4AYDA

Structure of a complex between ccps 6 and 7 of human complement factor h and neisseria meningitidis fhbp variant 1 r106a mutant
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
123
structure length
123
Chain Sequence
TLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune system
source organism Homo sapiens
publication title Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules
pubmed doi rcsb
molecule keywords COMPLEMENT FACTOR H
total genus 22
structure length 123
sequence length 123
chains with identical sequence B, E
ec nomenclature
pdb deposition date 2012-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4aydA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4aydA01
1H04P 1OJYA 4DJZA 3ZD2A 1QO6A 1U5MA 4AYEA 2RKZA 4AYIA 1LY2A 2XQWC 3GXEA 1GHQB 3ZRZA 2JGXA 2IZ3A 4C16A 2O39C 4LOTA 1Z92B 1PPQA 3IX0A 1QGBA 1SRZA 5HYTB 4F4OC 1O9AA 1HCCA 3SW0X 1TPNA 4LOSA 1E88A 4YNXA 1G4FA 2JRAA 2KMSA 1E8BA 3R62A 4B2SA 5JPMG 2XRBA 2XWBF 4B2RA 2RLPA 2WIIC 1OK3A 3CALA 4IGDA 4KKDA 2JGWA 2YBYA 1SS2A 2XWJI 3MQLA 2UWNA 1HFIA 3OEDC 3KXVA 3L89M 2EC3A 2MCYA 2V8EA 3NFPI 1QUBA 1H2PP 2RKYA 1OK2A 4MUCA 3EJHA 3KZJA 3O8EB 1ZJKA 5HYUB 4ZH1D 1CKLA 3GOVA 4WJG2 2XRDA 1OK1A 3ERBA 1VVDA 1E5GA 1OK9A 1TPMA 4CSYA 4K12A 5FO8C 2CKUA 2G7IA 2W80A 1Q3XA 1MD7A 1HFHA 3ZD1A 1GKNA 5I0QB 2ERJA 4PZ5A 3TVJA 1UOTP 1ELVA 1VVCA 1GPZA 2RLQA 3T5OA 2YRAA 1H2QP 3INBC 3OP8A 2B5ID 2W81A 1H03P 3M7PA 2CG6A 1OJWA 3RJ3D 4J38B 4FXGG 5HYPA 1TPGA 2MCZA 1OJVA 1MD8A 4AYMA 2BZMA 2EHFA 1C1ZA 1GKGA 2A55A 4AYDA 4JHSA 3OXUD 2LOJA 2KRIA 2RL0A 3IU3I 4ONTD 1FBRA 1G4GA 5HZPB 4A5WB 2IZ4A 2CG7A 1NWVA 2QY0A
chains in the Genus database with same CATH superfamily
1H04P 1OJYA 4MSLA 4DJZA 4N7EA 3ZD2A 1QO6A 1U5MA 4AYEA 2RKZA 4AYIA 3FGTA 1LY2A 2XQWC 3GXEA 1GHQB 3ZRZA 2JGXA 2IZ3A 4C16A 2O39C 4LOTA 1Z92B 1PPQA 3IX0A 1QGBA 1SRZA 5HYTB 3F6KA 4F4OC 1O9AA 1HCCA 3SW0X 1TPNA 4LOSA 1E88A 4YNXA 4YIZA 1G4FA 2JRAA 2KMSA 1E8BA 3R62A 4B2SA 5JPMG 2XRBA 4PO7A 2XWBF 4B2RA 2RLPA 2WIIC 1OK3A 3CALA 4IGDA 4KKDA 2JGWA 2YBYA 1SS2A 2XWJI 3MQLA 2UWNA 1HFIA 3OEDC 3KXVA 3L89M 3ZLDA 2EC3A 2MCYA 2V8EA 2X2ZA 3NFPI 3WSYA 3CI0J 1QUBA 1H2PP 2RKYA 1OK2A 4MUCA 3EJHA 3KZJA 3VWOA 3O8EB 1ZJKA 3WSXA 5HYUB 4ZH1D 1CKLA 3GOVA 4WJG2 2XRDA 1OK1A 3ERBA 4APLA 5DN5A 1VVDA 1E5GA 1OK9A 1TPMA 2Y8SA 2Y8TA 4CSYA 4K12A 5FO8C 2CKUA 2ZYCA 2G7IA 2W80A 3K3TA 1Q3XA 1MD7A 1HFHA 3ZD1A 1GKNA 5I0QB 2ERJA 4PZ5A 3TVJA 1UOTP 3NJAA 1ELVA 1VVCA 1GPZA 2RLQA 3T5OA 2YRAA 1H2QP 3INBC 3OP8A 2B5ID 2W81A 1H03P 3M7PA 2I2LA 2CG6A 1OJWA 3RJ3D 4J38B 4FXGG 2Y8RA 5HYPA 1TPGA 2MCZA 1OJVA 1MD8A 4AYMA 2BZMA 2EHFA 1C1ZA 1GKGA 2A55A 5DN4A 4AYDA 4JHSA 3OXUD 2LOJA 2KRIA 2RL0A 3FGRA 3IU3I 1FBRA 4ONTD 3ZLEA 1G4GA 5HZPB 4A5WB 2IZ4A 2CG7A 1NWVA 4BWCA 2QY0A 1RLHA
chains in the Genus database with same CATH topology
1H04P 1OJYA 4DJZA 3ZD2A 1QO6A 1U5MA 4AYEA 2RKZA 4AYIA 1LY2A 2XQWC 3GXEA 1GHQB 3ZRZA 2JGXA 2IZ3A 4C16A 2O39C 4LOTA 1Z92B 1PPQA 3IX0A 1QGBA 1SRZA 5HYTB 4F4OC 1O9AA 1HCCA 3SW0X 1TPNA 4LOSA 1E88A 4YNXA 1G4FA 2JRAA 2KMSA 1E8BA 3R62A 4B2SA 5JPMG 2XRBA 2XWBF 4B2RA 2RLPA 2WIIC 1OK3A 3CALA 4IGDA 4KKDA 2JGWA 2YBYA 1SS2A 2XWJI 3MQLA 2UWNA 1HFIA 3OEDC 3KXVA 3L89M 2EC3A 2MCYA 2V8EA 3NFPI 1QUBA 1H2PP 2RKYA 1OK2A 4MUCA 3EJHA 3KZJA 3O8EB 1ZJKA 5HYUB 4ZH1D 1CKLA 3GOVA 4WJG2 2XRDA 1OK1A 3ERBA 1VVDA 1E5GA 1OK9A 1TPMA 4CSYA 4K12A 5FO8C 2CKUA 2G7IA 2W80A 1Q3XA 1MD7A 1HFHA 3ZD1A 1GKNA 5I0QB 2ERJA 4PZ5A 3TVJA 1UOTP 1ELVA 1VVCA 1GPZA 2RLQA 3T5OA 2YRAA 1H2QP 3INBC 3OP8A 2B5ID 2W81A 1H03P 3M7PA 2CG6A 1OJWA 3RJ3D 4J38B 4FXGG 5HYPA 1TPGA 2MCZA 1OJVA 1MD8A 4AYMA 2BZMA 2EHFA 1C1ZA 1GKGA 2A55A 4AYDA 4JHSA 3OXUD 2LOJA 2KRIA 2RL0A 3IU3I 4ONTD 1FBRA 1G4GA 5HZPB 4A5WB 2IZ4A 2CG7A 1NWVA 2QY0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H04 P;  1OJY A;  4DJZ A;  3ZD2 A;  1QO6 A;  1U5M A;  4AYE A;  2RKZ A;  4AYI A;  1LY2 A;  2XQW C;  3GXE A;  1GHQ B;  3ZRZ A;  2JGX A;  2IZ3 A;  4C16 A;  2O39 C;  4LOT A;  1Z92 B;  1PPQ A;  3IX0 A;  1QGB A;  1SRZ A;  5HYT B;  4F4O C;  1O9A A;  1HCC A;  3SW0 X;  1TPN A;  4LOS A;  1E88 A;  4YNX A;  1G4F A;  2JRA A;  2KMS A;  1E8B A;  3R62 A;  4B2S A;  5JPM G;  2XRB A;  2XWB F;  4B2R A;  2RLP A;  2WII C;  1OK3 A;  3CAL A;  4IGD A;  4KKD A;  2JGW A;  2YBY A;  1SS2 A;  2XWJ I;  3MQL A;  2UWN A;  1HFI A;  3OED C;  3KXV A;  3L89 M;  2EC3 A;  2MCY A;  2V8E A;  3NFP I;  1QUB A;  1H2P P;  2RKY A;  1OK2 A;  4MUC A;  3EJH A;  3KZJ A;  3O8E B;  1ZJK A;  5HYU B;  4ZH1 D;  1CKL A;  3GOV A;  4WJG 2;  2XRD A;  1OK1 A;  3ERB A;  1VVD A;  1E5G A;  1OK9 A;  1TPM A;  4CSY A;  4K12 A;  5FO8 C;  2CKU A;  2G7I A;  2W80 A;  1Q3X A;  1MD7 A;  1HFH A;  3ZD1 A;  1GKN A;  5I0Q B;  2ERJ A;  4PZ5 A;  3TVJ A;  1UOT P;  1ELV A;  1VVC A;  1GPZ A;  2RLQ A;  3T5O A;  2YRA A;  1H2Q P;  3INB C;  3OP8 A;  2B5I D;  2W81 A;  1H03 P;  3M7P A;  2CG6 A;  1OJW A;  3RJ3 D;  4J38 B;  4FXG G;  5HYP A;  1TPG A;  2MCZ A;  1OJV A;  1MD8 A;  4AYM A;  2BZM A;  2EHF A;  1C1Z A;  1GKG A;  2A55 A;  4AYD A;  4JHS A;  3OXU D;  2LOJ A;  2KRI A;  2RL0 A;  3IU3 I;  4ONT D;  1FBR A;  1G4G A;  5HZP B;  4A5W B;  2IZ4 A;  2CG7 A;  1NWV A;  2QY0 A; 
#chains in the Genus database with same CATH topology
 1H04 P;  1OJY A;  4MSL A;  4DJZ A;  4N7E A;  3ZD2 A;  1QO6 A;  1U5M A;  4AYE A;  2RKZ A;  4AYI A;  3FGT A;  1LY2 A;  2XQW C;  3GXE A;  1GHQ B;  3ZRZ A;  2JGX A;  2IZ3 A;  4C16 A;  2O39 C;  4LOT A;  1Z92 B;  1PPQ A;  3IX0 A;  1QGB A;  1SRZ A;  5HYT B;  3F6K A;  4F4O C;  1O9A A;  1HCC A;  3SW0 X;  1TPN A;  4LOS A;  1E88 A;  4YNX A;  4YIZ A;  1G4F A;  2JRA A;  2KMS A;  1E8B A;  3R62 A;  4B2S A;  5JPM G;  2XRB A;  4PO7 A;  2XWB F;  4B2R A;  2RLP A;  2WII C;  1OK3 A;  3CAL A;  4IGD A;  4KKD A;  2JGW A;  2YBY A;  1SS2 A;  2XWJ I;  3MQL A;  2UWN A;  1HFI A;  3OED C;  3KXV A;  3L89 M;  3ZLD A;  2EC3 A;  2MCY A;  2V8E A;  2X2Z A;  3NFP I;  3WSY A;  3CI0 J;  1QUB A;  1H2P P;  2RKY A;  1OK2 A;  4MUC A;  3EJH A;  3KZJ A;  3VWO A;  3O8E B;  1ZJK A;  3WSX A;  5HYU B;  4ZH1 D;  1CKL A;  3GOV A;  4WJG 2;  2XRD A;  1OK1 A;  3ERB A;  4APL A;  5DN5 A;  1VVD A;  1E5G A;  1OK9 A;  1TPM A;  2Y8S A;  2Y8T A;  4CSY A;  4K12 A;  5FO8 C;  2CKU A;  2ZYC A;  2G7I A;  2W80 A;  3K3T A;  1Q3X A;  1MD7 A;  1HFH A;  3ZD1 A;  1GKN A;  5I0Q B;  2ERJ A;  4PZ5 A;  3TVJ A;  1UOT P;  3NJA A;  1ELV A;  1VVC A;  1GPZ A;  2RLQ A;  3T5O A;  2YRA A;  1H2Q P;  3INB C;  3OP8 A;  2B5I D;  2W81 A;  1H03 P;  3M7P A;  2I2L A;  2CG6 A;  1OJW A;  3RJ3 D;  4J38 B;  4FXG G;  2Y8R A;  5HYP A;  1TPG A;  2MCZ A;  1OJV A;  1MD8 A;  4AYM A;  2BZM A;  2EHF A;  1C1Z A;  1GKG A;  2A55 A;  5DN4 A;  4AYD A;  4JHS A;  3OXU D;  2LOJ A;  2KRI A;  2RL0 A;  3FGR A;  3IU3 I;  1FBR A;  4ONT D;  3ZLE A;  1G4G A;  5HZP B;  4A5W B;  2IZ4 A;  2CG7 A;  1NWV A;  4BWC A;  2QY0 A;  1RLH A; 
#chains in the Genus database with same CATH homology
 1H04 P;  1OJY A;  4DJZ A;  3ZD2 A;  1QO6 A;  1U5M A;  4AYE A;  2RKZ A;  4AYI A;  1LY2 A;  2XQW C;  3GXE A;  1GHQ B;  3ZRZ A;  2JGX A;  2IZ3 A;  4C16 A;  2O39 C;  4LOT A;  1Z92 B;  1PPQ A;  3IX0 A;  1QGB A;  1SRZ A;  5HYT B;  4F4O C;  1O9A A;  1HCC A;  3SW0 X;  1TPN A;  4LOS A;  1E88 A;  4YNX A;  1G4F A;  2JRA A;  2KMS A;  1E8B A;  3R62 A;  4B2S A;  5JPM G;  2XRB A;  2XWB F;  4B2R A;  2RLP A;  2WII C;  1OK3 A;  3CAL A;  4IGD A;  4KKD A;  2JGW A;  2YBY A;  1SS2 A;  2XWJ I;  3MQL A;  2UWN A;  1HFI A;  3OED C;  3KXV A;  3L89 M;  2EC3 A;  2MCY A;  2V8E A;  3NFP I;  1QUB A;  1H2P P;  2RKY A;  1OK2 A;  4MUC A;  3EJH A;  3KZJ A;  3O8E B;  1ZJK A;  5HYU B;  4ZH1 D;  1CKL A;  3GOV A;  4WJG 2;  2XRD A;  1OK1 A;  3ERB A;  1VVD A;  1E5G A;  1OK9 A;  1TPM A;  4CSY A;  4K12 A;  5FO8 C;  2CKU A;  2G7I A;  2W80 A;  1Q3X A;  1MD7 A;  1HFH A;  3ZD1 A;  1GKN A;  5I0Q B;  2ERJ A;  4PZ5 A;  3TVJ A;  1UOT P;  1ELV A;  1VVC A;  1GPZ A;  2RLQ A;  3T5O A;  2YRA A;  1H2Q P;  3INB C;  3OP8 A;  2B5I D;  2W81 A;  1H03 P;  3M7P A;  2CG6 A;  1OJW A;  3RJ3 D;  4J38 B;  4FXG G;  5HYP A;  1TPG A;  2MCZ A;  1OJV A;  1MD8 A;  4AYM A;  2BZM A;  2EHF A;  1C1Z A;  1GKG A;  2A55 A;  4AYD A;  4JHS A;  3OXU D;  2LOJ A;  2KRI A;  2RL0 A;  3IU3 I;  4ONT D;  1FBR A;  1G4G A;  5HZP B;  4A5W B;  2IZ4 A;  2CG7 A;  1NWV A;  2QY0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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