4N7EA

Crystal structure of the vps10p domain of human sortilin/nts3 in complex with af38469
Total Genus 140
100200300400500600020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
140
sequence length
662
structure length
653
Chain Sequence
GRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSMCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPE
100200300400500600600500400300200100
020406080100120140Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Signaling protein
source organism Homo sapiens
publication title The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.
pubmed doi rcsb
molecule keywords Sortilin
total genus 140
structure length 653
sequence length 662
ec nomenclature
pdb deposition date 2013-10-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15901 Sortilin_C Sortilin, neurotensin receptor 3, C-terminal
A PF15902 Sortilin-Vps10 Sortilin, neurotensin receptor 3,
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.80 Mainly Beta Ribbon Complement Module; domain 1 Complement Module; domain 1 4n7eA02
2.10.70.90 Mainly Beta Ribbon Complement Module; domain 1 Complement Module; domain 1 4n7eA03
4N7EA 3F6KA 4MSLA 3WSXA 4PO7A 3WSYA
chains in the Genus database with same CATH superfamily
5HYUB 2JGWA 2Y8SA 1SRZA 2QY0A 1H03P 2ERJA 1RLHA 2BZMA 2CKUA 3SW0X 1FBRA 3MQLA 2XQWC 4MSLA 2MCYA 2UWNA 3ZD2A 3L89M 3FGRA 1OJYA 3WSYA 4FXGG 2RLPA 4DJZA 1VVCA 5FO8C 3GXEA 3KZJA 4K12A 2XWBF 4C16A 3M7PA 1H2PP 3VWOA 1VVDA 4JHSA 1C1ZA 4BWCA 3OXUD 3F6KA 1GPZA 3ZLDA 1HFHA 3ZD1A 1G4FA 4N7EA 3T5OA 3ERBA 1OK1A 3RJ3D 3CI0J 3CALA 4ZH1D 1E88A 2LOJA 2WIIC 3OEDC 1H2QP 4MUCA 2RLQA 4IGDA 1MD7A 2Y8TA 4AYDA 2ZYCA 3IX0A 1NWVA 4B2RA 3OP8A 5DN4A 1GKGA 5JPMG 1OK3A 3ZRZA 4APLA 1OJWA 1E5GA 4J38B 2JRAA 2RL0A 2YRAA 5I0QB 2CG6A 1U5MA 4LOTA 1GHQB 2XRBA 1GKNA 3FGTA 2W80A 1Z92B 2JGXA 1ZJKA 2EC3A 2X2ZA 4PZ5A 2EHFA 3R62A 2KRIA 4F4OC 1E8BA 2XWJI 4WJG2 1OK9A 3EJHA 2A55A 2RKZA 5HYTB 3TVJA 1ELVA 2RKYA 3WSXA 2IZ3A 2V8EA 1CKLA 4PO7A 1O9AA 1LY2A 1PPQA 3ZLEA 5DN5A 3NJAA 2W81A 4LOSA 3INBC 1OK2A 1H04P 1SS2A 1TPGA 1UOTP 4KKDA 4AYMA 1HCCA 2B5ID 1QGBA 2IZ4A 3KXVA 1TPMA 2G7IA 1HFIA 1Q3XA 1QO6A 4YIZA 1OJVA 4AYIA 3GOVA 5HYPA 1TPNA 2O39C 3IU3I 1MD8A 1QUBA 2CG7A 5HZPB 3K3TA 3NFPI 4ONTD 3O8EB 1G4GA 2XRDA 2YBYA 2Y8RA 4A5WB 4B2SA 4CSYA 2I2LA 2KMSA 4AYEA 2MCZA 4YNXA
chains in the Genus database with same CATH topology
4BWCA 3F6KA 2Y8SA 3NJAA 4APLA 3ZLDA 4N7EA 4MSLA 3FGRA 3WSYA 3FGTA 4YIZA 2X2ZA 2Y8TA 3WSXA 2Y8RA 4PO7A 3ZLEA 2I2LA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4N7E A;  3F6K A;  4MSL A;  3WSX A;  4PO7 A;  3WSY A; 
#chains in the Genus database with same CATH topology
 5HYU B;  2JGW A;  2Y8S A;  1SRZ A;  2QY0 A;  1H03 P;  2ERJ A;  1RLH A;  2BZM A;  2CKU A;  3SW0 X;  1FBR A;  3MQL A;  2XQW C;  4MSL A;  2MCY A;  2UWN A;  3ZD2 A;  3L89 M;  3FGR A;  1OJY A;  3WSY A;  4FXG G;  2RLP A;  4DJZ A;  1VVC A;  5FO8 C;  3GXE A;  3KZJ A;  4K12 A;  2XWB F;  4C16 A;  3M7P A;  1H2P P;  3VWO A;  1VVD A;  4JHS A;  1C1Z A;  4BWC A;  3OXU D;  3F6K A;  1GPZ A;  3ZLD A;  1HFH A;  3ZD1 A;  1G4F A;  4N7E A;  3T5O A;  3ERB A;  1OK1 A;  3RJ3 D;  3CI0 J;  3CAL A;  4ZH1 D;  1E88 A;  2LOJ A;  2WII C;  3OED C;  1H2Q P;  4MUC A;  2RLQ A;  4IGD A;  1MD7 A;  2Y8T A;  4AYD A;  2ZYC A;  3IX0 A;  1NWV A;  4B2R A;  3OP8 A;  5DN4 A;  1GKG A;  5JPM G;  1OK3 A;  3ZRZ A;  4APL A;  1OJW A;  1E5G A;  4J38 B;  2JRA A;  2RL0 A;  2YRA A;  5I0Q B;  2CG6 A;  1U5M A;  4LOT A;  1GHQ B;  2XRB A;  1GKN A;  3FGT A;  2W80 A;  1Z92 B;  2JGX A;  1ZJK A;  2EC3 A;  2X2Z A;  4PZ5 A;  2EHF A;  3R62 A;  2KRI A;  4F4O C;  1E8B A;  2XWJ I;  4WJG 2;  1OK9 A;  3EJH A;  2A55 A;  2RKZ A;  5HYT B;  3TVJ A;  1ELV A;  2RKY A;  3WSX A;  2IZ3 A;  2V8E A;  1CKL A;  4PO7 A;  1O9A A;  1LY2 A;  1PPQ A;  3ZLE A;  5DN5 A;  3NJA A;  2W81 A;  4LOS A;  3INB C;  1OK2 A;  1H04 P;  1SS2 A;  1TPG A;  1UOT P;  4KKD A;  4AYM A;  1HCC A;  2B5I D;  1QGB A;  2IZ4 A;  3KXV A;  1TPM A;  2G7I A;  1HFI A;  1Q3X A;  1QO6 A;  4YIZ A;  1OJV A;  4AYI A;  3GOV A;  5HYP A;  1TPN A;  2O39 C;  3IU3 I;  1MD8 A;  1QUB A;  2CG7 A;  5HZP B;  3K3T A;  3NFP I;  4ONT D;  3O8E B;  1G4G A;  2XRD A;  2YBY A;  2Y8R A;  4A5W B;  4B2S A;  4CSY A;  2I2L A;  2KMS A;  4AYE A;  2MCZ A;  4YNX A; 
#chains in the Genus database with same CATH homology
 4BWC A;  3F6K A;  2Y8S A;  3NJA A;  4APL A;  3ZLD A;  4N7E A;  4MSL A;  3FGR A;  3WSY A;  3FGT A;  4YIZ A;  2X2Z A;  2Y8T A;  3WSX A;  2Y8R A;  4PO7 A;  3ZLE A;  2I2L A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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