4MUCA

The 4th and 5th c-terminal domains of factor h related protein 1
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
123
structure length
123
Chain Sequence
TGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune system
source organism Homo sapiens
publication title The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease.
pubmed doi rcsb
molecule keywords Complement factor H-related protein 1
total genus 21
structure length 123
sequence length 123
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-09-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4mucA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4mucA02
1GPZA 1ZJKA 2XRBA 5HYUB 3EJHA 1O9AA 1OJYA 1H2QP 1VVCA 4FXGG 2A55A 2EHFA 1H2PP 1HCCA 3OXUD 3TVJA 2QY0A 1OK9A 4A5WB 4DJZA 5HYPA 2JGXA 1U5MA 1OJVA 1Z92B 3IX0A 3RJ3D 3ZRZA 1MD8A 1SS2A 1G4FA 3O8EB 2RLQA 1H03P 4B2SA 2G7IA 1OK3A 4LOSA 4B2RA 3ZD2A 3OP8A 2XQWC 4CSYA 1OJWA 2XRDA 2EC3A 1E8BA 4IGDA 2YRAA 4AYDA 2WIIC 2JGWA 1QO6A 2XWJI 1GKNA 2CG7A 3IU3I 2CG6A 4JHSA 3NFPI 1C1ZA 3INBC 3ZD1A 4AYMA 2RLPA 2W81A 4F4OC 1OK1A 2V8EA 1UOTP 2MCYA 3CALA 3KXVA 5HYTB 3SW0X 2KMSA 1HFHA 2UWNA 4MUCA 1SRZA 1PPQA 1QGBA 1NWVA 2JRAA 4YNXA 1E88A 1HFIA 4ONTD 1G4GA 2RKZA 1ELVA 1LY2A 4J38B 2RKYA 2YBYA 1OK2A 1FBRA 3GXEA 4PZ5A 3T5OA 2MCZA 5JPMG 5FO8C 1H04P 4WJG2 1CKLA 3R62A 2W80A 1TPGA 3M7PA 2ERJA 2B5ID 2RL0A 3ERBA 2BZMA 2O39C 1TPMA 3GOVA 4C16A 5HZPB 1TPNA 2IZ3A 2IZ4A 4KKDA 1E5GA 1GHQB 3MQLA 4K12A 5I0QB 4LOTA 2CKUA 1MD7A 3OEDC 1QUBA 4ZH1D 3L89M 1VVDA 1GKGA 3KZJA 4AYEA 1Q3XA 2LOJA 2KRIA 4AYIA 2XWBF
chains in the Genus database with same CATH superfamily
1GPZA 1ZJKA 4APLA 2XRBA 5HYUB 3EJHA 1O9AA 1OJYA 1H2QP 1VVCA 4FXGG 2A55A 2EHFA 1H2PP 1HCCA 4N7EA 3OXUD 3TVJA 2QY0A 3CI0J 1OK9A 4A5WB 4DJZA 5HYPA 2JGXA 1U5MA 1OJVA 1Z92B 3IX0A 3RJ3D 3ZRZA 1MD8A 1SS2A 1G4FA 3O8EB 2Y8RA 2RLQA 1H03P 4B2SA 2G7IA 1OK3A 4LOSA 4B2RA 5DN4A 3ZD2A 3WSXA 3FGTA 3OP8A 2XQWC 4CSYA 1OJWA 2XRDA 2EC3A 1E8BA 4IGDA 2YRAA 4AYDA 2WIIC 2JGWA 1QO6A 2XWJI 3ZLDA 1GKNA 2CG7A 3IU3I 2CG6A 4JHSA 3F6KA 3NFPI 1C1ZA 3INBC 3ZD1A 4AYMA 2RLPA 3ZLEA 2W81A 4F4OC 5DN5A 1OK1A 2V8EA 1UOTP 2MCYA 3CALA 3KXVA 5HYTB 2X2ZA 3SW0X 2KMSA 1HFHA 2UWNA 4MUCA 1SRZA 1PPQA 1QGBA 1NWVA 2JRAA 4YNXA 1E88A 1HFIA 3WSYA 4BWCA 4ONTD 1G4GA 2RKZA 1ELVA 1LY2A 4J38B 2RKYA 2YBYA 1OK2A 4YIZA 1FBRA 3GXEA 4PZ5A 3T5OA 2MCZA 5JPMG 3K3TA 5FO8C 1H04P 4WJG2 1CKLA 3VWOA 3R62A 2W80A 2I2LA 1TPGA 3M7PA 2ERJA 2B5ID 2RL0A 3ERBA 2BZMA 2O39C 1TPMA 3GOVA 2ZYCA 3NJAA 4MSLA 1TPNA 4C16A 5HZPB 2IZ3A 2IZ4A 4KKDA 1E5GA 1GHQB 3MQLA 2Y8TA 4K12A 5I0QB 4LOTA 2CKUA 1MD7A 1RLHA 3OEDC 1QUBA 4ZH1D 3L89M 1VVDA 1GKGA 3FGRA 4PO7A 3KZJA 2Y8SA 4AYEA 1Q3XA 2LOJA 2KRIA 4AYIA 2XWBF
chains in the Genus database with same CATH topology
1GPZA 1ZJKA 2XRBA 5HYUB 3EJHA 1O9AA 1OJYA 1H2QP 1VVCA 4FXGG 2A55A 2EHFA 1H2PP 1HCCA 3OXUD 3TVJA 2QY0A 1OK9A 4A5WB 4DJZA 5HYPA 2JGXA 1U5MA 1OJVA 1Z92B 3IX0A 3RJ3D 3ZRZA 1MD8A 1SS2A 1G4FA 3O8EB 2RLQA 1H03P 4B2SA 2G7IA 1OK3A 4LOSA 4B2RA 3ZD2A 3OP8A 2XQWC 4CSYA 1OJWA 2XRDA 2EC3A 1E8BA 4IGDA 2YRAA 4AYDA 2WIIC 2JGWA 1QO6A 2XWJI 1GKNA 2CG7A 3IU3I 2CG6A 4JHSA 3NFPI 1C1ZA 3INBC 3ZD1A 4AYMA 2RLPA 2W81A 4F4OC 1OK1A 2V8EA 1UOTP 2MCYA 3CALA 3KXVA 5HYTB 3SW0X 2KMSA 1HFHA 2UWNA 4MUCA 1SRZA 1PPQA 1QGBA 1NWVA 2JRAA 4YNXA 1E88A 1HFIA 4ONTD 1G4GA 2RKZA 1ELVA 1LY2A 4J38B 2RKYA 2YBYA 1OK2A 1FBRA 3GXEA 4PZ5A 3T5OA 2MCZA 5JPMG 5FO8C 1H04P 4WJG2 1CKLA 3R62A 2W80A 1TPGA 3M7PA 2ERJA 2B5ID 2RL0A 3ERBA 2BZMA 2O39C 1TPMA 3GOVA 4C16A 5HZPB 1TPNA 2IZ3A 2IZ4A 4KKDA 1E5GA 1GHQB 3MQLA 4K12A 5I0QB 4LOTA 2CKUA 1MD7A 3OEDC 1QUBA 4ZH1D 3L89M 1VVDA 1GKGA 3KZJA 4AYEA 1Q3XA 2LOJA 2KRIA 4AYIA 2XWBF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GPZ A;  1ZJK A;  2XRB A;  5HYU B;  3EJH A;  1O9A A;  1OJY A;  1H2Q P;  1VVC A;  4FXG G;  2A55 A;  2EHF A;  1H2P P;  1HCC A;  3OXU D;  3TVJ A;  2QY0 A;  1OK9 A;  4A5W B;  4DJZ A;  5HYP A;  2JGX A;  1U5M A;  1OJV A;  1Z92 B;  3IX0 A;  3RJ3 D;  3ZRZ A;  1MD8 A;  1SS2 A;  1G4F A;  3O8E B;  2RLQ A;  1H03 P;  4B2S A;  2G7I A;  1OK3 A;  4LOS A;  4B2R A;  3ZD2 A;  3OP8 A;  2XQW C;  4CSY A;  1OJW A;  2XRD A;  2EC3 A;  1E8B A;  4IGD A;  2YRA A;  4AYD A;  2WII C;  2JGW A;  1QO6 A;  2XWJ I;  1GKN A;  2CG7 A;  3IU3 I;  2CG6 A;  4JHS A;  3NFP I;  1C1Z A;  3INB C;  3ZD1 A;  4AYM A;  2RLP A;  2W81 A;  4F4O C;  1OK1 A;  2V8E A;  1UOT P;  2MCY A;  3CAL A;  3KXV A;  5HYT B;  3SW0 X;  2KMS A;  1HFH A;  2UWN A;  4MUC A;  1SRZ A;  1PPQ A;  1QGB A;  1NWV A;  2JRA A;  4YNX A;  1E88 A;  1HFI A;  4ONT D;  1G4G A;  2RKZ A;  1ELV A;  1LY2 A;  4J38 B;  2RKY A;  2YBY A;  1OK2 A;  1FBR A;  3GXE A;  4PZ5 A;  3T5O A;  2MCZ A;  5JPM G;  5FO8 C;  1H04 P;  4WJG 2;  1CKL A;  3R62 A;  2W80 A;  1TPG A;  3M7P A;  2ERJ A;  2B5I D;  2RL0 A;  3ERB A;  2BZM A;  2O39 C;  1TPM A;  3GOV A;  4C16 A;  5HZP B;  1TPN A;  2IZ3 A;  2IZ4 A;  4KKD A;  1E5G A;  1GHQ B;  3MQL A;  4K12 A;  5I0Q B;  4LOT A;  2CKU A;  1MD7 A;  3OED C;  1QUB A;  4ZH1 D;  3L89 M;  1VVD A;  1GKG A;  3KZJ A;  4AYE A;  1Q3X A;  2LOJ A;  2KRI A;  4AYI A;  2XWB F; 
#chains in the Genus database with same CATH topology
 1GPZ A;  1ZJK A;  4APL A;  2XRB A;  5HYU B;  3EJH A;  1O9A A;  1OJY A;  1H2Q P;  1VVC A;  4FXG G;  2A55 A;  2EHF A;  1H2P P;  1HCC A;  4N7E A;  3OXU D;  3TVJ A;  2QY0 A;  3CI0 J;  1OK9 A;  4A5W B;  4DJZ A;  5HYP A;  2JGX A;  1U5M A;  1OJV A;  1Z92 B;  3IX0 A;  3RJ3 D;  3ZRZ A;  1MD8 A;  1SS2 A;  1G4F A;  3O8E B;  2Y8R A;  2RLQ A;  1H03 P;  4B2S A;  2G7I A;  1OK3 A;  4LOS A;  4B2R A;  5DN4 A;  3ZD2 A;  3WSX A;  3FGT A;  3OP8 A;  2XQW C;  4CSY A;  1OJW A;  2XRD A;  2EC3 A;  1E8B A;  4IGD A;  2YRA A;  4AYD A;  2WII C;  2JGW A;  1QO6 A;  2XWJ I;  3ZLD A;  1GKN A;  2CG7 A;  3IU3 I;  2CG6 A;  4JHS A;  3F6K A;  3NFP I;  1C1Z A;  3INB C;  3ZD1 A;  4AYM A;  2RLP A;  3ZLE A;  2W81 A;  4F4O C;  5DN5 A;  1OK1 A;  2V8E A;  1UOT P;  2MCY A;  3CAL A;  3KXV A;  5HYT B;  2X2Z A;  3SW0 X;  2KMS A;  1HFH A;  2UWN A;  4MUC A;  1SRZ A;  1PPQ A;  1QGB A;  1NWV A;  2JRA A;  4YNX A;  1E88 A;  1HFI A;  3WSY A;  4BWC A;  4ONT D;  1G4G A;  2RKZ A;  1ELV A;  1LY2 A;  4J38 B;  2RKY A;  2YBY A;  1OK2 A;  4YIZ A;  1FBR A;  3GXE A;  4PZ5 A;  3T5O A;  2MCZ A;  5JPM G;  3K3T A;  5FO8 C;  1H04 P;  4WJG 2;  1CKL A;  3VWO A;  3R62 A;  2W80 A;  2I2L A;  1TPG A;  3M7P A;  2ERJ A;  2B5I D;  2RL0 A;  3ERB A;  2BZM A;  2O39 C;  1TPM A;  3GOV A;  2ZYC A;  3NJA A;  4MSL A;  1TPN A;  4C16 A;  5HZP B;  2IZ3 A;  2IZ4 A;  4KKD A;  1E5G A;  1GHQ B;  3MQL A;  2Y8T A;  4K12 A;  5I0Q B;  4LOT A;  2CKU A;  1MD7 A;  1RLH A;  3OED C;  1QUB A;  4ZH1 D;  3L89 M;  1VVD A;  1GKG A;  3FGR A;  4PO7 A;  3KZJ A;  2Y8S A;  4AYE A;  1Q3X A;  2LOJ A;  2KRI A;  4AYI A;  2XWB F; 
#chains in the Genus database with same CATH homology
 1GPZ A;  1ZJK A;  2XRB A;  5HYU B;  3EJH A;  1O9A A;  1OJY A;  1H2Q P;  1VVC A;  4FXG G;  2A55 A;  2EHF A;  1H2P P;  1HCC A;  3OXU D;  3TVJ A;  2QY0 A;  1OK9 A;  4A5W B;  4DJZ A;  5HYP A;  2JGX A;  1U5M A;  1OJV A;  1Z92 B;  3IX0 A;  3RJ3 D;  3ZRZ A;  1MD8 A;  1SS2 A;  1G4F A;  3O8E B;  2RLQ A;  1H03 P;  4B2S A;  2G7I A;  1OK3 A;  4LOS A;  4B2R A;  3ZD2 A;  3OP8 A;  2XQW C;  4CSY A;  1OJW A;  2XRD A;  2EC3 A;  1E8B A;  4IGD A;  2YRA A;  4AYD A;  2WII C;  2JGW A;  1QO6 A;  2XWJ I;  1GKN A;  2CG7 A;  3IU3 I;  2CG6 A;  4JHS A;  3NFP I;  1C1Z A;  3INB C;  3ZD1 A;  4AYM A;  2RLP A;  2W81 A;  4F4O C;  1OK1 A;  2V8E A;  1UOT P;  2MCY A;  3CAL A;  3KXV A;  5HYT B;  3SW0 X;  2KMS A;  1HFH A;  2UWN A;  4MUC A;  1SRZ A;  1PPQ A;  1QGB A;  1NWV A;  2JRA A;  4YNX A;  1E88 A;  1HFI A;  4ONT D;  1G4G A;  2RKZ A;  1ELV A;  1LY2 A;  4J38 B;  2RKY A;  2YBY A;  1OK2 A;  1FBR A;  3GXE A;  4PZ5 A;  3T5O A;  2MCZ A;  5JPM G;  5FO8 C;  1H04 P;  4WJG 2;  1CKL A;  3R62 A;  2W80 A;  1TPG A;  3M7P A;  2ERJ A;  2B5I D;  2RL0 A;  3ERB A;  2BZM A;  2O39 C;  1TPM A;  3GOV A;  4C16 A;  5HZP B;  1TPN A;  2IZ3 A;  2IZ4 A;  4KKD A;  1E5G A;  1GHQ B;  3MQL A;  4K12 A;  5I0Q B;  4LOT A;  2CKU A;  1MD7 A;  3OED C;  1QUB A;  4ZH1 D;  3L89 M;  1VVD A;  1GKG A;  3KZJ A;  4AYE A;  1Q3X A;  2LOJ A;  2KRI A;  4AYI A;  2XWB F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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