3WSYA

Sorla vps10p domain in complex with its own propeptide fragment
Total Genus 144
100200300400500600020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
668
structure length
662
Chain Sequence
QPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGPPVPCPSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCP
100200300400500600600500400300200100
020406080100120140Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Protein binding
source organism Homo sapiens
publication title Structural basis for amyloidogenic peptide recognition by sorLA
doi rcsb
molecule keywords Sortilin-related receptor
total genus 144
structure length 662
sequence length 668
ec nomenclature
pdb deposition date 2014-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15901 Sortilin_C Sortilin, neurotensin receptor 3, C-terminal
A PF15902 Sortilin-Vps10 Sortilin, neurotensin receptor 3,
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.90 Mainly Beta Ribbon Complement Module; domain 1 Complement Module; domain 1 3wsyA03
4MSLA 3WSYA 3F6KA 4N7EA 3WSXA 4PO7A
chains in the Genus database with same CATH superfamily
3OP8A 3ZLEA 4ONTD 4CSYA 4AYIA 3OEDC 2I2LA 3FGTA 4AYMA 4LOTA 1QGBA 1U5MA 2W80A 3NFPI 3GXEA 4WJG2 3IX0A 2RLQA 1ELVA 3OXUD 5HYPA 2CKUA 2IZ3A 1E88A 1G4GA 2EC3A 3NJAA 4LOSA 4F4OC 1C1ZA 2KRIA 4N7EA 2V8EA 1QUBA 5HYUB 2WIIC 2ERJA 1H2PP 1VVCA 1H2QP 2UWNA 1RLHA 1SS2A 4APLA 5HYTB 2XWJI 3ZD2A 2RL0A 1CKLA 1NWVA 3SW0X 2RLPA 1GKNA 1MD8A 2KMSA 1TPMA 4J38B 1VVDA 5HZPB 1OJYA 4IGDA 4PZ5A 2B5ID 3K3TA 2Y8RA 4MSLA 2YRAA 2O39C 4AYEA 1GHQB 3MQLA 2CG6A 1OK2A 4ZH1D 2Y8SA 3ZLDA 5DN5A 3CALA 4MUCA 2EHFA 2XRDA 1O9AA 2XWBF 1GPZA 2ZYCA 5JPMG 1Q3XA 2JGWA 1FBRA 5I0QB 1TPNA 4BWCA 2IZ4A 4AYDA 2YBYA 2RKYA 4YNXA 4KKDA 1OK3A 3IU3I 2XQWC 1TPGA 3ZRZA 4FXGG 1UOTP 1OJVA 3O8EB 4B2RA 2RKZA 3INBC 4JHSA 2BZMA 4DJZA 2LOJA 1QO6A 1Z92B 2MCZA 3RJ3D 1SRZA 3GOVA 2CG7A 3F6KA 3M7PA 3VWOA 4K12A 3WSXA 1LY2A 3KXVA 3ZD1A 1GKGA 4YIZA 1OJWA 3EJHA 5FO8C 3WSYA 3KZJA 2Y8TA 3T5OA 1PPQA 4C16A 3TVJA 1H04P 4A5WB 1HFHA 2X2ZA 3CI0J 4B2SA 1ZJKA 1H03P 2XRBA 2W81A 2G7IA 2MCYA 1E8BA 3L89M 1HFIA 3ERBA 2JRAA 3R62A 1G4FA 1E5GA 1HCCA 5DN4A 1OK9A 2QY0A 1OK1A 1MD7A 2JGXA 2A55A 3FGRA 4PO7A
chains in the Genus database with same CATH topology
4APLA 3ZLEA 4BWCA 4YIZA 3WSYA 2Y8TA 2I2LA 3FGTA 2X2ZA 2Y8RA 4MSLA 3NJAA 4N7EA 2Y8SA 3ZLDA 3F6KA 3WSXA 3FGRA 4PO7A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4MSL A;  3WSY A;  3F6K A;  4N7E A;  3WSX A;  4PO7 A; 
#chains in the Genus database with same CATH topology
 3OP8 A;  3ZLE A;  4ONT D;  4CSY A;  4AYI A;  3OED C;  2I2L A;  3FGT A;  4AYM A;  4LOT A;  1QGB A;  1U5M A;  2W80 A;  3NFP I;  3GXE A;  4WJG 2;  3IX0 A;  2RLQ A;  1ELV A;  3OXU D;  5HYP A;  2CKU A;  2IZ3 A;  1E88 A;  1G4G A;  2EC3 A;  3NJA A;  4LOS A;  4F4O C;  1C1Z A;  2KRI A;  4N7E A;  2V8E A;  1QUB A;  5HYU B;  2WII C;  2ERJ A;  1H2P P;  1VVC A;  1H2Q P;  2UWN A;  1RLH A;  1SS2 A;  4APL A;  5HYT B;  2XWJ I;  3ZD2 A;  2RL0 A;  1CKL A;  1NWV A;  3SW0 X;  2RLP A;  1GKN A;  1MD8 A;  2KMS A;  1TPM A;  4J38 B;  1VVD A;  5HZP B;  1OJY A;  4IGD A;  4PZ5 A;  2B5I D;  3K3T A;  2Y8R A;  4MSL A;  2YRA A;  2O39 C;  4AYE A;  1GHQ B;  3MQL A;  2CG6 A;  1OK2 A;  4ZH1 D;  2Y8S A;  3ZLD A;  5DN5 A;  3CAL A;  4MUC A;  2EHF A;  2XRD A;  1O9A A;  2XWB F;  1GPZ A;  2ZYC A;  5JPM G;  1Q3X A;  2JGW A;  1FBR A;  5I0Q B;  1TPN A;  4BWC A;  2IZ4 A;  4AYD A;  2YBY A;  2RKY A;  4YNX A;  4KKD A;  1OK3 A;  3IU3 I;  2XQW C;  1TPG A;  3ZRZ A;  4FXG G;  1UOT P;  1OJV A;  3O8E B;  4B2R A;  2RKZ A;  3INB C;  4JHS A;  2BZM A;  4DJZ A;  2LOJ A;  1QO6 A;  1Z92 B;  2MCZ A;  3RJ3 D;  1SRZ A;  3GOV A;  2CG7 A;  3F6K A;  3M7P A;  3VWO A;  4K12 A;  3WSX A;  1LY2 A;  3KXV A;  3ZD1 A;  1GKG A;  4YIZ A;  1OJW A;  3EJH A;  5FO8 C;  3WSY A;  3KZJ A;  2Y8T A;  3T5O A;  1PPQ A;  4C16 A;  3TVJ A;  1H04 P;  4A5W B;  1HFH A;  2X2Z A;  3CI0 J;  4B2S A;  1ZJK A;  1H03 P;  2XRB A;  2W81 A;  2G7I A;  2MCY A;  1E8B A;  3L89 M;  1HFI A;  3ERB A;  2JRA A;  3R62 A;  1G4F A;  1E5G A;  1HCC A;  5DN4 A;  1OK9 A;  2QY0 A;  1OK1 A;  1MD7 A;  2JGX A;  2A55 A;  3FGR A;  4PO7 A; 
#chains in the Genus database with same CATH homology
 4APL A;  3ZLE A;  4BWC A;  4YIZ A;  3WSY A;  2Y8T A;  2I2L A;  3FGT A;  2X2Z A;  2Y8R A;  4MSL A;  3NJA A;  4N7E A;  2Y8S A;  3ZLD A;  3F6K A;  3WSX A;  3FGR A;  4PO7 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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