4B2RA

Solution structure of ccp modules 10-11 of complement factor h
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
126
structure length
126
Chain Sequence
EAAGERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Solution Structure of Ccp Modules 10-12 Illuminates Functional Architecture of the Complement Regulator, Factor H.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords COMPLEMENT FACTOR H
total genus 17
structure length 126
sequence length 126
ec nomenclature
pdb deposition date 2012-07-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4b2rA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4b2rA02
1VVDA 2JGWA 1HFHA 4CSYA 2CG6A 1OK2A 2XRBA 3M7PA 3R62A 3O8EB 1GHQB 2RKZA 1GPZA 4MUCA 1NWVA 1OJWA 2JRAA 2LOJA 2W80A 5HZPB 2MCZA 2WIIC 2IZ4A 1C1ZA 2G7IA 4F4OC 4PZ5A 1O9AA 2XWJI 4IGDA 5JPMG 2ERJA 1U5MA 4KKDA 2RLQA 2B5ID 1TPNA 1HFIA 1ZJKA 1QGBA 2YRAA 1H03P 3ZD2A 1OK9A 1CKLA 2W81A 1MD7A 1GKNA 1Z92B 4K12A 1G4GA 3GXEA 3SW0X 1G4FA 4YNXA 1SRZA 3RJ3D 1OJVA 4JHSA 2V8EA 3INBC 5I0QB 2XQWC 1OJYA 1H04P 3OEDC 1H2QP 1GKGA 2EHFA 5HYPA 4J38B 3OP8A 3NFPI 2IZ3A 1PPQA 2EC3A 1ELVA 1MD8A 2UWNA 5FO8C 2BZMA 4B2RA 4AYEA 2RL0A 1QO6A 1OK1A 1TPMA 2RKYA 2A55A 1Q3XA 2KMSA 4AYDA 2CKUA 2KRIA 1E5GA 3IU3I 4LOTA 2YBYA 3GOVA 5HYUB 5HYTB 4ZH1D 3KZJA 4LOSA 4ONTD 4FXGG 3ZRZA 3OXUD 4A5WB 3T5OA 1VVCA 2MCYA 1HCCA 1TPGA 2RLPA 3ERBA 3MQLA 4DJZA 2O39C 3TVJA 3CALA 2QY0A 2JGXA 1LY2A 3ZD1A 3EJHA 2XRDA 4AYIA 1E8BA 4C16A 4WJG2 1H2PP 3IX0A 1SS2A 2XWBF 1UOTP 3KXVA 4B2SA 1FBRA 3L89M 1E88A 1OK3A 2CG7A 1QUBA 4AYMA
chains in the Genus database with same CATH superfamily
1VVDA 2JGWA 1HFHA 4APLA 4PO7A 4CSYA 2CG6A 1OK2A 2XRBA 3M7PA 3R62A 3O8EB 1GHQB 2RKZA 1GPZA 4MUCA 3F6KA 1NWVA 1OJWA 2JRAA 2LOJA 2W80A 5HZPB 2MCZA 2WIIC 2I2LA 2IZ4A 4N7EA 1C1ZA 2G7IA 5DN4A 4F4OC 4PZ5A 1O9AA 2XWJI 4IGDA 5JPMG 2ERJA 1U5MA 4KKDA 3WSXA 2RLQA 3ZLDA 2B5ID 1TPNA 1HFIA 1ZJKA 1QGBA 5DN5A 2YRAA 2ZYCA 1H03P 3ZD2A 1OK9A 1CKLA 2W81A 1MD7A 1GKNA 1Z92B 4K12A 1G4GA 2Y8SA 3GXEA 3SW0X 1G4FA 4YNXA 3FGTA 1SRZA 2X2ZA 3RJ3D 1OJVA 3ZLEA 4JHSA 2V8EA 3INBC 5I0QB 2XQWC 1OJYA 1H04P 2Y8TA 3OEDC 1H2QP 1GKGA 2EHFA 3VWOA 5HYPA 4J38B 3WSYA 3OP8A 3NFPI 2IZ3A 4MSLA 1PPQA 2EC3A 1ELVA 1MD8A 2UWNA 5FO8C 2BZMA 4B2RA 4AYEA 2RL0A 1QO6A 1OK1A 1TPMA 2RKYA 2A55A 1Q3XA 2KMSA 3CI0J 2CKUA 2KRIA 4AYDA 1E5GA 3IU3I 4LOTA 2YBYA 3GOVA 5HYUB 5HYTB 4ZH1D 3KZJA 4LOSA 4ONTD 4FXGG 3ZRZA 3OXUD 4A5WB 3K3TA 3T5OA 1VVCA 2MCYA 1HCCA 1TPGA 2RLPA 2Y8RA 3ERBA 3MQLA 4DJZA 2O39C 3TVJA 3CALA 2QY0A 2JGXA 1LY2A 1RLHA 3ZD1A 3EJHA 3FGRA 2XRDA 4AYIA 3NJAA 1E8BA 4C16A 4YIZA 4WJG2 1H2PP 3IX0A 1SS2A 2XWBF 1UOTP 3KXVA 4B2SA 1FBRA 3L89M 1E88A 1OK3A 2CG7A 4BWCA 1QUBA 4AYMA
chains in the Genus database with same CATH topology
1VVDA 2JGWA 1HFHA 4CSYA 2CG6A 1OK2A 2XRBA 3M7PA 3R62A 3O8EB 1GHQB 2RKZA 1GPZA 4MUCA 1NWVA 1OJWA 2JRAA 2LOJA 2W80A 5HZPB 2MCZA 2WIIC 2IZ4A 1C1ZA 2G7IA 4F4OC 4PZ5A 1O9AA 2XWJI 4IGDA 5JPMG 2ERJA 1U5MA 4KKDA 2RLQA 2B5ID 1TPNA 1HFIA 1ZJKA 1QGBA 2YRAA 1H03P 3ZD2A 1OK9A 1CKLA 2W81A 1MD7A 1GKNA 1Z92B 4K12A 1G4GA 3GXEA 3SW0X 1G4FA 4YNXA 1SRZA 3RJ3D 1OJVA 4JHSA 2V8EA 3INBC 5I0QB 2XQWC 1OJYA 1H04P 3OEDC 1H2QP 1GKGA 2EHFA 5HYPA 4J38B 3OP8A 3NFPI 2IZ3A 1PPQA 2EC3A 1ELVA 1MD8A 2UWNA 5FO8C 2BZMA 4B2RA 4AYEA 2RL0A 1QO6A 1OK1A 1TPMA 2RKYA 2A55A 1Q3XA 2KMSA 4AYDA 2CKUA 2KRIA 1E5GA 3IU3I 4LOTA 2YBYA 3GOVA 5HYUB 5HYTB 4ZH1D 3KZJA 4LOSA 4ONTD 4FXGG 3ZRZA 3OXUD 4A5WB 3T5OA 1VVCA 2MCYA 1HCCA 1TPGA 2RLPA 3ERBA 3MQLA 4DJZA 2O39C 3TVJA 3CALA 2QY0A 2JGXA 1LY2A 3ZD1A 3EJHA 2XRDA 4AYIA 1E8BA 4C16A 4WJG2 1H2PP 3IX0A 1SS2A 2XWBF 1UOTP 3KXVA 4B2SA 1FBRA 3L89M 1E88A 1OK3A 2CG7A 1QUBA 4AYMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VVD A;  2JGW A;  1HFH A;  4CSY A;  2CG6 A;  1OK2 A;  2XRB A;  3M7P A;  3R62 A;  3O8E B;  1GHQ B;  2RKZ A;  1GPZ A;  4MUC A;  1NWV A;  1OJW A;  2JRA A;  2LOJ A;  2W80 A;  5HZP B;  2MCZ A;  2WII C;  2IZ4 A;  1C1Z A;  2G7I A;  4F4O C;  4PZ5 A;  1O9A A;  2XWJ I;  4IGD A;  5JPM G;  2ERJ A;  1U5M A;  4KKD A;  2RLQ A;  2B5I D;  1TPN A;  1HFI A;  1ZJK A;  1QGB A;  2YRA A;  1H03 P;  3ZD2 A;  1OK9 A;  1CKL A;  2W81 A;  1MD7 A;  1GKN A;  1Z92 B;  4K12 A;  1G4G A;  3GXE A;  3SW0 X;  1G4F A;  4YNX A;  1SRZ A;  3RJ3 D;  1OJV A;  4JHS A;  2V8E A;  3INB C;  5I0Q B;  2XQW C;  1OJY A;  1H04 P;  3OED C;  1H2Q P;  1GKG A;  2EHF A;  5HYP A;  4J38 B;  3OP8 A;  3NFP I;  2IZ3 A;  1PPQ A;  2EC3 A;  1ELV A;  1MD8 A;  2UWN A;  5FO8 C;  2BZM A;  4B2R A;  4AYE A;  2RL0 A;  1QO6 A;  1OK1 A;  1TPM A;  2RKY A;  2A55 A;  1Q3X A;  2KMS A;  4AYD A;  2CKU A;  2KRI A;  1E5G A;  3IU3 I;  4LOT A;  2YBY A;  3GOV A;  5HYU B;  5HYT B;  4ZH1 D;  3KZJ A;  4LOS A;  4ONT D;  4FXG G;  3ZRZ A;  3OXU D;  4A5W B;  3T5O A;  1VVC A;  2MCY A;  1HCC A;  1TPG A;  2RLP A;  3ERB A;  3MQL A;  4DJZ A;  2O39 C;  3TVJ A;  3CAL A;  2QY0 A;  2JGX A;  1LY2 A;  3ZD1 A;  3EJH A;  2XRD A;  4AYI A;  1E8B A;  4C16 A;  4WJG 2;  1H2P P;  3IX0 A;  1SS2 A;  2XWB F;  1UOT P;  3KXV A;  4B2S A;  1FBR A;  3L89 M;  1E88 A;  1OK3 A;  2CG7 A;  1QUB A;  4AYM A; 
#chains in the Genus database with same CATH topology
 1VVD A;  2JGW A;  1HFH A;  4APL A;  4PO7 A;  4CSY A;  2CG6 A;  1OK2 A;  2XRB A;  3M7P A;  3R62 A;  3O8E B;  1GHQ B;  2RKZ A;  1GPZ A;  4MUC A;  3F6K A;  1NWV A;  1OJW A;  2JRA A;  2LOJ A;  2W80 A;  5HZP B;  2MCZ A;  2WII C;  2I2L A;  2IZ4 A;  4N7E A;  1C1Z A;  2G7I A;  5DN4 A;  4F4O C;  4PZ5 A;  1O9A A;  2XWJ I;  4IGD A;  5JPM G;  2ERJ A;  1U5M A;  4KKD A;  3WSX A;  2RLQ A;  3ZLD A;  2B5I D;  1TPN A;  1HFI A;  1ZJK A;  1QGB A;  5DN5 A;  2YRA A;  2ZYC A;  1H03 P;  3ZD2 A;  1OK9 A;  1CKL A;  2W81 A;  1MD7 A;  1GKN A;  1Z92 B;  4K12 A;  1G4G A;  2Y8S A;  3GXE A;  3SW0 X;  1G4F A;  4YNX A;  3FGT A;  1SRZ A;  2X2Z A;  3RJ3 D;  1OJV A;  3ZLE A;  4JHS A;  2V8E A;  3INB C;  5I0Q B;  2XQW C;  1OJY A;  1H04 P;  2Y8T A;  3OED C;  1H2Q P;  1GKG A;  2EHF A;  3VWO A;  5HYP A;  4J38 B;  3WSY A;  3OP8 A;  3NFP I;  2IZ3 A;  4MSL A;  1PPQ A;  2EC3 A;  1ELV A;  1MD8 A;  2UWN A;  5FO8 C;  2BZM A;  4B2R A;  4AYE A;  2RL0 A;  1QO6 A;  1OK1 A;  1TPM A;  2RKY A;  2A55 A;  1Q3X A;  2KMS A;  3CI0 J;  2CKU A;  2KRI A;  4AYD A;  1E5G A;  3IU3 I;  4LOT A;  2YBY A;  3GOV A;  5HYU B;  5HYT B;  4ZH1 D;  3KZJ A;  4LOS A;  4ONT D;  4FXG G;  3ZRZ A;  3OXU D;  4A5W B;  3K3T A;  3T5O A;  1VVC A;  2MCY A;  1HCC A;  1TPG A;  2RLP A;  2Y8R A;  3ERB A;  3MQL A;  4DJZ A;  2O39 C;  3TVJ A;  3CAL A;  2QY0 A;  2JGX A;  1LY2 A;  1RLH A;  3ZD1 A;  3EJH A;  3FGR A;  2XRD A;  4AYI A;  3NJA A;  1E8B A;  4C16 A;  4YIZ A;  4WJG 2;  1H2P P;  3IX0 A;  1SS2 A;  2XWB F;  1UOT P;  3KXV A;  4B2S A;  1FBR A;  3L89 M;  1E88 A;  1OK3 A;  2CG7 A;  4BWC A;  1QUB A;  4AYM A; 
#chains in the Genus database with same CATH homology
 1VVD A;  2JGW A;  1HFH A;  4CSY A;  2CG6 A;  1OK2 A;  2XRB A;  3M7P A;  3R62 A;  3O8E B;  1GHQ B;  2RKZ A;  1GPZ A;  4MUC A;  1NWV A;  1OJW A;  2JRA A;  2LOJ A;  2W80 A;  5HZP B;  2MCZ A;  2WII C;  2IZ4 A;  1C1Z A;  2G7I A;  4F4O C;  4PZ5 A;  1O9A A;  2XWJ I;  4IGD A;  5JPM G;  2ERJ A;  1U5M A;  4KKD A;  2RLQ A;  2B5I D;  1TPN A;  1HFI A;  1ZJK A;  1QGB A;  2YRA A;  1H03 P;  3ZD2 A;  1OK9 A;  1CKL A;  2W81 A;  1MD7 A;  1GKN A;  1Z92 B;  4K12 A;  1G4G A;  3GXE A;  3SW0 X;  1G4F A;  4YNX A;  1SRZ A;  3RJ3 D;  1OJV A;  4JHS A;  2V8E A;  3INB C;  5I0Q B;  2XQW C;  1OJY A;  1H04 P;  3OED C;  1H2Q P;  1GKG A;  2EHF A;  5HYP A;  4J38 B;  3OP8 A;  3NFP I;  2IZ3 A;  1PPQ A;  2EC3 A;  1ELV A;  1MD8 A;  2UWN A;  5FO8 C;  2BZM A;  4B2R A;  4AYE A;  2RL0 A;  1QO6 A;  1OK1 A;  1TPM A;  2RKY A;  2A55 A;  1Q3X A;  2KMS A;  4AYD A;  2CKU A;  2KRI A;  1E5G A;  3IU3 I;  4LOT A;  2YBY A;  3GOV A;  5HYU B;  5HYT B;  4ZH1 D;  3KZJ A;  4LOS A;  4ONT D;  4FXG G;  3ZRZ A;  3OXU D;  4A5W B;  3T5O A;  1VVC A;  2MCY A;  1HCC A;  1TPG A;  2RLP A;  3ERB A;  3MQL A;  4DJZ A;  2O39 C;  3TVJ A;  3CAL A;  2QY0 A;  2JGX A;  1LY2 A;  3ZD1 A;  3EJH A;  2XRD A;  4AYI A;  1E8B A;  4C16 A;  4WJG 2;  1H2P P;  3IX0 A;  1SS2 A;  2XWB F;  1UOT P;  3KXV A;  4B2S A;  1FBR A;  3L89 M;  1E88 A;  1OK3 A;  2CG7 A;  1QUB A;  4AYM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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