1C86A

Crystal structure of protein tyrosine phosphatase 1b (r47v,d48n) complexed with 2-(oxalyl-amino-4,7-dihydro-5h-thieno[2,3-c]pyran-3-carboxylic acid
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
296
structure length
296
Chain Sequence
MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYVNVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKTYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLDMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
total genus 106
structure length 296
sequence length 296
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2000-04-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 1c86A00
1YGRA 4QBEA 2FH7A 4GRYA 3O3LA 2H02A 1G4WR 3O4SA 3QCHA 2QBSA 2ZMMA 4ERCA 4GS0A 2I3RA 2J16B 4Y2EA 4WTYA 1OHDA 1BZJA 1AAXA 1T49A 2GWOA 2A3KA 3D1QA 5KA2A 1NO6A 3A5JA 1XXPA 3GXGA 3F81A 1PH0A 2NZ6A 1XRIA 4GE5A 2JJDA 4OHEA 1YZ4A 2VEUA 1I57A 1LYVA 3MOZA 1SUGA 1QZ0A 3I7ZA 2BGEA 2HC2A 1C84A 1J4XA 1U25A 1FPZA 2HY3A 5IBSA 2H4KA 5KA9A 1OEVA 2F6ZA 2VEWA 3B7OA 2CJZA 2G6ZA 1OETA 3QCCA 5BZXA 4B04A 3RGOA 4GFUA 3D1HA 4HJPA 2I5XA 2QBRA 1BZHA 5K9WA 1Q6SA 3SMEA 4BJOA 4YR8B 2CFVA 2HCMA 1V3AA 3EMUA 2F6VA 4QUMA 1ZC0A 5KA4A 3ZM0A 5BUGA 2B4OA 2I75A 2I42A 2OZ5A 4GE2A 3QKPA 2E0TA 1YWFA 4BPCA 3AWEA 2AHSA 2C7SA 2NT7A 3D42A 3ZM1A 3RO1A 3QCDA 4QBWA 2B4SA 3S3FA 3MOWA 5K25A 1Q6MA 1OEMX 2CM2A 3BLTA 3O4UA 5EHRA 2HNPA 1G7GA 1X24A 2F71A 2GP0A 4WU2A 1ONYA 2CMCA 2F6YA 2OC3A 1YTSA 1EENA 2NTAA 3QCFA 1NZ7A 1WCHA 1Q6PA 4NX8A 5K22A 3QCNA 1EEOA 2H4GA 2QCJA 1G1FA 3EAXA 3ZMPA 3AWFA 3S4EA 2SHPA 4GWFA 3ZM2A 4JBCA 2BIJA 4H1OA 2PI7A 3M4UA 5I6VA 5KA3A 1RXDA 2J17A 2QEPA 4KYRA 2M3VA 1D5RA 2I3UA 5KAAA 5KABA 2BGDA 1L8KA 3QCLA 5KA1A 1YTWA 4NWGA 1M3GA 1PTVA 4JNBA 1OEOX 2B49A 2AZRA 1JLNA 3S4OA 1A5YA 1T48A 1C87A 1PXHA 4MBBA 3V0IA 2DXPA 4JMKA 3V0EA 1C83A 2B4PA 1PTUA 3F99A 4OHIA 5AWXA 2IMGA 2P4DA 2I4EA 1Q6NA 2PA5A 4ZI4A 3U96A 4S0GA 2I6JA 2C46A 3QCKA 1C88A 2I6OA 4KI9A 4PVGA 3QCMA 2QBQA 5LXQB 1I9SA 1LQFA 3QCEA 1G1HA 4H34A 4QUNA 4KYQA 1JF7A 5GTJA 3I80A 1KAKA 1Q6TA 4ICZA 2QBPA 1YGUA 5KADA 3S3HA 3H2XA 2B07A 2RF6A 5BZZA 3D9CA 1FQ1A 1L8GA 2OUDA 2VEXA 3MMJA 1PTYA 1G1GA 1YN9A 4I8NA 1U24A 4HJQA 2A8BA 3S3KA 4Y14A 2F6TA 2ZN7A 1PA9A 1PTTA 1PYNA 1U26A 1WRMA 2CM8A 3F9AA 3QCGA 2F6FA 4OHLA 5IBMA 4Z6BA 2HB1A 3V0JA 1MKPA 4RH9A 3OMHA 4WOHA 1FPRA 3D1OA 2I1YA 5K9VA 2ESBA 4D3PA 1ONZA 3LJ8A 1YFOA 3BM8A 2CMAA 3RGQA 1ZCKA 2MBCA 2G59A 2J16A 2B4UA 2PT0A 3V0DA 3BLUA 5K24A 3QKQA 1G7FA 2CNHA 2I6PA 1RPMA 3CM3A 1BZCA 1NNYA 4RHGA 2WGPA 2CM3A 3ZV2A 2I6IA 3SR9A 5KA8A 4NYHA 1OESA 1NWEA 1OHCA 1ZZWA 3BRHA 4DGPA 2Q05A 1WAXA 3F41A 2FJMA 1XBOA 1LARA 5HDEA 4D3RA 2YDUA 4R0SA 2PQ5A 2CNFA 1GFYA 2OOQA 2QCTA 4HRFA 3QCIA 3V0FA 1ECVA 1Q6JA 4QAPA 4NNDA 3NMEA 2Q47A 2HVLA 2QDPA 2GJTA 2CMBA 2QDMA 1OHEA 1YPTA 3N0AA 2NLKA 1PA1A 2F70A 4RKKA 3OLRA 1Q1MA 3I36A 1XXVA 5BX1A 4J51A 2H04A 1GWZA 5KACA 3EU0A 4GFVA 2NT2A 2CNIA 5M43A 1C86A 2PBNA 4TVVA 4R30A 2Y2FA 5EHPA 2Y96A 4R0TA 2PSZA 2CNEA 4DGXA 1R6HA 3PS5A 4D3QA 1KAVA 4ZN5A 1C85A 5MMZB 4GE6A 2FJNA 1XM2A 4OHDA 3QCJA 1T4JA 3ZM3A 3V0HA 3O5XA 1YTNA 2R0BA 2VEYA 3S3EA 4RH5A 5K23A 4RI5A 2P6XA 2VEVA 5J8RA 1VHRA 4YAAA 3GXHA 4AZ1A 2NV5A 4PYHA 1P15A 2HNQA 2CNGA 5KA7A 1ZCLA 2H4VA 4ZRTA 1OEUA 3ZMQA 2I6MA 4IKCA 2BV5A 3O4TA 2I4GA 4QAHA 3V0GA 2F46A 3A5KA 2CM7A 3CWEA 4NWFA 2B3OA 4OHHA 4RI4A 1NWLA 2HXPA 3RZ2A 3EB1A 1I9TA 3EZZA 4JMJA 2H03A 2I4HA 1G4US 2QDCA 1QXKA 2HC1A 4RDDA 4WU3A 3AWGA 5KA0A 2F6WA 3D44A 1NL9A 3QCBA 4GRZA 3F9BA 2BZLA
chains in the Genus database with same CATH superfamily
1YGRA 4QBEA 4UAGA 2FH7A 4GRYA 2UUPA 3O3LA 2H02A 1G4WR 3O4SA 3QCHA 2QBSA 2ZMMA 4ERCA 4GS0A 2I3RA 1EEHA 2J16B 4Y2EA 4WTYA 1OHDA 1BZJA 1AAXA 1T49A 2GWOA 2A3KA 3D1QA 5KA2A 1NO6A 4QDIA 3A5JA 1XXPA 3GXGA 1GQQA 3F81A 2WJPA 1PH0A 2NZ6A 3UAGA 1XRIA 4GE5A 2JJDA 4C12A 4OHEA 1YZ4A 2VEUA 1I57A 1LYVA 3MOZA 1SUGA 1QZ0A 3I7ZA 2Y1OA 2BGEA 2HC2A 1C84A 1J4XA 1U25A 1FPZA 2HY3A 5IBSA 2H4KA 5KA9A 1OEVA 2F6ZA 2VEWA 3B7OA 1W7KA 2CJZA 2G6ZA 2XJAA 4QF5A 1OETA 3NRSA 3QCCA 5BZXA 4B04A 3RGOA 4GFUA 3D1HA 4HJPA 2I5XA 1W78A 2QBRA 1BZHA 2UAGA 3MVNA 5K9WA 1Q6SA 3SMEA 4BJOA 4YR8B 2CFVA 2HCMA 1V3AA 3EMUA 2F6VA 4QUMA 1ZC0A 5KA4A 3ZM0A 5BUGA 2B4OA 2I75A 2GC6A 2I42A 2OZ5A 4GE2A 3QKPA 2E0TA 1YWFA 4BPCA 3AWEA 2AHSA 2C7SA 2NT7A 3D42A 3ZM1A 3RO1A 3QCDA 4BUCA 4QBWA 2B4SA 3S3FA 3MOWA 5K25A 1Q6MA 1OEMX 2CM2A 3BLTA 1J6UA 3O4UA 5EHRA 2HNPA 1G7GA 1X24A 2F71A 2GP0A 3HN7A 4WU2A 1ONYA 2CMCA 2F6YA 2OC3A 2VORA 1YTSA 1EENA 2GCBA 2NTAA 3QCFA 1NZ7A 1JBVA 1WCHA 1Q6PA 1GQYA 4NX8A 5K22A 3QCNA 1EEOA 2H4GA 2QCJA 1G1FA 3EAXA 3ZMPA 3AWFA 3S4EA 2SHPA 4GWFA 3ZM2A 4HV4A 4JBCA 3QCZA 2BIJA 4H1OA 2PI7A 3M4UA 5I6VA 5KA3A 1RXDA 2J17A 2QEPA 4KYRA 2M3VA 1D5RA 2I3UA 5KAAA 5KABA 2BGDA 1L8KA 3QCLA 5KA1A 1YTWA 4NWGA 1M3GA 1PTVA 4JNBA 1OEOX 2B49A 2Y66A 2AZRA 1JLNA 3S4OA 1A5YA 1T48A 1C87A 1PXHA 4MBBA 3V0IA 2DXPA 4JMKA 3V0EA 1C83A 2B4PA 1PTUA 3F99A 4OHIA 5AWXA 2IMGA 2P4DA 2I4EA 1Q6NA 2PA5A 4ZI4A 3U96A 4S0GA 2I6JA 2C46A 3QCKA 5A5EA 1C88A 1E0DA 2I6OA 4KI9A 4PVGA 3QCMA 1JBWA 2QBQA 5LXQB 1I9SA 1LQFA 3QCEA 1G1HA 4H34A 4QUNA 4KYQA 2Y67A 1JF7A 5GTJA 3I80A 1KAKA 1Q6TA 1FGSA 4ICZA 2QBPA 1YGUA 5KADA 2AM1A 3S3HA 3H2XA 2AM2A 2B07A 2RF6A 5BZZA 3D9CA 1FQ1A 1L8GA 2OUDA 2VEXA 3MMJA 1PTYA 1G1GA 1YN9A 4I8NA 1U24A 4HJQA 2A8BA 3S3KA 4Y14A 2F6TA 2ZN7A 1PA9A 1PTTA 1PYNA 1U26A 1WRMA 2CM8A 3F9AA 3QCGA 4CVLA 2F6FA 4OHLA 5IBMA 4Z6BA 2HB1A 3V0JA 1MKPA 2XPCA 4RH9A 3OMHA 4WOHA 1FPRA 3D1OA 2I1YA 5K9VA 2ESBA 4D3PA 1ONZA 3LJ8A 2UUOA 1YFOA 4CVMA 3BM8A 2CMAA 3RGQA 1ZCKA 2MBCA 2G59A 2J16A 1P3DA 2B4UA 2PT0A 3V0DA 3BLUA 5K24A 3QKQA 1G7FA 2CNHA 2VOSA 4CVKA 2I6PA 1RPMA 3CM3A 1BZCA 1NNYA 4RHGA 2WGPA 2CM3A 3ZV2A 2I6IA 3SR9A 5KA8A 3ZM6A 4NYHA 1OESA 1NWEA 1OHCA 1ZZWA 3BRHA 4DGPA 2Q05A 1WAXA 3F41A 2FJMA 1XBOA 1LARA 5HDEA 3ZL8A 4D3RA 2YDUA 4R0SA 2PQ5A 2CNFA 1GFYA 2OOQA 2QCTA 4HRFA 3QCIA 3V0FA 1ECVA 1Q6JA 4QAPA 2JFFA 4NNDA 2GC5A 3NMEA 2Q47A 2HVLA 2QDPA 2GJTA 2CMBA 2QDMA 1OHEA 1YPTA 1P31A 3N0AA 2NLKA 2X5OA 1PA1A 2F70A 4RKKA 3OLRA 1Q1MA 3I36A 1XXVA 3PYZA 5BX1A 4J51A 2H04A 1GWZA 5KACA 3EU0A 4GFVA 2NT2A 2CNIA 5M43A 1C86A 2PBNA 4TVVA 4R30A 2Y2FA 5EHPA 2F00A 2Y96A 4R0TA 2PSZA 2CNEA 4DGXA 1R6HA 3PS5A 4D3QA 1KAVA 4ZN5A 1C85A 5MMZB 4GE6A 2FJNA 1XM2A 2JFGA 4OHDA 3QCJA 2GCAA 1T4JA 3ZM3A 3V0HA 1GG4A 3O5XA 3LK7A 1YTNA 2R0BA 2VEYA 3S3EA 1E8CA 1UAGA 3N2AA 4RH5A 5K23A 2VTEA 5A5FA 4RI5A 2P6XA 4C13A 2VEVA 5J8RA 1VHRA 4YAAA 3GXHA 4AZ1A 2NV5A 4PYHA 1P15A 2HNQA 2CNGA 4ZIYA 2JFHA 5KA7A 1ZCLA 2H4VA 4ZRTA 1OEUA 2Y68A 3ZMQA 2I6MA 4IKCA 2BV5A 3O4TA 2I4GA 4QAHA 3V0GA 1O5ZA 2F46A 3A5KA 2CM7A 3CWEA 4NWFA 2B3OA 4OHHA 4RI4A 1NWLA 2HXPA 3RZ2A 3EB1A 1I9TA 3EZZA 4JMJA 2H03A 2I4HA 1G4US 2QDCA 1QXKA 2HC1A 2VTDA 4RDDA 4WU3A 3AWGA 4BUBA 5KA0A 2F6WA 3D44A 2WTZA 1NL9A 3QCBA 4GRZA 3F9BA 2BZLA 3ZM5A
chains in the Genus database with same CATH topology
1YGRA 4QBEA 2FH7A 4GRYA 3O3LA 2H02A 1G4WR 3O4SA 3QCHA 2QBSA 2ZMMA 4ERCA 4GS0A 2I3RA 2J16B 4Y2EA 4WTYA 1OHDA 1BZJA 1AAXA 1T49A 2GWOA 2A3KA 3D1QA 5KA2A 1NO6A 3A5JA 1XXPA 3GXGA 3F81A 1PH0A 2NZ6A 1XRIA 4GE5A 2JJDA 4OHEA 1YZ4A 2VEUA 1I57A 1LYVA 3MOZA 1SUGA 1QZ0A 3I7ZA 2BGEA 2HC2A 1C84A 1J4XA 1U25A 1FPZA 2HY3A 5IBSA 2H4KA 5KA9A 1OEVA 2F6ZA 2VEWA 3B7OA 2CJZA 2G6ZA 1OETA 3QCCA 5BZXA 4B04A 3RGOA 4GFUA 3D1HA 4HJPA 2I5XA 2QBRA 1BZHA 5K9WA 1Q6SA 3SMEA 4BJOA 4YR8B 2CFVA 2HCMA 1V3AA 3EMUA 2F6VA 4QUMA 1ZC0A 5KA4A 3ZM0A 5BUGA 2B4OA 2I75A 2I42A 2OZ5A 4GE2A 3QKPA 2E0TA 1YWFA 4BPCA 3AWEA 2AHSA 2C7SA 2NT7A 3D42A 3ZM1A 3RO1A 3QCDA 4QBWA 2B4SA 3S3FA 3MOWA 5K25A 1Q6MA 1OEMX 2CM2A 3BLTA 3O4UA 5EHRA 2HNPA 1G7GA 1X24A 2F71A 2GP0A 4WU2A 1ONYA 2CMCA 2F6YA 2OC3A 1YTSA 1EENA 2NTAA 3QCFA 1NZ7A 1WCHA 1Q6PA 4NX8A 5K22A 3QCNA 1EEOA 2H4GA 2QCJA 1G1FA 3EAXA 3ZMPA 3AWFA 3S4EA 2SHPA 4GWFA 3ZM2A 4JBCA 2BIJA 4H1OA 2PI7A 3M4UA 5I6VA 5KA3A 1RXDA 2J17A 2QEPA 4KYRA 2M3VA 1D5RA 2I3UA 5KAAA 5KABA 2BGDA 1L8KA 3QCLA 5KA1A 1YTWA 4NWGA 1M3GA 1PTVA 4JNBA 1OEOX 2B49A 2AZRA 1JLNA 3S4OA 1A5YA 1T48A 1C87A 1PXHA 4MBBA 3V0IA 2DXPA 4JMKA 3V0EA 1C83A 2B4PA 1PTUA 3F99A 4OHIA 5AWXA 2IMGA 2P4DA 2I4EA 1Q6NA 2PA5A 4ZI4A 3U96A 4S0GA 2I6JA 2C46A 3QCKA 1C88A 2I6OA 4KI9A 4PVGA 3QCMA 2QBQA 5LXQB 1I9SA 1LQFA 3QCEA 1G1HA 4H34A 4QUNA 4KYQA 1JF7A 5GTJA 3I80A 1KAKA 1Q6TA 4ICZA 2QBPA 1YGUA 5KADA 3S3HA 3H2XA 2B07A 2RF6A 5BZZA 3D9CA 1FQ1A 1L8GA 2OUDA 2VEXA 3MMJA 1PTYA 1G1GA 1YN9A 4I8NA 1U24A 4HJQA 2A8BA 3S3KA 4Y14A 2F6TA 2ZN7A 1PA9A 1PTTA 1PYNA 1U26A 1WRMA 2CM8A 3F9AA 3QCGA 2F6FA 4OHLA 5IBMA 4Z6BA 2HB1A 3V0JA 1MKPA 4RH9A 3OMHA 4WOHA 1FPRA 3D1OA 2I1YA 5K9VA 2ESBA 4D3PA 1ONZA 3LJ8A 1YFOA 3BM8A 2CMAA 3RGQA 1ZCKA 2MBCA 2G59A 2J16A 2B4UA 2PT0A 3V0DA 3BLUA 5K24A 3QKQA 1G7FA 2CNHA 2I6PA 1RPMA 3CM3A 1BZCA 1NNYA 4RHGA 2WGPA 2CM3A 3ZV2A 2I6IA 3SR9A 5KA8A 4NYHA 1OESA 1NWEA 1OHCA 1ZZWA 3BRHA 4DGPA 2Q05A 1WAXA 3F41A 2FJMA 1XBOA 1LARA 5HDEA 4D3RA 2YDUA 4R0SA 2PQ5A 2CNFA 1GFYA 2OOQA 2QCTA 4HRFA 3QCIA 3V0FA 1ECVA 1Q6JA 4QAPA 4NNDA 3NMEA 2Q47A 2HVLA 2QDPA 2GJTA 2CMBA 2QDMA 1OHEA 1YPTA 3N0AA 2NLKA 1PA1A 2F70A 4RKKA 3OLRA 1Q1MA 3I36A 1XXVA 5BX1A 4J51A 2H04A 1GWZA 5KACA 3EU0A 4GFVA 2NT2A 2CNIA 5M43A 1C86A 2PBNA 4TVVA 4R30A 2Y2FA 5EHPA 2Y96A 4R0TA 2PSZA 2CNEA 4DGXA 1R6HA 3PS5A 4D3QA 1KAVA 4ZN5A 1C85A 5MMZB 4GE6A 2FJNA 1XM2A 4OHDA 3QCJA 1T4JA 3ZM3A 3V0HA 3O5XA 1YTNA 2R0BA 2VEYA 3S3EA 4RH5A 5K23A 4RI5A 2P6XA 2VEVA 5J8RA 1VHRA 4YAAA 3GXHA 4AZ1A 2NV5A 4PYHA 1P15A 2HNQA 2CNGA 5KA7A 1ZCLA 2H4VA 4ZRTA 1OEUA 3ZMQA 2I6MA 4IKCA 2BV5A 3O4TA 2I4GA 4QAHA 3V0GA 2F46A 3A5KA 2CM7A 3CWEA 4NWFA 2B3OA 4OHHA 4RI4A 1NWLA 2HXPA 3RZ2A 3EB1A 1I9TA 3EZZA 4JMJA 2H03A 2I4HA 1G4US 2QDCA 1QXKA 2HC1A 4RDDA 4WU3A 3AWGA 5KA0A 2F6WA 3D44A 1NL9A 3QCBA 4GRZA 3F9BA 2BZLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YGR A;  4QBE A;  2FH7 A;  4GRY A;  3O3L A;  2H02 A;  1G4W R;  3O4S A;  3QCH A;  2QBS A;  2ZMM A;  4ERC A;  4GS0 A;  2I3R A;  2J16 B;  4Y2E A;  4WTY A;  1OHD A;  1BZJ A;  1AAX A;  1T49 A;  2GWO A;  2A3K A;  3D1Q A;  5KA2 A;  1NO6 A;  3A5J A;  1XXP A;  3GXG A;  3F81 A;  1PH0 A;  2NZ6 A;  1XRI A;  4GE5 A;  2JJD A;  4OHE A;  1YZ4 A;  2VEU A;  1I57 A;  1LYV A;  3MOZ A;  1SUG A;  1QZ0 A;  3I7Z A;  2BGE A;  2HC2 A;  1C84 A;  1J4X A;  1U25 A;  1FPZ A;  2HY3 A;  5IBS A;  2H4K A;  5KA9 A;  1OEV A;  2F6Z A;  2VEW A;  3B7O A;  2CJZ A;  2G6Z A;  1OET A;  3QCC A;  5BZX A;  4B04 A;  3RGO A;  4GFU A;  3D1H A;  4HJP A;  2I5X A;  2QBR A;  1BZH A;  5K9W A;  1Q6S A;  3SME A;  4BJO A;  4YR8 B;  2CFV A;  2HCM A;  1V3A A;  3EMU A;  2F6V A;  4QUM A;  1ZC0 A;  5KA4 A;  3ZM0 A;  5BUG A;  2B4O A;  2I75 A;  2I42 A;  2OZ5 A;  4GE2 A;  3QKP A;  2E0T A;  1YWF A;  4BPC A;  3AWE A;  2AHS A;  2C7S A;  2NT7 A;  3D42 A;  3ZM1 A;  3RO1 A;  3QCD A;  4QBW A;  2B4S A;  3S3F A;  3MOW A;  5K25 A;  1Q6M A;  1OEM X;  2CM2 A;  3BLT A;  3O4U A;  5EHR A;  2HNP A;  1G7G A;  1X24 A;  2F71 A;  2GP0 A;  4WU2 A;  1ONY A;  2CMC A;  2F6Y A;  2OC3 A;  1YTS A;  1EEN A;  2NTA A;  3QCF A;  1NZ7 A;  1WCH A;  1Q6P A;  4NX8 A;  5K22 A;  3QCN A;  1EEO A;  2H4G A;  2QCJ A;  1G1F A;  3EAX A;  3ZMP A;  3AWF A;  3S4E A;  2SHP A;  4GWF A;  3ZM2 A;  4JBC A;  2BIJ A;  4H1O A;  2PI7 A;  3M4U A;  5I6V A;  5KA3 A;  1RXD A;  2J17 A;  2QEP A;  4KYR A;  2M3V A;  1D5R A;  2I3U A;  5KAA A;  5KAB A;  2BGD A;  1L8K A;  3QCL A;  5KA1 A;  1YTW A;  4NWG A;  1M3G A;  1PTV A;  4JNB A;  1OEO X;  2B49 A;  2AZR A;  1JLN A;  3S4O A;  1A5Y A;  1T48 A;  1C87 A;  1PXH A;  4MBB A;  3V0I A;  2DXP A;  4JMK A;  3V0E A;  1C83 A;  2B4P A;  1PTU A;  3F99 A;  4OHI A;  5AWX A;  2IMG A;  2P4D A;  2I4E A;  1Q6N A;  2PA5 A;  4ZI4 A;  3U96 A;  4S0G A;  2I6J A;  2C46 A;  3QCK A;  1C88 A;  2I6O A;  4KI9 A;  4PVG A;  3QCM A;  2QBQ A;  5LXQ B;  1I9S A;  1LQF A;  3QCE A;  1G1H A;  4H34 A;  4QUN A;  4KYQ A;  1JF7 A;  5GTJ A;  3I80 A;  1KAK A;  1Q6T A;  4ICZ A;  2QBP A;  1YGU A;  5KAD A;  3S3H A;  3H2X A;  2B07 A;  2RF6 A;  5BZZ A;  3D9C A;  1FQ1 A;  1L8G A;  2OUD A;  2VEX A;  3MMJ A;  1PTY A;  1G1G A;  1YN9 A;  4I8N A;  1U24 A;  4HJQ A;  2A8B A;  3S3K A;  4Y14 A;  2F6T A;  2ZN7 A;  1PA9 A;  1PTT A;  1PYN A;  1U26 A;  1WRM A;  2CM8 A;  3F9A A;  3QCG A;  2F6F A;  4OHL A;  5IBM A;  4Z6B A;  2HB1 A;  3V0J A;  1MKP A;  4RH9 A;  3OMH A;  4WOH A;  1FPR A;  3D1O A;  2I1Y A;  5K9V A;  2ESB A;  4D3P A;  1ONZ A;  3LJ8 A;  1YFO A;  3BM8 A;  2CMA A;  3RGQ A;  1ZCK A;  2MBC A;  2G59 A;  2J16 A;  2B4U A;  2PT0 A;  3V0D A;  3BLU A;  5K24 A;  3QKQ A;  1G7F A;  2CNH A;  2I6P A;  1RPM A;  3CM3 A;  1BZC A;  1NNY A;  4RHG A;  2WGP A;  2CM3 A;  3ZV2 A;  2I6I A;  3SR9 A;  5KA8 A;  4NYH A;  1OES A;  1NWE A;  1OHC A;  1ZZW A;  3BRH A;  4DGP A;  2Q05 A;  1WAX A;  3F41 A;  2FJM A;  1XBO A;  1LAR A;  5HDE A;  4D3R A;  2YDU A;  4R0S A;  2PQ5 A;  2CNF A;  1GFY A;  2OOQ A;  2QCT A;  4HRF A;  3QCI A;  3V0F A;  1ECV A;  1Q6J A;  4QAP A;  4NND A;  3NME A;  2Q47 A;  2HVL A;  2QDP A;  2GJT A;  2CMB A;  2QDM A;  1OHE A;  1YPT A;  3N0A A;  2NLK A;  1PA1 A;  2F70 A;  4RKK A;  3OLR A;  1Q1M A;  3I36 A;  1XXV A;  5BX1 A;  4J51 A;  2H04 A;  1GWZ A;  5KAC A;  3EU0 A;  4GFV A;  2NT2 A;  2CNI A;  5M43 A;  1C86 A;  2PBN A;  4TVV A;  4R30 A;  2Y2F A;  5EHP A;  2Y96 A;  4R0T A;  2PSZ A;  2CNE A;  4DGX A;  1R6H A;  3PS5 A;  4D3Q A;  1KAV A;  4ZN5 A;  1C85 A;  5MMZ B;  4GE6 A;  2FJN A;  1XM2 A;  4OHD A;  3QCJ A;  1T4J A;  3ZM3 A;  3V0H A;  3O5X A;  1YTN A;  2R0B A;  2VEY A;  3S3E A;  4RH5 A;  5K23 A;  4RI5 A;  2P6X A;  2VEV A;  5J8R A;  1VHR A;  4YAA A;  3GXH A;  4AZ1 A;  2NV5 A;  4PYH A;  1P15 A;  2HNQ A;  2CNG A;  5KA7 A;  1ZCL A;  2H4V A;  4ZRT A;  1OEU A;  3ZMQ A;  2I6M A;  4IKC A;  2BV5 A;  3O4T A;  2I4G A;  4QAH A;  3V0G A;  2F46 A;  3A5K A;  2CM7 A;  3CWE A;  4NWF A;  2B3O A;  4OHH A;  4RI4 A;  1NWL A;  2HXP A;  3RZ2 A;  3EB1 A;  1I9T A;  3EZZ A;  4JMJ A;  2H03 A;  2I4H A;  1G4U S;  2QDC A;  1QXK A;  2HC1 A;  4RDD A;  4WU3 A;  3AWG A;  5KA0 A;  2F6W A;  3D44 A;  1NL9 A;  3QCB A;  4GRZ A;  3F9B A;  2BZL A; 
#chains in the Genus database with same CATH topology
 1YGR A;  4QBE A;  4UAG A;  2FH7 A;  4GRY A;  2UUP A;  3O3L A;  2H02 A;  1G4W R;  3O4S A;  3QCH A;  2QBS A;  2ZMM A;  4ERC A;  4GS0 A;  2I3R A;  1EEH A;  2J16 B;  4Y2E A;  4WTY A;  1OHD A;  1BZJ A;  1AAX A;  1T49 A;  2GWO A;  2A3K A;  3D1Q A;  5KA2 A;  1NO6 A;  4QDI A;  3A5J A;  1XXP A;  3GXG A;  1GQQ A;  3F81 A;  2WJP A;  1PH0 A;  2NZ6 A;  3UAG A;  1XRI A;  4GE5 A;  2JJD A;  4C12 A;  4OHE A;  1YZ4 A;  2VEU A;  1I57 A;  1LYV A;  3MOZ A;  1SUG A;  1QZ0 A;  3I7Z A;  2Y1O A;  2BGE A;  2HC2 A;  1C84 A;  1J4X A;  1U25 A;  1FPZ A;  2HY3 A;  5IBS A;  2H4K A;  5KA9 A;  1OEV A;  2F6Z A;  2VEW A;  3B7O A;  1W7K A;  2CJZ A;  2G6Z A;  2XJA A;  4QF5 A;  1OET A;  3NRS A;  3QCC A;  5BZX A;  4B04 A;  3RGO A;  4GFU A;  3D1H A;  4HJP A;  2I5X A;  1W78 A;  2QBR A;  1BZH A;  2UAG A;  3MVN A;  5K9W A;  1Q6S A;  3SME A;  4BJO A;  4YR8 B;  2CFV A;  2HCM A;  1V3A A;  3EMU A;  2F6V A;  4QUM A;  1ZC0 A;  5KA4 A;  3ZM0 A;  5BUG A;  2B4O A;  2I75 A;  2GC6 A;  2I42 A;  2OZ5 A;  4GE2 A;  3QKP A;  2E0T A;  1YWF A;  4BPC A;  3AWE A;  2AHS A;  2C7S A;  2NT7 A;  3D42 A;  3ZM1 A;  3RO1 A;  3QCD A;  4BUC A;  4QBW A;  2B4S A;  3S3F A;  3MOW A;  5K25 A;  1Q6M A;  1OEM X;  2CM2 A;  3BLT A;  1J6U A;  3O4U A;  5EHR A;  2HNP A;  1G7G A;  1X24 A;  2F71 A;  2GP0 A;  3HN7 A;  4WU2 A;  1ONY A;  2CMC A;  2F6Y A;  2OC3 A;  2VOR A;  1YTS A;  1EEN A;  2GCB A;  2NTA A;  3QCF A;  1NZ7 A;  1JBV A;  1WCH A;  1Q6P A;  1GQY A;  4NX8 A;  5K22 A;  3QCN A;  1EEO A;  2H4G A;  2QCJ A;  1G1F A;  3EAX A;  3ZMP A;  3AWF A;  3S4E A;  2SHP A;  4GWF A;  3ZM2 A;  4HV4 A;  4JBC A;  3QCZ A;  2BIJ A;  4H1O A;  2PI7 A;  3M4U A;  5I6V A;  5KA3 A;  1RXD A;  2J17 A;  2QEP A;  4KYR A;  2M3V A;  1D5R A;  2I3U A;  5KAA A;  5KAB A;  2BGD A;  1L8K A;  3QCL A;  5KA1 A;  1YTW A;  4NWG A;  1M3G A;  1PTV A;  4JNB A;  1OEO X;  2B49 A;  2Y66 A;  2AZR A;  1JLN A;  3S4O A;  1A5Y A;  1T48 A;  1C87 A;  1PXH A;  4MBB A;  3V0I A;  2DXP A;  4JMK A;  3V0E A;  1C83 A;  2B4P A;  1PTU A;  3F99 A;  4OHI A;  5AWX A;  2IMG A;  2P4D A;  2I4E A;  1Q6N A;  2PA5 A;  4ZI4 A;  3U96 A;  4S0G A;  2I6J A;  2C46 A;  3QCK A;  5A5E A;  1C88 A;  1E0D A;  2I6O A;  4KI9 A;  4PVG A;  3QCM A;  1JBW A;  2QBQ A;  5LXQ B;  1I9S A;  1LQF A;  3QCE A;  1G1H A;  4H34 A;  4QUN A;  4KYQ A;  2Y67 A;  1JF7 A;  5GTJ A;  3I80 A;  1KAK A;  1Q6T A;  1FGS A;  4ICZ A;  2QBP A;  1YGU A;  5KAD A;  2AM1 A;  3S3H A;  3H2X A;  2AM2 A;  2B07 A;  2RF6 A;  5BZZ A;  3D9C A;  1FQ1 A;  1L8G A;  2OUD A;  2VEX A;  3MMJ A;  1PTY A;  1G1G A;  1YN9 A;  4I8N A;  1U24 A;  4HJQ A;  2A8B A;  3S3K A;  4Y14 A;  2F6T A;  2ZN7 A;  1PA9 A;  1PTT A;  1PYN A;  1U26 A;  1WRM A;  2CM8 A;  3F9A A;  3QCG A;  4CVL A;  2F6F A;  4OHL A;  5IBM A;  4Z6B A;  2HB1 A;  3V0J A;  1MKP A;  2XPC A;  4RH9 A;  3OMH A;  4WOH A;  1FPR A;  3D1O A;  2I1Y A;  5K9V A;  2ESB A;  4D3P A;  1ONZ A;  3LJ8 A;  2UUO A;  1YFO A;  4CVM A;  3BM8 A;  2CMA A;  3RGQ A;  1ZCK A;  2MBC A;  2G59 A;  2J16 A;  1P3D A;  2B4U A;  2PT0 A;  3V0D A;  3BLU A;  5K24 A;  3QKQ A;  1G7F A;  2CNH A;  2VOS A;  4CVK A;  2I6P A;  1RPM A;  3CM3 A;  1BZC A;  1NNY A;  4RHG A;  2WGP A;  2CM3 A;  3ZV2 A;  2I6I A;  3SR9 A;  5KA8 A;  3ZM6 A;  4NYH A;  1OES A;  1NWE A;  1OHC A;  1ZZW A;  3BRH A;  4DGP A;  2Q05 A;  1WAX A;  3F41 A;  2FJM A;  1XBO A;  1LAR A;  5HDE A;  3ZL8 A;  4D3R A;  2YDU A;  4R0S A;  2PQ5 A;  2CNF A;  1GFY A;  2OOQ A;  2QCT A;  4HRF A;  3QCI A;  3V0F A;  1ECV A;  1Q6J A;  4QAP A;  2JFF A;  4NND A;  2GC5 A;  3NME A;  2Q47 A;  2HVL A;  2QDP A;  2GJT A;  2CMB A;  2QDM A;  1OHE A;  1YPT A;  1P31 A;  3N0A A;  2NLK A;  2X5O A;  1PA1 A;  2F70 A;  4RKK A;  3OLR A;  1Q1M A;  3I36 A;  1XXV A;  3PYZ A;  5BX1 A;  4J51 A;  2H04 A;  1GWZ A;  5KAC A;  3EU0 A;  4GFV A;  2NT2 A;  2CNI A;  5M43 A;  1C86 A;  2PBN A;  4TVV A;  4R30 A;  2Y2F A;  5EHP A;  2F00 A;  2Y96 A;  4R0T A;  2PSZ A;  2CNE A;  4DGX A;  1R6H A;  3PS5 A;  4D3Q A;  1KAV A;  4ZN5 A;  1C85 A;  5MMZ B;  4GE6 A;  2FJN A;  1XM2 A;  2JFG A;  4OHD A;  3QCJ A;  2GCA A;  1T4J A;  3ZM3 A;  3V0H A;  1GG4 A;  3O5X A;  3LK7 A;  1YTN A;  2R0B A;  2VEY A;  3S3E A;  1E8C A;  1UAG A;  3N2A A;  4RH5 A;  5K23 A;  2VTE A;  5A5F A;  4RI5 A;  2P6X A;  4C13 A;  2VEV A;  5J8R A;  1VHR A;  4YAA A;  3GXH A;  4AZ1 A;  2NV5 A;  4PYH A;  1P15 A;  2HNQ A;  2CNG A;  4ZIY A;  2JFH A;  5KA7 A;  1ZCL A;  2H4V A;  4ZRT A;  1OEU A;  2Y68 A;  3ZMQ A;  2I6M A;  4IKC A;  2BV5 A;  3O4T A;  2I4G A;  4QAH A;  3V0G A;  1O5Z A;  2F46 A;  3A5K A;  2CM7 A;  3CWE A;  4NWF A;  2B3O A;  4OHH A;  4RI4 A;  1NWL A;  2HXP A;  3RZ2 A;  3EB1 A;  1I9T A;  3EZZ A;  4JMJ A;  2H03 A;  2I4H A;  1G4U S;  2QDC A;  1QXK A;  2HC1 A;  2VTD A;  4RDD A;  4WU3 A;  3AWG A;  4BUB A;  5KA0 A;  2F6W A;  3D44 A;  2WTZ A;  1NL9 A;  3QCB A;  4GRZ A;  3F9B A;  2BZL A;  3ZM5 A; 
#chains in the Genus database with same CATH homology
 1YGR A;  4QBE A;  2FH7 A;  4GRY A;  3O3L A;  2H02 A;  1G4W R;  3O4S A;  3QCH A;  2QBS A;  2ZMM A;  4ERC A;  4GS0 A;  2I3R A;  2J16 B;  4Y2E A;  4WTY A;  1OHD A;  1BZJ A;  1AAX A;  1T49 A;  2GWO A;  2A3K A;  3D1Q A;  5KA2 A;  1NO6 A;  3A5J A;  1XXP A;  3GXG A;  3F81 A;  1PH0 A;  2NZ6 A;  1XRI A;  4GE5 A;  2JJD A;  4OHE A;  1YZ4 A;  2VEU A;  1I57 A;  1LYV A;  3MOZ A;  1SUG A;  1QZ0 A;  3I7Z A;  2BGE A;  2HC2 A;  1C84 A;  1J4X A;  1U25 A;  1FPZ A;  2HY3 A;  5IBS A;  2H4K A;  5KA9 A;  1OEV A;  2F6Z A;  2VEW A;  3B7O A;  2CJZ A;  2G6Z A;  1OET A;  3QCC A;  5BZX A;  4B04 A;  3RGO A;  4GFU A;  3D1H A;  4HJP A;  2I5X A;  2QBR A;  1BZH A;  5K9W A;  1Q6S A;  3SME A;  4BJO A;  4YR8 B;  2CFV A;  2HCM A;  1V3A A;  3EMU A;  2F6V A;  4QUM A;  1ZC0 A;  5KA4 A;  3ZM0 A;  5BUG A;  2B4O A;  2I75 A;  2I42 A;  2OZ5 A;  4GE2 A;  3QKP A;  2E0T A;  1YWF A;  4BPC A;  3AWE A;  2AHS A;  2C7S A;  2NT7 A;  3D42 A;  3ZM1 A;  3RO1 A;  3QCD A;  4QBW A;  2B4S A;  3S3F A;  3MOW A;  5K25 A;  1Q6M A;  1OEM X;  2CM2 A;  3BLT A;  3O4U A;  5EHR A;  2HNP A;  1G7G A;  1X24 A;  2F71 A;  2GP0 A;  4WU2 A;  1ONY A;  2CMC A;  2F6Y A;  2OC3 A;  1YTS A;  1EEN A;  2NTA A;  3QCF A;  1NZ7 A;  1WCH A;  1Q6P A;  4NX8 A;  5K22 A;  3QCN A;  1EEO A;  2H4G A;  2QCJ A;  1G1F A;  3EAX A;  3ZMP A;  3AWF A;  3S4E A;  2SHP A;  4GWF A;  3ZM2 A;  4JBC A;  2BIJ A;  4H1O A;  2PI7 A;  3M4U A;  5I6V A;  5KA3 A;  1RXD A;  2J17 A;  2QEP A;  4KYR A;  2M3V A;  1D5R A;  2I3U A;  5KAA A;  5KAB A;  2BGD A;  1L8K A;  3QCL A;  5KA1 A;  1YTW A;  4NWG A;  1M3G A;  1PTV A;  4JNB A;  1OEO X;  2B49 A;  2AZR A;  1JLN A;  3S4O A;  1A5Y A;  1T48 A;  1C87 A;  1PXH A;  4MBB A;  3V0I A;  2DXP A;  4JMK A;  3V0E A;  1C83 A;  2B4P A;  1PTU A;  3F99 A;  4OHI A;  5AWX A;  2IMG A;  2P4D A;  2I4E A;  1Q6N A;  2PA5 A;  4ZI4 A;  3U96 A;  4S0G A;  2I6J A;  2C46 A;  3QCK A;  1C88 A;  2I6O A;  4KI9 A;  4PVG A;  3QCM A;  2QBQ A;  5LXQ B;  1I9S A;  1LQF A;  3QCE A;  1G1H A;  4H34 A;  4QUN A;  4KYQ A;  1JF7 A;  5GTJ A;  3I80 A;  1KAK A;  1Q6T A;  4ICZ A;  2QBP A;  1YGU A;  5KAD A;  3S3H A;  3H2X A;  2B07 A;  2RF6 A;  5BZZ A;  3D9C A;  1FQ1 A;  1L8G A;  2OUD A;  2VEX A;  3MMJ A;  1PTY A;  1G1G A;  1YN9 A;  4I8N A;  1U24 A;  4HJQ A;  2A8B A;  3S3K A;  4Y14 A;  2F6T A;  2ZN7 A;  1PA9 A;  1PTT A;  1PYN A;  1U26 A;  1WRM A;  2CM8 A;  3F9A A;  3QCG A;  2F6F A;  4OHL A;  5IBM A;  4Z6B A;  2HB1 A;  3V0J A;  1MKP A;  4RH9 A;  3OMH A;  4WOH A;  1FPR A;  3D1O A;  2I1Y A;  5K9V A;  2ESB A;  4D3P A;  1ONZ A;  3LJ8 A;  1YFO A;  3BM8 A;  2CMA A;  3RGQ A;  1ZCK A;  2MBC A;  2G59 A;  2J16 A;  2B4U A;  2PT0 A;  3V0D A;  3BLU A;  5K24 A;  3QKQ A;  1G7F A;  2CNH A;  2I6P A;  1RPM A;  3CM3 A;  1BZC A;  1NNY A;  4RHG A;  2WGP A;  2CM3 A;  3ZV2 A;  2I6I A;  3SR9 A;  5KA8 A;  4NYH A;  1OES A;  1NWE A;  1OHC A;  1ZZW A;  3BRH A;  4DGP A;  2Q05 A;  1WAX A;  3F41 A;  2FJM A;  1XBO A;  1LAR A;  5HDE A;  4D3R A;  2YDU A;  4R0S A;  2PQ5 A;  2CNF A;  1GFY A;  2OOQ A;  2QCT A;  4HRF A;  3QCI A;  3V0F A;  1ECV A;  1Q6J A;  4QAP A;  4NND A;  3NME A;  2Q47 A;  2HVL A;  2QDP A;  2GJT A;  2CMB A;  2QDM A;  1OHE A;  1YPT A;  3N0A A;  2NLK A;  1PA1 A;  2F70 A;  4RKK A;  3OLR A;  1Q1M A;  3I36 A;  1XXV A;  5BX1 A;  4J51 A;  2H04 A;  1GWZ A;  5KAC A;  3EU0 A;  4GFV A;  2NT2 A;  2CNI A;  5M43 A;  1C86 A;  2PBN A;  4TVV A;  4R30 A;  2Y2F A;  5EHP A;  2Y96 A;  4R0T A;  2PSZ A;  2CNE A;  4DGX A;  1R6H A;  3PS5 A;  4D3Q A;  1KAV A;  4ZN5 A;  1C85 A;  5MMZ B;  4GE6 A;  2FJN A;  1XM2 A;  4OHD A;  3QCJ A;  1T4J A;  3ZM3 A;  3V0H A;  3O5X A;  1YTN A;  2R0B A;  2VEY A;  3S3E A;  4RH5 A;  5K23 A;  4RI5 A;  2P6X A;  2VEV A;  5J8R A;  1VHR A;  4YAA A;  3GXH A;  4AZ1 A;  2NV5 A;  4PYH A;  1P15 A;  2HNQ A;  2CNG A;  5KA7 A;  1ZCL A;  2H4V A;  4ZRT A;  1OEU A;  3ZMQ A;  2I6M A;  4IKC A;  2BV5 A;  3O4T A;  2I4G A;  4QAH A;  3V0G A;  2F46 A;  3A5K A;  2CM7 A;  3CWE A;  4NWF A;  2B3O A;  4OHH A;  4RI4 A;  1NWL A;  2HXP A;  3RZ2 A;  3EB1 A;  1I9T A;  3EZZ A;  4JMJ A;  2H03 A;  2I4H A;  1G4U S;  2QDC A;  1QXK A;  2HC1 A;  4RDD A;  4WU3 A;  3AWG A;  5KA0 A;  2F6W A;  3D44 A;  1NL9 A;  3QCB A;  4GRZ A;  3F9B A;  2BZL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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