4FXGG

Complement c4 in complex with masp-2
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
145
structure length
145
Chain Sequence
TAHACPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSART
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for activation of the complement system by component C4 cleavage.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement C4 beta chain
total genus 21
structure length 145
sequence length 145
chains with identical sequence I
ec nomenclature ec 3.4.21.104: Mannan-binding lectin-associated serine protease-2.
pdb deposition date 2012-07-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4fxgG02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4fxgG01
1CKLA 2UWNA 4AYIA 1OJYA 1VVCA 1OK3A 1GKNA 2MCZA 3L89M 1G4FA 1TPMA 1HFHA 5FO8C 2O39C 4J38B 1HCCA 4YNXA 3EJHA 1U5MA 1H2QP 3OXUD 4CSYA 3KZJA 4A5WB 1TPGA 4AYDA 1G4GA 1ELVA 1Z92B 2YBYA 2XWBF 4AYEA 2BZMA 2MCYA 2RL0A 5HYTB 4LOSA 1H04P 2W81A 2XRDA 1H03P 1H2PP 1OK2A 4B2RA 3ZD1A 1QUBA 2EHFA 3O8EB 3KXVA 4MUCA 1HFIA 1Q3XA 2A55A 1GPZA 3ERBA 3INBC 3GOVA 3IX0A 1E5GA 2JRAA 3ZRZA 2RLPA 1E88A 2JGXA 2IZ4A 3M7PA 1O9AA 3R62A 2B5ID 2CKUA 2G7IA 3SW0X 4PZ5A 4ONTD 5HZPB 3RJ3D 4C16A 2XQWC 2V8EA 1OK1A 2ERJA 5HYUB 1QGBA 2KMSA 4JHSA 5I0QB 5JPMG 1GHQB 3MQLA 2LOJA 4KKDA 3CALA 4ZH1D 2RKYA 4IGDA 3TVJA 1MD7A 2QY0A 2KRIA 2IZ3A 1LY2A 2W80A 4WJG2 1PPQA 3IU3I 3T5OA 4FXGG 1GKGA 1VVDA 4AYMA 1SRZA 2RKZA 1OK9A 4DJZA 5HYPA 3OP8A 1MD8A 3NFPI 4K12A 2RLQA 3ZD2A 2XWJI 1OJWA 4B2SA 1ZJKA 1UOTP 1NWVA 3GXEA 2EC3A 1OJVA 1SS2A 4F4OC 2XRBA 2JGWA 1FBRA 1TPNA 2WIIC 1QO6A 2CG6A 4LOTA 1C1ZA 2CG7A 1E8BA 2YRAA 3OEDC
chains in the Genus database with same CATH superfamily
1CKLA 3F6KA 2UWNA 4AYIA 1OJYA 1VVCA 1OK3A 2ZYCA 1GKNA 2MCZA 3L89M 1G4FA 1TPMA 1HFHA 5FO8C 2O39C 4J38B 1HCCA 4YNXA 3EJHA 4BWCA 1U5MA 1H2QP 3OXUD 4CSYA 3KZJA 4A5WB 1TPGA 4AYDA 1G4GA 1ELVA 1Z92B 2YBYA 2XWBF 4AYEA 2BZMA 2MCYA 2RL0A 5HYTB 4LOSA 1H04P 2W81A 2XRDA 1H03P 3WSYA 3CI0J 1H2PP 1OK2A 4B2RA 3ZD1A 1QUBA 2EHFA 3O8EB 3KXVA 4MUCA 1HFIA 1Q3XA 2A55A 1GPZA 4APLA 3ERBA 3INBC 3GOVA 3IX0A 1E5GA 2JRAA 5DN5A 3ZRZA 2RLPA 1E88A 2JGXA 2IZ4A 3M7PA 1O9AA 3R62A 2B5ID 2CKUA 2G7IA 3SW0X 4PZ5A 4ONTD 5HZPB 3RJ3D 4C16A 2XQWC 2V8EA 4YIZA 1OK1A 2ERJA 5HYUB 1QGBA 2KMSA 2Y8TA 4JHSA 2X2ZA 5I0QB 5JPMG 1GHQB 3MQLA 2LOJA 4KKDA 2Y8SA 3CALA 4ZH1D 2RKYA 4IGDA 3TVJA 3VWOA 1MD7A 2QY0A 2KRIA 2IZ3A 3FGTA 1LY2A 2W80A 4WJG2 1PPQA 3IU3I 3T5OA 4FXGG 3ZLDA 1RLHA 1GKGA 1VVDA 4MSLA 4AYMA 1SRZA 2RKZA 2I2LA 1OK9A 4DJZA 2Y8RA 5HYPA 3OP8A 1MD8A 3NFPI 4K12A 2RLQA 3ZD2A 2XWJI 1OJWA 4B2SA 1ZJKA 1UOTP 3WSXA 1NWVA 3GXEA 2EC3A 1OJVA 1SS2A 3FGRA 4F4OC 3K3TA 2XRBA 2JGWA 1FBRA 1TPNA 2WIIC 4PO7A 3ZLEA 1QO6A 2CG6A 4LOTA 1C1ZA 2CG7A 4N7EA 5DN4A 1E8BA 3NJAA 2YRAA 3OEDC
chains in the Genus database with same CATH topology
1CKLA 2UWNA 4AYIA 1OJYA 1VVCA 1OK3A 1GKNA 2MCZA 3L89M 1G4FA 1TPMA 1HFHA 5FO8C 2O39C 4J38B 1HCCA 4YNXA 3EJHA 1U5MA 1H2QP 3OXUD 4CSYA 3KZJA 4A5WB 1TPGA 4AYDA 1G4GA 1ELVA 1Z92B 2YBYA 2XWBF 4AYEA 2BZMA 2MCYA 2RL0A 5HYTB 4LOSA 1H04P 2W81A 2XRDA 1H03P 1H2PP 1OK2A 4B2RA 3ZD1A 1QUBA 2EHFA 3O8EB 3KXVA 4MUCA 1HFIA 1Q3XA 2A55A 1GPZA 3ERBA 3INBC 3GOVA 3IX0A 1E5GA 2JRAA 3ZRZA 2RLPA 1E88A 2JGXA 2IZ4A 3M7PA 1O9AA 3R62A 2B5ID 2CKUA 2G7IA 3SW0X 4PZ5A 4ONTD 5HZPB 3RJ3D 4C16A 2XQWC 2V8EA 1OK1A 2ERJA 5HYUB 1QGBA 2KMSA 4JHSA 5I0QB 5JPMG 1GHQB 3MQLA 2LOJA 4KKDA 3CALA 4ZH1D 2RKYA 4IGDA 3TVJA 1MD7A 2QY0A 2KRIA 2IZ3A 1LY2A 2W80A 4WJG2 1PPQA 3IU3I 3T5OA 4FXGG 1GKGA 1VVDA 4AYMA 1SRZA 2RKZA 1OK9A 4DJZA 5HYPA 3OP8A 1MD8A 3NFPI 4K12A 2RLQA 3ZD2A 2XWJI 1OJWA 4B2SA 1ZJKA 1UOTP 1NWVA 3GXEA 2EC3A 1OJVA 1SS2A 4F4OC 2XRBA 2JGWA 1FBRA 1TPNA 2WIIC 1QO6A 2CG6A 4LOTA 1C1ZA 2CG7A 1E8BA 2YRAA 3OEDC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CKL A;  2UWN A;  4AYI A;  1OJY A;  1VVC A;  1OK3 A;  1GKN A;  2MCZ A;  3L89 M;  1G4F A;  1TPM A;  1HFH A;  5FO8 C;  2O39 C;  4J38 B;  1HCC A;  4YNX A;  3EJH A;  1U5M A;  1H2Q P;  3OXU D;  4CSY A;  3KZJ A;  4A5W B;  1TPG A;  4AYD A;  1G4G A;  1ELV A;  1Z92 B;  2YBY A;  2XWB F;  4AYE A;  2BZM A;  2MCY A;  2RL0 A;  5HYT B;  4LOS A;  1H04 P;  2W81 A;  2XRD A;  1H03 P;  1H2P P;  1OK2 A;  4B2R A;  3ZD1 A;  1QUB A;  2EHF A;  3O8E B;  3KXV A;  4MUC A;  1HFI A;  1Q3X A;  2A55 A;  1GPZ A;  3ERB A;  3INB C;  3GOV A;  3IX0 A;  1E5G A;  2JRA A;  3ZRZ A;  2RLP A;  1E88 A;  2JGX A;  2IZ4 A;  3M7P A;  1O9A A;  3R62 A;  2B5I D;  2CKU A;  2G7I A;  3SW0 X;  4PZ5 A;  4ONT D;  5HZP B;  3RJ3 D;  4C16 A;  2XQW C;  2V8E A;  1OK1 A;  2ERJ A;  5HYU B;  1QGB A;  2KMS A;  4JHS A;  5I0Q B;  5JPM G;  1GHQ B;  3MQL A;  2LOJ A;  4KKD A;  3CAL A;  4ZH1 D;  2RKY A;  4IGD A;  3TVJ A;  1MD7 A;  2QY0 A;  2KRI A;  2IZ3 A;  1LY2 A;  2W80 A;  4WJG 2;  1PPQ A;  3IU3 I;  3T5O A;  4FXG G;  1GKG A;  1VVD A;  4AYM A;  1SRZ A;  2RKZ A;  1OK9 A;  4DJZ A;  5HYP A;  3OP8 A;  1MD8 A;  3NFP I;  4K12 A;  2RLQ A;  3ZD2 A;  2XWJ I;  1OJW A;  4B2S A;  1ZJK A;  1UOT P;  1NWV A;  3GXE A;  2EC3 A;  1OJV A;  1SS2 A;  4F4O C;  2XRB A;  2JGW A;  1FBR A;  1TPN A;  2WII C;  1QO6 A;  2CG6 A;  4LOT A;  1C1Z A;  2CG7 A;  1E8B A;  2YRA A;  3OED C; 
#chains in the Genus database with same CATH topology
 1CKL A;  3F6K A;  2UWN A;  4AYI A;  1OJY A;  1VVC A;  1OK3 A;  2ZYC A;  1GKN A;  2MCZ A;  3L89 M;  1G4F A;  1TPM A;  1HFH A;  5FO8 C;  2O39 C;  4J38 B;  1HCC A;  4YNX A;  3EJH A;  4BWC A;  1U5M A;  1H2Q P;  3OXU D;  4CSY A;  3KZJ A;  4A5W B;  1TPG A;  4AYD A;  1G4G A;  1ELV A;  1Z92 B;  2YBY A;  2XWB F;  4AYE A;  2BZM A;  2MCY A;  2RL0 A;  5HYT B;  4LOS A;  1H04 P;  2W81 A;  2XRD A;  1H03 P;  3WSY A;  3CI0 J;  1H2P P;  1OK2 A;  4B2R A;  3ZD1 A;  1QUB A;  2EHF A;  3O8E B;  3KXV A;  4MUC A;  1HFI A;  1Q3X A;  2A55 A;  1GPZ A;  4APL A;  3ERB A;  3INB C;  3GOV A;  3IX0 A;  1E5G A;  2JRA A;  5DN5 A;  3ZRZ A;  2RLP A;  1E88 A;  2JGX A;  2IZ4 A;  3M7P A;  1O9A A;  3R62 A;  2B5I D;  2CKU A;  2G7I A;  3SW0 X;  4PZ5 A;  4ONT D;  5HZP B;  3RJ3 D;  4C16 A;  2XQW C;  2V8E A;  4YIZ A;  1OK1 A;  2ERJ A;  5HYU B;  1QGB A;  2KMS A;  2Y8T A;  4JHS A;  2X2Z A;  5I0Q B;  5JPM G;  1GHQ B;  3MQL A;  2LOJ A;  4KKD A;  2Y8S A;  3CAL A;  4ZH1 D;  2RKY A;  4IGD A;  3TVJ A;  3VWO A;  1MD7 A;  2QY0 A;  2KRI A;  2IZ3 A;  3FGT A;  1LY2 A;  2W80 A;  4WJG 2;  1PPQ A;  3IU3 I;  3T5O A;  4FXG G;  3ZLD A;  1RLH A;  1GKG A;  1VVD A;  4MSL A;  4AYM A;  1SRZ A;  2RKZ A;  2I2L A;  1OK9 A;  4DJZ A;  2Y8R A;  5HYP A;  3OP8 A;  1MD8 A;  3NFP I;  4K12 A;  2RLQ A;  3ZD2 A;  2XWJ I;  1OJW A;  4B2S A;  1ZJK A;  1UOT P;  3WSX A;  1NWV A;  3GXE A;  2EC3 A;  1OJV A;  1SS2 A;  3FGR A;  4F4O C;  3K3T A;  2XRB A;  2JGW A;  1FBR A;  1TPN A;  2WII C;  4PO7 A;  3ZLE A;  1QO6 A;  2CG6 A;  4LOT A;  1C1Z A;  2CG7 A;  4N7E A;  5DN4 A;  1E8B A;  3NJA A;  2YRA A;  3OED C; 
#chains in the Genus database with same CATH homology
 1CKL A;  2UWN A;  4AYI A;  1OJY A;  1VVC A;  1OK3 A;  1GKN A;  2MCZ A;  3L89 M;  1G4F A;  1TPM A;  1HFH A;  5FO8 C;  2O39 C;  4J38 B;  1HCC A;  4YNX A;  3EJH A;  1U5M A;  1H2Q P;  3OXU D;  4CSY A;  3KZJ A;  4A5W B;  1TPG A;  4AYD A;  1G4G A;  1ELV A;  1Z92 B;  2YBY A;  2XWB F;  4AYE A;  2BZM A;  2MCY A;  2RL0 A;  5HYT B;  4LOS A;  1H04 P;  2W81 A;  2XRD A;  1H03 P;  1H2P P;  1OK2 A;  4B2R A;  3ZD1 A;  1QUB A;  2EHF A;  3O8E B;  3KXV A;  4MUC A;  1HFI A;  1Q3X A;  2A55 A;  1GPZ A;  3ERB A;  3INB C;  3GOV A;  3IX0 A;  1E5G A;  2JRA A;  3ZRZ A;  2RLP A;  1E88 A;  2JGX A;  2IZ4 A;  3M7P A;  1O9A A;  3R62 A;  2B5I D;  2CKU A;  2G7I A;  3SW0 X;  4PZ5 A;  4ONT D;  5HZP B;  3RJ3 D;  4C16 A;  2XQW C;  2V8E A;  1OK1 A;  2ERJ A;  5HYU B;  1QGB A;  2KMS A;  4JHS A;  5I0Q B;  5JPM G;  1GHQ B;  3MQL A;  2LOJ A;  4KKD A;  3CAL A;  4ZH1 D;  2RKY A;  4IGD A;  3TVJ A;  1MD7 A;  2QY0 A;  2KRI A;  2IZ3 A;  1LY2 A;  2W80 A;  4WJG 2;  1PPQ A;  3IU3 I;  3T5O A;  4FXG G;  1GKG A;  1VVD A;  4AYM A;  1SRZ A;  2RKZ A;  1OK9 A;  4DJZ A;  5HYP A;  3OP8 A;  1MD8 A;  3NFP I;  4K12 A;  2RLQ A;  3ZD2 A;  2XWJ I;  1OJW A;  4B2S A;  1ZJK A;  1UOT P;  1NWV A;  3GXE A;  2EC3 A;  1OJV A;  1SS2 A;  4F4O C;  2XRB A;  2JGW A;  1FBR A;  1TPN A;  2WII C;  1QO6 A;  2CG6 A;  4LOT A;  1C1Z A;  2CG7 A;  1E8B A;  2YRA A;  3OED C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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