2RLPA

Nmr structure of ccp modules 1-2 of complement factor h
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
123
structure length
123
Chain Sequence
DCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
source organism Homo sapiens
publication title Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
pubmed doi rcsb
molecule keywords Complement factor H
total genus 22
structure length 123
sequence length 123
ec nomenclature
pdb deposition date 2007-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2rlpA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2rlpA01
1Q3XA 2RLQA 1MD7A 2YBYA 1OJWA 1OK1A 3GXEA 4DJZA 1E88A 4YNXA 1SS2A 1HCCA 4ONTD 1MD8A 1H2QP 3INBC 1TPMA 4ZH1D 1QO6A 5FO8C 5HYTB 3ZD1A 3TVJA 3R62A 1NWVA 3L89M 4CSYA 3IU3I 2IZ3A 3M7PA 1GPZA 2EHFA 1TPGA 2CG6A 1U5MA 2CG7A 1OK3A 4KKDA 3NFPI 1ELVA 2RKZA 4B2SA 1H03P 1G4GA 4AYMA 1HFHA 2W80A 3RJ3D 1C1ZA 2UWNA 4AYDA 2MCYA 2G7IA 1SRZA 1E5GA 4AYEA 1O9AA 3T5OA 4FXGG 3ZD2A 1H2PP 2KRIA 4J38B 2JGWA 4WJG2 5HZPB 3OEDC 5HYPA 1PPQA 3EJHA 2XRDA 1QUBA 4B2RA 2O39C 4LOSA 1LY2A 2WIIC 1GKNA 2IZ4A 1ZJKA 5I0QB 5JPMG 3SW0X 1OK9A 2ERJA 1H04P 2W81A 2RKYA 1GKGA 3IX0A 3O8EB 1CKLA 3OP8A 1OJVA 2RLPA 4A5WB 3CALA 2YRAA 4K12A 2XWJI 2MCZA 2BZMA 3KXVA 2RL0A 4IGDA 4MUCA 2V8EA 2EC3A 4JHSA 4F4OC 2JRAA 2XWBF 1G4FA 2KMSA 1E8BA 2XRBA 1TPNA 3GOVA 3MQLA 3ERBA 3KZJA 4C16A 1FBRA 2A55A 4LOTA 4AYIA 3ZRZA 1QGBA 4PZ5A 2CKUA 2LOJA 2B5ID 1OJYA 3OXUD 2XQWC 1Z92B 1VVCA 5HYUB 1HFIA 1UOTP 2JGXA 2QY0A 1GHQB 1OK2A 1VVDA
chains in the Genus database with same CATH superfamily
1Q3XA 2RLQA 1MD7A 2YBYA 1OJWA 1OK1A 3GXEA 4DJZA 1E88A 4YNXA 1SS2A 1HCCA 3K3TA 1MD8A 4ONTD 1H2QP 3INBC 1TPMA 4ZH1D 1QO6A 5FO8C 5HYTB 3ZD1A 3TVJA 3R62A 1NWVA 3L89M 4CSYA 3IU3I 2IZ3A 3M7PA 1GPZA 2EHFA 1TPGA 2CG6A 1U5MA 2CG7A 5DN4A 1OK3A 4KKDA 3NFPI 1ELVA 2RKZA 4B2SA 1H03P 1G4GA 2Y8RA 4AYMA 4YIZA 1HFHA 2W80A 3CI0J 1C1ZA 2UWNA 3RJ3D 4AYDA 2MCYA 2G7IA 1SRZA 1E5GA 4AYEA 1O9AA 3T5OA 4FXGG 2I2LA 3ZD2A 1H2PP 2KRIA 4J38B 2JGWA 4WJG2 5HZPB 3OEDC 5HYPA 1PPQA 3EJHA 3NJAA 2XRDA 1QUBA 4B2RA 2O39C 4LOSA 1LY2A 2WIIC 1GKNA 2IZ4A 1ZJKA 5I0QB 5JPMG 3WSYA 3SW0X 1OK9A 2ERJA 1H04P 2W81A 2RKYA 3WSXA 1GKGA 3IX0A 3O8EB 4PO7A 1CKLA 3OP8A 1OJVA 2RLPA 3ZLEA 4A5WB 3CALA 2YRAA 4N7EA 4K12A 2ZYCA 2XWJI 2MCZA 2BZMA 3KXVA 2RL0A 4IGDA 4MUCA 3FGRA 2V8EA 2EC3A 4JHSA 4F4OC 2JRAA 2XWBF 1G4FA 2KMSA 5DN5A 3FGTA 1E8BA 2XRBA 1TPNA 3GOVA 1RLHA 2Y8SA 3MQLA 3ERBA 3KZJA 2Y8TA 4C16A 1FBRA 2A55A 4LOTA 4AYIA 3ZRZA 1QGBA 4PZ5A 2CKUA 2LOJA 2B5ID 1OJYA 3OXUD 4APLA 2XQWC 1Z92B 2X2ZA 1VVCA 4BWCA 5HYUB 3ZLDA 1HFIA 1UOTP 2JGXA 3VWOA 2QY0A 4MSLA 3F6KA 1GHQB 1OK2A 1VVDA
chains in the Genus database with same CATH topology
1Q3XA 2RLQA 1MD7A 2YBYA 1OJWA 1OK1A 3GXEA 4DJZA 1E88A 4YNXA 1SS2A 1HCCA 4ONTD 1MD8A 1H2QP 3INBC 1TPMA 4ZH1D 1QO6A 5FO8C 5HYTB 3ZD1A 3TVJA 3R62A 1NWVA 3L89M 4CSYA 3IU3I 2IZ3A 3M7PA 1GPZA 2EHFA 1TPGA 2CG6A 1U5MA 2CG7A 1OK3A 4KKDA 3NFPI 1ELVA 2RKZA 4B2SA 1H03P 1G4GA 4AYMA 1HFHA 2W80A 3RJ3D 1C1ZA 2UWNA 4AYDA 2MCYA 2G7IA 1SRZA 1E5GA 4AYEA 1O9AA 3T5OA 4FXGG 3ZD2A 1H2PP 2KRIA 4J38B 2JGWA 4WJG2 5HZPB 3OEDC 5HYPA 1PPQA 3EJHA 2XRDA 1QUBA 4B2RA 2O39C 4LOSA 1LY2A 2WIIC 1GKNA 2IZ4A 1ZJKA 5I0QB 5JPMG 3SW0X 1OK9A 2ERJA 1H04P 2W81A 2RKYA 1GKGA 3IX0A 3O8EB 1CKLA 3OP8A 1OJVA 2RLPA 4A5WB 3CALA 2YRAA 4K12A 2XWJI 2MCZA 2BZMA 3KXVA 2RL0A 4IGDA 4MUCA 2V8EA 2EC3A 4JHSA 4F4OC 2JRAA 2XWBF 1G4FA 2KMSA 1E8BA 2XRBA 1TPNA 3GOVA 3MQLA 3ERBA 3KZJA 4C16A 1FBRA 2A55A 4LOTA 4AYIA 3ZRZA 1QGBA 4PZ5A 2CKUA 2LOJA 2B5ID 1OJYA 3OXUD 2XQWC 1Z92B 1VVCA 5HYUB 1HFIA 1UOTP 2JGXA 2QY0A 1GHQB 1OK2A 1VVDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q3X A;  2RLQ A;  1MD7 A;  2YBY A;  1OJW A;  1OK1 A;  3GXE A;  4DJZ A;  1E88 A;  4YNX A;  1SS2 A;  1HCC A;  4ONT D;  1MD8 A;  1H2Q P;  3INB C;  1TPM A;  4ZH1 D;  1QO6 A;  5FO8 C;  5HYT B;  3ZD1 A;  3TVJ A;  3R62 A;  1NWV A;  3L89 M;  4CSY A;  3IU3 I;  2IZ3 A;  3M7P A;  1GPZ A;  2EHF A;  1TPG A;  2CG6 A;  1U5M A;  2CG7 A;  1OK3 A;  4KKD A;  3NFP I;  1ELV A;  2RKZ A;  4B2S A;  1H03 P;  1G4G A;  4AYM A;  1HFH A;  2W80 A;  3RJ3 D;  1C1Z A;  2UWN A;  4AYD A;  2MCY A;  2G7I A;  1SRZ A;  1E5G A;  4AYE A;  1O9A A;  3T5O A;  4FXG G;  3ZD2 A;  1H2P P;  2KRI A;  4J38 B;  2JGW A;  4WJG 2;  5HZP B;  3OED C;  5HYP A;  1PPQ A;  3EJH A;  2XRD A;  1QUB A;  4B2R A;  2O39 C;  4LOS A;  1LY2 A;  2WII C;  1GKN A;  2IZ4 A;  1ZJK A;  5I0Q B;  5JPM G;  3SW0 X;  1OK9 A;  2ERJ A;  1H04 P;  2W81 A;  2RKY A;  1GKG A;  3IX0 A;  3O8E B;  1CKL A;  3OP8 A;  1OJV A;  2RLP A;  4A5W B;  3CAL A;  2YRA A;  4K12 A;  2XWJ I;  2MCZ A;  2BZM A;  3KXV A;  2RL0 A;  4IGD A;  4MUC A;  2V8E A;  2EC3 A;  4JHS A;  4F4O C;  2JRA A;  2XWB F;  1G4F A;  2KMS A;  1E8B A;  2XRB A;  1TPN A;  3GOV A;  3MQL A;  3ERB A;  3KZJ A;  4C16 A;  1FBR A;  2A55 A;  4LOT A;  4AYI A;  3ZRZ A;  1QGB A;  4PZ5 A;  2CKU A;  2LOJ A;  2B5I D;  1OJY A;  3OXU D;  2XQW C;  1Z92 B;  1VVC A;  5HYU B;  1HFI A;  1UOT P;  2JGX A;  2QY0 A;  1GHQ B;  1OK2 A;  1VVD A; 
#chains in the Genus database with same CATH topology
 1Q3X A;  2RLQ A;  1MD7 A;  2YBY A;  1OJW A;  1OK1 A;  3GXE A;  4DJZ A;  1E88 A;  4YNX A;  1SS2 A;  1HCC A;  3K3T A;  1MD8 A;  4ONT D;  1H2Q P;  3INB C;  1TPM A;  4ZH1 D;  1QO6 A;  5FO8 C;  5HYT B;  3ZD1 A;  3TVJ A;  3R62 A;  1NWV A;  3L89 M;  4CSY A;  3IU3 I;  2IZ3 A;  3M7P A;  1GPZ A;  2EHF A;  1TPG A;  2CG6 A;  1U5M A;  2CG7 A;  5DN4 A;  1OK3 A;  4KKD A;  3NFP I;  1ELV A;  2RKZ A;  4B2S A;  1H03 P;  1G4G A;  2Y8R A;  4AYM A;  4YIZ A;  1HFH A;  2W80 A;  3CI0 J;  1C1Z A;  2UWN A;  3RJ3 D;  4AYD A;  2MCY A;  2G7I A;  1SRZ A;  1E5G A;  4AYE A;  1O9A A;  3T5O A;  4FXG G;  2I2L A;  3ZD2 A;  1H2P P;  2KRI A;  4J38 B;  2JGW A;  4WJG 2;  5HZP B;  3OED C;  5HYP A;  1PPQ A;  3EJH A;  3NJA A;  2XRD A;  1QUB A;  4B2R A;  2O39 C;  4LOS A;  1LY2 A;  2WII C;  1GKN A;  2IZ4 A;  1ZJK A;  5I0Q B;  5JPM G;  3WSY A;  3SW0 X;  1OK9 A;  2ERJ A;  1H04 P;  2W81 A;  2RKY A;  3WSX A;  1GKG A;  3IX0 A;  3O8E B;  4PO7 A;  1CKL A;  3OP8 A;  1OJV A;  2RLP A;  3ZLE A;  4A5W B;  3CAL A;  2YRA A;  4N7E A;  4K12 A;  2ZYC A;  2XWJ I;  2MCZ A;  2BZM A;  3KXV A;  2RL0 A;  4IGD A;  4MUC A;  3FGR A;  2V8E A;  2EC3 A;  4JHS A;  4F4O C;  2JRA A;  2XWB F;  1G4F A;  2KMS A;  5DN5 A;  3FGT A;  1E8B A;  2XRB A;  1TPN A;  3GOV A;  1RLH A;  2Y8S A;  3MQL A;  3ERB A;  3KZJ A;  2Y8T A;  4C16 A;  1FBR A;  2A55 A;  4LOT A;  4AYI A;  3ZRZ A;  1QGB A;  4PZ5 A;  2CKU A;  2LOJ A;  2B5I D;  1OJY A;  3OXU D;  4APL A;  2XQW C;  1Z92 B;  2X2Z A;  1VVC A;  4BWC A;  5HYU B;  3ZLD A;  1HFI A;  1UOT P;  2JGX A;  3VWO A;  2QY0 A;  4MSL A;  3F6K A;  1GHQ B;  1OK2 A;  1VVD A; 
#chains in the Genus database with same CATH homology
 1Q3X A;  2RLQ A;  1MD7 A;  2YBY A;  1OJW A;  1OK1 A;  3GXE A;  4DJZ A;  1E88 A;  4YNX A;  1SS2 A;  1HCC A;  4ONT D;  1MD8 A;  1H2Q P;  3INB C;  1TPM A;  4ZH1 D;  1QO6 A;  5FO8 C;  5HYT B;  3ZD1 A;  3TVJ A;  3R62 A;  1NWV A;  3L89 M;  4CSY A;  3IU3 I;  2IZ3 A;  3M7P A;  1GPZ A;  2EHF A;  1TPG A;  2CG6 A;  1U5M A;  2CG7 A;  1OK3 A;  4KKD A;  3NFP I;  1ELV A;  2RKZ A;  4B2S A;  1H03 P;  1G4G A;  4AYM A;  1HFH A;  2W80 A;  3RJ3 D;  1C1Z A;  2UWN A;  4AYD A;  2MCY A;  2G7I A;  1SRZ A;  1E5G A;  4AYE A;  1O9A A;  3T5O A;  4FXG G;  3ZD2 A;  1H2P P;  2KRI A;  4J38 B;  2JGW A;  4WJG 2;  5HZP B;  3OED C;  5HYP A;  1PPQ A;  3EJH A;  2XRD A;  1QUB A;  4B2R A;  2O39 C;  4LOS A;  1LY2 A;  2WII C;  1GKN A;  2IZ4 A;  1ZJK A;  5I0Q B;  5JPM G;  3SW0 X;  1OK9 A;  2ERJ A;  1H04 P;  2W81 A;  2RKY A;  1GKG A;  3IX0 A;  3O8E B;  1CKL A;  3OP8 A;  1OJV A;  2RLP A;  4A5W B;  3CAL A;  2YRA A;  4K12 A;  2XWJ I;  2MCZ A;  2BZM A;  3KXV A;  2RL0 A;  4IGD A;  4MUC A;  2V8E A;  2EC3 A;  4JHS A;  4F4O C;  2JRA A;  2XWB F;  1G4F A;  2KMS A;  1E8B A;  2XRB A;  1TPN A;  3GOV A;  3MQL A;  3ERB A;  3KZJ A;  4C16 A;  1FBR A;  2A55 A;  4LOT A;  4AYI A;  3ZRZ A;  1QGB A;  4PZ5 A;  2CKU A;  2LOJ A;  2B5I D;  1OJY A;  3OXU D;  2XQW C;  1Z92 B;  1VVC A;  5HYU B;  1HFI A;  1UOT P;  2JGX A;  2QY0 A;  1GHQ B;  1OK2 A;  1VVD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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