6 A;  3FGR A;  3K3T A;  3M7P A;  3ZLD A;  1SS2 A; 
#chains in the Genus database with same CATH homology
 1HCC A;  4DJZ A;  4ONT D;  1H03 P;  1H2P P;  1ELV A;  2WII C;  3SW0 X;  3OP8 A;  4LOS A;  2A55 A;  3KZJ A;  4ZH1 D;  1PPQ A;  3CAL A;  2XRD A;  4AYI A;  1OK2 A;  2JGX A;  2XQW C;  3R62 A;  2KMS A;  2UWN A;  2CG7 A;  2BZM A;  2QY0 A;  1VVD A;  4WJG 2;  1TPG A;  2IZ4 A;  1NWV A;  2O39 C;  3ZD1 A;  4A5W B;  1OK1 A;  1TPM A;  4B2S A;  4C16 A;  1C1Z A;  1QO6 A;  2W80 A;  3O8E B;  2ERJ A;  2MCY A;  1OJY A;  1OK3 A;  1OJV A;  1O9A A;  4JHS A;  2JRA A;  5FO8 C;  3GXE A;  2G7I A;  1H2Q P;  5HYP A;  3ZD2 A;  4PZ5 A;  2KRI A;  2JGW A;  2MCZ A;  3ZRZ A;  2XWB F;  2V8E A;  1MD8 A;  5I0Q B;  3EJH A;  3L89 M;  2IZ3 A;  1LY2 A;  3ERB A;  1UOT P;  1SRZ A;  1QUB A;  1MD7 A;  3MQL A;  1Q3X A;  4CSY A;  4YNX A;  1H04 P;  4LOT A;  3IU3 I;  4KKD A;  4J38 B;  1VVC A;  1HFI A;  5HZP B;  1ZJK A;  3GOV A;  3IX0 A;  2RKZ A;  3RJ3 D;  1U5M A;  2XRB A;  2CKU A;  1TPN A;  4K12 A;  1OJW A;  5HYU B;  2RKY A;  2RL0 A;  1E8B A;  1FBR A;  2LOJ A;  1G4G A;  4MUC A;  1GKG A;  2B5I D;  3NFP I;  3KXV A;  5JPM G;  3OXU D;  5HYT B;  4IGD A;  4AYM A;  4B2R A;  1CKL A;  2RLP A;  1E5G A;  2YBY A;  2EC3 A;  2RLQ A;  1OK9 A;  1E88 A;  1HFH A;  3INB C;  4F4O C;  2YRA A;  3TVJ A;  1Z92 B;  3OED C;  3T5O A;  1GHQ B;  1G4F A;  4FXG G;  4AYD A;  2EHF A;  2XWJ I;  1QGB A;  4AYE A;  1GKN A;  2W81 A;  1GPZ A;  2CG6 A;  3M7P A;  1SS2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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