3WSXA

Sorla vps10p domain in ligand-free form
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
663
structure length
606
Chain Sequence
PIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINMRSVITFDKGGTWEFLQAPGCSLHLAQMPILSKESAPGLIIATGSVGKKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for amyloidogenic peptide recognition by sorLA
doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Sortilin-related receptor
total genus 134
structure length 606
sequence length 663
ec nomenclature
pdb deposition date 2014-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15901 Sortilin_C Sortilin, neurotensin receptor 3, C-terminal
A PF15902 Sortilin-Vps10 Sortilin, neurotensin receptor 3,
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.90 Mainly Beta Ribbon Complement Module; domain 1 Complement Module; domain 1 3wsxA03
3F6KA 4N7EA 3WSYA 3WSXA 4MSLA 4PO7A
chains in the Genus database with same CATH superfamily
1HFHA 1GKNA 2XRDA 3IU3I 2UWNA 2W81A 4PO7A 3O8EB 3ZLDA 2XWBF 2EHFA 2RKYA 2KRIA 4F4OC 2ERJA 4N7EA 2KMSA 2O39C 2Y8SA 1TPNA 2JGXA 2RKZA 2LOJA 1MD7A 4K12A 3IX0A 5FO8C 1OJWA 1QO6A 2RLPA 1TPGA 1NWVA 2Y8TA 1GKGA 2RL0A 1OK3A 5DN4A 3EJHA 1Q3XA 2RLQA 4KKDA 4YIZA 2XWJI 3RJ3D 2EC3A 3KXVA 1GHQB 1O9AA 2MCZA 1VVCA 4AYEA 3T5OA 3ZLEA 2G7IA 2B5ID 1SRZA 5HZPB 4C16A 3NJAA 2WIIC 4MSLA 2JGWA 4J38B 4ZH1D 5HYPA 4ONTD 3GOVA 1OK2A 1C1ZA 2V8EA 2CG6A 1MD8A 2X2ZA 2YRAA 3ZRZA 4BWCA 2XQWC 1ELVA 3K3TA 1E8BA 1FBRA 4AYDA 3INBC 2W80A 1GPZA 4AYMA 4IGDA 1OK9A 3GXEA 1TPMA 1SS2A 2I2LA 3CI0J 4APLA 1Z92B 2MCYA 1G4GA 1LY2A 4A5WB 2A55A 4MUCA 1CKLA 1U5MA 2CKUA 1E88A 2Y8RA 5DN5A 3KZJA 5HYTB 2BZMA 2YBYA 2ZYCA 1OJVA 3R62A 4FXGG 4B2SA 1PPQA 3M7PA 4LOTA 1HCCA 1OK1A 3ZD1A 1H03P 4B2RA 4DJZA 2CG7A 3ERBA 1H04P 4CSYA 1VVDA 1H2PP 4WJG2 3L89M 5I0QB 3SW0X 2IZ4A 3MQLA 1H2QP 3NFPI 1QGBA 2XRBA 1ZJKA 2JRAA 3CALA 3ZD2A 3OP8A 3F6KA 3WSYA 4LOSA 3FGTA 4PZ5A 1OJYA 3TVJA 2IZ3A 3FGRA 2QY0A 3OEDC 1HFIA 3WSXA 1QUBA 1RLHA 4JHSA 5JPMG 1E5GA 3OXUD 4YNXA 5HYUB 4AYIA 3VWOA 1G4FA 1UOTP
chains in the Genus database with same CATH topology
2I2LA 4APLA 4PO7A 3ZLDA 3F6KA 4N7EA 3WSYA 3ZLEA 3FGTA 3NJAA 4MSLA 2Y8SA 2Y8RA 3FGRA 2X2ZA 4BWCA 2Y8TA 3WSXA 4YIZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F6K A;  4N7E A;  3WSY A;  3WSX A;  4MSL A;  4PO7 A; 
#chains in the Genus database with same CATH topology
 1HFH A;  1GKN A;  2XRD A;  3IU3 I;  2UWN A;  2W81 A;  4PO7 A;  3O8E B;  3ZLD A;  2XWB F;  2EHF A;  2RKY A;  2KRI A;  4F4O C;  2ERJ A;  4N7E A;  2KMS A;  2O39 C;  2Y8S A;  1TPN A;  2JGX A;  2RKZ A;  2LOJ A;  1MD7 A;  4K12 A;  3IX0 A;  5FO8 C;  1OJW A;  1QO6 A;  2RLP A;  1TPG A;  1NWV A;  2Y8T A;  1GKG A;  2RL0 A;  1OK3 A;  5DN4 A;  3EJH A;  1Q3X A;  2RLQ A;  4KKD A;  4YIZ A;  2XWJ I;  3RJ3 D;  2EC3 A;  3KXV A;  1GHQ B;  1O9A A;  2MCZ A;  1VVC A;  4AYE A;  3T5O A;  3ZLE A;  2G7I A;  2B5I D;  1SRZ A;  5HZP B;  4C16 A;  3NJA A;  2WII C;  4MSL A;  2JGW A;  4J38 B;  4ZH1 D;  5HYP A;  4ONT D;  3GOV A;  1OK2 A;  1C1Z A;  2V8E A;  2CG6 A;  1MD8 A;  2X2Z A;  2YRA A;  3ZRZ A;  4BWC A;  2XQW C;  1ELV A;  3K3T A;  1E8B A;  1FBR A;  4AYD A;  3INB C;  2W80 A;  1GPZ A;  4AYM A;  4IGD A;  1OK9 A;  3GXE A;  1TPM A;  1SS2 A;  2I2L A;  3CI0 J;  4APL A;  1Z92 B;  2MCY A;  1G4G A;  1LY2 A;  4A5W B;  2A55 A;  4MUC A;  1CKL A;  1U5M A;  2CKU A;  1E88 A;  2Y8R A;  5DN5 A;  3KZJ A;  5HYT B;  2BZM A;  2YBY A;  2ZYC A;  1OJV A;  3R62 A;  4FXG G;  4B2S A;  1PPQ A;  3M7P A;  4LOT A;  1HCC A;  1OK1 A;  3ZD1 A;  1H03 P;  4B2R A;  4DJZ A;  2CG7 A;  3ERB A;  1H04 P;  4CSY A;  1VVD A;  1H2P P;  4WJG 2;  3L89 M;  5I0Q B;  3SW0 X;  2IZ4 A;  3MQL A;  1H2Q P;  3NFP I;  1QGB A;  2XRB A;  1ZJK A;  2JRA A;  3CAL A;  3ZD2 A;  3OP8 A;  3F6K A;  3WSY A;  4LOS A;  3FGT A;  4PZ5 A;  1OJY A;  3TVJ A;  2IZ3 A;  3FGR A;  2QY0 A;  3OED C;  1HFI A;  3WSX A;  1QUB A;  1RLH A;  4JHS A;  5JPM G;  1E5G A;  3OXU D;  4YNX A;  5HYU B;  4AYI A;  3VWO A;  1G4F A;  1UOT P; 
#chains in the Genus database with same CATH homology
 2I2L A;  4APL A;  4PO7 A;  3ZLD A;  3F6K A;  4N7E A;  3WSY A;  3ZLE A;  3FGT A;  3NJA A;  4MSL A;  2Y8S A;  2Y8R A;  3FGR A;  2X2Z A;  4BWC A;  2Y8T A;  3WSX A;  4YIZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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