4FFXA

Structural and biochemical characterization of human adenylosuccinate lyase (adsl) and the r303c adsl deficiency associated mutation
Total Genus 156
50100150200250300350400450020406080100120140160
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
156
sequence length
469
structure length
457
Chain Sequence
DHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIREMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYES
50100150200250300350400450400300200100
050100150Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTI1 (9-12)TIV3 (19-22)TI2 (15-18)TI3 (16-19)TIV1 (17-20)AH1 (24-30)AH3 (59-68)AH2 (32-53)TII2 (107-110)AH9 (216-230)TI'2 (212-215)TI4 (68-71)AH4 (74-84)AH5 (87-98)TI5 (99-102)TI6 (100-103)TI7 (102-105)TI8 (103-106)TI10 (200-203)TII1 (105-108)AH6 (112-149)TVIII1 (236-239)TIV5 (239-242)AH11 (299-324)AH7 (168-192)AH12 (333-360)3H1 (437-439)S2 (161-167)TI9 (149-152)S1 (153-158)AH10 (245-275)AH8 (206-212)TII'1 (326-329)AH15 (396-416)S4 (363-364)AH14 (381-389)TI11 (376-379)TIV7 (390-393)TI14 (430-433)TI15 (433-436)AH17 (440-444)3H2 (446-449)AH18 (452-469)O1 (55-57)AH13 (366-375)TIV6 (389-392)AH16 (422-429)Updating...
connected with : NaN
molecule tags Lyase
source organism Homo sapiens
publication title Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation.
pubmed doi rcsb
molecule keywords Adenylosuccinate lyase
total genus 156
structure length 457
sequence length 469
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2012-06-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4ffxA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4ffxA02
2PTSA 4V2QA 1AUWA 3TV2A 2O7FA 2RJRA 1K7WA 4EEIA 1TJWA 5F92A 1FUOA 3QBPA 1TJUA 2O7DA 1W27A 4FFXA 1GK3A 1YISA 1GKMA 2X75A 1TJVA 2QGAB 4APAA 1T6PA 3RRPA 4C5UA 1C3CA 1GKJA 1XWOA 1GK2A 4MX2A 3KDYA 4ADLA 3GZHA 1JSWA 1C3UA 1VDKA 2O7EA 4ADMA 3CZOA 3RD8A 4C6GA 2E9FA 3GTDA 3OCEA 3R6QA 1K62A 4HGVA 3UNVA 3KDZA 4CQ5A 4V2RA 3BHGA 2PFMA 4C5RA 3R6VA 5F91A 4NLEA 1DOFA 4FLCA 3R6YA 4BABA 1EB4A 1RE5A 2O78A 1U15A 1TJ7A 4NSLA 4C5SA 1J3UA 1HY1A 3OCFA 1YFMA 1U16A 2VD6A 2NYNA 4EFCA 1I0AA 2QVEA 2NYFA 3C8TA 1T6JA 3E04A 4BAAA 1FURA 1YFEA 1B8FA 1FUQA 5EYTA 1Q5NA 1KQ7A 2HVGA 2PTQA 2PTRA 5D6BA 2RJSA 3NZ4A 5EYVA 2O6YA 3NO9A 2FUSA 1FUPA 1Y2MA 4APBA 1DCNA 5HW2A 1HY0A 2O7BA 2OHYA 2YIIA 2J91A
chains in the Genus database with same CATH superfamily
2PTSA 4V2QA 1AUWA 3TV2A 1XMDA 2O7FA 2RJRA 1K7WA 4EEIA 1TJWA 5F92A 1FUOA 3QBPA 1TJUA 2O7DA 1W27A 4FFXA 1GK3A 1YISA 1GKMA 2X75A 1TJVA 2QGAB 4APAA 1T6PA 3RRPA 4WNLA 1XLYA 2VL7A 4C5UA 1C3CA 1GKJA 1XWOA 1GK2A 4MX2A 3KDYA 4ADLA 3GZHA 1JSWA 3CRW1 1C3UA 1VDKA 2O7EA 4ADMA 3CZOA 3RD8A 4C6GA 2E9FA 3GTDA 3OCEA 3R6QA 1K62A 4HGVA 4A15A 3UNVA 3KDZA 4CQ5A 4V2RA 3BHGA 2PFMA 4C5RA 3R6VA 5F91A 4NLEA 1DOFA 2VSFA 4FLCA 3R6YA 4BABA 1EB4A 1RE5A 2O78A 1U15A 1TJ7A 4NSLA 4C5SA 1J3UA 2FENA 1HY1A 3OCFA 1YFMA 1U16A 2VD6A 2NYNA 4EFCA 1I0AA 2QVEA 1XMCA 2NYFA 3C8TA 1T6JA 3E04A 4BAAA 1FURA 2FELA 1YFEA 1XL7A 5M0JA 1B8FA 1FUQA 5EYTA 1Q5NA 1KQ7A 5M0IA 3CRVA 2HVGA 2PTQA 2PTRA 5D6BA 2RJSA 3NZ4A 5EYVA 2O6YA 1XL8A 3NO9A 5H8WA 2FUSA 1FUPA 1Y2MA 4APBA 1DCNA 5HW2A 1HY0A 2O7BA 2OHYA 2YIIA 2J91A
chains in the Genus database with same CATH topology
2PTSA 4V2QA 1AUWA 3TV2A 2O7FA 2RJRA 1K7WA 4EEIA 1TJWA 5F92A 1FUOA 3QBPA 1TJUA 2O7DA 1W27A 4FFXA 1GK3A 1YISA 1GKMA 2X75A 1TJVA 2QGAB 4APAA 1T6PA 3RRPA 4C5UA 1C3CA 1GKJA 1XWOA 1GK2A 4MX2A 3KDYA 4ADLA 3GZHA 1JSWA 1C3UA 1VDKA 2O7EA 4ADMA 3CZOA 3RD8A 4C6GA 2E9FA 3GTDA 3OCEA 3R6QA 1K62A 4HGVA 3UNVA 3KDZA 4CQ5A 4V2RA 3BHGA 2PFMA 4C5RA 3R6VA 5F91A 4NLEA 1DOFA 4FLCA 3R6YA 4BABA 1EB4A 1RE5A 2O78A 1U15A 1TJ7A 4NSLA 4C5SA 1J3UA 1HY1A 3OCFA 1YFMA 1U16A 2VD6A 2NYNA 4EFCA 1I0AA 2QVEA 2NYFA 3C8TA 1T6JA 3E04A 4BAAA 1FURA 1YFEA 1B8FA 1FUQA 5EYTA 1Q5NA 1KQ7A 2HVGA 2PTQA 2PTRA 5D6BA 2RJSA 3NZ4A 5EYVA 2O6YA 3NO9A 2FUSA 1FUPA 1Y2MA 4APBA 1DCNA 5HW2A 1HY0A 2O7BA 2OHYA 2YIIA 2J91A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PTS A;  4V2Q A;  1AUW A;  3TV2 A;  2O7F A;  2RJR A;  1K7W A;  4EEI A;  1TJW A;  5F92 A;  1FUO A;  3QBP A;  1TJU A;  2O7D A;  1W27 A;  4FFX A;  1GK3 A;  1YIS A;  1GKM A;  2X75 A;  1TJV A;  2QGA B;  4APA A;  1T6P A;  3RRP A;  4C5U A;  1C3C A;  1GKJ A;  1XWO A;  1GK2 A;  4MX2 A;  3KDY A;  4ADL A;  3GZH A;  1JSW A;  1C3U A;  1VDK A;  2O7E A;  4ADM A;  3CZO A;  3RD8 A;  4C6G A;  2E9F A;  3GTD A;  3OCE A;  3R6Q A;  1K62 A;  4HGV A;  3UNV A;  3KDZ A;  4CQ5 A;  4V2R A;  3BHG A;  2PFM A;  4C5R A;  3R6V A;  5F91 A;  4NLE A;  1DOF A;  4FLC A;  3R6Y A;  4BAB A;  1EB4 A;  1RE5 A;  2O78 A;  1U15 A;  1TJ7 A;  4NSL A;  4C5S A;  1J3U A;  1HY1 A;  3OCF A;  1YFM A;  1U16 A;  2VD6 A;  2NYN A;  4EFC A;  1I0A A;  2QVE A;  2NYF A;  3C8T A;  1T6J A;  3E04 A;  4BAA A;  1FUR A;  1YFE A;  1B8F A;  1FUQ A;  5EYT A;  1Q5N A;  1KQ7 A;  2HVG A;  2PTQ A;  2PTR A;  5D6B A;  2RJS A;  3NZ4 A;  5EYV A;  2O6Y A;  3NO9 A;  2FUS A;  1FUP A;  1Y2M A;  4APB A;  1DCN A;  5HW2 A;  1HY0 A;  2O7B A;  2OHY A;  2YII A;  2J91 A; 
#chains in the Genus database with same CATH topology
 2PTS A;  4V2Q A;  1AUW A;  3TV2 A;  1XMD A;  2O7F A;  2RJR A;  1K7W A;  4EEI A;  1TJW A;  5F92 A;  1FUO A;  3QBP A;  1TJU A;  2O7D A;  1W27 A;  4FFX A;  1GK3 A;  1YIS A;  1GKM A;  2X75 A;  1TJV A;  2QGA B;  4APA A;  1T6P A;  3RRP A;  4WNL A;  1XLY A;  2VL7 A;  4C5U A;  1C3C A;  1GKJ A;  1XWO A;  1GK2 A;  4MX2 A;  3KDY A;  4ADL A;  3GZH A;  1JSW A;  3CRW 1;  1C3U A;  1VDK A;  2O7E A;  4ADM A;  3CZO A;  3RD8 A;  4C6G A;  2E9F A;  3GTD A;  3OCE A;  3R6Q A;  1K62 A;  4HGV A;  4A15 A;  3UNV A;  3KDZ A;  4CQ5 A;  4V2R A;  3BHG A;  2PFM A;  4C5R A;  3R6V A;  5F91 A;  4NLE A;  1DOF A;  2VSF A;  4FLC A;  3R6Y A;  4BAB A;  1EB4 A;  1RE5 A;  2O78 A;  1U15 A;  1TJ7 A;  4NSL A;  4C5S A;  1J3U A;  2FEN A;  1HY1 A;  3OCF A;  1YFM A;  1U16 A;  2VD6 A;  2NYN A;  4EFC A;  1I0A A;  2QVE A;  1XMC A;  2NYF A;  3C8T A;  1T6J A;  3E04 A;  4BAA A;  1FUR A;  2FEL A;  1YFE A;  1XL7 A;  5M0J A;  1B8F A;  1FUQ A;  5EYT A;  1Q5N A;  1KQ7 A;  5M0I A;  3CRV A;  2HVG A;  2PTQ A;  2PTR A;  5D6B A;  2RJS A;  3NZ4 A;  5EYV A;  2O6Y A;  1XL8 A;  3NO9 A;  5H8W A;  2FUS A;  1FUP A;  1Y2M A;  4APB A;  1DCN A;  5HW2 A;  1HY0 A;  2O7B A;  2OHY A;  2YII A;  2J91 A; 
#chains in the Genus database with same CATH homology
 2PTS A;  4V2Q A;  1AUW A;  3TV2 A;  2O7F A;  2RJR A;  1K7W A;  4EEI A;  1TJW A;  5F92 A;  1FUO A;  3QBP A;  1TJU A;  2O7D A;  1W27 A;  4FFX A;  1GK3 A;  1YIS A;  1GKM A;  2X75 A;  1TJV A;  2QGA B;  4APA A;  1T6P A;  3RRP A;  4C5U A;  1C3C A;  1GKJ A;  1XWO A;  1GK2 A;  4MX2 A;  3KDY A;  4ADL A;  3GZH A;  1JSW A;  1C3U A;  1VDK A;  2O7E A;  4ADM A;  3CZO A;  3RD8 A;  4C6G A;  2E9F A;  3GTD A;  3OCE A;  3R6Q A;  1K62 A;  4HGV A;  3UNV A;  3KDZ A;  4CQ5 A;  4V2R A;  3BHG A;  2PFM A;  4C5R A;  3R6V A;  5F91 A;  4NLE A;  1DOF A;  4FLC A;  3R6Y A;  4BAB A;  1EB4 A;  1RE5 A;  2O78 A;  1U15 A;  1TJ7 A;  4NSL A;  4C5S A;  1J3U A;  1HY1 A;  3OCF A;  1YFM A;  1U16 A;  2VD6 A;  2NYN A;  4EFC A;  1I0A A;  2QVE A;  2NYF A;  3C8T A;  1T6J A;  3E04 A;  4BAA A;  1FUR A;  1YFE A;  1B8F A;  1FUQ A;  5EYT A;  1Q5N A;  1KQ7 A;  2HVG A;  2PTQ A;  2PTR A;  5D6B A;  2RJS A;  3NZ4 A;  5EYV A;  2O6Y A;  3NO9 A;  2FUS A;  1FUP A;  1Y2M A;  4APB A;  1DCN A;  5HW2 A;  1HY0 A;  2O7B A;  2OHY A;  2YII A;  2J91 A; 
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