5JPMG

Structure of the complex of human complement c4 with masp-2 rebuilt using imdff
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
145
structure length
145
Chain Sequence
TAHACPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSART
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement C4-A
total genus 25
structure length 145
sequence length 145
chains with identical sequence I
ec nomenclature ec 3.4.21.104: Mannan-binding lectin-associated serine protease-2.
pdb deposition date 2016-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5jpmG02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5jpmG01
5FO8C 3T5OA 4K12A 1CKLA 3SW0X 1QUBA 1OJVA 2RLQA 1QO6A 2JRAA 4LOSA 1OJWA 3R62A 2IZ3A 1Z92B 1SS2A 1H2PP 2WIIC 4ONTD 1G4FA 2W81A 2XRBA 4AYIA 1OK9A 2KRIA 4B2SA 2EHFA 3OEDC 2RLPA 2MCYA 3CALA 4IGDA 1UOTP 3IX0A 4CSYA 1U5MA 5I0QB 1H03P 1SRZA 4FXGG 3INBC 1H04P 2KMSA 2O39C 1G4GA 2CG7A 1HCCA 4KKDA 2W80A 1TPMA 4AYDA 1E88A 2B5ID 5JPMG 2UWNA 2XWJI 1NWVA 4AYEA 1OJYA 2MCZA 2XRDA 4J38B 3O8EB 1VVDA 2IZ4A 4MUCA 2JGWA 5HZPB 1HFIA 1Q3XA 1MD8A 4ZH1D 1OK1A 2CKUA 1MD7A 3MQLA 3OP8A 1QGBA 1GPZA 3ERBA 2CG6A 1VVCA 2EC3A 3ZRZA 1E8BA 2LOJA 3RJ3D 1TPNA 1E5GA 5HYUB 2YRAA 2RKZA 2ERJA 1GKNA 4A5WB 1HFHA 4DJZA 2XQWC 3GXEA 5HYPA 2V8EA 3L89M 4JHSA 3M7PA 3ZD2A 2JGXA 4PZ5A 1LY2A 5HYTB 1OK2A 4B2RA 1GHQB 4WJG2 4AYMA 3KXVA 4LOTA 3OXUD 1O9AA 1OK3A 4F4OC 2BZMA 3NFPI 1ZJKA 2XWBF 1C1ZA 2G7IA 2RL0A 3GOVA 3EJHA 3KZJA 1GKGA 3IU3I 4C16A 1TPGA 4YNXA 1PPQA 2QY0A 1H2QP 3ZD1A 2A55A 3TVJA 1ELVA 2RKYA 2YBYA 1FBRA
chains in the Genus database with same CATH superfamily
4YIZA 5FO8C 3T5OA 4K12A 1CKLA 3SW0X 1QUBA 1OJVA 2I2LA 2RLQA 1QO6A 2JRAA 4LOSA 1OJWA 3R62A 5DN5A 2IZ3A 1Z92B 3WSYA 1SS2A 1H2PP 2WIIC 4ONTD 1G4FA 2W81A 2XRBA 3FGRA 1OK9A 2KRIA 4AYIA 4B2SA 2EHFA 3OEDC 2RLPA 2MCYA 4N7EA 3CALA 4IGDA 1UOTP 3IX0A 4CSYA 1U5MA 5I0QB 1H03P 1SRZA 3K3TA 4FXGG 2Y8RA 3INBC 1H04P 2KMSA 2O39C 1G4GA 2CG7A 1HCCA 4KKDA 2W80A 1TPMA 3VWOA 4AYDA 2B5ID 5JPMG 2UWNA 2XWJI 1NWVA 4AYEA 1OJYA 3FGTA 2MCZA 4MSLA 2XRDA 4J38B 3O8EB 1VVDA 2IZ4A 4MUCA 2JGWA 3NJAA 5HZPB 1HFIA 1Q3XA 1MD8A 4ZH1D 1OK1A 2CKUA 2Y8SA 1MD7A 3MQLA 3OP8A 1QGBA 1GPZA 3ERBA 2CG6A 2ZYCA 1VVCA 2EC3A 3ZRZA 1E8BA 2LOJA 3RJ3D 1TPNA 1E5GA 1E88A 5HYUB 2YRAA 4BWCA 2RKZA 2X2ZA 2ERJA 1GKNA 1RLHA 3F6KA 4A5WB 1HFHA 4DJZA 3ZLDA 2XQWC 3GXEA 5HYPA 2V8EA 3L89M 4JHSA 3M7PA 3ZD2A 2JGXA 4APLA 4PZ5A 1LY2A 5HYTB 5DN4A 1OK2A 4B2RA 1GHQB 4WJG2 4AYMA 3KXVA 4LOTA 3OXUD 1O9AA 1OK3A 4F4OC 2BZMA 3NFPI 1ZJKA 2XWBF 1C1ZA 2G7IA 2RL0A 3GOVA 3EJHA 2Y8TA 3KZJA 1GKGA 3IU3I 4C16A 1TPGA 3ZLEA 4YNXA 1PPQA 2QY0A 1H2QP 3ZD1A 3CI0J 2A55A 3WSXA 3TVJA 1ELVA 4PO7A 2RKYA 2YBYA 1FBRA
chains in the Genus database with same CATH topology
5FO8C 3T5OA 4K12A 1CKLA 3SW0X 1QUBA 1OJVA 2RLQA 1QO6A 2JRAA 4LOSA 1OJWA 3R62A 2IZ3A 1Z92B 1SS2A 1H2PP 2WIIC 4ONTD 1G4FA 2W81A 2XRBA 4AYIA 1OK9A 2KRIA 4B2SA 2EHFA 3OEDC 2RLPA 2MCYA 3CALA 4IGDA 1UOTP 3IX0A 4CSYA 1U5MA 5I0QB 1H03P 1SRZA 4FXGG 3INBC 1H04P 2KMSA 2O39C 1G4GA 2CG7A 1HCCA 4KKDA 2W80A 1TPMA 4AYDA 1E88A 2B5ID 5JPMG 2UWNA 2XWJI 1NWVA 4AYEA 1OJYA 2MCZA 2XRDA 4J38B 3O8EB 1VVDA 2IZ4A 4MUCA 2JGWA 5HZPB 1HFIA 1Q3XA 1MD8A 4ZH1D 1OK1A 2CKUA 1MD7A 3MQLA 3OP8A 1QGBA 1GPZA 3ERBA 2CG6A 1VVCA 2EC3A 3ZRZA 1E8BA 2LOJA 3RJ3D 1TPNA 1E5GA 5HYUB 2YRAA 2RKZA 2ERJA 1GKNA 4A5WB 1HFHA 4DJZA 2XQWC 3GXEA 5HYPA 2V8EA 3L89M 4JHSA 3M7PA 3ZD2A 2JGXA 4PZ5A 1LY2A 5HYTB 1OK2A 4B2RA 1GHQB 4WJG2 4AYMA 3KXVA 4LOTA 3OXUD 1O9AA 1OK3A 4F4OC 2BZMA 3NFPI 1ZJKA 2XWBF 1C1ZA 2G7IA 2RL0A 3GOVA 3EJHA 3KZJA 1GKGA 3IU3I 4C16A 1TPGA 4YNXA 1PPQA 2QY0A 1H2QP 3ZD1A 2A55A 3TVJA 1ELVA 2RKYA 2YBYA 1FBRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FO8 C;  3T5O A;  4K12 A;  1CKL A;  3SW0 X;  1QUB A;  1OJV A;  2RLQ A;  1QO6 A;  2JRA A;  4LOS A;  1OJW A;  3R62 A;  2IZ3 A;  1Z92 B;  1SS2 A;  1H2P P;  2WII C;  4ONT D;  1G4F A;  2W81 A;  2XRB A;  4AYI A;  1OK9 A;  2KRI A;  4B2S A;  2EHF A;  3OED C;  2RLP A;  2MCY A;  3CAL A;  4IGD A;  1UOT P;  3IX0 A;  4CSY A;  1U5M A;  5I0Q B;  1H03 P;  1SRZ A;  4FXG G;  3INB C;  1H04 P;  2KMS A;  2O39 C;  1G4G A;  2CG7 A;  1HCC A;  4KKD A;  2W80 A;  1TPM A;  4AYD A;  1E88 A;  2B5I D;  5JPM G;  2UWN A;  2XWJ I;  1NWV A;  4AYE A;  1OJY A;  2MCZ A;  2XRD A;  4J38 B;  3O8E B;  1VVD A;  2IZ4 A;  4MUC A;  2JGW A;  5HZP B;  1HFI A;  1Q3X A;  1MD8 A;  4ZH1 D;  1OK1 A;  2CKU A;  1MD7 A;  3MQL A;  3OP8 A;  1QGB A;  1GPZ A;  3ERB A;  2CG6 A;  1VVC A;  2EC3 A;  3ZRZ A;  1E8B A;  2LOJ A;  3RJ3 D;  1TPN A;  1E5G A;  5HYU B;  2YRA A;  2RKZ A;  2ERJ A;  1GKN A;  4A5W B;  1HFH A;  4DJZ A;  2XQW C;  3GXE A;  5HYP A;  2V8E A;  3L89 M;  4JHS A;  3M7P A;  3ZD2 A;  2JGX A;  4PZ5 A;  1LY2 A;  5HYT B;  1OK2 A;  4B2R A;  1GHQ B;  4WJG 2;  4AYM A;  3KXV A;  4LOT A;  3OXU D;  1O9A A;  1OK3 A;  4F4O C;  2BZM A;  3NFP I;  1ZJK A;  2XWB F;  1C1Z A;  2G7I A;  2RL0 A;  3GOV A;  3EJH A;  3KZJ A;  1GKG A;  3IU3 I;  4C16 A;  1TPG A;  4YNX A;  1PPQ A;  2QY0 A;  1H2Q P;  3ZD1 A;  2A55 A;  3TVJ A;  1ELV A;  2RKY A;  2YBY A;  1FBR A; 
#chains in the Genus database with same CATH topology
 4YIZ A;  5FO8 C;  3T5O A;  4K12 A;  1CKL A;  3SW0 X;  1QUB A;  1OJV A;  2I2L A;  2RLQ A;  1QO6 A;  2JRA A;  4LOS A;  1OJW A;  3R62 A;  5DN5 A;  2IZ3 A;  1Z92 B;  3WSY A;  1SS2 A;  1H2P P;  2WII C;  4ONT D;  1G4F A;  2W81 A;  2XRB A;  3FGR A;  1OK9 A;  2KRI A;  4AYI A;  4B2S A;  2EHF A;  3OED C;  2RLP A;  2MCY A;  4N7E A;  3CAL A;  4IGD A;  1UOT P;  3IX0 A;  4CSY A;  1U5M A;  5I0Q B;  1H03 P;  1SRZ A;  3K3T A;  4FXG G;  2Y8R A;  3INB C;  1H04 P;  2KMS A;  2O39 C;  1G4G A;  2CG7 A;  1HCC A;  4KKD A;  2W80 A;  1TPM A;  3VWO A;  4AYD A;  2B5I D;  5JPM G;  2UWN A;  2XWJ I;  1NWV A;  4AYE A;  1OJY A;  3FGT A;  2MCZ A;  4MSL A;  2XRD A;  4J38 B;  3O8E B;  1VVD A;  2IZ4 A;  4MUC A;  2JGW A;  3NJA A;  5HZP B;  1HFI A;  1Q3X A;  1MD8 A;  4ZH1 D;  1OK1 A;  2CKU A;  2Y8S A;  1MD7 A;  3MQL A;  3OP8 A;  1QGB A;  1GPZ A;  3ERB A;  2CG6 A;  2ZYC A;  1VVC A;  2EC3 A;  3ZRZ A;  1E8B A;  2LOJ A;  3RJ3 D;  1TPN A;  1E5G A;  1E88 A;  5HYU B;  2YRA A;  4BWC A;  2RKZ A;  2X2Z A;  2ERJ A;  1GKN A;  1RLH A;  3F6K A;  4A5W B;  1HFH A;  4DJZ A;  3ZLD A;  2XQW C;  3GXE A;  5HYP A;  2V8E A;  3L89 M;  4JHS A;  3M7P A;  3ZD2 A;  2JGX A;  4APL A;  4PZ5 A;  1LY2 A;  5HYT B;  5DN4 A;  1OK2 A;  4B2R A;  1GHQ B;  4WJG 2;  4AYM A;  3KXV A;  4LOT A;  3OXU D;  1O9A A;  1OK3 A;  4F4O C;  2BZM A;  3NFP I;  1ZJK A;  2XWB F;  1C1Z A;  2G7I A;  2RL0 A;  3GOV A;  3EJH A;  2Y8T A;  3KZJ A;  1GKG A;  3IU3 I;  4C16 A;  1TPG A;  3ZLE A;  4YNX A;  1PPQ A;  2QY0 A;  1H2Q P;  3ZD1 A;  3CI0 J;  2A55 A;  3WSX A;  3TVJ A;  1ELV A;  4PO7 A;  2RKY A;  2YBY A;  1FBR A; 
#chains in the Genus database with same CATH homology
 5FO8 C;  3T5O A;  4K12 A;  1CKL A;  3SW0 X;  1QUB A;  1OJV A;  2RLQ A;  1QO6 A;  2JRA A;  4LOS A;  1OJW A;  3R62 A;  2IZ3 A;  1Z92 B;  1SS2 A;  1H2P P;  2WII C;  4ONT D;  1G4F A;  2W81 A;  2XRB A;  4AYI A;  1OK9 A;  2KRI A;  4B2S A;  2EHF A;  3OED C;  2RLP A;  2MCY A;  3CAL A;  4IGD A;  1UOT P;  3IX0 A;  4CSY A;  1U5M A;  5I0Q B;  1H03 P;  1SRZ A;  4FXG G;  3INB C;  1H04 P;  2KMS A;  2O39 C;  1G4G A;  2CG7 A;  1HCC A;  4KKD A;  2W80 A;  1TPM A;  4AYD A;  1E88 A;  2B5I D;  5JPM G;  2UWN A;  2XWJ I;  1NWV A;  4AYE A;  1OJY A;  2MCZ A;  2XRD A;  4J38 B;  3O8E B;  1VVD A;  2IZ4 A;  4MUC A;  2JGW A;  5HZP B;  1HFI A;  1Q3X A;  1MD8 A;  4ZH1 D;  1OK1 A;  2CKU A;  1MD7 A;  3MQL A;  3OP8 A;  1QGB A;  1GPZ A;  3ERB A;  2CG6 A;  1VVC A;  2EC3 A;  3ZRZ A;  1E8B A;  2LOJ A;  3RJ3 D;  1TPN A;  1E5G A;  5HYU B;  2YRA A;  2RKZ A;  2ERJ A;  1GKN A;  4A5W B;  1HFH A;  4DJZ A;  2XQW C;  3GXE A;  5HYP A;  2V8E A;  3L89 M;  4JHS A;  3M7P A;  3ZD2 A;  2JGX A;  4PZ5 A;  1LY2 A;  5HYT B;  1OK2 A;  4B2R A;  1GHQ B;  4WJG 2;  4AYM A;  3KXV A;  4LOT A;  3OXU D;  1O9A A;  1OK3 A;  4F4O C;  2BZM A;  3NFP I;  1ZJK A;  2XWB F;  1C1Z A;  2G7I A;  2RL0 A;  3GOV A;  3EJH A;  3KZJ A;  1GKG A;  3IU3 I;  4C16 A;  1TPG A;  4YNX A;  1PPQ A;  2QY0 A;  1H2Q P;  3ZD1 A;  2A55 A;  3TVJ A;  1ELV A;  2RKY A;  2YBY A;  1FBR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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