4MSLA

Crystal structure of the vps10p domain of human sortilin/nts3 in complex with af40431
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
sequence length
663
structure length
654
Chain Sequence
CGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSMCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein
source organism Homo sapiens
publication title Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.
pubmed doi rcsb
molecule keywords Sortilin
total genus 154
structure length 654
sequence length 663
ec nomenclature
pdb deposition date 2013-09-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15901 Sortilin_C Sortilin, neurotensin receptor 3, C-terminal
A PF15902 Sortilin-Vps10 Sortilin, neurotensin receptor 3,
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.80 Mainly Beta Ribbon Complement Module; domain 1 Complement Module; domain 1 4mslA02
2.10.70.90 Mainly Beta Ribbon Complement Module; domain 1 Complement Module; domain 1 4mslA03
3F6KA 3WSXA 3WSYA 4N7EA 4MSLA 4PO7A
chains in the Genus database with same CATH superfamily
5JPMG 1HFIA 1OJVA 3GXEA 3IU3I 1VVDA 3CALA 1NWVA 1CKLA 3ERBA 3K3TA 1G4FA 3INBC 1RLHA 3CI0J 3EJHA 1Z92B 4PZ5A 3KZJA 1TPGA 2Y8RA 4J38B 5DN5A 4N7EA 4PO7A 1LY2A 1GKNA 2O39C 1OK3A 2YBYA 2MCYA 4K12A 3IX0A 1QO6A 4FXGG 3KXVA 4A5WB 3FGRA 1VVCA 1OJWA 3ZD2A 3ZD1A 2RL0A 4B2RA 4KKDA 1E5GA 4IGDA 2Y8SA 1UOTP 3ZLEA 4CSYA 2XRBA 4F4OC 4AYIA 4AYMA 2I2LA 5FO8C 4MUCA 4LOSA 1GKGA 3ZRZA 3FGTA 1U5MA 2ERJA 2XWJI 5HYUB 2QY0A 1GHQB 1QGBA 1HFHA 3F6KA 2B5ID 4B2SA 1ELVA 1ZJKA 2X2ZA 2UWNA 1H2PP 3MQLA 2XWBF 2V8EA 1Q3XA 2YRAA 4APLA 2ZYCA 1H04P 1OJYA 2KMSA 2G7IA 4LOTA 2CKUA 4BWCA 2CG7A 5HYPA 4C16A 1MD7A 3WSYA 2RLQA 1QUBA 2RKZA 3L89M 3OXUD 1OK2A 2MCZA 3SW0X 2WIIC 5I0QB 2XRDA 4WJG2 1H03P 4ZH1D 3GOVA 1TPNA 3OEDC 2RKYA 1E8BA 2W80A 1E88A 1SRZA 4AYEA 4DJZA 3ZLDA 2LOJA 3OP8A 2RLPA 2A55A 1OK9A 2CG6A 1C1ZA 3M7PA 1GPZA 3VWOA 2W81A 1HCCA 2EC3A 2JRAA 3R62A 3NFPI 2Y8TA 3T5OA 1FBRA 1MD8A 4ONTD 3O8EB 4JHSA 1SS2A 2IZ3A 4MSLA 3TVJA 2EHFA 5DN4A 2KRIA 2IZ4A 3WSXA 5HYTB 2JGWA 4AYDA 1G4GA 1TPMA 1H2QP 1OK1A 2BZMA 2XQWC 3RJ3D 4YNXA 1PPQA 3NJAA 5HZPB 4YIZA 2JGXA 1O9AA
chains in the Genus database with same CATH topology
2Y8TA 3ZLEA 3WSYA 2I2LA 3FGTA 4MSLA 2Y8RA 4PO7A 4N7EA 3F6KA 3WSXA 2X2ZA 3ZLDA 4APLA 3FGRA 3NJAA 4BWCA 4YIZA 2Y8SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F6K A;  3WSX A;  3WSY A;  4N7E A;  4MSL A;  4PO7 A; 
#chains in the Genus database with same CATH topology
 5JPM G;  1HFI A;  1OJV A;  3GXE A;  3IU3 I;  1VVD A;  3CAL A;  1NWV A;  1CKL A;  3ERB A;  3K3T A;  1G4F A;  3INB C;  1RLH A;  3CI0 J;  3EJH A;  1Z92 B;  4PZ5 A;  3KZJ A;  1TPG A;  2Y8R A;  4J38 B;  5DN5 A;  4N7E A;  4PO7 A;  1LY2 A;  1GKN A;  2O39 C;  1OK3 A;  2YBY A;  2MCY A;  4K12 A;  3IX0 A;  1QO6 A;  4FXG G;  3KXV A;  4A5W B;  3FGR A;  1VVC A;  1OJW A;  3ZD2 A;  3ZD1 A;  2RL0 A;  4B2R A;  4KKD A;  1E5G A;  4IGD A;  2Y8S A;  1UOT P;  3ZLE A;  4CSY A;  2XRB A;  4F4O C;  4AYI A;  4AYM A;  2I2L A;  5FO8 C;  4MUC A;  4LOS A;  1GKG A;  3ZRZ A;  3FGT A;  1U5M A;  2ERJ A;  2XWJ I;  5HYU B;  2QY0 A;  1GHQ B;  1QGB A;  1HFH A;  3F6K A;  2B5I D;  4B2S A;  1ELV A;  1ZJK A;  2X2Z A;  2UWN A;  1H2P P;  3MQL A;  2XWB F;  2V8E A;  1Q3X A;  2YRA A;  4APL A;  2ZYC A;  1H04 P;  1OJY A;  2KMS A;  2G7I A;  4LOT A;  2CKU A;  4BWC A;  2CG7 A;  5HYP A;  4C16 A;  1MD7 A;  3WSY A;  2RLQ A;  1QUB A;  2RKZ A;  3L89 M;  3OXU D;  1OK2 A;  2MCZ A;  3SW0 X;  2WII C;  5I0Q B;  2XRD A;  4WJG 2;  1H03 P;  4ZH1 D;  3GOV A;  1TPN A;  3OED C;  2RKY A;  1E8B A;  2W80 A;  1E88 A;  1SRZ A;  4AYE A;  4DJZ A;  3ZLD A;  2LOJ A;  3OP8 A;  2RLP A;  2A55 A;  1OK9 A;  2CG6 A;  1C1Z A;  3M7P A;  1GPZ A;  3VWO A;  2W81 A;  1HCC A;  2EC3 A;  2JRA A;  3R62 A;  3NFP I;  2Y8T A;  3T5O A;  1FBR A;  1MD8 A;  4ONT D;  3O8E B;  4JHS A;  1SS2 A;  2IZ3 A;  4MSL A;  3TVJ A;  2EHF A;  5DN4 A;  2KRI A;  2IZ4 A;  3WSX A;  5HYT B;  2JGW A;  4AYD A;  1G4G A;  1TPM A;  1H2Q P;  1OK1 A;  2BZM A;  2XQW C;  3RJ3 D;  4YNX A;  1PPQ A;  3NJA A;  5HZP B;  4YIZ A;  2JGX A;  1O9A A; 
#chains in the Genus database with same CATH homology
 2Y8T A;  3ZLE A;  3WSY A;  2I2L A;  3FGT A;  4MSL A;  2Y8R A;  4PO7 A;  4N7E A;  3F6K A;  3WSX A;  2X2Z A;  3ZLD A;  4APL A;  3FGR A;  3NJA A;  4BWC A;  4YIZ A;  2Y8S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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