4B2RA

Solution structure of ccp modules 10-11 of complement factor h
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
126
structure length
126
Chain Sequence
EAAGERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Solution Structure of Ccp Modules 10-12 Illuminates Functional Architecture of the Complement Regulator, Factor H.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords COMPLEMENT FACTOR H
total genus 17
structure length 126
sequence length 126
ec nomenclature
pdb deposition date 2012-07-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4b2rA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4b2rA02
2ERJA 2RLPA 2MCYA 2WIIC 1NWVA 1O9AA 3EJHA 2JRAA 1OK9A 4K12A 2IZ3A 2JGXA 3KZJA 5HYUB 4C16A 2W81A 2CG7A 3OEDC 5HYPA 2B5ID 1Q3XA 2XWBF 1UOTP 3RJ3D 1TPGA 2UWNA 1HFIA 3ERBA 2JGWA 1OJWA 2EC3A 4KKDA 2CG6A 2KMSA 1SS2A 1GKGA 1QUBA 1G4GA 1HCCA 1GPZA 4AYDA 1E8BA 1LY2A 4ONTD 4YNXA 1FBRA 4AYIA 1OJYA 4PZ5A 4J38B 2YRAA 3KXVA 3T5OA 2QY0A 2LOJA 2XWJI 4B2SA 1OK3A 2RKYA 1TPNA 4MUCA 4CSYA 1MD7A 1H2QP 1MD8A 2BZMA 1E88A 4LOSA 5JPMG 1H03P 1C1ZA 1VVDA 4AYMA 2G7IA 3CALA 5HZPB 1OJVA 2IZ4A 1ZJKA 4B2RA 3ZD1A 1PPQA 2MCZA 3M7PA 4LOTA 3SW0X 2W80A 1VVCA 1OK2A 1OK1A 2RLQA 1SRZA 2RL0A 4AYEA 4DJZA 3GOVA 3L89M 4F4OC 1CKLA 4WJG2 1TPMA 2EHFA 3TVJA 1E5GA 4ZH1D 1H04P 3INBC 3MQLA 3OP8A 5FO8C 1QGBA 2XQWC 1Z92B 2XRBA 3O8EB 2A55A 4A5WB 2CKUA 2YBYA 4FXGG 1GHQB 3NFPI 3GXEA 1QO6A 3IX0A 3ZRZA 5I0QB 1ELVA 2V8EA 1GKNA 1G4FA 2O39C 5HYTB 4IGDA 1H2PP 1U5MA 4JHSA 2RKZA 2KRIA 3IU3I 3ZD2A 3R62A 3OXUD 1HFHA 2XRDA
chains in the Genus database with same CATH superfamily
2ERJA 2RLPA 2MCYA 2WIIC 1NWVA 1O9AA 3EJHA 2JRAA 1OK9A 4K12A 4BWCA 2Y8RA 2IZ3A 2JGXA 3KZJA 5HYUB 4C16A 2W81A 2CG7A 3OEDC 5HYPA 2B5ID 1Q3XA 3FGRA 4YIZA 2XWBF 1UOTP 3RJ3D 1TPGA 2UWNA 1HFIA 3ERBA 2JGWA 1OJWA 2EC3A 4KKDA 2CG6A 2KMSA 3FGTA 1SS2A 1GKGA 1QUBA 1G4GA 1HCCA 1GPZA 4AYDA 1E8BA 3ZLEA 1LY2A 4ONTD 4YNXA 1FBRA 4AYIA 1OJYA 2I2LA 4PZ5A 4J38B 2ZYCA 2YRAA 3KXVA 3T5OA 2QY0A 2LOJA 2XWJI 4B2SA 1OK3A 2RKYA 1TPNA 4MUCA 4CSYA 3NJAA 1MD7A 1H2QP 1MD8A 3K3TA 2BZMA 1E88A 4LOSA 5JPMG 1H03P 4APLA 1C1ZA 1VVDA 4AYMA 2G7IA 3CALA 5HZPB 1OJVA 2IZ4A 1ZJKA 4MSLA 3ZD1A 4B2RA 1PPQA 2MCZA 3M7PA 4LOTA 3SW0X 2W80A 1VVCA 4PO7A 1OK2A 1OK1A 5DN4A 2RLQA 4N7EA 1SRZA 2RL0A 2Y8SA 4AYEA 4DJZA 3GOVA 3L89M 3CI0J 4F4OC 1CKLA 4WJG2 1TPMA 2EHFA 3TVJA 1E5GA 4ZH1D 1H04P 3INBC 3MQLA 3F6KA 3OP8A 5FO8C 1QGBA 2XQWC 1Z92B 2XRBA 3O8EB 2A55A 3WSYA 4A5WB 2CKUA 1RLHA 2YBYA 4FXGG 1GHQB 3NFPI 2Y8TA 3GXEA 1QO6A 3IX0A 3ZRZA 5I0QB 1ELVA 3VWOA 2V8EA 1GKNA 5DN5A 1G4FA 2X2ZA 2O39C 5HYTB 4IGDA 1H2PP 1U5MA 4JHSA 2RKZA 3WSXA 2KRIA 3IU3I 3ZD2A 3ZLDA 3R62A 3OXUD 1HFHA 2XRDA
chains in the Genus database with same CATH topology
2ERJA 2RLPA 2MCYA 2WIIC 1NWVA 1O9AA 3EJHA 2JRAA 1OK9A 4K12A 2IZ3A 2JGXA 3KZJA 5HYUB 4C16A 2W81A 2CG7A 3OEDC 5HYPA 2B5ID 1Q3XA 2XWBF 1UOTP 3RJ3D 1TPGA 2UWNA 1HFIA 3ERBA 2JGWA 1OJWA 2EC3A 4KKDA 2CG6A 2KMSA 1SS2A 1GKGA 1QUBA 1G4GA 1HCCA 1GPZA 4AYDA 1E8BA 1LY2A 4ONTD 4YNXA 1FBRA 4AYIA 1OJYA 4PZ5A 4J38B 2YRAA 3KXVA 3T5OA 2QY0A 2LOJA 2XWJI 4B2SA 1OK3A 2RKYA 1TPNA 4MUCA 4CSYA 1MD7A 1H2QP 1MD8A 2BZMA 1E88A 4LOSA 5JPMG 1H03P 1C1ZA 1VVDA 4AYMA 2G7IA 3CALA 5HZPB 1OJVA 2IZ4A 1ZJKA 4B2RA 3ZD1A 1PPQA 2MCZA 3M7PA 4LOTA 3SW0X 2W80A 1VVCA 1OK2A 1OK1A 2RLQA 1SRZA 2RL0A 4AYEA 4DJZA 3GOVA 3L89M 4F4OC 1CKLA 4WJG2 1TPMA 2EHFA 3TVJA 1E5GA 4ZH1D 1H04P 3INBC 3MQLA 3OP8A 5FO8C 1QGBA 2XQWC 1Z92B 2XRBA 3O8EB 2A55A 4A5WB 2CKUA 2YBYA 4FXGG 1GHQB 3NFPI 3GXEA 1QO6A 3IX0A 3ZRZA 5I0QB 1ELVA 2V8EA 1GKNA 1G4FA 2O39C 5HYTB 4IGDA 1H2PP 1U5MA 4JHSA 2RKZA 2KRIA 3IU3I 3ZD2A 3R62A 3OXUD 1HFHA 2XRDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ERJ A;  2RLP A;  2MCY A;  2WII C;  1NWV A;  1O9A A;  3EJH A;  2JRA A;  1OK9 A;  4K12 A;  2IZ3 A;  2JGX A;  3KZJ A;  5HYU B;  4C16 A;  2W81 A;  2CG7 A;  3OED C;  5HYP A;  2B5I D;  1Q3X A;  2XWB F;  1UOT P;  3RJ3 D;  1TPG A;  2UWN A;  1HFI A;  3ERB A;  2JGW A;  1OJW A;  2EC3 A;  4KKD A;  2CG6 A;  2KMS A;  1SS2 A;  1GKG A;  1QUB A;  1G4G A;  1HCC A;  1GPZ A;  4AYD A;  1E8B A;  1LY2 A;  4ONT D;  4YNX A;  1FBR A;  4AYI A;  1OJY A;  4PZ5 A;  4J38 B;  2YRA A;  3KXV A;  3T5O A;  2QY0 A;  2LOJ A;  2XWJ I;  4B2S A;  1OK3 A;  2RKY A;  1TPN A;  4MUC A;  4CSY A;  1MD7 A;  1H2Q P;  1MD8 A;  2BZM A;  1E88 A;  4LOS A;  5JPM G;  1H03 P;  1C1Z A;  1VVD A;  4AYM A;  2G7I A;  3CAL A;  5HZP B;  1OJV A;  2IZ4 A;  1ZJK A;  4B2R A;  3ZD1 A;  1PPQ A;  2MCZ A;  3M7P A;  4LOT A;  3SW0 X;  2W80 A;  1VVC A;  1OK2 A;  1OK1 A;  2RLQ A;  1SRZ A;  2RL0 A;  4AYE A;  4DJZ A;  3GOV A;  3L89 M;  4F4O C;  1CKL A;  4WJG 2;  1TPM A;  2EHF A;  3TVJ A;  1E5G A;  4ZH1 D;  1H04 P;  3INB C;  3MQL A;  3OP8 A;  5FO8 C;  1QGB A;  2XQW C;  1Z92 B;  2XRB A;  3O8E B;  2A55 A;  4A5W B;  2CKU A;  2YBY A;  4FXG G;  1GHQ B;  3NFP I;  3GXE A;  1QO6 A;  3IX0 A;  3ZRZ A;  5I0Q B;  1ELV A;  2V8E A;  1GKN A;  1G4F A;  2O39 C;  5HYT B;  4IGD A;  1H2P P;  1U5M A;  4JHS A;  2RKZ A;  2KRI A;  3IU3 I;  3ZD2 A;  3R62 A;  3OXU D;  1HFH A;  2XRD A; 
#chains in the Genus database with same CATH topology
 2ERJ A;  2RLP A;  2MCY A;  2WII C;  1NWV A;  1O9A A;  3EJH A;  2JRA A;  1OK9 A;  4K12 A;  4BWC A;  2Y8R A;  2IZ3 A;  2JGX A;  3KZJ A;  5HYU B;  4C16 A;  2W81 A;  2CG7 A;  3OED C;  5HYP A;  2B5I D;  1Q3X A;  3FGR A;  4YIZ A;  2XWB F;  1UOT P;  3RJ3 D;  1TPG A;  2UWN A;  1HFI A;  3ERB A;  2JGW A;  1OJW A;  2EC3 A;  4KKD A;  2CG6 A;  2KMS A;  3FGT A;  1SS2 A;  1GKG A;  1QUB A;  1G4G A;  1HCC A;  1GPZ A;  4AYD A;  1E8B A;  3ZLE A;  1LY2 A;  4ONT D;  4YNX A;  1FBR A;  4AYI A;  1OJY A;  2I2L A;  4PZ5 A;  4J38 B;  2ZYC A;  2YRA A;  3KXV A;  3T5O A;  2QY0 A;  2LOJ A;  2XWJ I;  4B2S A;  1OK3 A;  2RKY A;  1TPN A;  4MUC A;  4CSY A;  3NJA A;  1MD7 A;  1H2Q P;  1MD8 A;  3K3T A;  2BZM A;  1E88 A;  4LOS A;  5JPM G;  1H03 P;  4APL A;  1C1Z A;  1VVD A;  4AYM A;  2G7I A;  3CAL A;  5HZP B;  1OJV A;  2IZ4 A;  1ZJK A;  4MSL A;  3ZD1 A;  4B2R A;  1PPQ A;  2MCZ A;  3M7P A;  4LOT A;  3SW0 X;  2W80 A;  1VVC A;  4PO7 A;  1OK2 A;  1OK1 A;  5DN4 A;  2RLQ A;  4N7E A;  1SRZ A;  2RL0 A;  2Y8S A;  4AYE A;  4DJZ A;  3GOV A;  3L89 M;  3CI0 J;  4F4O C;  1CKL A;  4WJG 2;  1TPM A;  2EHF A;  3TVJ A;  1E5G A;  4ZH1 D;  1H04 P;  3INB C;  3MQL A;  3F6K A;  3OP8 A;  5FO8 C;  1QGB A;  2XQW C;  1Z92 B;  2XRB A;  3O8E B;  2A55 A;  3WSY A;  4A5W B;  2CKU A;  1RLH A;  2YBY A;  4FXG G;  1GHQ B;  3NFP I;  2Y8T A;  3GXE A;  1QO6 A;  3IX0 A;  3ZRZ A;  5I0Q B;  1ELV A;  3VWO A;  2V8E A;  1GKN A;  5DN5 A;  1G4F A;  2X2Z A;  2O39 C;  5HYT B;  4IGD A;  1H2P P;  1U5M A;  4JHS A;  2RKZ A;  3WSX A;  2KRI A;  3IU3 I;  3ZD2 A;  3ZLD A;  3R62 A;  3OXU D;  1HFH A;  2XRD A; 
#chains in the Genus database with same CATH homology
 2ERJ A;  2RLP A;  2MCY A;  2WII C;  1NWV A;  1O9A A;  3EJH A;  2JRA A;  1OK9 A;  4K12 A;  2IZ3 A;  2JGX A;  3KZJ A;  5HYU B;  4C16 A;  2W81 A;  2CG7 A;  3OED C;  5HYP A;  2B5I D;  1Q3X A;  2XWB F;  1UOT P;  3RJ3 D;  1TPG A;  2UWN A;  1HFI A;  3ERB A;  2JGW A;  1OJW A;  2EC3 A;  4KKD A;  2CG6 A;  2KMS A;  1SS2 A;  1GKG A;  1QUB A;  1G4G A;  1HCC A;  1GPZ A;  4AYD A;  1E8B A;  1LY2 A;  4ONT D;  4YNX A;  1FBR A;  4AYI A;  1OJY A;  4PZ5 A;  4J38 B;  2YRA A;  3KXV A;  3T5O A;  2QY0 A;  2LOJ A;  2XWJ I;  4B2S A;  1OK3 A;  2RKY A;  1TPN A;  4MUC A;  4CSY A;  1MD7 A;  1H2Q P;  1MD8 A;  2BZM A;  1E88 A;  4LOS A;  5JPM G;  1H03 P;  1C1Z A;  1VVD A;  4AYM A;  2G7I A;  3CAL A;  5HZP B;  1OJV A;  2IZ4 A;  1ZJK A;  4B2R A;  3ZD1 A;  1PPQ A;  2MCZ A;  3M7P A;  4LOT A;  3SW0 X;  2W80 A;  1VVC A;  1OK2 A;  1OK1 A;  2RLQ A;  1SRZ A;  2RL0 A;  4AYE A;  4DJZ A;  3GOV A;  3L89 M;  4F4O C;  1CKL A;  4WJG 2;  1TPM A;  2EHF A;  3TVJ A;  1E5G A;  4ZH1 D;  1H04 P;  3INB C;  3MQL A;  3OP8 A;  5FO8 C;  1QGB A;  2XQW C;  1Z92 B;  2XRB A;  3O8E B;  2A55 A;  4A5W B;  2CKU A;  2YBY A;  4FXG G;  1GHQ B;  3NFP I;  3GXE A;  1QO6 A;  3IX0 A;  3ZRZ A;  5I0Q B;  1ELV A;  2V8E A;  1GKN A;  1G4F A;  2O39 C;  5HYT B;  4IGD A;  1H2P P;  1U5M A;  4JHS A;  2RKZ A;  2KRI A;  3IU3 I;  3ZD2 A;  3R62 A;  3OXU D;  1HFH A;  2XRD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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