2XQWC

Structure of factor h domains 19-20 in complex with complement c3d
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
123
structure length
123
Chain Sequence
CGPPPPIDNGGITSFPLSVYAPASSVEYQCANLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Dual Interaction of Factor H with C3D and Glycosaminoglycans in Host-Nonhost Discrimination by Complement.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords COMPLEMENT C3
total genus 22
structure length 123
sequence length 123
ec nomenclature
pdb deposition date 2010-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2xqwC01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2xqwC02
1FBRA 5HYTB 1OK9A 1H04P 1VVDA 2O39C 2RLQA 3OEDC 4MUCA 2JGXA 2B5ID 3ERBA 4WJG2 3MQLA 3IU3I 2RKYA 3L89M 1PPQA 2XWBF 1MD8A 5HZPB 4AYMA 4C16A 4IGDA 2JRAA 1TPMA 4B2SA 2XRDA 1GHQB 1QO6A 2W80A 3M7PA 3T5OA 4B2RA 3INBC 1ZJKA 4LOTA 1OK1A 1HFIA 3O8EB 2LOJA 1HFHA 1NWVA 4FXGG 2ERJA 1E5GA 5FO8C 3ZD2A 1OJYA 1OK3A 2V8EA 1GKGA 1QUBA 2RLPA 1QGBA 5JPMG 2RKZA 1OJWA 2EC3A 2RL0A 2MCZA 2CG7A 4JHSA 1CKLA 2W81A 1LY2A 4PZ5A 2CKUA 1SRZA 3GXEA 2MCYA 1UOTP 1GKNA 2EHFA 3OXUD 2YBYA 2IZ4A 1OJVA 1H03P 1TPNA 3NFPI 1GPZA 1U5MA 3RJ3D 5I0QB 4CSYA 4AYEA 4ZH1D 3GOVA 1TPGA 1H2QP 2IZ3A 3OP8A 3R62A 4K12A 4ONTD 1C1ZA 2XRBA 1OK2A 4LOSA 1MD7A 2A55A 2CG6A 3EJHA 2WIIC 1Q3XA 5HYUB 4DJZA 2UWNA 2YRAA 3SW0X 2BZMA 3IX0A 4AYDA 4KKDA 2JGWA 3ZD1A 3ZRZA 3TVJA 1VVCA 3CALA 4J38B 5HYPA 3KXVA 2QY0A 1E88A 2KMSA 1H2PP 1G4FA 2G7IA 1O9AA 3KZJA 1ELVA 2XWJI 4F4OC 4AYIA 1E8BA 2XQWC 1SS2A 2KRIA 1G4GA 1HCCA 1Z92B 4A5WB 4YNXA
chains in the Genus database with same CATH superfamily
3FGTA 1FBRA 4PO7A 5HYTB 1OK9A 1H04P 1VVDA 2O39C 2RLQA 3OEDC 4MUCA 2JGXA 2B5ID 3ERBA 4WJG2 3MQLA 3IU3I 2RKYA 3L89M 3VWOA 1PPQA 2XWBF 1MD8A 3FGRA 5HZPB 4AYMA 3K3TA 4C16A 2I2LA 4IGDA 2JRAA 1TPMA 4B2SA 2XRDA 3WSYA 1GHQB 1QO6A 2W80A 3M7PA 3T5OA 4B2RA 3INBC 1ZJKA 4LOTA 1OK1A 1HFIA 1RLHA 3O8EB 2LOJA 1HFHA 1NWVA 4FXGG 2ERJA 1E5GA 2X2ZA 3NJAA 5FO8C 3ZLDA 3ZD2A 1OJYA 1OK3A 2V8EA 1GKGA 1QUBA 4BWCA 2RLPA 1QGBA 5JPMG 2RKZA 1OJWA 2ZYCA 2EC3A 2RL0A 2MCZA 2CG7A 4JHSA 1CKLA 2W81A 1LY2A 4PZ5A 2CKUA 1SRZA 3GXEA 2MCYA 1UOTP 1GKNA 2Y8SA 2EHFA 3OXUD 2YBYA 2IZ4A 1OJVA 5DN5A 1H03P 1TPNA 3NFPI 1GPZA 1U5MA 3RJ3D 5I0QB 4CSYA 4AYEA 4MSLA 4ZH1D 3GOVA 1TPGA 1H2QP 2IZ3A 3OP8A 3R62A 3WSXA 4K12A 4ONTD 1C1ZA 2XRBA 2Y8TA 1OK2A 4LOSA 1MD7A 2A55A 2CG6A 3EJHA 4N7EA 2WIIC 1Q3XA 5HYUB 4DJZA 2UWNA 2YRAA 3SW0X 2BZMA 3CI0J 3IX0A 4AYDA 4APLA 4KKDA 2JGWA 3ZLEA 3ZD1A 3ZRZA 3TVJA 1VVCA 3CALA 4J38B 5HYPA 3KXVA 2QY0A 3F6KA 5DN4A 1E88A 2KMSA 1H2PP 1G4FA 2G7IA 1O9AA 3KZJA 1ELVA 2XWJI 4YIZA 4F4OC 4AYIA 1E8BA 2XQWC 1SS2A 2KRIA 1G4GA 1HCCA 2Y8RA 1Z92B 4A5WB 4YNXA
chains in the Genus database with same CATH topology
1FBRA 5HYTB 1OK9A 1H04P 1VVDA 2O39C 2RLQA 3OEDC 4MUCA 2JGXA 2B5ID 3ERBA 4WJG2 3MQLA 3IU3I 2RKYA 3L89M 1PPQA 2XWBF 1MD8A 5HZPB 4AYMA 4C16A 4IGDA 2JRAA 1TPMA 4B2SA 2XRDA 1GHQB 1QO6A 2W80A 3M7PA 3T5OA 4B2RA 3INBC 1ZJKA 4LOTA 1OK1A 1HFIA 3O8EB 2LOJA 1HFHA 1NWVA 4FXGG 2ERJA 1E5GA 5FO8C 3ZD2A 1OJYA 1OK3A 2V8EA 1GKGA 1QUBA 2RLPA 1QGBA 5JPMG 2RKZA 1OJWA 2EC3A 2RL0A 2MCZA 2CG7A 4JHSA 1CKLA 2W81A 1LY2A 4PZ5A 2CKUA 1SRZA 3GXEA 2MCYA 1UOTP 1GKNA 2EHFA 3OXUD 2YBYA 2IZ4A 1OJVA 1H03P 1TPNA 3NFPI 1GPZA 1U5MA 3RJ3D 5I0QB 4CSYA 4AYEA 4ZH1D 3GOVA 1TPGA 1H2QP 2IZ3A 3OP8A 3R62A 4K12A 4ONTD 1C1ZA 2XRBA 1OK2A 4LOSA 1MD7A 2A55A 2CG6A 3EJHA 2WIIC 1Q3XA 5HYUB 4DJZA 2UWNA 2YRAA 3SW0X 2BZMA 3IX0A 4AYDA 4KKDA 2JGWA 3ZD1A 3ZRZA 3TVJA 1VVCA 3CALA 4J38B 5HYPA 3KXVA 2QY0A 1E88A 2KMSA 1H2PP 1G4FA 2G7IA 1O9AA 3KZJA 1ELVA 2XWJI 4F4OC 4AYIA 1E8BA 2XQWC 1SS2A 2KRIA 1G4GA 1HCCA 1Z92B 4A5WB 4YNXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FBR A;  5HYT B;  1OK9 A;  1H04 P;  1VVD A;  2O39 C;  2RLQ A;  3OED C;  4MUC A;  2JGX A;  2B5I D;  3ERB A;  4WJG 2;  3MQL A;  3IU3 I;  2RKY A;  3L89 M;  1PPQ A;  2XWB F;  1MD8 A;  5HZP B;  4AYM A;  4C16 A;  4IGD A;  2JRA A;  1TPM A;  4B2S A;  2XRD A;  1GHQ B;  1QO6 A;  2W80 A;  3M7P A;  3T5O A;  4B2R A;  3INB C;  1ZJK A;  4LOT A;  1OK1 A;  1HFI A;  3O8E B;  2LOJ A;  1HFH A;  1NWV A;  4FXG G;  2ERJ A;  1E5G A;  5FO8 C;  3ZD2 A;  1OJY A;  1OK3 A;  2V8E A;  1GKG A;  1QUB A;  2RLP A;  1QGB A;  5JPM G;  2RKZ A;  1OJW A;  2EC3 A;  2RL0 A;  2MCZ A;  2CG7 A;  4JHS A;  1CKL A;  2W81 A;  1LY2 A;  4PZ5 A;  2CKU A;  1SRZ A;  3GXE A;  2MCY A;  1UOT P;  1GKN A;  2EHF A;  3OXU D;  2YBY A;  2IZ4 A;  1OJV A;  1H03 P;  1TPN A;  3NFP I;  1GPZ A;  1U5M A;  3RJ3 D;  5I0Q B;  4CSY A;  4AYE A;  4ZH1 D;  3GOV A;  1TPG A;  1H2Q P;  2IZ3 A;  3OP8 A;  3R62 A;  4K12 A;  4ONT D;  1C1Z A;  2XRB A;  1OK2 A;  4LOS A;  1MD7 A;  2A55 A;  2CG6 A;  3EJH A;  2WII C;  1Q3X A;  5HYU B;  4DJZ A;  2UWN A;  2YRA A;  3SW0 X;  2BZM A;  3IX0 A;  4AYD A;  4KKD A;  2JGW A;  3ZD1 A;  3ZRZ A;  3TVJ A;  1VVC A;  3CAL A;  4J38 B;  5HYP A;  3KXV A;  2QY0 A;  1E88 A;  2KMS A;  1H2P P;  1G4F A;  2G7I A;  1O9A A;  3KZJ A;  1ELV A;  2XWJ I;  4F4O C;  4AYI A;  1E8B A;  2XQW C;  1SS2 A;  2KRI A;  1G4G A;  1HCC A;  1Z92 B;  4A5W B;  4YNX A; 
#chains in the Genus database with same CATH topology
 3FGT A;  1FBR A;  4PO7 A;  5HYT B;  1OK9 A;  1H04 P;  1VVD A;  2O39 C;  2RLQ A;  3OED C;  4MUC A;  2JGX A;  2B5I D;  3ERB A;  4WJG 2;  3MQL A;  3IU3 I;  2RKY A;  3L89 M;  3VWO A;  1PPQ A;  2XWB F;  1MD8 A;  3FGR A;  5HZP B;  4AYM A;  3K3T A;  4C16 A;  2I2L A;  4IGD A;  2JRA A;  1TPM A;  4B2S A;  2XRD A;  3WSY A;  1GHQ B;  1QO6 A;  2W80 A;  3M7P A;  3T5O A;  4B2R A;  3INB C;  1ZJK A;  4LOT A;  1OK1 A;  1HFI A;  1RLH A;  3O8E B;  2LOJ A;  1HFH A;  1NWV A;  4FXG G;  2ERJ A;  1E5G A;  2X2Z A;  3NJA A;  5FO8 C;  3ZLD A;  3ZD2 A;  1OJY A;  1OK3 A;  2V8E A;  1GKG A;  1QUB A;  4BWC A;  2RLP A;  1QGB A;  5JPM G;  2RKZ A;  1OJW A;  2ZYC A;  2EC3 A;  2RL0 A;  2MCZ A;  2CG7 A;  4JHS A;  1CKL A;  2W81 A;  1LY2 A;  4PZ5 A;  2CKU A;  1SRZ A;  3GXE A;  2MCY A;  1UOT P;  1GKN A;  2Y8S A;  2EHF A;  3OXU D;  2YBY A;  2IZ4 A;  1OJV A;  5DN5 A;  1H03 P;  1TPN A;  3NFP I;  1GPZ A;  1U5M A;  3RJ3 D;  5I0Q B;  4CSY A;  4AYE A;  4MSL A;  4ZH1 D;  3GOV A;  1TPG A;  1H2Q P;  2IZ3 A;  3OP8 A;  3R62 A;  3WSX A;  4K12 A;  4ONT D;  1C1Z A;  2XRB A;  2Y8T A;  1OK2 A;  4LOS A;  1MD7 A;  2A55 A;  2CG6 A;  3EJH A;  4N7E A;  2WII C;  1Q3X A;  5HYU B;  4DJZ A;  2UWN A;  2YRA A;  3SW0 X;  2BZM A;  3CI0 J;  3IX0 A;  4AYD A;  4APL A;  4KKD A;  2JGW A;  3ZLE A;  3ZD1 A;  3ZRZ A;  3TVJ A;  1VVC A;  3CAL A;  4J38 B;  5HYP A;  3KXV A;  2QY0 A;  3F6K A;  5DN4 A;  1E88 A;  2KMS A;  1H2P P;  1G4F A;  2G7I A;  1O9A A;  3KZJ A;  1ELV A;  2XWJ I;  4YIZ A;  4F4O C;  4AYI A;  1E8B A;  2XQW C;  1SS2 A;  2KRI A;  1G4G A;  1HCC A;  2Y8R A;  1Z92 B;  4A5W B;  4YNX A; 
#chains in the Genus database with same CATH homology
 1FBR A;  5HYT B;  1OK9 A;  1H04 P;  1VVD A;  2O39 C;  2RLQ A;  3OED C;  4MUC A;  2JGX A;  2B5I D;  3ERB A;  4WJG 2;  3MQL A;  3IU3 I;  2RKY A;  3L89 M;  1PPQ A;  2XWB F;  1MD8 A;  5HZP B;  4AYM A;  4C16 A;  4IGD A;  2JRA A;  1TPM A;  4B2S A;  2XRD A;  1GHQ B;  1QO6 A;  2W80 A;  3M7P A;  3T5O A;  4B2R A;  3INB C;  1ZJK A;  4LOT A;  1OK1 A;  1HFI A;  3O8E B;  2LOJ A;  1HFH A;  1NWV A;  4FXG G;  2ERJ A;  1E5G A;  5FO8 C;  3ZD2 A;  1OJY A;  1OK3 A;  2V8E A;  1GKG A;  1QUB A;  2RLP A;  1QGB A;  5JPM G;  2RKZ A;  1OJW A;  2EC3 A;  2RL0 A;  2MCZ A;  2CG7 A;  4JHS A;  1CKL A;  2W81 A;  1LY2 A;  4PZ5 A;  2CKU A;  1SRZ A;  3GXE A;  2MCY A;  1UOT P;  1GKN A;  2EHF A;  3OXU D;  2YBY A;  2IZ4 A;  1OJV A;  1H03 P;  1TPN A;  3NFP I;  1GPZ A;  1U5M A;  3RJ3 D;  5I0Q B;  4CSY A;  4AYE A;  4ZH1 D;  3GOV A;  1TPG A;  1H2Q P;  2IZ3 A;  3OP8 A;  3R62 A;  4K12 A;  4ONT D;  1C1Z A;  2XRB A;  1OK2 A;  4LOS A;  1MD7 A;  2A55 A;  2CG6 A;  3EJH A;  2WII C;  1Q3X A;  5HYU B;  4DJZ A;  2UWN A;  2YRA A;  3SW0 X;  2BZM A;  3IX0 A;  4AYD A;  4KKD A;  2JGW A;  3ZD1 A;  3ZRZ A;  3TVJ A;  1VVC A;  3CAL A;  4J38 B;  5HYP A;  3KXV A;  2QY0 A;  1E88 A;  2KMS A;  1H2P P;  1G4F A;  2G7I A;  1O9A A;  3KZJ A;  1ELV A;  2XWJ I;  4F4O C;  4AYI A;  1E8B A;  2XQW C;  1SS2 A;  2KRI A;  1G4G A;  1HCC A;  1Z92 B;  4A5W B;  4YNX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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