4AYMA

Structure of a complex between ccps 6 and 7 of human complement factor h and neisseria meningitidis fhbp variant 3 p106a mutant
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
119
structure length
119
Chain Sequence
CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords COMPLEMENT FACTOR H
total genus 21
structure length 119
sequence length 119
chains with identical sequence B, E, F
ec nomenclature
pdb deposition date 2012-06-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4aymA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4aymA01
1OK1A 1PPQA 1HFHA 3ERBA 3TVJA 3OEDC 1ELVA 2YRAA 4ZH1D 2QY0A 1SS2A 2KMSA 1OK9A 1QGBA 2IZ4A 4DJZA 2RKZA 4KKDA 1OK3A 4K12A 1CKLA 2JGXA 5JPMG 2ERJA 1MD7A 2EC3A 2MCYA 2V8EA 2CG7A 4C16A 2W81A 1TPNA 1H04P 3M7PA 5HYTB 2RKYA 3IU3I 3ZRZA 2G7IA 3NFPI 4MUCA 1FBRA 1ZJKA 1OK2A 3GXEA 3INBC 1TPGA 3EJHA 3T5OA 1U5MA 1LY2A 1MD8A 1SRZA 4LOSA 2KRIA 3SW0X 1VVDA 4ONTD 3CALA 1E88A 2JGWA 4A5WB 1NWVA 2IZ3A 2LOJA 4AYDA 4WJG2 1UOTP 1GHQB 2O39C 2W80A 2XWBF 1QUBA 2RLQA 1HCCA 2YBYA 3ZD1A 1QO6A 1E8BA 3L89M 3ZD2A 5HZPB 1TPMA 2XRDA 2EHFA 1O9AA 2B5ID 2RL0A 2CKUA 1HFIA 3R62A 3RJ3D 2BZMA 1H03P 2CG6A 4LOTA 5I0QB 2JRAA 2MCZA 4IGDA 5HYUB 4FXGG 4AYEA 3KXVA 1GKNA 3GOVA 4F4OC 1OJYA 2A55A 4YNXA 1C1ZA 4AYMA 4B2RA 3OP8A 1E5GA 2UWNA 3IX0A 4PZ5A 2WIIC 1OJVA 2RLPA 1Z92B 1G4FA 4CSYA 2XQWC 2XRBA 1H2PP 1OJWA 4J38B 1Q3XA 5FO8C 4B2SA 3MQLA 1GPZA 3O8EB 1GKGA 2XWJI 1VVCA 5HYPA 3OXUD 4AYIA 4JHSA 3KZJA 1G4GA 1H2QP
chains in the Genus database with same CATH superfamily
1OK1A 4MSLA 1PPQA 1HFHA 3ERBA 3TVJA 3OEDC 1ELVA 2YRAA 4ZH1D 5DN5A 2QY0A 1SS2A 2KMSA 1OK9A 1QGBA 2IZ4A 4DJZA 2ZYCA 2RKZA 4KKDA 1OK3A 4K12A 1CKLA 2JGXA 4YIZA 3FGTA 5JPMG 2ERJA 1MD7A 2EC3A 3FGRA 2MCYA 2V8EA 2CG7A 4C16A 2W81A 1TPNA 1H04P 3M7PA 5HYTB 2RKYA 3IU3I 3ZRZA 2G7IA 3NFPI 4MUCA 1FBRA 1RLHA 1ZJKA 1OK2A 2Y8SA 3GXEA 3INBC 1TPGA 3EJHA 3F6KA 3T5OA 1U5MA 3WSYA 1LY2A 1MD8A 1SRZA 4LOSA 2KRIA 3SW0X 4N7EA 1VVDA 4ONTD 4BWCA 3CALA 5DN4A 1E88A 2JGWA 4A5WB 1NWVA 2IZ3A 2LOJA 4AYDA 4WJG2 1UOTP 1GHQB 2O39C 2W80A 2XWBF 1QUBA 2RLQA 1HCCA 2YBYA 3ZD1A 1QO6A 1E8BA 3L89M 3ZD2A 5HZPB 1TPMA 3K3TA 2XRDA 2EHFA 1O9AA 2B5ID 2Y8TA 2RL0A 2CKUA 1HFIA 3R62A 3RJ3D 2BZMA 1H03P 2CG6A 4LOTA 5I0QB 2JRAA 2MCZA 4IGDA 4APLA 5HYUB 4FXGG 4AYEA 3KXVA 1GKNA 3GOVA 4F4OC 1OJYA 2A55A 4YNXA 1C1ZA 4PO7A 4AYMA 4B2RA 3OP8A 1E5GA 2UWNA 3IX0A 3NJAA 4PZ5A 2I2LA 2WIIC 1OJVA 2RLPA 1Z92B 1G4FA 4CSYA 2XQWC 2Y8RA 3CI0J 2XRBA 1H2PP 1OJWA 2X2ZA 4J38B 1Q3XA 5FO8C 4B2SA 3WSXA 3MQLA 1GPZA 3O8EB 3VWOA 1GKGA 2XWJI 1VVCA 5HYPA 3OXUD 4AYIA 4JHSA 3KZJA 3ZLDA 1G4GA 3ZLEA 1H2QP
chains in the Genus database with same CATH topology
1OK1A 1PPQA 1HFHA 3ERBA 3TVJA 3OEDC 1ELVA 2YRAA 4ZH1D 2QY0A 1SS2A 2KMSA 1OK9A 1QGBA 2IZ4A 4DJZA 2RKZA 4KKDA 1OK3A 4K12A 1CKLA 2JGXA 5JPMG 2ERJA 1MD7A 2EC3A 2MCYA 2V8EA 2CG7A 4C16A 2W81A 1TPNA 1H04P 3M7PA 5HYTB 2RKYA 3IU3I 3ZRZA 2G7IA 3NFPI 4MUCA 1FBRA 1ZJKA 1OK2A 3GXEA 3INBC 1TPGA 3EJHA 3T5OA 1U5MA 1LY2A 1MD8A 1SRZA 4LOSA 2KRIA 3SW0X 1VVDA 4ONTD 3CALA 1E88A 2JGWA 4A5WB 1NWVA 2IZ3A 2LOJA 4AYDA 4WJG2 1UOTP 1GHQB 2O39C 2W80A 2XWBF 1QUBA 2RLQA 1HCCA 2YBYA 3ZD1A 1QO6A 1E8BA 3L89M 3ZD2A 5HZPB 1TPMA 2XRDA 2EHFA 1O9AA 2B5ID 2RL0A 2CKUA 1HFIA 3R62A 3RJ3D 2BZMA 1H03P 2CG6A 4LOTA 5I0QB 2JRAA 2MCZA 4IGDA 5HYUB 4FXGG 4AYEA 3KXVA 1GKNA 3GOVA 4F4OC 1OJYA 2A55A 4YNXA 1C1ZA 4AYMA 4B2RA 3OP8A 1E5GA 2UWNA 3IX0A 4PZ5A 2WIIC 1OJVA 2RLPA 1Z92B 1G4FA 4CSYA 2XQWC 2XRBA 1H2PP 1OJWA 4J38B 1Q3XA 5FO8C 4B2SA 3MQLA 1GPZA 3O8EB 1GKGA 2XWJI 1VVCA 5HYPA 3OXUD 4AYIA 4JHSA 3KZJA 1G4GA 1H2QP
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OK1 A;  1PPQ A;  1HFH A;  3ERB A;  3TVJ A;  3OED C;  1ELV A;  2YRA A;  4ZH1 D;  2QY0 A;  1SS2 A;  2KMS A;  1OK9 A;  1QGB A;  2IZ4 A;  4DJZ A;  2RKZ A;  4KKD A;  1OK3 A;  4K12 A;  1CKL A;  2JGX A;  5JPM G;  2ERJ A;  1MD7 A;  2EC3 A;  2MCY A;  2V8E A;  2CG7 A;  4C16 A;  2W81 A;  1TPN A;  1H04 P;  3M7P A;  5HYT B;  2RKY A;  3IU3 I;  3ZRZ A;  2G7I A;  3NFP I;  4MUC A;  1FBR A;  1ZJK A;  1OK2 A;  3GXE A;  3INB C;  1TPG A;  3EJH A;  3T5O A;  1U5M A;  1LY2 A;  1MD8 A;  1SRZ A;  4LOS A;  2KRI A;  3SW0 X;  1VVD A;  4ONT D;  3CAL A;  1E88 A;  2JGW A;  4A5W B;  1NWV A;  2IZ3 A;  2LOJ A;  4AYD A;  4WJG 2;  1UOT P;  1GHQ B;  2O39 C;  2W80 A;  2XWB F;  1QUB A;  2RLQ A;  1HCC A;  2YBY A;  3ZD1 A;  1QO6 A;  1E8B A;  3L89 M;  3ZD2 A;  5HZP B;  1TPM A;  2XRD A;  2EHF A;  1O9A A;  2B5I D;  2RL0 A;  2CKU A;  1HFI A;  3R62 A;  3RJ3 D;  2BZM A;  1H03 P;  2CG6 A;  4LOT A;  5I0Q B;  2JRA A;  2MCZ A;  4IGD A;  5HYU B;  4FXG G;  4AYE A;  3KXV A;  1GKN A;  3GOV A;  4F4O C;  1OJY A;  2A55 A;  4YNX A;  1C1Z A;  4AYM A;  4B2R A;  3OP8 A;  1E5G A;  2UWN A;  3IX0 A;  4PZ5 A;  2WII C;  1OJV A;  2RLP A;  1Z92 B;  1G4F A;  4CSY A;  2XQW C;  2XRB A;  1H2P P;  1OJW A;  4J38 B;  1Q3X A;  5FO8 C;  4B2S A;  3MQL A;  1GPZ A;  3O8E B;  1GKG A;  2XWJ I;  1VVC A;  5HYP A;  3OXU D;  4AYI A;  4JHS A;  3KZJ A;  1G4G A;  1H2Q P; 
#chains in the Genus database with same CATH topology
 1OK1 A;  4MSL A;  1PPQ A;  1HFH A;  3ERB A;  3TVJ A;  3OED C;  1ELV A;  2YRA A;  4ZH1 D;  5DN5 A;  2QY0 A;  1SS2 A;  2KMS A;  1OK9 A;  1QGB A;  2IZ4 A;  4DJZ A;  2ZYC A;  2RKZ A;  4KKD A;  1OK3 A;  4K12 A;  1CKL A;  2JGX A;  4YIZ A;  3FGT A;  5JPM G;  2ERJ A;  1MD7 A;  2EC3 A;  3FGR A;  2MCY A;  2V8E A;  2CG7 A;  4C16 A;  2W81 A;  1TPN A;  1H04 P;  3M7P A;  5HYT B;  2RKY A;  3IU3 I;  3ZRZ A;  2G7I A;  3NFP I;  4MUC A;  1FBR A;  1RLH A;  1ZJK A;  1OK2 A;  2Y8S A;  3GXE A;  3INB C;  1TPG A;  3EJH A;  3F6K A;  3T5O A;  1U5M A;  3WSY A;  1LY2 A;  1MD8 A;  1SRZ A;  4LOS A;  2KRI A;  3SW0 X;  4N7E A;  1VVD A;  4ONT D;  4BWC A;  3CAL A;  5DN4 A;  1E88 A;  2JGW A;  4A5W B;  1NWV A;  2IZ3 A;  2LOJ A;  4AYD A;  4WJG 2;  1UOT P;  1GHQ B;  2O39 C;  2W80 A;  2XWB F;  1QUB A;  2RLQ A;  1HCC A;  2YBY A;  3ZD1 A;  1QO6 A;  1E8B A;  3L89 M;  3ZD2 A;  5HZP B;  1TPM A;  3K3T A;  2XRD A;  2EHF A;  1O9A A;  2B5I D;  2Y8T A;  2RL0 A;  2CKU A;  1HFI A;  3R62 A;  3RJ3 D;  2BZM A;  1H03 P;  2CG6 A;  4LOT A;  5I0Q B;  2JRA A;  2MCZ A;  4IGD A;  4APL A;  5HYU B;  4FXG G;  4AYE A;  3KXV A;  1GKN A;  3GOV A;  4F4O C;  1OJY A;  2A55 A;  4YNX A;  1C1Z A;  4PO7 A;  4AYM A;  4B2R A;  3OP8 A;  1E5G A;  2UWN A;  3IX0 A;  3NJA A;  4PZ5 A;  2I2L A;  2WII C;  1OJV A;  2RLP A;  1Z92 B;  1G4F A;  4CSY A;  2XQW C;  2Y8R A;  3CI0 J;  2XRB A;  1H2P P;  1OJW A;  2X2Z A;  4J38 B;  1Q3X A;  5FO8 C;  4B2S A;  3WSX A;  3MQL A;  1GPZ A;  3O8E B;  3VWO A;  1GKG A;  2XWJ I;  1VVC A;  5HYP A;  3OXU D;  4AYI A;  4JHS A;  3KZJ A;  3ZLD A;  1G4G A;  3ZLE A;  1H2Q P; 
#chains in the Genus database with same CATH homology
 1OK1 A;  1PPQ A;  1HFH A;  3ERB A;  3TVJ A;  3OED C;  1ELV A;  2YRA A;  4ZH1 D;  2QY0 A;  1SS2 A;  2KMS A;  1OK9 A;  1QGB A;  2IZ4 A;  4DJZ A;  2RKZ A;  4KKD A;  1OK3 A;  4K12 A;  1CKL A;  2JGX A;  5JPM G;  2ERJ A;  1MD7 A;  2EC3 A;  2MCY A;  2V8E A;  2CG7 A;  4C16 A;  2W81 A;  1TPN A;  1H04 P;  3M7P A;  5HYT B;  2RKY A;  3IU3 I;  3ZRZ A;  2G7I A;  3NFP I;  4MUC A;  1FBR A;  1ZJK A;  1OK2 A;  3GXE A;  3INB C;  1TPG A;  3EJH A;  3T5O A;  1U5M A;  1LY2 A;  1MD8 A;  1SRZ A;  4LOS A;  2KRI A;  3SW0 X;  1VVD A;  4ONT D;  3CAL A;  1E88 A;  2JGW A;  4A5W B;  1NWV A;  2IZ3 A;  2LOJ A;  4AYD A;  4WJG 2;  1UOT P;  1GHQ B;  2O39 C;  2W80 A;  2XWB F;  1QUB A;  2RLQ A;  1HCC A;  2YBY A;  3ZD1 A;  1QO6 A;  1E8B A;  3L89 M;  3ZD2 A;  5HZP B;  1TPM A;  2XRD A;  2EHF A;  1O9A A;  2B5I D;  2RL0 A;  2CKU A;  1HFI A;  3R62 A;  3RJ3 D;  2BZM A;  1H03 P;  2CG6 A;  4LOT A;  5I0Q B;  2JRA A;  2MCZ A;  4IGD A;  5HYU B;  4FXG G;  4AYE A;  3KXV A;  1GKN A;  3GOV A;  4F4O C;  1OJY A;  2A55 A;  4YNX A;  1C1Z A;  4AYM A;  4B2R A;  3OP8 A;  1E5G A;  2UWN A;  3IX0 A;  4PZ5 A;  2WII C;  1OJV A;  2RLP A;  1Z92 B;  1G4F A;  4CSY A;  2XQW C;  2XRB A;  1H2P P;  1OJW A;  4J38 B;  1Q3X A;  5FO8 C;  4B2S A;  3MQL A;  1GPZ A;  3O8E B;  1GKG A;  2XWJ I;  1VVC A;  5HYP A;  3OXU D;  4AYI A;  4JHS A;  3KZJ A;  1G4G A;  1H2Q P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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