4ZH1D

Complement factor h in complex with the gm1 glycan
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
126
structure length
126
Chain Sequence
FGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune system
source organism Homo sapiens
publication title Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.
pubmed doi rcsb
molecule keywords Complement C3
total genus 23
structure length 126
sequence length 126
chains with identical sequence E, F
ec nomenclature
pdb deposition date 2015-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4zh1D01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4zh1D02
4F4OC 1CKLA 4AYIA 2BZMA 3CALA 1G4FA 2XRDA 1H2PP 4AYMA 1GKGA 3TVJA 1Z92B 1GKNA 2MCZA 1TPMA 4ZH1D 2JRAA 1OJVA 4LOSA 5HYUB 3KZJA 1QGBA 2KRIA 4WJG2 5HZPB 3M7PA 2XWJI 5FO8C 3RJ3D 4JHSA 2CG6A 3OXUD 3INBC 4FXGG 5JPMG 3ZRZA 3NFPI 2UWNA 1H03P 2JGXA 4ONTD 4K12A 4DJZA 3ZD1A 2QY0A 4AYDA 1HFIA 1TPNA 3GOVA 3IU3I 3L89M 2IZ4A 1OK9A 3EJHA 2LOJA 2A55A 1E8BA 2YRAA 2IZ3A 2JGWA 2XRBA 3R62A 1HCCA 1MD7A 1OK3A 1ZJKA 1U5MA 1FBRA 3OP8A 4YNXA 4CSYA 2XQWC 5HYTB 1UOTP 3ERBA 2W80A 1H2QP 2YBYA 3O8EB 2B5ID 1SS2A 1QO6A 4IGDA 1OJYA 2KMSA 2WIIC 2RL0A 2CKUA 4AYEA 2RKYA 4B2RA 1TPGA 1O9AA 3SW0X 1VVCA 1E88A 1QUBA 1MD8A 2CG7A 4J38B 4C16A 1GHQB 2EC3A 4MUCA 5HYPA 3IX0A 2ERJA 1E5GA 1LY2A 4A5WB 1SRZA 2RKZA 1GPZA 1G4GA 4PZ5A 2G7IA 1PPQA 1NWVA 1H04P 2V8EA 4KKDA 1VVDA 1ELVA 3GXEA 2XWBF 2EHFA 1Q3XA 3ZD2A 2MCYA 5I0QB 2O39C 4B2SA 1HFHA 1OK2A 2RLQA 3KXVA 4LOTA 1OK1A 1OJWA 2W81A 2RLPA 3T5OA 3OEDC 1C1ZA 3MQLA
chains in the Genus database with same CATH superfamily
4F4OC 1CKLA 4AYIA 2BZMA 3CALA 1G4FA 2XRDA 1H2PP 4AYMA 1GKGA 3TVJA 1Z92B 1GKNA 2MCZA 4APLA 1TPMA 4ZH1D 2JRAA 1OJVA 3ZLDA 4LOSA 5HYUB 3FGRA 3CI0J 3KZJA 3WSXA 1QGBA 2KRIA 4WJG2 5HZPB 3M7PA 2XWJI 2X2ZA 5FO8C 3RJ3D 4JHSA 2CG6A 3ZLEA 3OXUD 3INBC 4FXGG 5JPMG 3ZRZA 3NFPI 2UWNA 1H03P 2JGXA 4ONTD 4MSLA 4K12A 4DJZA 3F6KA 3ZD1A 3WSYA 3VWOA 2QY0A 4AYDA 1HFIA 1TPNA 3GOVA 3IU3I 3L89M 2IZ4A 1OK9A 3EJHA 2LOJA 2A55A 4PO7A 1E8BA 2YRAA 4BWCA 2IZ3A 2JGWA 2XRBA 3R62A 1HCCA 1MD7A 1OK3A 1ZJKA 1U5MA 1FBRA 3OP8A 4YNXA 4CSYA 2XQWC 5HYTB 1UOTP 3ERBA 2W80A 1H2QP 2YBYA 3O8EB 2B5ID 1SS2A 1QO6A 4IGDA 1OJYA 2KMSA 2WIIC 2RL0A 2CKUA 4AYEA 2RKYA 3K3TA 5DN5A 4B2RA 1TPGA 1O9AA 3SW0X 1VVCA 1E88A 1QUBA 1MD8A 2CG7A 4N7EA 4J38B 4C16A 2Y8TA 2I2LA 3FGTA 1GHQB 2EC3A 2Y8RA 4MUCA 3NJAA 5HYPA 3IX0A 2ERJA 1E5GA 1LY2A 4A5WB 5DN4A 1SRZA 1RLHA 1GPZA 1G4GA 2RKZA 4PZ5A 2G7IA 1PPQA 1NWVA 1H04P 2V8EA 4KKDA 1VVDA 4YIZA 1ELVA 3GXEA 2XWBF 2EHFA 1Q3XA 3ZD2A 2MCYA 5I0QB 2O39C 4B2SA 1HFHA 1OK2A 2RLQA 3KXVA 4LOTA 1OK1A 1OJWA 2Y8SA 2W81A 2RLPA 2ZYCA 3T5OA 3OEDC 1C1ZA 3MQLA
chains in the Genus database with same CATH topology
4F4OC 1CKLA 4AYIA 2BZMA 3CALA 1G4FA 2XRDA 1H2PP 4AYMA 1GKGA 3TVJA 1Z92B 1GKNA 2MCZA 1TPMA 4ZH1D 2JRAA 1OJVA 4LOSA 5HYUB 3KZJA 1QGBA 2KRIA 4WJG2 5HZPB 3M7PA 2XWJI 5FO8C 3RJ3D 4JHSA 2CG6A 3OXUD 3INBC 4FXGG 5JPMG 3ZRZA 3NFPI 2UWNA 1H03P 2JGXA 4ONTD 4K12A 4DJZA 3ZD1A 2QY0A 4AYDA 1HFIA 1TPNA 3GOVA 3IU3I 3L89M 2IZ4A 1OK9A 3EJHA 2LOJA 2A55A 1E8BA 2YRAA 2IZ3A 2JGWA 2XRBA 3R62A 1HCCA 1MD7A 1OK3A 1ZJKA 1U5MA 1FBRA 3OP8A 4YNXA 4CSYA 2XQWC 5HYTB 1UOTP 3ERBA 2W80A 1H2QP 2YBYA 3O8EB 2B5ID 1SS2A 1QO6A 4IGDA 1OJYA 2KMSA 2WIIC 2RL0A 2CKUA 4AYEA 2RKYA 4B2RA 1TPGA 1O9AA 3SW0X 1VVCA 1E88A 1QUBA 1MD8A 2CG7A 4J38B 4C16A 1GHQB 2EC3A 4MUCA 5HYPA 3IX0A 2ERJA 1E5GA 1LY2A 4A5WB 1SRZA 2RKZA 1GPZA 1G4GA 4PZ5A 2G7IA 1PPQA 1NWVA 1H04P 2V8EA 4KKDA 1VVDA 1ELVA 3GXEA 2XWBF 2EHFA 1Q3XA 3ZD2A 2MCYA 5I0QB 2O39C 4B2SA 1HFHA 1OK2A 2RLQA 3KXVA 4LOTA 1OK1A 1OJWA 2W81A 2RLPA 3T5OA 3OEDC 1C1ZA 3MQLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F4O C;  1CKL A;  4AYI A;  2BZM A;  3CAL A;  1G4F A;  2XRD A;  1H2P P;  4AYM A;  1GKG A;  3TVJ A;  1Z92 B;  1GKN A;  2MCZ A;  1TPM A;  4ZH1 D;  2JRA A;  1OJV A;  4LOS A;  5HYU B;  3KZJ A;  1QGB A;  2KRI A;  4WJG 2;  5HZP B;  3M7P A;  2XWJ I;  5FO8 C;  3RJ3 D;  4JHS A;  2CG6 A;  3OXU D;  3INB C;  4FXG G;  5JPM G;  3ZRZ A;  3NFP I;  2UWN A;  1H03 P;  2JGX A;  4ONT D;  4K12 A;  4DJZ A;  3ZD1 A;  2QY0 A;  4AYD A;  1HFI A;  1TPN A;  3GOV A;  3IU3 I;  3L89 M;  2IZ4 A;  1OK9 A;  3EJH A;  2LOJ A;  2A55 A;  1E8B A;  2YRA A;  2IZ3 A;  2JGW A;  2XRB A;  3R62 A;  1HCC A;  1MD7 A;  1OK3 A;  1ZJK A;  1U5M A;  1FBR A;  3OP8 A;  4YNX A;  4CSY A;  2XQW C;  5HYT B;  1UOT P;  3ERB A;  2W80 A;  1H2Q P;  2YBY A;  3O8E B;  2B5I D;  1SS2 A;  1QO6 A;  4IGD A;  1OJY A;  2KMS A;  2WII C;  2RL0 A;  2CKU A;  4AYE A;  2RKY A;  4B2R A;  1TPG A;  1O9A A;  3SW0 X;  1VVC A;  1E88 A;  1QUB A;  1MD8 A;  2CG7 A;  4J38 B;  4C16 A;  1GHQ B;  2EC3 A;  4MUC A;  5HYP A;  3IX0 A;  2ERJ A;  1E5G A;  1LY2 A;  4A5W B;  1SRZ A;  2RKZ A;  1GPZ A;  1G4G A;  4PZ5 A;  2G7I A;  1PPQ A;  1NWV A;  1H04 P;  2V8E A;  4KKD A;  1VVD A;  1ELV A;  3GXE A;  2XWB F;  2EHF A;  1Q3X A;  3ZD2 A;  2MCY A;  5I0Q B;  2O39 C;  4B2S A;  1HFH A;  1OK2 A;  2RLQ A;  3KXV A;  4LOT A;  1OK1 A;  1OJW A;  2W81 A;  2RLP A;  3T5O A;  3OED C;  1C1Z A;  3MQL A; 
#chains in the Genus database with same CATH topology
 4F4O C;  1CKL A;  4AYI A;  2BZM A;  3CAL A;  1G4F A;  2XRD A;  1H2P P;  4AYM A;  1GKG A;  3TVJ A;  1Z92 B;  1GKN A;  2MCZ A;  4APL A;  1TPM A;  4ZH1 D;  2JRA A;  1OJV A;  3ZLD A;  4LOS A;  5HYU B;  3FGR A;  3CI0 J;  3KZJ A;  3WSX A;  1QGB A;  2KRI A;  4WJG 2;  5HZP B;  3M7P A;  2XWJ I;  2X2Z A;  5FO8 C;  3RJ3 D;  4JHS A;  2CG6 A;  3ZLE A;  3OXU D;  3INB C;  4FXG G;  5JPM G;  3ZRZ A;  3NFP I;  2UWN A;  1H03 P;  2JGX A;  4ONT D;  4MSL A;  4K12 A;  4DJZ A;  3F6K A;  3ZD1 A;  3WSY A;  3VWO A;  2QY0 A;  4AYD A;  1HFI A;  1TPN A;  3GOV A;  3IU3 I;  3L89 M;  2IZ4 A;  1OK9 A;  3EJH A;  2LOJ A;  2A55 A;  4PO7 A;  1E8B A;  2YRA A;  4BWC A;  2IZ3 A;  2JGW A;  2XRB A;  3R62 A;  1HCC A;  1MD7 A;  1OK3 A;  1ZJK A;  1U5M A;  1FBR A;  3OP8 A;  4YNX A;  4CSY A;  2XQW C;  5HYT B;  1UOT P;  3ERB A;  2W80 A;  1H2Q P;  2YBY A;  3O8E B;  2B5I D;  1SS2 A;  1QO6 A;  4IGD A;  1OJY A;  2KMS A;  2WII C;  2RL0 A;  2CKU A;  4AYE A;  2RKY A;  3K3T A;  5DN5 A;  4B2R A;  1TPG A;  1O9A A;  3SW0 X;  1VVC A;  1E88 A;  1QUB A;  1MD8 A;  2CG7 A;  4N7E A;  4J38 B;  4C16 A;  2Y8T A;  2I2L A;  3FGT A;  1GHQ B;  2EC3 A;  2Y8R A;  4MUC A;  3NJA A;  5HYP A;  3IX0 A;  2ERJ A;  1E5G A;  1LY2 A;  4A5W B;  5DN4 A;  1SRZ A;  1RLH A;  1GPZ A;  1G4G A;  2RKZ A;  4PZ5 A;  2G7I A;  1PPQ A;  1NWV A;  1H04 P;  2V8E A;  4KKD A;  1VVD A;  4YIZ A;  1ELV A;  3GXE A;  2XWB F;  2EHF A;  1Q3X A;  3ZD2 A;  2MCY A;  5I0Q B;  2O39 C;  4B2S A;  1HFH A;  1OK2 A;  2RLQ A;  3KXV A;  4LOT A;  1OK1 A;  1OJW A;  2Y8S A;  2W81 A;  2RLP A;  2ZYC A;  3T5O A;  3OED C;  1C1Z A;  3MQL A; 
#chains in the Genus database with same CATH homology
 4F4O C;  1CKL A;  4AYI A;  2BZM A;  3CAL A;  1G4F A;  2XRD A;  1H2P P;  4AYM A;  1GKG A;  3TVJ A;  1Z92 B;  1GKN A;  2MCZ A;  1TPM A;  4ZH1 D;  2JRA A;  1OJV A;  4LOS A;  5HYU B;  3KZJ A;  1QGB A;  2KRI A;  4WJG 2;  5HZP B;  3M7P A;  2XWJ I;  5FO8 C;  3RJ3 D;  4JHS A;  2CG6 A;  3OXU D;  3INB C;  4FXG G;  5JPM G;  3ZRZ A;  3NFP I;  2UWN A;  1H03 P;  2JGX A;  4ONT D;  4K12 A;  4DJZ A;  3ZD1 A;  2QY0 A;  4AYD A;  1HFI A;  1TPN A;  3GOV A;  3IU3 I;  3L89 M;  2IZ4 A;  1OK9 A;  3EJH A;  2LOJ A;  2A55 A;  1E8B A;  2YRA A;  2IZ3 A;  2JGW A;  2XRB A;  3R62 A;  1HCC A;  1MD7 A;  1OK3 A;  1ZJK A;  1U5M A;  1FBR A;  3OP8 A;  4YNX A;  4CSY A;  2XQW C;  5HYT B;  1UOT P;  3ERB A;  2W80 A;  1H2Q P;  2YBY A;  3O8E B;  2B5I D;  1SS2 A;  1QO6 A;  4IGD A;  1OJY A;  2KMS A;  2WII C;  2RL0 A;  2CKU A;  4AYE A;  2RKY A;  4B2R A;  1TPG A;  1O9A A;  3SW0 X;  1VVC A;  1E88 A;  1QUB A;  1MD8 A;  2CG7 A;  4J38 B;  4C16 A;  1GHQ B;  2EC3 A;  4MUC A;  5HYP A;  3IX0 A;  2ERJ A;  1E5G A;  1LY2 A;  4A5W B;  1SRZ A;  2RKZ A;  1GPZ A;  1G4G A;  4PZ5 A;  2G7I A;  1PPQ A;  1NWV A;  1H04 P;  2V8E A;  4KKD A;  1VVD A;  1ELV A;  3GXE A;  2XWB F;  2EHF A;  1Q3X A;  3ZD2 A;  2MCY A;  5I0Q B;  2O39 C;  4B2S A;  1HFH A;  1OK2 A;  2RLQ A;  3KXV A;  4LOT A;  1OK1 A;  1OJW A;  2W81 A;  2RLP A;  3T5O A;  3OED C;  1C1Z A;  3MQL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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