The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
140
|
sequence length |
662
|
structure length |
653
|
Chain Sequence |
GRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSMCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.
pubmed doi rcsb |
| molecule tags |
Signaling protein
|
| source organism |
Homo sapiens
|
| molecule keywords |
Sortilin
|
| total genus |
140
|
| structure length |
653
|
| sequence length |
662
|
| ec nomenclature | |
| pdb deposition date | 2013-10-15 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF15901 | Sortilin_C | Sortilin, neurotensin receptor 3, C-terminal |
| A | PF15902 | Sortilin-Vps10 | Sortilin, neurotensin receptor 3, |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Ribbon | Complement Module; domain 1 | Complement Module; domain 1 | ||
| Mainly Beta | Ribbon | Complement Module; domain 1 | Complement Module; domain 1 |
#chains in the Genus database with same CATH superfamily 4PO7 A; 4MSL A; 3F6K A; 3WSY A; 4N7E A; 3WSX A; #chains in the Genus database with same CATH topology 4IGD A; 4WJG 2; 1C1Z A; 2KMS A; 2A55 A; 1PPQ A; 2Y8S A; 1TPG A; 1VVC A; 1TPM A; 2JGW A; 1FBR A; 1H04 P; 2I2L A; 1QO6 A; 3ZD1 A; 3L89 M; 2IZ3 A; 3ZLE A; 2W80 A; 5I0Q B; 3KZJ A; 4K12 A; 5DN5 A; 4AYM A; 4ZH1 D; 3TVJ A; 1OK3 A; 3NFP I; 2QY0 A; 2MCZ A; 1SRZ A; 2XRB A; 3FGT A; 4APL A; 1E5G A; 1TPN A; 1Z92 B; 4MSL A; 2XWJ I; 3ZLD A; 1MD7 A; 2UWN A; 1H03 P; 1U5M A; 1G4F A; 2YRA A; 1HCC A; 1NWV A; 2XWB F; 2RLP A; 5DN4 A; 4B2S A; 1OK2 A; 2CG6 A; 4KKD A; 3WSY A; 1OJW A; 2MCY A; 2XRD A; 4LOT A; 1E88 A; 2EC3 A; 3F6K A; 2B5I D; 2BZM A; 4JHS A; 4YNX A; 5JPM G; 2RLQ A; 1LY2 A; 3M7P A; 1OJV A; 2RKZ A; 4B2R A; 3ZRZ A; 1CKL A; 2IZ4 A; 5HZP B; 3VWO A; 3CI0 J; 1OK1 A; 2KRI A; 2Y8R A; 3ZD2 A; 3NJA A; 2YBY A; 4AYD A; 5HYU B; 1HFI A; 3EJH A; 3KXV A; 4DJZ A; 3OED C; 3RJ3 D; 2X2Z A; 2W81 A; 1GKG A; 3OP8 A; 1UOT P; 3ERB A; 4ONT D; 4PO7 A; 4AYE A; 1GHQ B; 3INB C; 3GXE A; 3K3T A; 5HYT B; 4CSY A; 4A5W B; 2JGX A; 2ZYC A; 3OXU D; 2JRA A; 1E8B A; 1GPZ A; 1OJY A; 4MUC A; 3IU3 I; 5FO8 C; 4FXG G; 5HYP A; 2WII C; 1OK9 A; 1ZJK A; 4F4O C; 1G4G A; 2G7I A; 2EHF A; 1MD8 A; 3R62 A; 3MQL A; 2CKU A; 3CAL A; 4PZ5 A; 3WSX A; 3O8E B; 3SW0 X; 1QUB A; 2CG7 A; 3IX0 A; 3T5O A; 1ELV A; 1H2Q P; 2ERJ A; 2Y8T A; 1RLH A; 1GKN A; 4N7E A; 2RKY A; 4AYI A; 3GOV A; 2RL0 A; 1HFH A; 1SS2 A; 4LOS A; 4C16 A; 4J38 B; 3FGR A; 1O9A A; 1Q3X A; 4BWC A; 2V8E A; 1H2P P; 1VVD A; 2LOJ A; 2XQW C; 4YIZ A; 2O39 C; 1QGB A; #chains in the Genus database with same CATH homology 2Y8T A; 4N7E A; 3WSY A; 2X2Z A; 2Y8S A; 4PO7 A; 3F6K A; 2I2L A; 3ZLE A; 3FGR A; 3FGT A; 4BWC A; 4APL A; 4MSL A; 2Y8R A; 4YIZ A; 3ZLD A; 3NJA A; 3WSX A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
