5HYUB

Structure of human c4b-binding protein alpha chain ccp domains 1 and 2 in complex with the hypervariable region of group a streptococcus m2 protein
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
125
structure length
125
Chain Sequence
SNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
source organism Streptococcus pyogenes
publication title Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
pubmed doi rcsb
molecule keywords M protein, serotype 2.1
total genus 21
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2016-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hyuB02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hyuB01
4DJZA 3O8EB 1QO6A 1ZJKA 4WJG2 3SW0X 2BZMA 1OK2A 2XRDA 2G7IA 1ELVA 4IGDA 5HYPA 2JRAA 1MD7A 5HZPB 3ZD1A 2EC3A 4YNXA 4ONTD 3IU3I 1SRZA 5FO8C 1Z92B 3OEDC 2EHFA 1H2QP 1OK9A 2CG7A 2YRAA 3M7PA 3RJ3D 1Q3XA 2W80A 2O39C 3R62A 4PZ5A 3GXEA 1GKNA 2ERJA 3OXUD 1PPQA 1OJYA 4J38B 1OJWA 2KRIA 1CKLA 3EJHA 2XWJI 4JHSA 2RKYA 3NFPI 4KKDA 1VVCA 2JGWA 4C16A 1MD8A 1G4GA 4ZH1D 1TPGA 2MCZA 1GPZA 2W81A 3KZJA 3T5OA 2MCYA 1G4FA 3GOVA 2IZ3A 2RKZA 5HYUB 4A5WB 1QUBA 5I0QB 3CALA 1E5GA 1SS2A 1U5MA 2RL0A 4LOSA 3TVJA 2QY0A 3ZD2A 1GKGA 2KMSA 1HCCA 3L89M 1O9AA 2XQWC 2CG6A 2JGXA 1H04P 3OP8A 2RLPA 1OK1A 1OJVA 2IZ4A 1NWVA 4AYDA 1TPNA 2YBYA 4K12A 1E88A 4F4OC 1H03P 1VVDA 4AYIA 5JPMG 2LOJA 3ERBA 3KXVA 3INBC 2V8EA 2CKUA 4AYMA 1E8BA 4AYEA 1GHQB 1UOTP 4FXGG 1FBRA 1C1ZA 3ZRZA 2UWNA 1HFHA 2B5ID 4B2RA 2WIIC 4CSYA 5HYTB 2RLQA 4LOTA 4MUCA 2XRBA 1H2PP 1OK3A 2A55A 3MQLA 1TPMA 2XWBF 3IX0A 4B2SA 1LY2A 1QGBA 1HFIA
chains in the Genus database with same CATH superfamily
4YIZA 4DJZA 3O8EB 1QO6A 1ZJKA 4WJG2 3SW0X 2BZMA 1OK2A 2XRDA 2G7IA 1ELVA 4IGDA 5HYPA 2JRAA 3CI0J 1MD7A 5HZPB 3ZD1A 2EC3A 4YNXA 4ONTD 3IU3I 1SRZA 3VWOA 5FO8C 1Z92B 3OEDC 2EHFA 2Y8TA 1H2QP 1OK9A 2CG7A 2YRAA 3WSXA 2ZYCA 3M7PA 3RJ3D 1Q3XA 2W80A 2O39C 3R62A 4PZ5A 3GXEA 5DN4A 1GKNA 2ERJA 2Y8RA 3OXUD 1PPQA 1OJYA 4J38B 1OJWA 2KRIA 1CKLA 3EJHA 2XWJI 3FGTA 2RKYA 4JHSA 3NFPI 4KKDA 1VVCA 2JGWA 3FGRA 4APLA 4C16A 1MD8A 1G4GA 4ZH1D 1TPGA 2MCZA 1GPZA 2W81A 3KZJA 3T5OA 2MCYA 3ZLDA 1G4FA 3GOVA 2IZ3A 2RKZA 3K3TA 5HYUB 4A5WB 1QUBA 2Y8SA 5I0QB 3CALA 1E5GA 1SS2A 1U5MA 2RL0A 4LOSA 3ZLEA 3TVJA 2QY0A 3ZD2A 1GKGA 2KMSA 1HCCA 3L89M 1O9AA 2XQWC 2CG6A 3F6KA 2JGXA 1H04P 3OP8A 2RLPA 2X2ZA 1OK1A 4MSLA 1OJVA 2IZ4A 1NWVA 4AYDA 1TPNA 2YBYA 4K12A 1E88A 4F4OC 1H03P 2I2LA 1VVDA 4AYIA 5JPMG 4PO7A 2LOJA 3ERBA 3KXVA 3INBC 3WSYA 2V8EA 2CKUA 4AYMA 1E8BA 1RLHA 4AYEA 1GHQB 1UOTP 4FXGG 1FBRA 1C1ZA 3ZRZA 2UWNA 1HFHA 2B5ID 4B2RA 2WIIC 4CSYA 5DN5A 5HYTB 2RLQA 4LOTA 4MUCA 4N7EA 4BWCA 2XRBA 1H2PP 1OK3A 2A55A 3MQLA 1TPMA 2XWBF 3IX0A 4B2SA 3NJAA 1LY2A 1QGBA 1HFIA
chains in the Genus database with same CATH topology
4DJZA 3O8EB 1QO6A 1ZJKA 4WJG2 3SW0X 2BZMA 1OK2A 2XRDA 2G7IA 1ELVA 4IGDA 5HYPA 2JRAA 1MD7A 5HZPB 3ZD1A 2EC3A 4YNXA 4ONTD 3IU3I 1SRZA 5FO8C 1Z92B 3OEDC 2EHFA 1H2QP 1OK9A 2CG7A 2YRAA 3M7PA 3RJ3D 1Q3XA 2W80A 2O39C 3R62A 4PZ5A 3GXEA 1GKNA 2ERJA 3OXUD 1PPQA 1OJYA 4J38B 1OJWA 2KRIA 1CKLA 3EJHA 2XWJI 4JHSA 2RKYA 3NFPI 4KKDA 1VVCA 2JGWA 4C16A 1MD8A 1G4GA 4ZH1D 1TPGA 2MCZA 1GPZA 2W81A 3KZJA 3T5OA 2MCYA 1G4FA 3GOVA 2IZ3A 2RKZA 5HYUB 4A5WB 1QUBA 5I0QB 3CALA 1E5GA 1SS2A 1U5MA 2RL0A 4LOSA 3TVJA 2QY0A 3ZD2A 1GKGA 2KMSA 1HCCA 3L89M 1O9AA 2XQWC 2CG6A 2JGXA 1H04P 3OP8A 2RLPA 1OK1A 1OJVA 2IZ4A 1NWVA 4AYDA 1TPNA 2YBYA 4K12A 1E88A 4F4OC 1H03P 1VVDA 4AYIA 5JPMG 2LOJA 3ERBA 3KXVA 3INBC 2V8EA 2CKUA 4AYMA 1E8BA 4AYEA 1GHQB 1UOTP 4FXGG 1FBRA 1C1ZA 3ZRZA 2UWNA 1HFHA 2B5ID 4B2RA 2WIIC 4CSYA 5HYTB 2RLQA 4LOTA 4MUCA 2XRBA 1H2PP 1OK3A 2A55A 3MQLA 1TPMA 2XWBF 3IX0A 4B2SA 1LY2A 1QGBA 1HFIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DJZ A;  3O8E B;  1QO6 A;  1ZJK A;  4WJG 2;  3SW0 X;  2BZM A;  1OK2 A;  2XRD A;  2G7I A;  1ELV A;  4IGD A;  5HYP A;  2JRA A;  1MD7 A;  5HZP B;  3ZD1 A;  2EC3 A;  4YNX A;  4ONT D;  3IU3 I;  1SRZ A;  5FO8 C;  1Z92 B;  3OED C;  2EHF A;  1H2Q P;  1OK9 A;  2CG7 A;  2YRA A;  3M7P A;  3RJ3 D;  1Q3X A;  2W80 A;  2O39 C;  3R62 A;  4PZ5 A;  3GXE A;  1GKN A;  2ERJ A;  3OXU D;  1PPQ A;  1OJY A;  4J38 B;  1OJW A;  2KRI A;  1CKL A;  3EJH A;  2XWJ I;  4JHS A;  2RKY A;  3NFP I;  4KKD A;  1VVC A;  2JGW A;  4C16 A;  1MD8 A;  1G4G A;  4ZH1 D;  1TPG A;  2MCZ A;  1GPZ A;  2W81 A;  3KZJ A;  3T5O A;  2MCY A;  1G4F A;  3GOV A;  2IZ3 A;  2RKZ A;  5HYU B;  4A5W B;  1QUB A;  5I0Q B;  3CAL A;  1E5G A;  1SS2 A;  1U5M A;  2RL0 A;  4LOS A;  3TVJ A;  2QY0 A;  3ZD2 A;  1GKG A;  2KMS A;  1HCC A;  3L89 M;  1O9A A;  2XQW C;  2CG6 A;  2JGX A;  1H04 P;  3OP8 A;  2RLP A;  1OK1 A;  1OJV A;  2IZ4 A;  1NWV A;  4AYD A;  1TPN A;  2YBY A;  4K12 A;  1E88 A;  4F4O C;  1H03 P;  1VVD A;  4AYI A;  5JPM G;  2LOJ A;  3ERB A;  3KXV A;  3INB C;  2V8E A;  2CKU A;  4AYM A;  1E8B A;  4AYE A;  1GHQ B;  1UOT P;  4FXG G;  1FBR A;  1C1Z A;  3ZRZ A;  2UWN A;  1HFH A;  2B5I D;  4B2R A;  2WII C;  4CSY A;  5HYT B;  2RLQ A;  4LOT A;  4MUC A;  2XRB A;  1H2P P;  1OK3 A;  2A55 A;  3MQL A;  1TPM A;  2XWB F;  3IX0 A;  4B2S A;  1LY2 A;  1QGB A;  1HFI A; 
#chains in the Genus database with same CATH topology
 4YIZ A;  4DJZ A;  3O8E B;  1QO6 A;  1ZJK A;  4WJG 2;  3SW0 X;  2BZM A;  1OK2 A;  2XRD A;  2G7I A;  1ELV A;  4IGD A;  5HYP A;  2JRA A;  3CI0 J;  1MD7 A;  5HZP B;  3ZD1 A;  2EC3 A;  4YNX A;  4ONT D;  3IU3 I;  1SRZ A;  3VWO A;  5FO8 C;  1Z92 B;  3OED C;  2EHF A;  2Y8T A;  1H2Q P;  1OK9 A;  2CG7 A;  2YRA A;  3WSX A;  2ZYC A;  3M7P A;  3RJ3 D;  1Q3X A;  2W80 A;  2O39 C;  3R62 A;  4PZ5 A;  3GXE A;  5DN4 A;  1GKN A;  2ERJ A;  2Y8R A;  3OXU D;  1PPQ A;  1OJY A;  4J38 B;  1OJW A;  2KRI A;  1CKL A;  3EJH A;  2XWJ I;  3FGT A;  2RKY A;  4JHS A;  3NFP I;  4KKD A;  1VVC A;  2JGW A;  3FGR A;  4APL A;  4C16 A;  1MD8 A;  1G4G A;  4ZH1 D;  1TPG A;  2MCZ A;  1GPZ A;  2W81 A;  3KZJ A;  3T5O A;  2MCY A;  3ZLD A;  1G4F A;  3GOV A;  2IZ3 A;  2RKZ A;  3K3T A;  5HYU B;  4A5W B;  1QUB A;  2Y8S A;  5I0Q B;  3CAL A;  1E5G A;  1SS2 A;  1U5M A;  2RL0 A;  4LOS A;  3ZLE A;  3TVJ A;  2QY0 A;  3ZD2 A;  1GKG A;  2KMS A;  1HCC A;  3L89 M;  1O9A A;  2XQW C;  2CG6 A;  3F6K A;  2JGX A;  1H04 P;  3OP8 A;  2RLP A;  2X2Z A;  1OK1 A;  4MSL A;  1OJV A;  2IZ4 A;  1NWV A;  4AYD A;  1TPN A;  2YBY A;  4K12 A;  1E88 A;  4F4O C;  1H03 P;  2I2L A;  1VVD A;  4AYI A;  5JPM G;  4PO7 A;  2LOJ A;  3ERB A;  3KXV A;  3INB C;  3WSY A;  2V8E A;  2CKU A;  4AYM A;  1E8B A;  1RLH A;  4AYE A;  1GHQ B;  1UOT P;  4FXG G;  1FBR A;  1C1Z A;  3ZRZ A;  2UWN A;  1HFH A;  2B5I D;  4B2R A;  2WII C;  4CSY A;  5DN5 A;  5HYT B;  2RLQ A;  4LOT A;  4MUC A;  4N7E A;  4BWC A;  2XRB A;  1H2P P;  1OK3 A;  2A55 A;  3MQL A;  1TPM A;  2XWB F;  3IX0 A;  4B2S A;  3NJA A;  1LY2 A;  1QGB A;  1HFI A; 
#chains in the Genus database with same CATH homology
 4DJZ A;  3O8E B;  1QO6 A;  1ZJK A;  4WJG 2;  3SW0 X;  2BZM A;  1OK2 A;  2XRD A;  2G7I A;  1ELV A;  4IGD A;  5HYP A;  2JRA A;  1MD7 A;  5HZP B;  3ZD1 A;  2EC3 A;  4YNX A;  4ONT D;  3IU3 I;  1SRZ A;  5FO8 C;  1Z92 B;  3OED C;  2EHF A;  1H2Q P;  1OK9 A;  2CG7 A;  2YRA A;  3M7P A;  3RJ3 D;  1Q3X A;  2W80 A;  2O39 C;  3R62 A;  4PZ5 A;  3GXE A;  1GKN A;  2ERJ A;  3OXU D;  1PPQ A;  1OJY A;  4J38 B;  1OJW A;  2KRI A;  1CKL A;  3EJH A;  2XWJ I;  4JHS A;  2RKY A;  3NFP I;  4KKD A;  1VVC A;  2JGW A;  4C16 A;  1MD8 A;  1G4G A;  4ZH1 D;  1TPG A;  2MCZ A;  1GPZ A;  2W81 A;  3KZJ A;  3T5O A;  2MCY A;  1G4F A;  3GOV A;  2IZ3 A;  2RKZ A;  5HYU B;  4A5W B;  1QUB A;  5I0Q B;  3CAL A;  1E5G A;  1SS2 A;  1U5M A;  2RL0 A;  4LOS A;  3TVJ A;  2QY0 A;  3ZD2 A;  1GKG A;  2KMS A;  1HCC A;  3L89 M;  1O9A A;  2XQW C;  2CG6 A;  2JGX A;  1H04 P;  3OP8 A;  2RLP A;  1OK1 A;  1OJV A;  2IZ4 A;  1NWV A;  4AYD A;  1TPN A;  2YBY A;  4K12 A;  1E88 A;  4F4O C;  1H03 P;  1VVD A;  4AYI A;  5JPM G;  2LOJ A;  3ERB A;  3KXV A;  3INB C;  2V8E A;  2CKU A;  4AYM A;  1E8B A;  4AYE A;  1GHQ B;  1UOT P;  4FXG G;  1FBR A;  1C1Z A;  3ZRZ A;  2UWN A;  1HFH A;  2B5I D;  4B2R A;  2WII C;  4CSY A;  5HYT B;  2RLQ A;  4LOT A;  4MUC A;  2XRB A;  1H2P P;  1OK3 A;  2A55 A;  3MQL A;  1TPM A;  2XWB F;  3IX0 A;  4B2S A;  1LY2 A;  1QGB A;  1HFI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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