2UWNA

Crystal structure of human complement factor h, scr domains 6-8 (h402 risk variant), in complex with ligand.
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
187
structure length
187
Chain Sequence
MGLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
pubmed doi rcsb
molecule keywords HUMAN COMPLEMENT FACTOR H
molecule tags Immune system
source organism Homo sapiens
total genus 37
structure length 187
sequence length 187
ec nomenclature
pdb deposition date 2007-03-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2uwnA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2uwnA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2uwnA03
2QY0A 1Q3XA 2XRBA 4YNXA 4AYDA 2IZ4A 1E5GA 2UWNA 2EHFA 1H2QP 2KMSA 1OK2A 2RLPA 2WIIC 2YRAA 1C1ZA 4ONTD 4AYEA 2JRAA 1GKGA 4B2RA 4F4OC 2RKZA 5FO8C 4FXGG 1GKNA 1MD8A 2BZMA 1TPGA 4IGDA 3ZRZA 4KKDA 2XRDA 1OJWA 3EJHA 3MQLA 3GOVA 3ERBA 1HFHA 1QO6A 2CG6A 3L89M 3O8EB 2IZ3A 2JGXA 2CG7A 1OK3A 1U5MA 1Z92B 1H03P 2RLQA 2G7IA 2B5ID 3IX0A 1NWVA 3OXUD 5JPMG 3ZD2A 3RJ3D 1FBRA 2RKYA 1GPZA 1PPQA 3ZD1A 4K12A 2LOJA 1ZJKA 3OP8A 4LOTA 2JGWA 3SW0X 4WJG2 2CKUA 1O9AA 3INBC 2W81A 5HYUB 2EC3A 3R62A 1VVDA 3KZJA 5HYTB 4AYIA 2A55A 1E8BA 2XWJI 1LY2A 5HYPA 3KXVA 4MUCA 3M7PA 2RL0A 3IU3I 4AYMA 3TVJA 1G4GA 1H04P 4C16A 4PZ5A 1E88A 5I0QB 1HCCA 4B2SA 1QUBA 3GXEA 4JHSA 4DJZA 4LOSA 2XWBF 1OJYA 2YBYA 1H2PP 2W80A 1ELVA 3OEDC 3T5OA 1CKLA 2ERJA 1UOTP 2MCYA 1G4FA 1SS2A 3NFPI 1GHQB 1MD7A 1TPMA 2KRIA 4ZH1D 4J38B 1VVCA 1HFIA 1QGBA 2V8EA 4CSYA 2XQWC 1OK1A 1OK9A 1OJVA 1TPNA 1SRZA 2O39C 2MCZA 3CALA 4A5WB 5HZPB
chains in the Genus database with same CATH superfamily
2QY0A 1Q3XA 1RLHA 2XRBA 4YNXA 4AYDA 2IZ4A 1E5GA 2UWNA 2EHFA 1H2QP 2KMSA 1OK2A 2RLPA 2WIIC 2YRAA 1C1ZA 4ONTD 4AYEA 3K3TA 5DN5A 3FGRA 4N7EA 2JRAA 1GKGA 4YIZA 4B2RA 2ZYCA 3CI0J 4F4OC 2RKZA 5FO8C 4FXGG 1GKNA 1MD8A 2BZMA 1TPGA 4IGDA 2Y8SA 3ZRZA 4KKDA 2XRDA 1OJWA 3WSXA 3EJHA 3MQLA 3GOVA 2I2LA 3ERBA 1HFHA 1QO6A 2CG6A 3L89M 3O8EB 2IZ3A 3VWOA 2JGXA 2CG7A 1OK3A 3WSYA 1U5MA 4BWCA 1Z92B 3ZLEA 1H03P 2RLQA 2G7IA 2B5ID 3IX0A 1NWVA 3OXUD 5JPMG 3ZD2A 3RJ3D 1FBRA 2RKYA 1GPZA 1PPQA 3ZD1A 4K12A 2LOJA 1ZJKA 3OP8A 4LOTA 3NJAA 2Y8TA 3ZLDA 2X2ZA 2JGWA 5DN4A 3SW0X 4WJG2 2CKUA 3F6KA 1O9AA 3INBC 2W81A 5HYUB 2EC3A 3R62A 1VVDA 3KZJA 5HYTB 4MSLA 4PO7A 4AYIA 2A55A 1E8BA 2XWJI 1LY2A 2Y8RA 5HYPA 3KXVA 3FGTA 4MUCA 3M7PA 2RL0A 3IU3I 4AYMA 3TVJA 1G4GA 1H04P 4C16A 4PZ5A 1E88A 5I0QB 1HCCA 4B2SA 1QUBA 3GXEA 4JHSA 4DJZA 4LOSA 2XWBF 1OJYA 4APLA 2YBYA 1H2PP 2W80A 1ELVA 3OEDC 3T5OA 1CKLA 2ERJA 1UOTP 2MCYA 1G4FA 1SS2A 3NFPI 1GHQB 1MD7A 1TPMA 2KRIA 4ZH1D 4J38B 1VVCA 1HFIA 1QGBA 2V8EA 4CSYA 1OK1A 1OK9A 2XQWC 1OJVA 1TPNA 1SRZA 2O39C 2MCZA 3CALA 4A5WB 5HZPB
chains in the Genus database with same CATH topology
2QY0A 1Q3XA 2XRBA 4YNXA 4AYDA 2IZ4A 1E5GA 2UWNA 2EHFA 1H2QP 2KMSA 1OK2A 2RLPA 2WIIC 2YRAA 1C1ZA 4ONTD 4AYEA 2JRAA 1GKGA 4B2RA 4F4OC 2RKZA 5FO8C 4FXGG 1GKNA 1MD8A 2BZMA 1TPGA 4IGDA 3ZRZA 4KKDA 2XRDA 1OJWA 3EJHA 3MQLA 3GOVA 3ERBA 1HFHA 1QO6A 2CG6A 3L89M 3O8EB 2IZ3A 2JGXA 2CG7A 1OK3A 1U5MA 1Z92B 1H03P 2RLQA 2G7IA 2B5ID 3IX0A 1NWVA 3OXUD 5JPMG 3ZD2A 3RJ3D 1FBRA 2RKYA 1GPZA 1PPQA 3ZD1A 4K12A 2LOJA 1ZJKA 3OP8A 4LOTA 2JGWA 3SW0X 4WJG2 2CKUA 1O9AA 3INBC 2W81A 5HYUB 2EC3A 3R62A 1VVDA 3KZJA 5HYTB 4AYIA 2A55A 1E8BA 2XWJI 1LY2A 5HYPA 3KXVA 4MUCA 3M7PA 2RL0A 3IU3I 4AYMA 3TVJA 1G4GA 1H04P 4C16A 4PZ5A 1E88A 5I0QB 1HCCA 4B2SA 1QUBA 3GXEA 4JHSA 4DJZA 4LOSA 2XWBF 1OJYA 2YBYA 1H2PP 2W80A 1ELVA 3OEDC 3T5OA 1CKLA 2ERJA 1UOTP 2MCYA 1G4FA 1SS2A 3NFPI 1GHQB 1MD7A 1TPMA 2KRIA 4ZH1D 4J38B 1VVCA 1HFIA 1QGBA 2V8EA 4CSYA 2XQWC 1OK1A 1OK9A 1OJVA 1TPNA 1SRZA 2O39C 2MCZA 3CALA 4A5WB 5HZPB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QY0 A;  1Q3X A;  2XRB A;  4YNX A;  4AYD A;  2IZ4 A;  1E5G A;  2UWN A;  2EHF A;  1H2Q P;  2KMS A;  1OK2 A;  2RLP A;  2WII C;  2YRA A;  1C1Z A;  4ONT D;  4AYE A;  2JRA A;  1GKG A;  4B2R A;  4F4O C;  2RKZ A;  5FO8 C;  4FXG G;  1GKN A;  1MD8 A;  2BZM A;  1TPG A;  4IGD A;  3ZRZ A;  4KKD A;  2XRD A;  1OJW A;  3EJH A;  3MQL A;  3GOV A;  3ERB A;  1HFH A;  1QO6 A;  2CG6 A;  3L89 M;  3O8E B;  2IZ3 A;  2JGX A;  2CG7 A;  1OK3 A;  1U5M A;  1Z92 B;  1H03 P;  2RLQ A;  2G7I A;  2B5I D;  3IX0 A;  1NWV A;  3OXU D;  5JPM G;  3ZD2 A;  3RJ3 D;  1FBR A;  2RKY A;  1GPZ A;  1PPQ A;  3ZD1 A;  4K12 A;  2LOJ A;  1ZJK A;  3OP8 A;  4LOT A;  2JGW A;  3SW0 X;  4WJG 2;  2CKU A;  1O9A A;  3INB C;  2W81 A;  5HYU B;  2EC3 A;  3R62 A;  1VVD A;  3KZJ A;  5HYT B;  4AYI A;  2A55 A;  1E8B A;  2XWJ I;  1LY2 A;  5HYP A;  3KXV A;  4MUC A;  3M7P A;  2RL0 A;  3IU3 I;  4AYM A;  3TVJ A;  1G4G A;  1H04 P;  4C16 A;  4PZ5 A;  1E88 A;  5I0Q B;  1HCC A;  4B2S A;  1QUB A;  3GXE A;  4JHS A;  4DJZ A;  4LOS A;  2XWB F;  1OJY A;  2YBY A;  1H2P P;  2W80 A;  1ELV A;  3OED C;  3T5O A;  1CKL A;  2ERJ A;  1UOT P;  2MCY A;  1G4F A;  1SS2 A;  3NFP I;  1GHQ B;  1MD7 A;  1TPM A;  2KRI A;  4ZH1 D;  4J38 B;  1VVC A;  1HFI A;  1QGB A;  2V8E A;  4CSY A;  2XQW C;  1OK1 A;  1OK9 A;  1OJV A;  1TPN A;  1SRZ A;  2O39 C;  2MCZ A;  3CAL A;  4A5W B;  5HZP B; 
#chains in the Genus database with same CATH topology
 2QY0 A;  1Q3X A;  1RLH A;  2XRB A;  4YNX A;  4AYD A;  2IZ4 A;  1E5G A;  2UWN A;  2EHF A;  1H2Q P;  2KMS A;  1OK2 A;  2RLP A;  2WII C;  2YRA A;  1C1Z A;  4ONT D;  4AYE A;  3K3T A;  5DN5 A;  3FGR A;  4N7E A;  2JRA A;  1GKG A;  4YIZ A;  4B2R A;  2ZYC A;  3CI0 J;  4F4O C;  2RKZ A;  5FO8 C;  4FXG G;  1GKN A;  1MD8 A;  2BZM A;  1TPG A;  4IGD A;  2Y8S A;  3ZRZ A;  4KKD A;  2XRD A;  1OJW A;  3WSX A;  3EJH A;  3MQL A;  3GOV A;  2I2L A;  3ERB A;  1HFH A;  1QO6 A;  2CG6 A;  3L89 M;  3O8E B;  2IZ3 A;  3VWO A;  2JGX A;  2CG7 A;  1OK3 A;  3WSY A;  1U5M A;  4BWC A;  1Z92 B;  3ZLE A;  1H03 P;  2RLQ A;  2G7I A;  2B5I D;  3IX0 A;  1NWV A;  3OXU D;  5JPM G;  3ZD2 A;  3RJ3 D;  1FBR A;  2RKY A;  1GPZ A;  1PPQ A;  3ZD1 A;  4K12 A;  2LOJ A;  1ZJK A;  3OP8 A;  4LOT A;  3NJA A;  2Y8T A;  3ZLD A;  2X2Z A;  2JGW A;  5DN4 A;  3SW0 X;  4WJG 2;  2CKU A;  3F6K A;  1O9A A;  3INB C;  2W81 A;  5HYU B;  2EC3 A;  3R62 A;  1VVD A;  3KZJ A;  5HYT B;  4MSL A;  4PO7 A;  4AYI A;  2A55 A;  1E8B A;  2XWJ I;  1LY2 A;  2Y8R A;  5HYP A;  3KXV A;  3FGT A;  4MUC A;  3M7P A;  2RL0 A;  3IU3 I;  4AYM A;  3TVJ A;  1G4G A;  1H04 P;  4C16 A;  4PZ5 A;  1E88 A;  5I0Q B;  1HCC A;  4B2S A;  1QUB A;  3GXE A;  4JHS A;  4DJZ A;  4LOS A;  2XWB F;  1OJY A;  4APL A;  2YBY A;  1H2P P;  2W80 A;  1ELV A;  3OED C;  3T5O A;  1CKL A;  2ERJ A;  1UOT P;  2MCY A;  1G4F A;  1SS2 A;  3NFP I;  1GHQ B;  1MD7 A;  1TPM A;  2KRI A;  4ZH1 D;  4J38 B;  1VVC A;  1HFI A;  1QGB A;  2V8E A;  4CSY A;  1OK1 A;  1OK9 A;  2XQW C;  1OJV A;  1TPN A;  1SRZ A;  2O39 C;  2MCZ A;  3CAL A;  4A5W B;  5HZP B; 
#chains in the Genus database with same CATH homology
 2QY0 A;  1Q3X A;  2XRB A;  4YNX A;  4AYD A;  2IZ4 A;  1E5G A;  2UWN A;  2EHF A;  1H2Q P;  2KMS A;  1OK2 A;  2RLP A;  2WII C;  2YRA A;  1C1Z A;  4ONT D;  4AYE A;  2JRA A;  1GKG A;  4B2R A;  4F4O C;  2RKZ A;  5FO8 C;  4FXG G;  1GKN A;  1MD8 A;  2BZM A;  1TPG A;  4IGD A;  3ZRZ A;  4KKD A;  2XRD A;  1OJW A;  3EJH A;  3MQL A;  3GOV A;  3ERB A;  1HFH A;  1QO6 A;  2CG6 A;  3L89 M;  3O8E B;  2IZ3 A;  2JGX A;  2CG7 A;  1OK3 A;  1U5M A;  1Z92 B;  1H03 P;  2RLQ A;  2G7I A;  2B5I D;  3IX0 A;  1NWV A;  3OXU D;  5JPM G;  3ZD2 A;  3RJ3 D;  1FBR A;  2RKY A;  1GPZ A;  1PPQ A;  3ZD1 A;  4K12 A;  2LOJ A;  1ZJK A;  3OP8 A;  4LOT A;  2JGW A;  3SW0 X;  4WJG 2;  2CKU A;  1O9A A;  3INB C;  2W81 A;  5HYU B;  2EC3 A;  3R62 A;  1VVD A;  3KZJ A;  5HYT B;  4AYI A;  2A55 A;  1E8B A;  2XWJ I;  1LY2 A;  5HYP A;  3KXV A;  4MUC A;  3M7P A;  2RL0 A;  3IU3 I;  4AYM A;  3TVJ A;  1G4G A;  1H04 P;  4C16 A;  4PZ5 A;  1E88 A;  5I0Q B;  1HCC A;  4B2S A;  1QUB A;  3GXE A;  4JHS A;  4DJZ A;  4LOS A;  2XWB F;  1OJY A;  2YBY A;  1H2P P;  2W80 A;  1ELV A;  3OED C;  3T5O A;  1CKL A;  2ERJ A;  1UOT P;  2MCY A;  1G4F A;  1SS2 A;  3NFP I;  1GHQ B;  1MD7 A;  1TPM A;  2KRI A;  4ZH1 D;  4J38 B;  1VVC A;  1HFI A;  1QGB A;  2V8E A;  4CSY A;  2XQW C;  1OK1 A;  1OK9 A;  1OJV A;  1TPN A;  1SRZ A;  2O39 C;  2MCZ A;  3CAL A;  4A5W B;  5HZP B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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