3TVJA

Catalytic fragment of masp-2 in complex with its specific inhibitor developed by directed evolution on sgci scaffold
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
83
structure length
83
Chain Sequence
TIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCDADGFWTSSKGEKSLPVCEPVCGLSARTTGGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2.
pubmed doi rcsb
molecule keywords Mannan-binding lectin serine protease 2 A chain
molecule tags Hydrolase
source organism Homo sapiens
total genus 17
structure length 83
sequence length 83
ec nomenclature ec 3.4.21.104: Mannan-binding lectin-associated serine protease-2.
pdb deposition date 2011-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3tvjA01
2JGWA 2CG6A 4YNXA 1HFHA 3RJ3D 1GPZA 1ZJKA 2QY0A 2IZ3A 3ZRZA 2W81A 4LOSA 4F4OC 5HYPA 3ERBA 4AYDA 1SRZA 1TPNA 5I0QB 3GXEA 1G4GA 2V8EA 2XWBF 2JGXA 3GOVA 2BZMA 4IGDA 2RKZA 2KRIA 1U5MA 2YRAA 3NFPI 1H03P 4WJG2 4PZ5A 2CG7A 1GKNA 3IX0A 5HYTB 2XRDA 2EHFA 4B2RA 2IZ4A 1HFIA 1FBRA 3M7PA 2RKYA 4A5WB 2WIIC 5FO8C 3OEDC 1CKLA 4C16A 5HYUB 2CKUA 3OP8A 1TPGA 4FXGG 2MCZA 3KXVA 1E8BA 3MQLA 3O8EB 2RL0A 3KZJA 2G7IA 1G4FA 3IU3I 1E5GA 1C1ZA 4JHSA 1OJWA 1OK9A 1Z92B 3L89M 2KMSA 1H04P 4AYIA 1H2QP 1E88A 1GKGA 1MD8A 1MD7A 1H2PP 4AYEA 4ZH1D 1VVCA 2JRAA 1O9AA 1Q3XA 2XWJI 4AYMA 1HCCA 1QO6A 1QUBA 1ELVA 1SS2A 2O39C 4DJZA 1UOTP 4KKDA 4LOTA 5JPMG 2ERJA 4K12A 2MCYA 1OK3A 1VVDA 3ZD2A 1OK2A 3EJHA 2XRBA 1NWVA 2LOJA 2A55A 2XQWC 4CSYA 2RLQA 3OXUD 4J38B 1TPMA 1OK1A 2YBYA 1OJYA 3T5OA 1QGBA 2UWNA 2B5ID 2RLPA 3ZD1A 1LY2A 1OJVA 4MUCA 2EC3A 2W80A 3CALA 3TVJA 3SW0X 4ONTD 5HZPB 1GHQB 3INBC 4B2SA 1PPQA 3R62A
chains in the Genus database with same CATH superfamily
2JGWA 2CG6A 4YNXA 1HFHA 3RJ3D 1GPZA 1ZJKA 2QY0A 2IZ3A 3VWOA 2W81A 3ZRZA 4APLA 4LOSA 4F4OC 5HYPA 3ERBA 4AYDA 1SRZA 5DN4A 1TPNA 5I0QB 2Y8TA 3GXEA 1G4GA 2V8EA 2XWBF 2JGXA 3GOVA 2BZMA 4IGDA 2RKZA 2KRIA 1U5MA 2YRAA 3NFPI 1H03P 4WJG2 4PZ5A 2CG7A 1GKNA 3IX0A 5HYTB 2XRDA 2EHFA 4BWCA 4B2RA 2IZ4A 1HFIA 1FBRA 3M7PA 2RKYA 4A5WB 2WIIC 5FO8C 3OEDC 1CKLA 4C16A 4PO7A 5HYUB 2Y8RA 2CKUA 3F6KA 3OP8A 1TPGA 4FXGG 2MCZA 3KXVA 1E8BA 3MQLA 3O8EB 2RL0A 2I2LA 3KZJA 2G7IA 1G4FA 1RLHA 3IU3I 1E5GA 1C1ZA 4JHSA 1OJWA 1OK9A 1Z92B 2Y8SA 3L89M 2KMSA 1H04P 4AYIA 3FGTA 1H2QP 3K3TA 1E88A 2ZYCA 1GKGA 1MD8A 1MD7A 1H2PP 4AYEA 4ZH1D 1VVCA 2JRAA 1O9AA 1Q3XA 2XWJI 4AYMA 1HCCA 1QO6A 1QUBA 1ELVA 1SS2A 2O39C 3ZLDA 4DJZA 1UOTP 4KKDA 3NJAA 4LOTA 2ERJA 5JPMG 4K12A 2MCYA 3FGRA 1OK3A 3WSXA 1VVDA 3ZD2A 1OK2A 3EJHA 2XRBA 1NWVA 2LOJA 2A55A 2XQWC 4CSYA 2RLQA 3OXUD 4J38B 1TPMA 3CI0J 1OK1A 2YBYA 4N7EA 1OJYA 3T5OA 1QGBA 2UWNA 2B5ID 4MSLA 2RLPA 3ZD1A 1LY2A 1OJVA 4MUCA 2EC3A 2W80A 5DN5A 3CALA 3TVJA 4YIZA 3ZLEA 4ONTD 3SW0X 2X2ZA 5HZPB 1GHQB 3INBC 4B2SA 1PPQA 3R62A 3WSYA
chains in the Genus database with same CATH topology
2JGWA 2CG6A 4YNXA 1HFHA 3RJ3D 1GPZA 1ZJKA 2QY0A 2IZ3A 3ZRZA 2W81A 4LOSA 4F4OC 5HYPA 3ERBA 4AYDA 1SRZA 1TPNA 5I0QB 3GXEA 1G4GA 2V8EA 2XWBF 2JGXA 3GOVA 2BZMA 4IGDA 2RKZA 2KRIA 1U5MA 2YRAA 3NFPI 1H03P 4WJG2 4PZ5A 2CG7A 1GKNA 3IX0A 5HYTB 2XRDA 2EHFA 4B2RA 2IZ4A 1HFIA 1FBRA 3M7PA 2RKYA 4A5WB 2WIIC 5FO8C 3OEDC 1CKLA 4C16A 5HYUB 2CKUA 3OP8A 1TPGA 4FXGG 2MCZA 3KXVA 1E8BA 3MQLA 3O8EB 2RL0A 3KZJA 2G7IA 1G4FA 3IU3I 1E5GA 1C1ZA 4JHSA 1OJWA 1OK9A 1Z92B 3L89M 2KMSA 1H04P 4AYIA 1H2QP 1E88A 1GKGA 1MD8A 1MD7A 1H2PP 4AYEA 4ZH1D 1VVCA 2JRAA 1O9AA 1Q3XA 2XWJI 4AYMA 1HCCA 1QO6A 1QUBA 1ELVA 1SS2A 2O39C 4DJZA 1UOTP 4KKDA 4LOTA 5JPMG 2ERJA 4K12A 2MCYA 1OK3A 1VVDA 3ZD2A 1OK2A 3EJHA 2XRBA 1NWVA 2LOJA 2A55A 2XQWC 4CSYA 2RLQA 3OXUD 4J38B 1TPMA 1OK1A 2YBYA 1OJYA 3T5OA 1QGBA 2UWNA 2B5ID 2RLPA 3ZD1A 1LY2A 1OJVA 4MUCA 2EC3A 2W80A 3CALA 3TVJA 3SW0X 4ONTD 5HZPB 1GHQB 3INBC 4B2SA 1PPQA 3R62A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JGW A;  2CG6 A;  4YNX A;  1HFH A;  3RJ3 D;  1GPZ A;  1ZJK A;  2QY0 A;  2IZ3 A;  3ZRZ A;  2W81 A;  4LOS A;  4F4O C;  5HYP A;  3ERB A;  4AYD A;  1SRZ A;  1TPN A;  5I0Q B;  3GXE A;  1G4G A;  2V8E A;  2XWB F;  2JGX A;  3GOV A;  2BZM A;  4IGD A;  2RKZ A;  2KRI A;  1U5M A;  2YRA A;  3NFP I;  1H03 P;  4WJG 2;  4PZ5 A;  2CG7 A;  1GKN A;  3IX0 A;  5HYT B;  2XRD A;  2EHF A;  4B2R A;  2IZ4 A;  1HFI A;  1FBR A;  3M7P A;  2RKY A;  4A5W B;  2WII C;  5FO8 C;  3OED C;  1CKL A;  4C16 A;  5HYU B;  2CKU A;  3OP8 A;  1TPG A;  4FXG G;  2MCZ A;  3KXV A;  1E8B A;  3MQL A;  3O8E B;  2RL0 A;  3KZJ A;  2G7I A;  1G4F A;  3IU3 I;  1E5G A;  1C1Z A;  4JHS A;  1OJW A;  1OK9 A;  1Z92 B;  3L89 M;  2KMS A;  1H04 P;  4AYI A;  1H2Q P;  1E88 A;  1GKG A;  1MD8 A;  1MD7 A;  1H2P P;  4AYE A;  4ZH1 D;  1VVC A;  2JRA A;  1O9A A;  1Q3X A;  2XWJ I;  4AYM A;  1HCC A;  1QO6 A;  1QUB A;  1ELV A;  1SS2 A;  2O39 C;  4DJZ A;  1UOT P;  4KKD A;  4LOT A;  5JPM G;  2ERJ A;  4K12 A;  2MCY A;  1OK3 A;  1VVD A;  3ZD2 A;  1OK2 A;  3EJH A;  2XRB A;  1NWV A;  2LOJ A;  2A55 A;  2XQW C;  4CSY A;  2RLQ A;  3OXU D;  4J38 B;  1TPM A;  1OK1 A;  2YBY A;  1OJY A;  3T5O A;  1QGB A;  2UWN A;  2B5I D;  2RLP A;  3ZD1 A;  1LY2 A;  1OJV A;  4MUC A;  2EC3 A;  2W80 A;  3CAL A;  3TVJ A;  3SW0 X;  4ONT D;  5HZP B;  1GHQ B;  3INB C;  4B2S A;  1PPQ A;  3R62 A; 
#chains in the Genus database with same CATH topology
 2JGW A;  2CG6 A;  4YNX A;  1HFH A;  3RJ3 D;  1GPZ A;  1ZJK A;  2QY0 A;  2IZ3 A;  3VWO A;  2W81 A;  3ZRZ A;  4APL A;  4LOS A;  4F4O C;  5HYP A;  3ERB A;  4AYD A;  1SRZ A;  5DN4 A;  1TPN A;  5I0Q B;  2Y8T A;  3GXE A;  1G4G A;  2V8E A;  2XWB F;  2JGX A;  3GOV A;  2BZM A;  4IGD A;  2RKZ A;  2KRI A;  1U5M A;  2YRA A;  3NFP I;  1H03 P;  4WJG 2;  4PZ5 A;  2CG7 A;  1GKN A;  3IX0 A;  5HYT B;  2XRD A;  2EHF A;  4BWC A;  4B2R A;  2IZ4 A;  1HFI A;  1FBR A;  3M7P A;  2RKY A;  4A5W B;  2WII C;  5FO8 C;  3OED C;  1CKL A;  4C16 A;  4PO7 A;  5HYU B;  2Y8R A;  2CKU A;  3F6K A;  3OP8 A;  1TPG A;  4FXG G;  2MCZ A;  3KXV A;  1E8B A;  3MQL A;  3O8E B;  2RL0 A;  2I2L A;  3KZJ A;  2G7I A;  1G4F A;  1RLH A;  3IU3 I;  1E5G A;  1C1Z A;  4JHS A;  1OJW A;  1OK9 A;  1Z92 B;  2Y8S A;  3L89 M;  2KMS A;  1H04 P;  4AYI A;  3FGT A;  1H2Q P;  3K3T A;  1E88 A;  2ZYC A;  1GKG A;  1MD8 A;  1MD7 A;  1H2P P;  4AYE A;  4ZH1 D;  1VVC A;  2JRA A;  1O9A A;  1Q3X A;  2XWJ I;  4AYM A;  1HCC A;  1QO6 A;  1QUB A;  1ELV A;  1SS2 A;  2O39 C;  3ZLD A;  4DJZ A;  1UOT P;  4KKD A;  3NJA A;  4LOT A;  2ERJ A;  5JPM G;  4K12 A;  2MCY A;  3FGR A;  1OK3 A;  3WSX A;  1VVD A;  3ZD2 A;  1OK2 A;  3EJH A;  2XRB A;  1NWV A;  2LOJ A;  2A55 A;  2XQW C;  4CSY A;  2RLQ A;  3OXU D;  4J38 B;  1TPM A;  3CI0 J;  1OK1 A;  2YBY A;  4N7E A;  1OJY A;  3T5O A;  1QGB A;  2UWN A;  2B5I D;  4MSL A;  2RLP A;  3ZD1 A;  1LY2 A;  1OJV A;  4MUC A;  2EC3 A;  2W80 A;  5DN5 A;  3CAL A;  3TVJ A;  4YIZ A;  3ZLE A;  4ONT D;  3SW0 X;  2X2Z A;  5HZP B;  1GHQ B;  3INB C;  4B2S A;  1PPQ A;  3R62 A;  3WSY A; 
#chains in the Genus database with same CATH homology
 2JGW A;  2CG6 A;  4YNX A;  1HFH A;  3RJ3 D;  1GPZ A;  1ZJK A;  2QY0 A;  2IZ3 A;  3ZRZ A;  2W81 A;  4LOS A;  4F4O C;  5HYP A;  3ERB A;  4AYD A;  1SRZ A;  1TPN A;  5I0Q B;  3GXE A;  1G4G A;  2V8E A;  2XWB F;  2JGX A;  3GOV A;  2BZM A;  4IGD A;  2RKZ A;  2KRI A;  1U5M A;  2YRA A;  3NFP I;  1H03 P;  4WJG 2;  4PZ5 A;  2CG7 A;  1GKN A;  3IX0 A;  5HYT B;  2XRD A;  2EHF A;  4B2R A;  2IZ4 A;  1HFI A;  1FBR A;  3M7P A;  2RKY A;  4A5W B;  2WII C;  5FO8 C;  3OED C;  1CKL A;  4C16 A;  5HYU B;  2CKU A;  3OP8 A;  1TPG A;  4FXG G;  2MCZ A;  3KXV A;  1E8B A;  3MQL A;  3O8E B;  2RL0 A;  3KZJ A;  2G7I A;  1G4F A;  3IU3 I;  1E5G A;  1C1Z A;  4JHS A;  1OJW A;  1OK9 A;  1Z92 B;  3L89 M;  2KMS A;  1H04 P;  4AYI A;  1H2Q P;  1E88 A;  1GKG A;  1MD8 A;  1MD7 A;  1H2P P;  4AYE A;  4ZH1 D;  1VVC A;  2JRA A;  1O9A A;  1Q3X A;  2XWJ I;  4AYM A;  1HCC A;  1QO6 A;  1QUB A;  1ELV A;  1SS2 A;  2O39 C;  4DJZ A;  1UOT P;  4KKD A;  4LOT A;  5JPM G;  2ERJ A;  4K12 A;  2MCY A;  1OK3 A;  1VVD A;  3ZD2 A;  1OK2 A;  3EJH A;  2XRB A;  1NWV A;  2LOJ A;  2A55 A;  2XQW C;  4CSY A;  2RLQ A;  3OXU D;  4J38 B;  1TPM A;  1OK1 A;  2YBY A;  1OJY A;  3T5O A;  1QGB A;  2UWN A;  2B5I D;  2RLP A;  3ZD1 A;  1LY2 A;  1OJV A;  4MUC A;  2EC3 A;  2W80 A;  3CAL A;  3TVJ A;  3SW0 X;  4ONT D;  5HZP B;  1GHQ B;  3INB C;  4B2S A;  1PPQ A;  3R62 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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