2I5XA

Engineering the ptpbeta catalytic domain with improved crystallization properties
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
290
structure length
280
Chain Sequence
KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRAR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
pubmed doi rcsb
molecule keywords Receptor-type tyrosine-protein phosphatase beta
molecule tags Hydrolase
source organism Homo sapiens
total genus 103
structure length 280
sequence length 290
chains with identical sequence B
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2i5xA00
2RF6A 2HCMA 2CNIA 1U24A 1XM2A 1VHRA 1YFOA 2G6ZA 2GP0A 1RPMA 2C46A 2SHPA 5KA4A 4KI9A 2I4EA 4OHDA 4RH5A 3S3EA 1JLNA 2HC1A 4OHLA 2E0TA 2A8BA 5BZXA 3F9AA 2QBQA 4NWGA 2I6MA 4Y14A 2Q05A 4D3PA 1FPZA 2P6XA 2QBRA 2F6WA 2OOQA 2I6JA 4JMJA 3EB1A 3F81A 2HVLA 5K25A 2I6IA 2I6PA 5K9VA 1FQ1A 1Q6NA 3QCJA 1NWEA 1NNYA 3S3KA 2HXPA 1XXPA 5KADA 3ZMQA 5KA2A 1EEOA 4WOHA 2F6YA 1WAXA 3B7OA 4ZN5A 4QUNA 2A3KA 2FJNA 1OEUA 1ZCKA 2I42A 5BZZA 4AZ1A 4OHIA 3MOZA 3QCKA 5KA9A 3LJ8A 5LXQB 2CM2A 5K22A 2BZLA 3ZM0A 1PTTA 4RKKA 2F46A 2BGEA 4D3QA 2QDCA 4HRFA 3D9CA 1SUGA 2QCJA 4BPCA 2PA5A 3V0FA 2PQ5A 3BLUA 5I6VA 1C87A 1OHCA 2NTAA 4R0TA 1C86A 1AAXA 1NWLA 2H03A 3RGQA 2B07A 1LARA 2QBSA 2H4VA 5KA0A 3D42A 4QBEA 2ZN7A 3PS5A 2HY3A 2VEUA 3S3HA 2QCTA 4RDDA 3RO1A 1JF7A 2NT2A 1ECVA 2I5XA 3F99A 3D1QA 1U26A 3EAXA 1Q6TA 2B49A 1YTNA 1M3GA 5BX1A 2CJZA 3O3LA 1OETA 5M43A 3V0EA 1ZC0A 2H4KA 3F9BA 4JBCA 3CWEA 1FPRA 5EHRA 1C85A 1PXHA 2QDPA 3QCCA 1EENA 5IBMA 2AHSA 5KACA 2WGPA 3D1HA 2F6TA 2PT0A 3BM8A 4GFUA 1G7GA 4NYHA 2BGDA 1T49A 4HJPA 1X24A 3AWGA 1OHEA 1YGUA 1XBOA 1P15A 1U25A 2Q47A 2I1YA 2VEVA 4J51A 2CNFA 2IMGA 1T48A 1G1GA 3S4EA 4QAHA 1BZHA 2B4PA 2NZ6A 2CMCA 4YR8B 2CNEA 1RXDA 2CFVA 3ZM1A 2BIJA 1PTVA 4RI5A 1T4JA 1A5YA 4TVVA 1BZCA 2H02A 1J4XA 3EZZA 1WRMA 4D3RA 2CNHA 4WTYA 2NLKA 1ZCLA 2QBPA 4GRZA 2MBCA 1WCHA 1YTWA 5KA3A 2DXPA 4MBBA 2PSZA 4IKCA 1LYVA 1PA9A 2OZ5A 5K24A 1L8GA 2F70A 2G59A 4H34A 3V0DA 4Z6BA 1C84A 2NV5A 2YDUA 3H2XA 3ZM3A 4PVGA 3QCEA 1D5RA 1Q1MA 2HNQA 3D44A 3RZ2A 2FH7A 2ZMMA 1YTSA 2OC3A 4WU2A 3QCHA 3GXHA 4RHGA 1G4US 4JMKA 1YN9A 3N0AA 4H1OA 1OEVA 2CMAA 1C83A 2J16B 4KYRA 2PBNA 3A5KA 1GFYA 2VEYA 3QKPA 1XRIA 1OHDA 1KAVA 2B4OA 3OLRA 2F6ZA 1ONYA 4R30A 4YAAA 4DGPA 1KAKA 3O4SA 5KA7A 2R0BA 2J17A 2OUDA 2JJDA 3QCIA 2CM3A 3BLTA 1PH0A 3CM3A 3S4OA 2PI7A 3MOWA 3EU0A 2I75A 4NX8A 4GFVA 3QCLA 2B3OA 2CM7A 1Q6PA 1PYNA 4Y2EA 5HDEA 3ZV2A 3V0GA 4B04A 3AWEA 3V0IA 2QDMA 1YZ4A 3NMEA 1OEOX 4GWFA 3EMUA 5KA8A 4JNBA 3SMEA 3SR9A 5J8RA 1Q6SA 1I9TA 5KABA 4OHHA 3AWFA 1QXKA 1YWFA 3ZM2A 1MKPA 5GTJA 2Y96A 1BZJA 3QCNA 4GS0A 2CMBA 3I7ZA 1QZ0A 3I36A 1L8KA 3QCFA 4GE2A 5K9WA 1C88A 3MMJA 2C7SA 5EHPA 1ONZA 2I3UA 3O5XA 3O4TA 4DGXA 2VEXA 4QUMA 2F6VA 4RH9A 3V0HA 4QBWA 2AZRA 1PTUA 4NWFA 2VEWA 1LQFA 1Q6MA 4I8NA 2HB1A 1ZZWA 3GXGA 3V0JA 3QKQA 1OESA 5BUGA 1V3AA 1XXVA 3A5JA 3U96A 3QCDA 3BRHA 1PTYA 1NZ7A 2I6OA 1G1HA 2B4SA 4S0GA 1PA1A 2I4HA 2B4UA 2I3RA 2HNPA 2CM8A 4BJOA 4WU3A 5AWXA 5KA1A 3I80A 4ZI4A 2M3VA 1I57A 2QEPA 5KAAA 5MMZB 3RGOA 2H4GA 2BV5A 2P4DA 2I4GA 4OHEA 3D1OA 4HJQA 3M4UA 1NO6A 1NL9A 3OMHA 4QAPA 2NT7A 4R0SA 1R6HA 2GWOA 4GRYA 1YGRA 4KYQA 3QCBA 4ICZA 4GE6A 1G7FA 1OEMX 5IBSA 2FJMA 3S3FA 2J16A 2CNGA 3ZMPA 2H04A 1G4WR 5K23A 1Q6JA 2F71A 4ERCA 3O4UA 1G1FA 4PYHA 3QCMA 2HC2A 3F41A 4RI4A 4ZRTA 1YPTA 4NNDA 2F6FA 1GWZA 2GJTA 1I9SA 2Y2FA 4GE5A 3QCGA 2ESBA
chains in the Genus database with same CATH superfamily
2RF6A 2HCMA 2CNIA 1U24A 1XM2A 1VHRA 1YFOA 2G6ZA 2GP0A 1RPMA 3PYZA 2C46A 2SHPA 5KA4A 4KI9A 2I4EA 4OHDA 4RH5A 3S3EA 1JLNA 2HC1A 4OHLA 2E0TA 3ZL8A 2A8BA 5BZXA 3F9AA 2QBQA 4NWGA 2I6MA 2VOSA 4Y14A 2Q05A 4D3PA 1FPZA 2P6XA 2QBRA 2F6WA 2OOQA 2I6JA 4JMJA 3EB1A 2VTEA 3F81A 2HVLA 5K25A 2I6IA 2I6PA 5K9VA 1FQ1A 1Q6NA 3QCZA 3QCJA 1NWEA 3UAGA 4QF5A 1NNYA 4HV4A 3S3KA 2HXPA 1XXPA 5KADA 3ZMQA 5KA2A 1EEOA 4WOHA 2F6YA 1WAXA 3B7OA 4ZN5A 3N2AA 2A3KA 4QUNA 2FJNA 1OEUA 1ZCKA 2I42A 5BZZA 4AZ1A 4OHIA 3MOZA 4CVKA 3QCKA 5KA9A 3LJ8A 1UAGA 5LXQB 2CM2A 5K22A 2VORA 5A5EA 2BZLA 3ZM0A 1PTTA 4RKKA 2F46A 2BGEA 4D3QA 2QDCA 4HRFA 3D9CA 1SUGA 2QCJA 4BPCA 2PA5A 3V0FA 2PQ5A 3BLUA 5I6VA 1C87A 1OHCA 1FGSA 2NTAA 4R0TA 4ZIYA 1C86A 1AAXA 1NWLA 2H03A 3RGQA 2B07A 1LARA 2QBSA 2H4VA 5KA0A 3D42A 4QBEA 2ZN7A 1E8CA 1EEHA 4BUBA 3PS5A 2HY3A 2VEUA 3S3HA 4C12A 2QCTA 4RDDA 3RO1A 1JF7A 2NT2A 1ECVA 2I5XA 3F99A 3D1QA 1U26A 2GCBA 3EAXA 1Q6TA 2B49A 1YTNA 1M3GA 5BX1A 2CJZA 3O3LA 1OETA 5M43A 3V0EA 1W7KA 1ZC0A 2H4KA 3F9BA 3ZM5A 4JBCA 2XJAA 3CWEA 1FPRA 5EHRA 1C85A 1PXHA 2QDPA 3QCCA 2AM1A 1EENA 5IBMA 2AHSA 5KACA 2WGPA 4QDIA 3D1HA 2F6TA 2PT0A 3BM8A 4GFUA 1G7GA 4NYHA 1JBVA 2BGDA 1T49A 4HJPA 4C13A 1X24A 3AWGA 3MVNA 1OHEA 1YGUA 2Y67A 1XBOA 1P15A 1U25A 2Q47A 2I1YA 2VEVA 4J51A 2CNFA 2IMGA 1T48A 1G1GA 2F00A 3S4EA 4QAHA 1BZHA 2B4PA 2NZ6A 2VTDA 2CMCA 4YR8B 2CNEA 1RXDA 2CFVA 3ZM1A 2BIJA 1PTVA 4RI5A 1T4JA 1A5YA 4TVVA 1BZCA 2H02A 1J4XA 3EZZA 1WRMA 4D3RA 2CNHA 4WTYA 2NLKA 1ZCLA 2QBPA 4GRZA 2MBCA 1WCHA 1YTWA 2X5OA 5KA3A 2DXPA 4MBBA 2PSZA 1GQQA 4IKCA 1LYVA 1PA9A 2OZ5A 5K24A 1L8GA 2F70A 2G59A 4H34A 3V0DA 4Z6BA 1C84A 2NV5A 2YDUA 3H2XA 3ZM3A 4PVGA 2JFHA 3QCEA 1D5RA 1P3DA 1Q1MA 2HNQA 3D44A 3RZ2A 2FH7A 2ZMMA 1YTSA 2OC3A 4WU2A 3QCHA 3GXHA 4RHGA 1G4US 4JMKA 1YN9A 3N0AA 4H1OA 1OEVA 2AM2A 2CMAA 1C83A 4CVMA 2J16B 4KYRA 1GQYA 2PBNA 3A5KA 1GFYA 2WTZA 2VEYA 3QKPA 1XRIA 1OHDA 1KAVA 2B4OA 3OLRA 2F6ZA 1ONYA 2GC5A 3NRSA 4R30A 4YAAA 4DGPA 1KAKA 4BUCA 3O4SA 5KA7A 2R0BA 2J17A 2OUDA 2JJDA 3QCIA 2CM3A 3BLTA 1PH0A 3CM3A 2JFFA 3S4OA 2PI7A 3MOWA 3EU0A 2I75A 4NX8A 4GFVA 3QCLA 2B3OA 2CM7A 1GG4A 1Q6PA 1PYNA 4Y2EA 5HDEA 2XPCA 3ZV2A 3V0GA 4B04A 3AWEA 3V0IA 2QDMA 1YZ4A 3ZM6A 3NMEA 1OEOX 4GWFA 3EMUA 5KA8A 4JNBA 4UAGA 3SMEA 3SR9A 5J8RA 1Q6SA 1I9TA 5KABA 4OHHA 3AWFA 1QXKA 1YWFA 3ZM2A 1MKPA 5GTJA 2Y96A 1BZJA 3QCNA 4GS0A 2CMBA 2Y66A 3I7ZA 1QZ0A 3I36A 1L8KA 3QCFA 4GE2A 2Y68A 5K9WA 1C88A 2UUPA 3MMJA 2C7SA 5EHPA 2JFGA 1ONZA 2I3UA 3O5XA 2UUOA 3O4TA 4DGXA 2VEXA 4QUMA 2F6VA 4RH9A 3V0HA 4QBWA 2WJPA 2AZRA 1PTUA 4NWFA 2VEWA 3HN7A 1LQFA 1Q6MA 4I8NA 1P31A 2HB1A 3LK7A 1J6UA 1ZZWA 3GXGA 3V0JA 3QKQA 1OESA 5BUGA 1JBWA 1V3AA 1XXVA 2GC6A 3A5JA 3U96A 3QCDA 3BRHA 1PTYA 1NZ7A 2I6OA 1G1HA 2B4SA 4S0GA 1PA1A 2I4HA 2B4UA 2I3RA 2HNPA 2CM8A 4BJOA 4WU3A 5AWXA 5KA1A 3I80A 4ZI4A 2M3VA 1I57A 2UAGA 2QEPA 5KAAA 5MMZB 3RGOA 2H4GA 2BV5A 2P4DA 2I4GA 4OHEA 3D1OA 1E0DA 4HJQA 3M4UA 1NO6A 1NL9A 3OMHA 4QAPA 2Y1OA 2NT7A 4R0SA 5A5FA 1R6HA 2GWOA 4GRYA 1YGRA 4CVLA 4KYQA 3QCBA 4ICZA 4GE6A 1G7FA 1OEMX 5IBSA 2FJMA 3S3FA 2J16A 2CNGA 3ZMPA 2H04A 1G4WR 1O5ZA 5K23A 1Q6JA 2F71A 4ERCA 3O4UA 1G1FA 1W78A 4PYHA 3QCMA 2HC2A 3F41A 4RI4A 4ZRTA 2GCAA 1YPTA 4NNDA 2F6FA 1GWZA 2GJTA 1I9SA 2Y2FA 4GE5A 3QCGA 2ESBA
chains in the Genus database with same CATH topology
2RF6A 2HCMA 2CNIA 1U24A 1XM2A 1VHRA 1YFOA 2G6ZA 2GP0A 1RPMA 2C46A 2SHPA 5KA4A 4KI9A 2I4EA 4OHDA 4RH5A 3S3EA 1JLNA 2HC1A 4OHLA 2E0TA 2A8BA 5BZXA 3F9AA 2QBQA 4NWGA 2I6MA 4Y14A 2Q05A 4D3PA 1FPZA 2P6XA 2QBRA 2F6WA 2OOQA 2I6JA 4JMJA 3EB1A 3F81A 2HVLA 5K25A 2I6IA 2I6PA 5K9VA 1FQ1A 1Q6NA 3QCJA 1NWEA 1NNYA 3S3KA 2HXPA 1XXPA 5KADA 3ZMQA 5KA2A 1EEOA 4WOHA 2F6YA 1WAXA 3B7OA 4ZN5A 4QUNA 2A3KA 2FJNA 1OEUA 1ZCKA 2I42A 5BZZA 4AZ1A 4OHIA 3MOZA 3QCKA 5KA9A 3LJ8A 5LXQB 2CM2A 5K22A 2BZLA 3ZM0A 1PTTA 4RKKA 2F46A 2BGEA 4D3QA 2QDCA 4HRFA 3D9CA 1SUGA 2QCJA 4BPCA 2PA5A 3V0FA 2PQ5A 3BLUA 5I6VA 1C87A 1OHCA 2NTAA 4R0TA 1C86A 1AAXA 1NWLA 2H03A 3RGQA 2B07A 1LARA 2QBSA 2H4VA 5KA0A 3D42A 4QBEA 2ZN7A 3PS5A 2HY3A 2VEUA 3S3HA 2QCTA 4RDDA 3RO1A 1JF7A 2NT2A 1ECVA 2I5XA 3F99A 3D1QA 1U26A 3EAXA 1Q6TA 2B49A 1YTNA 1M3GA 5BX1A 2CJZA 3O3LA 1OETA 5M43A 3V0EA 1ZC0A 2H4KA 3F9BA 4JBCA 3CWEA 1FPRA 5EHRA 1C85A 1PXHA 2QDPA 3QCCA 1EENA 5IBMA 2AHSA 5KACA 2WGPA 3D1HA 2F6TA 2PT0A 3BM8A 4GFUA 1G7GA 4NYHA 2BGDA 1T49A 4HJPA 1X24A 3AWGA 1OHEA 1YGUA 1XBOA 1P15A 1U25A 2Q47A 2I1YA 2VEVA 4J51A 2CNFA 2IMGA 1T48A 1G1GA 3S4EA 4QAHA 1BZHA 2B4PA 2NZ6A 2CMCA 4YR8B 2CNEA 1RXDA 2CFVA 3ZM1A 2BIJA 1PTVA 4RI5A 1T4JA 1A5YA 4TVVA 1BZCA 2H02A 1J4XA 3EZZA 1WRMA 4D3RA 2CNHA 4WTYA 2NLKA 1ZCLA 2QBPA 4GRZA 2MBCA 1WCHA 1YTWA 5KA3A 2DXPA 4MBBA 2PSZA 4IKCA 1LYVA 1PA9A 2OZ5A 5K24A 1L8GA 2F70A 2G59A 4H34A 3V0DA 4Z6BA 1C84A 2NV5A 2YDUA 3H2XA 3ZM3A 4PVGA 3QCEA 1D5RA 1Q1MA 2HNQA 3D44A 3RZ2A 2FH7A 2ZMMA 1YTSA 2OC3A 4WU2A 3QCHA 3GXHA 4RHGA 1G4US 4JMKA 1YN9A 3N0AA 4H1OA 1OEVA 2CMAA 1C83A 2J16B 4KYRA 2PBNA 3A5KA 1GFYA 2VEYA 3QKPA 1XRIA 1OHDA 1KAVA 2B4OA 3OLRA 2F6ZA 1ONYA 4R30A 4YAAA 4DGPA 1KAKA 3O4SA 5KA7A 2R0BA 2J17A 2OUDA 2JJDA 3QCIA 2CM3A 3BLTA 1PH0A 3CM3A 3S4OA 2PI7A 3MOWA 3EU0A 2I75A 4NX8A 4GFVA 3QCLA 2B3OA 2CM7A 1Q6PA 1PYNA 4Y2EA 5HDEA 3ZV2A 3V0GA 4B04A 3AWEA 3V0IA 2QDMA 1YZ4A 3NMEA 1OEOX 4GWFA 3EMUA 5KA8A 4JNBA 3SMEA 3SR9A 5J8RA 1Q6SA 1I9TA 5KABA 4OHHA 3AWFA 1QXKA 1YWFA 3ZM2A 1MKPA 5GTJA 2Y96A 1BZJA 3QCNA 4GS0A 2CMBA 3I7ZA 1QZ0A 3I36A 1L8KA 3QCFA 4GE2A 5K9WA 1C88A 3MMJA 2C7SA 5EHPA 1ONZA 2I3UA 3O5XA 3O4TA 4DGXA 2VEXA 4QUMA 2F6VA 4RH9A 3V0HA 4QBWA 2AZRA 1PTUA 4NWFA 2VEWA 1LQFA 1Q6MA 4I8NA 2HB1A 1ZZWA 3GXGA 3V0JA 3QKQA 1OESA 5BUGA 1V3AA 1XXVA 3A5JA 3U96A 3QCDA 3BRHA 1PTYA 1NZ7A 2I6OA 1G1HA 2B4SA 4S0GA 1PA1A 2I4HA 2B4UA 2I3RA 2HNPA 2CM8A 4BJOA 4WU3A 5AWXA 5KA1A 3I80A 4ZI4A 2M3VA 1I57A 2QEPA 5KAAA 5MMZB 3RGOA 2H4GA 2BV5A 2P4DA 2I4GA 4OHEA 3D1OA 4HJQA 3M4UA 1NO6A 1NL9A 3OMHA 4QAPA 2NT7A 4R0SA 1R6HA 2GWOA 4GRYA 1YGRA 4KYQA 3QCBA 4ICZA 4GE6A 1G7FA 1OEMX 5IBSA 2FJMA 3S3FA 2J16A 2CNGA 3ZMPA 2H04A 1G4WR 5K23A 1Q6JA 2F71A 4ERCA 3O4UA 1G1FA 4PYHA 3QCMA 2HC2A 3F41A 4RI4A 4ZRTA 1YPTA 4NNDA 2F6FA 1GWZA 2GJTA 1I9SA 2Y2FA 4GE5A 3QCGA 2ESBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RF6 A;  2HCM A;  2CNI A;  1U24 A;  1XM2 A;  1VHR A;  1YFO A;  2G6Z A;  2GP0 A;  1RPM A;  2C46 A;  2SHP A;  5KA4 A;  4KI9 A;  2I4E A;  4OHD A;  4RH5 A;  3S3E A;  1JLN A;  2HC1 A;  4OHL A;  2E0T A;  2A8B A;  5BZX A;  3F9A A;  2QBQ A;  4NWG A;  2I6M A;  4Y14 A;  2Q05 A;  4D3P A;  1FPZ A;  2P6X A;  2QBR A;  2F6W A;  2OOQ A;  2I6J A;  4JMJ A;  3EB1 A;  3F81 A;  2HVL A;  5K25 A;  2I6I A;  2I6P A;  5K9V A;  1FQ1 A;  1Q6N A;  3QCJ A;  1NWE A;  1NNY A;  3S3K A;  2HXP A;  1XXP A;  5KAD A;  3ZMQ A;  5KA2 A;  1EEO A;  4WOH A;  2F6Y A;  1WAX A;  3B7O A;  4ZN5 A;  4QUN A;  2A3K A;  2FJN A;  1OEU A;  1ZCK A;  2I42 A;  5BZZ A;  4AZ1 A;  4OHI A;  3MOZ A;  3QCK A;  5KA9 A;  3LJ8 A;  5LXQ B;  2CM2 A;  5K22 A;  2BZL A;  3ZM0 A;  1PTT A;  4RKK A;  2F46 A;  2BGE A;  4D3Q A;  2QDC A;  4HRF A;  3D9C A;  1SUG A;  2QCJ A;  4BPC A;  2PA5 A;  3V0F A;  2PQ5 A;  3BLU A;  5I6V A;  1C87 A;  1OHC A;  2NTA A;  4R0T A;  1C86 A;  1AAX A;  1NWL A;  2H03 A;  3RGQ A;  2B07 A;  1LAR A;  2QBS A;  2H4V A;  5KA0 A;  3D42 A;  4QBE A;  2ZN7 A;  3PS5 A;  2HY3 A;  2VEU A;  3S3H A;  2QCT A;  4RDD A;  3RO1 A;  1JF7 A;  2NT2 A;  1ECV A;  2I5X A;  3F99 A;  3D1Q A;  1U26 A;  3EAX A;  1Q6T A;  2B49 A;  1YTN A;  1M3G A;  5BX1 A;  2CJZ A;  3O3L A;  1OET A;  5M43 A;  3V0E A;  1ZC0 A;  2H4K A;  3F9B A;  4JBC A;  3CWE A;  1FPR A;  5EHR A;  1C85 A;  1PXH A;  2QDP A;  3QCC A;  1EEN A;  5IBM A;  2AHS A;  5KAC A;  2WGP A;  3D1H A;  2F6T A;  2PT0 A;  3BM8 A;  4GFU A;  1G7G A;  4NYH A;  2BGD A;  1T49 A;  4HJP A;  1X24 A;  3AWG A;  1OHE A;  1YGU A;  1XBO A;  1P15 A;  1U25 A;  2Q47 A;  2I1Y A;  2VEV A;  4J51 A;  2CNF A;  2IMG A;  1T48 A;  1G1G A;  3S4E A;  4QAH A;  1BZH A;  2B4P A;  2NZ6 A;  2CMC A;  4YR8 B;  2CNE A;  1RXD A;  2CFV A;  3ZM1 A;  2BIJ A;  1PTV A;  4RI5 A;  1T4J A;  1A5Y A;  4TVV A;  1BZC A;  2H02 A;  1J4X A;  3EZZ A;  1WRM A;  4D3R A;  2CNH A;  4WTY A;  2NLK A;  1ZCL A;  2QBP A;  4GRZ A;  2MBC A;  1WCH A;  1YTW A;  5KA3 A;  2DXP A;  4MBB A;  2PSZ A;  4IKC A;  1LYV A;  1PA9 A;  2OZ5 A;  5K24 A;  1L8G A;  2F70 A;  2G59 A;  4H34 A;  3V0D A;  4Z6B A;  1C84 A;  2NV5 A;  2YDU A;  3H2X A;  3ZM3 A;  4PVG A;  3QCE A;  1D5R A;  1Q1M A;  2HNQ A;  3D44 A;  3RZ2 A;  2FH7 A;  2ZMM A;  1YTS A;  2OC3 A;  4WU2 A;  3QCH A;  3GXH A;  4RHG A;  1G4U S;  4JMK A;  1YN9 A;  3N0A A;  4H1O A;  1OEV A;  2CMA A;  1C83 A;  2J16 B;  4KYR A;  2PBN A;  3A5K A;  1GFY A;  2VEY A;  3QKP A;  1XRI A;  1OHD A;  1KAV A;  2B4O A;  3OLR A;  2F6Z A;  1ONY A;  4R30 A;  4YAA A;  4DGP A;  1KAK A;  3O4S A;  5KA7 A;  2R0B A;  2J17 A;  2OUD A;  2JJD A;  3QCI A;  2CM3 A;  3BLT A;  1PH0 A;  3CM3 A;  3S4O A;  2PI7 A;  3MOW A;  3EU0 A;  2I75 A;  4NX8 A;  4GFV A;  3QCL A;  2B3O A;  2CM7 A;  1Q6P A;  1PYN A;  4Y2E A;  5HDE A;  3ZV2 A;  3V0G A;  4B04 A;  3AWE A;  3V0I A;  2QDM A;  1YZ4 A;  3NME A;  1OEO X;  4GWF A;  3EMU A;  5KA8 A;  4JNB A;  3SME A;  3SR9 A;  5J8R A;  1Q6S A;  1I9T A;  5KAB A;  4OHH A;  3AWF A;  1QXK A;  1YWF A;  3ZM2 A;  1MKP A;  5GTJ A;  2Y96 A;  1BZJ A;  3QCN A;  4GS0 A;  2CMB A;  3I7Z A;  1QZ0 A;  3I36 A;  1L8K A;  3QCF A;  4GE2 A;  5K9W A;  1C88 A;  3MMJ A;  2C7S A;  5EHP A;  1ONZ A;  2I3U A;  3O5X A;  3O4T A;  4DGX A;  2VEX A;  4QUM A;  2F6V A;  4RH9 A;  3V0H A;  4QBW A;  2AZR A;  1PTU A;  4NWF A;  2VEW A;  1LQF A;  1Q6M A;  4I8N A;  2HB1 A;  1ZZW A;  3GXG A;  3V0J A;  3QKQ A;  1OES A;  5BUG A;  1V3A A;  1XXV A;  3A5J A;  3U96 A;  3QCD A;  3BRH A;  1PTY A;  1NZ7 A;  2I6O A;  1G1H A;  2B4S A;  4S0G A;  1PA1 A;  2I4H A;  2B4U A;  2I3R A;  2HNP A;  2CM8 A;  4BJO A;  4WU3 A;  5AWX A;  5KA1 A;  3I80 A;  4ZI4 A;  2M3V A;  1I57 A;  2QEP A;  5KAA A;  5MMZ B;  3RGO A;  2H4G A;  2BV5 A;  2P4D A;  2I4G A;  4OHE A;  3D1O A;  4HJQ A;  3M4U A;  1NO6 A;  1NL9 A;  3OMH A;  4QAP A;  2NT7 A;  4R0S A;  1R6H A;  2GWO A;  4GRY A;  1YGR A;  4KYQ A;  3QCB A;  4ICZ A;  4GE6 A;  1G7F A;  1OEM X;  5IBS A;  2FJM A;  3S3F A;  2J16 A;  2CNG A;  3ZMP A;  2H04 A;  1G4W R;  5K23 A;  1Q6J A;  2F71 A;  4ERC A;  3O4U A;  1G1F A;  4PYH A;  3QCM A;  2HC2 A;  3F41 A;  4RI4 A;  4ZRT A;  1YPT A;  4NND A;  2F6F A;  1GWZ A;  2GJT A;  1I9S A;  2Y2F A;  4GE5 A;  3QCG A;  2ESB A; 
#chains in the Genus database with same CATH topology
 2RF6 A;  2HCM A;  2CNI A;  1U24 A;  1XM2 A;  1VHR A;  1YFO A;  2G6Z A;  2GP0 A;  1RPM A;  3PYZ A;  2C46 A;  2SHP A;  5KA4 A;  4KI9 A;  2I4E A;  4OHD A;  4RH5 A;  3S3E A;  1JLN A;  2HC1 A;  4OHL A;  2E0T A;  3ZL8 A;  2A8B A;  5BZX A;  3F9A A;  2QBQ A;  4NWG A;  2I6M A;  2VOS A;  4Y14 A;  2Q05 A;  4D3P A;  1FPZ A;  2P6X A;  2QBR A;  2F6W A;  2OOQ A;  2I6J A;  4JMJ A;  3EB1 A;  2VTE A;  3F81 A;  2HVL A;  5K25 A;  2I6I A;  2I6P A;  5K9V A;  1FQ1 A;  1Q6N A;  3QCZ A;  3QCJ A;  1NWE A;  3UAG A;  4QF5 A;  1NNY A;  4HV4 A;  3S3K A;  2HXP A;  1XXP A;  5KAD A;  3ZMQ A;  5KA2 A;  1EEO A;  4WOH A;  2F6Y A;  1WAX A;  3B7O A;  4ZN5 A;  3N2A A;  2A3K A;  4QUN A;  2FJN A;  1OEU A;  1ZCK A;  2I42 A;  5BZZ A;  4AZ1 A;  4OHI A;  3MOZ A;  4CVK A;  3QCK A;  5KA9 A;  3LJ8 A;  1UAG A;  5LXQ B;  2CM2 A;  5K22 A;  2VOR A;  5A5E A;  2BZL A;  3ZM0 A;  1PTT A;  4RKK A;  2F46 A;  2BGE A;  4D3Q A;  2QDC A;  4HRF A;  3D9C A;  1SUG A;  2QCJ A;  4BPC A;  2PA5 A;  3V0F A;  2PQ5 A;  3BLU A;  5I6V A;  1C87 A;  1OHC A;  1FGS A;  2NTA A;  4R0T A;  4ZIY A;  1C86 A;  1AAX A;  1NWL A;  2H03 A;  3RGQ A;  2B07 A;  1LAR A;  2QBS A;  2H4V A;  5KA0 A;  3D42 A;  4QBE A;  2ZN7 A;  1E8C A;  1EEH A;  4BUB A;  3PS5 A;  2HY3 A;  2VEU A;  3S3H A;  4C12 A;  2QCT A;  4RDD A;  3RO1 A;  1JF7 A;  2NT2 A;  1ECV A;  2I5X A;  3F99 A;  3D1Q A;  1U26 A;  2GCB A;  3EAX A;  1Q6T A;  2B49 A;  1YTN A;  1M3G A;  5BX1 A;  2CJZ A;  3O3L A;  1OET A;  5M43 A;  3V0E A;  1W7K A;  1ZC0 A;  2H4K A;  3F9B A;  3ZM5 A;  4JBC A;  2XJA A;  3CWE A;  1FPR A;  5EHR A;  1C85 A;  1PXH A;  2QDP A;  3QCC A;  2AM1 A;  1EEN A;  5IBM A;  2AHS A;  5KAC A;  2WGP A;  4QDI A;  3D1H A;  2F6T A;  2PT0 A;  3BM8 A;  4GFU A;  1G7G A;  4NYH A;  1JBV A;  2BGD A;  1T49 A;  4HJP A;  4C13 A;  1X24 A;  3AWG A;  3MVN A;  1OHE A;  1YGU A;  2Y67 A;  1XBO A;  1P15 A;  1U25 A;  2Q47 A;  2I1Y A;  2VEV A;  4J51 A;  2CNF A;  2IMG A;  1T48 A;  1G1G A;  2F00 A;  3S4E A;  4QAH A;  1BZH A;  2B4P A;  2NZ6 A;  2VTD A;  2CMC A;  4YR8 B;  2CNE A;  1RXD A;  2CFV A;  3ZM1 A;  2BIJ A;  1PTV A;  4RI5 A;  1T4J A;  1A5Y A;  4TVV A;  1BZC A;  2H02 A;  1J4X A;  3EZZ A;  1WRM A;  4D3R A;  2CNH A;  4WTY A;  2NLK A;  1ZCL A;  2QBP A;  4GRZ A;  2MBC A;  1WCH A;  1YTW A;  2X5O A;  5KA3 A;  2DXP A;  4MBB A;  2PSZ A;  1GQQ A;  4IKC A;  1LYV A;  1PA9 A;  2OZ5 A;  5K24 A;  1L8G A;  2F70 A;  2G59 A;  4H34 A;  3V0D A;  4Z6B A;  1C84 A;  2NV5 A;  2YDU A;  3H2X A;  3ZM3 A;  4PVG A;  2JFH A;  3QCE A;  1D5R A;  1P3D A;  1Q1M A;  2HNQ A;  3D44 A;  3RZ2 A;  2FH7 A;  2ZMM A;  1YTS A;  2OC3 A;  4WU2 A;  3QCH A;  3GXH A;  4RHG A;  1G4U S;  4JMK A;  1YN9 A;  3N0A A;  4H1O A;  1OEV A;  2AM2 A;  2CMA A;  1C83 A;  4CVM A;  2J16 B;  4KYR A;  1GQY A;  2PBN A;  3A5K A;  1GFY A;  2WTZ A;  2VEY A;  3QKP A;  1XRI A;  1OHD A;  1KAV A;  2B4O A;  3OLR A;  2F6Z A;  1ONY A;  2GC5 A;  3NRS A;  4R30 A;  4YAA A;  4DGP A;  1KAK A;  4BUC A;  3O4S A;  5KA7 A;  2R0B A;  2J17 A;  2OUD A;  2JJD A;  3QCI A;  2CM3 A;  3BLT A;  1PH0 A;  3CM3 A;  2JFF A;  3S4O A;  2PI7 A;  3MOW A;  3EU0 A;  2I75 A;  4NX8 A;  4GFV A;  3QCL A;  2B3O A;  2CM7 A;  1GG4 A;  1Q6P A;  1PYN A;  4Y2E A;  5HDE A;  2XPC A;  3ZV2 A;  3V0G A;  4B04 A;  3AWE A;  3V0I A;  2QDM A;  1YZ4 A;  3ZM6 A;  3NME A;  1OEO X;  4GWF A;  3EMU A;  5KA8 A;  4JNB A;  4UAG A;  3SME A;  3SR9 A;  5J8R A;  1Q6S A;  1I9T A;  5KAB A;  4OHH A;  3AWF A;  1QXK A;  1YWF A;  3ZM2 A;  1MKP A;  5GTJ A;  2Y96 A;  1BZJ A;  3QCN A;  4GS0 A;  2CMB A;  2Y66 A;  3I7Z A;  1QZ0 A;  3I36 A;  1L8K A;  3QCF A;  4GE2 A;  2Y68 A;  5K9W A;  1C88 A;  2UUP A;  3MMJ A;  2C7S A;  5EHP A;  2JFG A;  1ONZ A;  2I3U A;  3O5X A;  2UUO A;  3O4T A;  4DGX A;  2VEX A;  4QUM A;  2F6V A;  4RH9 A;  3V0H A;  4QBW A;  2WJP A;  2AZR A;  1PTU A;  4NWF A;  2VEW A;  3HN7 A;  1LQF A;  1Q6M A;  4I8N A;  1P31 A;  2HB1 A;  3LK7 A;  1J6U A;  1ZZW A;  3GXG A;  3V0J A;  3QKQ A;  1OES A;  5BUG A;  1JBW A;  1V3A A;  1XXV A;  2GC6 A;  3A5J A;  3U96 A;  3QCD A;  3BRH A;  1PTY A;  1NZ7 A;  2I6O A;  1G1H A;  2B4S A;  4S0G A;  1PA1 A;  2I4H A;  2B4U A;  2I3R A;  2HNP A;  2CM8 A;  4BJO A;  4WU3 A;  5AWX A;  5KA1 A;  3I80 A;  4ZI4 A;  2M3V A;  1I57 A;  2UAG A;  2QEP A;  5KAA A;  5MMZ B;  3RGO A;  2H4G A;  2BV5 A;  2P4D A;  2I4G A;  4OHE A;  3D1O A;  1E0D A;  4HJQ A;  3M4U A;  1NO6 A;  1NL9 A;  3OMH A;  4QAP A;  2Y1O A;  2NT7 A;  4R0S A;  5A5F A;  1R6H A;  2GWO A;  4GRY A;  1YGR A;  4CVL A;  4KYQ A;  3QCB A;  4ICZ A;  4GE6 A;  1G7F A;  1OEM X;  5IBS A;  2FJM A;  3S3F A;  2J16 A;  2CNG A;  3ZMP A;  2H04 A;  1G4W R;  1O5Z A;  5K23 A;  1Q6J A;  2F71 A;  4ERC A;  3O4U A;  1G1F A;  1W78 A;  4PYH A;  3QCM A;  2HC2 A;  3F41 A;  4RI4 A;  4ZRT A;  2GCA A;  1YPT A;  4NND A;  2F6F A;  1GWZ A;  2GJT A;  1I9S A;  2Y2F A;  4GE5 A;  3QCG A;  2ESB A; 
#chains in the Genus database with same CATH homology
 2RF6 A;  2HCM A;  2CNI A;  1U24 A;  1XM2 A;  1VHR A;  1YFO A;  2G6Z A;  2GP0 A;  1RPM A;  2C46 A;  2SHP A;  5KA4 A;  4KI9 A;  2I4E A;  4OHD A;  4RH5 A;  3S3E A;  1JLN A;  2HC1 A;  4OHL A;  2E0T A;  2A8B A;  5BZX A;  3F9A A;  2QBQ A;  4NWG A;  2I6M A;  4Y14 A;  2Q05 A;  4D3P A;  1FPZ A;  2P6X A;  2QBR A;  2F6W A;  2OOQ A;  2I6J A;  4JMJ A;  3EB1 A;  3F81 A;  2HVL A;  5K25 A;  2I6I A;  2I6P A;  5K9V A;  1FQ1 A;  1Q6N A;  3QCJ A;  1NWE A;  1NNY A;  3S3K A;  2HXP A;  1XXP A;  5KAD A;  3ZMQ A;  5KA2 A;  1EEO A;  4WOH A;  2F6Y A;  1WAX A;  3B7O A;  4ZN5 A;  4QUN A;  2A3K A;  2FJN A;  1OEU A;  1ZCK A;  2I42 A;  5BZZ A;  4AZ1 A;  4OHI A;  3MOZ A;  3QCK A;  5KA9 A;  3LJ8 A;  5LXQ B;  2CM2 A;  5K22 A;  2BZL A;  3ZM0 A;  1PTT A;  4RKK A;  2F46 A;  2BGE A;  4D3Q A;  2QDC A;  4HRF A;  3D9C A;  1SUG A;  2QCJ A;  4BPC A;  2PA5 A;  3V0F A;  2PQ5 A;  3BLU A;  5I6V A;  1C87 A;  1OHC A;  2NTA A;  4R0T A;  1C86 A;  1AAX A;  1NWL A;  2H03 A;  3RGQ A;  2B07 A;  1LAR A;  2QBS A;  2H4V A;  5KA0 A;  3D42 A;  4QBE A;  2ZN7 A;  3PS5 A;  2HY3 A;  2VEU A;  3S3H A;  2QCT A;  4RDD A;  3RO1 A;  1JF7 A;  2NT2 A;  1ECV A;  2I5X A;  3F99 A;  3D1Q A;  1U26 A;  3EAX A;  1Q6T A;  2B49 A;  1YTN A;  1M3G A;  5BX1 A;  2CJZ A;  3O3L A;  1OET A;  5M43 A;  3V0E A;  1ZC0 A;  2H4K A;  3F9B A;  4JBC A;  3CWE A;  1FPR A;  5EHR A;  1C85 A;  1PXH A;  2QDP A;  3QCC A;  1EEN A;  5IBM A;  2AHS A;  5KAC A;  2WGP A;  3D1H A;  2F6T A;  2PT0 A;  3BM8 A;  4GFU A;  1G7G A;  4NYH A;  2BGD A;  1T49 A;  4HJP A;  1X24 A;  3AWG A;  1OHE A;  1YGU A;  1XBO A;  1P15 A;  1U25 A;  2Q47 A;  2I1Y A;  2VEV A;  4J51 A;  2CNF A;  2IMG A;  1T48 A;  1G1G A;  3S4E A;  4QAH A;  1BZH A;  2B4P A;  2NZ6 A;  2CMC A;  4YR8 B;  2CNE A;  1RXD A;  2CFV A;  3ZM1 A;  2BIJ A;  1PTV A;  4RI5 A;  1T4J A;  1A5Y A;  4TVV A;  1BZC A;  2H02 A;  1J4X A;  3EZZ A;  1WRM A;  4D3R A;  2CNH A;  4WTY A;  2NLK A;  1ZCL A;  2QBP A;  4GRZ A;  2MBC A;  1WCH A;  1YTW A;  5KA3 A;  2DXP A;  4MBB A;  2PSZ A;  4IKC A;  1LYV A;  1PA9 A;  2OZ5 A;  5K24 A;  1L8G A;  2F70 A;  2G59 A;  4H34 A;  3V0D A;  4Z6B A;  1C84 A;  2NV5 A;  2YDU A;  3H2X A;  3ZM3 A;  4PVG A;  3QCE A;  1D5R A;  1Q1M A;  2HNQ A;  3D44 A;  3RZ2 A;  2FH7 A;  2ZMM A;  1YTS A;  2OC3 A;  4WU2 A;  3QCH A;  3GXH A;  4RHG A;  1G4U S;  4JMK A;  1YN9 A;  3N0A A;  4H1O A;  1OEV A;  2CMA A;  1C83 A;  2J16 B;  4KYR A;  2PBN A;  3A5K A;  1GFY A;  2VEY A;  3QKP A;  1XRI A;  1OHD A;  1KAV A;  2B4O A;  3OLR A;  2F6Z A;  1ONY A;  4R30 A;  4YAA A;  4DGP A;  1KAK A;  3O4S A;  5KA7 A;  2R0B A;  2J17 A;  2OUD A;  2JJD A;  3QCI A;  2CM3 A;  3BLT A;  1PH0 A;  3CM3 A;  3S4O A;  2PI7 A;  3MOW A;  3EU0 A;  2I75 A;  4NX8 A;  4GFV A;  3QCL A;  2B3O A;  2CM7 A;  1Q6P A;  1PYN A;  4Y2E A;  5HDE A;  3ZV2 A;  3V0G A;  4B04 A;  3AWE A;  3V0I A;  2QDM A;  1YZ4 A;  3NME A;  1OEO X;  4GWF A;  3EMU A;  5KA8 A;  4JNB A;  3SME A;  3SR9 A;  5J8R A;  1Q6S A;  1I9T A;  5KAB A;  4OHH A;  3AWF A;  1QXK A;  1YWF A;  3ZM2 A;  1MKP A;  5GTJ A;  2Y96 A;  1BZJ A;  3QCN A;  4GS0 A;  2CMB A;  3I7Z A;  1QZ0 A;  3I36 A;  1L8K A;  3QCF A;  4GE2 A;  5K9W A;  1C88 A;  3MMJ A;  2C7S A;  5EHP A;  1ONZ A;  2I3U A;  3O5X A;  3O4T A;  4DGX A;  2VEX A;  4QUM A;  2F6V A;  4RH9 A;  3V0H A;  4QBW A;  2AZR A;  1PTU A;  4NWF A;  2VEW A;  1LQF A;  1Q6M A;  4I8N A;  2HB1 A;  1ZZW A;  3GXG A;  3V0J A;  3QKQ A;  1OES A;  5BUG A;  1V3A A;  1XXV A;  3A5J A;  3U96 A;  3QCD A;  3BRH A;  1PTY A;  1NZ7 A;  2I6O A;  1G1H A;  2B4S A;  4S0G A;  1PA1 A;  2I4H A;  2B4U A;  2I3R A;  2HNP A;  2CM8 A;  4BJO A;  4WU3 A;  5AWX A;  5KA1 A;  3I80 A;  4ZI4 A;  2M3V A;  1I57 A;  2QEP A;  5KAA A;  5MMZ B;  3RGO A;  2H4G A;  2BV5 A;  2P4D A;  2I4G A;  4OHE A;  3D1O A;  4HJQ A;  3M4U A;  1NO6 A;  1NL9 A;  3OMH A;  4QAP A;  2NT7 A;  4R0S A;  1R6H A;  2GWO A;  4GRY A;  1YGR A;  4KYQ A;  3QCB A;  4ICZ A;  4GE6 A;  1G7F A;  1OEM X;  5IBS A;  2FJM A;  3S3F A;  2J16 A;  2CNG A;  3ZMP A;  2H04 A;  1G4W R;  5K23 A;  1Q6J A;  2F71 A;  4ERC A;  3O4U A;  1G1F A;  4PYH A;  3QCM A;  2HC2 A;  3F41 A;  4RI4 A;  4ZRT A;  1YPT A;  4NND A;  2F6F A;  1GWZ A;  2GJT A;  1I9S A;  2Y2F A;  4GE5 A;  3QCG A;  2ESB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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