1PYNA

Dual-site potent, selective protein tyrosine phosphatase 1b inhibitor using a linked fragment strategy and a malonate head on the first site
Total Genus 100
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
282
structure length
282
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Protein-tyrosine phosphatase, non-receptor type 1
total genus 100
structure length 282
sequence length 282
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2003-07-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 1pynA00
3CWEA 1YGRA 2HNPA 2QDMA 3QCNA 1T4JA 4BPCA 4NWGA 4NX8A 3V0EA 3RZ2A 3D9CA 1PA1A 2I6MA 4B04A 4DGXA 3QCBA 2OC3A 2F6VA 3QKPA 1YTWA 2QDCA 5KAAA 1NNYA 1ECVA 2J16A 3EU0A 2I3UA 1U26A 2I75A 2OZ5A 5KADA 3ZM2A 2HY3A 2QBSA 1D5RA 2NV5A 1VHRA 2J16B 5EHPA 4OHDA 2E0TA 4HJQA 3GXGA 2HC2A 1Q1MA 2PT0A 1C87A 3B7OA 3BRHA 4NYHA 3ZM0A 1NZ7A 2VEVA 3AWFA 2HB1A 2H04A 2OOQA 2NLKA 1ONYA 2I1YA 3S4OA 1C85A 4WU2A 2OUDA 5BX1A 1RPMA 1L8GA 1L8KA 2NTAA 4BJOA 2VEXA 1OESA 5KA1A 2F71A 2WGPA 3A5KA 4QUNA 1V3AA 1M3GA 2VEWA 4ZN5A 4HRFA 1YTNA 5BZXA 4RI4A 5KA8A 1YPTA 4AZ1A 4YAAA 2G59A 2I6OA 1OHEA 2PA5A 3QCJA 1G7GA 2F6FA 1PYNA 4MBBA 1OHCA 5KA7A 5K23A 4R0TA 2GP0A 1JLNA 4GE2A 1YFOA 2P4DA 4D3RA 4GFVA 3QKQA 1XRIA 1JF7A 2Y96A 3V0JA 1OEVA 3QCDA 1NWEA 1XM2A 1A5YA 4I8NA 2A3KA 2F6TA 1LQFA 3ZMQA 2CNFA 5K9VA 2C46A 5J8RA 3MOWA 2YDUA 2I3RA 2NT7A 2QCTA 2H4GA 3GXHA 2F6ZA 4H34A 2HVLA 4GRZA 4QBWA 2PQ5A 3V0GA 3S3HA 3BM8A 4TVVA 5KA4A 2AZRA 2R0BA 1G1GA 3H2XA 3OMHA 1ZCLA 3QCEA 2I6JA 1MKPA 2CFVA 1X24A 1PTVA 3QCKA 2I4EA 1G4WR 2NZ6A 5GTJA 1XXVA 2H4KA 3OLRA 2A8BA 2VEUA 2F70A 4Y2EA 4OHEA 5KA9A 3S3EA 4QBEA 3SR9A 2BZLA 1RXDA 3SMEA 3D1QA 4ICZA 5KACA 1FPRA 4H1OA 3AWEA 4QAPA 5KABA 2BV5A 3ZM3A 1Q6NA 2J17A 2FJMA 4OHHA 2DXPA 4Y14A 2I5XA 4S0GA 3V0IA 3ZMPA 3O5XA 1Q6SA 3S3KA 1T48A 2BGDA 3F41A 5AWXA 4KYRA 2F6WA 1GFYA 3I80A 3O4UA 1PXHA 3NMEA 1YGUA 3QCIA 3MMJA 2C7SA 1PH0A 1BZHA 4RDDA 3BLTA 4KI9A 2B4UA 4WOHA 3O3LA 5KA0A 3U96A 4KYQA 3V0FA 3N0AA 2I4GA 2BIJA 3V0HA 2NT2A 2H4VA 2Q05A 2QBRA 2RF6A 1WAXA 1G1HA 1QXKA 3EMUA 1EEOA 5IBMA 2CMBA 2CMCA 3S4EA 1T49A 2CJZA 1U25A 2JJDA 1P15A 2PSZA 1I9TA 2P6XA 3M4UA 1YZ4A 4JMJA 2B4SA 4NWFA 3QCFA 3I7ZA 1G1FA 1G4US 1XXPA 4Z6BA 4ZRTA 3O4TA 4GRYA 2HXPA 3F81A 2HNQA 4GFUA 1FQ1A 2SHPA 2AHSA 1U24A 4GS0A 1OEOX 1OEUA 2M3VA 2F46A 3I36A 5I6VA 2QBQA 4IKCA 2B3OA 1OEMX 4GE6A 4JNBA 2QDPA 3EZZA 1PTTA 2CNIA 3QCMA 1C83A 2IMGA 2I42A 5K25A 2FH7A 4ERCA 4JBCA 1EENA 1XBOA 2QEPA 3D44A 1G7FA 2B4PA 1C86A 2B07A 4WTYA 2B49A 2GWOA 5LXQB 3CM3A 1QZ0A 3QCHA 2I6IA 3F9AA 4GWFA 1Q6JA 1SUGA 1OHDA 3RGOA 2GJTA 1PA9A 2CM7A 1Q6TA 4RH9A 1AAXA 3D1HA 2ESBA 3F99A 2PI7A 5K22A 3A5JA 4JMKA 4HJPA 3MOZA 3RO1A 3LJ8A 4OHLA 1NO6A 4NNDA 2CMAA 4RHGA 5IBSA 2HC1A 2H02A 1WCHA 1ZCKA 5HDEA 4DGPA 4D3QA 1ZC0A 4R30A 3BLUA 1R6HA 2ZN7A 3QCLA 4ZI4A 4QUMA 2H03A 4OHIA 5KA3A 4RKKA 2MBCA 2ZMMA 5BUGA 2F6YA 2CNHA 1ONZA 1YWFA 3F9BA 1Q6MA 2QCJA 1BZJA 2Q47A 2I4HA 1KAKA 2CM3A 1I9SA 2FJNA 3QCGA 2VEYA 1C84A 5K24A 4D3PA 1I57A 2QBPA 1LARA 2B4OA 4GE5A 1YTSA 1NWLA 5MMZB 3AWGA 2PBNA 3D1OA 1PTUA 1PTYA 1NL9A 2CM2A 4PVGA 2BGEA 4R0SA 1KAVA 4RI5A 3O4SA 3D42A 4RH5A 1WRMA 2HCMA 3PS5A 2CNGA 1OETA 1LYVA 1YN9A 4WU3A 1Q6PA 3V0DA 3ZM1A 5M43A 1C88A 3RGQA 2CM8A 2CNEA 1J4XA 4QAHA 3EB1A 3EAXA 5K9WA 3ZV2A 1FPZA 2Y2FA 5EHRA 1GWZA 1BZCA 4J51A 5BZZA 4YR8B 2I6PA 5KA2A 3S3FA 1ZZWA 3QCCA 4PYHA 2G6ZA
chains in the Genus database with same CATH superfamily
3CWEA 2Y68A 1YGRA 1JBVA 2HNPA 2QDMA 3QCNA 1T4JA 4BUBA 4BPCA 4NWGA 4NX8A 3UAGA 3V0EA 3RZ2A 3D9CA 1PA1A 2I6MA 4B04A 4DGXA 3QCBA 2OC3A 2F6VA 3QKPA 1YTWA 2QDCA 5KAAA 4CVLA 1NNYA 1ECVA 2J16A 2UUPA 3EU0A 2I3UA 1U26A 2I75A 2OZ5A 5A5EA 5KADA 3ZM2A 2HY3A 2QBSA 1D5RA 2NV5A 1VHRA 2J16B 5EHPA 4OHDA 2E0TA 4HJQA 3GXGA 2HC2A 1Q1MA 3LK7A 2PT0A 1C87A 3B7OA 3BRHA 4NYHA 3ZM0A 1NZ7A 4UAGA 2VEVA 3AWFA 2HB1A 3ZM5A 2H04A 2OOQA 2NLKA 1ONYA 2I1YA 2UUOA 3S4OA 1C85A 4WU2A 2OUDA 5BX1A 1RPMA 2GCAA 1L8GA 1L8KA 2XJAA 4QDIA 1P31A 2NTAA 4BJOA 2VEXA 1OESA 5KA1A 2F71A 2WGPA 3A5KA 4QUNA 1V3AA 1M3GA 2VEWA 4ZN5A 4HRFA 1YTNA 2UAGA 5BZXA 2X5OA 4RI4A 5KA8A 1YPTA 2AM1A 4AZ1A 4YAAA 2G59A 2I6OA 1OHEA 2PA5A 3QCJA 1G7GA 2F6FA 1PYNA 4MBBA 1W7KA 1P3DA 1OHCA 2VOSA 5KA7A 5K23A 4R0TA 2GP0A 1E8CA 1JLNA 4GE2A 1YFOA 2P4DA 4D3RA 4C12A 4GFVA 3QKQA 1XRIA 1JF7A 2Y96A 3V0JA 1OEVA 3QCDA 1NWEA 1XM2A 1A5YA 4I8NA 2A3KA 2F6TA 1LQFA 3ZMQA 2CNFA 5K9VA 2C46A 5J8RA 3MOWA 4QF5A 2YDUA 2I3RA 2NT7A 2QCTA 2H4GA 3GXHA 2F6ZA 4H34A 2HVLA 4GRZA 4QBWA 2PQ5A 3V0GA 3S3HA 3BM8A 4TVVA 4HV4A 1E0DA 2JFHA 2GCBA 2WJPA 5KA4A 2AZRA 2VTDA 2R0BA 1G1GA 3H2XA 2VORA 3OMHA 1ZCLA 3QCEA 4CVKA 2I6JA 1MKPA 2CFVA 1X24A 1PTVA 3QCKA 2I4EA 1G4WR 2NZ6A 5GTJA 1XXVA 2F00A 2H4KA 3OLRA 2A8BA 2VEUA 2F70A 4Y2EA 1GQYA 4OHEA 5KA9A 3S3EA 4QBEA 3SR9A 2BZLA 1RXDA 3SMEA 3D1QA 4ICZA 2XPCA 1FPRA 5KACA 4H1OA 2JFGA 3AWEA 4QAPA 5KABA 1O5ZA 2BV5A 1Q6NA 3ZM3A 2J17A 2FJMA 4OHHA 2DXPA 4Y14A 2GC5A 2I5XA 2Y67A 4S0GA 3V0IA 3ZMPA 3O5XA 1Q6SA 3S3KA 1T48A 2BGDA 3F41A 5AWXA 4KYRA 2F6WA 1GFYA 3I80A 3O4UA 1PXHA 3NMEA 1YGUA 3QCIA 4ZIYA 3MMJA 2C7SA 1PH0A 1BZHA 4RDDA 3BLTA 4KI9A 2B4UA 4WOHA 3O3LA 5KA0A 3U96A 1GG4A 4KYQA 3V0FA 4CVMA 3N0AA 2I4GA 2BIJA 3V0HA 2NT2A 2H4VA 2Q05A 2QBRA 2RF6A 1WAXA 1G1HA 1QXKA 3EMUA 1EEOA 1J6UA 5IBMA 2CMBA 2CMCA 3S4EA 1T49A 2CJZA 1U25A 2JJDA 1P15A 2WTZA 2PSZA 1I9TA 2P6XA 3M4UA 1YZ4A 4JMJA 2B4SA 1JBWA 4NWFA 3QCFA 3I7ZA 1G1FA 1G4US 1XXPA 4Z6BA 3QCZA 4ZRTA 3O4TA 4GRYA 2HXPA 3F81A 2HNQA 4GFUA 1FQ1A 2SHPA 2AHSA 1U24A 4GS0A 1OEOX 1OEUA 2M3VA 2F46A 3I36A 5I6VA 2QBQA 4IKCA 2B3OA 1OEMX 4GE6A 4JNBA 2QDPA 3EZZA 1PTTA 2CNIA 3QCMA 1C83A 2IMGA 2I42A 5K25A 2FH7A 4ERCA 4JBCA 1EENA 1XBOA 2QEPA 3D44A 3HN7A 1G7FA 2B4PA 1C86A 2B07A 4WTYA 2B49A 2GWOA 5LXQB 3CM3A 1QZ0A 3QCHA 1W78A 2I6IA 3F9AA 2VTEA 4GWFA 1Q6JA 1SUGA 1OHDA 3RGOA 2GJTA 1PA9A 2CM7A 1Q6TA 4RH9A 1AAXA 3D1HA 2ESBA 3F99A 2PI7A 5K22A 3MVNA 3A5JA 4JMKA 4HJPA 3MOZA 3RO1A 3LJ8A 4OHLA 1NO6A 4NNDA 2CMAA 4RHGA 5IBSA 2HC1A 2H02A 1WCHA 1ZCKA 5HDEA 4DGPA 4D3QA 1ZC0A 4R30A 4C13A 2Y1OA 1UAGA 1FGSA 3BLUA 1R6HA 2ZN7A 3QCLA 4ZI4A 4QUMA 2H03A 3NRSA 4OHIA 5KA3A 4RKKA 2MBCA 2ZMMA 5BUGA 2F6YA 2CNHA 1ONZA 1YWFA 5A5FA 3F9BA 1Q6MA 2QCJA 1BZJA 2Q47A 2I4HA 1KAKA 2CM3A 1I9SA 2FJNA 3ZM6A 3QCGA 2VEYA 1C84A 5K24A 4D3PA 1I57A 2QBPA 1LARA 2AM2A 2B4OA 4GE5A 1YTSA 1NWLA 5MMZB 3AWGA 3PYZA 3N2AA 2PBNA 3D1OA 1PTUA 1PTYA 1NL9A 2CM2A 4PVGA 3ZL8A 2BGEA 4R0SA 1KAVA 4RI5A 3O4SA 3D42A 4RH5A 1WRMA 2HCMA 3PS5A 2CNGA 1OETA 1LYVA 1YN9A 4WU3A 1Q6PA 3V0DA 3ZM1A 5M43A 1C88A 2GC6A 3RGQA 2Y66A 2CM8A 2CNEA 4BUCA 1J4XA 4QAHA 3EB1A 1EEHA 3EAXA 5K9WA 3ZV2A 1FPZA 2Y2FA 5EHRA 2JFFA 1GWZA 1BZCA 4J51A 5BZZA 1GQQA 4YR8B 2I6PA 5KA2A 3S3FA 1ZZWA 3QCCA 4PYHA 2G6ZA
chains in the Genus database with same CATH topology
3CWEA 1YGRA 2HNPA 2QDMA 3QCNA 1T4JA 4BPCA 4NWGA 4NX8A 3V0EA 3RZ2A 3D9CA 1PA1A 2I6MA 4B04A 4DGXA 3QCBA 2OC3A 2F6VA 3QKPA 1YTWA 2QDCA 5KAAA 1NNYA 1ECVA 2J16A 3EU0A 2I3UA 1U26A 2I75A 2OZ5A 5KADA 3ZM2A 2HY3A 2QBSA 1D5RA 2NV5A 1VHRA 2J16B 5EHPA 4OHDA 2E0TA 4HJQA 3GXGA 2HC2A 1Q1MA 2PT0A 1C87A 3B7OA 3BRHA 4NYHA 3ZM0A 1NZ7A 2VEVA 3AWFA 2HB1A 2H04A 2OOQA 2NLKA 1ONYA 2I1YA 3S4OA 1C85A 4WU2A 2OUDA 5BX1A 1RPMA 1L8GA 1L8KA 2NTAA 4BJOA 2VEXA 1OESA 5KA1A 2F71A 2WGPA 3A5KA 4QUNA 1V3AA 1M3GA 2VEWA 4ZN5A 4HRFA 1YTNA 5BZXA 4RI4A 5KA8A 1YPTA 4AZ1A 4YAAA 2G59A 2I6OA 1OHEA 2PA5A 3QCJA 1G7GA 2F6FA 1PYNA 4MBBA 1OHCA 5KA7A 5K23A 4R0TA 2GP0A 1JLNA 4GE2A 1YFOA 2P4DA 4D3RA 4GFVA 3QKQA 1XRIA 1JF7A 2Y96A 3V0JA 1OEVA 3QCDA 1NWEA 1XM2A 1A5YA 4I8NA 2A3KA 2F6TA 1LQFA 3ZMQA 2CNFA 5K9VA 2C46A 5J8RA 3MOWA 2YDUA 2I3RA 2NT7A 2QCTA 2H4GA 3GXHA 2F6ZA 4H34A 2HVLA 4GRZA 4QBWA 2PQ5A 3V0GA 3S3HA 3BM8A 4TVVA 5KA4A 2AZRA 2R0BA 1G1GA 3H2XA 3OMHA 1ZCLA 3QCEA 2I6JA 1MKPA 2CFVA 1X24A 1PTVA 3QCKA 2I4EA 1G4WR 2NZ6A 5GTJA 1XXVA 2H4KA 3OLRA 2A8BA 2VEUA 2F70A 4Y2EA 4OHEA 5KA9A 3S3EA 4QBEA 3SR9A 2BZLA 1RXDA 3SMEA 3D1QA 4ICZA 5KACA 1FPRA 4H1OA 3AWEA 4QAPA 5KABA 2BV5A 3ZM3A 1Q6NA 2J17A 2FJMA 4OHHA 2DXPA 4Y14A 2I5XA 4S0GA 3V0IA 3ZMPA 3O5XA 1Q6SA 3S3KA 1T48A 2BGDA 3F41A 5AWXA 4KYRA 2F6WA 1GFYA 3I80A 3O4UA 1PXHA 3NMEA 1YGUA 3QCIA 3MMJA 2C7SA 1PH0A 1BZHA 4RDDA 3BLTA 4KI9A 2B4UA 4WOHA 3O3LA 5KA0A 3U96A 4KYQA 3V0FA 3N0AA 2I4GA 2BIJA 3V0HA 2NT2A 2H4VA 2Q05A 2QBRA 2RF6A 1WAXA 1G1HA 1QXKA 3EMUA 1EEOA 5IBMA 2CMBA 2CMCA 3S4EA 1T49A 2CJZA 1U25A 2JJDA 1P15A 2PSZA 1I9TA 2P6XA 3M4UA 1YZ4A 4JMJA 2B4SA 4NWFA 3QCFA 3I7ZA 1G1FA 1G4US 1XXPA 4Z6BA 4ZRTA 3O4TA 4GRYA 2HXPA 3F81A 2HNQA 4GFUA 1FQ1A 2SHPA 2AHSA 1U24A 4GS0A 1OEOX 1OEUA 2M3VA 2F46A 3I36A 5I6VA 2QBQA 4IKCA 2B3OA 1OEMX 4GE6A 4JNBA 2QDPA 3EZZA 1PTTA 2CNIA 3QCMA 1C83A 2IMGA 2I42A 5K25A 2FH7A 4ERCA 4JBCA 1EENA 1XBOA 2QEPA 3D44A 1G7FA 2B4PA 1C86A 2B07A 4WTYA 2B49A 2GWOA 5LXQB 3CM3A 1QZ0A 3QCHA 2I6IA 3F9AA 4GWFA 1Q6JA 1SUGA 1OHDA 3RGOA 2GJTA 1PA9A 2CM7A 1Q6TA 4RH9A 1AAXA 3D1HA 2ESBA 3F99A 2PI7A 5K22A 3A5JA 4JMKA 4HJPA 3MOZA 3RO1A 3LJ8A 4OHLA 1NO6A 4NNDA 2CMAA 4RHGA 5IBSA 2HC1A 2H02A 1WCHA 1ZCKA 5HDEA 4DGPA 4D3QA 1ZC0A 4R30A 3BLUA 1R6HA 2ZN7A 3QCLA 4ZI4A 4QUMA 2H03A 4OHIA 5KA3A 4RKKA 2MBCA 2ZMMA 5BUGA 2F6YA 2CNHA 1ONZA 1YWFA 3F9BA 1Q6MA 2QCJA 1BZJA 2Q47A 2I4HA 1KAKA 2CM3A 1I9SA 2FJNA 3QCGA 2VEYA 1C84A 5K24A 4D3PA 1I57A 2QBPA 1LARA 2B4OA 4GE5A 1YTSA 1NWLA 5MMZB 3AWGA 2PBNA 3D1OA 1PTUA 1PTYA 1NL9A 2CM2A 4PVGA 2BGEA 4R0SA 1KAVA 4RI5A 3O4SA 3D42A 4RH5A 1WRMA 2HCMA 3PS5A 2CNGA 1OETA 1LYVA 1YN9A 4WU3A 1Q6PA 3V0DA 3ZM1A 5M43A 1C88A 3RGQA 2CM8A 2CNEA 1J4XA 4QAHA 3EB1A 3EAXA 5K9WA 3ZV2A 1FPZA 2Y2FA 5EHRA 1GWZA 1BZCA 4J51A 5BZZA 4YR8B 2I6PA 5KA2A 3S3FA 1ZZWA 3QCCA 4PYHA 2G6ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CWE A;  1YGR A;  2HNP A;  2QDM A;  3QCN A;  1T4J A;  4BPC A;  4NWG A;  4NX8 A;  3V0E A;  3RZ2 A;  3D9C A;  1PA1 A;  2I6M A;  4B04 A;  4DGX A;  3QCB A;  2OC3 A;  2F6V A;  3QKP A;  1YTW A;  2QDC A;  5KAA A;  1NNY A;  1ECV A;  2J16 A;  3EU0 A;  2I3U A;  1U26 A;  2I75 A;  2OZ5 A;  5KAD A;  3ZM2 A;  2HY3 A;  2QBS A;  1D5R A;  2NV5 A;  1VHR A;  2J16 B;  5EHP A;  4OHD A;  2E0T A;  4HJQ A;  3GXG A;  2HC2 A;  1Q1M A;  2PT0 A;  1C87 A;  3B7O A;  3BRH A;  4NYH A;  3ZM0 A;  1NZ7 A;  2VEV A;  3AWF A;  2HB1 A;  2H04 A;  2OOQ A;  2NLK A;  1ONY A;  2I1Y A;  3S4O A;  1C85 A;  4WU2 A;  2OUD A;  5BX1 A;  1RPM A;  1L8G A;  1L8K A;  2NTA A;  4BJO A;  2VEX A;  1OES A;  5KA1 A;  2F71 A;  2WGP A;  3A5K A;  4QUN A;  1V3A A;  1M3G A;  2VEW A;  4ZN5 A;  4HRF A;  1YTN A;  5BZX A;  4RI4 A;  5KA8 A;  1YPT A;  4AZ1 A;  4YAA A;  2G59 A;  2I6O A;  1OHE A;  2PA5 A;  3QCJ A;  1G7G A;  2F6F A;  1PYN A;  4MBB A;  1OHC A;  5KA7 A;  5K23 A;  4R0T A;  2GP0 A;  1JLN A;  4GE2 A;  1YFO A;  2P4D A;  4D3R A;  4GFV A;  3QKQ A;  1XRI A;  1JF7 A;  2Y96 A;  3V0J A;  1OEV A;  3QCD A;  1NWE A;  1XM2 A;  1A5Y A;  4I8N A;  2A3K A;  2F6T A;  1LQF A;  3ZMQ A;  2CNF A;  5K9V A;  2C46 A;  5J8R A;  3MOW A;  2YDU A;  2I3R A;  2NT7 A;  2QCT A;  2H4G A;  3GXH A;  2F6Z A;  4H34 A;  2HVL A;  4GRZ A;  4QBW A;  2PQ5 A;  3V0G A;  3S3H A;  3BM8 A;  4TVV A;  5KA4 A;  2AZR A;  2R0B A;  1G1G A;  3H2X A;  3OMH A;  1ZCL A;  3QCE A;  2I6J A;  1MKP A;  2CFV A;  1X24 A;  1PTV A;  3QCK A;  2I4E A;  1G4W R;  2NZ6 A;  5GTJ A;  1XXV A;  2H4K A;  3OLR A;  2A8B A;  2VEU A;  2F70 A;  4Y2E A;  4OHE A;  5KA9 A;  3S3E A;  4QBE A;  3SR9 A;  2BZL A;  1RXD A;  3SME A;  3D1Q A;  4ICZ A;  5KAC A;  1FPR A;  4H1O A;  3AWE A;  4QAP A;  5KAB A;  2BV5 A;  3ZM3 A;  1Q6N A;  2J17 A;  2FJM A;  4OHH A;  2DXP A;  4Y14 A;  2I5X A;  4S0G A;  3V0I A;  3ZMP A;  3O5X A;  1Q6S A;  3S3K A;  1T48 A;  2BGD A;  3F41 A;  5AWX A;  4KYR A;  2F6W A;  1GFY A;  3I80 A;  3O4U A;  1PXH A;  3NME A;  1YGU A;  3QCI A;  3MMJ A;  2C7S A;  1PH0 A;  1BZH A;  4RDD A;  3BLT A;  4KI9 A;  2B4U A;  4WOH A;  3O3L A;  5KA0 A;  3U96 A;  4KYQ A;  3V0F A;  3N0A A;  2I4G A;  2BIJ A;  3V0H A;  2NT2 A;  2H4V A;  2Q05 A;  2QBR A;  2RF6 A;  1WAX A;  1G1H A;  1QXK A;  3EMU A;  1EEO A;  5IBM A;  2CMB A;  2CMC A;  3S4E A;  1T49 A;  2CJZ A;  1U25 A;  2JJD A;  1P15 A;  2PSZ A;  1I9T A;  2P6X A;  3M4U A;  1YZ4 A;  4JMJ A;  2B4S A;  4NWF A;  3QCF A;  3I7Z A;  1G1F A;  1G4U S;  1XXP A;  4Z6B A;  4ZRT A;  3O4T A;  4GRY A;  2HXP A;  3F81 A;  2HNQ A;  4GFU A;  1FQ1 A;  2SHP A;  2AHS A;  1U24 A;  4GS0 A;  1OEO X;  1OEU A;  2M3V A;  2F46 A;  3I36 A;  5I6V A;  2QBQ A;  4IKC A;  2B3O A;  1OEM X;  4GE6 A;  4JNB A;  2QDP A;  3EZZ A;  1PTT A;  2CNI A;  3QCM A;  1C83 A;  2IMG A;  2I42 A;  5K25 A;  2FH7 A;  4ERC A;  4JBC A;  1EEN A;  1XBO A;  2QEP A;  3D44 A;  1G7F A;  2B4P A;  1C86 A;  2B07 A;  4WTY A;  2B49 A;  2GWO A;  5LXQ B;  3CM3 A;  1QZ0 A;  3QCH A;  2I6I A;  3F9A A;  4GWF A;  1Q6J A;  1SUG A;  1OHD A;  3RGO A;  2GJT A;  1PA9 A;  2CM7 A;  1Q6T A;  4RH9 A;  1AAX A;  3D1H A;  2ESB A;  3F99 A;  2PI7 A;  5K22 A;  3A5J A;  4JMK A;  4HJP A;  3MOZ A;  3RO1 A;  3LJ8 A;  4OHL A;  1NO6 A;  4NND A;  2CMA A;  4RHG A;  5IBS A;  2HC1 A;  2H02 A;  1WCH A;  1ZCK A;  5HDE A;  4DGP A;  4D3Q A;  1ZC0 A;  4R30 A;  3BLU A;  1R6H A;  2ZN7 A;  3QCL A;  4ZI4 A;  4QUM A;  2H03 A;  4OHI A;  5KA3 A;  4RKK A;  2MBC A;  2ZMM A;  5BUG A;  2F6Y A;  2CNH A;  1ONZ A;  1YWF A;  3F9B A;  1Q6M A;  2QCJ A;  1BZJ A;  2Q47 A;  2I4H A;  1KAK A;  2CM3 A;  1I9S A;  2FJN A;  3QCG A;  2VEY A;  1C84 A;  5K24 A;  4D3P A;  1I57 A;  2QBP A;  1LAR A;  2B4O A;  4GE5 A;  1YTS A;  1NWL A;  5MMZ B;  3AWG A;  2PBN A;  3D1O A;  1PTU A;  1PTY A;  1NL9 A;  2CM2 A;  4PVG A;  2BGE A;  4R0S A;  1KAV A;  4RI5 A;  3O4S A;  3D42 A;  4RH5 A;  1WRM A;  2HCM A;  3PS5 A;  2CNG A;  1OET A;  1LYV A;  1YN9 A;  4WU3 A;  1Q6P A;  3V0D A;  3ZM1 A;  5M43 A;  1C88 A;  3RGQ A;  2CM8 A;  2CNE A;  1J4X A;  4QAH A;  3EB1 A;  3EAX A;  5K9W A;  3ZV2 A;  1FPZ A;  2Y2F A;  5EHR A;  1GWZ A;  1BZC A;  4J51 A;  5BZZ A;  4YR8 B;  2I6P A;  5KA2 A;  3S3F A;  1ZZW A;  3QCC A;  4PYH A;  2G6Z A; 
#chains in the Genus database with same CATH topology
 3CWE A;  2Y68 A;  1YGR A;  1JBV A;  2HNP A;  2QDM A;  3QCN A;  1T4J A;  4BUB A;  4BPC A;  4NWG A;  4NX8 A;  3UAG A;  3V0E A;  3RZ2 A;  3D9C A;  1PA1 A;  2I6M A;  4B04 A;  4DGX A;  3QCB A;  2OC3 A;  2F6V A;  3QKP A;  1YTW A;  2QDC A;  5KAA A;  4CVL A;  1NNY A;  1ECV A;  2J16 A;  2UUP A;  3EU0 A;  2I3U A;  1U26 A;  2I75 A;  2OZ5 A;  5A5E A;  5KAD A;  3ZM2 A;  2HY3 A;  2QBS A;  1D5R A;  2NV5 A;  1VHR A;  2J16 B;  5EHP A;  4OHD A;  2E0T A;  4HJQ A;  3GXG A;  2HC2 A;  1Q1M A;  3LK7 A;  2PT0 A;  1C87 A;  3B7O A;  3BRH A;  4NYH A;  3ZM0 A;  1NZ7 A;  4UAG A;  2VEV A;  3AWF A;  2HB1 A;  3ZM5 A;  2H04 A;  2OOQ A;  2NLK A;  1ONY A;  2I1Y A;  2UUO A;  3S4O A;  1C85 A;  4WU2 A;  2OUD A;  5BX1 A;  1RPM A;  2GCA A;  1L8G A;  1L8K A;  2XJA A;  4QDI A;  1P31 A;  2NTA A;  4BJO A;  2VEX A;  1OES A;  5KA1 A;  2F71 A;  2WGP A;  3A5K A;  4QUN A;  1V3A A;  1M3G A;  2VEW A;  4ZN5 A;  4HRF A;  1YTN A;  2UAG A;  5BZX A;  2X5O A;  4RI4 A;  5KA8 A;  1YPT A;  2AM1 A;  4AZ1 A;  4YAA A;  2G59 A;  2I6O A;  1OHE A;  2PA5 A;  3QCJ A;  1G7G A;  2F6F A;  1PYN A;  4MBB A;  1W7K A;  1P3D A;  1OHC A;  2VOS A;  5KA7 A;  5K23 A;  4R0T A;  2GP0 A;  1E8C A;  1JLN A;  4GE2 A;  1YFO A;  2P4D A;  4D3R A;  4C12 A;  4GFV A;  3QKQ A;  1XRI A;  1JF7 A;  2Y96 A;  3V0J A;  1OEV A;  3QCD A;  1NWE A;  1XM2 A;  1A5Y A;  4I8N A;  2A3K A;  2F6T A;  1LQF A;  3ZMQ A;  2CNF A;  5K9V A;  2C46 A;  5J8R A;  3MOW A;  4QF5 A;  2YDU A;  2I3R A;  2NT7 A;  2QCT A;  2H4G A;  3GXH A;  2F6Z A;  4H34 A;  2HVL A;  4GRZ A;  4QBW A;  2PQ5 A;  3V0G A;  3S3H A;  3BM8 A;  4TVV A;  4HV4 A;  1E0D A;  2JFH A;  2GCB A;  2WJP A;  5KA4 A;  2AZR A;  2VTD A;  2R0B A;  1G1G A;  3H2X A;  2VOR A;  3OMH A;  1ZCL A;  3QCE A;  4CVK A;  2I6J A;  1MKP A;  2CFV A;  1X24 A;  1PTV A;  3QCK A;  2I4E A;  1G4W R;  2NZ6 A;  5GTJ A;  1XXV A;  2F00 A;  2H4K A;  3OLR A;  2A8B A;  2VEU A;  2F70 A;  4Y2E A;  1GQY A;  4OHE A;  5KA9 A;  3S3E A;  4QBE A;  3SR9 A;  2BZL A;  1RXD A;  3SME A;  3D1Q A;  4ICZ A;  2XPC A;  1FPR A;  5KAC A;  4H1O A;  2JFG A;  3AWE A;  4QAP A;  5KAB A;  1O5Z A;  2BV5 A;  1Q6N A;  3ZM3 A;  2J17 A;  2FJM A;  4OHH A;  2DXP A;  4Y14 A;  2GC5 A;  2I5X A;  2Y67 A;  4S0G A;  3V0I A;  3ZMP A;  3O5X A;  1Q6S A;  3S3K A;  1T48 A;  2BGD A;  3F41 A;  5AWX A;  4KYR A;  2F6W A;  1GFY A;  3I80 A;  3O4U A;  1PXH A;  3NME A;  1YGU A;  3QCI A;  4ZIY A;  3MMJ A;  2C7S A;  1PH0 A;  1BZH A;  4RDD A;  3BLT A;  4KI9 A;  2B4U A;  4WOH A;  3O3L A;  5KA0 A;  3U96 A;  1GG4 A;  4KYQ A;  3V0F A;  4CVM A;  3N0A A;  2I4G A;  2BIJ A;  3V0H A;  2NT2 A;  2H4V A;  2Q05 A;  2QBR A;  2RF6 A;  1WAX A;  1G1H A;  1QXK A;  3EMU A;  1EEO A;  1J6U A;  5IBM A;  2CMB A;  2CMC A;  3S4E A;  1T49 A;  2CJZ A;  1U25 A;  2JJD A;  1P15 A;  2WTZ A;  2PSZ A;  1I9T A;  2P6X A;  3M4U A;  1YZ4 A;  4JMJ A;  2B4S A;  1JBW A;  4NWF A;  3QCF A;  3I7Z A;  1G1F A;  1G4U S;  1XXP A;  4Z6B A;  3QCZ A;  4ZRT A;  3O4T A;  4GRY A;  2HXP A;  3F81 A;  2HNQ A;  4GFU A;  1FQ1 A;  2SHP A;  2AHS A;  1U24 A;  4GS0 A;  1OEO X;  1OEU A;  2M3V A;  2F46 A;  3I36 A;  5I6V A;  2QBQ A;  4IKC A;  2B3O A;  1OEM X;  4GE6 A;  4JNB A;  2QDP A;  3EZZ A;  1PTT A;  2CNI A;  3QCM A;  1C83 A;  2IMG A;  2I42 A;  5K25 A;  2FH7 A;  4ERC A;  4JBC A;  1EEN A;  1XBO A;  2QEP A;  3D44 A;  3HN7 A;  1G7F A;  2B4P A;  1C86 A;  2B07 A;  4WTY A;  2B49 A;  2GWO A;  5LXQ B;  3CM3 A;  1QZ0 A;  3QCH A;  1W78 A;  2I6I A;  3F9A A;  2VTE A;  4GWF A;  1Q6J A;  1SUG A;  1OHD A;  3RGO A;  2GJT A;  1PA9 A;  2CM7 A;  1Q6T A;  4RH9 A;  1AAX A;  3D1H A;  2ESB A;  3F99 A;  2PI7 A;  5K22 A;  3MVN A;  3A5J A;  4JMK A;  4HJP A;  3MOZ A;  3RO1 A;  3LJ8 A;  4OHL A;  1NO6 A;  4NND A;  2CMA A;  4RHG A;  5IBS A;  2HC1 A;  2H02 A;  1WCH A;  1ZCK A;  5HDE A;  4DGP A;  4D3Q A;  1ZC0 A;  4R30 A;  4C13 A;  2Y1O A;  1UAG A;  1FGS A;  3BLU A;  1R6H A;  2ZN7 A;  3QCL A;  4ZI4 A;  4QUM A;  2H03 A;  3NRS A;  4OHI A;  5KA3 A;  4RKK A;  2MBC A;  2ZMM A;  5BUG A;  2F6Y A;  2CNH A;  1ONZ A;  1YWF A;  5A5F A;  3F9B A;  1Q6M A;  2QCJ A;  1BZJ A;  2Q47 A;  2I4H A;  1KAK A;  2CM3 A;  1I9S A;  2FJN A;  3ZM6 A;  3QCG A;  2VEY A;  1C84 A;  5K24 A;  4D3P A;  1I57 A;  2QBP A;  1LAR A;  2AM2 A;  2B4O A;  4GE5 A;  1YTS A;  1NWL A;  5MMZ B;  3AWG A;  3PYZ A;  3N2A A;  2PBN A;  3D1O A;  1PTU A;  1PTY A;  1NL9 A;  2CM2 A;  4PVG A;  3ZL8 A;  2BGE A;  4R0S A;  1KAV A;  4RI5 A;  3O4S A;  3D42 A;  4RH5 A;  1WRM A;  2HCM A;  3PS5 A;  2CNG A;  1OET A;  1LYV A;  1YN9 A;  4WU3 A;  1Q6P A;  3V0D A;  3ZM1 A;  5M43 A;  1C88 A;  2GC6 A;  3RGQ A;  2Y66 A;  2CM8 A;  2CNE A;  4BUC A;  1J4X A;  4QAH A;  3EB1 A;  1EEH A;  3EAX A;  5K9W A;  3ZV2 A;  1FPZ A;  2Y2F A;  5EHR A;  2JFF A;  1GWZ A;  1BZC A;  4J51 A;  5BZZ A;  1GQQ A;  4YR8 B;  2I6P A;  5KA2 A;  3S3F A;  1ZZW A;  3QCC A;  4PYH A;  2G6Z A; 
#chains in the Genus database with same CATH homology
 3CWE A;  1YGR A;  2HNP A;  2QDM A;  3QCN A;  1T4J A;  4BPC A;  4NWG A;  4NX8 A;  3V0E A;  3RZ2 A;  3D9C A;  1PA1 A;  2I6M A;  4B04 A;  4DGX A;  3QCB A;  2OC3 A;  2F6V A;  3QKP A;  1YTW A;  2QDC A;  5KAA A;  1NNY A;  1ECV A;  2J16 A;  3EU0 A;  2I3U A;  1U26 A;  2I75 A;  2OZ5 A;  5KAD A;  3ZM2 A;  2HY3 A;  2QBS A;  1D5R A;  2NV5 A;  1VHR A;  2J16 B;  5EHP A;  4OHD A;  2E0T A;  4HJQ A;  3GXG A;  2HC2 A;  1Q1M A;  2PT0 A;  1C87 A;  3B7O A;  3BRH A;  4NYH A;  3ZM0 A;  1NZ7 A;  2VEV A;  3AWF A;  2HB1 A;  2H04 A;  2OOQ A;  2NLK A;  1ONY A;  2I1Y A;  3S4O A;  1C85 A;  4WU2 A;  2OUD A;  5BX1 A;  1RPM A;  1L8G A;  1L8K A;  2NTA A;  4BJO A;  2VEX A;  1OES A;  5KA1 A;  2F71 A;  2WGP A;  3A5K A;  4QUN A;  1V3A A;  1M3G A;  2VEW A;  4ZN5 A;  4HRF A;  1YTN A;  5BZX A;  4RI4 A;  5KA8 A;  1YPT A;  4AZ1 A;  4YAA A;  2G59 A;  2I6O A;  1OHE A;  2PA5 A;  3QCJ A;  1G7G A;  2F6F A;  1PYN A;  4MBB A;  1OHC A;  5KA7 A;  5K23 A;  4R0T A;  2GP0 A;  1JLN A;  4GE2 A;  1YFO A;  2P4D A;  4D3R A;  4GFV A;  3QKQ A;  1XRI A;  1JF7 A;  2Y96 A;  3V0J A;  1OEV A;  3QCD A;  1NWE A;  1XM2 A;  1A5Y A;  4I8N A;  2A3K A;  2F6T A;  1LQF A;  3ZMQ A;  2CNF A;  5K9V A;  2C46 A;  5J8R A;  3MOW A;  2YDU A;  2I3R A;  2NT7 A;  2QCT A;  2H4G A;  3GXH A;  2F6Z A;  4H34 A;  2HVL A;  4GRZ A;  4QBW A;  2PQ5 A;  3V0G A;  3S3H A;  3BM8 A;  4TVV A;  5KA4 A;  2AZR A;  2R0B A;  1G1G A;  3H2X A;  3OMH A;  1ZCL A;  3QCE A;  2I6J A;  1MKP A;  2CFV A;  1X24 A;  1PTV A;  3QCK A;  2I4E A;  1G4W R;  2NZ6 A;  5GTJ A;  1XXV A;  2H4K A;  3OLR A;  2A8B A;  2VEU A;  2F70 A;  4Y2E A;  4OHE A;  5KA9 A;  3S3E A;  4QBE A;  3SR9 A;  2BZL A;  1RXD A;  3SME A;  3D1Q A;  4ICZ A;  5KAC A;  1FPR A;  4H1O A;  3AWE A;  4QAP A;  5KAB A;  2BV5 A;  3ZM3 A;  1Q6N A;  2J17 A;  2FJM A;  4OHH A;  2DXP A;  4Y14 A;  2I5X A;  4S0G A;  3V0I A;  3ZMP A;  3O5X A;  1Q6S A;  3S3K A;  1T48 A;  2BGD A;  3F41 A;  5AWX A;  4KYR A;  2F6W A;  1GFY A;  3I80 A;  3O4U A;  1PXH A;  3NME A;  1YGU A;  3QCI A;  3MMJ A;  2C7S A;  1PH0 A;  1BZH A;  4RDD A;  3BLT A;  4KI9 A;  2B4U A;  4WOH A;  3O3L A;  5KA0 A;  3U96 A;  4KYQ A;  3V0F A;  3N0A A;  2I4G A;  2BIJ A;  3V0H A;  2NT2 A;  2H4V A;  2Q05 A;  2QBR A;  2RF6 A;  1WAX A;  1G1H A;  1QXK A;  3EMU A;  1EEO A;  5IBM A;  2CMB A;  2CMC A;  3S4E A;  1T49 A;  2CJZ A;  1U25 A;  2JJD A;  1P15 A;  2PSZ A;  1I9T A;  2P6X A;  3M4U A;  1YZ4 A;  4JMJ A;  2B4S A;  4NWF A;  3QCF A;  3I7Z A;  1G1F A;  1G4U S;  1XXP A;  4Z6B A;  4ZRT A;  3O4T A;  4GRY A;  2HXP A;  3F81 A;  2HNQ A;  4GFU A;  1FQ1 A;  2SHP A;  2AHS A;  1U24 A;  4GS0 A;  1OEO X;  1OEU A;  2M3V A;  2F46 A;  3I36 A;  5I6V A;  2QBQ A;  4IKC A;  2B3O A;  1OEM X;  4GE6 A;  4JNB A;  2QDP A;  3EZZ A;  1PTT A;  2CNI A;  3QCM A;  1C83 A;  2IMG A;  2I42 A;  5K25 A;  2FH7 A;  4ERC A;  4JBC A;  1EEN A;  1XBO A;  2QEP A;  3D44 A;  1G7F A;  2B4P A;  1C86 A;  2B07 A;  4WTY A;  2B49 A;  2GWO A;  5LXQ B;  3CM3 A;  1QZ0 A;  3QCH A;  2I6I A;  3F9A A;  4GWF A;  1Q6J A;  1SUG A;  1OHD A;  3RGO A;  2GJT A;  1PA9 A;  2CM7 A;  1Q6T A;  4RH9 A;  1AAX A;  3D1H A;  2ESB A;  3F99 A;  2PI7 A;  5K22 A;  3A5J A;  4JMK A;  4HJP A;  3MOZ A;  3RO1 A;  3LJ8 A;  4OHL A;  1NO6 A;  4NND A;  2CMA A;  4RHG A;  5IBS A;  2HC1 A;  2H02 A;  1WCH A;  1ZCK A;  5HDE A;  4DGP A;  4D3Q A;  1ZC0 A;  4R30 A;  3BLU A;  1R6H A;  2ZN7 A;  3QCL A;  4ZI4 A;  4QUM A;  2H03 A;  4OHI A;  5KA3 A;  4RKK A;  2MBC A;  2ZMM A;  5BUG A;  2F6Y A;  2CNH A;  1ONZ A;  1YWF A;  3F9B A;  1Q6M A;  2QCJ A;  1BZJ A;  2Q47 A;  2I4H A;  1KAK A;  2CM3 A;  1I9S A;  2FJN A;  3QCG A;  2VEY A;  1C84 A;  5K24 A;  4D3P A;  1I57 A;  2QBP A;  1LAR A;  2B4O A;  4GE5 A;  1YTS A;  1NWL A;  5MMZ B;  3AWG A;  2PBN A;  3D1O A;  1PTU A;  1PTY A;  1NL9 A;  2CM2 A;  4PVG A;  2BGE A;  4R0S A;  1KAV A;  4RI5 A;  3O4S A;  3D42 A;  4RH5 A;  1WRM A;  2HCM A;  3PS5 A;  2CNG A;  1OET A;  1LYV A;  1YN9 A;  4WU3 A;  1Q6P A;  3V0D A;  3ZM1 A;  5M43 A;  1C88 A;  3RGQ A;  2CM8 A;  2CNE A;  1J4X A;  4QAH A;  3EB1 A;  3EAX A;  5K9W A;  3ZV2 A;  1FPZ A;  2Y2F A;  5EHR A;  1GWZ A;  1BZC A;  4J51 A;  5BZZ A;  4YR8 B;  2I6P A;  5KA2 A;  3S3F A;  1ZZW A;  3QCC A;  4PYH A;  2G6Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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