5HYUB

Structure of human c4b-binding protein alpha chain ccp domains 1 and 2 in complex with the hypervariable region of group a streptococcus m2 protein
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
125
structure length
125
Chain Sequence
SNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
pubmed doi rcsb
molecule tags Immune system
source organism Streptococcus pyogenes
molecule keywords M protein, serotype 2.1
total genus 21
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2016-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hyuB02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hyuB01
4B2SA 3TVJA 1OK1A 1C1ZA 3ZD2A 1HFIA 2RL0A 1OJWA 2EC3A 2ERJA 5HZPB 1HFHA 1OJYA 1MD7A 1ZJKA 1TPNA 1VVDA 2YRAA 1UOTP 4YNXA 1H2QP 2KMSA 1H03P 1OK3A 1SRZA 4AYDA 4LOTA 1G4FA 3KXVA 2G7IA 2CG6A 3OEDC 5FO8C 1GKNA 4JHSA 2RKYA 5I0QB 1VVCA 2EHFA 4K12A 4ZH1D 2KRIA 1GPZA 1ELVA 1U5MA 4C16A 2V8EA 2RKZA 3SW0X 2XRDA 5HYUB 3IX0A 4KKDA 1TPGA 3GOVA 4MUCA 3IU3I 4PZ5A 4AYIA 2XWBF 1CKLA 5HYTB 2JGXA 1H2PP 1E88A 4A5WB 3MQLA 2MCZA 2A55A 1OK9A 1O9AA 5JPMG 1GKGA 3T5OA 3GXEA 2MCYA 5HYPA 1OJVA 2JRAA 3ZD1A 3O8EB 1FBRA 2W81A 4CSYA 1SS2A 2RLQA 3KZJA 3M7PA 3EJHA 4F4OC 2BZMA 2B5ID 3OXUD 2YBYA 2RLPA 2XWJI 1TPMA 2JGWA 4LOSA 1OK2A 3RJ3D 1MD8A 4B2RA 2IZ3A 3NFPI 1G4GA 1QUBA 4J38B 3ERBA 3ZRZA 2LOJA 4IGDA 4WJG2 3L89M 1E8BA 1E5GA 1Q3XA 4ONTD 2WIIC 2XRBA 1LY2A 2CG7A 2CKUA 4AYMA 4AYEA 1HCCA 4FXGG 2XQWC 1NWVA 4DJZA 3OP8A 3CALA 2W80A 1QGBA 2UWNA 1QO6A 3R62A 1GHQB 2IZ4A 2QY0A 1Z92B 1PPQA 3INBC 1H04P 2O39C
chains in the Genus database with same CATH superfamily
4B2SA 3TVJA 1OK1A 1C1ZA 3CI0J 3ZD2A 1HFIA 2RL0A 1OJWA 2EC3A 3WSXA 2ERJA 2X2ZA 5HZPB 1HFHA 1OJYA 3F6KA 3FGRA 1MD7A 1ZJKA 1TPNA 1VVDA 2YRAA 1UOTP 4YNXA 1H2QP 2KMSA 1H03P 3FGTA 1OK3A 1SRZA 4AYDA 4LOTA 1G4FA 3KXVA 2G7IA 4BWCA 2CG6A 3OEDC 5FO8C 1GKNA 4JHSA 2RKYA 4APLA 5I0QB 1VVCA 3K3TA 2Y8SA 2EHFA 4K12A 4ZH1D 2KRIA 1GPZA 1ELVA 2Y8TA 1U5MA 4C16A 2V8EA 2RKZA 3SW0X 2XRDA 5HYUB 3ZLDA 3IX0A 4KKDA 1TPGA 3GOVA 4MUCA 3IU3I 4PZ5A 5DN4A 4AYIA 2XWBF 1CKLA 5HYTB 2JGXA 1H2PP 4N7EA 1E88A 4A5WB 3WSYA 3MQLA 2MCZA 2A55A 1OK9A 1O9AA 5JPMG 2ZYCA 1GKGA 3T5OA 3GXEA 2MCYA 5HYPA 1OJVA 2JRAA 3ZD1A 3O8EB 1FBRA 2W81A 4CSYA 1SS2A 2RLQA 5DN5A 3KZJA 3M7PA 3EJHA 4F4OC 2BZMA 2B5ID 3OXUD 2YBYA 2RLPA 1RLHA 2XWJI 1TPMA 2JGWA 4YIZA 4LOSA 1OK2A 3RJ3D 1MD8A 4B2RA 2IZ3A 3NFPI 1G4GA 1QUBA 3ZLEA 4J38B 3ERBA 3VWOA 3ZRZA 2LOJA 4IGDA 4WJG2 3L89M 1E8BA 1E5GA 1Q3XA 4ONTD 4MSLA 2WIIC 2XRBA 4PO7A 1LY2A 2I2LA 2CG7A 2CKUA 4AYMA 4AYEA 1HCCA 4FXGG 2XQWC 1NWVA 4DJZA 3OP8A 3CALA 2W80A 1QGBA 2UWNA 1QO6A 3R62A 1GHQB 2Y8RA 2IZ4A 2QY0A 1Z92B 3NJAA 1PPQA 3INBC 1H04P 2O39C
chains in the Genus database with same CATH topology
4B2SA 3TVJA 1OK1A 1C1ZA 3ZD2A 1HFIA 2RL0A 1OJWA 2EC3A 2ERJA 5HZPB 1HFHA 1OJYA 1MD7A 1ZJKA 1TPNA 1VVDA 2YRAA 1UOTP 4YNXA 1H2QP 2KMSA 1H03P 1OK3A 1SRZA 4AYDA 4LOTA 1G4FA 3KXVA 2G7IA 2CG6A 3OEDC 5FO8C 1GKNA 4JHSA 2RKYA 5I0QB 1VVCA 2EHFA 4K12A 4ZH1D 2KRIA 1GPZA 1ELVA 1U5MA 4C16A 2V8EA 2RKZA 3SW0X 2XRDA 5HYUB 3IX0A 4KKDA 1TPGA 3GOVA 4MUCA 3IU3I 4PZ5A 4AYIA 2XWBF 1CKLA 5HYTB 2JGXA 1H2PP 1E88A 4A5WB 3MQLA 2MCZA 2A55A 1OK9A 1O9AA 5JPMG 1GKGA 3T5OA 3GXEA 2MCYA 5HYPA 1OJVA 2JRAA 3ZD1A 3O8EB 1FBRA 2W81A 4CSYA 1SS2A 2RLQA 3KZJA 3M7PA 3EJHA 4F4OC 2BZMA 2B5ID 3OXUD 2YBYA 2RLPA 2XWJI 1TPMA 2JGWA 4LOSA 1OK2A 3RJ3D 1MD8A 4B2RA 2IZ3A 3NFPI 1G4GA 1QUBA 4J38B 3ERBA 3ZRZA 2LOJA 4IGDA 4WJG2 3L89M 1E8BA 1E5GA 1Q3XA 4ONTD 2WIIC 2XRBA 1LY2A 2CG7A 2CKUA 4AYMA 4AYEA 1HCCA 4FXGG 2XQWC 1NWVA 4DJZA 3OP8A 3CALA 2W80A 1QGBA 2UWNA 1QO6A 3R62A 1GHQB 2IZ4A 2QY0A 1Z92B 1PPQA 3INBC 1H04P 2O39C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4B2S A;  3TVJ A;  1OK1 A;  1C1Z A;  3ZD2 A;  1HFI A;  2RL0 A;  1OJW A;  2EC3 A;  2ERJ A;  5HZP B;  1HFH A;  1OJY A;  1MD7 A;  1ZJK A;  1TPN A;  1VVD A;  2YRA A;  1UOT P;  4YNX A;  1H2Q P;  2KMS A;  1H03 P;  1OK3 A;  1SRZ A;  4AYD A;  4LOT A;  1G4F A;  3KXV A;  2G7I A;  2CG6 A;  3OED C;  5FO8 C;  1GKN A;  4JHS A;  2RKY A;  5I0Q B;  1VVC A;  2EHF A;  4K12 A;  4ZH1 D;  2KRI A;  1GPZ A;  1ELV A;  1U5M A;  4C16 A;  2V8E A;  2RKZ A;  3SW0 X;  2XRD A;  5HYU B;  3IX0 A;  4KKD A;  1TPG A;  3GOV A;  4MUC A;  3IU3 I;  4PZ5 A;  4AYI A;  2XWB F;  1CKL A;  5HYT B;  2JGX A;  1H2P P;  1E88 A;  4A5W B;  3MQL A;  2MCZ A;  2A55 A;  1OK9 A;  1O9A A;  5JPM G;  1GKG A;  3T5O A;  3GXE A;  2MCY A;  5HYP A;  1OJV A;  2JRA A;  3ZD1 A;  3O8E B;  1FBR A;  2W81 A;  4CSY A;  1SS2 A;  2RLQ A;  3KZJ A;  3M7P A;  3EJH A;  4F4O C;  2BZM A;  2B5I D;  3OXU D;  2YBY A;  2RLP A;  2XWJ I;  1TPM A;  2JGW A;  4LOS A;  1OK2 A;  3RJ3 D;  1MD8 A;  4B2R A;  2IZ3 A;  3NFP I;  1G4G A;  1QUB A;  4J38 B;  3ERB A;  3ZRZ A;  2LOJ A;  4IGD A;  4WJG 2;  3L89 M;  1E8B A;  1E5G A;  1Q3X A;  4ONT D;  2WII C;  2XRB A;  1LY2 A;  2CG7 A;  2CKU A;  4AYM A;  4AYE A;  1HCC A;  4FXG G;  2XQW C;  1NWV A;  4DJZ A;  3OP8 A;  3CAL A;  2W80 A;  1QGB A;  2UWN A;  1QO6 A;  3R62 A;  1GHQ B;  2IZ4 A;  2QY0 A;  1Z92 B;  1PPQ A;  3INB C;  1H04 P;  2O39 C; 
#chains in the Genus database with same CATH topology
 4B2S A;  3TVJ A;  1OK1 A;  1C1Z A;  3CI0 J;  3ZD2 A;  1HFI A;  2RL0 A;  1OJW A;  2EC3 A;  3WSX A;  2ERJ A;  2X2Z A;  5HZP B;  1HFH A;  1OJY A;  3F6K A;  3FGR A;  1MD7 A;  1ZJK A;  1TPN A;  1VVD A;  2YRA A;  1UOT P;  4YNX A;  1H2Q P;  2KMS A;  1H03 P;  3FGT A;  1OK3 A;  1SRZ A;  4AYD A;  4LOT A;  1G4F A;  3KXV A;  2G7I A;  4BWC A;  2CG6 A;  3OED C;  5FO8 C;  1GKN A;  4JHS A;  2RKY A;  4APL A;  5I0Q B;  1VVC A;  3K3T A;  2Y8S A;  2EHF A;  4K12 A;  4ZH1 D;  2KRI A;  1GPZ A;  1ELV A;  2Y8T A;  1U5M A;  4C16 A;  2V8E A;  2RKZ A;  3SW0 X;  2XRD A;  5HYU B;  3ZLD A;  3IX0 A;  4KKD A;  1TPG A;  3GOV A;  4MUC A;  3IU3 I;  4PZ5 A;  5DN4 A;  4AYI A;  2XWB F;  1CKL A;  5HYT B;  2JGX A;  1H2P P;  4N7E A;  1E88 A;  4A5W B;  3WSY A;  3MQL A;  2MCZ A;  2A55 A;  1OK9 A;  1O9A A;  5JPM G;  2ZYC A;  1GKG A;  3T5O A;  3GXE A;  2MCY A;  5HYP A;  1OJV A;  2JRA A;  3ZD1 A;  3O8E B;  1FBR A;  2W81 A;  4CSY A;  1SS2 A;  2RLQ A;  5DN5 A;  3KZJ A;  3M7P A;  3EJH A;  4F4O C;  2BZM A;  2B5I D;  3OXU D;  2YBY A;  2RLP A;  1RLH A;  2XWJ I;  1TPM A;  2JGW A;  4YIZ A;  4LOS A;  1OK2 A;  3RJ3 D;  1MD8 A;  4B2R A;  2IZ3 A;  3NFP I;  1G4G A;  1QUB A;  3ZLE A;  4J38 B;  3ERB A;  3VWO A;  3ZRZ A;  2LOJ A;  4IGD A;  4WJG 2;  3L89 M;  1E8B A;  1E5G A;  1Q3X A;  4ONT D;  4MSL A;  2WII C;  2XRB A;  4PO7 A;  1LY2 A;  2I2L A;  2CG7 A;  2CKU A;  4AYM A;  4AYE A;  1HCC A;  4FXG G;  2XQW C;  1NWV A;  4DJZ A;  3OP8 A;  3CAL A;  2W80 A;  1QGB A;  2UWN A;  1QO6 A;  3R62 A;  1GHQ B;  2Y8R A;  2IZ4 A;  2QY0 A;  1Z92 B;  3NJA A;  1PPQ A;  3INB C;  1H04 P;  2O39 C; 
#chains in the Genus database with same CATH homology
 4B2S A;  3TVJ A;  1OK1 A;  1C1Z A;  3ZD2 A;  1HFI A;  2RL0 A;  1OJW A;  2EC3 A;  2ERJ A;  5HZP B;  1HFH A;  1OJY A;  1MD7 A;  1ZJK A;  1TPN A;  1VVD A;  2YRA A;  1UOT P;  4YNX A;  1H2Q P;  2KMS A;  1H03 P;  1OK3 A;  1SRZ A;  4AYD A;  4LOT A;  1G4F A;  3KXV A;  2G7I A;  2CG6 A;  3OED C;  5FO8 C;  1GKN A;  4JHS A;  2RKY A;  5I0Q B;  1VVC A;  2EHF A;  4K12 A;  4ZH1 D;  2KRI A;  1GPZ A;  1ELV A;  1U5M A;  4C16 A;  2V8E A;  2RKZ A;  3SW0 X;  2XRD A;  5HYU B;  3IX0 A;  4KKD A;  1TPG A;  3GOV A;  4MUC A;  3IU3 I;  4PZ5 A;  4AYI A;  2XWB F;  1CKL A;  5HYT B;  2JGX A;  1H2P P;  1E88 A;  4A5W B;  3MQL A;  2MCZ A;  2A55 A;  1OK9 A;  1O9A A;  5JPM G;  1GKG A;  3T5O A;  3GXE A;  2MCY A;  5HYP A;  1OJV A;  2JRA A;  3ZD1 A;  3O8E B;  1FBR A;  2W81 A;  4CSY A;  1SS2 A;  2RLQ A;  3KZJ A;  3M7P A;  3EJH A;  4F4O C;  2BZM A;  2B5I D;  3OXU D;  2YBY A;  2RLP A;  2XWJ I;  1TPM A;  2JGW A;  4LOS A;  1OK2 A;  3RJ3 D;  1MD8 A;  4B2R A;  2IZ3 A;  3NFP I;  1G4G A;  1QUB A;  4J38 B;  3ERB A;  3ZRZ A;  2LOJ A;  4IGD A;  4WJG 2;  3L89 M;  1E8B A;  1E5G A;  1Q3X A;  4ONT D;  2WII C;  2XRB A;  1LY2 A;  2CG7 A;  2CKU A;  4AYM A;  4AYE A;  1HCC A;  4FXG G;  2XQW C;  1NWV A;  4DJZ A;  3OP8 A;  3CAL A;  2W80 A;  1QGB A;  2UWN A;  1QO6 A;  3R62 A;  1GHQ B;  2IZ4 A;  2QY0 A;  1Z92 B;  1PPQ A;  3INB C;  1H04 P;  2O39 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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