2RLPA

Nmr structure of ccp modules 1-2 of complement factor h
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
123
structure length
123
Chain Sequence
DCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 22
structure length 123
sequence length 123
ec nomenclature
pdb deposition date 2007-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2rlpA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2rlpA01
1E88A 2EC3A 5FO8C 4AYEA 3GXEA 4C16A 1C1ZA 1ELVA 2YBYA 1H04P 5HYTB 4IGDA 4AYMA 4LOTA 2XWBF 3L89M 3RJ3D 2JGWA 2QY0A 2EHFA 1FBRA 2B5ID 3KXVA 2A55A 2CG7A 2BZMA 4ZH1D 2RL0A 1OK9A 3INBC 4B2SA 1MD8A 2RLPA 2MCZA 2KMSA 5HZPB 1QO6A 2XQWC 4CSYA 1G4FA 4A5WB 1TPGA 2G7IA 2V8EA 2RLQA 1H03P 3OP8A 1GPZA 1Q3XA 2JGXA 2IZ3A 5JPMG 1MD7A 3R62A 2RKYA 3ZD1A 4K12A 1TPMA 3ZD2A 4AYDA 4F4OC 1UOTP 4DJZA 1GKNA 1H2PP 1Z92B 1HFIA 2ERJA 1QUBA 1TPNA 2KRIA 3GOVA 1O9AA 1OJVA 3TVJA 4JHSA 1GHQB 2WIIC 1SS2A 3OEDC 1VVCA 3SW0X 3ZRZA 2W81A 1G4GA 1GKGA 2CKUA 4KKDA 4YNXA 3O8EB 3CALA 2XWJI 1OK1A 1NWVA 4FXGG 1PPQA 2YRAA 1QGBA 2MCYA 1HCCA 2O39C 5HYPA 1CKLA 5I0QB 4PZ5A 1HFHA 1OK3A 3M7PA 3NFPI 1ZJKA 3ERBA 2XRDA 2RKZA 3EJHA 4ONTD 2W80A 4MUCA 3IX0A 4AYIA 3T5OA 1LY2A 1E5GA 2IZ4A 1OJYA 3MQLA 2LOJA 1U5MA 2XRBA 2CG6A 1OJWA 1SRZA 5HYUB 3OXUD 3IU3I 4WJG2 1H2QP 4B2RA 2JRAA 4J38B 1OK2A 1VVDA 2UWNA 3KZJA 1E8BA 4LOSA
chains in the Genus database with same CATH superfamily
1E88A 2EC3A 5FO8C 4AYEA 3GXEA 4C16A 1C1ZA 1ELVA 2YBYA 1H04P 5HYTB 4IGDA 4AYMA 4LOTA 2XWBF 3L89M 3RJ3D 4BWCA 2JGWA 2QY0A 2EHFA 1FBRA 2B5ID 2Y8TA 2A55A 3KXVA 2CG7A 2I2LA 2BZMA 3K3TA 4YIZA 4ZH1D 2RL0A 3FGTA 1OK9A 3INBC 4B2SA 4MSLA 1MD8A 2RLPA 2MCZA 2KMSA 5HZPB 1QO6A 4APLA 2XQWC 4CSYA 1G4FA 4A5WB 1TPGA 3CI0J 2G7IA 2V8EA 3ZLDA 2RLQA 4N7EA 3ZLEA 1H03P 3OP8A 1GPZA 1Q3XA 3FGRA 2JGXA 2IZ3A 5JPMG 1MD7A 3R62A 2RKYA 3ZD1A 4K12A 1TPMA 3ZD2A 4AYDA 4F4OC 1UOTP 4DJZA 1GKNA 1H2PP 1Z92B 1HFIA 2ERJA 1QUBA 2ZYCA 3VWOA 1TPNA 2KRIA 3GOVA 1O9AA 1OJVA 3TVJA 4JHSA 1GHQB 2WIIC 1SS2A 3OEDC 1VVCA 3SW0X 3ZRZA 2W81A 1G4GA 2Y8SA 1GKGA 2CKUA 4KKDA 4YNXA 3O8EB 3CALA 2XWJI 1OK1A 1NWVA 4FXGG 1PPQA 2YRAA 1QGBA 5DN4A 2MCYA 1HCCA 2O39C 5HYPA 1CKLA 5I0QB 4PZ5A 1HFHA 1OK3A 4PO7A 1RLHA 3M7PA 3NFPI 1ZJKA 3ERBA 2XRDA 2RKZA 3EJHA 4ONTD 2W80A 4MUCA 3WSXA 3IX0A 5DN5A 4AYIA 3T5OA 1LY2A 1E5GA 2Y8RA 2IZ4A 1OJYA 3MQLA 2LOJA 1U5MA 2XRBA 2CG6A 2X2ZA 1OJWA 3F6KA 1SRZA 5HYUB 3OXUD 3IU3I 4WJG2 3NJAA 1H2QP 4B2RA 2JRAA 4J38B 1OK2A 1VVDA 2UWNA 3KZJA 1E8BA 3WSYA 4LOSA
chains in the Genus database with same CATH topology
1E88A 2EC3A 5FO8C 4AYEA 3GXEA 4C16A 1C1ZA 1ELVA 2YBYA 1H04P 5HYTB 4IGDA 4AYMA 4LOTA 2XWBF 3L89M 3RJ3D 2JGWA 2QY0A 2EHFA 1FBRA 2B5ID 3KXVA 2A55A 2CG7A 2BZMA 4ZH1D 2RL0A 1OK9A 3INBC 4B2SA 1MD8A 2RLPA 2MCZA 2KMSA 5HZPB 1QO6A 2XQWC 4CSYA 1G4FA 4A5WB 1TPGA 2G7IA 2V8EA 2RLQA 1H03P 3OP8A 1GPZA 1Q3XA 2JGXA 2IZ3A 5JPMG 1MD7A 3R62A 2RKYA 3ZD1A 4K12A 1TPMA 3ZD2A 4AYDA 4F4OC 1UOTP 4DJZA 1GKNA 1H2PP 1Z92B 1HFIA 2ERJA 1QUBA 1TPNA 2KRIA 3GOVA 1O9AA 1OJVA 3TVJA 4JHSA 1GHQB 2WIIC 1SS2A 3OEDC 1VVCA 3SW0X 3ZRZA 2W81A 1G4GA 1GKGA 2CKUA 4KKDA 4YNXA 3O8EB 3CALA 2XWJI 1OK1A 1NWVA 4FXGG 1PPQA 2YRAA 1QGBA 2MCYA 1HCCA 2O39C 5HYPA 1CKLA 5I0QB 4PZ5A 1HFHA 1OK3A 3M7PA 3NFPI 1ZJKA 3ERBA 2XRDA 2RKZA 3EJHA 4ONTD 2W80A 4MUCA 3IX0A 4AYIA 3T5OA 1LY2A 1E5GA 2IZ4A 1OJYA 3MQLA 2LOJA 1U5MA 2XRBA 2CG6A 1OJWA 1SRZA 5HYUB 3OXUD 3IU3I 4WJG2 1H2QP 4B2RA 2JRAA 4J38B 1OK2A 1VVDA 2UWNA 3KZJA 1E8BA 4LOSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1E88 A;  2EC3 A;  5FO8 C;  4AYE A;  3GXE A;  4C16 A;  1C1Z A;  1ELV A;  2YBY A;  1H04 P;  5HYT B;  4IGD A;  4AYM A;  4LOT A;  2XWB F;  3L89 M;  3RJ3 D;  2JGW A;  2QY0 A;  2EHF A;  1FBR A;  2B5I D;  3KXV A;  2A55 A;  2CG7 A;  2BZM A;  4ZH1 D;  2RL0 A;  1OK9 A;  3INB C;  4B2S A;  1MD8 A;  2RLP A;  2MCZ A;  2KMS A;  5HZP B;  1QO6 A;  2XQW C;  4CSY A;  1G4F A;  4A5W B;  1TPG A;  2G7I A;  2V8E A;  2RLQ A;  1H03 P;  3OP8 A;  1GPZ A;  1Q3X A;  2JGX A;  2IZ3 A;  5JPM G;  1MD7 A;  3R62 A;  2RKY A;  3ZD1 A;  4K12 A;  1TPM A;  3ZD2 A;  4AYD A;  4F4O C;  1UOT P;  4DJZ A;  1GKN A;  1H2P P;  1Z92 B;  1HFI A;  2ERJ A;  1QUB A;  1TPN A;  2KRI A;  3GOV A;  1O9A A;  1OJV A;  3TVJ A;  4JHS A;  1GHQ B;  2WII C;  1SS2 A;  3OED C;  1VVC A;  3SW0 X;  3ZRZ A;  2W81 A;  1G4G A;  1GKG A;  2CKU A;  4KKD A;  4YNX A;  3O8E B;  3CAL A;  2XWJ I;  1OK1 A;  1NWV A;  4FXG G;  1PPQ A;  2YRA A;  1QGB A;  2MCY A;  1HCC A;  2O39 C;  5HYP A;  1CKL A;  5I0Q B;  4PZ5 A;  1HFH A;  1OK3 A;  3M7P A;  3NFP I;  1ZJK A;  3ERB A;  2XRD A;  2RKZ A;  3EJH A;  4ONT D;  2W80 A;  4MUC A;  3IX0 A;  4AYI A;  3T5O A;  1LY2 A;  1E5G A;  2IZ4 A;  1OJY A;  3MQL A;  2LOJ A;  1U5M A;  2XRB A;  2CG6 A;  1OJW A;  1SRZ A;  5HYU B;  3OXU D;  3IU3 I;  4WJG 2;  1H2Q P;  4B2R A;  2JRA A;  4J38 B;  1OK2 A;  1VVD A;  2UWN A;  3KZJ A;  1E8B A;  4LOS A; 
#chains in the Genus database with same CATH topology
 1E88 A;  2EC3 A;  5FO8 C;  4AYE A;  3GXE A;  4C16 A;  1C1Z A;  1ELV A;  2YBY A;  1H04 P;  5HYT B;  4IGD A;  4AYM A;  4LOT A;  2XWB F;  3L89 M;  3RJ3 D;  4BWC A;  2JGW A;  2QY0 A;  2EHF A;  1FBR A;  2B5I D;  2Y8T A;  2A55 A;  3KXV A;  2CG7 A;  2I2L A;  2BZM A;  3K3T A;  4YIZ A;  4ZH1 D;  2RL0 A;  3FGT A;  1OK9 A;  3INB C;  4B2S A;  4MSL A;  1MD8 A;  2RLP A;  2MCZ A;  2KMS A;  5HZP B;  1QO6 A;  4APL A;  2XQW C;  4CSY A;  1G4F A;  4A5W B;  1TPG A;  3CI0 J;  2G7I A;  2V8E A;  3ZLD A;  2RLQ A;  4N7E A;  3ZLE A;  1H03 P;  3OP8 A;  1GPZ A;  1Q3X A;  3FGR A;  2JGX A;  2IZ3 A;  5JPM G;  1MD7 A;  3R62 A;  2RKY A;  3ZD1 A;  4K12 A;  1TPM A;  3ZD2 A;  4AYD A;  4F4O C;  1UOT P;  4DJZ A;  1GKN A;  1H2P P;  1Z92 B;  1HFI A;  2ERJ A;  1QUB A;  2ZYC A;  3VWO A;  1TPN A;  2KRI A;  3GOV A;  1O9A A;  1OJV A;  3TVJ A;  4JHS A;  1GHQ B;  2WII C;  1SS2 A;  3OED C;  1VVC A;  3SW0 X;  3ZRZ A;  2W81 A;  1G4G A;  2Y8S A;  1GKG A;  2CKU A;  4KKD A;  4YNX A;  3O8E B;  3CAL A;  2XWJ I;  1OK1 A;  1NWV A;  4FXG G;  1PPQ A;  2YRA A;  1QGB A;  5DN4 A;  2MCY A;  1HCC A;  2O39 C;  5HYP A;  1CKL A;  5I0Q B;  4PZ5 A;  1HFH A;  1OK3 A;  4PO7 A;  1RLH A;  3M7P A;  3NFP I;  1ZJK A;  3ERB A;  2XRD A;  2RKZ A;  3EJH A;  4ONT D;  2W80 A;  4MUC A;  3WSX A;  3IX0 A;  5DN5 A;  4AYI A;  3T5O A;  1LY2 A;  1E5G A;  2Y8R A;  2IZ4 A;  1OJY A;  3MQL A;  2LOJ A;  1U5M A;  2XRB A;  2CG6 A;  2X2Z A;  1OJW A;  3F6K A;  1SRZ A;  5HYU B;  3OXU D;  3IU3 I;  4WJG 2;  3NJA A;  1H2Q P;  4B2R A;  2JRA A;  4J38 B;  1OK2 A;  1VVD A;  2UWN A;  3KZJ A;  1E8B A;  3WSY A;  4LOS A; 
#chains in the Genus database with same CATH homology
 1E88 A;  2EC3 A;  5FO8 C;  4AYE A;  3GXE A;  4C16 A;  1C1Z A;  1ELV A;  2YBY A;  1H04 P;  5HYT B;  4IGD A;  4AYM A;  4LOT A;  2XWB F;  3L89 M;  3RJ3 D;  2JGW A;  2QY0 A;  2EHF A;  1FBR A;  2B5I D;  3KXV A;  2A55 A;  2CG7 A;  2BZM A;  4ZH1 D;  2RL0 A;  1OK9 A;  3INB C;  4B2S A;  1MD8 A;  2RLP A;  2MCZ A;  2KMS A;  5HZP B;  1QO6 A;  2XQW C;  4CSY A;  1G4F A;  4A5W B;  1TPG A;  2G7I A;  2V8E A;  2RLQ A;  1H03 P;  3OP8 A;  1GPZ A;  1Q3X A;  2JGX A;  2IZ3 A;  5JPM G;  1MD7 A;  3R62 A;  2RKY A;  3ZD1 A;  4K12 A;  1TPM A;  3ZD2 A;  4AYD A;  4F4O C;  1UOT P;  4DJZ A;  1GKN A;  1H2P P;  1Z92 B;  1HFI A;  2ERJ A;  1QUB A;  1TPN A;  2KRI A;  3GOV A;  1O9A A;  1OJV A;  3TVJ A;  4JHS A;  1GHQ B;  2WII C;  1SS2 A;  3OED C;  1VVC A;  3SW0 X;  3ZRZ A;  2W81 A;  1G4G A;  1GKG A;  2CKU A;  4KKD A;  4YNX A;  3O8E B;  3CAL A;  2XWJ I;  1OK1 A;  1NWV A;  4FXG G;  1PPQ A;  2YRA A;  1QGB A;  2MCY A;  1HCC A;  2O39 C;  5HYP A;  1CKL A;  5I0Q B;  4PZ5 A;  1HFH A;  1OK3 A;  3M7P A;  3NFP I;  1ZJK A;  3ERB A;  2XRD A;  2RKZ A;  3EJH A;  4ONT D;  2W80 A;  4MUC A;  3IX0 A;  4AYI A;  3T5O A;  1LY2 A;  1E5G A;  2IZ4 A;  1OJY A;  3MQL A;  2LOJ A;  1U5M A;  2XRB A;  2CG6 A;  1OJW A;  1SRZ A;  5HYU B;  3OXU D;  3IU3 I;  4WJG 2;  1H2Q P;  4B2R A;  2JRA A;  4J38 B;  1OK2 A;  1VVD A;  2UWN A;  3KZJ A;  1E8B A;  4LOS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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