5HYPA

Structure of human c4b-binding protein alpha cain ccp domains 1 and 2 in complex with the hypervariable region of group a streptococcus m28 protein
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
125
structure length
125
Chain Sequence
SNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords C4b-binding protein alpha chain
total genus 16
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2016-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hypA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hypA01
5FO8C 3SW0X 1PPQA 4CSYA 1GKNA 1H2QP 1Z92B 4B2SA 1G4FA 2LOJA 3IX0A 2RKYA 2IZ3A 3O8EB 1O9AA 2XQWC 1C1ZA 1E88A 3M7PA 1U5MA 2RKZA 3ZRZA 3INBC 1OK2A 2XRBA 1SS2A 1ELVA 3TVJA 4MUCA 1E8BA 1H04P 4C16A 4A5WB 2WIIC 5I0QB 1HCCA 1QUBA 4K12A 2W80A 1LY2A 2V8EA 3IU3I 2JGWA 3OXUD 1OJVA 3R62A 2BZMA 4ZH1D 4AYMA 1OJWA 4AYEA 2A55A 3RJ3D 1H03P 1G4GA 4PZ5A 3KZJA 3OEDC 2UWNA 4LOTA 4ONTD 5HYPA 5JPMG 2KRIA 4IGDA 1HFIA 4YNXA 1GHQB 2CKUA 1VVDA 4FXGG 1MD8A 2XRDA 3KXVA 1OK1A 1SRZA 3T5OA 2CG7A 1GKGA 2W81A 2IZ4A 1CKLA 2O39C 2EHFA 2EC3A 3OP8A 2ERJA 3ZD1A 1OK3A 4AYDA 3L89M 4B2RA 3GXEA 5HYUB 2MCZA 2YRAA 1H2PP 2JRAA 2RLPA 2G7IA 2XWJI 1HFHA 4F4OC 2CG6A 4AYIA 2B5ID 3CALA 3ZD2A 1TPMA 1TPGA 4JHSA 4LOSA 4WJG2 1VVCA 1OJYA 1NWVA 1TPNA 3GOVA 2RL0A 4DJZA 4J38B 1OK9A 5HZPB 1E5GA 2XWBF 2YBYA 4KKDA 1MD7A 1FBRA 2RLQA 3MQLA 1GPZA 3ERBA 1ZJKA 1QGBA 3NFPI 2QY0A 1UOTP 2MCYA 5HYTB 3EJHA 2KMSA 2JGXA 1Q3XA 1QO6A
chains in the Genus database with same CATH superfamily
5FO8C 3SW0X 1PPQA 4CSYA 3FGRA 1GKNA 1H2QP 1Z92B 4B2SA 1G4FA 2LOJA 3IX0A 2RKYA 2IZ3A 3O8EB 3WSYA 1O9AA 2XQWC 1C1ZA 1E88A 3K3TA 1U5MA 3M7PA 2RKZA 3ZRZA 3INBC 2Y8TA 3FGTA 1OK2A 2XRBA 1SS2A 1ELVA 4YIZA 3TVJA 4MUCA 1E8BA 1H04P 4C16A 2ZYCA 4A5WB 2WIIC 5I0QB 1HCCA 1QUBA 4MSLA 4K12A 2W80A 1LY2A 2V8EA 3IU3I 2JGWA 3OXUD 1OJVA 2X2ZA 3R62A 2BZMA 4ZH1D 4N7EA 4AYMA 5DN4A 1OJWA 4AYEA 2A55A 3RJ3D 1H03P 1G4GA 4PZ5A 3KZJA 3OEDC 2UWNA 4LOTA 4ONTD 5HYPA 5JPMG 2KRIA 4IGDA 1HFIA 4YNXA 1GHQB 2CKUA 1VVDA 4FXGG 1MD8A 2XRDA 3KXVA 1OK1A 1SRZA 3T5OA 2CG7A 1GKGA 2W81A 2IZ4A 1CKLA 2O39C 2EHFA 2EC3A 3OP8A 2ERJA 3ZD1A 1OK3A 4PO7A 3F6KA 2I2LA 4AYDA 3L89M 5DN5A 4B2RA 3GXEA 5HYUB 2MCZA 2YRAA 1H2PP 2JRAA 2RLPA 2G7IA 2XWJI 1HFHA 2Y8RA 4F4OC 2CG6A 3ZLEA 4AYIA 2B5ID 2Y8SA 3VWOA 3CALA 3ZD2A 1TPMA 1TPGA 4JHSA 4LOSA 4WJG2 1VVCA 1OJYA 1NWVA 4BWCA 1TPNA 3GOVA 2RL0A 3NJAA 4J38B 4DJZA 1OK9A 5HZPB 3CI0J 1E5GA 1RLHA 2XWBF 2YBYA 4KKDA 1MD7A 3ZLDA 1FBRA 2RLQA 3MQLA 1GPZA 3ERBA 1ZJKA 1QGBA 3WSXA 3NFPI 2QY0A 1UOTP 2MCYA 5HYTB 3EJHA 2KMSA 4APLA 2JGXA 1Q3XA 1QO6A
chains in the Genus database with same CATH topology
5FO8C 3SW0X 1PPQA 4CSYA 1GKNA 1H2QP 1Z92B 4B2SA 1G4FA 2LOJA 3IX0A 2RKYA 2IZ3A 3O8EB 1O9AA 2XQWC 1C1ZA 1E88A 3M7PA 1U5MA 2RKZA 3ZRZA 3INBC 1OK2A 2XRBA 1SS2A 1ELVA 3TVJA 4MUCA 1E8BA 1H04P 4C16A 4A5WB 2WIIC 5I0QB 1HCCA 1QUBA 4K12A 2W80A 1LY2A 2V8EA 3IU3I 2JGWA 3OXUD 1OJVA 3R62A 2BZMA 4ZH1D 4AYMA 1OJWA 4AYEA 2A55A 3RJ3D 1H03P 1G4GA 4PZ5A 3KZJA 3OEDC 2UWNA 4LOTA 4ONTD 5HYPA 5JPMG 2KRIA 4IGDA 1HFIA 4YNXA 1GHQB 2CKUA 1VVDA 4FXGG 1MD8A 2XRDA 3KXVA 1OK1A 1SRZA 3T5OA 2CG7A 1GKGA 2W81A 2IZ4A 1CKLA 2O39C 2EHFA 2EC3A 3OP8A 2ERJA 3ZD1A 1OK3A 4AYDA 3L89M 4B2RA 3GXEA 5HYUB 2MCZA 2YRAA 1H2PP 2JRAA 2RLPA 2G7IA 2XWJI 1HFHA 4F4OC 2CG6A 4AYIA 2B5ID 3CALA 3ZD2A 1TPMA 1TPGA 4JHSA 4LOSA 4WJG2 1VVCA 1OJYA 1NWVA 1TPNA 3GOVA 2RL0A 4DJZA 4J38B 1OK9A 5HZPB 1E5GA 2XWBF 2YBYA 4KKDA 1MD7A 1FBRA 2RLQA 3MQLA 1GPZA 3ERBA 1ZJKA 1QGBA 3NFPI 2QY0A 1UOTP 2MCYA 5HYTB 3EJHA 2KMSA 2JGXA 1Q3XA 1QO6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FO8 C;  3SW0 X;  1PPQ A;  4CSY A;  1GKN A;  1H2Q P;  1Z92 B;  4B2S A;  1G4F A;  2LOJ A;  3IX0 A;  2RKY A;  2IZ3 A;  3O8E B;  1O9A A;  2XQW C;  1C1Z A;  1E88 A;  3M7P A;  1U5M A;  2RKZ A;  3ZRZ A;  3INB C;  1OK2 A;  2XRB A;  1SS2 A;  1ELV A;  3TVJ A;  4MUC A;  1E8B A;  1H04 P;  4C16 A;  4A5W B;  2WII C;  5I0Q B;  1HCC A;  1QUB A;  4K12 A;  2W80 A;  1LY2 A;  2V8E A;  3IU3 I;  2JGW A;  3OXU D;  1OJV A;  3R62 A;  2BZM A;  4ZH1 D;  4AYM A;  1OJW A;  4AYE A;  2A55 A;  3RJ3 D;  1H03 P;  1G4G A;  4PZ5 A;  3KZJ A;  3OED C;  2UWN A;  4LOT A;  4ONT D;  5HYP A;  5JPM G;  2KRI A;  4IGD A;  1HFI A;  4YNX A;  1GHQ B;  2CKU A;  1VVD A;  4FXG G;  1MD8 A;  2XRD A;  3KXV A;  1OK1 A;  1SRZ A;  3T5O A;  2CG7 A;  1GKG A;  2W81 A;  2IZ4 A;  1CKL A;  2O39 C;  2EHF A;  2EC3 A;  3OP8 A;  2ERJ A;  3ZD1 A;  1OK3 A;  4AYD A;  3L89 M;  4B2R A;  3GXE A;  5HYU B;  2MCZ A;  2YRA A;  1H2P P;  2JRA A;  2RLP A;  2G7I A;  2XWJ I;  1HFH A;  4F4O C;  2CG6 A;  4AYI A;  2B5I D;  3CAL A;  3ZD2 A;  1TPM A;  1TPG A;  4JHS A;  4LOS A;  4WJG 2;  1VVC A;  1OJY A;  1NWV A;  1TPN A;  3GOV A;  2RL0 A;  4DJZ A;  4J38 B;  1OK9 A;  5HZP B;  1E5G A;  2XWB F;  2YBY A;  4KKD A;  1MD7 A;  1FBR A;  2RLQ A;  3MQL A;  1GPZ A;  3ERB A;  1ZJK A;  1QGB A;  3NFP I;  2QY0 A;  1UOT P;  2MCY A;  5HYT B;  3EJH A;  2KMS A;  2JGX A;  1Q3X A;  1QO6 A; 
#chains in the Genus database with same CATH topology
 5FO8 C;  3SW0 X;  1PPQ A;  4CSY A;  3FGR A;  1GKN A;  1H2Q P;  1Z92 B;  4B2S A;  1G4F A;  2LOJ A;  3IX0 A;  2RKY A;  2IZ3 A;  3O8E B;  3WSY A;  1O9A A;  2XQW C;  1C1Z A;  1E88 A;  3K3T A;  1U5M A;  3M7P A;  2RKZ A;  3ZRZ A;  3INB C;  2Y8T A;  3FGT A;  1OK2 A;  2XRB A;  1SS2 A;  1ELV A;  4YIZ A;  3TVJ A;  4MUC A;  1E8B A;  1H04 P;  4C16 A;  2ZYC A;  4A5W B;  2WII C;  5I0Q B;  1HCC A;  1QUB A;  4MSL A;  4K12 A;  2W80 A;  1LY2 A;  2V8E A;  3IU3 I;  2JGW A;  3OXU D;  1OJV A;  2X2Z A;  3R62 A;  2BZM A;  4ZH1 D;  4N7E A;  4AYM A;  5DN4 A;  1OJW A;  4AYE A;  2A55 A;  3RJ3 D;  1H03 P;  1G4G A;  4PZ5 A;  3KZJ A;  3OED C;  2UWN A;  4LOT A;  4ONT D;  5HYP A;  5JPM G;  2KRI A;  4IGD A;  1HFI A;  4YNX A;  1GHQ B;  2CKU A;  1VVD A;  4FXG G;  1MD8 A;  2XRD A;  3KXV A;  1OK1 A;  1SRZ A;  3T5O A;  2CG7 A;  1GKG A;  2W81 A;  2IZ4 A;  1CKL A;  2O39 C;  2EHF A;  2EC3 A;  3OP8 A;  2ERJ A;  3ZD1 A;  1OK3 A;  4PO7 A;  3F6K A;  2I2L A;  4AYD A;  3L89 M;  5DN5 A;  4B2R A;  3GXE A;  5HYU B;  2MCZ A;  2YRA A;  1H2P P;  2JRA A;  2RLP A;  2G7I A;  2XWJ I;  1HFH A;  2Y8R A;  4F4O C;  2CG6 A;  3ZLE A;  4AYI A;  2B5I D;  2Y8S A;  3VWO A;  3CAL A;  3ZD2 A;  1TPM A;  1TPG A;  4JHS A;  4LOS A;  4WJG 2;  1VVC A;  1OJY A;  1NWV A;  4BWC A;  1TPN A;  3GOV A;  2RL0 A;  3NJA A;  4J38 B;  4DJZ A;  1OK9 A;  5HZP B;  3CI0 J;  1E5G A;  1RLH A;  2XWB F;  2YBY A;  4KKD A;  1MD7 A;  3ZLD A;  1FBR A;  2RLQ A;  3MQL A;  1GPZ A;  3ERB A;  1ZJK A;  1QGB A;  3WSX A;  3NFP I;  2QY0 A;  1UOT P;  2MCY A;  5HYT B;  3EJH A;  2KMS A;  4APL A;  2JGX A;  1Q3X A;  1QO6 A; 
#chains in the Genus database with same CATH homology
 5FO8 C;  3SW0 X;  1PPQ A;  4CSY A;  1GKN A;  1H2Q P;  1Z92 B;  4B2S A;  1G4F A;  2LOJ A;  3IX0 A;  2RKY A;  2IZ3 A;  3O8E B;  1O9A A;  2XQW C;  1C1Z A;  1E88 A;  3M7P A;  1U5M A;  2RKZ A;  3ZRZ A;  3INB C;  1OK2 A;  2XRB A;  1SS2 A;  1ELV A;  3TVJ A;  4MUC A;  1E8B A;  1H04 P;  4C16 A;  4A5W B;  2WII C;  5I0Q B;  1HCC A;  1QUB A;  4K12 A;  2W80 A;  1LY2 A;  2V8E A;  3IU3 I;  2JGW A;  3OXU D;  1OJV A;  3R62 A;  2BZM A;  4ZH1 D;  4AYM A;  1OJW A;  4AYE A;  2A55 A;  3RJ3 D;  1H03 P;  1G4G A;  4PZ5 A;  3KZJ A;  3OED C;  2UWN A;  4LOT A;  4ONT D;  5HYP A;  5JPM G;  2KRI A;  4IGD A;  1HFI A;  4YNX A;  1GHQ B;  2CKU A;  1VVD A;  4FXG G;  1MD8 A;  2XRD A;  3KXV A;  1OK1 A;  1SRZ A;  3T5O A;  2CG7 A;  1GKG A;  2W81 A;  2IZ4 A;  1CKL A;  2O39 C;  2EHF A;  2EC3 A;  3OP8 A;  2ERJ A;  3ZD1 A;  1OK3 A;  4AYD A;  3L89 M;  4B2R A;  3GXE A;  5HYU B;  2MCZ A;  2YRA A;  1H2P P;  2JRA A;  2RLP A;  2G7I A;  2XWJ I;  1HFH A;  4F4O C;  2CG6 A;  4AYI A;  2B5I D;  3CAL A;  3ZD2 A;  1TPM A;  1TPG A;  4JHS A;  4LOS A;  4WJG 2;  1VVC A;  1OJY A;  1NWV A;  1TPN A;  3GOV A;  2RL0 A;  4DJZ A;  4J38 B;  1OK9 A;  5HZP B;  1E5G A;  2XWB F;  2YBY A;  4KKD A;  1MD7 A;  1FBR A;  2RLQ A;  3MQL A;  1GPZ A;  3ERB A;  1ZJK A;  1QGB A;  3NFP I;  2QY0 A;  1UOT P;  2MCY A;  5HYT B;  3EJH A;  2KMS A;  2JGX A;  1Q3X A;  1QO6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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