3WSYA

Sorla vps10p domain in complex with its own propeptide fragment
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
668
structure length
662
Chain Sequence
QPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGPPVPCPSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for amyloidogenic peptide recognition by sorLA
doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Sortilin-related receptor
total genus 144
structure length 662
sequence length 668
ec nomenclature
pdb deposition date 2014-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15901 Sortilin_C Sortilin, neurotensin receptor 3, C-terminal
A PF15902 Sortilin-Vps10 Sortilin, neurotensin receptor 3,
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.90 Mainly Beta Ribbon Complement Module; domain 1 Complement Module; domain 1 3wsyA03
3F6KA 3WSXA 4N7EA 3WSYA 4PO7A 4MSLA
chains in the Genus database with same CATH superfamily
2B5ID 3WSXA 1VVCA 4JHSA 2RKYA 3CALA 3ZLDA 2KMSA 2YRAA 5DN4A 4BWCA 2CG7A 5DN5A 2RLPA 1OK2A 3NFPI 4AYEA 2QY0A 3EJHA 4A5WB 1RLHA 3ERBA 3GOVA 4K12A 1Z92B 2JGWA 4DJZA 3SW0X 5HYUB 1SS2A 5HYTB 2IZ3A 3IX0A 1H04P 4WJG2 2G7IA 3KXVA 3MQLA 3R62A 3TVJA 1ELVA 2XWBF 3T5OA 3FGRA 2V8EA 2X2ZA 2JGXA 2I2LA 3CI0J 4IGDA 3GXEA 5I0QB 4C16A 4MUCA 4APLA 2LOJA 2O39C 5HZPB 1TPMA 3ZRZA 4CSYA 3ZLEA 1OK3A 2CG6A 1LY2A 1OJWA 3WSYA 1HCCA 1FBRA 1G4FA 2XWJI 2CKUA 1QUBA 2XRBA 2RKZA 1C1ZA 3KZJA 4PO7A 4YIZA 1GKNA 1OK1A 2UWNA 1GHQB 1QGBA 4KKDA 2ERJA 1CKLA 2Y8RA 2RLQA 3RJ3D 4FXGG 4AYMA 2EC3A 2Y8TA 3INBC 3VWOA 4AYDA 1HFIA 4LOTA 4PZ5A 3OXUD 5JPMG 2A55A 3L89M 1SRZA 1PPQA 2RL0A 2W81A 2Y8SA 1H03P 3F6KA 1TPGA 4MSLA 5FO8C 2KRIA 2IZ4A 4ZH1D 4F4OC 4ONTD 2W80A 5HYPA 1ZJKA 2EHFA 3IU3I 1HFHA 4B2RA 3NJAA 1OJYA 3K3TA 1E8BA 4YNXA 1VVDA 2JRAA 1H2PP 3ZD2A 4B2SA 2WIIC 4LOSA 4AYIA 1MD8A 1QO6A 2YBYA 1GKGA 1UOTP 1OJVA 1MD7A 3OP8A 1G4GA 3FGTA 4N7EA 1H2QP 2BZMA 4J38B 2MCYA 1TPNA 1E5GA 3M7PA 1GPZA 1U5MA 2MCZA 1OK9A 2XQWC 2ZYCA 3OEDC 2XRDA 3ZD1A 1NWVA 1O9AA 1E88A 1Q3XA 3O8EB
chains in the Genus database with same CATH topology
3FGRA 2X2ZA 3WSXA 2I2LA 3ZLDA 4BWCA 4APLA 2Y8SA 3F6KA 3FGTA 4N7EA 3ZLEA 3WSYA 4MSLA 4PO7A 4YIZA 2Y8RA 3NJAA 2Y8TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F6K A;  3WSX A;  4N7E A;  3WSY A;  4PO7 A;  4MSL A; 
#chains in the Genus database with same CATH topology
 2B5I D;  3WSX A;  1VVC A;  4JHS A;  2RKY A;  3CAL A;  3ZLD A;  2KMS A;  2YRA A;  5DN4 A;  4BWC A;  2CG7 A;  5DN5 A;  2RLP A;  1OK2 A;  3NFP I;  4AYE A;  2QY0 A;  3EJH A;  4A5W B;  1RLH A;  3ERB A;  3GOV A;  4K12 A;  1Z92 B;  2JGW A;  4DJZ A;  3SW0 X;  5HYU B;  1SS2 A;  5HYT B;  2IZ3 A;  3IX0 A;  1H04 P;  4WJG 2;  2G7I A;  3KXV A;  3MQL A;  3R62 A;  3TVJ A;  1ELV A;  2XWB F;  3T5O A;  3FGR A;  2V8E A;  2X2Z A;  2JGX A;  2I2L A;  3CI0 J;  4IGD A;  3GXE A;  5I0Q B;  4C16 A;  4MUC A;  4APL A;  2LOJ A;  2O39 C;  5HZP B;  1TPM A;  3ZRZ A;  4CSY A;  3ZLE A;  1OK3 A;  2CG6 A;  1LY2 A;  1OJW A;  3WSY A;  1HCC A;  1FBR A;  1G4F A;  2XWJ I;  2CKU A;  1QUB A;  2XRB A;  2RKZ A;  1C1Z A;  3KZJ A;  4PO7 A;  4YIZ A;  1GKN A;  1OK1 A;  2UWN A;  1GHQ B;  1QGB A;  4KKD A;  2ERJ A;  1CKL A;  2Y8R A;  2RLQ A;  3RJ3 D;  4FXG G;  4AYM A;  2EC3 A;  2Y8T A;  3INB C;  3VWO A;  4AYD A;  1HFI A;  4LOT A;  4PZ5 A;  3OXU D;  5JPM G;  2A55 A;  3L89 M;  1SRZ A;  1PPQ A;  2RL0 A;  2W81 A;  2Y8S A;  1H03 P;  3F6K A;  1TPG A;  4MSL A;  5FO8 C;  2KRI A;  2IZ4 A;  4ZH1 D;  4F4O C;  4ONT D;  2W80 A;  5HYP A;  1ZJK A;  2EHF A;  3IU3 I;  1HFH A;  4B2R A;  3NJA A;  1OJY A;  3K3T A;  1E8B A;  4YNX A;  1VVD A;  2JRA A;  1H2P P;  3ZD2 A;  4B2S A;  2WII C;  4LOS A;  4AYI A;  1MD8 A;  1QO6 A;  2YBY A;  1GKG A;  1UOT P;  1OJV A;  1MD7 A;  3OP8 A;  1G4G A;  3FGT A;  4N7E A;  1H2Q P;  2BZM A;  4J38 B;  2MCY A;  1TPN A;  1E5G A;  3M7P A;  1GPZ A;  1U5M A;  2MCZ A;  1OK9 A;  2XQW C;  2ZYC A;  3OED C;  2XRD A;  3ZD1 A;  1NWV A;  1O9A A;  1E88 A;  1Q3X A;  3O8E B; 
#chains in the Genus database with same CATH homology
 3FGR A;  2X2Z A;  3WSX A;  2I2L A;  3ZLD A;  4BWC A;  4APL A;  2Y8S A;  3F6K A;  3FGT A;  4N7E A;  3ZLE A;  3WSY A;  4MSL A;  4PO7 A;  4YIZ A;  2Y8R A;  3NJA A;  2Y8T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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