1G7FA

Human ptp1b catalytic domain complexed with pnu177496
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
297
structure length
297
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLDMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1
total genus 103
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2000-11-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 1g7fA00
4H1OA 1PXHA 3F41A 2VEXA 3F9AA 3SR9A 3ZMPA 3AWEA 1RXDA 5KABA 3QCBA 1EEOA 3QCHA 5MMZB 2HY3A 2BGDA 5BZZA 3B7OA 2F6WA 4ERCA 1L8GA 3D9CA 2PQ5A 3MOWA 3O4TA 4R0TA 2F6ZA 2H02A 3D1HA 4PVGA 5K9VA 3QKPA 4NWGA 2CMAA 1GFYA 1VHRA 1KAKA 1ZC0A 2H04A 1P15A 3S3KA 2CNHA 2I42A 2NT7A 2QCTA 3MMJA 5AWXA 2JJDA 3A5KA 2PI7A 3RO1A 1T48A 1XRIA 1G4US 2RF6A 3D44A 4NYHA 1SUGA 2BIJA 2CNIA 4PYHA 4WU2A 1Q6PA 4GE2A 3I36A 3F9BA 3SMEA 2VEUA 1M3GA 3O4UA 4J51A 4QUMA 1BZHA 3EZZA 2I75A 3A5JA 5K22A 2E0TA 2P4DA 1XXPA 2B4OA 2PA5A 1NWEA 2I3UA 4WTYA 1Q6NA 3ZM2A 1QXKA 2AHSA 3QCKA 1RPMA 4Z6BA 2CM7A 2NT2A 3O5XA 2I4GA 4NWFA 2PT0A 5KACA 2H4KA 3EU0A 3F81A 3PS5A 1FPZA 5BX1A 2I6JA 2I6IA 3ZV2A 4RI5A 2PSZA 3V0IA 5IBMA 1PYNA 3GXGA 3EAXA 4RI4A 4GE5A 5KA8A 2QCJA 4RH5A 1BZJA 3AWGA 2FJNA 2F70A 4GE6A 2F46A 3CWEA 2B4UA 4DGXA 5M43A 2B07A 3OLRA 2OOQA 3NMEA 1J4XA 4S0GA 2QDMA 1G1FA 5BUGA 1V3AA 2B4SA 2HB1A 3RGOA 2IMGA 1AAXA 1T4JA 3D42A 5K25A 2H4VA 2QDCA 1YTNA 5K9WA 2ZMMA 1YPTA 4ZRTA 1EENA 1ZCLA 2G59A 4HJQA 2C7SA 3V0EA 3OMHA 1Q6SA 2QBPA 1Q6TA 4QAPA 1OHDA 5KA3A 1NL9A 4H34A 2OC3A 4GRYA 1LARA 1XBOA 4BPCA 5KAAA 2QBSA 4WOHA 4JMJA 4RHGA 1YTSA 3QCEA 3F99A 5EHRA 1G1GA 4OHDA 3QCDA 2H4GA 2HNQA 1MKPA 4OHIA 1I57A 1OEVA 1PH0A 3N0AA 3QCJA 5KA2A 4RKKA 1YN9A 4ZI4A 2G6ZA 1PA9A 4Y2EA 2AZRA 2NV5A 1Q6JA 4JBCA 4D3QA 5KA4A 1NO6A 4WU3A 2CMCA 4YAAA 3V0DA 3ZMQA 1JF7A 2Q05A 5GTJA 1T49A 1YGRA 4D3RA 4ZN5A 3M4UA 1ECVA 2B49A 2QEPA 2R0BA 2I6PA 3AWFA 1YGUA 2I4HA 2A3KA 3V0HA 3QCFA 2FH7A 4OHLA 3QKQA 2A8BA 3GXHA 5KA1A 1OESA 4I8NA 3ZM0A 4GFUA 2OZ5A 3BRHA 3I7ZA 3RGQA 1KAVA 1XXVA 3MOZA 1NNYA 2HNPA 2B4PA 1PTVA 3QCCA 4RDDA 2H03A 1LYVA 2GP0A 1G1HA 4TVVA 5J8RA 2CNFA 1OEMX 1OETA 1D5RA 1YWFA 5KA9A 1ONYA 4HJPA 3EMUA 2Y96A 1R6HA 3O4SA 2J16B 4GRZA 1BZCA 3BLUA 4R0SA 2J16A 5KA7A 2P6XA 2VEWA 5KADA 1YTWA 2MBCA 3H2XA 4JNBA 1X24A 1OEUA 2DXPA 2HXPA 1OHCA 1Q6MA 4QBWA 3D1OA 3I80A 4D3PA 2Y2FA 3V0GA 4QAHA 4GS0A 2HCMA 1XM2A 2CMBA 2VEYA 3QCLA 5K24A 5I6VA 3CM3A 5HDEA 3S3FA 3BM8A 5KA0A 3QCMA 4OHEA 2QBRA 2CM2A 2CJZA 3QCIA 2QDPA 2I4EA 3S3HA 1G7GA 2NLKA 1U25A 4R30A 4JMKA 4NX8A 3V0JA 4QBEA 5K23A 1Q1MA 4OHHA 1PTYA 2F71A 3O3LA 3ZM1A 2I6OA 1C86A 3QCNA 4KI9A 4DGPA 2I6MA 1YZ4A 3S4OA 4NNDA 3V0FA 3LJ8A 3D1QA 2BGEA 1A5YA 2I1YA 2GJTA 2I5XA 4KYQA 1JLNA 2B3OA 1C84A 2NZ6A 2BV5A 1OEOX 4B04A 1WCHA 1ZCKA 1C88A 1U26A 1U24A 3S4EA 1ONZA 1PTUA 2F6YA 2SHPA 2YDUA 1WAXA 1PA1A 2NTAA 1QZ0A 1GWZA 1C87A 2CM3A 1I9TA 1ZZWA 2FJMA 2HVLA 3BLTA 3S3EA 1I9SA 2BZLA 2QBQA 4RH9A 4YR8B 4GFVA 2F6FA 2J17A 5EHPA 2I3RA 1FQ1A 2CFVA 1WRMA 2OUDA 1C85A 2M3VA 3RZ2A 2CM8A 3EB1A 5IBSA 2F6TA 2GWOA 1OHEA 4QUNA 1YFOA 4KYRA 5BZXA 1LQFA 4GWFA 4BJOA 2CNGA 3QCGA 1FPRA 1NWLA 1L8KA 2ESBA 3ZM3A 3U96A 2VEVA 1PTTA 4HRFA 5LXQB 2Q47A 2F6VA 2CNEA 4IKCA 1NZ7A 2WGPA 1C83A 2PBNA 2HC1A 1G4WR 4MBBA 4AZ1A 2HC2A 4ICZA 2ZN7A 4Y14A 1G7FA 2C46A
chains in the Genus database with same CATH superfamily
4H1OA 1PXHA 3F41A 2VEXA 3F9AA 3SR9A 3ZMPA 3AWEA 1RXDA 5KABA 3N2AA 3QCBA 1EEOA 3QCHA 5MMZB 2HY3A 2BGDA 5BZZA 3B7OA 2F6WA 4ERCA 1FGSA 1L8GA 3D9CA 3MVNA 2PQ5A 1JBWA 3MOWA 3O4TA 4R0TA 2F6ZA 2GC5A 2H02A 2XPCA 3D1HA 4PVGA 5K9VA 2VORA 3QKPA 4NWGA 2CMAA 1GQQA 1GFYA 1VHRA 1KAKA 1ZC0A 2H04A 1P15A 3S3KA 2CNHA 2I42A 2NT7A 2QCTA 3MMJA 5AWXA 2JJDA 3A5KA 2PI7A 3RO1A 1T48A 1XRIA 1G4US 2RF6A 3D44A 4NYHA 4C13A 1SUGA 2BIJA 2CNIA 4PYHA 4WU2A 3PYZA 1Q6PA 4GE2A 1EEHA 3I36A 3F9BA 3SMEA 2VEUA 1M3GA 3O4UA 4J51A 4QUMA 1BZHA 3EZZA 2I75A 3A5JA 5K22A 2E0TA 2P4DA 1XXPA 2B4OA 2PA5A 1NWEA 2I3UA 4WTYA 1Q6NA 3ZM2A 1QXKA 2AHSA 3QCKA 1RPMA 4Z6BA 2CM7A 2NT2A 3O5XA 2I4GA 4NWFA 2PT0A 5KACA 2H4KA 3EU0A 3F81A 3PS5A 1FPZA 2F00A 5BX1A 2I6JA 4HV4A 2I6IA 3ZV2A 4RI5A 2PSZA 3V0IA 5IBMA 1PYNA 3GXGA 4CVLA 3EAXA 4RI4A 4GE5A 5KA8A 2QCJA 4RH5A 1BZJA 3AWGA 2FJNA 2F70A 4GE6A 2F46A 3CWEA 2B4UA 4DGXA 5M43A 3ZL8A 2B07A 2XJAA 3OLRA 2OOQA 3NMEA 1J4XA 4S0GA 2QDMA 1G1FA 5BUGA 1V3AA 2B4SA 2HB1A 3RGOA 2IMGA 1AAXA 1W78A 1T4JA 3D42A 5K25A 2H4VA 2QDCA 1YTNA 5K9WA 2ZMMA 1YPTA 4ZRTA 4ZIYA 1EENA 1ZCLA 1UAGA 2G59A 4HJQA 2C7SA 2JFGA 3V0EA 2Y1OA 1Q6SA 2QBPA 1Q6TA 3OMHA 4QAPA 1OHDA 5KA3A 1NL9A 4H34A 2OC3A 4GRYA 1LARA 1XBOA 4BPCA 5KAAA 2QBSA 4WOHA 4JMJA 2AM2A 4RHGA 1YTSA 3QCEA 3F99A 5EHRA 1G1GA 4OHDA 3QCDA 2H4GA 2HNQA 1MKPA 4OHIA 1PH0A 1I57A 1OEVA 2JFHA 3N0AA 3QCJA 5KA2A 5A5FA 4RKKA 1YN9A 1GG4A 4ZI4A 2G6ZA 1PA9A 4Y2EA 2AZRA 2NV5A 1Q6JA 4JBCA 4D3QA 5KA4A 1NO6A 4WU3A 2CMCA 4YAAA 3V0DA 3ZMQA 1JF7A 2Q05A 5GTJA 1T49A 1YGRA 4D3RA 4ZN5A 3M4UA 3LK7A 1ECVA 2B49A 2QEPA 2R0BA 2I6PA 3AWFA 1YGUA 4C12A 2I4HA 2A3KA 3V0HA 3QCFA 2FH7A 4OHLA 3QKQA 2A8BA 3GXHA 2UUPA 5KA1A 1OESA 4I8NA 3ZM0A 4GFUA 2OZ5A 3BRHA 3I7ZA 3RGQA 1KAVA 1XXVA 3MOZA 1NNYA 2HNPA 2B4PA 1PTVA 1P3DA 3QCCA 3QCZA 2VOSA 2H03A 1LYVA 2GP0A 1G1HA 4RDDA 4TVVA 5J8RA 2CNFA 1OEMX 1OETA 2AM1A 1D5RA 1YWFA 5KA9A 1ONYA 3NRSA 4HJPA 3EMUA 2Y96A 1R6HA 2VTDA 3O4SA 2J16B 4GRZA 1BZCA 3BLUA 2Y67A 4R0SA 2J16A 5KA7A 2P6XA 2VEWA 5KADA 1YTWA 2MBCA 3H2XA 4JNBA 1O5ZA 1X24A 1OEUA 2DXPA 2HXPA 1OHCA 1Q6MA 4QBWA 3D1OA 3I80A 4D3PA 2Y2FA 3V0GA 4QAHA 3ZM6A 4GS0A 2HCMA 1XM2A 2CMBA 2VEYA 3QCLA 5K24A 5I6VA 3CM3A 5HDEA 3S3FA 3UAGA 3BM8A 5KA0A 3QCMA 4OHEA 2QBRA 2CM2A 2CJZA 3QCIA 2QDPA 2I4EA 3S3HA 1G7GA 2NLKA 1U25A 4R30A 4JMKA 4NX8A 3V0JA 4QBEA 5K23A 1E0DA 1Q1MA 4OHHA 1PTYA 2F71A 3O3LA 3ZM1A 2I6OA 2Y66A 1C86A 3QCNA 2UAGA 4KI9A 3ZM5A 4DGPA 4BUCA 4BUBA 2I6MA 1YZ4A 3S4OA 4NNDA 3V0FA 3LJ8A 3HN7A 2JFFA 3D1QA 2BGEA 1A5YA 2I1YA 2GJTA 2I5XA 4KYQA 1JLNA 2B3OA 1C84A 2NZ6A 2BV5A 1OEOX 4B04A 1WCHA 1ZCKA 1C88A 1U26A 1U24A 2VTEA 3S4EA 1ONZA 1PTUA 2F6YA 2SHPA 2WTZA 2YDUA 1W7KA 1WAXA 1PA1A 2NTAA 1QZ0A 2GCBA 1GWZA 1C87A 2CM3A 1JBVA 1I9TA 1ZZWA 1E8CA 2FJMA 2WJPA 4CVKA 2HVLA 3BLTA 3S3EA 1I9SA 2BZLA 2QBQA 4RH9A 4YR8B 2GC6A 4GFVA 1J6UA 2F6FA 2J17A 5EHPA 2I3RA 1FQ1A 2CFVA 1WRMA 2OUDA 4QDIA 1C85A 2M3VA 4QF5A 3RZ2A 2CM8A 3EB1A 5IBSA 2F6TA 2GWOA 4CVMA 1OHEA 4QUNA 4UAGA 1YFOA 4KYRA 2Y68A 5BZXA 1LQFA 4GWFA 4BJOA 2CNGA 3QCGA 5A5EA 2X5OA 1FPRA 1NWLA 1L8KA 2ESBA 3ZM3A 3U96A 2VEVA 1PTTA 4HRFA 5LXQB 1GQYA 1P31A 2Q47A 2F6VA 2CNEA 4IKCA 1NZ7A 2WGPA 1C83A 2PBNA 2HC1A 1G4WR 4MBBA 2UUOA 2GCAA 4AZ1A 2HC2A 4ICZA 2ZN7A 4Y14A 1G7FA 2C46A
chains in the Genus database with same CATH topology
4H1OA 1PXHA 3F41A 2VEXA 3F9AA 3SR9A 3ZMPA 3AWEA 1RXDA 5KABA 3QCBA 1EEOA 3QCHA 5MMZB 2HY3A 2BGDA 5BZZA 3B7OA 2F6WA 4ERCA 1L8GA 3D9CA 2PQ5A 3MOWA 3O4TA 4R0TA 2F6ZA 2H02A 3D1HA 4PVGA 5K9VA 3QKPA 4NWGA 2CMAA 1GFYA 1VHRA 1KAKA 1ZC0A 2H04A 1P15A 3S3KA 2CNHA 2I42A 2NT7A 2QCTA 3MMJA 5AWXA 2JJDA 3A5KA 2PI7A 3RO1A 1T48A 1XRIA 1G4US 2RF6A 3D44A 4NYHA 1SUGA 2BIJA 2CNIA 4PYHA 4WU2A 1Q6PA 4GE2A 3I36A 3F9BA 3SMEA 2VEUA 1M3GA 3O4UA 4J51A 4QUMA 1BZHA 3EZZA 2I75A 3A5JA 5K22A 2E0TA 2P4DA 1XXPA 2B4OA 2PA5A 1NWEA 2I3UA 4WTYA 1Q6NA 3ZM2A 1QXKA 2AHSA 3QCKA 1RPMA 4Z6BA 2CM7A 2NT2A 3O5XA 2I4GA 4NWFA 2PT0A 5KACA 2H4KA 3EU0A 3F81A 3PS5A 1FPZA 5BX1A 2I6JA 2I6IA 3ZV2A 4RI5A 2PSZA 3V0IA 5IBMA 1PYNA 3GXGA 3EAXA 4RI4A 4GE5A 5KA8A 2QCJA 4RH5A 1BZJA 3AWGA 2FJNA 2F70A 4GE6A 2F46A 3CWEA 2B4UA 4DGXA 5M43A 2B07A 3OLRA 2OOQA 3NMEA 1J4XA 4S0GA 2QDMA 1G1FA 5BUGA 1V3AA 2B4SA 2HB1A 3RGOA 2IMGA 1AAXA 1T4JA 3D42A 5K25A 2H4VA 2QDCA 1YTNA 5K9WA 2ZMMA 1YPTA 4ZRTA 1EENA 1ZCLA 2G59A 4HJQA 2C7SA 3V0EA 3OMHA 1Q6SA 2QBPA 1Q6TA 4QAPA 1OHDA 5KA3A 1NL9A 4H34A 2OC3A 4GRYA 1LARA 1XBOA 4BPCA 5KAAA 2QBSA 4WOHA 4JMJA 4RHGA 1YTSA 3QCEA 3F99A 5EHRA 1G1GA 4OHDA 3QCDA 2H4GA 2HNQA 1MKPA 4OHIA 1I57A 1OEVA 1PH0A 3N0AA 3QCJA 5KA2A 4RKKA 1YN9A 4ZI4A 2G6ZA 1PA9A 4Y2EA 2AZRA 2NV5A 1Q6JA 4JBCA 4D3QA 5KA4A 1NO6A 4WU3A 2CMCA 4YAAA 3V0DA 3ZMQA 1JF7A 2Q05A 5GTJA 1T49A 1YGRA 4D3RA 4ZN5A 3M4UA 1ECVA 2B49A 2QEPA 2R0BA 2I6PA 3AWFA 1YGUA 2I4HA 2A3KA 3V0HA 3QCFA 2FH7A 4OHLA 3QKQA 2A8BA 3GXHA 5KA1A 1OESA 4I8NA 3ZM0A 4GFUA 2OZ5A 3BRHA 3I7ZA 3RGQA 1KAVA 1XXVA 3MOZA 1NNYA 2HNPA 2B4PA 1PTVA 3QCCA 4RDDA 2H03A 1LYVA 2GP0A 1G1HA 4TVVA 5J8RA 2CNFA 1OEMX 1OETA 1D5RA 1YWFA 5KA9A 1ONYA 4HJPA 3EMUA 2Y96A 1R6HA 3O4SA 2J16B 4GRZA 1BZCA 3BLUA 4R0SA 2J16A 5KA7A 2P6XA 2VEWA 5KADA 1YTWA 2MBCA 3H2XA 4JNBA 1X24A 1OEUA 2DXPA 2HXPA 1OHCA 1Q6MA 4QBWA 3D1OA 3I80A 4D3PA 2Y2FA 3V0GA 4QAHA 4GS0A 2HCMA 1XM2A 2CMBA 2VEYA 3QCLA 5K24A 5I6VA 3CM3A 5HDEA 3S3FA 3BM8A 5KA0A 3QCMA 4OHEA 2QBRA 2CM2A 2CJZA 3QCIA 2QDPA 2I4EA 3S3HA 1G7GA 2NLKA 1U25A 4R30A 4JMKA 4NX8A 3V0JA 4QBEA 5K23A 1Q1MA 4OHHA 1PTYA 2F71A 3O3LA 3ZM1A 2I6OA 1C86A 3QCNA 4KI9A 4DGPA 2I6MA 1YZ4A 3S4OA 4NNDA 3V0FA 3LJ8A 3D1QA 2BGEA 1A5YA 2I1YA 2GJTA 2I5XA 4KYQA 1JLNA 2B3OA 1C84A 2NZ6A 2BV5A 1OEOX 4B04A 1WCHA 1ZCKA 1C88A 1U26A 1U24A 3S4EA 1ONZA 1PTUA 2F6YA 2SHPA 2YDUA 1WAXA 1PA1A 2NTAA 1QZ0A 1GWZA 1C87A 2CM3A 1I9TA 1ZZWA 2FJMA 2HVLA 3BLTA 3S3EA 1I9SA 2BZLA 2QBQA 4RH9A 4YR8B 4GFVA 2F6FA 2J17A 5EHPA 2I3RA 1FQ1A 2CFVA 1WRMA 2OUDA 1C85A 2M3VA 3RZ2A 2CM8A 3EB1A 5IBSA 2F6TA 2GWOA 1OHEA 4QUNA 1YFOA 4KYRA 5BZXA 1LQFA 4GWFA 4BJOA 2CNGA 3QCGA 1FPRA 1NWLA 1L8KA 2ESBA 3ZM3A 3U96A 2VEVA 1PTTA 4HRFA 5LXQB 2Q47A 2F6VA 2CNEA 4IKCA 1NZ7A 2WGPA 1C83A 2PBNA 2HC1A 1G4WR 4MBBA 4AZ1A 2HC2A 4ICZA 2ZN7A 4Y14A 1G7FA 2C46A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H1O A;  1PXH A;  3F41 A;  2VEX A;  3F9A A;  3SR9 A;  3ZMP A;  3AWE A;  1RXD A;  5KAB A;  3QCB A;  1EEO A;  3QCH A;  5MMZ B;  2HY3 A;  2BGD A;  5BZZ A;  3B7O A;  2F6W A;  4ERC A;  1L8G A;  3D9C A;  2PQ5 A;  3MOW A;  3O4T A;  4R0T A;  2F6Z A;  2H02 A;  3D1H A;  4PVG A;  5K9V A;  3QKP A;  4NWG A;  2CMA A;  1GFY A;  1VHR A;  1KAK A;  1ZC0 A;  2H04 A;  1P15 A;  3S3K A;  2CNH A;  2I42 A;  2NT7 A;  2QCT A;  3MMJ A;  5AWX A;  2JJD A;  3A5K A;  2PI7 A;  3RO1 A;  1T48 A;  1XRI A;  1G4U S;  2RF6 A;  3D44 A;  4NYH A;  1SUG A;  2BIJ A;  2CNI A;  4PYH A;  4WU2 A;  1Q6P A;  4GE2 A;  3I36 A;  3F9B A;  3SME A;  2VEU A;  1M3G A;  3O4U A;  4J51 A;  4QUM A;  1BZH A;  3EZZ A;  2I75 A;  3A5J A;  5K22 A;  2E0T A;  2P4D A;  1XXP A;  2B4O A;  2PA5 A;  1NWE A;  2I3U A;  4WTY A;  1Q6N A;  3ZM2 A;  1QXK A;  2AHS A;  3QCK A;  1RPM A;  4Z6B A;  2CM7 A;  2NT2 A;  3O5X A;  2I4G A;  4NWF A;  2PT0 A;  5KAC A;  2H4K A;  3EU0 A;  3F81 A;  3PS5 A;  1FPZ A;  5BX1 A;  2I6J A;  2I6I A;  3ZV2 A;  4RI5 A;  2PSZ A;  3V0I A;  5IBM A;  1PYN A;  3GXG A;  3EAX A;  4RI4 A;  4GE5 A;  5KA8 A;  2QCJ A;  4RH5 A;  1BZJ A;  3AWG A;  2FJN A;  2F70 A;  4GE6 A;  2F46 A;  3CWE A;  2B4U A;  4DGX A;  5M43 A;  2B07 A;  3OLR A;  2OOQ A;  3NME A;  1J4X A;  4S0G A;  2QDM A;  1G1F A;  5BUG A;  1V3A A;  2B4S A;  2HB1 A;  3RGO A;  2IMG A;  1AAX A;  1T4J A;  3D42 A;  5K25 A;  2H4V A;  2QDC A;  1YTN A;  5K9W A;  2ZMM A;  1YPT A;  4ZRT A;  1EEN A;  1ZCL A;  2G59 A;  4HJQ A;  2C7S A;  3V0E A;  3OMH A;  1Q6S A;  2QBP A;  1Q6T A;  4QAP A;  1OHD A;  5KA3 A;  1NL9 A;  4H34 A;  2OC3 A;  4GRY A;  1LAR A;  1XBO A;  4BPC A;  5KAA A;  2QBS A;  4WOH A;  4JMJ A;  4RHG A;  1YTS A;  3QCE A;  3F99 A;  5EHR A;  1G1G A;  4OHD A;  3QCD A;  2H4G A;  2HNQ A;  1MKP A;  4OHI A;  1I57 A;  1OEV A;  1PH0 A;  3N0A A;  3QCJ A;  5KA2 A;  4RKK A;  1YN9 A;  4ZI4 A;  2G6Z A;  1PA9 A;  4Y2E A;  2AZR A;  2NV5 A;  1Q6J A;  4JBC A;  4D3Q A;  5KA4 A;  1NO6 A;  4WU3 A;  2CMC A;  4YAA A;  3V0D A;  3ZMQ A;  1JF7 A;  2Q05 A;  5GTJ A;  1T49 A;  1YGR A;  4D3R A;  4ZN5 A;  3M4U A;  1ECV A;  2B49 A;  2QEP A;  2R0B A;  2I6P A;  3AWF A;  1YGU A;  2I4H A;  2A3K A;  3V0H A;  3QCF A;  2FH7 A;  4OHL A;  3QKQ A;  2A8B A;  3GXH A;  5KA1 A;  1OES A;  4I8N A;  3ZM0 A;  4GFU A;  2OZ5 A;  3BRH A;  3I7Z A;  3RGQ A;  1KAV A;  1XXV A;  3MOZ A;  1NNY A;  2HNP A;  2B4P A;  1PTV A;  3QCC A;  4RDD A;  2H03 A;  1LYV A;  2GP0 A;  1G1H A;  4TVV A;  5J8R A;  2CNF A;  1OEM X;  1OET A;  1D5R A;  1YWF A;  5KA9 A;  1ONY A;  4HJP A;  3EMU A;  2Y96 A;  1R6H A;  3O4S A;  2J16 B;  4GRZ A;  1BZC A;  3BLU A;  4R0S A;  2J16 A;  5KA7 A;  2P6X A;  2VEW A;  5KAD A;  1YTW A;  2MBC A;  3H2X A;  4JNB A;  1X24 A;  1OEU A;  2DXP A;  2HXP A;  1OHC A;  1Q6M A;  4QBW A;  3D1O A;  3I80 A;  4D3P A;  2Y2F A;  3V0G A;  4QAH A;  4GS0 A;  2HCM A;  1XM2 A;  2CMB A;  2VEY A;  3QCL A;  5K24 A;  5I6V A;  3CM3 A;  5HDE A;  3S3F A;  3BM8 A;  5KA0 A;  3QCM A;  4OHE A;  2QBR A;  2CM2 A;  2CJZ A;  3QCI A;  2QDP A;  2I4E A;  3S3H A;  1G7G A;  2NLK A;  1U25 A;  4R30 A;  4JMK A;  4NX8 A;  3V0J A;  4QBE A;  5K23 A;  1Q1M A;  4OHH A;  1PTY A;  2F71 A;  3O3L A;  3ZM1 A;  2I6O A;  1C86 A;  3QCN A;  4KI9 A;  4DGP A;  2I6M A;  1YZ4 A;  3S4O A;  4NND A;  3V0F A;  3LJ8 A;  3D1Q A;  2BGE A;  1A5Y A;  2I1Y A;  2GJT A;  2I5X A;  4KYQ A;  1JLN A;  2B3O A;  1C84 A;  2NZ6 A;  2BV5 A;  1OEO X;  4B04 A;  1WCH A;  1ZCK A;  1C88 A;  1U26 A;  1U24 A;  3S4E A;  1ONZ A;  1PTU A;  2F6Y A;  2SHP A;  2YDU A;  1WAX A;  1PA1 A;  2NTA A;  1QZ0 A;  1GWZ A;  1C87 A;  2CM3 A;  1I9T A;  1ZZW A;  2FJM A;  2HVL A;  3BLT A;  3S3E A;  1I9S A;  2BZL A;  2QBQ A;  4RH9 A;  4YR8 B;  4GFV A;  2F6F A;  2J17 A;  5EHP A;  2I3R A;  1FQ1 A;  2CFV A;  1WRM A;  2OUD A;  1C85 A;  2M3V A;  3RZ2 A;  2CM8 A;  3EB1 A;  5IBS A;  2F6T A;  2GWO A;  1OHE A;  4QUN A;  1YFO A;  4KYR A;  5BZX A;  1LQF A;  4GWF A;  4BJO A;  2CNG A;  3QCG A;  1FPR A;  1NWL A;  1L8K A;  2ESB A;  3ZM3 A;  3U96 A;  2VEV A;  1PTT A;  4HRF A;  5LXQ B;  2Q47 A;  2F6V A;  2CNE A;  4IKC A;  1NZ7 A;  2WGP A;  1C83 A;  2PBN A;  2HC1 A;  1G4W R;  4MBB A;  4AZ1 A;  2HC2 A;  4ICZ A;  2ZN7 A;  4Y14 A;  1G7F A;  2C46 A; 
#chains in the Genus database with same CATH topology
 4H1O A;  1PXH A;  3F41 A;  2VEX A;  3F9A A;  3SR9 A;  3ZMP A;  3AWE A;  1RXD A;  5KAB A;  3N2A A;  3QCB A;  1EEO A;  3QCH A;  5MMZ B;  2HY3 A;  2BGD A;  5BZZ A;  3B7O A;  2F6W A;  4ERC A;  1FGS A;  1L8G A;  3D9C A;  3MVN A;  2PQ5 A;  1JBW A;  3MOW A;  3O4T A;  4R0T A;  2F6Z A;  2GC5 A;  2H02 A;  2XPC A;  3D1H A;  4PVG A;  5K9V A;  2VOR A;  3QKP A;  4NWG A;  2CMA A;  1GQQ A;  1GFY A;  1VHR A;  1KAK A;  1ZC0 A;  2H04 A;  1P15 A;  3S3K A;  2CNH A;  2I42 A;  2NT7 A;  2QCT A;  3MMJ A;  5AWX A;  2JJD A;  3A5K A;  2PI7 A;  3RO1 A;  1T48 A;  1XRI A;  1G4U S;  2RF6 A;  3D44 A;  4NYH A;  4C13 A;  1SUG A;  2BIJ A;  2CNI A;  4PYH A;  4WU2 A;  3PYZ A;  1Q6P A;  4GE2 A;  1EEH A;  3I36 A;  3F9B A;  3SME A;  2VEU A;  1M3G A;  3O4U A;  4J51 A;  4QUM A;  1BZH A;  3EZZ A;  2I75 A;  3A5J A;  5K22 A;  2E0T A;  2P4D A;  1XXP A;  2B4O A;  2PA5 A;  1NWE A;  2I3U A;  4WTY A;  1Q6N A;  3ZM2 A;  1QXK A;  2AHS A;  3QCK A;  1RPM A;  4Z6B A;  2CM7 A;  2NT2 A;  3O5X A;  2I4G A;  4NWF A;  2PT0 A;  5KAC A;  2H4K A;  3EU0 A;  3F81 A;  3PS5 A;  1FPZ A;  2F00 A;  5BX1 A;  2I6J A;  4HV4 A;  2I6I A;  3ZV2 A;  4RI5 A;  2PSZ A;  3V0I A;  5IBM A;  1PYN A;  3GXG A;  4CVL A;  3EAX A;  4RI4 A;  4GE5 A;  5KA8 A;  2QCJ A;  4RH5 A;  1BZJ A;  3AWG A;  2FJN A;  2F70 A;  4GE6 A;  2F46 A;  3CWE A;  2B4U A;  4DGX A;  5M43 A;  3ZL8 A;  2B07 A;  2XJA A;  3OLR A;  2OOQ A;  3NME A;  1J4X A;  4S0G A;  2QDM A;  1G1F A;  5BUG A;  1V3A A;  2B4S A;  2HB1 A;  3RGO A;  2IMG A;  1AAX A;  1W78 A;  1T4J A;  3D42 A;  5K25 A;  2H4V A;  2QDC A;  1YTN A;  5K9W A;  2ZMM A;  1YPT A;  4ZRT A;  4ZIY A;  1EEN A;  1ZCL A;  1UAG A;  2G59 A;  4HJQ A;  2C7S A;  2JFG A;  3V0E A;  2Y1O A;  1Q6S A;  2QBP A;  1Q6T A;  3OMH A;  4QAP A;  1OHD A;  5KA3 A;  1NL9 A;  4H34 A;  2OC3 A;  4GRY A;  1LAR A;  1XBO A;  4BPC A;  5KAA A;  2QBS A;  4WOH A;  4JMJ A;  2AM2 A;  4RHG A;  1YTS A;  3QCE A;  3F99 A;  5EHR A;  1G1G A;  4OHD A;  3QCD A;  2H4G A;  2HNQ A;  1MKP A;  4OHI A;  1PH0 A;  1I57 A;  1OEV A;  2JFH A;  3N0A A;  3QCJ A;  5KA2 A;  5A5F A;  4RKK A;  1YN9 A;  1GG4 A;  4ZI4 A;  2G6Z A;  1PA9 A;  4Y2E A;  2AZR A;  2NV5 A;  1Q6J A;  4JBC A;  4D3Q A;  5KA4 A;  1NO6 A;  4WU3 A;  2CMC A;  4YAA A;  3V0D A;  3ZMQ A;  1JF7 A;  2Q05 A;  5GTJ A;  1T49 A;  1YGR A;  4D3R A;  4ZN5 A;  3M4U A;  3LK7 A;  1ECV A;  2B49 A;  2QEP A;  2R0B A;  2I6P A;  3AWF A;  1YGU A;  4C12 A;  2I4H A;  2A3K A;  3V0H A;  3QCF A;  2FH7 A;  4OHL A;  3QKQ A;  2A8B A;  3GXH A;  2UUP A;  5KA1 A;  1OES A;  4I8N A;  3ZM0 A;  4GFU A;  2OZ5 A;  3BRH A;  3I7Z A;  3RGQ A;  1KAV A;  1XXV A;  3MOZ A;  1NNY A;  2HNP A;  2B4P A;  1PTV A;  1P3D A;  3QCC A;  3QCZ A;  2VOS A;  2H03 A;  1LYV A;  2GP0 A;  1G1H A;  4RDD A;  4TVV A;  5J8R A;  2CNF A;  1OEM X;  1OET A;  2AM1 A;  1D5R A;  1YWF A;  5KA9 A;  1ONY A;  3NRS A;  4HJP A;  3EMU A;  2Y96 A;  1R6H A;  2VTD A;  3O4S A;  2J16 B;  4GRZ A;  1BZC A;  3BLU A;  2Y67 A;  4R0S A;  2J16 A;  5KA7 A;  2P6X A;  2VEW A;  5KAD A;  1YTW A;  2MBC A;  3H2X A;  4JNB A;  1O5Z A;  1X24 A;  1OEU A;  2DXP A;  2HXP A;  1OHC A;  1Q6M A;  4QBW A;  3D1O A;  3I80 A;  4D3P A;  2Y2F A;  3V0G A;  4QAH A;  3ZM6 A;  4GS0 A;  2HCM A;  1XM2 A;  2CMB A;  2VEY A;  3QCL A;  5K24 A;  5I6V A;  3CM3 A;  5HDE A;  3S3F A;  3UAG A;  3BM8 A;  5KA0 A;  3QCM A;  4OHE A;  2QBR A;  2CM2 A;  2CJZ A;  3QCI A;  2QDP A;  2I4E A;  3S3H A;  1G7G A;  2NLK A;  1U25 A;  4R30 A;  4JMK A;  4NX8 A;  3V0J A;  4QBE A;  5K23 A;  1E0D A;  1Q1M A;  4OHH A;  1PTY A;  2F71 A;  3O3L A;  3ZM1 A;  2I6O A;  2Y66 A;  1C86 A;  3QCN A;  2UAG A;  4KI9 A;  3ZM5 A;  4DGP A;  4BUC A;  4BUB A;  2I6M A;  1YZ4 A;  3S4O A;  4NND A;  3V0F A;  3LJ8 A;  3HN7 A;  2JFF A;  3D1Q A;  2BGE A;  1A5Y A;  2I1Y A;  2GJT A;  2I5X A;  4KYQ A;  1JLN A;  2B3O A;  1C84 A;  2NZ6 A;  2BV5 A;  1OEO X;  4B04 A;  1WCH A;  1ZCK A;  1C88 A;  1U26 A;  1U24 A;  2VTE A;  3S4E A;  1ONZ A;  1PTU A;  2F6Y A;  2SHP A;  2WTZ A;  2YDU A;  1W7K A;  1WAX A;  1PA1 A;  2NTA A;  1QZ0 A;  2GCB A;  1GWZ A;  1C87 A;  2CM3 A;  1JBV A;  1I9T A;  1ZZW A;  1E8C A;  2FJM A;  2WJP A;  4CVK A;  2HVL A;  3BLT A;  3S3E A;  1I9S A;  2BZL A;  2QBQ A;  4RH9 A;  4YR8 B;  2GC6 A;  4GFV A;  1J6U A;  2F6F A;  2J17 A;  5EHP A;  2I3R A;  1FQ1 A;  2CFV A;  1WRM A;  2OUD A;  4QDI A;  1C85 A;  2M3V A;  4QF5 A;  3RZ2 A;  2CM8 A;  3EB1 A;  5IBS A;  2F6T A;  2GWO A;  4CVM A;  1OHE A;  4QUN A;  4UAG A;  1YFO A;  4KYR A;  2Y68 A;  5BZX A;  1LQF A;  4GWF A;  4BJO A;  2CNG A;  3QCG A;  5A5E A;  2X5O A;  1FPR A;  1NWL A;  1L8K A;  2ESB A;  3ZM3 A;  3U96 A;  2VEV A;  1PTT A;  4HRF A;  5LXQ B;  1GQY A;  1P31 A;  2Q47 A;  2F6V A;  2CNE A;  4IKC A;  1NZ7 A;  2WGP A;  1C83 A;  2PBN A;  2HC1 A;  1G4W R;  4MBB A;  2UUO A;  2GCA A;  4AZ1 A;  2HC2 A;  4ICZ A;  2ZN7 A;  4Y14 A;  1G7F A;  2C46 A; 
#chains in the Genus database with same CATH homology
 4H1O A;  1PXH A;  3F41 A;  2VEX A;  3F9A A;  3SR9 A;  3ZMP A;  3AWE A;  1RXD A;  5KAB A;  3QCB A;  1EEO A;  3QCH A;  5MMZ B;  2HY3 A;  2BGD A;  5BZZ A;  3B7O A;  2F6W A;  4ERC A;  1L8G A;  3D9C A;  2PQ5 A;  3MOW A;  3O4T A;  4R0T A;  2F6Z A;  2H02 A;  3D1H A;  4PVG A;  5K9V A;  3QKP A;  4NWG A;  2CMA A;  1GFY A;  1VHR A;  1KAK A;  1ZC0 A;  2H04 A;  1P15 A;  3S3K A;  2CNH A;  2I42 A;  2NT7 A;  2QCT A;  3MMJ A;  5AWX A;  2JJD A;  3A5K A;  2PI7 A;  3RO1 A;  1T48 A;  1XRI A;  1G4U S;  2RF6 A;  3D44 A;  4NYH A;  1SUG A;  2BIJ A;  2CNI A;  4PYH A;  4WU2 A;  1Q6P A;  4GE2 A;  3I36 A;  3F9B A;  3SME A;  2VEU A;  1M3G A;  3O4U A;  4J51 A;  4QUM A;  1BZH A;  3EZZ A;  2I75 A;  3A5J A;  5K22 A;  2E0T A;  2P4D A;  1XXP A;  2B4O A;  2PA5 A;  1NWE A;  2I3U A;  4WTY A;  1Q6N A;  3ZM2 A;  1QXK A;  2AHS A;  3QCK A;  1RPM A;  4Z6B A;  2CM7 A;  2NT2 A;  3O5X A;  2I4G A;  4NWF A;  2PT0 A;  5KAC A;  2H4K A;  3EU0 A;  3F81 A;  3PS5 A;  1FPZ A;  5BX1 A;  2I6J A;  2I6I A;  3ZV2 A;  4RI5 A;  2PSZ A;  3V0I A;  5IBM A;  1PYN A;  3GXG A;  3EAX A;  4RI4 A;  4GE5 A;  5KA8 A;  2QCJ A;  4RH5 A;  1BZJ A;  3AWG A;  2FJN A;  2F70 A;  4GE6 A;  2F46 A;  3CWE A;  2B4U A;  4DGX A;  5M43 A;  2B07 A;  3OLR A;  2OOQ A;  3NME A;  1J4X A;  4S0G A;  2QDM A;  1G1F A;  5BUG A;  1V3A A;  2B4S A;  2HB1 A;  3RGO A;  2IMG A;  1AAX A;  1T4J A;  3D42 A;  5K25 A;  2H4V A;  2QDC A;  1YTN A;  5K9W A;  2ZMM A;  1YPT A;  4ZRT A;  1EEN A;  1ZCL A;  2G59 A;  4HJQ A;  2C7S A;  3V0E A;  3OMH A;  1Q6S A;  2QBP A;  1Q6T A;  4QAP A;  1OHD A;  5KA3 A;  1NL9 A;  4H34 A;  2OC3 A;  4GRY A;  1LAR A;  1XBO A;  4BPC A;  5KAA A;  2QBS A;  4WOH A;  4JMJ A;  4RHG A;  1YTS A;  3QCE A;  3F99 A;  5EHR A;  1G1G A;  4OHD A;  3QCD A;  2H4G A;  2HNQ A;  1MKP A;  4OHI A;  1I57 A;  1OEV A;  1PH0 A;  3N0A A;  3QCJ A;  5KA2 A;  4RKK A;  1YN9 A;  4ZI4 A;  2G6Z A;  1PA9 A;  4Y2E A;  2AZR A;  2NV5 A;  1Q6J A;  4JBC A;  4D3Q A;  5KA4 A;  1NO6 A;  4WU3 A;  2CMC A;  4YAA A;  3V0D A;  3ZMQ A;  1JF7 A;  2Q05 A;  5GTJ A;  1T49 A;  1YGR A;  4D3R A;  4ZN5 A;  3M4U A;  1ECV A;  2B49 A;  2QEP A;  2R0B A;  2I6P A;  3AWF A;  1YGU A;  2I4H A;  2A3K A;  3V0H A;  3QCF A;  2FH7 A;  4OHL A;  3QKQ A;  2A8B A;  3GXH A;  5KA1 A;  1OES A;  4I8N A;  3ZM0 A;  4GFU A;  2OZ5 A;  3BRH A;  3I7Z A;  3RGQ A;  1KAV A;  1XXV A;  3MOZ A;  1NNY A;  2HNP A;  2B4P A;  1PTV A;  3QCC A;  4RDD A;  2H03 A;  1LYV A;  2GP0 A;  1G1H A;  4TVV A;  5J8R A;  2CNF A;  1OEM X;  1OET A;  1D5R A;  1YWF A;  5KA9 A;  1ONY A;  4HJP A;  3EMU A;  2Y96 A;  1R6H A;  3O4S A;  2J16 B;  4GRZ A;  1BZC A;  3BLU A;  4R0S A;  2J16 A;  5KA7 A;  2P6X A;  2VEW A;  5KAD A;  1YTW A;  2MBC A;  3H2X A;  4JNB A;  1X24 A;  1OEU A;  2DXP A;  2HXP A;  1OHC A;  1Q6M A;  4QBW A;  3D1O A;  3I80 A;  4D3P A;  2Y2F A;  3V0G A;  4QAH A;  4GS0 A;  2HCM A;  1XM2 A;  2CMB A;  2VEY A;  3QCL A;  5K24 A;  5I6V A;  3CM3 A;  5HDE A;  3S3F A;  3BM8 A;  5KA0 A;  3QCM A;  4OHE A;  2QBR A;  2CM2 A;  2CJZ A;  3QCI A;  2QDP A;  2I4E A;  3S3H A;  1G7G A;  2NLK A;  1U25 A;  4R30 A;  4JMK A;  4NX8 A;  3V0J A;  4QBE A;  5K23 A;  1Q1M A;  4OHH A;  1PTY A;  2F71 A;  3O3L A;  3ZM1 A;  2I6O A;  1C86 A;  3QCN A;  4KI9 A;  4DGP A;  2I6M A;  1YZ4 A;  3S4O A;  4NND A;  3V0F A;  3LJ8 A;  3D1Q A;  2BGE A;  1A5Y A;  2I1Y A;  2GJT A;  2I5X A;  4KYQ A;  1JLN A;  2B3O A;  1C84 A;  2NZ6 A;  2BV5 A;  1OEO X;  4B04 A;  1WCH A;  1ZCK A;  1C88 A;  1U26 A;  1U24 A;  3S4E A;  1ONZ A;  1PTU A;  2F6Y A;  2SHP A;  2YDU A;  1WAX A;  1PA1 A;  2NTA A;  1QZ0 A;  1GWZ A;  1C87 A;  2CM3 A;  1I9T A;  1ZZW A;  2FJM A;  2HVL A;  3BLT A;  3S3E A;  1I9S A;  2BZL A;  2QBQ A;  4RH9 A;  4YR8 B;  4GFV A;  2F6F A;  2J17 A;  5EHP A;  2I3R A;  1FQ1 A;  2CFV A;  1WRM A;  2OUD A;  1C85 A;  2M3V A;  3RZ2 A;  2CM8 A;  3EB1 A;  5IBS A;  2F6T A;  2GWO A;  1OHE A;  4QUN A;  1YFO A;  4KYR A;  5BZX A;  1LQF A;  4GWF A;  4BJO A;  2CNG A;  3QCG A;  1FPR A;  1NWL A;  1L8K A;  2ESB A;  3ZM3 A;  3U96 A;  2VEV A;  1PTT A;  4HRF A;  5LXQ B;  2Q47 A;  2F6V A;  2CNE A;  4IKC A;  1NZ7 A;  2WGP A;  1C83 A;  2PBN A;  2HC1 A;  1G4W R;  4MBB A;  4AZ1 A;  2HC2 A;  4ICZ A;  2ZN7 A;  4Y14 A;  1G7F A;  2C46 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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