2V8EA

Crystal structure of human complement factor h, scr domains 6-8 (h402 risk variant), in complex with ligand.
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
187
structure length
187
Chain Sequence
MGLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune system
source organism Homo sapiens
publication title Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
pubmed doi rcsb
molecule keywords COMPLEMENT FACTOR H
total genus 34
structure length 187
sequence length 187
ec nomenclature
pdb deposition date 2007-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2v8eA03
3L89M 4B2RA 1E8BA 2XWBF 2XRDA 4MUCA 1O9AA 2CG6A 4FXGG 2RL0A 3T5OA 2IZ4A 2KRIA 5HZPB 1TPMA 3MQLA 1OJYA 4K12A 1MD8A 2XRBA 1HFHA 2W81A 1E5GA 4ZH1D 2YRAA 1TPNA 2EC3A 4A5WB 3EJHA 1GKGA 1Z92B 4JHSA 1TPGA 2WIIC 1H04P 1U5MA 2BZMA 3ERBA 1E88A 1GHQB 2MCZA 5HYPA 1OK2A 2JRAA 4CSYA 4J38B 1ELVA 5HYUB 2CG7A 1UOTP 3CALA 1HFIA 2IZ3A 5JPMG 2QY0A 3IX0A 1Q3XA 2KMSA 1SS2A 3SW0X 1VVCA 3INBC 1QO6A 2EHFA 1MD7A 2RLPA 1CKLA 2XQWC 1OK9A 2RKZA 2CKUA 1VVDA 1HCCA 4IGDA 4LOTA 2B5ID 2A55A 3O8EB 3R62A 3OXUD 1H03P 1C1ZA 1PPQA 4WJG2 1G4GA 1FBRA 1LY2A 4DJZA 2RLQA 1OJVA 4B2SA 2YBYA 3IU3I 3OEDC 4YNXA 4C16A 1ZJKA 2RKYA 2V8EA 2O39C 3GOVA 1GKNA 4AYEA 2MCYA 3ZD1A 3KZJA 3M7PA 1SRZA 5FO8C 3RJ3D 3TVJA 2LOJA 4KKDA 2G7IA 1QUBA 5I0QB 2ERJA 3GXEA 2XWJI 4LOSA 3KXVA 3ZD2A 4AYMA 1OK3A 1OJWA 2JGWA 4AYIA 1H2QP 1G4FA 1OK1A 1QGBA 3OP8A 4AYDA 2JGXA 4ONTD 1H2PP 5HYTB 1GPZA 3NFPI 1NWVA 3ZRZA 2UWNA 4PZ5A 4F4OC 2W80A
chains in the Genus database with same CATH superfamily
3L89M 4B2RA 4BWCA 1E8BA 2XWBF 2XRDA 4MUCA 1O9AA 2CG6A 4FXGG 2RL0A 3T5OA 2IZ4A 2KRIA 5HZPB 2Y8RA 1TPMA 3MQLA 1OJYA 4K12A 1MD8A 2XRBA 1HFHA 2W81A 3F6KA 4MSLA 4ZH1D 1E5GA 2YRAA 1TPNA 2EC3A 4A5WB 3FGTA 4PO7A 3EJHA 3ZLEA 1GKGA 1Z92B 4JHSA 1TPGA 2WIIC 3NJAA 1H04P 1U5MA 2BZMA 3ERBA 1E88A 1GHQB 2MCZA 5HYPA 1OK2A 2JRAA 4CSYA 4J38B 1ELVA 5HYUB 2CG7A 1UOTP 3CALA 1HFIA 2IZ3A 5JPMG 2QY0A 3IX0A 4YIZA 1Q3XA 2KMSA 1SS2A 2Y8SA 3SW0X 1VVCA 3CI0J 3INBC 1QO6A 2EHFA 1MD7A 2RLPA 1CKLA 1RLHA 2XQWC 1OK9A 2RKZA 2CKUA 1VVDA 1HCCA 4IGDA 4LOTA 2B5ID 2A55A 3O8EB 3R62A 3OXUD 1H03P 1C1ZA 1PPQA 4WJG2 1G4GA 1FBRA 3ZLDA 1LY2A 4DJZA 2RLQA 1OJVA 4B2SA 2YBYA 3WSXA 3IU3I 3OEDC 4YNXA 4C16A 1ZJKA 2X2ZA 2RKYA 2V8EA 2O39C 3GOVA 1GKNA 4APLA 4AYEA 2MCYA 3ZD1A 3KZJA 3M7PA 1SRZA 5FO8C 3RJ3D 3TVJA 2LOJA 2I2LA 4KKDA 3FGRA 2G7IA 1QUBA 5I0QB 2ERJA 3GXEA 2XWJI 4LOSA 3KXVA 3ZD2A 4AYMA 1OK3A 1OJWA 2JGWA 4AYIA 1H2QP 3VWOA 1G4FA 1OK1A 4N7EA 1QGBA 3WSYA 3OP8A 2ZYCA 3K3TA 4AYDA 2JGXA 4ONTD 5DN5A 1H2PP 5HYTB 1GPZA 3NFPI 1NWVA 5DN4A 3ZRZA 2UWNA 2Y8TA 4PZ5A 4F4OC 2W80A
chains in the Genus database with same CATH topology
3L89M 4B2RA 1E8BA 2XWBF 2XRDA 4MUCA 1O9AA 2CG6A 4FXGG 2RL0A 3T5OA 2IZ4A 2KRIA 5HZPB 1TPMA 3MQLA 1OJYA 4K12A 1MD8A 2XRBA 1HFHA 2W81A 1E5GA 4ZH1D 2YRAA 1TPNA 2EC3A 4A5WB 3EJHA 1GKGA 1Z92B 4JHSA 1TPGA 2WIIC 1H04P 1U5MA 2BZMA 3ERBA 1E88A 1GHQB 2MCZA 5HYPA 1OK2A 2JRAA 4CSYA 4J38B 1ELVA 5HYUB 2CG7A 1UOTP 3CALA 1HFIA 2IZ3A 5JPMG 2QY0A 3IX0A 1Q3XA 2KMSA 1SS2A 3SW0X 1VVCA 3INBC 1QO6A 2EHFA 1MD7A 2RLPA 1CKLA 2XQWC 1OK9A 2RKZA 2CKUA 1VVDA 1HCCA 4IGDA 4LOTA 2B5ID 2A55A 3O8EB 3R62A 3OXUD 1H03P 1C1ZA 1PPQA 4WJG2 1G4GA 1FBRA 1LY2A 4DJZA 2RLQA 1OJVA 4B2SA 2YBYA 3IU3I 3OEDC 4YNXA 4C16A 1ZJKA 2RKYA 2V8EA 2O39C 3GOVA 1GKNA 4AYEA 2MCYA 3ZD1A 3KZJA 3M7PA 1SRZA 5FO8C 3RJ3D 3TVJA 2LOJA 4KKDA 2G7IA 1QUBA 5I0QB 2ERJA 3GXEA 2XWJI 4LOSA 3KXVA 3ZD2A 4AYMA 1OK3A 1OJWA 2JGWA 4AYIA 1H2QP 1G4FA 1OK1A 1QGBA 3OP8A 4AYDA 2JGXA 4ONTD 1H2PP 5HYTB 1GPZA 3NFPI 1NWVA 3ZRZA 2UWNA 4PZ5A 4F4OC 2W80A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3L89 M;  4B2R A;  1E8B A;  2XWB F;  2XRD A;  4MUC A;  1O9A A;  2CG6 A;  4FXG G;  2RL0 A;  3T5O A;  2IZ4 A;  2KRI A;  5HZP B;  1TPM A;  3MQL A;  1OJY A;  4K12 A;  1MD8 A;  2XRB A;  1HFH A;  2W81 A;  1E5G A;  4ZH1 D;  2YRA A;  1TPN A;  2EC3 A;  4A5W B;  3EJH A;  1GKG A;  1Z92 B;  4JHS A;  1TPG A;  2WII C;  1H04 P;  1U5M A;  2BZM A;  3ERB A;  1E88 A;  1GHQ B;  2MCZ A;  5HYP A;  1OK2 A;  2JRA A;  4CSY A;  4J38 B;  1ELV A;  5HYU B;  2CG7 A;  1UOT P;  3CAL A;  1HFI A;  2IZ3 A;  5JPM G;  2QY0 A;  3IX0 A;  1Q3X A;  2KMS A;  1SS2 A;  3SW0 X;  1VVC A;  3INB C;  1QO6 A;  2EHF A;  1MD7 A;  2RLP A;  1CKL A;  2XQW C;  1OK9 A;  2RKZ A;  2CKU A;  1VVD A;  1HCC A;  4IGD A;  4LOT A;  2B5I D;  2A55 A;  3O8E B;  3R62 A;  3OXU D;  1H03 P;  1C1Z A;  1PPQ A;  4WJG 2;  1G4G A;  1FBR A;  1LY2 A;  4DJZ A;  2RLQ A;  1OJV A;  4B2S A;  2YBY A;  3IU3 I;  3OED C;  4YNX A;  4C16 A;  1ZJK A;  2RKY A;  2V8E A;  2O39 C;  3GOV A;  1GKN A;  4AYE A;  2MCY A;  3ZD1 A;  3KZJ A;  3M7P A;  1SRZ A;  5FO8 C;  3RJ3 D;  3TVJ A;  2LOJ A;  4KKD A;  2G7I A;  1QUB A;  5I0Q B;  2ERJ A;  3GXE A;  2XWJ I;  4LOS A;  3KXV A;  3ZD2 A;  4AYM A;  1OK3 A;  1OJW A;  2JGW A;  4AYI A;  1H2Q P;  1G4F A;  1OK1 A;  1QGB A;  3OP8 A;  4AYD A;  2JGX A;  4ONT D;  1H2P P;  5HYT B;  1GPZ A;  3NFP I;  1NWV A;  3ZRZ A;  2UWN A;  4PZ5 A;  4F4O C;  2W80 A; 
#chains in the Genus database with same CATH topology
 3L89 M;  4B2R A;  4BWC A;  1E8B A;  2XWB F;  2XRD A;  4MUC A;  1O9A A;  2CG6 A;  4FXG G;  2RL0 A;  3T5O A;  2IZ4 A;  2KRI A;  5HZP B;  2Y8R A;  1TPM A;  3MQL A;  1OJY A;  4K12 A;  1MD8 A;  2XRB A;  1HFH A;  2W81 A;  3F6K A;  4MSL A;  4ZH1 D;  1E5G A;  2YRA A;  1TPN A;  2EC3 A;  4A5W B;  3FGT A;  4PO7 A;  3EJH A;  3ZLE A;  1GKG A;  1Z92 B;  4JHS A;  1TPG A;  2WII C;  3NJA A;  1H04 P;  1U5M A;  2BZM A;  3ERB A;  1E88 A;  1GHQ B;  2MCZ A;  5HYP A;  1OK2 A;  2JRA A;  4CSY A;  4J38 B;  1ELV A;  5HYU B;  2CG7 A;  1UOT P;  3CAL A;  1HFI A;  2IZ3 A;  5JPM G;  2QY0 A;  3IX0 A;  4YIZ A;  1Q3X A;  2KMS A;  1SS2 A;  2Y8S A;  3SW0 X;  1VVC A;  3CI0 J;  3INB C;  1QO6 A;  2EHF A;  1MD7 A;  2RLP A;  1CKL A;  1RLH A;  2XQW C;  1OK9 A;  2RKZ A;  2CKU A;  1VVD A;  1HCC A;  4IGD A;  4LOT A;  2B5I D;  2A55 A;  3O8E B;  3R62 A;  3OXU D;  1H03 P;  1C1Z A;  1PPQ A;  4WJG 2;  1G4G A;  1FBR A;  3ZLD A;  1LY2 A;  4DJZ A;  2RLQ A;  1OJV A;  4B2S A;  2YBY A;  3WSX A;  3IU3 I;  3OED C;  4YNX A;  4C16 A;  1ZJK A;  2X2Z A;  2RKY A;  2V8E A;  2O39 C;  3GOV A;  1GKN A;  4APL A;  4AYE A;  2MCY A;  3ZD1 A;  3KZJ A;  3M7P A;  1SRZ A;  5FO8 C;  3RJ3 D;  3TVJ A;  2LOJ A;  2I2L A;  4KKD A;  3FGR A;  2G7I A;  1QUB A;  5I0Q B;  2ERJ A;  3GXE A;  2XWJ I;  4LOS A;  3KXV A;  3ZD2 A;  4AYM A;  1OK3 A;  1OJW A;  2JGW A;  4AYI A;  1H2Q P;  3VWO A;  1G4F A;  1OK1 A;  4N7E A;  1QGB A;  3WSY A;  3OP8 A;  2ZYC A;  3K3T A;  4AYD A;  2JGX A;  4ONT D;  5DN5 A;  1H2P P;  5HYT B;  1GPZ A;  3NFP I;  1NWV A;  5DN4 A;  3ZRZ A;  2UWN A;  2Y8T A;  4PZ5 A;  4F4O C;  2W80 A; 
#chains in the Genus database with same CATH homology
 3L89 M;  4B2R A;  1E8B A;  2XWB F;  2XRD A;  4MUC A;  1O9A A;  2CG6 A;  4FXG G;  2RL0 A;  3T5O A;  2IZ4 A;  2KRI A;  5HZP B;  1TPM A;  3MQL A;  1OJY A;  4K12 A;  1MD8 A;  2XRB A;  1HFH A;  2W81 A;  1E5G A;  4ZH1 D;  2YRA A;  1TPN A;  2EC3 A;  4A5W B;  3EJH A;  1GKG A;  1Z92 B;  4JHS A;  1TPG A;  2WII C;  1H04 P;  1U5M A;  2BZM A;  3ERB A;  1E88 A;  1GHQ B;  2MCZ A;  5HYP A;  1OK2 A;  2JRA A;  4CSY A;  4J38 B;  1ELV A;  5HYU B;  2CG7 A;  1UOT P;  3CAL A;  1HFI A;  2IZ3 A;  5JPM G;  2QY0 A;  3IX0 A;  1Q3X A;  2KMS A;  1SS2 A;  3SW0 X;  1VVC A;  3INB C;  1QO6 A;  2EHF A;  1MD7 A;  2RLP A;  1CKL A;  2XQW C;  1OK9 A;  2RKZ A;  2CKU A;  1VVD A;  1HCC A;  4IGD A;  4LOT A;  2B5I D;  2A55 A;  3O8E B;  3R62 A;  3OXU D;  1H03 P;  1C1Z A;  1PPQ A;  4WJG 2;  1G4G A;  1FBR A;  1LY2 A;  4DJZ A;  2RLQ A;  1OJV A;  4B2S A;  2YBY A;  3IU3 I;  3OED C;  4YNX A;  4C16 A;  1ZJK A;  2RKY A;  2V8E A;  2O39 C;  3GOV A;  1GKN A;  4AYE A;  2MCY A;  3ZD1 A;  3KZJ A;  3M7P A;  1SRZ A;  5FO8 C;  3RJ3 D;  3TVJ A;  2LOJ A;  4KKD A;  2G7I A;  1QUB A;  5I0Q B;  2ERJ A;  3GXE A;  2XWJ I;  4LOS A;  3KXV A;  3ZD2 A;  4AYM A;  1OK3 A;  1OJW A;  2JGW A;  4AYI A;  1H2Q P;  1G4F A;  1OK1 A;  1QGB A;  3OP8 A;  4AYD A;  2JGX A;  4ONT D;  1H2P P;  5HYT B;  1GPZ A;  3NFP I;  1NWV A;  3ZRZ A;  2UWN A;  4PZ5 A;  4F4O C;  2W80 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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