2XQWC

Structure of factor h domains 19-20 in complex with complement c3d
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
123
structure length
123
Chain Sequence
CGPPPPIDNGGITSFPLSVYAPASSVEYQCANLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
source organism Homo sapiens
publication title Dual Interaction of Factor H with C3D and Glycosaminoglycans in Host-Nonhost Discrimination by Complement.
pubmed doi rcsb
molecule keywords COMPLEMENT C3
total genus 22
structure length 123
sequence length 123
ec nomenclature
pdb deposition date 2010-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2xqwC01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2xqwC02
1OJVA 3ZD1A 2XWJI 3R62A 5FO8C 1QO6A 2JRAA 3IU3I 2BZMA 5JPMG 3O8EB 3KZJA 3ZRZA 4J38B 4PZ5A 2RLPA 3OP8A 3IX0A 4LOSA 4ONTD 2RKZA 2XRDA 3ZD2A 1GKGA 1HFIA 4FXGG 4IGDA 4CSYA 1G4FA 4B2RA 5I0QB 2MCZA 3GOVA 1SRZA 3M7PA 1GKNA 2CG6A 4C16A 2KRIA 2O39C 5HYTB 4MUCA 4ZH1D 1HFHA 2QY0A 1OK9A 2JGXA 2LOJA 3ERBA 1O9AA 1OK2A 2WIIC 1VVDA 1OK1A 1H2QP 1HCCA 1UOTP 2W81A 1GHQB 1E5GA 3INBC 3SW0X 2EHFA 3NFPI 4K12A 4KKDA 2B5ID 5HZPB 1FBRA 1H2PP 1ZJKA 1G4GA 1C1ZA 3CALA 4B2SA 3TVJA 2CG7A 2YBYA 1E88A 1NWVA 1LY2A 2UWNA 1TPMA 3GXEA 4AYMA 4AYIA 2IZ3A 1ELVA 2RLQA 4A5WB 1SS2A 1OK3A 2XWBF 2JGWA 4LOTA 2RKYA 3RJ3D 2EC3A 3L89M 4YNXA 1QGBA 5HYPA 2XQWC 3KXVA 1OJWA 2KMSA 1Q3XA 5HYUB 1QUBA 1E8BA 1U5MA 1MD8A 1TPGA 2A55A 4DJZA 1CKLA 1TPNA 1VVCA 4AYEA 1MD7A 2RL0A 2IZ4A 3T5OA 4WJG2 2W80A 2V8EA 3MQLA 2XRBA 1OJYA 1GPZA 1Z92B 3OXUD 4JHSA 4AYDA 2CKUA 1H03P 4F4OC 2MCYA 3OEDC 1H04P 1PPQA 2ERJA 2G7IA 3EJHA 2YRAA
chains in the Genus database with same CATH superfamily
1OJVA 3ZD1A 2I2LA 2XWJI 3WSYA 3R62A 5FO8C 1QO6A 2JRAA 3IU3I 2BZMA 5JPMG 3O8EB 3KZJA 3ZRZA 4J38B 4PZ5A 2RLPA 3OP8A 2Y8TA 3IX0A 4LOSA 4ONTD 2RKZA 4PO7A 2XRDA 3ZD2A 1GKGA 1HFIA 4FXGG 4IGDA 4CSYA 1G4FA 4B2RA 5I0QB 2MCZA 3GOVA 1SRZA 3M7PA 1GKNA 2CG6A 4C16A 4APLA 2KRIA 2O39C 5HYTB 4MUCA 4ZH1D 1HFHA 5DN5A 2QY0A 1OK9A 3CI0J 4YIZA 2JGXA 2LOJA 3ZLDA 3ERBA 1O9AA 1OK2A 2WIIC 3WSXA 1VVDA 1OK1A 3K3TA 1H2QP 1HCCA 1UOTP 2W81A 1GHQB 1E5GA 3INBC 3SW0X 2EHFA 3NFPI 4K12A 4KKDA 2B5ID 5HZPB 1FBRA 1H2PP 1ZJKA 4N7EA 1G4GA 1RLHA 5DN4A 1C1ZA 2Y8SA 3CALA 4B2SA 3TVJA 2CG7A 2YBYA 1E88A 3F6KA 3ZLEA 1NWVA 1LY2A 4MSLA 2UWNA 1TPMA 3GXEA 4AYMA 4AYIA 2IZ3A 1ELVA 2RLQA 4A5WB 1SS2A 1OK3A 2XWBF 2X2ZA 2JGWA 4LOTA 2RKYA 3RJ3D 2EC3A 3L89M 3NJAA 4YNXA 2ZYCA 1QGBA 5HYPA 2XQWC 3KXVA 1OJWA 2KMSA 1Q3XA 5HYUB 3FGTA 1QUBA 1E8BA 1U5MA 1MD8A 1TPGA 2A55A 4DJZA 1CKLA 1TPNA 1VVCA 4AYEA 1MD7A 2RL0A 2IZ4A 3T5OA 4WJG2 2W80A 2Y8RA 2V8EA 3MQLA 2XRBA 1OJYA 4BWCA 1GPZA 1Z92B 3OXUD 4JHSA 4AYDA 2CKUA 1H03P 4F4OC 3FGRA 3VWOA 2MCYA 3OEDC 1H04P 1PPQA 2ERJA 2G7IA 3EJHA 2YRAA
chains in the Genus database with same CATH topology
1OJVA 3ZD1A 2XWJI 3R62A 5FO8C 1QO6A 2JRAA 3IU3I 2BZMA 5JPMG 3O8EB 3KZJA 3ZRZA 4J38B 4PZ5A 2RLPA 3OP8A 3IX0A 4LOSA 4ONTD 2RKZA 2XRDA 3ZD2A 1GKGA 1HFIA 4FXGG 4IGDA 4CSYA 1G4FA 4B2RA 5I0QB 2MCZA 3GOVA 1SRZA 3M7PA 1GKNA 2CG6A 4C16A 2KRIA 2O39C 5HYTB 4MUCA 4ZH1D 1HFHA 2QY0A 1OK9A 2JGXA 2LOJA 3ERBA 1O9AA 1OK2A 2WIIC 1VVDA 1OK1A 1H2QP 1HCCA 1UOTP 2W81A 1GHQB 1E5GA 3INBC 3SW0X 2EHFA 3NFPI 4K12A 4KKDA 2B5ID 5HZPB 1FBRA 1H2PP 1ZJKA 1G4GA 1C1ZA 3CALA 4B2SA 3TVJA 2CG7A 2YBYA 1E88A 1NWVA 1LY2A 2UWNA 1TPMA 3GXEA 4AYMA 4AYIA 2IZ3A 1ELVA 2RLQA 4A5WB 1SS2A 1OK3A 2XWBF 2JGWA 4LOTA 2RKYA 3RJ3D 2EC3A 3L89M 4YNXA 1QGBA 5HYPA 2XQWC 3KXVA 1OJWA 2KMSA 1Q3XA 5HYUB 1QUBA 1E8BA 1U5MA 1MD8A 1TPGA 2A55A 4DJZA 1CKLA 1TPNA 1VVCA 4AYEA 1MD7A 2RL0A 2IZ4A 3T5OA 4WJG2 2W80A 2V8EA 3MQLA 2XRBA 1OJYA 1GPZA 1Z92B 3OXUD 4JHSA 4AYDA 2CKUA 1H03P 4F4OC 2MCYA 3OEDC 1H04P 1PPQA 2ERJA 2G7IA 3EJHA 2YRAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OJV A;  3ZD1 A;  2XWJ I;  3R62 A;  5FO8 C;  1QO6 A;  2JRA A;  3IU3 I;  2BZM A;  5JPM G;  3O8E B;  3KZJ A;  3ZRZ A;  4J38 B;  4PZ5 A;  2RLP A;  3OP8 A;  3IX0 A;  4LOS A;  4ONT D;  2RKZ A;  2XRD A;  3ZD2 A;  1GKG A;  1HFI A;  4FXG G;  4IGD A;  4CSY A;  1G4F A;  4B2R A;  5I0Q B;  2MCZ A;  3GOV A;  1SRZ A;  3M7P A;  1GKN A;  2CG6 A;  4C16 A;  2KRI A;  2O39 C;  5HYT B;  4MUC A;  4ZH1 D;  1HFH A;  2QY0 A;  1OK9 A;  2JGX A;  2LOJ A;  3ERB A;  1O9A A;  1OK2 A;  2WII C;  1VVD A;  1OK1 A;  1H2Q P;  1HCC A;  1UOT P;  2W81 A;  1GHQ B;  1E5G A;  3INB C;  3SW0 X;  2EHF A;  3NFP I;  4K12 A;  4KKD A;  2B5I D;  5HZP B;  1FBR A;  1H2P P;  1ZJK A;  1G4G A;  1C1Z A;  3CAL A;  4B2S A;  3TVJ A;  2CG7 A;  2YBY A;  1E88 A;  1NWV A;  1LY2 A;  2UWN A;  1TPM A;  3GXE A;  4AYM A;  4AYI A;  2IZ3 A;  1ELV A;  2RLQ A;  4A5W B;  1SS2 A;  1OK3 A;  2XWB F;  2JGW A;  4LOT A;  2RKY A;  3RJ3 D;  2EC3 A;  3L89 M;  4YNX A;  1QGB A;  5HYP A;  2XQW C;  3KXV A;  1OJW A;  2KMS A;  1Q3X A;  5HYU B;  1QUB A;  1E8B A;  1U5M A;  1MD8 A;  1TPG A;  2A55 A;  4DJZ A;  1CKL A;  1TPN A;  1VVC A;  4AYE A;  1MD7 A;  2RL0 A;  2IZ4 A;  3T5O A;  4WJG 2;  2W80 A;  2V8E A;  3MQL A;  2XRB A;  1OJY A;  1GPZ A;  1Z92 B;  3OXU D;  4JHS A;  4AYD A;  2CKU A;  1H03 P;  4F4O C;  2MCY A;  3OED C;  1H04 P;  1PPQ A;  2ERJ A;  2G7I A;  3EJH A;  2YRA A; 
#chains in the Genus database with same CATH topology
 1OJV A;  3ZD1 A;  2I2L A;  2XWJ I;  3WSY A;  3R62 A;  5FO8 C;  1QO6 A;  2JRA A;  3IU3 I;  2BZM A;  5JPM G;  3O8E B;  3KZJ A;  3ZRZ A;  4J38 B;  4PZ5 A;  2RLP A;  3OP8 A;  2Y8T A;  3IX0 A;  4LOS A;  4ONT D;  2RKZ A;  4PO7 A;  2XRD A;  3ZD2 A;  1GKG A;  1HFI A;  4FXG G;  4IGD A;  4CSY A;  1G4F A;  4B2R A;  5I0Q B;  2MCZ A;  3GOV A;  1SRZ A;  3M7P A;  1GKN A;  2CG6 A;  4C16 A;  4APL A;  2KRI A;  2O39 C;  5HYT B;  4MUC A;  4ZH1 D;  1HFH A;  5DN5 A;  2QY0 A;  1OK9 A;  3CI0 J;  4YIZ A;  2JGX A;  2LOJ A;  3ZLD A;  3ERB A;  1O9A A;  1OK2 A;  2WII C;  3WSX A;  1VVD A;  1OK1 A;  3K3T A;  1H2Q P;  1HCC A;  1UOT P;  2W81 A;  1GHQ B;  1E5G A;  3INB C;  3SW0 X;  2EHF A;  3NFP I;  4K12 A;  4KKD A;  2B5I D;  5HZP B;  1FBR A;  1H2P P;  1ZJK A;  4N7E A;  1G4G A;  1RLH A;  5DN4 A;  1C1Z A;  2Y8S A;  3CAL A;  4B2S A;  3TVJ A;  2CG7 A;  2YBY A;  1E88 A;  3F6K A;  3ZLE A;  1NWV A;  1LY2 A;  4MSL A;  2UWN A;  1TPM A;  3GXE A;  4AYM A;  4AYI A;  2IZ3 A;  1ELV A;  2RLQ A;  4A5W B;  1SS2 A;  1OK3 A;  2XWB F;  2X2Z A;  2JGW A;  4LOT A;  2RKY A;  3RJ3 D;  2EC3 A;  3L89 M;  3NJA A;  4YNX A;  2ZYC A;  1QGB A;  5HYP A;  2XQW C;  3KXV A;  1OJW A;  2KMS A;  1Q3X A;  5HYU B;  3FGT A;  1QUB A;  1E8B A;  1U5M A;  1MD8 A;  1TPG A;  2A55 A;  4DJZ A;  1CKL A;  1TPN A;  1VVC A;  4AYE A;  1MD7 A;  2RL0 A;  2IZ4 A;  3T5O A;  4WJG 2;  2W80 A;  2Y8R A;  2V8E A;  3MQL A;  2XRB A;  1OJY A;  4BWC A;  1GPZ A;  1Z92 B;  3OXU D;  4JHS A;  4AYD A;  2CKU A;  1H03 P;  4F4O C;  3FGR A;  3VWO A;  2MCY A;  3OED C;  1H04 P;  1PPQ A;  2ERJ A;  2G7I A;  3EJH A;  2YRA A; 
#chains in the Genus database with same CATH homology
 1OJV A;  3ZD1 A;  2XWJ I;  3R62 A;  5FO8 C;  1QO6 A;  2JRA A;  3IU3 I;  2BZM A;  5JPM G;  3O8E B;  3KZJ A;  3ZRZ A;  4J38 B;  4PZ5 A;  2RLP A;  3OP8 A;  3IX0 A;  4LOS A;  4ONT D;  2RKZ A;  2XRD A;  3ZD2 A;  1GKG A;  1HFI A;  4FXG G;  4IGD A;  4CSY A;  1G4F A;  4B2R A;  5I0Q B;  2MCZ A;  3GOV A;  1SRZ A;  3M7P A;  1GKN A;  2CG6 A;  4C16 A;  2KRI A;  2O39 C;  5HYT B;  4MUC A;  4ZH1 D;  1HFH A;  2QY0 A;  1OK9 A;  2JGX A;  2LOJ A;  3ERB A;  1O9A A;  1OK2 A;  2WII C;  1VVD A;  1OK1 A;  1H2Q P;  1HCC A;  1UOT P;  2W81 A;  1GHQ B;  1E5G A;  3INB C;  3SW0 X;  2EHF A;  3NFP I;  4K12 A;  4KKD A;  2B5I D;  5HZP B;  1FBR A;  1H2P P;  1ZJK A;  1G4G A;  1C1Z A;  3CAL A;  4B2S A;  3TVJ A;  2CG7 A;  2YBY A;  1E88 A;  1NWV A;  1LY2 A;  2UWN A;  1TPM A;  3GXE A;  4AYM A;  4AYI A;  2IZ3 A;  1ELV A;  2RLQ A;  4A5W B;  1SS2 A;  1OK3 A;  2XWB F;  2JGW A;  4LOT A;  2RKY A;  3RJ3 D;  2EC3 A;  3L89 M;  4YNX A;  1QGB A;  5HYP A;  2XQW C;  3KXV A;  1OJW A;  2KMS A;  1Q3X A;  5HYU B;  1QUB A;  1E8B A;  1U5M A;  1MD8 A;  1TPG A;  2A55 A;  4DJZ A;  1CKL A;  1TPN A;  1VVC A;  4AYE A;  1MD7 A;  2RL0 A;  2IZ4 A;  3T5O A;  4WJG 2;  2W80 A;  2V8E A;  3MQL A;  2XRB A;  1OJY A;  1GPZ A;  1Z92 B;  3OXU D;  4JHS A;  4AYD A;  2CKU A;  1H03 P;  4F4O C;  2MCY A;  3OED C;  1H04 P;  1PPQ A;  2ERJ A;  2G7I A;  3EJH A;  2YRA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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