3WSYA

Sorla vps10p domain in complex with its own propeptide fragment
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
668
structure length
662
Chain Sequence
QPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGPPVPCPSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for amyloidogenic peptide recognition by sorLA
doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Sortilin-related receptor
total genus 144
structure length 662
sequence length 668
ec nomenclature
pdb deposition date 2014-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15901 Sortilin_C Sortilin, neurotensin receptor 3, C-terminal
A PF15902 Sortilin-Vps10 Sortilin, neurotensin receptor 3,
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.90 Mainly Beta Ribbon Complement Module; domain 1 Complement Module; domain 1 3wsyA03
4MSLA 4PO7A 3WSXA 3F6KA 4N7EA 3WSYA
chains in the Genus database with same CATH superfamily
4AYMA 3ZRZA 2Y8SA 1NWVA 2RLQA 2A55A 1OJYA 2MCZA 4B2SA 3INBC 4LOSA 3OXUD 2Y8TA 5DN5A 3NFPI 2XRDA 1QO6A 1U5MA 2KMSA 2XWBF 4N7EA 5HYUB 1GKNA 3WSYA 3GOVA 3KZJA 1Z92B 3NJAA 3L89M 1H03P 1Q3XA 2RLPA 4BWCA 4CSYA 5I0QB 1HFHA 5HYTB 3ZD1A 2ZYCA 5HYPA 1OK1A 4MSLA 2O39C 2XRBA 1FBRA 1QGBA 1OJVA 1H2PP 4AYDA 3ZD2A 3KXVA 1VVCA 3CI0J 2RL0A 2JRAA 4JHSA 3VWOA 4AYIA 2CG6A 3FGTA 4C16A 3OP8A 3M7PA 1G4FA 1H2QP 4DJZA 2EHFA 1OK9A 2RKZA 3O8EB 2LOJA 4PO7A 3EJHA 2QY0A 1OK3A 2W81A 2ERJA 1OJWA 1VVDA 3IX0A 1GPZA 2V8EA 2I2LA 4J38B 2JGXA 2X2ZA 4YIZA 2YBYA 4ONTD 1GHQB 4IGDA 4B2RA 2JGWA 1HCCA 1C1ZA 1PPQA 1MD7A 1H04P 5DN4A 3FGRA 4K12A 5HZPB 2IZ3A 2B5ID 2CKUA 4PZ5A 1TPGA 5JPMG 4A5WB 2MCYA 3R62A 3GXEA 3CALA 1SS2A 2G7IA 4YNXA 2Y8RA 1HFIA 3ZLDA 3MQLA 1QUBA 3SW0X 2XQWC 2XWJI 4AYEA 4WJG2 4FXGG 1OK2A 1SRZA 3T5OA 3ZLEA 1GKGA 1G4GA 3RJ3D 1ELVA 1TPMA 2BZMA 2IZ4A 4APLA 1LY2A 1CKLA 2YRAA 5FO8C 2RKYA 1TPNA 1UOTP 2KRIA 1E88A 2W80A 2CG7A 2UWNA 1ZJKA 1MD8A 4KKDA 3K3TA 4ZH1D 1RLHA 3ERBA 4F4OC 3OEDC 4MUCA 3IU3I 3WSXA 1E8BA 4LOTA 3F6KA 2WIIC 2EC3A 1O9AA 3TVJA 1E5GA
chains in the Genus database with same CATH topology
4MSLA 2X2ZA 4YIZA 3ZLEA 2Y8SA 4APLA 2Y8TA 4N7EA 3FGRA 3WSYA 3FGTA 3NJAA 4BWCA 4PO7A 2Y8RA 3WSXA 3F6KA 3ZLDA 2I2LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MSL A;  4PO7 A;  3WSX A;  3F6K A;  4N7E A;  3WSY A; 
#chains in the Genus database with same CATH topology
 4AYM A;  3ZRZ A;  2Y8S A;  1NWV A;  2RLQ A;  2A55 A;  1OJY A;  2MCZ A;  4B2S A;  3INB C;  4LOS A;  3OXU D;  2Y8T A;  5DN5 A;  3NFP I;  2XRD A;  1QO6 A;  1U5M A;  2KMS A;  2XWB F;  4N7E A;  5HYU B;  1GKN A;  3WSY A;  3GOV A;  3KZJ A;  1Z92 B;  3NJA A;  3L89 M;  1H03 P;  1Q3X A;  2RLP A;  4BWC A;  4CSY A;  5I0Q B;  1HFH A;  5HYT B;  3ZD1 A;  2ZYC A;  5HYP A;  1OK1 A;  4MSL A;  2O39 C;  2XRB A;  1FBR A;  1QGB A;  1OJV A;  1H2P P;  4AYD A;  3ZD2 A;  3KXV A;  1VVC A;  3CI0 J;  2RL0 A;  2JRA A;  4JHS A;  3VWO A;  4AYI A;  2CG6 A;  3FGT A;  4C16 A;  3OP8 A;  3M7P A;  1G4F A;  1H2Q P;  4DJZ A;  2EHF A;  1OK9 A;  2RKZ A;  3O8E B;  2LOJ A;  4PO7 A;  3EJH A;  2QY0 A;  1OK3 A;  2W81 A;  2ERJ A;  1OJW A;  1VVD A;  3IX0 A;  1GPZ A;  2V8E A;  2I2L A;  4J38 B;  2JGX A;  2X2Z A;  4YIZ A;  2YBY A;  4ONT D;  1GHQ B;  4IGD A;  4B2R A;  2JGW A;  1HCC A;  1C1Z A;  1PPQ A;  1MD7 A;  1H04 P;  5DN4 A;  3FGR A;  4K12 A;  5HZP B;  2IZ3 A;  2B5I D;  2CKU A;  4PZ5 A;  1TPG A;  5JPM G;  4A5W B;  2MCY A;  3R62 A;  3GXE A;  3CAL A;  1SS2 A;  2G7I A;  4YNX A;  2Y8R A;  1HFI A;  3ZLD A;  3MQL A;  1QUB A;  3SW0 X;  2XQW C;  2XWJ I;  4AYE A;  4WJG 2;  4FXG G;  1OK2 A;  1SRZ A;  3T5O A;  3ZLE A;  1GKG A;  1G4G A;  3RJ3 D;  1ELV A;  1TPM A;  2BZM A;  2IZ4 A;  4APL A;  1LY2 A;  1CKL A;  2YRA A;  5FO8 C;  2RKY A;  1TPN A;  1UOT P;  2KRI A;  1E88 A;  2W80 A;  2CG7 A;  2UWN A;  1ZJK A;  1MD8 A;  4KKD A;  3K3T A;  4ZH1 D;  1RLH A;  3ERB A;  4F4O C;  3OED C;  4MUC A;  3IU3 I;  3WSX A;  1E8B A;  4LOT A;  3F6K A;  2WII C;  2EC3 A;  1O9A A;  3TVJ A;  1E5G A; 
#chains in the Genus database with same CATH homology
 4MSL A;  2X2Z A;  4YIZ A;  3ZLE A;  2Y8S A;  4APL A;  2Y8T A;  4N7E A;  3FGR A;  3WSY A;  3FGT A;  3NJA A;  4BWC A;  4PO7 A;  2Y8R A;  3WSX A;  3F6K A;  3ZLD A;  2I2L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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