5HZPB

Structure of human c4b-binding protein alpha chain ccp domains 1 and 2 in complex with the hypervariable region of group a streptococcus m49 protein.
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
125
structure length
125
Chain Sequence
SNCGPPPTLSFAAPMDITLTETRFKTGTTMKYTCLPGYVRSHSTQTMTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
source organism Streptococcus pyogenes serotype m49
publication title Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
pubmed doi rcsb
molecule keywords M protein, serotype 49
total genus 18
structure length 125
sequence length 125
chains with identical sequence D
ec nomenclature
pdb deposition date 2016-02-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hzpB02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hzpB01
3MQLA 4MUCA 1TPMA 1U5MA 3KZJA 1H03P 3KXVA 2EHFA 2JRAA 3ZRZA 1Z92B 1E5GA 2O39C 4AYMA 2CG6A 2XWJI 3M7PA 4FXGG 2V8EA 1HCCA 2RLPA 2RKZA 3GXEA 4IGDA 4A5WB 1FBRA 1H04P 1GPZA 5HYUB 1G4GA 5FO8C 2XRBA 1OK2A 1GKNA 2XRDA 3INBC 1TPNA 4ONTD 1SS2A 3L89M 2RL0A 1OJWA 1VVDA 2QY0A 2W80A 1MD7A 2B5ID 3T5OA 3CALA 4PZ5A 1OJVA 5HYPA 2MCZA 4KKDA 5HYTB 2W81A 1E8BA 2JGWA 3GOVA 2WIIC 4K12A 4AYIA 1PPQA 1Q3XA 3ZD2A 1GKGA 2XWBF 2YRAA 2A55A 1SRZA 4LOTA 5JPMG 2RLQA 4DJZA 1E88A 1O9AA 1ELVA 2CKUA 3OP8A 1VVCA 4YNXA 1ZJKA 2MCYA 3OEDC 4B2SA 4AYDA 4CSYA 2IZ3A 3IU3I 2XQWC 3O8EB 1QGBA 2ERJA 2KRIA 3ERBA 2LOJA 1MD8A 3RJ3D 1GHQB 1LY2A 3NFPI 1OJYA 1UOTP 2KMSA 1HFHA 1QUBA 5HZPB 1OK3A 4JHSA 1NWVA 5I0QB 1C1ZA 3R62A 4B2RA 3TVJA 1QO6A 1H2QP 3SW0X 3IX0A 2YBYA 4AYEA 4J38B 1HFIA 4F4OC 1G4FA 1CKLA 2JGXA 4LOSA 1H2PP 1OK1A 2EC3A 2UWNA 3OXUD 1TPGA 4C16A 2RKYA 4ZH1D 2G7IA 4WJG2 1OK9A 3ZD1A 3EJHA 2BZMA 2CG7A 2IZ4A
chains in the Genus database with same CATH superfamily
3MQLA 4MUCA 1TPMA 1U5MA 3KZJA 1H03P 3KXVA 3WSXA 2EHFA 2JRAA 4APLA 3ZRZA 3ZLDA 1Z92B 1E5GA 2O39C 4AYMA 2CG6A 2XWJI 3M7PA 4YIZA 4FXGG 2V8EA 1HCCA 2RLPA 2RKZA 3GXEA 4IGDA 4A5WB 1RLHA 1FBRA 1H04P 1GPZA 5HYUB 1G4GA 5FO8C 2XRBA 1OK2A 1GKNA 2XRDA 3INBC 1TPNA 4ONTD 1SS2A 2Y8RA 3L89M 2RL0A 1OJWA 1VVDA 2QY0A 2W80A 1MD7A 2B5ID 5DN4A 3T5OA 3CALA 4PZ5A 1OJVA 5HYPA 2MCZA 4KKDA 5HYTB 2W81A 1E8BA 2JGWA 3GOVA 2WIIC 4K12A 4AYIA 1PPQA 1Q3XA 3ZD2A 1GKGA 3CI0J 2XWBF 2YRAA 2A55A 2Y8TA 1SRZA 4LOTA 5JPMG 2RLQA 4DJZA 1E88A 1O9AA 1ELVA 2CKUA 3OP8A 1VVCA 3FGTA 1ZJKA 2MCYA 4PO7A 4YNXA 3OEDC 4B2SA 4AYDA 4BWCA 4CSYA 2IZ3A 3IU3I 2XQWC 3O8EB 1QGBA 2ERJA 2KRIA 3ERBA 4N7EA 2LOJA 1MD8A 3RJ3D 1GHQB 1LY2A 3NFPI 1OJYA 1UOTP 2KMSA 1HFHA 1QUBA 3K3TA 2ZYCA 5HZPB 1OK3A 4JHSA 1NWVA 5I0QB 1C1ZA 2X2ZA 3F6KA 3R62A 4B2RA 3TVJA 1QO6A 1H2QP 3VWOA 3SW0X 3NJAA 3IX0A 2YBYA 4AYEA 5DN5A 4J38B 1HFIA 4F4OC 1G4FA 1CKLA 3ZLEA 2JGXA 4LOSA 1H2PP 3WSYA 1OK1A 2EC3A 2UWNA 3OXUD 1TPGA 4C16A 2RKYA 4ZH1D 2G7IA 4WJG2 1OK9A 3ZD1A 3EJHA 4MSLA 2BZMA 2CG7A 2Y8SA 2I2LA 3FGRA 2IZ4A
chains in the Genus database with same CATH topology
3MQLA 4MUCA 1TPMA 1U5MA 3KZJA 1H03P 3KXVA 2EHFA 2JRAA 3ZRZA 1Z92B 1E5GA 2O39C 4AYMA 2CG6A 2XWJI 3M7PA 4FXGG 2V8EA 1HCCA 2RLPA 2RKZA 3GXEA 4IGDA 4A5WB 1FBRA 1H04P 1GPZA 5HYUB 1G4GA 5FO8C 2XRBA 1OK2A 1GKNA 2XRDA 3INBC 1TPNA 4ONTD 1SS2A 3L89M 2RL0A 1OJWA 1VVDA 2QY0A 2W80A 1MD7A 2B5ID 3T5OA 3CALA 4PZ5A 1OJVA 5HYPA 2MCZA 4KKDA 5HYTB 2W81A 1E8BA 2JGWA 3GOVA 2WIIC 4K12A 4AYIA 1PPQA 1Q3XA 3ZD2A 1GKGA 2XWBF 2YRAA 2A55A 1SRZA 4LOTA 5JPMG 2RLQA 4DJZA 1E88A 1O9AA 1ELVA 2CKUA 3OP8A 1VVCA 4YNXA 1ZJKA 2MCYA 3OEDC 4B2SA 4AYDA 4CSYA 2IZ3A 3IU3I 2XQWC 3O8EB 1QGBA 2ERJA 2KRIA 3ERBA 2LOJA 1MD8A 3RJ3D 1GHQB 1LY2A 3NFPI 1OJYA 1UOTP 2KMSA 1HFHA 1QUBA 5HZPB 1OK3A 4JHSA 1NWVA 5I0QB 1C1ZA 3R62A 4B2RA 3TVJA 1QO6A 1H2QP 3SW0X 3IX0A 2YBYA 4AYEA 4J38B 1HFIA 4F4OC 1G4FA 1CKLA 2JGXA 4LOSA 1H2PP 1OK1A 2EC3A 2UWNA 3OXUD 1TPGA 4C16A 2RKYA 4ZH1D 2G7IA 4WJG2 1OK9A 3ZD1A 3EJHA 2BZMA 2CG7A 2IZ4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MQL A;  4MUC A;  1TPM A;  1U5M A;  3KZJ A;  1H03 P;  3KXV A;  2EHF A;  2JRA A;  3ZRZ A;  1Z92 B;  1E5G A;  2O39 C;  4AYM A;  2CG6 A;  2XWJ I;  3M7P A;  4FXG G;  2V8E A;  1HCC A;  2RLP A;  2RKZ A;  3GXE A;  4IGD A;  4A5W B;  1FBR A;  1H04 P;  1GPZ A;  5HYU B;  1G4G A;  5FO8 C;  2XRB A;  1OK2 A;  1GKN A;  2XRD A;  3INB C;  1TPN A;  4ONT D;  1SS2 A;  3L89 M;  2RL0 A;  1OJW A;  1VVD A;  2QY0 A;  2W80 A;  1MD7 A;  2B5I D;  3T5O A;  3CAL A;  4PZ5 A;  1OJV A;  5HYP A;  2MCZ A;  4KKD A;  5HYT B;  2W81 A;  1E8B A;  2JGW A;  3GOV A;  2WII C;  4K12 A;  4AYI A;  1PPQ A;  1Q3X A;  3ZD2 A;  1GKG A;  2XWB F;  2YRA A;  2A55 A;  1SRZ A;  4LOT A;  5JPM G;  2RLQ A;  4DJZ A;  1E88 A;  1O9A A;  1ELV A;  2CKU A;  3OP8 A;  1VVC A;  4YNX A;  1ZJK A;  2MCY A;  3OED C;  4B2S A;  4AYD A;  4CSY A;  2IZ3 A;  3IU3 I;  2XQW C;  3O8E B;  1QGB A;  2ERJ A;  2KRI A;  3ERB A;  2LOJ A;  1MD8 A;  3RJ3 D;  1GHQ B;  1LY2 A;  3NFP I;  1OJY A;  1UOT P;  2KMS A;  1HFH A;  1QUB A;  5HZP B;  1OK3 A;  4JHS A;  1NWV A;  5I0Q B;  1C1Z A;  3R62 A;  4B2R A;  3TVJ A;  1QO6 A;  1H2Q P;  3SW0 X;  3IX0 A;  2YBY A;  4AYE A;  4J38 B;  1HFI A;  4F4O C;  1G4F A;  1CKL A;  2JGX A;  4LOS A;  1H2P P;  1OK1 A;  2EC3 A;  2UWN A;  3OXU D;  1TPG A;  4C16 A;  2RKY A;  4ZH1 D;  2G7I A;  4WJG 2;  1OK9 A;  3ZD1 A;  3EJH A;  2BZM A;  2CG7 A;  2IZ4 A; 
#chains in the Genus database with same CATH topology
 3MQL A;  4MUC A;  1TPM A;  1U5M A;  3KZJ A;  1H03 P;  3KXV A;  3WSX A;  2EHF A;  2JRA A;  4APL A;  3ZRZ A;  3ZLD A;  1Z92 B;  1E5G A;  2O39 C;  4AYM A;  2CG6 A;  2XWJ I;  3M7P A;  4YIZ A;  4FXG G;  2V8E A;  1HCC A;  2RLP A;  2RKZ A;  3GXE A;  4IGD A;  4A5W B;  1RLH A;  1FBR A;  1H04 P;  1GPZ A;  5HYU B;  1G4G A;  5FO8 C;  2XRB A;  1OK2 A;  1GKN A;  2XRD A;  3INB C;  1TPN A;  4ONT D;  1SS2 A;  2Y8R A;  3L89 M;  2RL0 A;  1OJW A;  1VVD A;  2QY0 A;  2W80 A;  1MD7 A;  2B5I D;  5DN4 A;  3T5O A;  3CAL A;  4PZ5 A;  1OJV A;  5HYP A;  2MCZ A;  4KKD A;  5HYT B;  2W81 A;  1E8B A;  2JGW A;  3GOV A;  2WII C;  4K12 A;  4AYI A;  1PPQ A;  1Q3X A;  3ZD2 A;  1GKG A;  3CI0 J;  2XWB F;  2YRA A;  2A55 A;  2Y8T A;  1SRZ A;  4LOT A;  5JPM G;  2RLQ A;  4DJZ A;  1E88 A;  1O9A A;  1ELV A;  2CKU A;  3OP8 A;  1VVC A;  3FGT A;  1ZJK A;  2MCY A;  4PO7 A;  4YNX A;  3OED C;  4B2S A;  4AYD A;  4BWC A;  4CSY A;  2IZ3 A;  3IU3 I;  2XQW C;  3O8E B;  1QGB A;  2ERJ A;  2KRI A;  3ERB A;  4N7E A;  2LOJ A;  1MD8 A;  3RJ3 D;  1GHQ B;  1LY2 A;  3NFP I;  1OJY A;  1UOT P;  2KMS A;  1HFH A;  1QUB A;  3K3T A;  2ZYC A;  5HZP B;  1OK3 A;  4JHS A;  1NWV A;  5I0Q B;  1C1Z A;  2X2Z A;  3F6K A;  3R62 A;  4B2R A;  3TVJ A;  1QO6 A;  1H2Q P;  3VWO A;  3SW0 X;  3NJA A;  3IX0 A;  2YBY A;  4AYE A;  5DN5 A;  4J38 B;  1HFI A;  4F4O C;  1G4F A;  1CKL A;  3ZLE A;  2JGX A;  4LOS A;  1H2P P;  3WSY A;  1OK1 A;  2EC3 A;  2UWN A;  3OXU D;  1TPG A;  4C16 A;  2RKY A;  4ZH1 D;  2G7I A;  4WJG 2;  1OK9 A;  3ZD1 A;  3EJH A;  4MSL A;  2BZM A;  2CG7 A;  2Y8S A;  2I2L A;  3FGR A;  2IZ4 A; 
#chains in the Genus database with same CATH homology
 3MQL A;  4MUC A;  1TPM A;  1U5M A;  3KZJ A;  1H03 P;  3KXV A;  2EHF A;  2JRA A;  3ZRZ A;  1Z92 B;  1E5G A;  2O39 C;  4AYM A;  2CG6 A;  2XWJ I;  3M7P A;  4FXG G;  2V8E A;  1HCC A;  2RLP A;  2RKZ A;  3GXE A;  4IGD A;  4A5W B;  1FBR A;  1H04 P;  1GPZ A;  5HYU B;  1G4G A;  5FO8 C;  2XRB A;  1OK2 A;  1GKN A;  2XRD A;  3INB C;  1TPN A;  4ONT D;  1SS2 A;  3L89 M;  2RL0 A;  1OJW A;  1VVD A;  2QY0 A;  2W80 A;  1MD7 A;  2B5I D;  3T5O A;  3CAL A;  4PZ5 A;  1OJV A;  5HYP A;  2MCZ A;  4KKD A;  5HYT B;  2W81 A;  1E8B A;  2JGW A;  3GOV A;  2WII C;  4K12 A;  4AYI A;  1PPQ A;  1Q3X A;  3ZD2 A;  1GKG A;  2XWB F;  2YRA A;  2A55 A;  1SRZ A;  4LOT A;  5JPM G;  2RLQ A;  4DJZ A;  1E88 A;  1O9A A;  1ELV A;  2CKU A;  3OP8 A;  1VVC A;  4YNX A;  1ZJK A;  2MCY A;  3OED C;  4B2S A;  4AYD A;  4CSY A;  2IZ3 A;  3IU3 I;  2XQW C;  3O8E B;  1QGB A;  2ERJ A;  2KRI A;  3ERB A;  2LOJ A;  1MD8 A;  3RJ3 D;  1GHQ B;  1LY2 A;  3NFP I;  1OJY A;  1UOT P;  2KMS A;  1HFH A;  1QUB A;  5HZP B;  1OK3 A;  4JHS A;  1NWV A;  5I0Q B;  1C1Z A;  3R62 A;  4B2R A;  3TVJ A;  1QO6 A;  1H2Q P;  3SW0 X;  3IX0 A;  2YBY A;  4AYE A;  4J38 B;  1HFI A;  4F4O C;  1G4F A;  1CKL A;  2JGX A;  4LOS A;  1H2P P;  1OK1 A;  2EC3 A;  2UWN A;  3OXU D;  1TPG A;  4C16 A;  2RKY A;  4ZH1 D;  2G7I A;  4WJG 2;  1OK9 A;  3ZD1 A;  3EJH A;  2BZM A;  2CG7 A;  2IZ4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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