3ERBA

The crystal structure of c2b, a fragment of complement component c2 produced during c3-convertase formation
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
195
structure length
188
Chain Sequence
SCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Complement C2
total genus 36
structure length 188
sequence length 195
ec nomenclature ec 3.4.21.43: Classical-complement-pathway C3/C5 convertase.
pdb deposition date 2008-10-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3erbA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3erbA03
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3erbA01
1ELVA 2XWJI 3ZRZA 1H2QP 4AYEA 4A5WB 4C16A 1GKGA 2KRIA 2UWNA 3T5OA 1GHQB 1CKLA 4ZH1D 1ZJKA 4FXGG 1HFIA 2JRAA 3EJHA 1E88A 2MCYA 3CALA 1MD7A 1OK9A 3NFPI 5I0QB 4PZ5A 1SRZA 4J38B 1E5GA 3TVJA 1HFHA 1O9AA 2CG6A 2XRDA 2W80A 1Z92B 5FO8C 2RKZA 2XRBA 2QY0A 4JHSA 1TPMA 4WJG2 2RKYA 3IX0A 1OJVA 3OEDC 3OXUD 1OJYA 3SW0X 1SS2A 2XQWC 2RL0A 4LOTA 1NWVA 1TPNA 2IZ3A 1Q3XA 2A55A 1FBRA 2JGXA 3RJ3D 3OP8A 1GPZA 1OK3A 4IGDA 2YBYA 3ZD1A 5JPMG 2O39C 2BZMA 2KMSA 2G7IA 1G4FA 2XWBF 2W81A 1U5MA 2EHFA 2JGWA 3ERBA 1C1ZA 4CSYA 2B5ID 4AYIA 4K12A 1H04P 4AYDA 2CG7A 1PPQA 4LOSA 5HYPA 3M7PA 2EC3A 4B2RA 2ERJA 2RLPA 3KXVA 1MD8A 3INBC 1VVCA 2WIIC 1GKNA 1LY2A 2RLQA 4KKDA 1HCCA 2MCZA 1OJWA 3GOVA 3MQLA 2CKUA 2V8EA 1H03P 1VVDA 4ONTD 4MUCA 3ZD2A 5HYUB 5HZPB 4YNXA 2YRAA 4AYMA 1OK2A 3O8EB 1UOTP 3L89M 3IU3I 1TPGA 1E8BA 1H2PP 1QGBA 1QUBA 3R62A 3KZJA 2LOJA 4DJZA 1G4GA 2IZ4A 4B2SA 3GXEA 1OK1A 1QO6A 5HYTB 4F4OC
chains in the Genus database with same CATH superfamily
4APLA 1ELVA 2XWJI 3ZRZA 1H2QP 4AYEA 4A5WB 4C16A 1GKGA 2KRIA 2UWNA 3T5OA 3FGRA 1GHQB 1CKLA 4ZH1D 1ZJKA 4FXGG 1HFIA 2JRAA 3EJHA 1E88A 4BWCA 2MCYA 3CALA 1MD7A 3WSYA 2Y8SA 1OK9A 3NFPI 5I0QB 4PZ5A 3WSXA 1SRZA 4J38B 1E5GA 3TVJA 1HFHA 1O9AA 2CG6A 2XRDA 2W80A 4PO7A 1Z92B 5FO8C 2RKZA 2XRBA 2QY0A 4JHSA 4YIZA 1TPMA 4WJG2 2RKYA 3IX0A 1OJVA 3OEDC 3OXUD 1OJYA 3SW0X 1SS2A 3ZLDA 2XQWC 2RL0A 4LOTA 2Y8RA 1NWVA 1TPNA 2IZ3A 1Q3XA 2A55A 1FBRA 3VWOA 2JGXA 3RJ3D 3OP8A 1GPZA 1OK3A 4IGDA 2X2ZA 2YBYA 3ZD1A 5JPMG 4N7EA 2O39C 2BZMA 2KMSA 2ZYCA 2G7IA 1G4FA 2XWBF 2W81A 1U5MA 2EHFA 2JGWA 3ERBA 1C1ZA 4CSYA 2B5ID 4AYIA 4K12A 2Y8TA 1H04P 4AYDA 2CG7A 1PPQA 3K3TA 4LOSA 5HYPA 3M7PA 2EC3A 4B2RA 2ERJA 2RLPA 3KXVA 1MD8A 3INBC 1VVCA 2WIIC 1RLHA 1GKNA 3F6KA 1LY2A 2RLQA 5DN4A 4KKDA 3FGTA 1HCCA 2MCZA 1OJWA 3GOVA 3MQLA 5DN5A 2CKUA 2V8EA 1H03P 1VVDA 4ONTD 4MUCA 3ZD2A 3CI0J 5HYUB 5HZPB 4YNXA 2YRAA 4AYMA 1OK2A 3O8EB 1UOTP 3L89M 3IU3I 1TPGA 3ZLEA 1E8BA 1H2PP 1QGBA 1QUBA 3R62A 3KZJA 2LOJA 4DJZA 4MSLA 1G4GA 2IZ4A 4B2SA 3GXEA 3NJAA 1OK1A 1QO6A 2I2LA 5HYTB 4F4OC
chains in the Genus database with same CATH topology
1ELVA 2XWJI 3ZRZA 1H2QP 4AYEA 4A5WB 4C16A 1GKGA 2KRIA 2UWNA 3T5OA 1GHQB 1CKLA 4ZH1D 1ZJKA 4FXGG 1HFIA 2JRAA 3EJHA 1E88A 2MCYA 3CALA 1MD7A 1OK9A 3NFPI 5I0QB 4PZ5A 1SRZA 4J38B 1E5GA 3TVJA 1HFHA 1O9AA 2CG6A 2XRDA 2W80A 1Z92B 5FO8C 2RKZA 2XRBA 2QY0A 4JHSA 1TPMA 4WJG2 2RKYA 3IX0A 1OJVA 3OEDC 3OXUD 1OJYA 3SW0X 1SS2A 2XQWC 2RL0A 4LOTA 1NWVA 1TPNA 2IZ3A 1Q3XA 2A55A 1FBRA 2JGXA 3RJ3D 3OP8A 1GPZA 1OK3A 4IGDA 2YBYA 3ZD1A 5JPMG 2O39C 2BZMA 2KMSA 2G7IA 1G4FA 2XWBF 2W81A 1U5MA 2EHFA 2JGWA 3ERBA 1C1ZA 4CSYA 2B5ID 4AYIA 4K12A 1H04P 4AYDA 2CG7A 1PPQA 4LOSA 5HYPA 3M7PA 2EC3A 4B2RA 2ERJA 2RLPA 3KXVA 1MD8A 3INBC 1VVCA 2WIIC 1GKNA 1LY2A 2RLQA 4KKDA 1HCCA 2MCZA 1OJWA 3GOVA 3MQLA 2CKUA 2V8EA 1H03P 1VVDA 4ONTD 4MUCA 3ZD2A 5HYUB 5HZPB 4YNXA 2YRAA 4AYMA 1OK2A 3O8EB 1UOTP 3L89M 3IU3I 1TPGA 1E8BA 1H2PP 1QGBA 1QUBA 3R62A 3KZJA 2LOJA 4DJZA 1G4GA 2IZ4A 4B2SA 3GXEA 1OK1A 1QO6A 5HYTB 4F4OC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ELV A;  2XWJ I;  3ZRZ A;  1H2Q P;  4AYE A;  4A5W B;  4C16 A;  1GKG A;  2KRI A;  2UWN A;  3T5O A;  1GHQ B;  1CKL A;  4ZH1 D;  1ZJK A;  4FXG G;  1HFI A;  2JRA A;  3EJH A;  1E88 A;  2MCY A;  3CAL A;  1MD7 A;  1OK9 A;  3NFP I;  5I0Q B;  4PZ5 A;  1SRZ A;  4J38 B;  1E5G A;  3TVJ A;  1HFH A;  1O9A A;  2CG6 A;  2XRD A;  2W80 A;  1Z92 B;  5FO8 C;  2RKZ A;  2XRB A;  2QY0 A;  4JHS A;  1TPM A;  4WJG 2;  2RKY A;  3IX0 A;  1OJV A;  3OED C;  3OXU D;  1OJY A;  3SW0 X;  1SS2 A;  2XQW C;  2RL0 A;  4LOT A;  1NWV A;  1TPN A;  2IZ3 A;  1Q3X A;  2A55 A;  1FBR A;  2JGX A;  3RJ3 D;  3OP8 A;  1GPZ A;  1OK3 A;  4IGD A;  2YBY A;  3ZD1 A;  5JPM G;  2O39 C;  2BZM A;  2KMS A;  2G7I A;  1G4F A;  2XWB F;  2W81 A;  1U5M A;  2EHF A;  2JGW A;  3ERB A;  1C1Z A;  4CSY A;  2B5I D;  4AYI A;  4K12 A;  1H04 P;  4AYD A;  2CG7 A;  1PPQ A;  4LOS A;  5HYP A;  3M7P A;  2EC3 A;  4B2R A;  2ERJ A;  2RLP A;  3KXV A;  1MD8 A;  3INB C;  1VVC A;  2WII C;  1GKN A;  1LY2 A;  2RLQ A;  4KKD A;  1HCC A;  2MCZ A;  1OJW A;  3GOV A;  3MQL A;  2CKU A;  2V8E A;  1H03 P;  1VVD A;  4ONT D;  4MUC A;  3ZD2 A;  5HYU B;  5HZP B;  4YNX A;  2YRA A;  4AYM A;  1OK2 A;  3O8E B;  1UOT P;  3L89 M;  3IU3 I;  1TPG A;  1E8B A;  1H2P P;  1QGB A;  1QUB A;  3R62 A;  3KZJ A;  2LOJ A;  4DJZ A;  1G4G A;  2IZ4 A;  4B2S A;  3GXE A;  1OK1 A;  1QO6 A;  5HYT B;  4F4O C; 
#chains in the Genus database with same CATH topology
 4APL A;  1ELV A;  2XWJ I;  3ZRZ A;  1H2Q P;  4AYE A;  4A5W B;  4C16 A;  1GKG A;  2KRI A;  2UWN A;  3T5O A;  3FGR A;  1GHQ B;  1CKL A;  4ZH1 D;  1ZJK A;  4FXG G;  1HFI A;  2JRA A;  3EJH A;  1E88 A;  4BWC A;  2MCY A;  3CAL A;  1MD7 A;  3WSY A;  2Y8S A;  1OK9 A;  3NFP I;  5I0Q B;  4PZ5 A;  3WSX A;  1SRZ A;  4J38 B;  1E5G A;  3TVJ A;  1HFH A;  1O9A A;  2CG6 A;  2XRD A;  2W80 A;  4PO7 A;  1Z92 B;  5FO8 C;  2RKZ A;  2XRB A;  2QY0 A;  4JHS A;  4YIZ A;  1TPM A;  4WJG 2;  2RKY A;  3IX0 A;  1OJV A;  3OED C;  3OXU D;  1OJY A;  3SW0 X;  1SS2 A;  3ZLD A;  2XQW C;  2RL0 A;  4LOT A;  2Y8R A;  1NWV A;  1TPN A;  2IZ3 A;  1Q3X A;  2A55 A;  1FBR A;  3VWO A;  2JGX A;  3RJ3 D;  3OP8 A;  1GPZ A;  1OK3 A;  4IGD A;  2X2Z A;  2YBY A;  3ZD1 A;  5JPM G;  4N7E A;  2O39 C;  2BZM A;  2KMS A;  2ZYC A;  2G7I A;  1G4F A;  2XWB F;  2W81 A;  1U5M A;  2EHF A;  2JGW A;  3ERB A;  1C1Z A;  4CSY A;  2B5I D;  4AYI A;  4K12 A;  2Y8T A;  1H04 P;  4AYD A;  2CG7 A;  1PPQ A;  3K3T A;  4LOS A;  5HYP A;  3M7P A;  2EC3 A;  4B2R A;  2ERJ A;  2RLP A;  3KXV A;  1MD8 A;  3INB C;  1VVC A;  2WII C;  1RLH A;  1GKN A;  3F6K A;  1LY2 A;  2RLQ A;  5DN4 A;  4KKD A;  3FGT A;  1HCC A;  2MCZ A;  1OJW A;  3GOV A;  3MQL A;  5DN5 A;  2CKU A;  2V8E A;  1H03 P;  1VVD A;  4ONT D;  4MUC A;  3ZD2 A;  3CI0 J;  5HYU B;  5HZP B;  4YNX A;  2YRA A;  4AYM A;  1OK2 A;  3O8E B;  1UOT P;  3L89 M;  3IU3 I;  1TPG A;  3ZLE A;  1E8B A;  1H2P P;  1QGB A;  1QUB A;  3R62 A;  3KZJ A;  2LOJ A;  4DJZ A;  4MSL A;  1G4G A;  2IZ4 A;  4B2S A;  3GXE A;  3NJA A;  1OK1 A;  1QO6 A;  2I2L A;  5HYT B;  4F4O C; 
#chains in the Genus database with same CATH homology
 1ELV A;  2XWJ I;  3ZRZ A;  1H2Q P;  4AYE A;  4A5W B;  4C16 A;  1GKG A;  2KRI A;  2UWN A;  3T5O A;  1GHQ B;  1CKL A;  4ZH1 D;  1ZJK A;  4FXG G;  1HFI A;  2JRA A;  3EJH A;  1E88 A;  2MCY A;  3CAL A;  1MD7 A;  1OK9 A;  3NFP I;  5I0Q B;  4PZ5 A;  1SRZ A;  4J38 B;  1E5G A;  3TVJ A;  1HFH A;  1O9A A;  2CG6 A;  2XRD A;  2W80 A;  1Z92 B;  5FO8 C;  2RKZ A;  2XRB A;  2QY0 A;  4JHS A;  1TPM A;  4WJG 2;  2RKY A;  3IX0 A;  1OJV A;  3OED C;  3OXU D;  1OJY A;  3SW0 X;  1SS2 A;  2XQW C;  2RL0 A;  4LOT A;  1NWV A;  1TPN A;  2IZ3 A;  1Q3X A;  2A55 A;  1FBR A;  2JGX A;  3RJ3 D;  3OP8 A;  1GPZ A;  1OK3 A;  4IGD A;  2YBY A;  3ZD1 A;  5JPM G;  2O39 C;  2BZM A;  2KMS A;  2G7I A;  1G4F A;  2XWB F;  2W81 A;  1U5M A;  2EHF A;  2JGW A;  3ERB A;  1C1Z A;  4CSY A;  2B5I D;  4AYI A;  4K12 A;  1H04 P;  4AYD A;  2CG7 A;  1PPQ A;  4LOS A;  5HYP A;  3M7P A;  2EC3 A;  4B2R A;  2ERJ A;  2RLP A;  3KXV A;  1MD8 A;  3INB C;  1VVC A;  2WII C;  1GKN A;  1LY2 A;  2RLQ A;  4KKD A;  1HCC A;  2MCZ A;  1OJW A;  3GOV A;  3MQL A;  2CKU A;  2V8E A;  1H03 P;  1VVD A;  4ONT D;  4MUC A;  3ZD2 A;  5HYU B;  5HZP B;  4YNX A;  2YRA A;  4AYM A;  1OK2 A;  3O8E B;  1UOT P;  3L89 M;  3IU3 I;  1TPG A;  1E8B A;  1H2P P;  1QGB A;  1QUB A;  3R62 A;  3KZJ A;  2LOJ A;  4DJZ A;  1G4G A;  2IZ4 A;  4B2S A;  3GXE A;  1OK1 A;  1QO6 A;  5HYT B;  4F4O C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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