3KZJA

Structure of complement factor h variant r1203a
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
125
structure length
125
Chain Sequence
TGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKAGYRLSSRSHTLRTTCWDGKLEYPTCAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 26
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2009-12-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3kzjA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3kzjA02
4IGDA 4WJG2 1C1ZA 2KMSA 2A55A 1PPQA 1TPGA 1VVCA 1TPMA 2JGWA 1FBRA 1H04P 1QO6A 3ZD1A 3L89M 2IZ3A 2W80A 5I0QB 3KZJA 4K12A 4AYMA 4ZH1D 3TVJA 1OK3A 3NFPI 2QY0A 2MCZA 1SRZA 2XRBA 1E5GA 1TPNA 1Z92B 2XWJI 1MD7A 2UWNA 1H03P 1U5MA 1G4FA 2YRAA 1HCCA 1NWVA 2XWBF 2RLPA 4B2SA 1OK2A 2CG6A 4KKDA 1OJWA 2MCYA 2XRDA 4LOTA 1E88A 2EC3A 2B5ID 2BZMA 4JHSA 4YNXA 5JPMG 1LY2A 2RLQA 3M7PA 1OJVA 2RKZA 4B2RA 3ZRZA 1CKLA 2IZ4A 5HZPB 1OK1A 2KRIA 3ZD2A 2YBYA 4AYDA 5HYUB 1HFIA 3EJHA 3KXVA 4DJZA 3OEDC 3RJ3D 2W81A 1GKGA 3OP8A 1UOTP 3ERBA 4ONTD 4AYEA 1GHQB 3INBC 3GXEA 5HYTB 4CSYA 4A5WB 2JGXA 3OXUD 2JRAA 1E8BA 1GPZA 1OJYA 4MUCA 3IU3I 5FO8C 4FXGG 5HYPA 2WIIC 1OK9A 1ZJKA 4F4OC 1G4GA 2G7IA 2EHFA 1MD8A 3R62A 3MQLA 2CKUA 3CALA 4PZ5A 3O8EB 3SW0X 1QUBA 2CG7A 3IX0A 3T5OA 1ELVA 1H2QP 2ERJA 1GKNA 2RKYA 4AYIA 3GOVA 2RL0A 1HFHA 1SS2A 4LOSA 4C16A 4J38B 1O9AA 1Q3XA 2V8EA 1H2PP 1VVDA 2LOJA 2XQWC 2O39C 1QGBA
chains in the Genus database with same CATH superfamily
4IGDA 4WJG2 1C1ZA 2KMSA 2A55A 1PPQA 2Y8SA 1TPGA 1VVCA 1TPMA 2JGWA 1FBRA 1H04P 2I2LA 1QO6A 3ZD1A 3L89M 2IZ3A 3ZLEA 2W80A 5I0QB 3KZJA 4K12A 5DN5A 4AYMA 4ZH1D 3TVJA 1OK3A 3NFPI 2QY0A 2MCZA 1SRZA 2XRBA 3FGTA 4APLA 1E5GA 1TPNA 1Z92B 4MSLA 2XWJI 3ZLDA 1MD7A 2UWNA 1H03P 1U5MA 1G4FA 2YRAA 1HCCA 1NWVA 2XWBF 2RLPA 5DN4A 4B2SA 1OK2A 2CG6A 4KKDA 3WSYA 1OJWA 2MCYA 2XRDA 4LOTA 1E88A 2EC3A 3F6KA 2B5ID 2BZMA 4JHSA 4YNXA 5JPMG 2RLQA 1LY2A 3M7PA 1OJVA 2RKZA 4B2RA 3ZRZA 1CKLA 2IZ4A 5HZPB 3VWOA 3CI0J 1OK1A 2KRIA 2Y8RA 3ZD2A 3NJAA 2YBYA 4AYDA 5HYUB 1HFIA 3EJHA 3KXVA 4DJZA 3OEDC 3RJ3D 2X2ZA 2W81A 1GKGA 3OP8A 1UOTP 3ERBA 4ONTD 4PO7A 4AYEA 1GHQB 3INBC 3GXEA 3K3TA 5HYTB 4CSYA 4A5WB 2JGXA 2ZYCA 3OXUD 2JRAA 1E8BA 1GPZA 1OJYA 4MUCA 3IU3I 5FO8C 4FXGG 5HYPA 2WIIC 1OK9A 1ZJKA 4F4OC 1G4GA 2G7IA 2EHFA 1MD8A 3R62A 3MQLA 2CKUA 3CALA 4PZ5A 3WSXA 3O8EB 3SW0X 1QUBA 2CG7A 3IX0A 3T5OA 1ELVA 1H2QP 2ERJA 2Y8TA 1RLHA 1GKNA 4N7EA 2RKYA 4AYIA 3GOVA 2RL0A 1HFHA 1SS2A 4LOSA 4C16A 4J38B 3FGRA 1O9AA 1Q3XA 4BWCA 2V8EA 1H2PP 1VVDA 2LOJA 2XQWC 4YIZA 2O39C 1QGBA
chains in the Genus database with same CATH topology
4IGDA 4WJG2 1C1ZA 2KMSA 2A55A 1PPQA 1TPGA 1VVCA 1TPMA 2JGWA 1FBRA 1H04P 1QO6A 3ZD1A 3L89M 2IZ3A 2W80A 5I0QB 3KZJA 4K12A 4AYMA 4ZH1D 3TVJA 1OK3A 3NFPI 2QY0A 2MCZA 1SRZA 2XRBA 1E5GA 1TPNA 1Z92B 2XWJI 1MD7A 2UWNA 1H03P 1U5MA 1G4FA 2YRAA 1HCCA 1NWVA 2XWBF 2RLPA 4B2SA 1OK2A 2CG6A 4KKDA 1OJWA 2MCYA 2XRDA 4LOTA 1E88A 2EC3A 2B5ID 2BZMA 4JHSA 4YNXA 5JPMG 1LY2A 2RLQA 3M7PA 1OJVA 2RKZA 4B2RA 3ZRZA 1CKLA 2IZ4A 5HZPB 1OK1A 2KRIA 3ZD2A 2YBYA 4AYDA 5HYUB 1HFIA 3EJHA 3KXVA 4DJZA 3OEDC 3RJ3D 2W81A 1GKGA 3OP8A 1UOTP 3ERBA 4ONTD 4AYEA 1GHQB 3INBC 3GXEA 5HYTB 4CSYA 4A5WB 2JGXA 3OXUD 2JRAA 1E8BA 1GPZA 1OJYA 4MUCA 3IU3I 5FO8C 4FXGG 5HYPA 2WIIC 1OK9A 1ZJKA 4F4OC 1G4GA 2G7IA 2EHFA 1MD8A 3R62A 3MQLA 2CKUA 3CALA 4PZ5A 3O8EB 3SW0X 1QUBA 2CG7A 3IX0A 3T5OA 1ELVA 1H2QP 2ERJA 1GKNA 2RKYA 4AYIA 3GOVA 2RL0A 1HFHA 1SS2A 4LOSA 4C16A 4J38B 1O9AA 1Q3XA 2V8EA 1H2PP 1VVDA 2LOJA 2XQWC 2O39C 1QGBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IGD A;  4WJG 2;  1C1Z A;  2KMS A;  2A55 A;  1PPQ A;  1TPG A;  1VVC A;  1TPM A;  2JGW A;  1FBR A;  1H04 P;  1QO6 A;  3ZD1 A;  3L89 M;  2IZ3 A;  2W80 A;  5I0Q B;  3KZJ A;  4K12 A;  4AYM A;  4ZH1 D;  3TVJ A;  1OK3 A;  3NFP I;  2QY0 A;  2MCZ A;  1SRZ A;  2XRB A;  1E5G A;  1TPN A;  1Z92 B;  2XWJ I;  1MD7 A;  2UWN A;  1H03 P;  1U5M A;  1G4F A;  2YRA A;  1HCC A;  1NWV A;  2XWB F;  2RLP A;  4B2S A;  1OK2 A;  2CG6 A;  4KKD A;  1OJW A;  2MCY A;  2XRD A;  4LOT A;  1E88 A;  2EC3 A;  2B5I D;  2BZM A;  4JHS A;  4YNX A;  5JPM G;  1LY2 A;  2RLQ A;  3M7P A;  1OJV A;  2RKZ A;  4B2R A;  3ZRZ A;  1CKL A;  2IZ4 A;  5HZP B;  1OK1 A;  2KRI A;  3ZD2 A;  2YBY A;  4AYD A;  5HYU B;  1HFI A;  3EJH A;  3KXV A;  4DJZ A;  3OED C;  3RJ3 D;  2W81 A;  1GKG A;  3OP8 A;  1UOT P;  3ERB A;  4ONT D;  4AYE A;  1GHQ B;  3INB C;  3GXE A;  5HYT B;  4CSY A;  4A5W B;  2JGX A;  3OXU D;  2JRA A;  1E8B A;  1GPZ A;  1OJY A;  4MUC A;  3IU3 I;  5FO8 C;  4FXG G;  5HYP A;  2WII C;  1OK9 A;  1ZJK A;  4F4O C;  1G4G A;  2G7I A;  2EHF A;  1MD8 A;  3R62 A;  3MQL A;  2CKU A;  3CAL A;  4PZ5 A;  3O8E B;  3SW0 X;  1QUB A;  2CG7 A;  3IX0 A;  3T5O A;  1ELV A;  1H2Q P;  2ERJ A;  1GKN A;  2RKY A;  4AYI A;  3GOV A;  2RL0 A;  1HFH A;  1SS2 A;  4LOS A;  4C16 A;  4J38 B;  1O9A A;  1Q3X A;  2V8E A;  1H2P P;  1VVD A;  2LOJ A;  2XQW C;  2O39 C;  1QGB A; 
#chains in the Genus database with same CATH topology
 4IGD A;  4WJG 2;  1C1Z A;  2KMS A;  2A55 A;  1PPQ A;  2Y8S A;  1TPG A;  1VVC A;  1TPM A;  2JGW A;  1FBR A;  1H04 P;  2I2L A;  1QO6 A;  3ZD1 A;  3L89 M;  2IZ3 A;  3ZLE A;  2W80 A;  5I0Q B;  3KZJ A;  4K12 A;  5DN5 A;  4AYM A;  4ZH1 D;  3TVJ A;  1OK3 A;  3NFP I;  2QY0 A;  2MCZ A;  1SRZ A;  2XRB A;  3FGT A;  4APL A;  1E5G A;  1TPN A;  1Z92 B;  4MSL A;  2XWJ I;  3ZLD A;  1MD7 A;  2UWN A;  1H03 P;  1U5M A;  1G4F A;  2YRA A;  1HCC A;  1NWV A;  2XWB F;  2RLP A;  5DN4 A;  4B2S A;  1OK2 A;  2CG6 A;  4KKD A;  3WSY A;  1OJW A;  2MCY A;  2XRD A;  4LOT A;  1E88 A;  2EC3 A;  3F6K A;  2B5I D;  2BZM A;  4JHS A;  4YNX A;  5JPM G;  2RLQ A;  1LY2 A;  3M7P A;  1OJV A;  2RKZ A;  4B2R A;  3ZRZ A;  1CKL A;  2IZ4 A;  5HZP B;  3VWO A;  3CI0 J;  1OK1 A;  2KRI A;  2Y8R A;  3ZD2 A;  3NJA A;  2YBY A;  4AYD A;  5HYU B;  1HFI A;  3EJH A;  3KXV A;  4DJZ A;  3OED C;  3RJ3 D;  2X2Z A;  2W81 A;  1GKG A;  3OP8 A;  1UOT P;  3ERB A;  4ONT D;  4PO7 A;  4AYE A;  1GHQ B;  3INB C;  3GXE A;  3K3T A;  5HYT B;  4CSY A;  4A5W B;  2JGX A;  2ZYC A;  3OXU D;  2JRA A;  1E8B A;  1GPZ A;  1OJY A;  4MUC A;  3IU3 I;  5FO8 C;  4FXG G;  5HYP A;  2WII C;  1OK9 A;  1ZJK A;  4F4O C;  1G4G A;  2G7I A;  2EHF A;  1MD8 A;  3R62 A;  3MQL A;  2CKU A;  3CAL A;  4PZ5 A;  3WSX A;  3O8E B;  3SW0 X;  1QUB A;  2CG7 A;  3IX0 A;  3T5O A;  1ELV A;  1H2Q P;  2ERJ A;  2Y8T A;  1RLH A;  1GKN A;  4N7E A;  2RKY A;  4AYI A;  3GOV A;  2RL0 A;  1HFH A;  1SS2 A;  4LOS A;  4C16 A;  4J38 B;  3FGR A;  1O9A A;  1Q3X A;  4BWC A;  2V8E A;  1H2P P;  1VVD A;  2LOJ A;  2XQW C;  4YIZ A;  2O39 C;  1QGB A; 
#chains in the Genus database with same CATH homology
 4IGD A;  4WJG 2;  1C1Z A;  2KMS A;  2A55 A;  1PPQ A;  1TPG A;  1VVC A;  1TPM A;  2JGW A;  1FBR A;  1H04 P;  1QO6 A;  3ZD1 A;  3L89 M;  2IZ3 A;  2W80 A;  5I0Q B;  3KZJ A;  4K12 A;  4AYM A;  4ZH1 D;  3TVJ A;  1OK3 A;  3NFP I;  2QY0 A;  2MCZ A;  1SRZ A;  2XRB A;  1E5G A;  1TPN A;  1Z92 B;  2XWJ I;  1MD7 A;  2UWN A;  1H03 P;  1U5M A;  1G4F A;  2YRA A;  1HCC A;  1NWV A;  2XWB F;  2RLP A;  4B2S A;  1OK2 A;  2CG6 A;  4KKD A;  1OJW A;  2MCY A;  2XRD A;  4LOT A;  1E88 A;  2EC3 A;  2B5I D;  2BZM A;  4JHS A;  4YNX A;  5JPM G;  1LY2 A;  2RLQ A;  3M7P A;  1OJV A;  2RKZ A;  4B2R A;  3ZRZ A;  1CKL A;  2IZ4 A;  5HZP B;  1OK1 A;  2KRI A;  3ZD2 A;  2YBY A;  4AYD A;  5HYU B;  1HFI A;  3EJH A;  3KXV A;  4DJZ A;  3OED C;  3RJ3 D;  2W81 A;  1GKG A;  3OP8 A;  1UOT P;  3ERB A;  4ONT D;  4AYE A;  1GHQ B;  3INB C;  3GXE A;  5HYT B;  4CSY A;  4A5W B;  2JGX A;  3OXU D;  2JRA A;  1E8B A;  1GPZ A;  1OJY A;  4MUC A;  3IU3 I;  5FO8 C;  4FXG G;  5HYP A;  2WII C;  1OK9 A;  1ZJK A;  4F4O C;  1G4G A;  2G7I A;  2EHF A;  1MD8 A;  3R62 A;  3MQL A;  2CKU A;  3CAL A;  4PZ5 A;  3O8E B;  3SW0 X;  1QUB A;  2CG7 A;  3IX0 A;  3T5O A;  1ELV A;  1H2Q P;  2ERJ A;  1GKN A;  2RKY A;  4AYI A;  3GOV A;  2RL0 A;  1HFH A;  1SS2 A;  4LOS A;  4C16 A;  4J38 B;  1O9A A;  1Q3X A;  2V8E A;  1H2P P;  1VVD A;  2LOJ A;  2XQW C;  2O39 C;  1QGB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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