2V8EA

Crystal structure of human complement factor h, scr domains 6-8 (h402 risk variant), in complex with ligand.
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
187
structure length
187
Chain Sequence
MGLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
pubmed doi rcsb
molecule keywords COMPLEMENT FACTOR H
molecule tags Immune system
source organism Homo sapiens
total genus 34
structure length 187
sequence length 187
ec nomenclature
pdb deposition date 2007-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA03
4YNXA 3MQLA 1OJVA 1UOTP 1QO6A 1LY2A 2RLQA 1GKGA 1NWVA 3KXVA 4B2SA 1H2PP 4DJZA 1MD7A 1HFIA 1TPMA 4IGDA 5I0QB 5JPMG 3TVJA 1CKLA 2BZMA 2XRDA 4ONTD 4AYMA 3OEDC 1VVDA 2UWNA 2JGWA 1G4FA 4C16A 2B5ID 1ZJKA 1GKNA 2A55A 2KRIA 4B2RA 2QY0A 1OK1A 1ELVA 1GPZA 3IX0A 3ZD2A 2YBYA 4FXGG 3ZRZA 3CALA 1HFHA 3INBC 2ERJA 5HZPB 2JGXA 2O39C 3IU3I 4J38B 2RKZA 1O9AA 4MUCA 1E8BA 2XQWC 1G4GA 3R62A 4AYDA 4WJG2 5HYTB 1HCCA 4A5WB 2RL0A 4ZH1D 1C1ZA 2W80A 3SW0X 3KZJA 2G7IA 3GOVA 1TPNA 1Z92B 1FBRA 2IZ4A 1OJWA 2EC3A 2IZ3A 3GXEA 4K12A 2EHFA 2JRAA 2XRBA 3O8EB 1QUBA 1TPGA 3OXUD 1H04P 3ERBA 5HYUB 1U5MA 2CG6A 1PPQA 4CSYA 1MD8A 2V8EA 4JHSA 1VVCA 3L89M 1OJYA 1Q3XA 1SS2A 2RLPA 1SRZA 2LOJA 1E88A 1QGBA 1OK3A 3EJHA 4LOTA 1OK9A 3ZD1A 2KMSA 2CG7A 3RJ3D 2MCYA 4KKDA 3M7PA 5HYPA 2XWBF 2CKUA 4AYEA 1H2QP 4PZ5A 2W81A 4LOSA 1H03P 1OK2A 1GHQB 2RKYA 2XWJI 4F4OC 3OP8A 2YRAA 5FO8C 2WIIC 4AYIA 3NFPI 1E5GA 2MCZA 3T5OA
chains in the Genus database with same CATH superfamily
4YNXA 3MQLA 1OJVA 1UOTP 1QO6A 1LY2A 2RLQA 1GKGA 1NWVA 3KXVA 4B2SA 1H2PP 3FGTA 4DJZA 1MD7A 1HFIA 1TPMA 4IGDA 5I0QB 5JPMG 3TVJA 1CKLA 2BZMA 2XRDA 4ONTD 4AYMA 3OEDC 1VVDA 2UWNA 2JGWA 1G4FA 4YIZA 4C16A 2B5ID 1ZJKA 1GKNA 2A55A 2KRIA 4B2RA 2QY0A 1OK1A 1ELVA 1GPZA 3IX0A 3ZD2A 2YBYA 4FXGG 3ZRZA 3CALA 1HFHA 3FGRA 3INBC 2ERJA 5HZPB 2JGXA 2O39C 3IU3I 4MSLA 4J38B 2RKZA 1O9AA 4MUCA 1E8BA 2XQWC 1G4GA 4PO7A 3R62A 1RLHA 4AYDA 4WJG2 3VWOA 5HYTB 1HCCA 4A5WB 3F6KA 2RL0A 4ZH1D 1C1ZA 2W80A 3SW0X 3KZJA 2G7IA 3GOVA 5DN4A 1TPNA 1Z92B 3CI0J 1FBRA 2IZ4A 4N7EA 1OJWA 2EC3A 2IZ3A 3GXEA 4K12A 2EHFA 2JRAA 3WSXA 3K3TA 2XRBA 3O8EB 1QUBA 1TPGA 2Y8RA 1H04P 3ERBA 3OXUD 5HYUB 2X2ZA 1U5MA 2CG6A 1PPQA 4CSYA 1MD8A 2V8EA 4JHSA 1VVCA 3ZLEA 3L89M 1OJYA 1Q3XA 3NJAA 1SS2A 2RLPA 1SRZA 3ZLDA 2LOJA 1E88A 1QGBA 2Y8TA 3WSYA 1OK3A 3EJHA 4LOTA 2ZYCA 1OK9A 3ZD1A 5DN5A 2KMSA 2CG7A 2Y8SA 3RJ3D 2MCYA 4KKDA 3M7PA 5HYPA 2XWBF 2CKUA 4AYEA 1H2QP 4PZ5A 2W81A 4LOSA 4BWCA 2I2LA 1H03P 1OK2A 1GHQB 2RKYA 2XWJI 4F4OC 3OP8A 2YRAA 5FO8C 2WIIC 4AYIA 3NFPI 4APLA 1E5GA 2MCZA 3T5OA
chains in the Genus database with same CATH topology
4YNXA 3MQLA 1OJVA 1UOTP 1QO6A 1LY2A 2RLQA 1GKGA 1NWVA 3KXVA 4B2SA 1H2PP 4DJZA 1MD7A 1HFIA 1TPMA 4IGDA 5I0QB 5JPMG 3TVJA 1CKLA 2BZMA 2XRDA 4ONTD 4AYMA 3OEDC 1VVDA 2UWNA 2JGWA 1G4FA 4C16A 2B5ID 1ZJKA 1GKNA 2A55A 2KRIA 4B2RA 2QY0A 1OK1A 1ELVA 1GPZA 3IX0A 3ZD2A 2YBYA 4FXGG 3ZRZA 3CALA 1HFHA 3INBC 2ERJA 5HZPB 2JGXA 2O39C 3IU3I 4J38B 2RKZA 1O9AA 4MUCA 1E8BA 2XQWC 1G4GA 3R62A 4AYDA 4WJG2 5HYTB 1HCCA 4A5WB 2RL0A 4ZH1D 1C1ZA 2W80A 3SW0X 3KZJA 2G7IA 3GOVA 1TPNA 1Z92B 1FBRA 2IZ4A 1OJWA 2EC3A 2IZ3A 3GXEA 4K12A 2EHFA 2JRAA 2XRBA 3O8EB 1QUBA 1TPGA 3OXUD 1H04P 3ERBA 5HYUB 1U5MA 2CG6A 1PPQA 4CSYA 1MD8A 2V8EA 4JHSA 1VVCA 3L89M 1OJYA 1Q3XA 1SS2A 2RLPA 1SRZA 2LOJA 1E88A 1QGBA 1OK3A 3EJHA 4LOTA 1OK9A 3ZD1A 2KMSA 2CG7A 3RJ3D 2MCYA 4KKDA 3M7PA 5HYPA 2XWBF 2CKUA 4AYEA 1H2QP 4PZ5A 2W81A 4LOSA 1H03P 1OK2A 1GHQB 2RKYA 2XWJI 4F4OC 3OP8A 2YRAA 5FO8C 2WIIC 4AYIA 3NFPI 1E5GA 2MCZA 3T5OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YNX A;  3MQL A;  1OJV A;  1UOT P;  1QO6 A;  1LY2 A;  2RLQ A;  1GKG A;  1NWV A;  3KXV A;  4B2S A;  1H2P P;  4DJZ A;  1MD7 A;  1HFI A;  1TPM A;  4IGD A;  5I0Q B;  5JPM G;  3TVJ A;  1CKL A;  2BZM A;  2XRD A;  4ONT D;  4AYM A;  3OED C;  1VVD A;  2UWN A;  2JGW A;  1G4F A;  4C16 A;  2B5I D;  1ZJK A;  1GKN A;  2A55 A;  2KRI A;  4B2R A;  2QY0 A;  1OK1 A;  1ELV A;  1GPZ A;  3IX0 A;  3ZD2 A;  2YBY A;  4FXG G;  3ZRZ A;  3CAL A;  1HFH A;  3INB C;  2ERJ A;  5HZP B;  2JGX A;  2O39 C;  3IU3 I;  4J38 B;  2RKZ A;  1O9A A;  4MUC A;  1E8B A;  2XQW C;  1G4G A;  3R62 A;  4AYD A;  4WJG 2;  5HYT B;  1HCC A;  4A5W B;  2RL0 A;  4ZH1 D;  1C1Z A;  2W80 A;  3SW0 X;  3KZJ A;  2G7I A;  3GOV A;  1TPN A;  1Z92 B;  1FBR A;  2IZ4 A;  1OJW A;  2EC3 A;  2IZ3 A;  3GXE A;  4K12 A;  2EHF A;  2JRA A;  2XRB A;  3O8E B;  1QUB A;  1TPG A;  3OXU D;  1H04 P;  3ERB A;  5HYU B;  1U5M A;  2CG6 A;  1PPQ A;  4CSY A;  1MD8 A;  2V8E A;  4JHS A;  1VVC A;  3L89 M;  1OJY A;  1Q3X A;  1SS2 A;  2RLP A;  1SRZ A;  2LOJ A;  1E88 A;  1QGB A;  1OK3 A;  3EJH A;  4LOT A;  1OK9 A;  3ZD1 A;  2KMS A;  2CG7 A;  3RJ3 D;  2MCY A;  4KKD A;  3M7P A;  5HYP A;  2XWB F;  2CKU A;  4AYE A;  1H2Q P;  4PZ5 A;  2W81 A;  4LOS A;  1H03 P;  1OK2 A;  1GHQ B;  2RKY A;  2XWJ I;  4F4O C;  3OP8 A;  2YRA A;  5FO8 C;  2WII C;  4AYI A;  3NFP I;  1E5G A;  2MCZ A;  3T5O A; 
#chains in the Genus database with same CATH topology
 4YNX A;  3MQL A;  1OJV A;  1UOT P;  1QO6 A;  1LY2 A;  2RLQ A;  1GKG A;  1NWV A;  3KXV A;  4B2S A;  1H2P P;  3FGT A;  4DJZ A;  1MD7 A;  1HFI A;  1TPM A;  4IGD A;  5I0Q B;  5JPM G;  3TVJ A;  1CKL A;  2BZM A;  2XRD A;  4ONT D;  4AYM A;  3OED C;  1VVD A;  2UWN A;  2JGW A;  1G4F A;  4YIZ A;  4C16 A;  2B5I D;  1ZJK A;  1GKN A;  2A55 A;  2KRI A;  4B2R A;  2QY0 A;  1OK1 A;  1ELV A;  1GPZ A;  3IX0 A;  3ZD2 A;  2YBY A;  4FXG G;  3ZRZ A;  3CAL A;  1HFH A;  3FGR A;  3INB C;  2ERJ A;  5HZP B;  2JGX A;  2O39 C;  3IU3 I;  4MSL A;  4J38 B;  2RKZ A;  1O9A A;  4MUC A;  1E8B A;  2XQW C;  1G4G A;  4PO7 A;  3R62 A;  1RLH A;  4AYD A;  4WJG 2;  3VWO A;  5HYT B;  1HCC A;  4A5W B;  3F6K A;  2RL0 A;  4ZH1 D;  1C1Z A;  2W80 A;  3SW0 X;  3KZJ A;  2G7I A;  3GOV A;  5DN4 A;  1TPN A;  1Z92 B;  3CI0 J;  1FBR A;  2IZ4 A;  4N7E A;  1OJW A;  2EC3 A;  2IZ3 A;  3GXE A;  4K12 A;  2EHF A;  2JRA A;  3WSX A;  3K3T A;  2XRB A;  3O8E B;  1QUB A;  1TPG A;  2Y8R A;  1H04 P;  3ERB A;  3OXU D;  5HYU B;  2X2Z A;  1U5M A;  2CG6 A;  1PPQ A;  4CSY A;  1MD8 A;  2V8E A;  4JHS A;  1VVC A;  3ZLE A;  3L89 M;  1OJY A;  1Q3X A;  3NJA A;  1SS2 A;  2RLP A;  1SRZ A;  3ZLD A;  2LOJ A;  1E88 A;  1QGB A;  2Y8T A;  3WSY A;  1OK3 A;  3EJH A;  4LOT A;  2ZYC A;  1OK9 A;  3ZD1 A;  5DN5 A;  2KMS A;  2CG7 A;  2Y8S A;  3RJ3 D;  2MCY A;  4KKD A;  3M7P A;  5HYP A;  2XWB F;  2CKU A;  4AYE A;  1H2Q P;  4PZ5 A;  2W81 A;  4LOS A;  4BWC A;  2I2L A;  1H03 P;  1OK2 A;  1GHQ B;  2RKY A;  2XWJ I;  4F4O C;  3OP8 A;  2YRA A;  5FO8 C;  2WII C;  4AYI A;  3NFP I;  4APL A;  1E5G A;  2MCZ A;  3T5O A; 
#chains in the Genus database with same CATH homology
 4YNX A;  3MQL A;  1OJV A;  1UOT P;  1QO6 A;  1LY2 A;  2RLQ A;  1GKG A;  1NWV A;  3KXV A;  4B2S A;  1H2P P;  4DJZ A;  1MD7 A;  1HFI A;  1TPM A;  4IGD A;  5I0Q B;  5JPM G;  3TVJ A;  1CKL A;  2BZM A;  2XRD A;  4ONT D;  4AYM A;  3OED C;  1VVD A;  2UWN A;  2JGW A;  1G4F A;  4C16 A;  2B5I D;  1ZJK A;  1GKN A;  2A55 A;  2KRI A;  4B2R A;  2QY0 A;  1OK1 A;  1ELV A;  1GPZ A;  3IX0 A;  3ZD2 A;  2YBY A;  4FXG G;  3ZRZ A;  3CAL A;  1HFH A;  3INB C;  2ERJ A;  5HZP B;  2JGX A;  2O39 C;  3IU3 I;  4J38 B;  2RKZ A;  1O9A A;  4MUC A;  1E8B A;  2XQW C;  1G4G A;  3R62 A;  4AYD A;  4WJG 2;  5HYT B;  1HCC A;  4A5W B;  2RL0 A;  4ZH1 D;  1C1Z A;  2W80 A;  3SW0 X;  3KZJ A;  2G7I A;  3GOV A;  1TPN A;  1Z92 B;  1FBR A;  2IZ4 A;  1OJW A;  2EC3 A;  2IZ3 A;  3GXE A;  4K12 A;  2EHF A;  2JRA A;  2XRB A;  3O8E B;  1QUB A;  1TPG A;  3OXU D;  1H04 P;  3ERB A;  5HYU B;  1U5M A;  2CG6 A;  1PPQ A;  4CSY A;  1MD8 A;  2V8E A;  4JHS A;  1VVC A;  3L89 M;  1OJY A;  1Q3X A;  1SS2 A;  2RLP A;  1SRZ A;  2LOJ A;  1E88 A;  1QGB A;  1OK3 A;  3EJH A;  4LOT A;  1OK9 A;  3ZD1 A;  2KMS A;  2CG7 A;  3RJ3 D;  2MCY A;  4KKD A;  3M7P A;  5HYP A;  2XWB F;  2CKU A;  4AYE A;  1H2Q P;  4PZ5 A;  2W81 A;  4LOS A;  1H03 P;  1OK2 A;  1GHQ B;  2RKY A;  2XWJ I;  4F4O C;  3OP8 A;  2YRA A;  5FO8 C;  2WII C;  4AYI A;  3NFP I;  1E5G A;  2MCZ A;  3T5O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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