4AYMA

Structure of a complex between ccps 6 and 7 of human complement factor h and neisseria meningitidis fhbp variant 3 p106a mutant
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
119
structure length
119
Chain Sequence
CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune system
source organism Homo sapiens
publication title Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
pubmed doi rcsb
molecule keywords COMPLEMENT FACTOR H
total genus 21
structure length 119
sequence length 119
chains with identical sequence B, E, F
ec nomenclature
pdb deposition date 2012-06-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4aymA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4aymA01
4K12A 4KKDA 1G4FA 2XWBF 2MCYA 3OXUD 2CG6A 4LOSA 1E5GA 3R62A 5HZPB 2XRBA 2JRAA 3T5OA 2EHFA 3OEDC 2IZ3A 2XRDA 1G4GA 2RLPA 1Q3XA 2MCZA 4MUCA 1NWVA 2V8EA 2ERJA 4B2RA 1QGBA 1VVCA 5HYUB 1HFIA 1OK2A 2W81A 2CG7A 1OJVA 1CKLA 3RJ3D 1MD8A 1H03P 1TPGA 2UWNA 1QO6A 3KZJA 4CSYA 1E8BA 5JPMG 2B5ID 1HFHA 1LY2A 3ZRZA 1GPZA 1GHQB 1SRZA 3O8EB 1OK1A 1SS2A 2KRIA 2IZ4A 1ZJKA 1OK3A 3MQLA 3ZD1A 1C1ZA 1U5MA 3M7PA 3KXVA 2BZMA 1E88A 2RL0A 1FBRA 2G7IA 1QUBA 3TVJA 3L89M 2A55A 4ONTD 4AYDA 2XQWC 5FO8C 2WIIC 4AYIA 3OP8A 2LOJA 2JGXA 1OK9A 1OJWA 4FXGG 3GXEA 4C16A 3GOVA 1H04P 1MD7A 3NFPI 2W80A 2RKZA 2YRAA 2EC3A 2O39C 4IGDA 4PZ5A 1VVDA 1GKNA 2KMSA 1UOTP 3INBC 1TPMA 2JGWA 4ZH1D 5HYPA 1Z92B 5I0QB 1TPNA 3CALA 3SW0X 4LOTA 3EJHA 1HCCA 4A5WB 4JHSA 4AYMA 3IU3I 3ZD2A 1OJYA 4AYEA 4YNXA 2YBYA 3IX0A 1PPQA 4J38B 2RKYA 5HYTB 1ELVA 1O9AA 3ERBA 1H2PP 2RLQA 4B2SA 2QY0A 4WJG2 2CKUA 2XWJI 4F4OC 1H2QP 4DJZA 1GKGA
chains in the Genus database with same CATH superfamily
4K12A 4KKDA 1G4FA 2XWBF 2MCYA 3WSYA 3OXUD 2Y8RA 2CG6A 4LOSA 1E5GA 3R62A 4PO7A 2XRBA 2JRAA 5HZPB 4YIZA 3T5OA 2EHFA 3OEDC 2IZ3A 1G4GA 2XRDA 2RLPA 1Q3XA 2MCZA 4MUCA 1NWVA 2V8EA 2ERJA 4B2RA 1QGBA 1VVCA 5HYUB 2I2LA 1HFIA 1OK2A 2W81A 2CG7A 1OJVA 1CKLA 3RJ3D 1MD8A 1H03P 1TPGA 2UWNA 1QO6A 3KZJA 4CSYA 1E8BA 5JPMG 2B5ID 1HFHA 5DN4A 1LY2A 3ZLDA 1GPZA 1GHQB 1SRZA 3O8EB 3ZRZA 4BWCA 1OK1A 1SS2A 2KRIA 2IZ4A 1ZJKA 1OK3A 3MQLA 3ZD1A 1C1ZA 1U5MA 3M7PA 3KXVA 2BZMA 1E88A 2RL0A 1FBRA 2G7IA 1QUBA 4N7EA 3TVJA 3L89M 3VWOA 2A55A 4ONTD 4AYDA 2XQWC 5FO8C 2WIIC 4AYIA 3OP8A 2LOJA 2JGXA 1OK9A 4MSLA 1OJWA 4FXGG 2Y8TA 3GXEA 3ZLEA 4C16A 3CI0J 3GOVA 1H04P 3NJAA 1MD7A 3NFPI 2W80A 2RKZA 2YRAA 3K3TA 2EC3A 2O39C 4IGDA 4PZ5A 1VVDA 2X2ZA 1GKNA 2KMSA 3F6KA 1UOTP 3INBC 1TPMA 3FGRA 2JGWA 4ZH1D 3FGTA 5HYPA 1Z92B 5I0QB 2Y8SA 1TPNA 3CALA 3SW0X 5DN5A 4LOTA 3EJHA 1HCCA 4A5WB 4JHSA 4AYMA 3IU3I 3ZD2A 1OJYA 2ZYCA 4AYEA 4YNXA 2YBYA 3IX0A 1PPQA 4J38B 2RKYA 5HYTB 3WSXA 1ELVA 1RLHA 1O9AA 3ERBA 1H2PP 2RLQA 4B2SA 4APLA 2QY0A 4WJG2 2CKUA 2XWJI 4F4OC 1H2QP 4DJZA 1GKGA
chains in the Genus database with same CATH topology
4K12A 4KKDA 1G4FA 2XWBF 2MCYA 3OXUD 2CG6A 4LOSA 1E5GA 3R62A 5HZPB 2XRBA 2JRAA 3T5OA 2EHFA 3OEDC 2IZ3A 2XRDA 1G4GA 2RLPA 1Q3XA 2MCZA 4MUCA 1NWVA 2V8EA 2ERJA 4B2RA 1QGBA 1VVCA 5HYUB 1HFIA 1OK2A 2W81A 2CG7A 1OJVA 1CKLA 3RJ3D 1MD8A 1H03P 1TPGA 2UWNA 1QO6A 3KZJA 4CSYA 1E8BA 5JPMG 2B5ID 1HFHA 1LY2A 3ZRZA 1GPZA 1GHQB 1SRZA 3O8EB 1OK1A 1SS2A 2KRIA 2IZ4A 1ZJKA 1OK3A 3MQLA 3ZD1A 1C1ZA 1U5MA 3M7PA 3KXVA 2BZMA 1E88A 2RL0A 1FBRA 2G7IA 1QUBA 3TVJA 3L89M 2A55A 4ONTD 4AYDA 2XQWC 5FO8C 2WIIC 4AYIA 3OP8A 2LOJA 2JGXA 1OK9A 1OJWA 4FXGG 3GXEA 4C16A 3GOVA 1H04P 1MD7A 3NFPI 2W80A 2RKZA 2YRAA 2EC3A 2O39C 4IGDA 4PZ5A 1VVDA 1GKNA 2KMSA 1UOTP 3INBC 1TPMA 2JGWA 4ZH1D 5HYPA 1Z92B 5I0QB 1TPNA 3CALA 3SW0X 4LOTA 3EJHA 1HCCA 4A5WB 4JHSA 4AYMA 3IU3I 3ZD2A 1OJYA 4AYEA 4YNXA 2YBYA 3IX0A 1PPQA 4J38B 2RKYA 5HYTB 1ELVA 1O9AA 3ERBA 1H2PP 2RLQA 4B2SA 2QY0A 4WJG2 2CKUA 2XWJI 4F4OC 1H2QP 4DJZA 1GKGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4K12 A;  4KKD A;  1G4F A;  2XWB F;  2MCY A;  3OXU D;  2CG6 A;  4LOS A;  1E5G A;  3R62 A;  5HZP B;  2XRB A;  2JRA A;  3T5O A;  2EHF A;  3OED C;  2IZ3 A;  2XRD A;  1G4G A;  2RLP A;  1Q3X A;  2MCZ A;  4MUC A;  1NWV A;  2V8E A;  2ERJ A;  4B2R A;  1QGB A;  1VVC A;  5HYU B;  1HFI A;  1OK2 A;  2W81 A;  2CG7 A;  1OJV A;  1CKL A;  3RJ3 D;  1MD8 A;  1H03 P;  1TPG A;  2UWN A;  1QO6 A;  3KZJ A;  4CSY A;  1E8B A;  5JPM G;  2B5I D;  1HFH A;  1LY2 A;  3ZRZ A;  1GPZ A;  1GHQ B;  1SRZ A;  3O8E B;  1OK1 A;  1SS2 A;  2KRI A;  2IZ4 A;  1ZJK A;  1OK3 A;  3MQL A;  3ZD1 A;  1C1Z A;  1U5M A;  3M7P A;  3KXV A;  2BZM A;  1E88 A;  2RL0 A;  1FBR A;  2G7I A;  1QUB A;  3TVJ A;  3L89 M;  2A55 A;  4ONT D;  4AYD A;  2XQW C;  5FO8 C;  2WII C;  4AYI A;  3OP8 A;  2LOJ A;  2JGX A;  1OK9 A;  1OJW A;  4FXG G;  3GXE A;  4C16 A;  3GOV A;  1H04 P;  1MD7 A;  3NFP I;  2W80 A;  2RKZ A;  2YRA A;  2EC3 A;  2O39 C;  4IGD A;  4PZ5 A;  1VVD A;  1GKN A;  2KMS A;  1UOT P;  3INB C;  1TPM A;  2JGW A;  4ZH1 D;  5HYP A;  1Z92 B;  5I0Q B;  1TPN A;  3CAL A;  3SW0 X;  4LOT A;  3EJH A;  1HCC A;  4A5W B;  4JHS A;  4AYM A;  3IU3 I;  3ZD2 A;  1OJY A;  4AYE A;  4YNX A;  2YBY A;  3IX0 A;  1PPQ A;  4J38 B;  2RKY A;  5HYT B;  1ELV A;  1O9A A;  3ERB A;  1H2P P;  2RLQ A;  4B2S A;  2QY0 A;  4WJG 2;  2CKU A;  2XWJ I;  4F4O C;  1H2Q P;  4DJZ A;  1GKG A; 
#chains in the Genus database with same CATH topology
 4K12 A;  4KKD A;  1G4F A;  2XWB F;  2MCY A;  3WSY A;  3OXU D;  2Y8R A;  2CG6 A;  4LOS A;  1E5G A;  3R62 A;  4PO7 A;  2XRB A;  2JRA A;  5HZP B;  4YIZ A;  3T5O A;  2EHF A;  3OED C;  2IZ3 A;  1G4G A;  2XRD A;  2RLP A;  1Q3X A;  2MCZ A;  4MUC A;  1NWV A;  2V8E A;  2ERJ A;  4B2R A;  1QGB A;  1VVC A;  5HYU B;  2I2L A;  1HFI A;  1OK2 A;  2W81 A;  2CG7 A;  1OJV A;  1CKL A;  3RJ3 D;  1MD8 A;  1H03 P;  1TPG A;  2UWN A;  1QO6 A;  3KZJ A;  4CSY A;  1E8B A;  5JPM G;  2B5I D;  1HFH A;  5DN4 A;  1LY2 A;  3ZLD A;  1GPZ A;  1GHQ B;  1SRZ A;  3O8E B;  3ZRZ A;  4BWC A;  1OK1 A;  1SS2 A;  2KRI A;  2IZ4 A;  1ZJK A;  1OK3 A;  3MQL A;  3ZD1 A;  1C1Z A;  1U5M A;  3M7P A;  3KXV A;  2BZM A;  1E88 A;  2RL0 A;  1FBR A;  2G7I A;  1QUB A;  4N7E A;  3TVJ A;  3L89 M;  3VWO A;  2A55 A;  4ONT D;  4AYD A;  2XQW C;  5FO8 C;  2WII C;  4AYI A;  3OP8 A;  2LOJ A;  2JGX A;  1OK9 A;  4MSL A;  1OJW A;  4FXG G;  2Y8T A;  3GXE A;  3ZLE A;  4C16 A;  3CI0 J;  3GOV A;  1H04 P;  3NJA A;  1MD7 A;  3NFP I;  2W80 A;  2RKZ A;  2YRA A;  3K3T A;  2EC3 A;  2O39 C;  4IGD A;  4PZ5 A;  1VVD A;  2X2Z A;  1GKN A;  2KMS A;  3F6K A;  1UOT P;  3INB C;  1TPM A;  3FGR A;  2JGW A;  4ZH1 D;  3FGT A;  5HYP A;  1Z92 B;  5I0Q B;  2Y8S A;  1TPN A;  3CAL A;  3SW0 X;  5DN5 A;  4LOT A;  3EJH A;  1HCC A;  4A5W B;  4JHS A;  4AYM A;  3IU3 I;  3ZD2 A;  1OJY A;  2ZYC A;  4AYE A;  4YNX A;  2YBY A;  3IX0 A;  1PPQ A;  4J38 B;  2RKY A;  5HYT B;  3WSX A;  1ELV A;  1RLH A;  1O9A A;  3ERB A;  1H2P P;  2RLQ A;  4B2S A;  4APL A;  2QY0 A;  4WJG 2;  2CKU A;  2XWJ I;  4F4O C;  1H2Q P;  4DJZ A;  1GKG A; 
#chains in the Genus database with same CATH homology
 4K12 A;  4KKD A;  1G4F A;  2XWB F;  2MCY A;  3OXU D;  2CG6 A;  4LOS A;  1E5G A;  3R62 A;  5HZP B;  2XRB A;  2JRA A;  3T5O A;  2EHF A;  3OED C;  2IZ3 A;  2XRD A;  1G4G A;  2RLP A;  1Q3X A;  2MCZ A;  4MUC A;  1NWV A;  2V8E A;  2ERJ A;  4B2R A;  1QGB A;  1VVC A;  5HYU B;  1HFI A;  1OK2 A;  2W81 A;  2CG7 A;  1OJV A;  1CKL A;  3RJ3 D;  1MD8 A;  1H03 P;  1TPG A;  2UWN A;  1QO6 A;  3KZJ A;  4CSY A;  1E8B A;  5JPM G;  2B5I D;  1HFH A;  1LY2 A;  3ZRZ A;  1GPZ A;  1GHQ B;  1SRZ A;  3O8E B;  1OK1 A;  1SS2 A;  2KRI A;  2IZ4 A;  1ZJK A;  1OK3 A;  3MQL A;  3ZD1 A;  1C1Z A;  1U5M A;  3M7P A;  3KXV A;  2BZM A;  1E88 A;  2RL0 A;  1FBR A;  2G7I A;  1QUB A;  3TVJ A;  3L89 M;  2A55 A;  4ONT D;  4AYD A;  2XQW C;  5FO8 C;  2WII C;  4AYI A;  3OP8 A;  2LOJ A;  2JGX A;  1OK9 A;  1OJW A;  4FXG G;  3GXE A;  4C16 A;  3GOV A;  1H04 P;  1MD7 A;  3NFP I;  2W80 A;  2RKZ A;  2YRA A;  2EC3 A;  2O39 C;  4IGD A;  4PZ5 A;  1VVD A;  1GKN A;  2KMS A;  1UOT P;  3INB C;  1TPM A;  2JGW A;  4ZH1 D;  5HYP A;  1Z92 B;  5I0Q B;  1TPN A;  3CAL A;  3SW0 X;  4LOT A;  3EJH A;  1HCC A;  4A5W B;  4JHS A;  4AYM A;  3IU3 I;  3ZD2 A;  1OJY A;  4AYE A;  4YNX A;  2YBY A;  3IX0 A;  1PPQ A;  4J38 B;  2RKY A;  5HYT B;  1ELV A;  1O9A A;  3ERB A;  1H2P P;  2RLQ A;  4B2S A;  2QY0 A;  4WJG 2;  2CKU A;  2XWJ I;  4F4O C;  1H2Q P;  4DJZ A;  1GKG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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