5I0QB

Structure of human c4b-binding protein alpha chain ccp domains 1 and 2 in complex with the hypervariable region of mutant group a streptococcus m2 (k65a, n66a) protein
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
125
structure length
125
Chain Sequence
SNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
pubmed doi rcsb
molecule tags Immune system
source organism Streptococcus pyogenes
molecule keywords M protein, serotype 2.1
total genus 22
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2016-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5i0qB02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5i0qB01
2JGXA 1H04P 3GXEA 4AYDA 1C1ZA 1VVDA 4ZH1D 3OXUD 2W81A 4LOSA 2YBYA 2CKUA 2BZMA 1G4GA 2MCYA 3IU3I 3M7PA 4PZ5A 2XQWC 1U5MA 2UWNA 3OP8A 1NWVA 1E88A 2JRAA 4J38B 2O39C 1GKNA 1ZJKA 4MUCA 1OK9A 3RJ3D 1TPNA 3TVJA 1H2QP 1OK1A 2XRBA 1OK3A 1CKLA 5HZPB 3INBC 4FXGG 1QGBA 4C16A 1E5GA 3IX0A 5JPMG 1HFIA 2A55A 3MQLA 2JGWA 3GOVA 2W80A 1GHQB 4AYEA 1TPMA 2KRIA 1HCCA 1OJWA 4AYMA 1HFHA 1MD8A 3OEDC 3ERBA 2CG7A 3ZD2A 1TPGA 2RKYA 3ZRZA 1VVCA 1FBRA 2RLPA 4JHSA 1O9AA 1G4FA 2XRDA 2EHFA 1OK2A 4IGDA 4K12A 4B2SA 2YRAA 4ONTD 2V8EA 5I0QB 3O8EB 3SW0X 1UOTP 2IZ4A 2WIIC 4F4OC 4AYIA 1Z92B 5HYUB 1QO6A 5FO8C 1QUBA 4LOTA 1PPQA 2RKZA 3CALA 2RLQA 5HYPA 2B5ID 1H03P 1ELVA 2XWBF 1E8BA 2RL0A 3R62A 4KKDA 3KXVA 2LOJA 2ERJA 2KMSA 1GPZA 2MCZA 3NFPI 1LY2A 1H2PP 2XWJI 2CG6A 2QY0A 1MD7A 1SS2A 1GKGA 4B2RA 4CSYA 3EJHA 1Q3XA 3KZJA 1SRZA 2EC3A 4DJZA 4A5WB 2G7IA 5HYTB 4YNXA 3L89M 1OJYA 4WJG2 1OJVA 3T5OA 3ZD1A 2IZ3A
chains in the Genus database with same CATH superfamily
3WSXA 4APLA 2JGXA 1H04P 3GXEA 4YIZA 4AYDA 1C1ZA 1VVDA 4ZH1D 3OXUD 2W81A 4LOSA 2YBYA 2CKUA 2BZMA 1G4GA 2MCYA 2I2LA 3IU3I 3M7PA 4PZ5A 2XQWC 1U5MA 2UWNA 3OP8A 1NWVA 2Y8SA 1E88A 2JRAA 4J38B 2O39C 1GKNA 1ZJKA 3K3TA 4MUCA 1OK9A 3RJ3D 1TPNA 2ZYCA 3FGRA 3TVJA 3VWOA 1H2QP 1OK1A 2XRBA 1OK3A 1CKLA 5HZPB 3INBC 4FXGG 1QGBA 4C16A 1E5GA 3IX0A 5JPMG 1HFIA 2A55A 3MQLA 2JGWA 3GOVA 2W80A 1GHQB 4AYEA 1TPMA 2KRIA 1HCCA 3ZLDA 1OJWA 4AYMA 4BWCA 1HFHA 1MD8A 3OEDC 3ERBA 2CG7A 3ZD2A 1TPGA 2RKYA 3ZRZA 1VVCA 1FBRA 2RLPA 4JHSA 1O9AA 4MSLA 2X2ZA 1G4FA 2XRDA 2EHFA 1OK2A 4IGDA 4K12A 4B2SA 3ZLEA 2YRAA 3FGTA 1RLHA 4ONTD 2V8EA 5I0QB 3O8EB 3SW0X 1UOTP 2IZ4A 2WIIC 4F4OC 4AYIA 1Z92B 5HYUB 1QO6A 5FO8C 1QUBA 4LOTA 1PPQA 2RKZA 3CALA 2RLQA 5HYPA 2B5ID 1H03P 1ELVA 2XWBF 1E8BA 2RL0A 3R62A 3CI0J 4KKDA 3KXVA 2LOJA 4PO7A 3WSYA 2ERJA 2KMSA 1GPZA 2MCZA 3NFPI 1LY2A 1H2PP 2XWJI 2CG6A 2QY0A 1MD7A 1SS2A 1GKGA 2Y8TA 4B2RA 4N7EA 3EJHA 2Y8RA 4CSYA 1Q3XA 3KZJA 3F6KA 1SRZA 2EC3A 4DJZA 3NJAA 2G7IA 4A5WB 4YNXA 3L89M 5HYTB 1OJYA 4WJG2 1OJVA 3T5OA 5DN5A 3ZD1A 2IZ3A 5DN4A
chains in the Genus database with same CATH topology
2JGXA 1H04P 3GXEA 4AYDA 1C1ZA 1VVDA 4ZH1D 3OXUD 2W81A 4LOSA 2YBYA 2CKUA 2BZMA 1G4GA 2MCYA 3IU3I 3M7PA 4PZ5A 2XQWC 1U5MA 2UWNA 3OP8A 1NWVA 1E88A 2JRAA 4J38B 2O39C 1GKNA 1ZJKA 4MUCA 1OK9A 3RJ3D 1TPNA 3TVJA 1H2QP 1OK1A 2XRBA 1OK3A 1CKLA 5HZPB 3INBC 4FXGG 1QGBA 4C16A 1E5GA 3IX0A 5JPMG 1HFIA 2A55A 3MQLA 2JGWA 3GOVA 2W80A 1GHQB 4AYEA 1TPMA 2KRIA 1HCCA 1OJWA 4AYMA 1HFHA 1MD8A 3OEDC 3ERBA 2CG7A 3ZD2A 1TPGA 2RKYA 3ZRZA 1VVCA 1FBRA 2RLPA 4JHSA 1O9AA 1G4FA 2XRDA 2EHFA 1OK2A 4IGDA 4K12A 4B2SA 2YRAA 4ONTD 2V8EA 5I0QB 3O8EB 3SW0X 1UOTP 2IZ4A 2WIIC 4F4OC 4AYIA 1Z92B 5HYUB 1QO6A 5FO8C 1QUBA 4LOTA 1PPQA 2RKZA 3CALA 2RLQA 5HYPA 2B5ID 1H03P 1ELVA 2XWBF 1E8BA 2RL0A 3R62A 4KKDA 3KXVA 2LOJA 2ERJA 2KMSA 1GPZA 2MCZA 3NFPI 1LY2A 1H2PP 2XWJI 2CG6A 2QY0A 1MD7A 1SS2A 1GKGA 4B2RA 4CSYA 3EJHA 1Q3XA 3KZJA 1SRZA 2EC3A 4DJZA 4A5WB 2G7IA 5HYTB 4YNXA 3L89M 1OJYA 4WJG2 1OJVA 3T5OA 3ZD1A 2IZ3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JGX A;  1H04 P;  3GXE A;  4AYD A;  1C1Z A;  1VVD A;  4ZH1 D;  3OXU D;  2W81 A;  4LOS A;  2YBY A;  2CKU A;  2BZM A;  1G4G A;  2MCY A;  3IU3 I;  3M7P A;  4PZ5 A;  2XQW C;  1U5M A;  2UWN A;  3OP8 A;  1NWV A;  1E88 A;  2JRA A;  4J38 B;  2O39 C;  1GKN A;  1ZJK A;  4MUC A;  1OK9 A;  3RJ3 D;  1TPN A;  3TVJ A;  1H2Q P;  1OK1 A;  2XRB A;  1OK3 A;  1CKL A;  5HZP B;  3INB C;  4FXG G;  1QGB A;  4C16 A;  1E5G A;  3IX0 A;  5JPM G;  1HFI A;  2A55 A;  3MQL A;  2JGW A;  3GOV A;  2W80 A;  1GHQ B;  4AYE A;  1TPM A;  2KRI A;  1HCC A;  1OJW A;  4AYM A;  1HFH A;  1MD8 A;  3OED C;  3ERB A;  2CG7 A;  3ZD2 A;  1TPG A;  2RKY A;  3ZRZ A;  1VVC A;  1FBR A;  2RLP A;  4JHS A;  1O9A A;  1G4F A;  2XRD A;  2EHF A;  1OK2 A;  4IGD A;  4K12 A;  4B2S A;  2YRA A;  4ONT D;  2V8E A;  5I0Q B;  3O8E B;  3SW0 X;  1UOT P;  2IZ4 A;  2WII C;  4F4O C;  4AYI A;  1Z92 B;  5HYU B;  1QO6 A;  5FO8 C;  1QUB A;  4LOT A;  1PPQ A;  2RKZ A;  3CAL A;  2RLQ A;  5HYP A;  2B5I D;  1H03 P;  1ELV A;  2XWB F;  1E8B A;  2RL0 A;  3R62 A;  4KKD A;  3KXV A;  2LOJ A;  2ERJ A;  2KMS A;  1GPZ A;  2MCZ A;  3NFP I;  1LY2 A;  1H2P P;  2XWJ I;  2CG6 A;  2QY0 A;  1MD7 A;  1SS2 A;  1GKG A;  4B2R A;  4CSY A;  3EJH A;  1Q3X A;  3KZJ A;  1SRZ A;  2EC3 A;  4DJZ A;  4A5W B;  2G7I A;  5HYT B;  4YNX A;  3L89 M;  1OJY A;  4WJG 2;  1OJV A;  3T5O A;  3ZD1 A;  2IZ3 A; 
#chains in the Genus database with same CATH topology
 3WSX A;  4APL A;  2JGX A;  1H04 P;  3GXE A;  4YIZ A;  4AYD A;  1C1Z A;  1VVD A;  4ZH1 D;  3OXU D;  2W81 A;  4LOS A;  2YBY A;  2CKU A;  2BZM A;  1G4G A;  2MCY A;  2I2L A;  3IU3 I;  3M7P A;  4PZ5 A;  2XQW C;  1U5M A;  2UWN A;  3OP8 A;  1NWV A;  2Y8S A;  1E88 A;  2JRA A;  4J38 B;  2O39 C;  1GKN A;  1ZJK A;  3K3T A;  4MUC A;  1OK9 A;  3RJ3 D;  1TPN A;  2ZYC A;  3FGR A;  3TVJ A;  3VWO A;  1H2Q P;  1OK1 A;  2XRB A;  1OK3 A;  1CKL A;  5HZP B;  3INB C;  4FXG G;  1QGB A;  4C16 A;  1E5G A;  3IX0 A;  5JPM G;  1HFI A;  2A55 A;  3MQL A;  2JGW A;  3GOV A;  2W80 A;  1GHQ B;  4AYE A;  1TPM A;  2KRI A;  1HCC A;  3ZLD A;  1OJW A;  4AYM A;  4BWC A;  1HFH A;  1MD8 A;  3OED C;  3ERB A;  2CG7 A;  3ZD2 A;  1TPG A;  2RKY A;  3ZRZ A;  1VVC A;  1FBR A;  2RLP A;  4JHS A;  1O9A A;  4MSL A;  2X2Z A;  1G4F A;  2XRD A;  2EHF A;  1OK2 A;  4IGD A;  4K12 A;  4B2S A;  3ZLE A;  2YRA A;  3FGT A;  1RLH A;  4ONT D;  2V8E A;  5I0Q B;  3O8E B;  3SW0 X;  1UOT P;  2IZ4 A;  2WII C;  4F4O C;  4AYI A;  1Z92 B;  5HYU B;  1QO6 A;  5FO8 C;  1QUB A;  4LOT A;  1PPQ A;  2RKZ A;  3CAL A;  2RLQ A;  5HYP A;  2B5I D;  1H03 P;  1ELV A;  2XWB F;  1E8B A;  2RL0 A;  3R62 A;  3CI0 J;  4KKD A;  3KXV A;  2LOJ A;  4PO7 A;  3WSY A;  2ERJ A;  2KMS A;  1GPZ A;  2MCZ A;  3NFP I;  1LY2 A;  1H2P P;  2XWJ I;  2CG6 A;  2QY0 A;  1MD7 A;  1SS2 A;  1GKG A;  2Y8T A;  4B2R A;  4N7E A;  3EJH A;  2Y8R A;  4CSY A;  1Q3X A;  3KZJ A;  3F6K A;  1SRZ A;  2EC3 A;  4DJZ A;  3NJA A;  2G7I A;  4A5W B;  4YNX A;  3L89 M;  5HYT B;  1OJY A;  4WJG 2;  1OJV A;  3T5O A;  5DN5 A;  3ZD1 A;  2IZ3 A;  5DN4 A; 
#chains in the Genus database with same CATH homology
 2JGX A;  1H04 P;  3GXE A;  4AYD A;  1C1Z A;  1VVD A;  4ZH1 D;  3OXU D;  2W81 A;  4LOS A;  2YBY A;  2CKU A;  2BZM A;  1G4G A;  2MCY A;  3IU3 I;  3M7P A;  4PZ5 A;  2XQW C;  1U5M A;  2UWN A;  3OP8 A;  1NWV A;  1E88 A;  2JRA A;  4J38 B;  2O39 C;  1GKN A;  1ZJK A;  4MUC A;  1OK9 A;  3RJ3 D;  1TPN A;  3TVJ A;  1H2Q P;  1OK1 A;  2XRB A;  1OK3 A;  1CKL A;  5HZP B;  3INB C;  4FXG G;  1QGB A;  4C16 A;  1E5G A;  3IX0 A;  5JPM G;  1HFI A;  2A55 A;  3MQL A;  2JGW A;  3GOV A;  2W80 A;  1GHQ B;  4AYE A;  1TPM A;  2KRI A;  1HCC A;  1OJW A;  4AYM A;  1HFH A;  1MD8 A;  3OED C;  3ERB A;  2CG7 A;  3ZD2 A;  1TPG A;  2RKY A;  3ZRZ A;  1VVC A;  1FBR A;  2RLP A;  4JHS A;  1O9A A;  1G4F A;  2XRD A;  2EHF A;  1OK2 A;  4IGD A;  4K12 A;  4B2S A;  2YRA A;  4ONT D;  2V8E A;  5I0Q B;  3O8E B;  3SW0 X;  1UOT P;  2IZ4 A;  2WII C;  4F4O C;  4AYI A;  1Z92 B;  5HYU B;  1QO6 A;  5FO8 C;  1QUB A;  4LOT A;  1PPQ A;  2RKZ A;  3CAL A;  2RLQ A;  5HYP A;  2B5I D;  1H03 P;  1ELV A;  2XWB F;  1E8B A;  2RL0 A;  3R62 A;  4KKD A;  3KXV A;  2LOJ A;  2ERJ A;  2KMS A;  1GPZ A;  2MCZ A;  3NFP I;  1LY2 A;  1H2P P;  2XWJ I;  2CG6 A;  2QY0 A;  1MD7 A;  1SS2 A;  1GKG A;  4B2R A;  4CSY A;  3EJH A;  1Q3X A;  3KZJ A;  1SRZ A;  2EC3 A;  4DJZ A;  4A5W B;  2G7I A;  5HYT B;  4YNX A;  3L89 M;  1OJY A;  4WJG 2;  1OJV A;  3T5O A;  3ZD1 A;  2IZ3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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