1PYNA

Dual-site potent, selective protein tyrosine phosphatase 1b inhibitor using a linked fragment strategy and a malonate head on the first site
Total Genus 100
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
282
structure length
282
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
pubmed doi rcsb
molecule keywords Protein-tyrosine phosphatase, non-receptor type 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 100
structure length 282
sequence length 282
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2003-07-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 1pynA00
4RI4A 5KADA 2NLKA 1OEOX 5KA8A 2B3OA 2OOQA 2GWOA 4Y14A 3AWEA 2B4OA 5BX1A 4I8NA 4KYQA 3S3EA 5EHPA 1BZCA 1ZC0A 2FJMA 1QXKA 1OHEA 2C7SA 1PYNA 1ECVA 1L8KA 3O3LA 4GE5A 1G1FA 1EEOA 4OHDA 1GFYA 1XBOA 1YTSA 4QAHA 2H03A 1G4US 2F6VA 1FPZA 2ZN7A 2CNGA 4ERCA 1U25A 2HC2A 2SHPA 4RH5A 5K25A 1NZ7A 2OUDA 1YGRA 2F6FA 4DGPA 4QAPA 1XRIA 3LJ8A 4GRYA 1BZHA 4NWFA 2I3UA 4WU2A 1Q6JA 4OHIA 2B4UA 1YTNA 1NNYA 1XXPA 3H2XA 2CMBA 3N0AA 3RO1A 2B4SA 1Q6MA 4R0SA 3BRHA 4JMJA 1NWEA 2CMCA 3S4OA 3ZM2A 2MBCA 1V3AA 2QCTA 2CMAA 2F46A 5K24A 4DGXA 2I4GA 2J17A 2FJNA 3QCBA 2I4EA 4IKCA 2NTAA 3A5JA 2HY3A 2BGDA 3MOZA 1A5YA 3I80A 2B4PA 1PTTA 3EAXA 1OEUA 3B7OA 1Q6NA 1T49A 3QCFA 4H1OA 4B04A 5K22A 4OHLA 1C84A 3SMEA 1C87A 3F9AA 3EU0A 2QDMA 5MMZB 4KYRA 3ZM3A 2PT0A 3D42A 3D1OA 2PSZA 2I42A 2QDPA 1Q6TA 3V0GA 3O5XA 1RXDA 2I5XA 2CM8A 4D3QA 1PTUA 3V0FA 2HNPA 2Q05A 1C85A 1LYVA 1OEVA 2WGPA 2FH7A 3D1QA 1P15A 2I75A 1PA1A 2F6YA 4AZ1A 2I3RA 2QCJA 3F41A 2VEUA 2QBQA 4Y2EA 3AWFA 1YWFA 4WU3A 2I1YA 4RH9A 3V0DA 2CNEA 4QUMA 1Q6SA 2CNHA 3QCIA 3SR9A 3QKPA 2HB1A 1I9SA 2H02A 2CJZA 2M3VA 2CNIA 2NZ6A 3V0JA 3AWGA 3EMUA 3QCGA 5J8RA 1YFOA 2PBNA 4RKKA 4NYHA 1WCHA 5IBMA 4TVVA 2VEWA 4JMKA 1EENA 2NT7A 5KA2A 3ZMPA 4ZN5A 1YZ4A 5KACA 3D1HA 4GS0A 1T4JA 5M43A 1MKPA 1U26A 2NT2A 4YAAA 2Y96A 2I6MA 5K9VA 2BGEA 2CM2A 5K9WA 4HRFA 1I57A 1SUGA 2Y2FA 4RHGA 2VEXA 4QBWA 1ZCKA 4QBEA 2ESBA 2H4VA 2H4KA 1Q1MA 1PTVA 1OETA 2C46A 3MOWA 4PVGA 5HDEA 4RI5A 2F6TA 2CM3A 3EB1A 4ZRTA 1J4XA 1JLNA 1ZCLA 2I6PA 2ZMMA 1ONYA 2VEYA 1Q6PA 1LQFA 4NX8A 3QKQA 5LXQB 1G4WR 2PI7A 5KA7A 4RDDA 3O4UA 5KA3A 3A5KA 4H34A 3ZM0A 1G7GA 4JNBA 3QCNA 4MBBA 4R0TA 1BZJA 1ONZA 2G6ZA 5I6VA 2IMGA 1PTYA 1OESA 2G59A 4BJOA 4J51A 1XXVA 3BLUA 2QEPA 2PQ5A 2NV5A 3I36A 3ZMQA 2BZLA 2GJTA 1OEMX 1KAKA 2I4HA 5KA0A 4BPCA 2BIJA 3QCKA 2R0BA 3CM3A 1X24A 1WRMA 3NMEA 3V0HA 3M4UA 3D44A 2BV5A 4R30A 3S3KA 4ICZA 1NO6A 2YDUA 3RGQA 2AZRA 2E0TA 3F9BA 1PA9A 2OZ5A 3F99A 5AWXA 4HJPA 1G7FA 1YGUA 4WTYA 2H4GA 3GXHA 4OHHA 3V0EA 2B49A 2QDCA 2DXPA 2I6OA 1GWZA 2I6JA 3QCCA 2GP0A 4ZI4A 2QBSA 3BLTA 4WOHA 3S4EA 3U96A 3OLRA 3QCLA 1C86A 2A3KA 3QCMA 5BUGA 4S0GA 2B07A 4GE2A 3O4TA 1NWLA 4D3RA 1T48A 5GTJA 2QBPA 1G1HA 3F81A 4OHEA 1ZZWA 3RGOA 4Z6BA 3V0IA 3ZM1A 2F6ZA 1YN9A 3PS5A 2P6XA 4KI9A 1NL9A 1D5RA 1OHCA 2VEVA 1AAXA 2HNQA 2JJDA 5KA9A 1FPRA 1JF7A 1U24A 1RPMA 2F6WA 2HXPA 3QCJA 1G1GA 1C88A 2OC3A 3S3FA 5K23A 2HVLA 1YTWA 2AHSA 5KAAA 3MMJA 5KA1A 1M3GA 1L8GA 3OMHA 5BZXA 2CM7A 5KA4A 1FQ1A 4D3PA 1PXHA 1PH0A 4GE6A 2HC1A 4QUNA 2PA5A 1OHDA 1YPTA 2J16B 1XM2A 1LARA 2CFVA 4NNDA 4YR8B 2F70A 2I6IA 4PYHA 4GFVA 3S3HA 3QCEA 3BM8A 3CWEA 1WAXA 1R6HA 2Q47A 1QZ0A 1VHRA 3ZV2A 3I7ZA 1I9TA 1KAVA 3EZZA 3GXGA 4HJQA 4NWGA 3RZ2A 1C83A 2HCMA 3D9CA 2CNFA 4JBCA 2A8BA 2F71A 4GWFA 4GRZA 2RF6A 2P4DA 5IBSA 3O4SA 3QCDA 2H04A 2J16A 5BZZA 5KABA 2QBRA 5EHRA 4GFUA 3QCHA
chains in the Genus database with same CATH superfamily
4RI4A 5KADA 2NLKA 5A5FA 1OEOX 1E8CA 5KA8A 2B3OA 2OOQA 2GWOA 4Y14A 3AWEA 2B4OA 2WTZA 5BX1A 4I8NA 4KYQA 3S3EA 5EHPA 1BZCA 1ZC0A 2FJMA 1QXKA 1OHEA 2C7SA 1PYNA 4ZIYA 1ECVA 1L8KA 2UAGA 3O3LA 4GE5A 2XPCA 1G1FA 1EEOA 4OHDA 1GFYA 1XBOA 1YTSA 4QAHA 2H03A 1G4US 2F6VA 1FPZA 2ZN7A 2CNGA 4ERCA 1U25A 2HC2A 2X5OA 2SHPA 4RH5A 5K25A 1NZ7A 2OUDA 1YGRA 2F6FA 1GG4A 4DGPA 4QAPA 1XRIA 3LJ8A 4GRYA 1BZHA 4NWFA 1GQQA 2I3UA 4WU2A 1Q6JA 4OHIA 2B4UA 1YTNA 1NNYA 1XXPA 1E0DA 3H2XA 2CMBA 3N0AA 3RO1A 2B4SA 1Q6MA 4R0SA 3BRHA 4JMJA 1NWEA 2CMCA 3S4OA 3ZM2A 2MBCA 2XJAA 4CVKA 1V3AA 2QCTA 2CMAA 2F46A 5K24A 4DGXA 3HN7A 2I4GA 2J17A 2FJNA 2Y66A 3QCBA 2I4EA 4IKCA 2NTAA 3A5JA 2HY3A 2BGDA 3MOZA 1A5YA 3I80A 2JFFA 2B4PA 1PTTA 3EAXA 1OEUA 3B7OA 1Q6NA 4CVLA 1T49A 3QCFA 4H1OA 4B04A 5K22A 4OHLA 1C84A 3SMEA 3PYZA 1C87A 3F9AA 3EU0A 2QDMA 5MMZB 4KYRA 3ZM3A 2PT0A 3D42A 3D1OA 2PSZA 2I42A 2QDPA 1Q6TA 3V0GA 3O5XA 1RXDA 2I5XA 2CM8A 5A5EA 4D3QA 1PTUA 3V0FA 2GC6A 2HNPA 2Q05A 1C85A 1LYVA 4QF5A 2VTDA 1JBWA 1OEVA 2WGPA 2FH7A 3D1QA 1P15A 2I75A 1PA1A 2F6YA 4AZ1A 4CVMA 2I3RA 2QCJA 3ZM6A 3F41A 2VEUA 2QBQA 4Y2EA 3AWFA 1YWFA 4WU3A 2I1YA 4RH9A 3V0DA 2F00A 2CNEA 4QUMA 1Q6SA 2CNHA 3QCIA 3SR9A 3QKPA 2HB1A 3ZM5A 2GCAA 1I9SA 2VTEA 2H02A 2CJZA 2M3VA 2CNIA 2NZ6A 3V0JA 1O5ZA 3AWGA 3EMUA 3QCGA 5J8RA 1YFOA 2PBNA 4RKKA 3UAGA 4NYHA 1WCHA 5IBMA 4TVVA 2VEWA 4JMKA 1EENA 2NT7A 5KA2A 3ZMPA 4ZN5A 1YZ4A 5KACA 3D1HA 4GS0A 2UUOA 1T4JA 5M43A 1MKPA 1U26A 2NT2A 4YAAA 2Y96A 2I6MA 5K9VA 2BGEA 2CM2A 5K9WA 3LK7A 4HRFA 1I57A 1SUGA 2Y2FA 4RHGA 2VEXA 4QBWA 1ZCKA 4QBEA 2GCBA 2ESBA 2H4VA 2H4KA 1Q1MA 1PTVA 1OETA 2C46A 3MOWA 4PVGA 5HDEA 4RI5A 2F6TA 2CM3A 3EB1A 3NRSA 4ZRTA 1J4XA 1JLNA 1ZCLA 2I6PA 2ZMMA 4UAGA 1ONYA 2VEYA 1Q6PA 1LQFA 4NX8A 3QKQA 5LXQB 4HV4A 1G4WR 2PI7A 2AM2A 5KA7A 2AM1A 4RDDA 3O4UA 5KA3A 3A5KA 4H34A 3ZM0A 1G7GA 4JNBA 3QCNA 4MBBA 4R0TA 1BZJA 1ONZA 2G6ZA 5I6VA 2IMGA 1PTYA 2Y1OA 1OESA 2G59A 1UAGA 4BJOA 4J51A 1XXVA 3BLUA 2QEPA 2PQ5A 2NV5A 2Y67A 3I36A 3ZMQA 2BZLA 2GJTA 1OEMX 1KAKA 2I4HA 5KA0A 4BPCA 2BIJA 3QCKA 2R0BA 3CM3A 1X24A 1WRMA 3NMEA 3V0HA 3M4UA 3D44A 4BUCA 1P31A 2BV5A 3ZL8A 4R30A 3S3KA 4ICZA 1NO6A 2YDUA 3RGQA 2AZRA 2JFGA 2E0TA 3F9BA 1PA9A 2OZ5A 3F99A 5AWXA 4HJPA 1G7FA 1YGUA 4WTYA 2H4GA 3GXHA 2WJPA 4OHHA 3V0EA 3N2AA 2B49A 2QDCA 2DXPA 2I6OA 1GWZA 2I6JA 3QCCA 2GP0A 4ZI4A 2QBSA 3BLTA 4WOHA 3S4EA 3U96A 3OLRA 1FGSA 2VOSA 3QCLA 1C86A 2A3KA 3QCMA 5BUGA 4S0GA 2B07A 4GE2A 3O4TA 1NWLA 4D3RA 1T48A 5GTJA 2QBPA 1G1HA 4C12A 3F81A 4OHEA 1ZZWA 3RGOA 4Z6BA 2GC5A 3V0IA 3ZM1A 2F6ZA 1YN9A 3PS5A 1P3DA 2P6XA 4KI9A 1NL9A 1D5RA 2Y68A 1OHCA 2VEVA 1AAXA 2HNQA 2JFHA 2JJDA 5KA9A 1FPRA 1JF7A 1U24A 1RPMA 2F6WA 2HXPA 3QCJA 1G1GA 1C88A 2OC3A 3MVNA 3S3FA 5K23A 2HVLA 1YTWA 2VORA 2AHSA 5KAAA 3MMJA 5KA1A 1M3GA 1L8GA 3OMHA 5BZXA 2CM7A 5KA4A 1FQ1A 4D3PA 3QCZA 1PXHA 4QDIA 1PH0A 4BUBA 4GE6A 2UUPA 2HC1A 1W78A 4QUNA 2PA5A 1OHDA 1EEHA 1YPTA 2J16B 1XM2A 1LARA 2CFVA 4NNDA 4YR8B 2F70A 2I6IA 1GQYA 4PYHA 4GFVA 3S3HA 3QCEA 1JBVA 3BM8A 3CWEA 1WAXA 1R6HA 2Q47A 1QZ0A 1VHRA 3ZV2A 3I7ZA 1I9TA 1KAVA 3EZZA 3GXGA 4HJQA 4NWGA 3RZ2A 1C83A 2HCMA 3D9CA 2CNFA 1W7KA 4JBCA 2A8BA 2F71A 4GWFA 4GRZA 2RF6A 2P4DA 5IBSA 3O4SA 3QCDA 2H04A 1J6UA 2J16A 4C13A 5BZZA 5KABA 2QBRA 5EHRA 4GFUA 3QCHA
chains in the Genus database with same CATH topology
4RI4A 5KADA 2NLKA 1OEOX 5KA8A 2B3OA 2OOQA 2GWOA 4Y14A 3AWEA 2B4OA 5BX1A 4I8NA 4KYQA 3S3EA 5EHPA 1BZCA 1ZC0A 2FJMA 1QXKA 1OHEA 2C7SA 1PYNA 1ECVA 1L8KA 3O3LA 4GE5A 1G1FA 1EEOA 4OHDA 1GFYA 1XBOA 1YTSA 4QAHA 2H03A 1G4US 2F6VA 1FPZA 2ZN7A 2CNGA 4ERCA 1U25A 2HC2A 2SHPA 4RH5A 5K25A 1NZ7A 2OUDA 1YGRA 2F6FA 4DGPA 4QAPA 1XRIA 3LJ8A 4GRYA 1BZHA 4NWFA 2I3UA 4WU2A 1Q6JA 4OHIA 2B4UA 1YTNA 1NNYA 1XXPA 3H2XA 2CMBA 3N0AA 3RO1A 2B4SA 1Q6MA 4R0SA 3BRHA 4JMJA 1NWEA 2CMCA 3S4OA 3ZM2A 2MBCA 1V3AA 2QCTA 2CMAA 2F46A 5K24A 4DGXA 2I4GA 2J17A 2FJNA 3QCBA 2I4EA 4IKCA 2NTAA 3A5JA 2HY3A 2BGDA 3MOZA 1A5YA 3I80A 2B4PA 1PTTA 3EAXA 1OEUA 3B7OA 1Q6NA 1T49A 3QCFA 4H1OA 4B04A 5K22A 4OHLA 1C84A 3SMEA 1C87A 3F9AA 3EU0A 2QDMA 5MMZB 4KYRA 3ZM3A 2PT0A 3D42A 3D1OA 2PSZA 2I42A 2QDPA 1Q6TA 3V0GA 3O5XA 1RXDA 2I5XA 2CM8A 4D3QA 1PTUA 3V0FA 2HNPA 2Q05A 1C85A 1LYVA 1OEVA 2WGPA 2FH7A 3D1QA 1P15A 2I75A 1PA1A 2F6YA 4AZ1A 2I3RA 2QCJA 3F41A 2VEUA 2QBQA 4Y2EA 3AWFA 1YWFA 4WU3A 2I1YA 4RH9A 3V0DA 2CNEA 4QUMA 1Q6SA 2CNHA 3QCIA 3SR9A 3QKPA 2HB1A 1I9SA 2H02A 2CJZA 2M3VA 2CNIA 2NZ6A 3V0JA 3AWGA 3EMUA 3QCGA 5J8RA 1YFOA 2PBNA 4RKKA 4NYHA 1WCHA 5IBMA 4TVVA 2VEWA 4JMKA 1EENA 2NT7A 5KA2A 3ZMPA 4ZN5A 1YZ4A 5KACA 3D1HA 4GS0A 1T4JA 5M43A 1MKPA 1U26A 2NT2A 4YAAA 2Y96A 2I6MA 5K9VA 2BGEA 2CM2A 5K9WA 4HRFA 1I57A 1SUGA 2Y2FA 4RHGA 2VEXA 4QBWA 1ZCKA 4QBEA 2ESBA 2H4VA 2H4KA 1Q1MA 1PTVA 1OETA 2C46A 3MOWA 4PVGA 5HDEA 4RI5A 2F6TA 2CM3A 3EB1A 4ZRTA 1J4XA 1JLNA 1ZCLA 2I6PA 2ZMMA 1ONYA 2VEYA 1Q6PA 1LQFA 4NX8A 3QKQA 5LXQB 1G4WR 2PI7A 5KA7A 4RDDA 3O4UA 5KA3A 3A5KA 4H34A 3ZM0A 1G7GA 4JNBA 3QCNA 4MBBA 4R0TA 1BZJA 1ONZA 2G6ZA 5I6VA 2IMGA 1PTYA 1OESA 2G59A 4BJOA 4J51A 1XXVA 3BLUA 2QEPA 2PQ5A 2NV5A 3I36A 3ZMQA 2BZLA 2GJTA 1OEMX 1KAKA 2I4HA 5KA0A 4BPCA 2BIJA 3QCKA 2R0BA 3CM3A 1X24A 1WRMA 3NMEA 3V0HA 3M4UA 3D44A 2BV5A 4R30A 3S3KA 4ICZA 1NO6A 2YDUA 3RGQA 2AZRA 2E0TA 3F9BA 1PA9A 2OZ5A 3F99A 5AWXA 4HJPA 1G7FA 1YGUA 4WTYA 2H4GA 3GXHA 4OHHA 3V0EA 2B49A 2QDCA 2DXPA 2I6OA 1GWZA 2I6JA 3QCCA 2GP0A 4ZI4A 2QBSA 3BLTA 4WOHA 3S4EA 3U96A 3OLRA 3QCLA 1C86A 2A3KA 3QCMA 5BUGA 4S0GA 2B07A 4GE2A 3O4TA 1NWLA 4D3RA 1T48A 5GTJA 2QBPA 1G1HA 3F81A 4OHEA 1ZZWA 3RGOA 4Z6BA 3V0IA 3ZM1A 2F6ZA 1YN9A 3PS5A 2P6XA 4KI9A 1NL9A 1D5RA 1OHCA 2VEVA 1AAXA 2HNQA 2JJDA 5KA9A 1FPRA 1JF7A 1U24A 1RPMA 2F6WA 2HXPA 3QCJA 1G1GA 1C88A 2OC3A 3S3FA 5K23A 2HVLA 1YTWA 2AHSA 5KAAA 3MMJA 5KA1A 1M3GA 1L8GA 3OMHA 5BZXA 2CM7A 5KA4A 1FQ1A 4D3PA 1PXHA 1PH0A 4GE6A 2HC1A 4QUNA 2PA5A 1OHDA 1YPTA 2J16B 1XM2A 1LARA 2CFVA 4NNDA 4YR8B 2F70A 2I6IA 4PYHA 4GFVA 3S3HA 3QCEA 3BM8A 3CWEA 1WAXA 1R6HA 2Q47A 1QZ0A 1VHRA 3ZV2A 3I7ZA 1I9TA 1KAVA 3EZZA 3GXGA 4HJQA 4NWGA 3RZ2A 1C83A 2HCMA 3D9CA 2CNFA 4JBCA 2A8BA 2F71A 4GWFA 4GRZA 2RF6A 2P4DA 5IBSA 3O4SA 3QCDA 2H04A 2J16A 5BZZA 5KABA 2QBRA 5EHRA 4GFUA 3QCHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RI4 A;  5KAD A;  2NLK A;  1OEO X;  5KA8 A;  2B3O A;  2OOQ A;  2GWO A;  4Y14 A;  3AWE A;  2B4O A;  5BX1 A;  4I8N A;  4KYQ A;  3S3E A;  5EHP A;  1BZC A;  1ZC0 A;  2FJM A;  1QXK A;  1OHE A;  2C7S A;  1PYN A;  1ECV A;  1L8K A;  3O3L A;  4GE5 A;  1G1F A;  1EEO A;  4OHD A;  1GFY A;  1XBO A;  1YTS A;  4QAH A;  2H03 A;  1G4U S;  2F6V A;  1FPZ A;  2ZN7 A;  2CNG A;  4ERC A;  1U25 A;  2HC2 A;  2SHP A;  4RH5 A;  5K25 A;  1NZ7 A;  2OUD A;  1YGR A;  2F6F A;  4DGP A;  4QAP A;  1XRI A;  3LJ8 A;  4GRY A;  1BZH A;  4NWF A;  2I3U A;  4WU2 A;  1Q6J A;  4OHI A;  2B4U A;  1YTN A;  1NNY A;  1XXP A;  3H2X A;  2CMB A;  3N0A A;  3RO1 A;  2B4S A;  1Q6M A;  4R0S A;  3BRH A;  4JMJ A;  1NWE A;  2CMC A;  3S4O A;  3ZM2 A;  2MBC A;  1V3A A;  2QCT A;  2CMA A;  2F46 A;  5K24 A;  4DGX A;  2I4G A;  2J17 A;  2FJN A;  3QCB A;  2I4E A;  4IKC A;  2NTA A;  3A5J A;  2HY3 A;  2BGD A;  3MOZ A;  1A5Y A;  3I80 A;  2B4P A;  1PTT A;  3EAX A;  1OEU A;  3B7O A;  1Q6N A;  1T49 A;  3QCF A;  4H1O A;  4B04 A;  5K22 A;  4OHL A;  1C84 A;  3SME A;  1C87 A;  3F9A A;  3EU0 A;  2QDM A;  5MMZ B;  4KYR A;  3ZM3 A;  2PT0 A;  3D42 A;  3D1O A;  2PSZ A;  2I42 A;  2QDP A;  1Q6T A;  3V0G A;  3O5X A;  1RXD A;  2I5X A;  2CM8 A;  4D3Q A;  1PTU A;  3V0F A;  2HNP A;  2Q05 A;  1C85 A;  1LYV A;  1OEV A;  2WGP A;  2FH7 A;  3D1Q A;  1P15 A;  2I75 A;  1PA1 A;  2F6Y A;  4AZ1 A;  2I3R A;  2QCJ A;  3F41 A;  2VEU A;  2QBQ A;  4Y2E A;  3AWF A;  1YWF A;  4WU3 A;  2I1Y A;  4RH9 A;  3V0D A;  2CNE A;  4QUM A;  1Q6S A;  2CNH A;  3QCI A;  3SR9 A;  3QKP A;  2HB1 A;  1I9S A;  2H02 A;  2CJZ A;  2M3V A;  2CNI A;  2NZ6 A;  3V0J A;  3AWG A;  3EMU A;  3QCG A;  5J8R A;  1YFO A;  2PBN A;  4RKK A;  4NYH A;  1WCH A;  5IBM A;  4TVV A;  2VEW A;  4JMK A;  1EEN A;  2NT7 A;  5KA2 A;  3ZMP A;  4ZN5 A;  1YZ4 A;  5KAC A;  3D1H A;  4GS0 A;  1T4J A;  5M43 A;  1MKP A;  1U26 A;  2NT2 A;  4YAA A;  2Y96 A;  2I6M A;  5K9V A;  2BGE A;  2CM2 A;  5K9W A;  4HRF A;  1I57 A;  1SUG A;  2Y2F A;  4RHG A;  2VEX A;  4QBW A;  1ZCK A;  4QBE A;  2ESB A;  2H4V A;  2H4K A;  1Q1M A;  1PTV A;  1OET A;  2C46 A;  3MOW A;  4PVG A;  5HDE A;  4RI5 A;  2F6T A;  2CM3 A;  3EB1 A;  4ZRT A;  1J4X A;  1JLN A;  1ZCL A;  2I6P A;  2ZMM A;  1ONY A;  2VEY A;  1Q6P A;  1LQF A;  4NX8 A;  3QKQ A;  5LXQ B;  1G4W R;  2PI7 A;  5KA7 A;  4RDD A;  3O4U A;  5KA3 A;  3A5K A;  4H34 A;  3ZM0 A;  1G7G A;  4JNB A;  3QCN A;  4MBB A;  4R0T A;  1BZJ A;  1ONZ A;  2G6Z A;  5I6V A;  2IMG A;  1PTY A;  1OES A;  2G59 A;  4BJO A;  4J51 A;  1XXV A;  3BLU A;  2QEP A;  2PQ5 A;  2NV5 A;  3I36 A;  3ZMQ A;  2BZL A;  2GJT A;  1OEM X;  1KAK A;  2I4H A;  5KA0 A;  4BPC A;  2BIJ A;  3QCK A;  2R0B A;  3CM3 A;  1X24 A;  1WRM A;  3NME A;  3V0H A;  3M4U A;  3D44 A;  2BV5 A;  4R30 A;  3S3K A;  4ICZ A;  1NO6 A;  2YDU A;  3RGQ A;  2AZR A;  2E0T A;  3F9B A;  1PA9 A;  2OZ5 A;  3F99 A;  5AWX A;  4HJP A;  1G7F A;  1YGU A;  4WTY A;  2H4G A;  3GXH A;  4OHH A;  3V0E A;  2B49 A;  2QDC A;  2DXP A;  2I6O A;  1GWZ A;  2I6J A;  3QCC A;  2GP0 A;  4ZI4 A;  2QBS A;  3BLT A;  4WOH A;  3S4E A;  3U96 A;  3OLR A;  3QCL A;  1C86 A;  2A3K A;  3QCM A;  5BUG A;  4S0G A;  2B07 A;  4GE2 A;  3O4T A;  1NWL A;  4D3R A;  1T48 A;  5GTJ A;  2QBP A;  1G1H A;  3F81 A;  4OHE A;  1ZZW A;  3RGO A;  4Z6B A;  3V0I A;  3ZM1 A;  2F6Z A;  1YN9 A;  3PS5 A;  2P6X A;  4KI9 A;  1NL9 A;  1D5R A;  1OHC A;  2VEV A;  1AAX A;  2HNQ A;  2JJD A;  5KA9 A;  1FPR A;  1JF7 A;  1U24 A;  1RPM A;  2F6W A;  2HXP A;  3QCJ A;  1G1G A;  1C88 A;  2OC3 A;  3S3F A;  5K23 A;  2HVL A;  1YTW A;  2AHS A;  5KAA A;  3MMJ A;  5KA1 A;  1M3G A;  1L8G A;  3OMH A;  5BZX A;  2CM7 A;  5KA4 A;  1FQ1 A;  4D3P A;  1PXH A;  1PH0 A;  4GE6 A;  2HC1 A;  4QUN A;  2PA5 A;  1OHD A;  1YPT A;  2J16 B;  1XM2 A;  1LAR A;  2CFV A;  4NND A;  4YR8 B;  2F70 A;  2I6I A;  4PYH A;  4GFV A;  3S3H A;  3QCE A;  3BM8 A;  3CWE A;  1WAX A;  1R6H A;  2Q47 A;  1QZ0 A;  1VHR A;  3ZV2 A;  3I7Z A;  1I9T A;  1KAV A;  3EZZ A;  3GXG A;  4HJQ A;  4NWG A;  3RZ2 A;  1C83 A;  2HCM A;  3D9C A;  2CNF A;  4JBC A;  2A8B A;  2F71 A;  4GWF A;  4GRZ A;  2RF6 A;  2P4D A;  5IBS A;  3O4S A;  3QCD A;  2H04 A;  2J16 A;  5BZZ A;  5KAB A;  2QBR A;  5EHR A;  4GFU A;  3QCH A; 
#chains in the Genus database with same CATH topology
 4RI4 A;  5KAD A;  2NLK A;  5A5F A;  1OEO X;  1E8C A;  5KA8 A;  2B3O A;  2OOQ A;  2GWO A;  4Y14 A;  3AWE A;  2B4O A;  2WTZ A;  5BX1 A;  4I8N A;  4KYQ A;  3S3E A;  5EHP A;  1BZC A;  1ZC0 A;  2FJM A;  1QXK A;  1OHE A;  2C7S A;  1PYN A;  4ZIY A;  1ECV A;  1L8K A;  2UAG A;  3O3L A;  4GE5 A;  2XPC A;  1G1F A;  1EEO A;  4OHD A;  1GFY A;  1XBO A;  1YTS A;  4QAH A;  2H03 A;  1G4U S;  2F6V A;  1FPZ A;  2ZN7 A;  2CNG A;  4ERC A;  1U25 A;  2HC2 A;  2X5O A;  2SHP A;  4RH5 A;  5K25 A;  1NZ7 A;  2OUD A;  1YGR A;  2F6F A;  1GG4 A;  4DGP A;  4QAP A;  1XRI A;  3LJ8 A;  4GRY A;  1BZH A;  4NWF A;  1GQQ A;  2I3U A;  4WU2 A;  1Q6J A;  4OHI A;  2B4U A;  1YTN A;  1NNY A;  1XXP A;  1E0D A;  3H2X A;  2CMB A;  3N0A A;  3RO1 A;  2B4S A;  1Q6M A;  4R0S A;  3BRH A;  4JMJ A;  1NWE A;  2CMC A;  3S4O A;  3ZM2 A;  2MBC A;  2XJA A;  4CVK A;  1V3A A;  2QCT A;  2CMA A;  2F46 A;  5K24 A;  4DGX A;  3HN7 A;  2I4G A;  2J17 A;  2FJN A;  2Y66 A;  3QCB A;  2I4E A;  4IKC A;  2NTA A;  3A5J A;  2HY3 A;  2BGD A;  3MOZ A;  1A5Y A;  3I80 A;  2JFF A;  2B4P A;  1PTT A;  3EAX A;  1OEU A;  3B7O A;  1Q6N A;  4CVL A;  1T49 A;  3QCF A;  4H1O A;  4B04 A;  5K22 A;  4OHL A;  1C84 A;  3SME A;  3PYZ A;  1C87 A;  3F9A A;  3EU0 A;  2QDM A;  5MMZ B;  4KYR A;  3ZM3 A;  2PT0 A;  3D42 A;  3D1O A;  2PSZ A;  2I42 A;  2QDP A;  1Q6T A;  3V0G A;  3O5X A;  1RXD A;  2I5X A;  2CM8 A;  5A5E A;  4D3Q A;  1PTU A;  3V0F A;  2GC6 A;  2HNP A;  2Q05 A;  1C85 A;  1LYV A;  4QF5 A;  2VTD A;  1JBW A;  1OEV A;  2WGP A;  2FH7 A;  3D1Q A;  1P15 A;  2I75 A;  1PA1 A;  2F6Y A;  4AZ1 A;  4CVM A;  2I3R A;  2QCJ A;  3ZM6 A;  3F41 A;  2VEU A;  2QBQ A;  4Y2E A;  3AWF A;  1YWF A;  4WU3 A;  2I1Y A;  4RH9 A;  3V0D A;  2F00 A;  2CNE A;  4QUM A;  1Q6S A;  2CNH A;  3QCI A;  3SR9 A;  3QKP A;  2HB1 A;  3ZM5 A;  2GCA A;  1I9S A;  2VTE A;  2H02 A;  2CJZ A;  2M3V A;  2CNI A;  2NZ6 A;  3V0J A;  1O5Z A;  3AWG A;  3EMU A;  3QCG A;  5J8R A;  1YFO A;  2PBN A;  4RKK A;  3UAG A;  4NYH A;  1WCH A;  5IBM A;  4TVV A;  2VEW A;  4JMK A;  1EEN A;  2NT7 A;  5KA2 A;  3ZMP A;  4ZN5 A;  1YZ4 A;  5KAC A;  3D1H A;  4GS0 A;  2UUO A;  1T4J A;  5M43 A;  1MKP A;  1U26 A;  2NT2 A;  4YAA A;  2Y96 A;  2I6M A;  5K9V A;  2BGE A;  2CM2 A;  5K9W A;  3LK7 A;  4HRF A;  1I57 A;  1SUG A;  2Y2F A;  4RHG A;  2VEX A;  4QBW A;  1ZCK A;  4QBE A;  2GCB A;  2ESB A;  2H4V A;  2H4K A;  1Q1M A;  1PTV A;  1OET A;  2C46 A;  3MOW A;  4PVG A;  5HDE A;  4RI5 A;  2F6T A;  2CM3 A;  3EB1 A;  3NRS A;  4ZRT A;  1J4X A;  1JLN A;  1ZCL A;  2I6P A;  2ZMM A;  4UAG A;  1ONY A;  2VEY A;  1Q6P A;  1LQF A;  4NX8 A;  3QKQ A;  5LXQ B;  4HV4 A;  1G4W R;  2PI7 A;  2AM2 A;  5KA7 A;  2AM1 A;  4RDD A;  3O4U A;  5KA3 A;  3A5K A;  4H34 A;  3ZM0 A;  1G7G A;  4JNB A;  3QCN A;  4MBB A;  4R0T A;  1BZJ A;  1ONZ A;  2G6Z A;  5I6V A;  2IMG A;  1PTY A;  2Y1O A;  1OES A;  2G59 A;  1UAG A;  4BJO A;  4J51 A;  1XXV A;  3BLU A;  2QEP A;  2PQ5 A;  2NV5 A;  2Y67 A;  3I36 A;  3ZMQ A;  2BZL A;  2GJT A;  1OEM X;  1KAK A;  2I4H A;  5KA0 A;  4BPC A;  2BIJ A;  3QCK A;  2R0B A;  3CM3 A;  1X24 A;  1WRM A;  3NME A;  3V0H A;  3M4U A;  3D44 A;  4BUC A;  1P31 A;  2BV5 A;  3ZL8 A;  4R30 A;  3S3K A;  4ICZ A;  1NO6 A;  2YDU A;  3RGQ A;  2AZR A;  2JFG A;  2E0T A;  3F9B A;  1PA9 A;  2OZ5 A;  3F99 A;  5AWX A;  4HJP A;  1G7F A;  1YGU A;  4WTY A;  2H4G A;  3GXH A;  2WJP A;  4OHH A;  3V0E A;  3N2A A;  2B49 A;  2QDC A;  2DXP A;  2I6O A;  1GWZ A;  2I6J A;  3QCC A;  2GP0 A;  4ZI4 A;  2QBS A;  3BLT A;  4WOH A;  3S4E A;  3U96 A;  3OLR A;  1FGS A;  2VOS A;  3QCL A;  1C86 A;  2A3K A;  3QCM A;  5BUG A;  4S0G A;  2B07 A;  4GE2 A;  3O4T A;  1NWL A;  4D3R A;  1T48 A;  5GTJ A;  2QBP A;  1G1H A;  4C12 A;  3F81 A;  4OHE A;  1ZZW A;  3RGO A;  4Z6B A;  2GC5 A;  3V0I A;  3ZM1 A;  2F6Z A;  1YN9 A;  3PS5 A;  1P3D A;  2P6X A;  4KI9 A;  1NL9 A;  1D5R A;  2Y68 A;  1OHC A;  2VEV A;  1AAX A;  2HNQ A;  2JFH A;  2JJD A;  5KA9 A;  1FPR A;  1JF7 A;  1U24 A;  1RPM A;  2F6W A;  2HXP A;  3QCJ A;  1G1G A;  1C88 A;  2OC3 A;  3MVN A;  3S3F A;  5K23 A;  2HVL A;  1YTW A;  2VOR A;  2AHS A;  5KAA A;  3MMJ A;  5KA1 A;  1M3G A;  1L8G A;  3OMH A;  5BZX A;  2CM7 A;  5KA4 A;  1FQ1 A;  4D3P A;  3QCZ A;  1PXH A;  4QDI A;  1PH0 A;  4BUB A;  4GE6 A;  2UUP A;  2HC1 A;  1W78 A;  4QUN A;  2PA5 A;  1OHD A;  1EEH A;  1YPT A;  2J16 B;  1XM2 A;  1LAR A;  2CFV A;  4NND A;  4YR8 B;  2F70 A;  2I6I A;  1GQY A;  4PYH A;  4GFV A;  3S3H A;  3QCE A;  1JBV A;  3BM8 A;  3CWE A;  1WAX A;  1R6H A;  2Q47 A;  1QZ0 A;  1VHR A;  3ZV2 A;  3I7Z A;  1I9T A;  1KAV A;  3EZZ A;  3GXG A;  4HJQ A;  4NWG A;  3RZ2 A;  1C83 A;  2HCM A;  3D9C A;  2CNF A;  1W7K A;  4JBC A;  2A8B A;  2F71 A;  4GWF A;  4GRZ A;  2RF6 A;  2P4D A;  5IBS A;  3O4S A;  3QCD A;  2H04 A;  1J6U A;  2J16 A;  4C13 A;  5BZZ A;  5KAB A;  2QBR A;  5EHR A;  4GFU A;  3QCH A; 
#chains in the Genus database with same CATH homology
 4RI4 A;  5KAD A;  2NLK A;  1OEO X;  5KA8 A;  2B3O A;  2OOQ A;  2GWO A;  4Y14 A;  3AWE A;  2B4O A;  5BX1 A;  4I8N A;  4KYQ A;  3S3E A;  5EHP A;  1BZC A;  1ZC0 A;  2FJM A;  1QXK A;  1OHE A;  2C7S A;  1PYN A;  1ECV A;  1L8K A;  3O3L A;  4GE5 A;  1G1F A;  1EEO A;  4OHD A;  1GFY A;  1XBO A;  1YTS A;  4QAH A;  2H03 A;  1G4U S;  2F6V A;  1FPZ A;  2ZN7 A;  2CNG A;  4ERC A;  1U25 A;  2HC2 A;  2SHP A;  4RH5 A;  5K25 A;  1NZ7 A;  2OUD A;  1YGR A;  2F6F A;  4DGP A;  4QAP A;  1XRI A;  3LJ8 A;  4GRY A;  1BZH A;  4NWF A;  2I3U A;  4WU2 A;  1Q6J A;  4OHI A;  2B4U A;  1YTN A;  1NNY A;  1XXP A;  3H2X A;  2CMB A;  3N0A A;  3RO1 A;  2B4S A;  1Q6M A;  4R0S A;  3BRH A;  4JMJ A;  1NWE A;  2CMC A;  3S4O A;  3ZM2 A;  2MBC A;  1V3A A;  2QCT A;  2CMA A;  2F46 A;  5K24 A;  4DGX A;  2I4G A;  2J17 A;  2FJN A;  3QCB A;  2I4E A;  4IKC A;  2NTA A;  3A5J A;  2HY3 A;  2BGD A;  3MOZ A;  1A5Y A;  3I80 A;  2B4P A;  1PTT A;  3EAX A;  1OEU A;  3B7O A;  1Q6N A;  1T49 A;  3QCF A;  4H1O A;  4B04 A;  5K22 A;  4OHL A;  1C84 A;  3SME A;  1C87 A;  3F9A A;  3EU0 A;  2QDM A;  5MMZ B;  4KYR A;  3ZM3 A;  2PT0 A;  3D42 A;  3D1O A;  2PSZ A;  2I42 A;  2QDP A;  1Q6T A;  3V0G A;  3O5X A;  1RXD A;  2I5X A;  2CM8 A;  4D3Q A;  1PTU A;  3V0F A;  2HNP A;  2Q05 A;  1C85 A;  1LYV A;  1OEV A;  2WGP A;  2FH7 A;  3D1Q A;  1P15 A;  2I75 A;  1PA1 A;  2F6Y A;  4AZ1 A;  2I3R A;  2QCJ A;  3F41 A;  2VEU A;  2QBQ A;  4Y2E A;  3AWF A;  1YWF A;  4WU3 A;  2I1Y A;  4RH9 A;  3V0D A;  2CNE A;  4QUM A;  1Q6S A;  2CNH A;  3QCI A;  3SR9 A;  3QKP A;  2HB1 A;  1I9S A;  2H02 A;  2CJZ A;  2M3V A;  2CNI A;  2NZ6 A;  3V0J A;  3AWG A;  3EMU A;  3QCG A;  5J8R A;  1YFO A;  2PBN A;  4RKK A;  4NYH A;  1WCH A;  5IBM A;  4TVV A;  2VEW A;  4JMK A;  1EEN A;  2NT7 A;  5KA2 A;  3ZMP A;  4ZN5 A;  1YZ4 A;  5KAC A;  3D1H A;  4GS0 A;  1T4J A;  5M43 A;  1MKP A;  1U26 A;  2NT2 A;  4YAA A;  2Y96 A;  2I6M A;  5K9V A;  2BGE A;  2CM2 A;  5K9W A;  4HRF A;  1I57 A;  1SUG A;  2Y2F A;  4RHG A;  2VEX A;  4QBW A;  1ZCK A;  4QBE A;  2ESB A;  2H4V A;  2H4K A;  1Q1M A;  1PTV A;  1OET A;  2C46 A;  3MOW A;  4PVG A;  5HDE A;  4RI5 A;  2F6T A;  2CM3 A;  3EB1 A;  4ZRT A;  1J4X A;  1JLN A;  1ZCL A;  2I6P A;  2ZMM A;  1ONY A;  2VEY A;  1Q6P A;  1LQF A;  4NX8 A;  3QKQ A;  5LXQ B;  1G4W R;  2PI7 A;  5KA7 A;  4RDD A;  3O4U A;  5KA3 A;  3A5K A;  4H34 A;  3ZM0 A;  1G7G A;  4JNB A;  3QCN A;  4MBB A;  4R0T A;  1BZJ A;  1ONZ A;  2G6Z A;  5I6V A;  2IMG A;  1PTY A;  1OES A;  2G59 A;  4BJO A;  4J51 A;  1XXV A;  3BLU A;  2QEP A;  2PQ5 A;  2NV5 A;  3I36 A;  3ZMQ A;  2BZL A;  2GJT A;  1OEM X;  1KAK A;  2I4H A;  5KA0 A;  4BPC A;  2BIJ A;  3QCK A;  2R0B A;  3CM3 A;  1X24 A;  1WRM A;  3NME A;  3V0H A;  3M4U A;  3D44 A;  2BV5 A;  4R30 A;  3S3K A;  4ICZ A;  1NO6 A;  2YDU A;  3RGQ A;  2AZR A;  2E0T A;  3F9B A;  1PA9 A;  2OZ5 A;  3F99 A;  5AWX A;  4HJP A;  1G7F A;  1YGU A;  4WTY A;  2H4G A;  3GXH A;  4OHH A;  3V0E A;  2B49 A;  2QDC A;  2DXP A;  2I6O A;  1GWZ A;  2I6J A;  3QCC A;  2GP0 A;  4ZI4 A;  2QBS A;  3BLT A;  4WOH A;  3S4E A;  3U96 A;  3OLR A;  3QCL A;  1C86 A;  2A3K A;  3QCM A;  5BUG A;  4S0G A;  2B07 A;  4GE2 A;  3O4T A;  1NWL A;  4D3R A;  1T48 A;  5GTJ A;  2QBP A;  1G1H A;  3F81 A;  4OHE A;  1ZZW A;  3RGO A;  4Z6B A;  3V0I A;  3ZM1 A;  2F6Z A;  1YN9 A;  3PS5 A;  2P6X A;  4KI9 A;  1NL9 A;  1D5R A;  1OHC A;  2VEV A;  1AAX A;  2HNQ A;  2JJD A;  5KA9 A;  1FPR A;  1JF7 A;  1U24 A;  1RPM A;  2F6W A;  2HXP A;  3QCJ A;  1G1G A;  1C88 A;  2OC3 A;  3S3F A;  5K23 A;  2HVL A;  1YTW A;  2AHS A;  5KAA A;  3MMJ A;  5KA1 A;  1M3G A;  1L8G A;  3OMH A;  5BZX A;  2CM7 A;  5KA4 A;  1FQ1 A;  4D3P A;  1PXH A;  1PH0 A;  4GE6 A;  2HC1 A;  4QUN A;  2PA5 A;  1OHD A;  1YPT A;  2J16 B;  1XM2 A;  1LAR A;  2CFV A;  4NND A;  4YR8 B;  2F70 A;  2I6I A;  4PYH A;  4GFV A;  3S3H A;  3QCE A;  3BM8 A;  3CWE A;  1WAX A;  1R6H A;  2Q47 A;  1QZ0 A;  1VHR A;  3ZV2 A;  3I7Z A;  1I9T A;  1KAV A;  3EZZ A;  3GXG A;  4HJQ A;  4NWG A;  3RZ2 A;  1C83 A;  2HCM A;  3D9C A;  2CNF A;  4JBC A;  2A8B A;  2F71 A;  4GWF A;  4GRZ A;  2RF6 A;  2P4D A;  5IBS A;  3O4S A;  3QCD A;  2H04 A;  2J16 A;  5BZZ A;  5KAB A;  2QBR A;  5EHR A;  4GFU A;  3QCH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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