4K12A

Structural basis for host specificity of factor h binding by streptococcus pneumoniae
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
64
structure length
64
Chain Sequence
GSHMSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae.
pubmed doi rcsb
molecule tags Immune system/choline binding protein
source organism Homo sapiens
molecule keywords Complement factor H
total genus 11
structure length 64
sequence length 64
ec nomenclature
pdb deposition date 2013-04-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4k12A00
3MQLA 2WIIC 4C16A 3OEDC 4ZH1D 1OK1A 2EC3A 1GPZA 1UOTP 3RJ3D 3ZD1A 1Z92B 1FBRA 3KZJA 1TPMA 2IZ4A 2A55A 3ERBA 3IX0A 5I0QB 1H04P 1SS2A 4PZ5A 2ERJA 2QY0A 4MUCA 5JPMG 1ZJKA 2CG6A 1LY2A 3O8EB 2RKZA 3TVJA 1VVDA 4AYIA 3OXUD 3ZRZA 2G7IA 2CKUA 2KMSA 2JRAA 4ONTD 5HYUB 2JGXA 1SRZA 3EJHA 1C1ZA 1TPNA 1H2PP 1GKGA 1CKLA 1OK2A 2JGWA 3GOVA 2W81A 4A5WB 5HYPA 1NWVA 1OJWA 1MD7A 1OK9A 2XQWC 4AYEA 4IGDA 1TPGA 1OJYA 1Q3XA 2BZMA 1O9AA 1VVCA 4FXGG 2RLPA 1HFIA 1OK3A 2W80A 2CG7A 1H03P 2XWJI 1QGBA 1OJVA 1QUBA 1GKNA 1HCCA 3M7PA 2XRBA 3OP8A 2XRDA 2MCYA 4DJZA 3KXVA 1GHQB 4JHSA 4B2SA 1MD8A 3T5OA 4LOTA 1G4FA 3NFPI 4WJG2 3R62A 4AYMA 1E8BA 2IZ3A 2B5ID 3L89M 2RKYA 3CALA 1PPQA 5HYTB 1QO6A 4K12A 5FO8C 5HZPB 2KRIA 3GXEA 4AYDA 2LOJA 3IU3I 1G4GA 2EHFA 4KKDA 3ZD2A 2YBYA 1HFHA 1ELVA 1E88A 4LOSA 4B2RA 2UWNA 3SW0X 1U5MA 1H2QP 4CSYA 1E5GA 4J38B 2YRAA 4YNXA 2XWBF 2RLQA 2O39C 2RL0A 2V8EA 4F4OC 3INBC 2MCZA
chains in the Genus database with same CATH superfamily
3MQLA 2WIIC 4C16A 3OEDC 4ZH1D 1OK1A 2EC3A 3FGRA 3ZLEA 1GPZA 1UOTP 3RJ3D 3ZD1A 3WSXA 1Z92B 1FBRA 3KZJA 1TPMA 2IZ4A 2A55A 3K3TA 3ERBA 3IX0A 4PO7A 5I0QB 1H04P 1SS2A 4PZ5A 2I2LA 2ERJA 2QY0A 4MUCA 4YIZA 5JPMG 4APLA 1ZJKA 2CG6A 1LY2A 3O8EB 2RKZA 3TVJA 4BWCA 1VVDA 4AYIA 3OXUD 3ZRZA 2G7IA 2CKUA 2KMSA 2JRAA 4ONTD 5HYUB 2JGXA 1SRZA 3FGTA 3EJHA 1C1ZA 1TPNA 1H2PP 1GKGA 1CKLA 1OK2A 2JGWA 3GOVA 2W81A 4A5WB 5HYPA 3ZLDA 5DN4A 1NWVA 1OJWA 1MD7A 1OK9A 2XQWC 4AYEA 4IGDA 1TPGA 1OJYA 1Q3XA 2BZMA 1O9AA 1VVCA 4FXGG 2RLPA 1HFIA 1OK3A 2W80A 2CG7A 1H03P 2XWJI 1QGBA 1OJVA 2Y8TA 1QUBA 1GKNA 2ZYCA 1HCCA 3M7PA 2XRBA 3OP8A 2XRDA 2MCYA 4DJZA 3KXVA 1GHQB 4JHSA 4B2SA 1MD8A 5DN5A 3T5OA 4LOTA 1G4FA 3NFPI 4WJG2 3R62A 4AYMA 2Y8SA 3WSYA 1E8BA 2IZ3A 4N7EA 3NJAA 2B5ID 3L89M 2RKYA 3CALA 1PPQA 5HYTB 1QO6A 3F6KA 4K12A 3VWOA 3CI0J 5FO8C 5HZPB 2Y8RA 2KRIA 4MSLA 3GXEA 4AYDA 2LOJA 3IU3I 1G4GA 2EHFA 4KKDA 3ZD2A 2YBYA 1HFHA 2X2ZA 1ELVA 1E88A 4LOSA 4B2RA 2UWNA 3SW0X 1U5MA 1H2QP 4CSYA 1E5GA 4J38B 2YRAA 4YNXA 1RLHA 2XWBF 2RLQA 2O39C 2RL0A 2V8EA 4F4OC 3INBC 2MCZA
chains in the Genus database with same CATH topology
3MQLA 2WIIC 4C16A 3OEDC 4ZH1D 1OK1A 2EC3A 1GPZA 1UOTP 3RJ3D 3ZD1A 1Z92B 1FBRA 3KZJA 1TPMA 2IZ4A 2A55A 3ERBA 3IX0A 5I0QB 1H04P 1SS2A 4PZ5A 2ERJA 2QY0A 4MUCA 5JPMG 1ZJKA 2CG6A 1LY2A 3O8EB 2RKZA 3TVJA 1VVDA 4AYIA 3OXUD 3ZRZA 2G7IA 2CKUA 2KMSA 2JRAA 4ONTD 5HYUB 2JGXA 1SRZA 3EJHA 1C1ZA 1TPNA 1H2PP 1GKGA 1CKLA 1OK2A 2JGWA 3GOVA 2W81A 4A5WB 5HYPA 1NWVA 1OJWA 1MD7A 1OK9A 2XQWC 4AYEA 4IGDA 1TPGA 1OJYA 1Q3XA 2BZMA 1O9AA 1VVCA 4FXGG 2RLPA 1HFIA 1OK3A 2W80A 2CG7A 1H03P 2XWJI 1QGBA 1OJVA 1QUBA 1GKNA 1HCCA 3M7PA 2XRBA 3OP8A 2XRDA 2MCYA 4DJZA 3KXVA 1GHQB 4JHSA 4B2SA 1MD8A 3T5OA 4LOTA 1G4FA 3NFPI 4WJG2 3R62A 4AYMA 1E8BA 2IZ3A 2B5ID 3L89M 2RKYA 3CALA 1PPQA 5HYTB 1QO6A 4K12A 5FO8C 5HZPB 2KRIA 3GXEA 4AYDA 2LOJA 3IU3I 1G4GA 2EHFA 4KKDA 3ZD2A 2YBYA 1HFHA 1ELVA 1E88A 4LOSA 4B2RA 2UWNA 3SW0X 1U5MA 1H2QP 4CSYA 1E5GA 4J38B 2YRAA 4YNXA 2XWBF 2RLQA 2O39C 2RL0A 2V8EA 4F4OC 3INBC 2MCZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MQL A;  2WII C;  4C16 A;  3OED C;  4ZH1 D;  1OK1 A;  2EC3 A;  1GPZ A;  1UOT P;  3RJ3 D;  3ZD1 A;  1Z92 B;  1FBR A;  3KZJ A;  1TPM A;  2IZ4 A;  2A55 A;  3ERB A;  3IX0 A;  5I0Q B;  1H04 P;  1SS2 A;  4PZ5 A;  2ERJ A;  2QY0 A;  4MUC A;  5JPM G;  1ZJK A;  2CG6 A;  1LY2 A;  3O8E B;  2RKZ A;  3TVJ A;  1VVD A;  4AYI A;  3OXU D;  3ZRZ A;  2G7I A;  2CKU A;  2KMS A;  2JRA A;  4ONT D;  5HYU B;  2JGX A;  1SRZ A;  3EJH A;  1C1Z A;  1TPN A;  1H2P P;  1GKG A;  1CKL A;  1OK2 A;  2JGW A;  3GOV A;  2W81 A;  4A5W B;  5HYP A;  1NWV A;  1OJW A;  1MD7 A;  1OK9 A;  2XQW C;  4AYE A;  4IGD A;  1TPG A;  1OJY A;  1Q3X A;  2BZM A;  1O9A A;  1VVC A;  4FXG G;  2RLP A;  1HFI A;  1OK3 A;  2W80 A;  2CG7 A;  1H03 P;  2XWJ I;  1QGB A;  1OJV A;  1QUB A;  1GKN A;  1HCC A;  3M7P A;  2XRB A;  3OP8 A;  2XRD A;  2MCY A;  4DJZ A;  3KXV A;  1GHQ B;  4JHS A;  4B2S A;  1MD8 A;  3T5O A;  4LOT A;  1G4F A;  3NFP I;  4WJG 2;  3R62 A;  4AYM A;  1E8B A;  2IZ3 A;  2B5I D;  3L89 M;  2RKY A;  3CAL A;  1PPQ A;  5HYT B;  1QO6 A;  4K12 A;  5FO8 C;  5HZP B;  2KRI A;  3GXE A;  4AYD A;  2LOJ A;  3IU3 I;  1G4G A;  2EHF A;  4KKD A;  3ZD2 A;  2YBY A;  1HFH A;  1ELV A;  1E88 A;  4LOS A;  4B2R A;  2UWN A;  3SW0 X;  1U5M A;  1H2Q P;  4CSY A;  1E5G A;  4J38 B;  2YRA A;  4YNX A;  2XWB F;  2RLQ A;  2O39 C;  2RL0 A;  2V8E A;  4F4O C;  3INB C;  2MCZ A; 
#chains in the Genus database with same CATH topology
 3MQL A;  2WII C;  4C16 A;  3OED C;  4ZH1 D;  1OK1 A;  2EC3 A;  3FGR A;  3ZLE A;  1GPZ A;  1UOT P;  3RJ3 D;  3ZD1 A;  3WSX A;  1Z92 B;  1FBR A;  3KZJ A;  1TPM A;  2IZ4 A;  2A55 A;  3K3T A;  3ERB A;  3IX0 A;  4PO7 A;  5I0Q B;  1H04 P;  1SS2 A;  4PZ5 A;  2I2L A;  2ERJ A;  2QY0 A;  4MUC A;  4YIZ A;  5JPM G;  4APL A;  1ZJK A;  2CG6 A;  1LY2 A;  3O8E B;  2RKZ A;  3TVJ A;  4BWC A;  1VVD A;  4AYI A;  3OXU D;  3ZRZ A;  2G7I A;  2CKU A;  2KMS A;  2JRA A;  4ONT D;  5HYU B;  2JGX A;  1SRZ A;  3FGT A;  3EJH A;  1C1Z A;  1TPN A;  1H2P P;  1GKG A;  1CKL A;  1OK2 A;  2JGW A;  3GOV A;  2W81 A;  4A5W B;  5HYP A;  3ZLD A;  5DN4 A;  1NWV A;  1OJW A;  1MD7 A;  1OK9 A;  2XQW C;  4AYE A;  4IGD A;  1TPG A;  1OJY A;  1Q3X A;  2BZM A;  1O9A A;  1VVC A;  4FXG G;  2RLP A;  1HFI A;  1OK3 A;  2W80 A;  2CG7 A;  1H03 P;  2XWJ I;  1QGB A;  1OJV A;  2Y8T A;  1QUB A;  1GKN A;  2ZYC A;  1HCC A;  3M7P A;  2XRB A;  3OP8 A;  2XRD A;  2MCY A;  4DJZ A;  3KXV A;  1GHQ B;  4JHS A;  4B2S A;  1MD8 A;  5DN5 A;  3T5O A;  4LOT A;  1G4F A;  3NFP I;  4WJG 2;  3R62 A;  4AYM A;  2Y8S A;  3WSY A;  1E8B A;  2IZ3 A;  4N7E A;  3NJA A;  2B5I D;  3L89 M;  2RKY A;  3CAL A;  1PPQ A;  5HYT B;  1QO6 A;  3F6K A;  4K12 A;  3VWO A;  3CI0 J;  5FO8 C;  5HZP B;  2Y8R A;  2KRI A;  4MSL A;  3GXE A;  4AYD A;  2LOJ A;  3IU3 I;  1G4G A;  2EHF A;  4KKD A;  3ZD2 A;  2YBY A;  1HFH A;  2X2Z A;  1ELV A;  1E88 A;  4LOS A;  4B2R A;  2UWN A;  3SW0 X;  1U5M A;  1H2Q P;  4CSY A;  1E5G A;  4J38 B;  2YRA A;  4YNX A;  1RLH A;  2XWB F;  2RLQ A;  2O39 C;  2RL0 A;  2V8E A;  4F4O C;  3INB C;  2MCZ A; 
#chains in the Genus database with same CATH homology
 3MQL A;  2WII C;  4C16 A;  3OED C;  4ZH1 D;  1OK1 A;  2EC3 A;  1GPZ A;  1UOT P;  3RJ3 D;  3ZD1 A;  1Z92 B;  1FBR A;  3KZJ A;  1TPM A;  2IZ4 A;  2A55 A;  3ERB A;  3IX0 A;  5I0Q B;  1H04 P;  1SS2 A;  4PZ5 A;  2ERJ A;  2QY0 A;  4MUC A;  5JPM G;  1ZJK A;  2CG6 A;  1LY2 A;  3O8E B;  2RKZ A;  3TVJ A;  1VVD A;  4AYI A;  3OXU D;  3ZRZ A;  2G7I A;  2CKU A;  2KMS A;  2JRA A;  4ONT D;  5HYU B;  2JGX A;  1SRZ A;  3EJH A;  1C1Z A;  1TPN A;  1H2P P;  1GKG A;  1CKL A;  1OK2 A;  2JGW A;  3GOV A;  2W81 A;  4A5W B;  5HYP A;  1NWV A;  1OJW A;  1MD7 A;  1OK9 A;  2XQW C;  4AYE A;  4IGD A;  1TPG A;  1OJY A;  1Q3X A;  2BZM A;  1O9A A;  1VVC A;  4FXG G;  2RLP A;  1HFI A;  1OK3 A;  2W80 A;  2CG7 A;  1H03 P;  2XWJ I;  1QGB A;  1OJV A;  1QUB A;  1GKN A;  1HCC A;  3M7P A;  2XRB A;  3OP8 A;  2XRD A;  2MCY A;  4DJZ A;  3KXV A;  1GHQ B;  4JHS A;  4B2S A;  1MD8 A;  3T5O A;  4LOT A;  1G4F A;  3NFP I;  4WJG 2;  3R62 A;  4AYM A;  1E8B A;  2IZ3 A;  2B5I D;  3L89 M;  2RKY A;  3CAL A;  1PPQ A;  5HYT B;  1QO6 A;  4K12 A;  5FO8 C;  5HZP B;  2KRI A;  3GXE A;  4AYD A;  2LOJ A;  3IU3 I;  1G4G A;  2EHF A;  4KKD A;  3ZD2 A;  2YBY A;  1HFH A;  1ELV A;  1E88 A;  4LOS A;  4B2R A;  2UWN A;  3SW0 X;  1U5M A;  1H2Q P;  4CSY A;  1E5G A;  4J38 B;  2YRA A;  4YNX A;  2XWB F;  2RLQ A;  2O39 C;  2RL0 A;  2V8E A;  4F4O C;  3INB C;  2MCZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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