2BGEA

Structure-based design of protein tyrosine phosphatase-1b inhibitors
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
297
structure length
297
Chain Sequence
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Based Design of Protein Tyrosine Phosphatase-1B Inhibitors
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords PROTEIN-TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 1
total genus 108
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2004-12-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2bgeA00
2I3RA 2WGPA 2I6MA 1C88A 1J4XA 2I1YA 3BRHA 1KAVA 4TVVA 4NYHA 2PA5A 3BLTA 4BJOA 1PA1A 2J17A 1ECVA 1Q6NA 2R0BA 1AAXA 2F70A 1NWEA 1FPZA 2FJMA 3AWEA 3ZMQA 5K23A 5KA3A 2QBSA 1QXKA 3QKPA 5BX1A 1ZZWA 4Y14A 3U96A 1PTVA 5K22A 2F6FA 2GWOA 2OC3A 1BZHA 3D42A 2QEPA 3QCDA 3MMJA 1YTWA 4MBBA 2Q47A 1EENA 1Q6SA 5EHPA 3QCEA 3QKQA 4D3PA 3AWGA 4GRYA 4QAPA 1ONYA 1FQ1A 1V3AA 2HVLA 3QCJA 4ZRTA 1U25A 5K9VA 2CFVA 3QCBA 1D5RA 4HJPA 3V0EA 4QUMA 3S3FA 2J16B 1YTSA 3M4UA 1Q1MA 3MOWA 4H1OA 2F6ZA 3ZMPA 2HB1A 3F41A 1Q6MA 3A5JA 2CM2A 4QAHA 2AHSA 2I6PA 4QBWA 2HNQA 3QCCA 4NWGA 2BZLA 2NT2A 3I7ZA 2I6JA 5K25A 3RGOA 4RHGA 1YN9A 3GXGA 1VHRA 3N0AA 2PQ5A 2H4GA 3D1HA 1PA9A 2Y2FA 4GE6A 4QUNA 1XBOA 4JBCA 3F81A 5J8RA 5M43A 3AWFA 3S3KA 1QZ0A 1JLNA 3ZV2A 3O4UA 1WAXA 1NO6A 2CNFA 2CMAA 1C86A 2B4UA 2H02A 4ZN5A 4WOHA 3SMEA 1ZCLA 1NWLA 4ZI4A 2BGEA 2QDPA 1GFYA 1PXHA 4KYRA 2GP0A 4J51A 1OESA 1EEOA 4GFUA 2PSZA 3F99A 4R30A 1L8KA 2G6ZA 2NT7A 3V0HA 2C46A 4WTYA 5GTJA 2F46A 4B04A 3O3LA 2QDCA 3O4TA 3BLUA 2B3OA 1YWFA 2AZRA 5KA4A 1NL9A 1OEVA 2Y96A 4ICZA 2RF6A 3S4EA 1WCHA 2A8BA 4Y2EA 4DGXA 1A5YA 3V0DA 1KAKA 2CJZA 3D9CA 1XM2A 1OEUA 3EMUA 2FJNA 1BZCA 3V0GA 2B4OA 2BGDA 1Q6TA 1G4WR 5AWXA 1LARA 1ONZA 1C87A 2M3VA 1G4US 2I6OA 4OHDA 4R0TA 4RH9A 1XRIA 1MKPA 2E0TA 4YAAA 2Q05A 3QCHA 1YGRA 1L8GA 3OLRA 1WRMA 3RGQA 5K9WA 2CM8A 1FPRA 2GJTA 3QCFA 3EB1A 2PT0A 3GXHA 4GFVA 1X24A 1PH0A 2B4SA 3EU0A 5IBSA 3QCNA 3A5KA 3QCGA 1Q6PA 4WU2A 2I4EA 1T48A 2H04A 2YDUA 2H03A 2HNPA 3V0FA 2CNEA 2NZ6A 2QBPA 2VEUA 5IBMA 2C7SA 3H2XA 2I75A 3QCKA 2CMCA 3ZM0A 2NTAA 4D3RA 4KI9A 4PYHA 2VEVA 2CNHA 4KYQA 1PTTA 5KADA 1OHEA 3CWEA 1OEMX 1RXDA 2P4DA 1OHCA 1C85A 2ZN7A 5KABA 4I8NA 2DXPA 2FH7A 5BZXA 2QBRA 5MMZB 4D3QA 1G7FA 1R6HA 1C83A 2I42A 5KA7A 2NV5A 1G1FA 2SHPA 4RI4A 2VEWA 4PVGA 4OHHA 2PI7A 5LXQB 3B7OA 3I36A 1LQFA 2ZMMA 2F6WA 3SR9A 5KA2A 2QCJA 4HJQA 1ZC0A 1ZCKA 2VEXA 5BZZA 2QBQA 1YZ4A 4JMJA 2MBCA 1PYNA 3S4OA 2F6TA 2G59A 1C84A 4AZ1A 2QCTA 4OHLA 3CM3A 2HC1A 1T4JA 2OOQA 4OHEA 1YFOA 3QCLA 4GS0A 4HRFA 1RPMA 3LJ8A 3EAXA 4Z6BA 3QCIA 1OHDA 4RKKA 4BPCA 4QBEA 2F71A 5KA9A 1SUGA 4GWFA 2B07A 5HDEA 4GRZA 2QDMA 1I9TA 2CMBA 3MOZA 4IKCA 2VEYA 1XXVA 2P6XA 1PTUA 4RDDA 2CNGA 5EHRA 2BV5A 3RO1A 1I9SA 4JNBA 1PTYA 2HC2A 3F9AA 1P15A 1GWZA 3F9BA 1YPTA 2BIJA 3ZM3A 1NNYA 1LYVA 2IMGA 3I80A 3D1QA 1OEOX 1OETA 1G1GA 5I6VA 3BM8A 1YTNA 2J16A 2PBNA 1BZJA 4NX8A 1G7GA 3O5XA 4NWFA 4OHIA 4DGPA 1G1HA 2CM3A 3RZ2A 2F6VA 4RI5A 3NMEA 2A3KA 1XXPA 3OMHA 2OZ5A 4NNDA 1M3GA 5KA8A 2CM7A 2I4GA 2OUDA 4ERCA 2JJDA 4GE2A 1JF7A 1I57A 4WU3A 5K24A 2F6YA 3V0IA 3D1OA 2B49A 3EZZA 2H4KA 3S3EA 3ZM1A 1Q6JA 2H4VA 2ESBA 2HXPA 5KACA 2I6IA 3ZM2A 3PS5A 4GE5A 1U26A 2HCMA 3QCMA 3D44A 3O4SA 1T49A 2NLKA 3V0JA 4RH5A 5KA0A 5KAAA 5KA1A 4JMKA 5BUGA 2I3UA 4S0GA 4YR8B 1NZ7A 1YGUA 2I4HA 4R0SA 4H34A 2HY3A 2B4PA 2CNIA 3S3HA 2I5XA 1U24A
chains in the Genus database with same CATH superfamily
2I3RA 2WGPA 2I6MA 3ZM6A 1C88A 1J4XA 2I1YA 2VTEA 3BRHA 2UUPA 1KAVA 4TVVA 4NYHA 2PA5A 3BLTA 4BJOA 1PA1A 5A5EA 2J17A 1ECVA 1Q6NA 2R0BA 1AAXA 2F70A 1NWEA 1FPZA 2FJMA 3AWEA 3ZMQA 5K23A 5KA3A 2QBSA 1QXKA 3QKPA 5BX1A 1ZZWA 2XPCA 4Y14A 1PTVA 3U96A 5K22A 2F6FA 2GWOA 2OC3A 1BZHA 3D42A 2QEPA 2JFHA 3MMJA 3QCDA 1YTWA 2GC5A 4MBBA 4CVLA 2Q47A 1E8CA 1EENA 1Q6SA 5EHPA 3QCEA 3QKQA 4D3PA 3AWGA 4GRYA 4QAPA 1ONYA 1FGSA 4CVKA 1P3DA 1FQ1A 1V3AA 2HVLA 3QCJA 4ZRTA 2GC6A 1U25A 5K9VA 2CFVA 2VOSA 3QCBA 1D5RA 4HJPA 3V0EA 4QUMA 3S3FA 2J16B 1YTSA 3M4UA 1Q1MA 3MOWA 4H1OA 2F6ZA 1W78A 3ZMPA 2HB1A 3F41A 1Q6MA 3A5JA 2CM2A 4QAHA 3QCZA 2AHSA 2I6PA 4QBWA 2Y68A 2HNQA 3QCCA 4NWGA 2BZLA 2NT2A 3I7ZA 2I6JA 2UAGA 5K25A 2Y1OA 3RGOA 4RHGA 1YN9A 2WJPA 3GXGA 1VHRA 3N0AA 2PQ5A 4C12A 1J6UA 2H4GA 3D1HA 1PA9A 2Y2FA 4GE6A 4QUNA 1XBOA 4JBCA 3F81A 5J8RA 5M43A 1JBWA 3AWFA 3S3KA 1QZ0A 1JLNA 3ZV2A 3O4UA 1WAXA 1NO6A 3N2AA 2CNFA 2CMAA 1C86A 2B4UA 2H02A 4ZN5A 4WOHA 3SMEA 1ZCLA 1NWLA 4ZI4A 2BGEA 2QDPA 2VORA 1GFYA 1PXHA 4KYRA 2GP0A 4J51A 3MVNA 1OESA 1EEOA 4GFUA 2PSZA 3F99A 4R30A 1L8KA 2G6ZA 2NT7A 3V0HA 2C46A 4WTYA 5GTJA 2F46A 4B04A 4C13A 3O3LA 2QDCA 3O4TA 3BLUA 2B3OA 1YWFA 2AZRA 5KA4A 1NL9A 1OEVA 2Y96A 4ICZA 2RF6A 3S4EA 1WCHA 2A8BA 4Y2EA 4DGXA 2VTDA 1A5YA 3HN7A 3NRSA 3V0DA 1KAKA 2CJZA 1JBVA 2AM1A 3D9CA 1XM2A 1OEUA 3EMUA 2FJNA 1BZCA 3V0GA 2B4OA 2BGDA 1Q6TA 1G4WR 5AWXA 1ONZA 1LARA 1C87A 2M3VA 1G4US 2I6OA 4OHDA 4R0TA 4RH9A 1XRIA 1MKPA 2E0TA 4YAAA 2Q05A 3QCHA 1YGRA 1L8GA 3OLRA 1WRMA 3RGQA 5K9WA 2CM8A 1FPRA 2GJTA 3QCFA 3EB1A 4BUBA 2PT0A 3GXHA 4GFVA 1X24A 1EEHA 1PH0A 2F00A 2Y67A 2B4SA 3EU0A 5IBSA 3QCNA 3A5KA 3QCGA 1Q6PA 4WU2A 2I4EA 1T48A 2H04A 2YDUA 2H03A 2HNPA 3V0FA 2CNEA 2NZ6A 2QBPA 2VEUA 5IBMA 2C7SA 3H2XA 1E0DA 2I75A 2CMCA 3QCKA 3ZM0A 2NTAA 4D3RA 4KI9A 4PYHA 2VEVA 2CNHA 4KYQA 4CVMA 1PTTA 5KADA 4UAGA 1OHEA 3CWEA 1OEMX 1RXDA 2P4DA 1OHCA 1C85A 2ZN7A 5KABA 4I8NA 2DXPA 1GQYA 2FH7A 5BZXA 2QBRA 5MMZB 4D3QA 1G7FA 1R6HA 1C83A 2I42A 5KA7A 2NV5A 1G1FA 2SHPA 4RI4A 2VEWA 4PVGA 4OHHA 2JFFA 4QF5A 5A5FA 2PI7A 2AM2A 3ZL8A 5LXQB 3B7OA 3I36A 1LQFA 2ZMMA 2F6WA 3SR9A 5KA2A 1O5ZA 2QCJA 4HJQA 1ZC0A 1ZCKA 2VEXA 5BZZA 2QBQA 1YZ4A 2GCAA 4JMJA 2MBCA 1PYNA 3S4OA 2F6TA 2G59A 1C84A 4AZ1A 2QCTA 1UAGA 4OHLA 3CM3A 2HC1A 1T4JA 2OOQA 3PYZA 4OHEA 1GG4A 1YFOA 3QCLA 4GS0A 3LK7A 4HRFA 4ZIYA 1RPMA 3LJ8A 3EAXA 4Z6BA 3QCIA 1OHDA 2Y66A 4RKKA 4BPCA 4QBEA 2F71A 5KA9A 3UAGA 1SUGA 4GWFA 2B07A 5HDEA 4GRZA 2QDMA 1I9TA 2CMBA 3MOZA 4IKCA 2VEYA 1XXVA 2P6XA 1PTUA 4RDDA 2CNGA 5EHRA 2BV5A 3RO1A 1I9SA 4JNBA 1PTYA 2HC2A 3F9AA 1P31A 1P15A 1GWZA 3F9BA 1YPTA 2BIJA 3ZM3A 1NNYA 1LYVA 2IMGA 3I80A 3D1QA 1OEOX 1OETA 1G1GA 5I6VA 3BM8A 1YTNA 2J16A 2PBNA 1BZJA 2GCBA 4NX8A 1G7GA 3O5XA 4NWFA 4OHIA 2JFGA 4DGPA 1G1HA 2CM3A 3RZ2A 2F6VA 4RI5A 3NMEA 2A3KA 1XXPA 3OMHA 2OZ5A 4NNDA 1M3GA 5KA8A 2CM7A 2I4GA 2OUDA 4ERCA 2JJDA 1GQQA 4GE2A 1JF7A 2UUOA 1I57A 4WU3A 5K24A 2F6YA 3ZM5A 3V0IA 3D1OA 2B49A 3EZZA 2H4KA 3S3EA 3ZM1A 1Q6JA 2H4VA 2ESBA 2HXPA 2XJAA 5KACA 2I6IA 3ZM2A 3PS5A 4QDIA 4GE5A 1U26A 2HCMA 3QCMA 3D44A 3O4SA 1T49A 2NLKA 3V0JA 4RH5A 5KA0A 5KAAA 5KA1A 4JMKA 5BUGA 2I3UA 4S0GA 4YR8B 1NZ7A 1YGUA 2I4HA 4HV4A 4R0SA 4H34A 2HY3A 2B4PA 1W7KA 2CNIA 3S3HA 2WTZA 2I5XA 2X5OA 4BUCA 1U24A
chains in the Genus database with same CATH topology
2I3RA 2WGPA 2I6MA 1C88A 1J4XA 2I1YA 3BRHA 1KAVA 4TVVA 4NYHA 2PA5A 3BLTA 4BJOA 1PA1A 2J17A 1ECVA 1Q6NA 2R0BA 1AAXA 2F70A 1NWEA 1FPZA 2FJMA 3AWEA 3ZMQA 5K23A 5KA3A 2QBSA 1QXKA 3QKPA 5BX1A 1ZZWA 4Y14A 3U96A 1PTVA 5K22A 2F6FA 2GWOA 2OC3A 1BZHA 3D42A 2QEPA 3QCDA 3MMJA 1YTWA 4MBBA 2Q47A 1EENA 1Q6SA 5EHPA 3QCEA 3QKQA 4D3PA 3AWGA 4GRYA 4QAPA 1ONYA 1FQ1A 1V3AA 2HVLA 3QCJA 4ZRTA 1U25A 5K9VA 2CFVA 3QCBA 1D5RA 4HJPA 3V0EA 4QUMA 3S3FA 2J16B 1YTSA 3M4UA 1Q1MA 3MOWA 4H1OA 2F6ZA 3ZMPA 2HB1A 3F41A 1Q6MA 3A5JA 2CM2A 4QAHA 2AHSA 2I6PA 4QBWA 2HNQA 3QCCA 4NWGA 2BZLA 2NT2A 3I7ZA 2I6JA 5K25A 3RGOA 4RHGA 1YN9A 3GXGA 1VHRA 3N0AA 2PQ5A 2H4GA 3D1HA 1PA9A 2Y2FA 4GE6A 4QUNA 1XBOA 4JBCA 3F81A 5J8RA 5M43A 3AWFA 3S3KA 1QZ0A 1JLNA 3ZV2A 3O4UA 1WAXA 1NO6A 2CNFA 2CMAA 1C86A 2B4UA 2H02A 4ZN5A 4WOHA 3SMEA 1ZCLA 1NWLA 4ZI4A 2BGEA 2QDPA 1GFYA 1PXHA 4KYRA 2GP0A 4J51A 1OESA 1EEOA 4GFUA 2PSZA 3F99A 4R30A 1L8KA 2G6ZA 2NT7A 3V0HA 2C46A 4WTYA 5GTJA 2F46A 4B04A 3O3LA 2QDCA 3O4TA 3BLUA 2B3OA 1YWFA 2AZRA 5KA4A 1NL9A 1OEVA 2Y96A 4ICZA 2RF6A 3S4EA 1WCHA 2A8BA 4Y2EA 4DGXA 1A5YA 3V0DA 1KAKA 2CJZA 3D9CA 1XM2A 1OEUA 3EMUA 2FJNA 1BZCA 3V0GA 2B4OA 2BGDA 1Q6TA 1G4WR 5AWXA 1LARA 1ONZA 1C87A 2M3VA 1G4US 2I6OA 4OHDA 4R0TA 4RH9A 1XRIA 1MKPA 2E0TA 4YAAA 2Q05A 3QCHA 1YGRA 1L8GA 3OLRA 1WRMA 3RGQA 5K9WA 2CM8A 1FPRA 2GJTA 3QCFA 3EB1A 2PT0A 3GXHA 4GFVA 1X24A 1PH0A 2B4SA 3EU0A 5IBSA 3QCNA 3A5KA 3QCGA 1Q6PA 4WU2A 2I4EA 1T48A 2H04A 2YDUA 2H03A 2HNPA 3V0FA 2CNEA 2NZ6A 2QBPA 2VEUA 5IBMA 2C7SA 3H2XA 2I75A 3QCKA 2CMCA 3ZM0A 2NTAA 4D3RA 4KI9A 4PYHA 2VEVA 2CNHA 4KYQA 1PTTA 5KADA 1OHEA 3CWEA 1OEMX 1RXDA 2P4DA 1OHCA 1C85A 2ZN7A 5KABA 4I8NA 2DXPA 2FH7A 5BZXA 2QBRA 5MMZB 4D3QA 1G7FA 1R6HA 1C83A 2I42A 5KA7A 2NV5A 1G1FA 2SHPA 4RI4A 2VEWA 4PVGA 4OHHA 2PI7A 5LXQB 3B7OA 3I36A 1LQFA 2ZMMA 2F6WA 3SR9A 5KA2A 2QCJA 4HJQA 1ZC0A 1ZCKA 2VEXA 5BZZA 2QBQA 1YZ4A 4JMJA 2MBCA 1PYNA 3S4OA 2F6TA 2G59A 1C84A 4AZ1A 2QCTA 4OHLA 3CM3A 2HC1A 1T4JA 2OOQA 4OHEA 1YFOA 3QCLA 4GS0A 4HRFA 1RPMA 3LJ8A 3EAXA 4Z6BA 3QCIA 1OHDA 4RKKA 4BPCA 4QBEA 2F71A 5KA9A 1SUGA 4GWFA 2B07A 5HDEA 4GRZA 2QDMA 1I9TA 2CMBA 3MOZA 4IKCA 2VEYA 1XXVA 2P6XA 1PTUA 4RDDA 2CNGA 5EHRA 2BV5A 3RO1A 1I9SA 4JNBA 1PTYA 2HC2A 3F9AA 1P15A 1GWZA 3F9BA 1YPTA 2BIJA 3ZM3A 1NNYA 1LYVA 2IMGA 3I80A 3D1QA 1OEOX 1OETA 1G1GA 5I6VA 3BM8A 1YTNA 2J16A 2PBNA 1BZJA 4NX8A 1G7GA 3O5XA 4NWFA 4OHIA 4DGPA 1G1HA 2CM3A 3RZ2A 2F6VA 4RI5A 3NMEA 2A3KA 1XXPA 3OMHA 2OZ5A 4NNDA 1M3GA 5KA8A 2CM7A 2I4GA 2OUDA 4ERCA 2JJDA 4GE2A 1JF7A 1I57A 4WU3A 5K24A 2F6YA 3V0IA 3D1OA 2B49A 3EZZA 2H4KA 3S3EA 3ZM1A 1Q6JA 2H4VA 2ESBA 2HXPA 5KACA 2I6IA 3ZM2A 3PS5A 4GE5A 1U26A 2HCMA 3QCMA 3D44A 3O4SA 1T49A 2NLKA 3V0JA 4RH5A 5KA0A 5KAAA 5KA1A 4JMKA 5BUGA 2I3UA 4S0GA 4YR8B 1NZ7A 1YGUA 2I4HA 4R0SA 4H34A 2HY3A 2B4PA 2CNIA 3S3HA 2I5XA 1U24A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I3R A;  2WGP A;  2I6M A;  1C88 A;  1J4X A;  2I1Y A;  3BRH A;  1KAV A;  4TVV A;  4NYH A;  2PA5 A;  3BLT A;  4BJO A;  1PA1 A;  2J17 A;  1ECV A;  1Q6N A;  2R0B A;  1AAX A;  2F70 A;  1NWE A;  1FPZ A;  2FJM A;  3AWE A;  3ZMQ A;  5K23 A;  5KA3 A;  2QBS A;  1QXK A;  3QKP A;  5BX1 A;  1ZZW A;  4Y14 A;  3U96 A;  1PTV A;  5K22 A;  2F6F A;  2GWO A;  2OC3 A;  1BZH A;  3D42 A;  2QEP A;  3QCD A;  3MMJ A;  1YTW A;  4MBB A;  2Q47 A;  1EEN A;  1Q6S A;  5EHP A;  3QCE A;  3QKQ A;  4D3P A;  3AWG A;  4GRY A;  4QAP A;  1ONY A;  1FQ1 A;  1V3A A;  2HVL A;  3QCJ A;  4ZRT A;  1U25 A;  5K9V A;  2CFV A;  3QCB A;  1D5R A;  4HJP A;  3V0E A;  4QUM A;  3S3F A;  2J16 B;  1YTS A;  3M4U A;  1Q1M A;  3MOW A;  4H1O A;  2F6Z A;  3ZMP A;  2HB1 A;  3F41 A;  1Q6M A;  3A5J A;  2CM2 A;  4QAH A;  2AHS A;  2I6P A;  4QBW A;  2HNQ A;  3QCC A;  4NWG A;  2BZL A;  2NT2 A;  3I7Z A;  2I6J A;  5K25 A;  3RGO A;  4RHG A;  1YN9 A;  3GXG A;  1VHR A;  3N0A A;  2PQ5 A;  2H4G A;  3D1H A;  1PA9 A;  2Y2F A;  4GE6 A;  4QUN A;  1XBO A;  4JBC A;  3F81 A;  5J8R A;  5M43 A;  3AWF A;  3S3K A;  1QZ0 A;  1JLN A;  3ZV2 A;  3O4U A;  1WAX A;  1NO6 A;  2CNF A;  2CMA A;  1C86 A;  2B4U A;  2H02 A;  4ZN5 A;  4WOH A;  3SME A;  1ZCL A;  1NWL A;  4ZI4 A;  2BGE A;  2QDP A;  1GFY A;  1PXH A;  4KYR A;  2GP0 A;  4J51 A;  1OES A;  1EEO A;  4GFU A;  2PSZ A;  3F99 A;  4R30 A;  1L8K A;  2G6Z A;  2NT7 A;  3V0H A;  2C46 A;  4WTY A;  5GTJ A;  2F46 A;  4B04 A;  3O3L A;  2QDC A;  3O4T A;  3BLU A;  2B3O A;  1YWF A;  2AZR A;  5KA4 A;  1NL9 A;  1OEV A;  2Y96 A;  4ICZ A;  2RF6 A;  3S4E A;  1WCH A;  2A8B A;  4Y2E A;  4DGX A;  1A5Y A;  3V0D A;  1KAK A;  2CJZ A;  3D9C A;  1XM2 A;  1OEU A;  3EMU A;  2FJN A;  1BZC A;  3V0G A;  2B4O A;  2BGD A;  1Q6T A;  1G4W R;  5AWX A;  1LAR A;  1ONZ A;  1C87 A;  2M3V A;  1G4U S;  2I6O A;  4OHD A;  4R0T A;  4RH9 A;  1XRI A;  1MKP A;  2E0T A;  4YAA A;  2Q05 A;  3QCH A;  1YGR A;  1L8G A;  3OLR A;  1WRM A;  3RGQ A;  5K9W A;  2CM8 A;  1FPR A;  2GJT A;  3QCF A;  3EB1 A;  2PT0 A;  3GXH A;  4GFV A;  1X24 A;  1PH0 A;  2B4S A;  3EU0 A;  5IBS A;  3QCN A;  3A5K A;  3QCG A;  1Q6P A;  4WU2 A;  2I4E A;  1T48 A;  2H04 A;  2YDU A;  2H03 A;  2HNP A;  3V0F A;  2CNE A;  2NZ6 A;  2QBP A;  2VEU A;  5IBM A;  2C7S A;  3H2X A;  2I75 A;  3QCK A;  2CMC A;  3ZM0 A;  2NTA A;  4D3R A;  4KI9 A;  4PYH A;  2VEV A;  2CNH A;  4KYQ A;  1PTT A;  5KAD A;  1OHE A;  3CWE A;  1OEM X;  1RXD A;  2P4D A;  1OHC A;  1C85 A;  2ZN7 A;  5KAB A;  4I8N A;  2DXP A;  2FH7 A;  5BZX A;  2QBR A;  5MMZ B;  4D3Q A;  1G7F A;  1R6H A;  1C83 A;  2I42 A;  5KA7 A;  2NV5 A;  1G1F A;  2SHP A;  4RI4 A;  2VEW A;  4PVG A;  4OHH A;  2PI7 A;  5LXQ B;  3B7O A;  3I36 A;  1LQF A;  2ZMM A;  2F6W A;  3SR9 A;  5KA2 A;  2QCJ A;  4HJQ A;  1ZC0 A;  1ZCK A;  2VEX A;  5BZZ A;  2QBQ A;  1YZ4 A;  4JMJ A;  2MBC A;  1PYN A;  3S4O A;  2F6T A;  2G59 A;  1C84 A;  4AZ1 A;  2QCT A;  4OHL A;  3CM3 A;  2HC1 A;  1T4J A;  2OOQ A;  4OHE A;  1YFO A;  3QCL A;  4GS0 A;  4HRF A;  1RPM A;  3LJ8 A;  3EAX A;  4Z6B A;  3QCI A;  1OHD A;  4RKK A;  4BPC A;  4QBE A;  2F71 A;  5KA9 A;  1SUG A;  4GWF A;  2B07 A;  5HDE A;  4GRZ A;  2QDM A;  1I9T A;  2CMB A;  3MOZ A;  4IKC A;  2VEY A;  1XXV A;  2P6X A;  1PTU A;  4RDD A;  2CNG A;  5EHR A;  2BV5 A;  3RO1 A;  1I9S A;  4JNB A;  1PTY A;  2HC2 A;  3F9A A;  1P15 A;  1GWZ A;  3F9B A;  1YPT A;  2BIJ A;  3ZM3 A;  1NNY A;  1LYV A;  2IMG A;  3I80 A;  3D1Q A;  1OEO X;  1OET A;  1G1G A;  5I6V A;  3BM8 A;  1YTN A;  2J16 A;  2PBN A;  1BZJ A;  4NX8 A;  1G7G A;  3O5X A;  4NWF A;  4OHI A;  4DGP A;  1G1H A;  2CM3 A;  3RZ2 A;  2F6V A;  4RI5 A;  3NME A;  2A3K A;  1XXP A;  3OMH A;  2OZ5 A;  4NND A;  1M3G A;  5KA8 A;  2CM7 A;  2I4G A;  2OUD A;  4ERC A;  2JJD A;  4GE2 A;  1JF7 A;  1I57 A;  4WU3 A;  5K24 A;  2F6Y A;  3V0I A;  3D1O A;  2B49 A;  3EZZ A;  2H4K A;  3S3E A;  3ZM1 A;  1Q6J A;  2H4V A;  2ESB A;  2HXP A;  5KAC A;  2I6I A;  3ZM2 A;  3PS5 A;  4GE5 A;  1U26 A;  2HCM A;  3QCM A;  3D44 A;  3O4S A;  1T49 A;  2NLK A;  3V0J A;  4RH5 A;  5KA0 A;  5KAA A;  5KA1 A;  4JMK A;  5BUG A;  2I3U A;  4S0G A;  4YR8 B;  1NZ7 A;  1YGU A;  2I4H A;  4R0S A;  4H34 A;  2HY3 A;  2B4P A;  2CNI A;  3S3H A;  2I5X A;  1U24 A; 
#chains in the Genus database with same CATH topology
 2I3R A;  2WGP A;  2I6M A;  3ZM6 A;  1C88 A;  1J4X A;  2I1Y A;  2VTE A;  3BRH A;  2UUP A;  1KAV A;  4TVV A;  4NYH A;  2PA5 A;  3BLT A;  4BJO A;  1PA1 A;  5A5E A;  2J17 A;  1ECV A;  1Q6N A;  2R0B A;  1AAX A;  2F70 A;  1NWE A;  1FPZ A;  2FJM A;  3AWE A;  3ZMQ A;  5K23 A;  5KA3 A;  2QBS A;  1QXK A;  3QKP A;  5BX1 A;  1ZZW A;  2XPC A;  4Y14 A;  1PTV A;  3U96 A;  5K22 A;  2F6F A;  2GWO A;  2OC3 A;  1BZH A;  3D42 A;  2QEP A;  2JFH A;  3MMJ A;  3QCD A;  1YTW A;  2GC5 A;  4MBB A;  4CVL A;  2Q47 A;  1E8C A;  1EEN A;  1Q6S A;  5EHP A;  3QCE A;  3QKQ A;  4D3P A;  3AWG A;  4GRY A;  4QAP A;  1ONY A;  1FGS A;  4CVK A;  1P3D A;  1FQ1 A;  1V3A A;  2HVL A;  3QCJ A;  4ZRT A;  2GC6 A;  1U25 A;  5K9V A;  2CFV A;  2VOS A;  3QCB A;  1D5R A;  4HJP A;  3V0E A;  4QUM A;  3S3F A;  2J16 B;  1YTS A;  3M4U A;  1Q1M A;  3MOW A;  4H1O A;  2F6Z A;  1W78 A;  3ZMP A;  2HB1 A;  3F41 A;  1Q6M A;  3A5J A;  2CM2 A;  4QAH A;  3QCZ A;  2AHS A;  2I6P A;  4QBW A;  2Y68 A;  2HNQ A;  3QCC A;  4NWG A;  2BZL A;  2NT2 A;  3I7Z A;  2I6J A;  2UAG A;  5K25 A;  2Y1O A;  3RGO A;  4RHG A;  1YN9 A;  2WJP A;  3GXG A;  1VHR A;  3N0A A;  2PQ5 A;  4C12 A;  1J6U A;  2H4G A;  3D1H A;  1PA9 A;  2Y2F A;  4GE6 A;  4QUN A;  1XBO A;  4JBC A;  3F81 A;  5J8R A;  5M43 A;  1JBW A;  3AWF A;  3S3K A;  1QZ0 A;  1JLN A;  3ZV2 A;  3O4U A;  1WAX A;  1NO6 A;  3N2A A;  2CNF A;  2CMA A;  1C86 A;  2B4U A;  2H02 A;  4ZN5 A;  4WOH A;  3SME A;  1ZCL A;  1NWL A;  4ZI4 A;  2BGE A;  2QDP A;  2VOR A;  1GFY A;  1PXH A;  4KYR A;  2GP0 A;  4J51 A;  3MVN A;  1OES A;  1EEO A;  4GFU A;  2PSZ A;  3F99 A;  4R30 A;  1L8K A;  2G6Z A;  2NT7 A;  3V0H A;  2C46 A;  4WTY A;  5GTJ A;  2F46 A;  4B04 A;  4C13 A;  3O3L A;  2QDC A;  3O4T A;  3BLU A;  2B3O A;  1YWF A;  2AZR A;  5KA4 A;  1NL9 A;  1OEV A;  2Y96 A;  4ICZ A;  2RF6 A;  3S4E A;  1WCH A;  2A8B A;  4Y2E A;  4DGX A;  2VTD A;  1A5Y A;  3HN7 A;  3NRS A;  3V0D A;  1KAK A;  2CJZ A;  1JBV A;  2AM1 A;  3D9C A;  1XM2 A;  1OEU A;  3EMU A;  2FJN A;  1BZC A;  3V0G A;  2B4O A;  2BGD A;  1Q6T A;  1G4W R;  5AWX A;  1ONZ A;  1LAR A;  1C87 A;  2M3V A;  1G4U S;  2I6O A;  4OHD A;  4R0T A;  4RH9 A;  1XRI A;  1MKP A;  2E0T A;  4YAA A;  2Q05 A;  3QCH A;  1YGR A;  1L8G A;  3OLR A;  1WRM A;  3RGQ A;  5K9W A;  2CM8 A;  1FPR A;  2GJT A;  3QCF A;  3EB1 A;  4BUB A;  2PT0 A;  3GXH A;  4GFV A;  1X24 A;  1EEH A;  1PH0 A;  2F00 A;  2Y67 A;  2B4S A;  3EU0 A;  5IBS A;  3QCN A;  3A5K A;  3QCG A;  1Q6P A;  4WU2 A;  2I4E A;  1T48 A;  2H04 A;  2YDU A;  2H03 A;  2HNP A;  3V0F A;  2CNE A;  2NZ6 A;  2QBP A;  2VEU A;  5IBM A;  2C7S A;  3H2X A;  1E0D A;  2I75 A;  2CMC A;  3QCK A;  3ZM0 A;  2NTA A;  4D3R A;  4KI9 A;  4PYH A;  2VEV A;  2CNH A;  4KYQ A;  4CVM A;  1PTT A;  5KAD A;  4UAG A;  1OHE A;  3CWE A;  1OEM X;  1RXD A;  2P4D A;  1OHC A;  1C85 A;  2ZN7 A;  5KAB A;  4I8N A;  2DXP A;  1GQY A;  2FH7 A;  5BZX A;  2QBR A;  5MMZ B;  4D3Q A;  1G7F A;  1R6H A;  1C83 A;  2I42 A;  5KA7 A;  2NV5 A;  1G1F A;  2SHP A;  4RI4 A;  2VEW A;  4PVG A;  4OHH A;  2JFF A;  4QF5 A;  5A5F A;  2PI7 A;  2AM2 A;  3ZL8 A;  5LXQ B;  3B7O A;  3I36 A;  1LQF A;  2ZMM A;  2F6W A;  3SR9 A;  5KA2 A;  1O5Z A;  2QCJ A;  4HJQ A;  1ZC0 A;  1ZCK A;  2VEX A;  5BZZ A;  2QBQ A;  1YZ4 A;  2GCA A;  4JMJ A;  2MBC A;  1PYN A;  3S4O A;  2F6T A;  2G59 A;  1C84 A;  4AZ1 A;  2QCT A;  1UAG A;  4OHL A;  3CM3 A;  2HC1 A;  1T4J A;  2OOQ A;  3PYZ A;  4OHE A;  1GG4 A;  1YFO A;  3QCL A;  4GS0 A;  3LK7 A;  4HRF A;  4ZIY A;  1RPM A;  3LJ8 A;  3EAX A;  4Z6B A;  3QCI A;  1OHD A;  2Y66 A;  4RKK A;  4BPC A;  4QBE A;  2F71 A;  5KA9 A;  3UAG A;  1SUG A;  4GWF A;  2B07 A;  5HDE A;  4GRZ A;  2QDM A;  1I9T A;  2CMB A;  3MOZ A;  4IKC A;  2VEY A;  1XXV A;  2P6X A;  1PTU A;  4RDD A;  2CNG A;  5EHR A;  2BV5 A;  3RO1 A;  1I9S A;  4JNB A;  1PTY A;  2HC2 A;  3F9A A;  1P31 A;  1P15 A;  1GWZ A;  3F9B A;  1YPT A;  2BIJ A;  3ZM3 A;  1NNY A;  1LYV A;  2IMG A;  3I80 A;  3D1Q A;  1OEO X;  1OET A;  1G1G A;  5I6V A;  3BM8 A;  1YTN A;  2J16 A;  2PBN A;  1BZJ A;  2GCB A;  4NX8 A;  1G7G A;  3O5X A;  4NWF A;  4OHI A;  2JFG A;  4DGP A;  1G1H A;  2CM3 A;  3RZ2 A;  2F6V A;  4RI5 A;  3NME A;  2A3K A;  1XXP A;  3OMH A;  2OZ5 A;  4NND A;  1M3G A;  5KA8 A;  2CM7 A;  2I4G A;  2OUD A;  4ERC A;  2JJD A;  1GQQ A;  4GE2 A;  1JF7 A;  2UUO A;  1I57 A;  4WU3 A;  5K24 A;  2F6Y A;  3ZM5 A;  3V0I A;  3D1O A;  2B49 A;  3EZZ A;  2H4K A;  3S3E A;  3ZM1 A;  1Q6J A;  2H4V A;  2ESB A;  2HXP A;  2XJA A;  5KAC A;  2I6I A;  3ZM2 A;  3PS5 A;  4QDI A;  4GE5 A;  1U26 A;  2HCM A;  3QCM A;  3D44 A;  3O4S A;  1T49 A;  2NLK A;  3V0J A;  4RH5 A;  5KA0 A;  5KAA A;  5KA1 A;  4JMK A;  5BUG A;  2I3U A;  4S0G A;  4YR8 B;  1NZ7 A;  1YGU A;  2I4H A;  4HV4 A;  4R0S A;  4H34 A;  2HY3 A;  2B4P A;  1W7K A;  2CNI A;  3S3H A;  2WTZ A;  2I5X A;  2X5O A;  4BUC A;  1U24 A; 
#chains in the Genus database with same CATH homology
 2I3R A;  2WGP A;  2I6M A;  1C88 A;  1J4X A;  2I1Y A;  3BRH A;  1KAV A;  4TVV A;  4NYH A;  2PA5 A;  3BLT A;  4BJO A;  1PA1 A;  2J17 A;  1ECV A;  1Q6N A;  2R0B A;  1AAX A;  2F70 A;  1NWE A;  1FPZ A;  2FJM A;  3AWE A;  3ZMQ A;  5K23 A;  5KA3 A;  2QBS A;  1QXK A;  3QKP A;  5BX1 A;  1ZZW A;  4Y14 A;  3U96 A;  1PTV A;  5K22 A;  2F6F A;  2GWO A;  2OC3 A;  1BZH A;  3D42 A;  2QEP A;  3QCD A;  3MMJ A;  1YTW A;  4MBB A;  2Q47 A;  1EEN A;  1Q6S A;  5EHP A;  3QCE A;  3QKQ A;  4D3P A;  3AWG A;  4GRY A;  4QAP A;  1ONY A;  1FQ1 A;  1V3A A;  2HVL A;  3QCJ A;  4ZRT A;  1U25 A;  5K9V A;  2CFV A;  3QCB A;  1D5R A;  4HJP A;  3V0E A;  4QUM A;  3S3F A;  2J16 B;  1YTS A;  3M4U A;  1Q1M A;  3MOW A;  4H1O A;  2F6Z A;  3ZMP A;  2HB1 A;  3F41 A;  1Q6M A;  3A5J A;  2CM2 A;  4QAH A;  2AHS A;  2I6P A;  4QBW A;  2HNQ A;  3QCC A;  4NWG A;  2BZL A;  2NT2 A;  3I7Z A;  2I6J A;  5K25 A;  3RGO A;  4RHG A;  1YN9 A;  3GXG A;  1VHR A;  3N0A A;  2PQ5 A;  2H4G A;  3D1H A;  1PA9 A;  2Y2F A;  4GE6 A;  4QUN A;  1XBO A;  4JBC A;  3F81 A;  5J8R A;  5M43 A;  3AWF A;  3S3K A;  1QZ0 A;  1JLN A;  3ZV2 A;  3O4U A;  1WAX A;  1NO6 A;  2CNF A;  2CMA A;  1C86 A;  2B4U A;  2H02 A;  4ZN5 A;  4WOH A;  3SME A;  1ZCL A;  1NWL A;  4ZI4 A;  2BGE A;  2QDP A;  1GFY A;  1PXH A;  4KYR A;  2GP0 A;  4J51 A;  1OES A;  1EEO A;  4GFU A;  2PSZ A;  3F99 A;  4R30 A;  1L8K A;  2G6Z A;  2NT7 A;  3V0H A;  2C46 A;  4WTY A;  5GTJ A;  2F46 A;  4B04 A;  3O3L A;  2QDC A;  3O4T A;  3BLU A;  2B3O A;  1YWF A;  2AZR A;  5KA4 A;  1NL9 A;  1OEV A;  2Y96 A;  4ICZ A;  2RF6 A;  3S4E A;  1WCH A;  2A8B A;  4Y2E A;  4DGX A;  1A5Y A;  3V0D A;  1KAK A;  2CJZ A;  3D9C A;  1XM2 A;  1OEU A;  3EMU A;  2FJN A;  1BZC A;  3V0G A;  2B4O A;  2BGD A;  1Q6T A;  1G4W R;  5AWX A;  1LAR A;  1ONZ A;  1C87 A;  2M3V A;  1G4U S;  2I6O A;  4OHD A;  4R0T A;  4RH9 A;  1XRI A;  1MKP A;  2E0T A;  4YAA A;  2Q05 A;  3QCH A;  1YGR A;  1L8G A;  3OLR A;  1WRM A;  3RGQ A;  5K9W A;  2CM8 A;  1FPR A;  2GJT A;  3QCF A;  3EB1 A;  2PT0 A;  3GXH A;  4GFV A;  1X24 A;  1PH0 A;  2B4S A;  3EU0 A;  5IBS A;  3QCN A;  3A5K A;  3QCG A;  1Q6P A;  4WU2 A;  2I4E A;  1T48 A;  2H04 A;  2YDU A;  2H03 A;  2HNP A;  3V0F A;  2CNE A;  2NZ6 A;  2QBP A;  2VEU A;  5IBM A;  2C7S A;  3H2X A;  2I75 A;  3QCK A;  2CMC A;  3ZM0 A;  2NTA A;  4D3R A;  4KI9 A;  4PYH A;  2VEV A;  2CNH A;  4KYQ A;  1PTT A;  5KAD A;  1OHE A;  3CWE A;  1OEM X;  1RXD A;  2P4D A;  1OHC A;  1C85 A;  2ZN7 A;  5KAB A;  4I8N A;  2DXP A;  2FH7 A;  5BZX A;  2QBR A;  5MMZ B;  4D3Q A;  1G7F A;  1R6H A;  1C83 A;  2I42 A;  5KA7 A;  2NV5 A;  1G1F A;  2SHP A;  4RI4 A;  2VEW A;  4PVG A;  4OHH A;  2PI7 A;  5LXQ B;  3B7O A;  3I36 A;  1LQF A;  2ZMM A;  2F6W A;  3SR9 A;  5KA2 A;  2QCJ A;  4HJQ A;  1ZC0 A;  1ZCK A;  2VEX A;  5BZZ A;  2QBQ A;  1YZ4 A;  4JMJ A;  2MBC A;  1PYN A;  3S4O A;  2F6T A;  2G59 A;  1C84 A;  4AZ1 A;  2QCT A;  4OHL A;  3CM3 A;  2HC1 A;  1T4J A;  2OOQ A;  4OHE A;  1YFO A;  3QCL A;  4GS0 A;  4HRF A;  1RPM A;  3LJ8 A;  3EAX A;  4Z6B A;  3QCI A;  1OHD A;  4RKK A;  4BPC A;  4QBE A;  2F71 A;  5KA9 A;  1SUG A;  4GWF A;  2B07 A;  5HDE A;  4GRZ A;  2QDM A;  1I9T A;  2CMB A;  3MOZ A;  4IKC A;  2VEY A;  1XXV A;  2P6X A;  1PTU A;  4RDD A;  2CNG A;  5EHR A;  2BV5 A;  3RO1 A;  1I9S A;  4JNB A;  1PTY A;  2HC2 A;  3F9A A;  1P15 A;  1GWZ A;  3F9B A;  1YPT A;  2BIJ A;  3ZM3 A;  1NNY A;  1LYV A;  2IMG A;  3I80 A;  3D1Q A;  1OEO X;  1OET A;  1G1G A;  5I6V A;  3BM8 A;  1YTN A;  2J16 A;  2PBN A;  1BZJ A;  4NX8 A;  1G7G A;  3O5X A;  4NWF A;  4OHI A;  4DGP A;  1G1H A;  2CM3 A;  3RZ2 A;  2F6V A;  4RI5 A;  3NME A;  2A3K A;  1XXP A;  3OMH A;  2OZ5 A;  4NND A;  1M3G A;  5KA8 A;  2CM7 A;  2I4G A;  2OUD A;  4ERC A;  2JJD A;  4GE2 A;  1JF7 A;  1I57 A;  4WU3 A;  5K24 A;  2F6Y A;  3V0I A;  3D1O A;  2B49 A;  3EZZ A;  2H4K A;  3S3E A;  3ZM1 A;  1Q6J A;  2H4V A;  2ESB A;  2HXP A;  5KAC A;  2I6I A;  3ZM2 A;  3PS5 A;  4GE5 A;  1U26 A;  2HCM A;  3QCM A;  3D44 A;  3O4S A;  1T49 A;  2NLK A;  3V0J A;  4RH5 A;  5KA0 A;  5KAA A;  5KA1 A;  4JMK A;  5BUG A;  2I3U A;  4S0G A;  4YR8 B;  1NZ7 A;  1YGU A;  2I4H A;  4R0S A;  4H34 A;  2HY3 A;  2B4P A;  2CNI A;  3S3H A;  2I5X A;  1U24 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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