4AYDA

Structure of a complex between ccps 6 and 7 of human complement factor h and neisseria meningitidis fhbp variant 1 r106a mutant
Total Genus 22
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
123
structure length
123
Chain Sequence
TLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords COMPLEMENT FACTOR H
total genus 22
structure length 123
sequence length 123
chains with identical sequence B, E
ec nomenclature
pdb deposition date 2012-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4aydA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4aydA01
5FO8C 4DJZA 2MCZA 5HZPB 2XRDA 2A55A 1G4FA 1OK9A 4C16A 1QO6A 2JGWA 2MCYA 2RLPA 1H2PP 2YBYA 3L89M 4AYMA 5HYUB 1TPNA 1GHQB 3O8EB 4IGDA 2RL0A 4J38B 4AYDA 1OK2A 1GPZA 2RLQA 1SRZA 1OJYA 2W81A 3OXUD 3TVJA 1H2QP 4K12A 2O39C 1OK1A 1HFHA 5JPMG 2XWJI 4YNXA 2QY0A 1Q3XA 3GOVA 2XQWC 3ZD1A 2YRAA 2CG6A 2LOJA 4LOSA 1GKGA 4JHSA 1U5MA 1HFIA 2RKYA 2V8EA 2IZ3A 2CKUA 2KRIA 3IX0A 1VVDA 3KZJA 3GXEA 3M7PA 1E5GA 1OK3A 1C1ZA 1FBRA 4B2RA 2JRAA 1TPGA 1E8BA 2EC3A 1TPMA 1QUBA 1O9AA 2WIIC 3NFPI 4F4OC 1ELVA 3SW0X 1UOTP 3R62A 2W80A 1GKNA 2XWBF 2RKZA 1CKLA 2B5ID 3EJHA 4B2SA 1H04P 2G7IA 2EHFA 1HCCA 3RJ3D 5HYTB 1E88A 4AYEA 2CG7A 4KKDA 3KXVA 1OJWA 3ERBA 4ONTD 2JGXA 3ZRZA 4AYIA 2KMSA 2XRBA 1SS2A 2IZ4A 3MQLA 4CSYA 1H03P 3T5OA 1G4GA 1MD8A 2UWNA 3OP8A 1MD7A 4MUCA 4PZ5A 4ZH1D 1ZJKA 4LOTA 1NWVA 1OJVA 1LY2A 3IU3I 5I0QB 3INBC 4FXGG 1VVCA 5HYPA 4A5WB 1PPQA 3ZD2A 1QGBA 1Z92B 2ERJA 3OEDC 4WJG2 3CALA 2BZMA
chains in the Genus database with same CATH superfamily
5FO8C 4DJZA 2MCZA 5HZPB 2XRDA 2A55A 1G4FA 1OK9A 4PO7A 4C16A 1QO6A 2JGWA 2MCYA 2RLPA 1H2PP 2YBYA 3L89M 4AYMA 5HYUB 4BWCA 1TPNA 1GHQB 3O8EB 4IGDA 2RL0A 4J38B 4AYDA 1OK2A 1GPZA 2RLQA 2I2LA 1SRZA 1OJYA 2W81A 2Y8SA 3OXUD 3TVJA 1H2QP 4K12A 2O39C 1OK1A 1HFHA 5JPMG 2XWJI 4YNXA 2QY0A 5DN4A 1Q3XA 2Y8TA 3GOVA 2XQWC 3ZD1A 2YRAA 2CG6A 3WSYA 2LOJA 4LOSA 1GKGA 4JHSA 1U5MA 1HFIA 2RKYA 2V8EA 3WSXA 4APLA 2IZ3A 2CKUA 2KRIA 3IX0A 1VVDA 3KZJA 4MSLA 3GXEA 3M7PA 1E5GA 1OK3A 1C1ZA 1FBRA 4B2RA 2JRAA 1TPGA 1E8BA 2EC3A 3CI0J 1TPMA 1QUBA 1O9AA 2WIIC 3NFPI 4N7EA 1ELVA 4F4OC 3SW0X 1UOTP 3R62A 2W80A 1GKNA 2XWBF 2RKZA 1CKLA 2B5ID 3EJHA 4B2SA 1H04P 2G7IA 2EHFA 1HCCA 3RJ3D 5HYTB 1E88A 4AYEA 2CG7A 4KKDA 3KXVA 1OJWA 3ERBA 4ONTD 2JGXA 3ZRZA 4AYIA 2KMSA 2XRBA 1SS2A 1RLHA 2IZ4A 3MQLA 3FGTA 4CSYA 1H03P 3T5OA 1G4GA 1MD8A 2UWNA 3FGRA 1MD7A 3OP8A 4MUCA 4PZ5A 4ZH1D 3K3TA 1ZJKA 4LOTA 1NWVA 2Y8RA 1OJVA 1LY2A 3IU3I 5I0QB 3INBC 3ZLEA 5DN5A 4FXGG 1VVCA 2X2ZA 4YIZA 3ZLDA 3VWOA 3F6KA 5HYPA 4A5WB 1PPQA 2ZYCA 3NJAA 1QGBA 3ZD2A 1Z92B 2ERJA 3OEDC 4WJG2 3CALA 2BZMA
chains in the Genus database with same CATH topology
5FO8C 4DJZA 2MCZA 5HZPB 2XRDA 2A55A 1G4FA 1OK9A 4C16A 1QO6A 2JGWA 2MCYA 2RLPA 1H2PP 2YBYA 3L89M 4AYMA 5HYUB 1TPNA 1GHQB 3O8EB 4IGDA 2RL0A 4J38B 4AYDA 1OK2A 1GPZA 2RLQA 1SRZA 1OJYA 2W81A 3OXUD 3TVJA 1H2QP 4K12A 2O39C 1OK1A 1HFHA 5JPMG 2XWJI 4YNXA 2QY0A 1Q3XA 3GOVA 2XQWC 3ZD1A 2YRAA 2CG6A 2LOJA 4LOSA 1GKGA 4JHSA 1U5MA 1HFIA 2RKYA 2V8EA 2IZ3A 2CKUA 2KRIA 3IX0A 1VVDA 3KZJA 3GXEA 3M7PA 1E5GA 1OK3A 1C1ZA 1FBRA 4B2RA 2JRAA 1TPGA 1E8BA 2EC3A 1TPMA 1QUBA 1O9AA 2WIIC 3NFPI 4F4OC 1ELVA 3SW0X 1UOTP 3R62A 2W80A 1GKNA 2XWBF 2RKZA 1CKLA 2B5ID 3EJHA 4B2SA 1H04P 2G7IA 2EHFA 1HCCA 3RJ3D 5HYTB 1E88A 4AYEA 2CG7A 4KKDA 3KXVA 1OJWA 3ERBA 4ONTD 2JGXA 3ZRZA 4AYIA 2KMSA 2XRBA 1SS2A 2IZ4A 3MQLA 4CSYA 1H03P 3T5OA 1G4GA 1MD8A 2UWNA 3OP8A 1MD7A 4MUCA 4PZ5A 4ZH1D 1ZJKA 4LOTA 1NWVA 1OJVA 1LY2A 3IU3I 5I0QB 3INBC 4FXGG 1VVCA 5HYPA 4A5WB 1PPQA 3ZD2A 1QGBA 1Z92B 2ERJA 3OEDC 4WJG2 3CALA 2BZMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FO8 C;  4DJZ A;  2MCZ A;  5HZP B;  2XRD A;  2A55 A;  1G4F A;  1OK9 A;  4C16 A;  1QO6 A;  2JGW A;  2MCY A;  2RLP A;  1H2P P;  2YBY A;  3L89 M;  4AYM A;  5HYU B;  1TPN A;  1GHQ B;  3O8E B;  4IGD A;  2RL0 A;  4J38 B;  4AYD A;  1OK2 A;  1GPZ A;  2RLQ A;  1SRZ A;  1OJY A;  2W81 A;  3OXU D;  3TVJ A;  1H2Q P;  4K12 A;  2O39 C;  1OK1 A;  1HFH A;  5JPM G;  2XWJ I;  4YNX A;  2QY0 A;  1Q3X A;  3GOV A;  2XQW C;  3ZD1 A;  2YRA A;  2CG6 A;  2LOJ A;  4LOS A;  1GKG A;  4JHS A;  1U5M A;  1HFI A;  2RKY A;  2V8E A;  2IZ3 A;  2CKU A;  2KRI A;  3IX0 A;  1VVD A;  3KZJ A;  3GXE A;  3M7P A;  1E5G A;  1OK3 A;  1C1Z A;  1FBR A;  4B2R A;  2JRA A;  1TPG A;  1E8B A;  2EC3 A;  1TPM A;  1QUB A;  1O9A A;  2WII C;  3NFP I;  4F4O C;  1ELV A;  3SW0 X;  1UOT P;  3R62 A;  2W80 A;  1GKN A;  2XWB F;  2RKZ A;  1CKL A;  2B5I D;  3EJH A;  4B2S A;  1H04 P;  2G7I A;  2EHF A;  1HCC A;  3RJ3 D;  5HYT B;  1E88 A;  4AYE A;  2CG7 A;  4KKD A;  3KXV A;  1OJW A;  3ERB A;  4ONT D;  2JGX A;  3ZRZ A;  4AYI A;  2KMS A;  2XRB A;  1SS2 A;  2IZ4 A;  3MQL A;  4CSY A;  1H03 P;  3T5O A;  1G4G A;  1MD8 A;  2UWN A;  3OP8 A;  1MD7 A;  4MUC A;  4PZ5 A;  4ZH1 D;  1ZJK A;  4LOT A;  1NWV A;  1OJV A;  1LY2 A;  3IU3 I;  5I0Q B;  3INB C;  4FXG G;  1VVC A;  5HYP A;  4A5W B;  1PPQ A;  3ZD2 A;  1QGB A;  1Z92 B;  2ERJ A;  3OED C;  4WJG 2;  3CAL A;  2BZM A; 
#chains in the Genus database with same CATH topology
 5FO8 C;  4DJZ A;  2MCZ A;  5HZP B;  2XRD A;  2A55 A;  1G4F A;  1OK9 A;  4PO7 A;  4C16 A;  1QO6 A;  2JGW A;  2MCY A;  2RLP A;  1H2P P;  2YBY A;  3L89 M;  4AYM A;  5HYU B;  4BWC A;  1TPN A;  1GHQ B;  3O8E B;  4IGD A;  2RL0 A;  4J38 B;  4AYD A;  1OK2 A;  1GPZ A;  2RLQ A;  2I2L A;  1SRZ A;  1OJY A;  2W81 A;  2Y8S A;  3OXU D;  3TVJ A;  1H2Q P;  4K12 A;  2O39 C;  1OK1 A;  1HFH A;  5JPM G;  2XWJ I;  4YNX A;  2QY0 A;  5DN4 A;  1Q3X A;  2Y8T A;  3GOV A;  2XQW C;  3ZD1 A;  2YRA A;  2CG6 A;  3WSY A;  2LOJ A;  4LOS A;  1GKG A;  4JHS A;  1U5M A;  1HFI A;  2RKY A;  2V8E A;  3WSX A;  4APL A;  2IZ3 A;  2CKU A;  2KRI A;  3IX0 A;  1VVD A;  3KZJ A;  4MSL A;  3GXE A;  3M7P A;  1E5G A;  1OK3 A;  1C1Z A;  1FBR A;  4B2R A;  2JRA A;  1TPG A;  1E8B A;  2EC3 A;  3CI0 J;  1TPM A;  1QUB A;  1O9A A;  2WII C;  3NFP I;  4N7E A;  1ELV A;  4F4O C;  3SW0 X;  1UOT P;  3R62 A;  2W80 A;  1GKN A;  2XWB F;  2RKZ A;  1CKL A;  2B5I D;  3EJH A;  4B2S A;  1H04 P;  2G7I A;  2EHF A;  1HCC A;  3RJ3 D;  5HYT B;  1E88 A;  4AYE A;  2CG7 A;  4KKD A;  3KXV A;  1OJW A;  3ERB A;  4ONT D;  2JGX A;  3ZRZ A;  4AYI A;  2KMS A;  2XRB A;  1SS2 A;  1RLH A;  2IZ4 A;  3MQL A;  3FGT A;  4CSY A;  1H03 P;  3T5O A;  1G4G A;  1MD8 A;  2UWN A;  3FGR A;  1MD7 A;  3OP8 A;  4MUC A;  4PZ5 A;  4ZH1 D;  3K3T A;  1ZJK A;  4LOT A;  1NWV A;  2Y8R A;  1OJV A;  1LY2 A;  3IU3 I;  5I0Q B;  3INB C;  3ZLE A;  5DN5 A;  4FXG G;  1VVC A;  2X2Z A;  4YIZ A;  3ZLD A;  3VWO A;  3F6K A;  5HYP A;  4A5W B;  1PPQ A;  2ZYC A;  3NJA A;  1QGB A;  3ZD2 A;  1Z92 B;  2ERJ A;  3OED C;  4WJG 2;  3CAL A;  2BZM A; 
#chains in the Genus database with same CATH homology
 5FO8 C;  4DJZ A;  2MCZ A;  5HZP B;  2XRD A;  2A55 A;  1G4F A;  1OK9 A;  4C16 A;  1QO6 A;  2JGW A;  2MCY A;  2RLP A;  1H2P P;  2YBY A;  3L89 M;  4AYM A;  5HYU B;  1TPN A;  1GHQ B;  3O8E B;  4IGD A;  2RL0 A;  4J38 B;  4AYD A;  1OK2 A;  1GPZ A;  2RLQ A;  1SRZ A;  1OJY A;  2W81 A;  3OXU D;  3TVJ A;  1H2Q P;  4K12 A;  2O39 C;  1OK1 A;  1HFH A;  5JPM G;  2XWJ I;  4YNX A;  2QY0 A;  1Q3X A;  3GOV A;  2XQW C;  3ZD1 A;  2YRA A;  2CG6 A;  2LOJ A;  4LOS A;  1GKG A;  4JHS A;  1U5M A;  1HFI A;  2RKY A;  2V8E A;  2IZ3 A;  2CKU A;  2KRI A;  3IX0 A;  1VVD A;  3KZJ A;  3GXE A;  3M7P A;  1E5G A;  1OK3 A;  1C1Z A;  1FBR A;  4B2R A;  2JRA A;  1TPG A;  1E8B A;  2EC3 A;  1TPM A;  1QUB A;  1O9A A;  2WII C;  3NFP I;  4F4O C;  1ELV A;  3SW0 X;  1UOT P;  3R62 A;  2W80 A;  1GKN A;  2XWB F;  2RKZ A;  1CKL A;  2B5I D;  3EJH A;  4B2S A;  1H04 P;  2G7I A;  2EHF A;  1HCC A;  3RJ3 D;  5HYT B;  1E88 A;  4AYE A;  2CG7 A;  4KKD A;  3KXV A;  1OJW A;  3ERB A;  4ONT D;  2JGX A;  3ZRZ A;  4AYI A;  2KMS A;  2XRB A;  1SS2 A;  2IZ4 A;  3MQL A;  4CSY A;  1H03 P;  3T5O A;  1G4G A;  1MD8 A;  2UWN A;  3OP8 A;  1MD7 A;  4MUC A;  4PZ5 A;  4ZH1 D;  1ZJK A;  4LOT A;  1NWV A;  1OJV A;  1LY2 A;  3IU3 I;  5I0Q B;  3INB C;  4FXG G;  1VVC A;  5HYP A;  4A5W B;  1PPQ A;  3ZD2 A;  1QGB A;  1Z92 B;  2ERJ A;  3OED C;  4WJG 2;  3CAL A;  2BZM A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...