5HYPA

Structure of human c4b-binding protein alpha cain ccp domains 1 and 2 in complex with the hypervariable region of group a streptococcus m28 protein
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
125
structure length
125
Chain Sequence
SNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
source organism Homo sapiens
publication title Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
pubmed doi rcsb
molecule keywords C4b-binding protein alpha chain
total genus 16
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2016-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hypA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hypA01
2RLQA 1H03P 2ERJA 1TPNA 4J38B 4KKDA 3KZJA 1SRZA 2JRAA 1VVDA 3OXUD 1QO6A 1LY2A 2CKUA 2EC3A 2CG7A 3ERBA 3ZD2A 2UWNA 3M7PA 4YNXA 4C16A 2RKZA 4AYEA 1U5MA 1OJYA 1VVCA 2W81A 3OEDC 2KMSA 1OK2A 4B2SA 1HFHA 1GPZA 3TVJA 4MUCA 2RL0A 2JGXA 1E88A 4B2RA 3IU3I 3ZRZA 3R62A 1OK3A 1H04P 4AYIA 2RLPA 4CSYA 4AYDA 2KRIA 4LOSA 1NWVA 2EHFA 1C1ZA 2IZ3A 1G4FA 2BZMA 1PPQA 2YRAA 1FBRA 2WIIC 4K12A 1SS2A 1ELVA 1H2PP 4AYMA 3CALA 1OK1A 1TPGA 4ONTD 1G4GA 1O9AA 1Q3XA 3GOVA 1MD7A 4ZH1D 2MCZA 3ZD1A 1H2QP 1OJWA 2A55A 3RJ3D 1E5GA 2O39C 2V8EA 3O8EB 1ZJKA 1OJVA 1OK9A 1HFIA 2G7IA 2LOJA 2RKYA 1GHQB 3IX0A 3GXEA 5FO8C 5HZPB 1UOTP 1Z92B 5HYTB 2JGWA 2CG6A 2XRBA 1MD8A 1CKLA 5HYPA 1GKGA 3NFPI 2YBYA 2XRDA 2IZ4A 4FXGG 1E8BA 3KXVA 4PZ5A 5HYUB 3T5OA 3OP8A 1QUBA 5JPMG 4IGDA 2MCYA 2W80A 4DJZA 1GKNA 3EJHA 3INBC 3SW0X 4JHSA 4A5WB 2XWJI 2XQWC 4WJG2 5I0QB 1QGBA 2B5ID 3L89M 3MQLA 1TPMA 2XWBF 1HCCA 4F4OC 4LOTA 2QY0A
chains in the Genus database with same CATH superfamily
2RLQA 1H03P 2ERJA 2Y8SA 3VWOA 3CI0J 1TPNA 3FGTA 4J38B 4KKDA 3KZJA 2ZYCA 3FGRA 4MSLA 1SRZA 2JRAA 1VVDA 3OXUD 1QO6A 1LY2A 2CKUA 2EC3A 2CG7A 3ERBA 3ZD2A 2UWNA 3M7PA 4YNXA 4C16A 2RKZA 4APLA 4AYEA 1U5MA 1OJYA 1VVCA 2W81A 3OEDC 2KMSA 1OK2A 4B2SA 1HFHA 1GPZA 3TVJA 4MUCA 2RL0A 2JGXA 1E88A 4B2RA 3IU3I 3ZRZA 3R62A 4YIZA 1OK3A 1H04P 3K3TA 4AYIA 2RLPA 4N7EA 4CSYA 4AYDA 2KRIA 4LOSA 1NWVA 2EHFA 1C1ZA 3NJAA 3WSXA 2IZ3A 1G4FA 2BZMA 1PPQA 2YRAA 1FBRA 2WIIC 4K12A 1SS2A 1ELVA 1H2PP 4AYMA 3CALA 4BWCA 1OK1A 1TPGA 2Y8TA 4ONTD 1G4GA 1O9AA 1Q3XA 4PO7A 3ZLDA 3GOVA 1MD7A 4ZH1D 2MCZA 3ZD1A 1H2QP 1OJWA 2A55A 3RJ3D 1E5GA 2O39C 2V8EA 3O8EB 1ZJKA 1OJVA 1OK9A 1HFIA 2G7IA 2LOJA 2RKYA 1GHQB 3IX0A 3GXEA 3F6KA 5FO8C 5HZPB 1RLHA 1UOTP 1Z92B 2JGWA 2CG6A 2XRBA 5HYTB 2Y8RA 1MD8A 1CKLA 5HYPA 1GKGA 3NFPI 2YBYA 2XRDA 2IZ4A 4FXGG 1E8BA 3KXVA 4PZ5A 5DN4A 3T5OA 5HYUB 3OP8A 1QUBA 2I2LA 5JPMG 3WSYA 4IGDA 2MCYA 2W80A 4DJZA 1GKNA 3EJHA 3INBC 5DN5A 3SW0X 4JHSA 4A5WB 2XWJI 2XQWC 4WJG2 5I0QB 1QGBA 2B5ID 3L89M 3MQLA 2X2ZA 3ZLEA 1TPMA 2XWBF 1HCCA 4F4OC 4LOTA 2QY0A
chains in the Genus database with same CATH topology
2RLQA 1H03P 2ERJA 1TPNA 4J38B 4KKDA 3KZJA 1SRZA 2JRAA 1VVDA 3OXUD 1QO6A 1LY2A 2CKUA 2EC3A 2CG7A 3ERBA 3ZD2A 2UWNA 3M7PA 4YNXA 4C16A 2RKZA 4AYEA 1U5MA 1OJYA 1VVCA 2W81A 3OEDC 2KMSA 1OK2A 4B2SA 1HFHA 1GPZA 3TVJA 4MUCA 2RL0A 2JGXA 1E88A 4B2RA 3IU3I 3ZRZA 3R62A 1OK3A 1H04P 4AYIA 2RLPA 4CSYA 4AYDA 2KRIA 4LOSA 1NWVA 2EHFA 1C1ZA 2IZ3A 1G4FA 2BZMA 1PPQA 2YRAA 1FBRA 2WIIC 4K12A 1SS2A 1ELVA 1H2PP 4AYMA 3CALA 1OK1A 1TPGA 4ONTD 1G4GA 1O9AA 1Q3XA 3GOVA 1MD7A 4ZH1D 2MCZA 3ZD1A 1H2QP 1OJWA 2A55A 3RJ3D 1E5GA 2O39C 2V8EA 3O8EB 1ZJKA 1OJVA 1OK9A 1HFIA 2G7IA 2LOJA 2RKYA 1GHQB 3IX0A 3GXEA 5FO8C 5HZPB 1UOTP 1Z92B 5HYTB 2JGWA 2CG6A 2XRBA 1MD8A 1CKLA 5HYPA 1GKGA 3NFPI 2YBYA 2XRDA 2IZ4A 4FXGG 1E8BA 3KXVA 4PZ5A 5HYUB 3T5OA 3OP8A 1QUBA 5JPMG 4IGDA 2MCYA 2W80A 4DJZA 1GKNA 3EJHA 3INBC 3SW0X 4JHSA 4A5WB 2XWJI 2XQWC 4WJG2 5I0QB 1QGBA 2B5ID 3L89M 3MQLA 1TPMA 2XWBF 1HCCA 4F4OC 4LOTA 2QY0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RLQ A;  1H03 P;  2ERJ A;  1TPN A;  4J38 B;  4KKD A;  3KZJ A;  1SRZ A;  2JRA A;  1VVD A;  3OXU D;  1QO6 A;  1LY2 A;  2CKU A;  2EC3 A;  2CG7 A;  3ERB A;  3ZD2 A;  2UWN A;  3M7P A;  4YNX A;  4C16 A;  2RKZ A;  4AYE A;  1U5M A;  1OJY A;  1VVC A;  2W81 A;  3OED C;  2KMS A;  1OK2 A;  4B2S A;  1HFH A;  1GPZ A;  3TVJ A;  4MUC A;  2RL0 A;  2JGX A;  1E88 A;  4B2R A;  3IU3 I;  3ZRZ A;  3R62 A;  1OK3 A;  1H04 P;  4AYI A;  2RLP A;  4CSY A;  4AYD A;  2KRI A;  4LOS A;  1NWV A;  2EHF A;  1C1Z A;  2IZ3 A;  1G4F A;  2BZM A;  1PPQ A;  2YRA A;  1FBR A;  2WII C;  4K12 A;  1SS2 A;  1ELV A;  1H2P P;  4AYM A;  3CAL A;  1OK1 A;  1TPG A;  4ONT D;  1G4G A;  1O9A A;  1Q3X A;  3GOV A;  1MD7 A;  4ZH1 D;  2MCZ A;  3ZD1 A;  1H2Q P;  1OJW A;  2A55 A;  3RJ3 D;  1E5G A;  2O39 C;  2V8E A;  3O8E B;  1ZJK A;  1OJV A;  1OK9 A;  1HFI A;  2G7I A;  2LOJ A;  2RKY A;  1GHQ B;  3IX0 A;  3GXE A;  5FO8 C;  5HZP B;  1UOT P;  1Z92 B;  5HYT B;  2JGW A;  2CG6 A;  2XRB A;  1MD8 A;  1CKL A;  5HYP A;  1GKG A;  3NFP I;  2YBY A;  2XRD A;  2IZ4 A;  4FXG G;  1E8B A;  3KXV A;  4PZ5 A;  5HYU B;  3T5O A;  3OP8 A;  1QUB A;  5JPM G;  4IGD A;  2MCY A;  2W80 A;  4DJZ A;  1GKN A;  3EJH A;  3INB C;  3SW0 X;  4JHS A;  4A5W B;  2XWJ I;  2XQW C;  4WJG 2;  5I0Q B;  1QGB A;  2B5I D;  3L89 M;  3MQL A;  1TPM A;  2XWB F;  1HCC A;  4F4O C;  4LOT A;  2QY0 A; 
#chains in the Genus database with same CATH topology
 2RLQ A;  1H03 P;  2ERJ A;  2Y8S A;  3VWO A;  3CI0 J;  1TPN A;  3FGT A;  4J38 B;  4KKD A;  3KZJ A;  2ZYC A;  3FGR A;  4MSL A;  1SRZ A;  2JRA A;  1VVD A;  3OXU D;  1QO6 A;  1LY2 A;  2CKU A;  2EC3 A;  2CG7 A;  3ERB A;  3ZD2 A;  2UWN A;  3M7P A;  4YNX A;  4C16 A;  2RKZ A;  4APL A;  4AYE A;  1U5M A;  1OJY A;  1VVC A;  2W81 A;  3OED C;  2KMS A;  1OK2 A;  4B2S A;  1HFH A;  1GPZ A;  3TVJ A;  4MUC A;  2RL0 A;  2JGX A;  1E88 A;  4B2R A;  3IU3 I;  3ZRZ A;  3R62 A;  4YIZ A;  1OK3 A;  1H04 P;  3K3T A;  4AYI A;  2RLP A;  4N7E A;  4CSY A;  4AYD A;  2KRI A;  4LOS A;  1NWV A;  2EHF A;  1C1Z A;  3NJA A;  3WSX A;  2IZ3 A;  1G4F A;  2BZM A;  1PPQ A;  2YRA A;  1FBR A;  2WII C;  4K12 A;  1SS2 A;  1ELV A;  1H2P P;  4AYM A;  3CAL A;  4BWC A;  1OK1 A;  1TPG A;  2Y8T A;  4ONT D;  1G4G A;  1O9A A;  1Q3X A;  4PO7 A;  3ZLD A;  3GOV A;  1MD7 A;  4ZH1 D;  2MCZ A;  3ZD1 A;  1H2Q P;  1OJW A;  2A55 A;  3RJ3 D;  1E5G A;  2O39 C;  2V8E A;  3O8E B;  1ZJK A;  1OJV A;  1OK9 A;  1HFI A;  2G7I A;  2LOJ A;  2RKY A;  1GHQ B;  3IX0 A;  3GXE A;  3F6K A;  5FO8 C;  5HZP B;  1RLH A;  1UOT P;  1Z92 B;  2JGW A;  2CG6 A;  2XRB A;  5HYT B;  2Y8R A;  1MD8 A;  1CKL A;  5HYP A;  1GKG A;  3NFP I;  2YBY A;  2XRD A;  2IZ4 A;  4FXG G;  1E8B A;  3KXV A;  4PZ5 A;  5DN4 A;  3T5O A;  5HYU B;  3OP8 A;  1QUB A;  2I2L A;  5JPM G;  3WSY A;  4IGD A;  2MCY A;  2W80 A;  4DJZ A;  1GKN A;  3EJH A;  3INB C;  5DN5 A;  3SW0 X;  4JHS A;  4A5W B;  2XWJ I;  2XQW C;  4WJG 2;  5I0Q B;  1QGB A;  2B5I D;  3L89 M;  3MQL A;  2X2Z A;  3ZLE A;  1TPM A;  2XWB F;  1HCC A;  4F4O C;  4LOT A;  2QY0 A; 
#chains in the Genus database with same CATH homology
 2RLQ A;  1H03 P;  2ERJ A;  1TPN A;  4J38 B;  4KKD A;  3KZJ A;  1SRZ A;  2JRA A;  1VVD A;  3OXU D;  1QO6 A;  1LY2 A;  2CKU A;  2EC3 A;  2CG7 A;  3ERB A;  3ZD2 A;  2UWN A;  3M7P A;  4YNX A;  4C16 A;  2RKZ A;  4AYE A;  1U5M A;  1OJY A;  1VVC A;  2W81 A;  3OED C;  2KMS A;  1OK2 A;  4B2S A;  1HFH A;  1GPZ A;  3TVJ A;  4MUC A;  2RL0 A;  2JGX A;  1E88 A;  4B2R A;  3IU3 I;  3ZRZ A;  3R62 A;  1OK3 A;  1H04 P;  4AYI A;  2RLP A;  4CSY A;  4AYD A;  2KRI A;  4LOS A;  1NWV A;  2EHF A;  1C1Z A;  2IZ3 A;  1G4F A;  2BZM A;  1PPQ A;  2YRA A;  1FBR A;  2WII C;  4K12 A;  1SS2 A;  1ELV A;  1H2P P;  4AYM A;  3CAL A;  1OK1 A;  1TPG A;  4ONT D;  1G4G A;  1O9A A;  1Q3X A;  3GOV A;  1MD7 A;  4ZH1 D;  2MCZ A;  3ZD1 A;  1H2Q P;  1OJW A;  2A55 A;  3RJ3 D;  1E5G A;  2O39 C;  2V8E A;  3O8E B;  1ZJK A;  1OJV A;  1OK9 A;  1HFI A;  2G7I A;  2LOJ A;  2RKY A;  1GHQ B;  3IX0 A;  3GXE A;  5FO8 C;  5HZP B;  1UOT P;  1Z92 B;  5HYT B;  2JGW A;  2CG6 A;  2XRB A;  1MD8 A;  1CKL A;  5HYP A;  1GKG A;  3NFP I;  2YBY A;  2XRD A;  2IZ4 A;  4FXG G;  1E8B A;  3KXV A;  4PZ5 A;  5HYU B;  3T5O A;  3OP8 A;  1QUB A;  5JPM G;  4IGD A;  2MCY A;  2W80 A;  4DJZ A;  1GKN A;  3EJH A;  3INB C;  3SW0 X;  4JHS A;  4A5W B;  2XWJ I;  2XQW C;  4WJG 2;  5I0Q B;  1QGB A;  2B5I D;  3L89 M;  3MQL A;  1TPM A;  2XWB F;  1HCC A;  4F4O C;  4LOT A;  2QY0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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