1L8GA

Crystal structure of ptp1b complexed with 7-(1,1-dioxo-1h-benzo[d]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5h-thieno[2,3-c]pyran-3-carboxylic acid
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
297
structure length
297
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKTYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLDMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1
total genus 106
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2002-03-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 1l8gA00
3D1OA 1P15A 2SHPA 1A5YA 1NWEA 2CNIA 3V0HA 4WU2A 4DGXA 1JLNA 5K23A 1KAVA 3QCCA 3S3HA 2BGEA 1EENA 1PTVA 1L8KA 4JNBA 3OMHA 4HJPA 4QUNA 3S3EA 3PS5A 3D1HA 4D3RA 2NTAA 1SUGA 4OHEA 4Y14A 1Q6PA 1C83A 2CM2A 4Z6BA 1NNYA 5BUGA 2VEUA 1NL9A 5MMZB 1KAKA 3V0FA 3O4SA 2VEYA 1T48A 1JF7A 2BZLA 3O5XA 2F6ZA 4JMJA 1WCHA 2HVLA 5IBMA 4GS0A 1QXKA 4YR8B 1ZCKA 1ZZWA 1FQ1A 4RKKA 2QDMA 2F6FA 2QDPA 2YDUA 2HB1A 4WTYA 2PQ5A 1NO6A 2F71A 1T49A 2H04A 1XRIA 3QCEA 1Q6SA 2C7SA 2OOQA 4ZRTA 1Q6TA 2GJTA 2Y2FA 3AWGA 1V3AA 1YTNA 2CMBA 3OLRA 4IKCA 2NZ6A 4HRFA 2I3RA 2CJZA 1YTSA 2JJDA 4GWFA 5K9VA 1OESA 1YN9A 4ERCA 1BZCA 2CM7A 2IMGA 3H2XA 3QCHA 1WAXA 1WRMA 2B4OA 3EMUA 5K25A 1OHCA 1J4XA 1OEVA 3ZM0A 3O4UA 4DGPA 1Q6MA 2B07A 3I7ZA 1G1FA 2H4KA 2H4GA 3QCMA 2QCTA 3S3FA 2FH7A 5KABA 3EZZA 1GFYA 1I9SA 2I42A 1T4JA 2OUDA 4HJQA 1OHEA 2WGPA 3B7OA 3BM8A 1G1HA 4ICZA 3QCGA 3D44A 3F99A 2MBCA 5EHRA 4JBCA 4GRZA 1RXDA 3M4UA 2I6MA 3D42A 1YPTA 5KACA 4QUMA 3QCBA 4NWGA 4QBEA 4NYHA 2F46A 1Q6JA 3ZM3A 4QAHA 1Q6NA 3S4EA 2QDCA 2BV5A 2I6PA 4QAPA 4OHDA 1R6HA 2B4PA 4RH5A 2P4DA 2CNFA 1X24A 3ZMQA 2I1YA 2HXPA 3BLTA 4GE5A 4H34A 4PYHA 1PTTA 1G7GA 1ZCLA 3O4TA 1G7FA 4MBBA 1C86A 2CMCA 4OHIA 4BJOA 3EAXA 3RGOA 2HNPA 5K24A 1ECVA 2QBPA 2A8BA 5K9WA 2I6IA 3F41A 4JMKA 1PXHA 2H4VA 2PBNA 1PTYA 4WOHA 1I9TA 3CWEA 3V0EA 1LYVA 1I57A 2G59A 5HDEA 1LQFA 3S4OA 2CNEA 3MOZA 5EHPA 4YAAA 3CM3A 2J17A 2OZ5A 5BX1A 2G6ZA 5IBSA 1NZ7A 2FJNA 1AAXA 2I4HA 1PH0A 2PA5A 4R0SA 2QCJA 1RPMA 2C46A 2GP0A 5AWXA 1XBOA 2I4GA 3ZM2A 3AWEA 4TVVA 4GRYA 1PA9A 2I5XA 2CM8A 4I8NA 3N0AA 2VEWA 2OC3A 2B4SA 3BLUA 1L8GA 3S3KA 2H03A 4RDDA 1YTWA 2J16B 3QCNA 4ZN5A 1ONYA 5BZXA 1YFOA 2HC1A 2F6VA 2NV5A 4R0TA 3V0JA 1LARA 1D5RA 3LJ8A 2CNHA 1ONZA 2HY3A 2NLKA 4KI9A 4R30A 4B04A 1PYNA 4GFVA 2B4UA 2ZMMA 5M43A 1U26A 5KA7A 1XXPA 2RF6A 1EEOA 1U25A 3QKQA 2I3UA 4QBWA 1QZ0A 3F9BA 1Q1MA 3EU0A 1G4US 1OHDA 2Q05A 5KA0A 1FPRA 1BZHA 2QEPA 4NX8A 4BPCA 3A5JA 3O3LA 5LXQB 4NNDA 2B3OA 3V0IA 3MMJA 4NWFA 2AHSA 3D1QA 2NT7A 3SMEA 2ZN7A 1YZ4A 1M3GA 2J16A 3QKPA 5J8RA 2PSZA 4RI4A 1C88A 5I6VA 1PA1A 3I36A 4H1OA 2VEVA 3V0DA 2Y96A 4S0GA 3QCLA 5KA1A 1NWLA 5KADA 4GE2A 2FJMA 2F6YA 2PI7A 1OETA 3NMEA 1XXVA 3SR9A 3D9CA 3I80A 2A3KA 2I4EA 4GE6A 1G4WR 2QBSA 4PVGA 3U96A 1ZC0A 3ZM1A 1MKPA 2F6WA 5KA2A 4J51A 3GXHA 3QCFA 4AZ1A 3ZMPA 2ESBA 2I6OA 2HCMA 3RGQA 3QCKA 2H02A 4ZI4A 3EB1A 1FPZA 2F70A 2P6XA 2B49A 4RH9A 2VEXA 3QCJA 3QCIA 1C87A 4GFUA 2F6TA 2I6JA 5KAAA 1PTUA 2PT0A 3V0GA 1BZJA 2BGDA 2AZRA 1C84A 3QCDA 4D3PA 3F9AA 2BIJA 2HNQA 1YWFA 2Q47A 3BRHA 4OHLA 1OEMX 1C85A 2CMAA 4D3QA 2E0TA 1YGRA 3A5KA 3RZ2A 3ZV2A 1YGUA 1G1GA 4KYQA 2CM3A 2M3VA 1OEOX 2QBRA 4RI5A 1OEUA 4KYRA 4Y2EA 2DXPA 1VHRA 3RO1A 5K22A 2NT2A 4RHGA 1U24A 5BZZA 5KA3A 2CFVA 2CNGA 3F81A 2R0BA 2GWOA 4WU3A 1XM2A 3MOWA 5KA4A 3GXGA 5KA8A 3AWFA 5KA9A 4OHHA 5GTJA 2QBQA 2HC2A 1GWZA 2I75A
chains in the Genus database with same CATH superfamily
3D1OA 1P15A 2SHPA 3UAGA 2AM1A 1UAGA 1A5YA 1NWEA 2CNIA 3V0HA 2UUPA 4WU2A 4DGXA 1JLNA 5K23A 1KAVA 3QCCA 3S3HA 2BGEA 1EENA 1PTVA 1L8KA 4JNBA 3NRSA 3OMHA 2Y67A 4HJPA 4QUNA 3S3EA 3PS5A 3D1HA 1P3DA 4D3RA 2NTAA 2X5OA 1SUGA 4OHEA 4Y14A 1J6UA 1Q6PA 1C83A 2CM2A 4Z6BA 1NNYA 5BUGA 2VEUA 1NL9A 5MMZB 1KAKA 3V0FA 3O4SA 2VEYA 1T48A 1JF7A 2BZLA 3O5XA 2F6ZA 4JMJA 1WCHA 2HVLA 5IBMA 4GS0A 1O5ZA 1QXKA 3LK7A 4YR8B 1ZCKA 1ZZWA 1FQ1A 4RKKA 2QDMA 2F6FA 2QDPA 2YDUA 2HB1A 4C12A 4WTYA 2PQ5A 1NO6A 2F71A 2JFFA 1T49A 2H04A 1XRIA 3QCEA 1Q6SA 3PYZA 2C7SA 2OOQA 4ZRTA 1Q6TA 2GJTA 2Y2FA 3AWGA 1V3AA 1YTNA 2CMBA 3OLRA 4IKCA 2NZ6A 4HRFA 2I3RA 2CJZA 1YTSA 2JJDA 4GWFA 5K9VA 1OESA 4C13A 2Y68A 1YN9A 3ZL8A 4ERCA 1BZCA 2CM7A 2IMGA 3H2XA 1WAXA 1WRMA 2B4OA 3EMUA 3QCHA 5K25A 1OHCA 1J4XA 1OEVA 3ZM0A 3O4UA 4DGPA 1Q6MA 2B07A 1G1FA 2H4GA 2H4KA 3I7ZA 3MVNA 3QCMA 2QCTA 3S3FA 2FH7A 5KABA 3EZZA 1GFYA 1I9SA 2I42A 1T4JA 2OUDA 4HJQA 1OHEA 2WGPA 2GC6A 1E8CA 3HN7A 5A5FA 3B7OA 3BM8A 2GCAA 1G1HA 4ICZA 3QCGA 3D44A 3F99A 2MBCA 4HV4A 5EHRA 2GCBA 4JBCA 4GRZA 1RXDA 3M4UA 2I6MA 3D42A 1YPTA 5KACA 4QUMA 3QCBA 4NWGA 4QBEA 4NYHA 1GQYA 2F46A 1Q6JA 3ZM3A 4QAHA 1Q6NA 3S4EA 2QDCA 2BV5A 2I6PA 4QAPA 1GQQA 1JBWA 4OHDA 4UAGA 1R6HA 2B4PA 4RH5A 2P4DA 2CNFA 1X24A 3ZMQA 2I1YA 2HXPA 3BLTA 4GE5A 1GG4A 1EEHA 4CVLA 4H34A 4PYHA 1PTTA 1G7GA 1ZCLA 3O4TA 1G7FA 4MBBA 1C86A 2CMCA 4OHIA 4BJOA 3EAXA 3RGOA 2HNPA 5K24A 1ECVA 2QBPA 2A8BA 5K9WA 2I6IA 3F41A 4JMKA 1PXHA 2H4VA 2PBNA 1PTYA 4WOHA 5A5EA 1I9TA 3CWEA 3V0EA 1LYVA 1I57A 2G59A 5HDEA 1LQFA 3S4OA 2CNEA 3MOZA 5EHPA 4YAAA 3CM3A 2J17A 2OZ5A 5BX1A 2G6ZA 5IBSA 3ZM5A 1NZ7A 2FJNA 1AAXA 2I4HA 1PH0A 2PA5A 4R0SA 2WTZA 2QCJA 2VOSA 1RPMA 2C46A 2GP0A 5AWXA 1XBOA 2I4GA 2Y66A 3ZM2A 3AWEA 4TVVA 4GRYA 1PA9A 2I5XA 2CM8A 4I8NA 3N0AA 2VEWA 2OC3A 2B4SA 3BLUA 1L8GA 2JFGA 3S3KA 2H03A 4RDDA 1YTWA 2J16B 3QCNA 4ZN5A 1ONYA 5BZXA 1YFOA 2HC1A 2F6VA 2NV5A 4R0TA 3V0JA 1LARA 1D5RA 3LJ8A 2CNHA 1ONZA 2HY3A 2NLKA 4CVKA 4KI9A 4R30A 4B04A 2XJAA 1PYNA 4GFVA 2B4UA 2ZMMA 5M43A 1U26A 5KA7A 1XXPA 2RF6A 1EEOA 1U25A 3QKQA 2I3UA 2WJPA 4QBWA 1QZ0A 4BUCA 3F9BA 1W78A 1Q1MA 3EU0A 1G4US 1OHDA 2Q05A 2AM2A 1FGSA 5KA0A 1FPRA 1BZHA 2QEPA 4NX8A 4BPCA 3A5JA 3O3LA 5LXQB 4NNDA 2GC5A 2B3OA 3V0IA 3MMJA 4NWFA 2AHSA 3D1QA 2NT7A 3SMEA 2ZN7A 1YZ4A 1M3GA 1W7KA 2J16A 3QKPA 5J8RA 2PSZA 4RI4A 1C88A 5I6VA 3QCZA 1PA1A 3I36A 4H1OA 2VEVA 3V0DA 2Y96A 4S0GA 3QCLA 5KA1A 1NWLA 5KADA 4GE2A 2FJMA 2F6YA 2PI7A 1OETA 3NMEA 1XXVA 3SR9A 3D9CA 3I80A 2A3KA 2I4EA 4GE6A 1G4WR 2QBSA 4PVGA 3U96A 1ZC0A 3ZM1A 1MKPA 2F6WA 5KA2A 4J51A 3GXHA 3QCFA 4AZ1A 3ZMPA 2ESBA 2I6OA 4ZIYA 2HCMA 2VTEA 2JFHA 3RGQA 3ZM6A 3QCKA 1E0DA 2H02A 4ZI4A 3EB1A 1FPZA 2F70A 2P6XA 2F00A 2B49A 2VTDA 4RH9A 2VEXA 3QCJA 3QCIA 1C87A 4GFUA 2F6TA 2I6JA 5KAAA 1PTUA 2PT0A 4CVMA 3V0GA 1BZJA 2XPCA 4QF5A 2BGDA 2UAGA 2AZRA 1C84A 3QCDA 4D3PA 3F9AA 2BIJA 2HNQA 1YWFA 2Q47A 3BRHA 4OHLA 1OEMX 1C85A 2CMAA 4D3QA 2E0TA 1YGRA 3A5KA 3RZ2A 3ZV2A 1YGUA 1G1GA 4KYQA 2CM3A 2M3VA 1OEOX 2QBRA 4RI5A 1OEUA 4KYRA 4Y2EA 2DXPA 1VHRA 3RO1A 5K22A 2NT2A 4RHGA 1U24A 5BZZA 2Y1OA 2VORA 5KA3A 1JBVA 2CFVA 2CNGA 3F81A 2R0BA 2GWOA 4WU3A 1XM2A 3MOWA 5KA4A 3GXGA 5KA8A 3AWFA 5KA9A 1P31A 4OHHA 4BUBA 2UUOA 5GTJA 4QDIA 2QBQA 2HC2A 1GWZA 3N2AA 2I75A
chains in the Genus database with same CATH topology
3D1OA 1P15A 2SHPA 1A5YA 1NWEA 2CNIA 3V0HA 4WU2A 4DGXA 1JLNA 5K23A 1KAVA 3QCCA 3S3HA 2BGEA 1EENA 1PTVA 1L8KA 4JNBA 3OMHA 4HJPA 4QUNA 3S3EA 3PS5A 3D1HA 4D3RA 2NTAA 1SUGA 4OHEA 4Y14A 1Q6PA 1C83A 2CM2A 4Z6BA 1NNYA 5BUGA 2VEUA 1NL9A 5MMZB 1KAKA 3V0FA 3O4SA 2VEYA 1T48A 1JF7A 2BZLA 3O5XA 2F6ZA 4JMJA 1WCHA 2HVLA 5IBMA 4GS0A 1QXKA 4YR8B 1ZCKA 1ZZWA 1FQ1A 4RKKA 2QDMA 2F6FA 2QDPA 2YDUA 2HB1A 4WTYA 2PQ5A 1NO6A 2F71A 1T49A 2H04A 1XRIA 3QCEA 1Q6SA 2C7SA 2OOQA 4ZRTA 1Q6TA 2GJTA 2Y2FA 3AWGA 1V3AA 1YTNA 2CMBA 3OLRA 4IKCA 2NZ6A 4HRFA 2I3RA 2CJZA 1YTSA 2JJDA 4GWFA 5K9VA 1OESA 1YN9A 4ERCA 1BZCA 2CM7A 2IMGA 3H2XA 3QCHA 1WAXA 1WRMA 2B4OA 3EMUA 5K25A 1OHCA 1J4XA 1OEVA 3ZM0A 3O4UA 4DGPA 1Q6MA 2B07A 3I7ZA 1G1FA 2H4KA 2H4GA 3QCMA 2QCTA 3S3FA 2FH7A 5KABA 3EZZA 1GFYA 1I9SA 2I42A 1T4JA 2OUDA 4HJQA 1OHEA 2WGPA 3B7OA 3BM8A 1G1HA 4ICZA 3QCGA 3D44A 3F99A 2MBCA 5EHRA 4JBCA 4GRZA 1RXDA 3M4UA 2I6MA 3D42A 1YPTA 5KACA 4QUMA 3QCBA 4NWGA 4QBEA 4NYHA 2F46A 1Q6JA 3ZM3A 4QAHA 1Q6NA 3S4EA 2QDCA 2BV5A 2I6PA 4QAPA 4OHDA 1R6HA 2B4PA 4RH5A 2P4DA 2CNFA 1X24A 3ZMQA 2I1YA 2HXPA 3BLTA 4GE5A 4H34A 4PYHA 1PTTA 1G7GA 1ZCLA 3O4TA 1G7FA 4MBBA 1C86A 2CMCA 4OHIA 4BJOA 3EAXA 3RGOA 2HNPA 5K24A 1ECVA 2QBPA 2A8BA 5K9WA 2I6IA 3F41A 4JMKA 1PXHA 2H4VA 2PBNA 1PTYA 4WOHA 1I9TA 3CWEA 3V0EA 1LYVA 1I57A 2G59A 5HDEA 1LQFA 3S4OA 2CNEA 3MOZA 5EHPA 4YAAA 3CM3A 2J17A 2OZ5A 5BX1A 2G6ZA 5IBSA 1NZ7A 2FJNA 1AAXA 2I4HA 1PH0A 2PA5A 4R0SA 2QCJA 1RPMA 2C46A 2GP0A 5AWXA 1XBOA 2I4GA 3ZM2A 3AWEA 4TVVA 4GRYA 1PA9A 2I5XA 2CM8A 4I8NA 3N0AA 2VEWA 2OC3A 2B4SA 3BLUA 1L8GA 3S3KA 2H03A 4RDDA 1YTWA 2J16B 3QCNA 4ZN5A 1ONYA 5BZXA 1YFOA 2HC1A 2F6VA 2NV5A 4R0TA 3V0JA 1LARA 1D5RA 3LJ8A 2CNHA 1ONZA 2HY3A 2NLKA 4KI9A 4R30A 4B04A 1PYNA 4GFVA 2B4UA 2ZMMA 5M43A 1U26A 5KA7A 1XXPA 2RF6A 1EEOA 1U25A 3QKQA 2I3UA 4QBWA 1QZ0A 3F9BA 1Q1MA 3EU0A 1G4US 1OHDA 2Q05A 5KA0A 1FPRA 1BZHA 2QEPA 4NX8A 4BPCA 3A5JA 3O3LA 5LXQB 4NNDA 2B3OA 3V0IA 3MMJA 4NWFA 2AHSA 3D1QA 2NT7A 3SMEA 2ZN7A 1YZ4A 1M3GA 2J16A 3QKPA 5J8RA 2PSZA 4RI4A 1C88A 5I6VA 1PA1A 3I36A 4H1OA 2VEVA 3V0DA 2Y96A 4S0GA 3QCLA 5KA1A 1NWLA 5KADA 4GE2A 2FJMA 2F6YA 2PI7A 1OETA 3NMEA 1XXVA 3SR9A 3D9CA 3I80A 2A3KA 2I4EA 4GE6A 1G4WR 2QBSA 4PVGA 3U96A 1ZC0A 3ZM1A 1MKPA 2F6WA 5KA2A 4J51A 3GXHA 3QCFA 4AZ1A 3ZMPA 2ESBA 2I6OA 2HCMA 3RGQA 3QCKA 2H02A 4ZI4A 3EB1A 1FPZA 2F70A 2P6XA 2B49A 4RH9A 2VEXA 3QCJA 3QCIA 1C87A 4GFUA 2F6TA 2I6JA 5KAAA 1PTUA 2PT0A 3V0GA 1BZJA 2BGDA 2AZRA 1C84A 3QCDA 4D3PA 3F9AA 2BIJA 2HNQA 1YWFA 2Q47A 3BRHA 4OHLA 1OEMX 1C85A 2CMAA 4D3QA 2E0TA 1YGRA 3A5KA 3RZ2A 3ZV2A 1YGUA 1G1GA 4KYQA 2CM3A 2M3VA 1OEOX 2QBRA 4RI5A 1OEUA 4KYRA 4Y2EA 2DXPA 1VHRA 3RO1A 5K22A 2NT2A 4RHGA 1U24A 5BZZA 5KA3A 2CFVA 2CNGA 3F81A 2R0BA 2GWOA 4WU3A 1XM2A 3MOWA 5KA4A 3GXGA 5KA8A 3AWFA 5KA9A 4OHHA 5GTJA 2QBQA 2HC2A 1GWZA 2I75A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3D1O A;  1P15 A;  2SHP A;  1A5Y A;  1NWE A;  2CNI A;  3V0H A;  4WU2 A;  4DGX A;  1JLN A;  5K23 A;  1KAV A;  3QCC A;  3S3H A;  2BGE A;  1EEN A;  1PTV A;  1L8K A;  4JNB A;  3OMH A;  4HJP A;  4QUN A;  3S3E A;  3PS5 A;  3D1H A;  4D3R A;  2NTA A;  1SUG A;  4OHE A;  4Y14 A;  1Q6P A;  1C83 A;  2CM2 A;  4Z6B A;  1NNY A;  5BUG A;  2VEU A;  1NL9 A;  5MMZ B;  1KAK A;  3V0F A;  3O4S A;  2VEY A;  1T48 A;  1JF7 A;  2BZL A;  3O5X A;  2F6Z A;  4JMJ A;  1WCH A;  2HVL A;  5IBM A;  4GS0 A;  1QXK A;  4YR8 B;  1ZCK A;  1ZZW A;  1FQ1 A;  4RKK A;  2QDM A;  2F6F A;  2QDP A;  2YDU A;  2HB1 A;  4WTY A;  2PQ5 A;  1NO6 A;  2F71 A;  1T49 A;  2H04 A;  1XRI A;  3QCE A;  1Q6S A;  2C7S A;  2OOQ A;  4ZRT A;  1Q6T A;  2GJT A;  2Y2F A;  3AWG A;  1V3A A;  1YTN A;  2CMB A;  3OLR A;  4IKC A;  2NZ6 A;  4HRF A;  2I3R A;  2CJZ A;  1YTS A;  2JJD A;  4GWF A;  5K9V A;  1OES A;  1YN9 A;  4ERC A;  1BZC A;  2CM7 A;  2IMG A;  3H2X A;  3QCH A;  1WAX A;  1WRM A;  2B4O A;  3EMU A;  5K25 A;  1OHC A;  1J4X A;  1OEV A;  3ZM0 A;  3O4U A;  4DGP A;  1Q6M A;  2B07 A;  3I7Z A;  1G1F A;  2H4K A;  2H4G A;  3QCM A;  2QCT A;  3S3F A;  2FH7 A;  5KAB A;  3EZZ A;  1GFY A;  1I9S A;  2I42 A;  1T4J A;  2OUD A;  4HJQ A;  1OHE A;  2WGP A;  3B7O A;  3BM8 A;  1G1H A;  4ICZ A;  3QCG A;  3D44 A;  3F99 A;  2MBC A;  5EHR A;  4JBC A;  4GRZ A;  1RXD A;  3M4U A;  2I6M A;  3D42 A;  1YPT A;  5KAC A;  4QUM A;  3QCB A;  4NWG A;  4QBE A;  4NYH A;  2F46 A;  1Q6J A;  3ZM3 A;  4QAH A;  1Q6N A;  3S4E A;  2QDC A;  2BV5 A;  2I6P A;  4QAP A;  4OHD A;  1R6H A;  2B4P A;  4RH5 A;  2P4D A;  2CNF A;  1X24 A;  3ZMQ A;  2I1Y A;  2HXP A;  3BLT A;  4GE5 A;  4H34 A;  4PYH A;  1PTT A;  1G7G A;  1ZCL A;  3O4T A;  1G7F A;  4MBB A;  1C86 A;  2CMC A;  4OHI A;  4BJO A;  3EAX A;  3RGO A;  2HNP A;  5K24 A;  1ECV A;  2QBP A;  2A8B A;  5K9W A;  2I6I A;  3F41 A;  4JMK A;  1PXH A;  2H4V A;  2PBN A;  1PTY A;  4WOH A;  1I9T A;  3CWE A;  3V0E A;  1LYV A;  1I57 A;  2G59 A;  5HDE A;  1LQF A;  3S4O A;  2CNE A;  3MOZ A;  5EHP A;  4YAA A;  3CM3 A;  2J17 A;  2OZ5 A;  5BX1 A;  2G6Z A;  5IBS A;  1NZ7 A;  2FJN A;  1AAX A;  2I4H A;  1PH0 A;  2PA5 A;  4R0S A;  2QCJ A;  1RPM A;  2C46 A;  2GP0 A;  5AWX A;  1XBO A;  2I4G A;  3ZM2 A;  3AWE A;  4TVV A;  4GRY A;  1PA9 A;  2I5X A;  2CM8 A;  4I8N A;  3N0A A;  2VEW A;  2OC3 A;  2B4S A;  3BLU A;  1L8G A;  3S3K A;  2H03 A;  4RDD A;  1YTW A;  2J16 B;  3QCN A;  4ZN5 A;  1ONY A;  5BZX A;  1YFO A;  2HC1 A;  2F6V A;  2NV5 A;  4R0T A;  3V0J A;  1LAR A;  1D5R A;  3LJ8 A;  2CNH A;  1ONZ A;  2HY3 A;  2NLK A;  4KI9 A;  4R30 A;  4B04 A;  1PYN A;  4GFV A;  2B4U A;  2ZMM A;  5M43 A;  1U26 A;  5KA7 A;  1XXP A;  2RF6 A;  1EEO A;  1U25 A;  3QKQ A;  2I3U A;  4QBW A;  1QZ0 A;  3F9B A;  1Q1M A;  3EU0 A;  1G4U S;  1OHD A;  2Q05 A;  5KA0 A;  1FPR A;  1BZH A;  2QEP A;  4NX8 A;  4BPC A;  3A5J A;  3O3L A;  5LXQ B;  4NND A;  2B3O A;  3V0I A;  3MMJ A;  4NWF A;  2AHS A;  3D1Q A;  2NT7 A;  3SME A;  2ZN7 A;  1YZ4 A;  1M3G A;  2J16 A;  3QKP A;  5J8R A;  2PSZ A;  4RI4 A;  1C88 A;  5I6V A;  1PA1 A;  3I36 A;  4H1O A;  2VEV A;  3V0D A;  2Y96 A;  4S0G A;  3QCL A;  5KA1 A;  1NWL A;  5KAD A;  4GE2 A;  2FJM A;  2F6Y A;  2PI7 A;  1OET A;  3NME A;  1XXV A;  3SR9 A;  3D9C A;  3I80 A;  2A3K A;  2I4E A;  4GE6 A;  1G4W R;  2QBS A;  4PVG A;  3U96 A;  1ZC0 A;  3ZM1 A;  1MKP A;  2F6W A;  5KA2 A;  4J51 A;  3GXH A;  3QCF A;  4AZ1 A;  3ZMP A;  2ESB A;  2I6O A;  2HCM A;  3RGQ A;  3QCK A;  2H02 A;  4ZI4 A;  3EB1 A;  1FPZ A;  2F70 A;  2P6X A;  2B49 A;  4RH9 A;  2VEX A;  3QCJ A;  3QCI A;  1C87 A;  4GFU A;  2F6T A;  2I6J A;  5KAA A;  1PTU A;  2PT0 A;  3V0G A;  1BZJ A;  2BGD A;  2AZR A;  1C84 A;  3QCD A;  4D3P A;  3F9A A;  2BIJ A;  2HNQ A;  1YWF A;  2Q47 A;  3BRH A;  4OHL A;  1OEM X;  1C85 A;  2CMA A;  4D3Q A;  2E0T A;  1YGR A;  3A5K A;  3RZ2 A;  3ZV2 A;  1YGU A;  1G1G A;  4KYQ A;  2CM3 A;  2M3V A;  1OEO X;  2QBR A;  4RI5 A;  1OEU A;  4KYR A;  4Y2E A;  2DXP A;  1VHR A;  3RO1 A;  5K22 A;  2NT2 A;  4RHG A;  1U24 A;  5BZZ A;  5KA3 A;  2CFV A;  2CNG A;  3F81 A;  2R0B A;  2GWO A;  4WU3 A;  1XM2 A;  3MOW A;  5KA4 A;  3GXG A;  5KA8 A;  3AWF A;  5KA9 A;  4OHH A;  5GTJ A;  2QBQ A;  2HC2 A;  1GWZ A;  2I75 A; 
#chains in the Genus database with same CATH topology
 3D1O A;  1P15 A;  2SHP A;  3UAG A;  2AM1 A;  1UAG A;  1A5Y A;  1NWE A;  2CNI A;  3V0H A;  2UUP A;  4WU2 A;  4DGX A;  1JLN A;  5K23 A;  1KAV A;  3QCC A;  3S3H A;  2BGE A;  1EEN A;  1PTV A;  1L8K A;  4JNB A;  3NRS A;  3OMH A;  2Y67 A;  4HJP A;  4QUN A;  3S3E A;  3PS5 A;  3D1H A;  1P3D A;  4D3R A;  2NTA A;  2X5O A;  1SUG A;  4OHE A;  4Y14 A;  1J6U A;  1Q6P A;  1C83 A;  2CM2 A;  4Z6B A;  1NNY A;  5BUG A;  2VEU A;  1NL9 A;  5MMZ B;  1KAK A;  3V0F A;  3O4S A;  2VEY A;  1T48 A;  1JF7 A;  2BZL A;  3O5X A;  2F6Z A;  4JMJ A;  1WCH A;  2HVL A;  5IBM A;  4GS0 A;  1O5Z A;  1QXK A;  3LK7 A;  4YR8 B;  1ZCK A;  1ZZW A;  1FQ1 A;  4RKK A;  2QDM A;  2F6F A;  2QDP A;  2YDU A;  2HB1 A;  4C12 A;  4WTY A;  2PQ5 A;  1NO6 A;  2F71 A;  2JFF A;  1T49 A;  2H04 A;  1XRI A;  3QCE A;  1Q6S A;  3PYZ A;  2C7S A;  2OOQ A;  4ZRT A;  1Q6T A;  2GJT A;  2Y2F A;  3AWG A;  1V3A A;  1YTN A;  2CMB A;  3OLR A;  4IKC A;  2NZ6 A;  4HRF A;  2I3R A;  2CJZ A;  1YTS A;  2JJD A;  4GWF A;  5K9V A;  1OES A;  4C13 A;  2Y68 A;  1YN9 A;  3ZL8 A;  4ERC A;  1BZC A;  2CM7 A;  2IMG A;  3H2X A;  1WAX A;  1WRM A;  2B4O A;  3EMU A;  3QCH A;  5K25 A;  1OHC A;  1J4X A;  1OEV A;  3ZM0 A;  3O4U A;  4DGP A;  1Q6M A;  2B07 A;  1G1F A;  2H4G A;  2H4K A;  3I7Z A;  3MVN A;  3QCM A;  2QCT A;  3S3F A;  2FH7 A;  5KAB A;  3EZZ A;  1GFY A;  1I9S A;  2I42 A;  1T4J A;  2OUD A;  4HJQ A;  1OHE A;  2WGP A;  2GC6 A;  1E8C A;  3HN7 A;  5A5F A;  3B7O A;  3BM8 A;  2GCA A;  1G1H A;  4ICZ A;  3QCG A;  3D44 A;  3F99 A;  2MBC A;  4HV4 A;  5EHR A;  2GCB A;  4JBC A;  4GRZ A;  1RXD A;  3M4U A;  2I6M A;  3D42 A;  1YPT A;  5KAC A;  4QUM A;  3QCB A;  4NWG A;  4QBE A;  4NYH A;  1GQY A;  2F46 A;  1Q6J A;  3ZM3 A;  4QAH A;  1Q6N A;  3S4E A;  2QDC A;  2BV5 A;  2I6P A;  4QAP A;  1GQQ A;  1JBW A;  4OHD A;  4UAG A;  1R6H A;  2B4P A;  4RH5 A;  2P4D A;  2CNF A;  1X24 A;  3ZMQ A;  2I1Y A;  2HXP A;  3BLT A;  4GE5 A;  1GG4 A;  1EEH A;  4CVL A;  4H34 A;  4PYH A;  1PTT A;  1G7G A;  1ZCL A;  3O4T A;  1G7F A;  4MBB A;  1C86 A;  2CMC A;  4OHI A;  4BJO A;  3EAX A;  3RGO A;  2HNP A;  5K24 A;  1ECV A;  2QBP A;  2A8B A;  5K9W A;  2I6I A;  3F41 A;  4JMK A;  1PXH A;  2H4V A;  2PBN A;  1PTY A;  4WOH A;  5A5E A;  1I9T A;  3CWE A;  3V0E A;  1LYV A;  1I57 A;  2G59 A;  5HDE A;  1LQF A;  3S4O A;  2CNE A;  3MOZ A;  5EHP A;  4YAA A;  3CM3 A;  2J17 A;  2OZ5 A;  5BX1 A;  2G6Z A;  5IBS A;  3ZM5 A;  1NZ7 A;  2FJN A;  1AAX A;  2I4H A;  1PH0 A;  2PA5 A;  4R0S A;  2WTZ A;  2QCJ A;  2VOS A;  1RPM A;  2C46 A;  2GP0 A;  5AWX A;  1XBO A;  2I4G A;  2Y66 A;  3ZM2 A;  3AWE A;  4TVV A;  4GRY A;  1PA9 A;  2I5X A;  2CM8 A;  4I8N A;  3N0A A;  2VEW A;  2OC3 A;  2B4S A;  3BLU A;  1L8G A;  2JFG A;  3S3K A;  2H03 A;  4RDD A;  1YTW A;  2J16 B;  3QCN A;  4ZN5 A;  1ONY A;  5BZX A;  1YFO A;  2HC1 A;  2F6V A;  2NV5 A;  4R0T A;  3V0J A;  1LAR A;  1D5R A;  3LJ8 A;  2CNH A;  1ONZ A;  2HY3 A;  2NLK A;  4CVK A;  4KI9 A;  4R30 A;  4B04 A;  2XJA A;  1PYN A;  4GFV A;  2B4U A;  2ZMM A;  5M43 A;  1U26 A;  5KA7 A;  1XXP A;  2RF6 A;  1EEO A;  1U25 A;  3QKQ A;  2I3U A;  2WJP A;  4QBW A;  1QZ0 A;  4BUC A;  3F9B A;  1W78 A;  1Q1M A;  3EU0 A;  1G4U S;  1OHD A;  2Q05 A;  2AM2 A;  1FGS A;  5KA0 A;  1FPR A;  1BZH A;  2QEP A;  4NX8 A;  4BPC A;  3A5J A;  3O3L A;  5LXQ B;  4NND A;  2GC5 A;  2B3O A;  3V0I A;  3MMJ A;  4NWF A;  2AHS A;  3D1Q A;  2NT7 A;  3SME A;  2ZN7 A;  1YZ4 A;  1M3G A;  1W7K A;  2J16 A;  3QKP A;  5J8R A;  2PSZ A;  4RI4 A;  1C88 A;  5I6V A;  3QCZ A;  1PA1 A;  3I36 A;  4H1O A;  2VEV A;  3V0D A;  2Y96 A;  4S0G A;  3QCL A;  5KA1 A;  1NWL A;  5KAD A;  4GE2 A;  2FJM A;  2F6Y A;  2PI7 A;  1OET A;  3NME A;  1XXV A;  3SR9 A;  3D9C A;  3I80 A;  2A3K A;  2I4E A;  4GE6 A;  1G4W R;  2QBS A;  4PVG A;  3U96 A;  1ZC0 A;  3ZM1 A;  1MKP A;  2F6W A;  5KA2 A;  4J51 A;  3GXH A;  3QCF A;  4AZ1 A;  3ZMP A;  2ESB A;  2I6O A;  4ZIY A;  2HCM A;  2VTE A;  2JFH A;  3RGQ A;  3ZM6 A;  3QCK A;  1E0D A;  2H02 A;  4ZI4 A;  3EB1 A;  1FPZ A;  2F70 A;  2P6X A;  2F00 A;  2B49 A;  2VTD A;  4RH9 A;  2VEX A;  3QCJ A;  3QCI A;  1C87 A;  4GFU A;  2F6T A;  2I6J A;  5KAA A;  1PTU A;  2PT0 A;  4CVM A;  3V0G A;  1BZJ A;  2XPC A;  4QF5 A;  2BGD A;  2UAG A;  2AZR A;  1C84 A;  3QCD A;  4D3P A;  3F9A A;  2BIJ A;  2HNQ A;  1YWF A;  2Q47 A;  3BRH A;  4OHL A;  1OEM X;  1C85 A;  2CMA A;  4D3Q A;  2E0T A;  1YGR A;  3A5K A;  3RZ2 A;  3ZV2 A;  1YGU A;  1G1G A;  4KYQ A;  2CM3 A;  2M3V A;  1OEO X;  2QBR A;  4RI5 A;  1OEU A;  4KYR A;  4Y2E A;  2DXP A;  1VHR A;  3RO1 A;  5K22 A;  2NT2 A;  4RHG A;  1U24 A;  5BZZ A;  2Y1O A;  2VOR A;  5KA3 A;  1JBV A;  2CFV A;  2CNG A;  3F81 A;  2R0B A;  2GWO A;  4WU3 A;  1XM2 A;  3MOW A;  5KA4 A;  3GXG A;  5KA8 A;  3AWF A;  5KA9 A;  1P31 A;  4OHH A;  4BUB A;  2UUO A;  5GTJ A;  4QDI A;  2QBQ A;  2HC2 A;  1GWZ A;  3N2A A;  2I75 A; 
#chains in the Genus database with same CATH homology
 3D1O A;  1P15 A;  2SHP A;  1A5Y A;  1NWE A;  2CNI A;  3V0H A;  4WU2 A;  4DGX A;  1JLN A;  5K23 A;  1KAV A;  3QCC A;  3S3H A;  2BGE A;  1EEN A;  1PTV A;  1L8K A;  4JNB A;  3OMH A;  4HJP A;  4QUN A;  3S3E A;  3PS5 A;  3D1H A;  4D3R A;  2NTA A;  1SUG A;  4OHE A;  4Y14 A;  1Q6P A;  1C83 A;  2CM2 A;  4Z6B A;  1NNY A;  5BUG A;  2VEU A;  1NL9 A;  5MMZ B;  1KAK A;  3V0F A;  3O4S A;  2VEY A;  1T48 A;  1JF7 A;  2BZL A;  3O5X A;  2F6Z A;  4JMJ A;  1WCH A;  2HVL A;  5IBM A;  4GS0 A;  1QXK A;  4YR8 B;  1ZCK A;  1ZZW A;  1FQ1 A;  4RKK A;  2QDM A;  2F6F A;  2QDP A;  2YDU A;  2HB1 A;  4WTY A;  2PQ5 A;  1NO6 A;  2F71 A;  1T49 A;  2H04 A;  1XRI A;  3QCE A;  1Q6S A;  2C7S A;  2OOQ A;  4ZRT A;  1Q6T A;  2GJT A;  2Y2F A;  3AWG A;  1V3A A;  1YTN A;  2CMB A;  3OLR A;  4IKC A;  2NZ6 A;  4HRF A;  2I3R A;  2CJZ A;  1YTS A;  2JJD A;  4GWF A;  5K9V A;  1OES A;  1YN9 A;  4ERC A;  1BZC A;  2CM7 A;  2IMG A;  3H2X A;  3QCH A;  1WAX A;  1WRM A;  2B4O A;  3EMU A;  5K25 A;  1OHC A;  1J4X A;  1OEV A;  3ZM0 A;  3O4U A;  4DGP A;  1Q6M A;  2B07 A;  3I7Z A;  1G1F A;  2H4K A;  2H4G A;  3QCM A;  2QCT A;  3S3F A;  2FH7 A;  5KAB A;  3EZZ A;  1GFY A;  1I9S A;  2I42 A;  1T4J A;  2OUD A;  4HJQ A;  1OHE A;  2WGP A;  3B7O A;  3BM8 A;  1G1H A;  4ICZ A;  3QCG A;  3D44 A;  3F99 A;  2MBC A;  5EHR A;  4JBC A;  4GRZ A;  1RXD A;  3M4U A;  2I6M A;  3D42 A;  1YPT A;  5KAC A;  4QUM A;  3QCB A;  4NWG A;  4QBE A;  4NYH A;  2F46 A;  1Q6J A;  3ZM3 A;  4QAH A;  1Q6N A;  3S4E A;  2QDC A;  2BV5 A;  2I6P A;  4QAP A;  4OHD A;  1R6H A;  2B4P A;  4RH5 A;  2P4D A;  2CNF A;  1X24 A;  3ZMQ A;  2I1Y A;  2HXP A;  3BLT A;  4GE5 A;  4H34 A;  4PYH A;  1PTT A;  1G7G A;  1ZCL A;  3O4T A;  1G7F A;  4MBB A;  1C86 A;  2CMC A;  4OHI A;  4BJO A;  3EAX A;  3RGO A;  2HNP A;  5K24 A;  1ECV A;  2QBP A;  2A8B A;  5K9W A;  2I6I A;  3F41 A;  4JMK A;  1PXH A;  2H4V A;  2PBN A;  1PTY A;  4WOH A;  1I9T A;  3CWE A;  3V0E A;  1LYV A;  1I57 A;  2G59 A;  5HDE A;  1LQF A;  3S4O A;  2CNE A;  3MOZ A;  5EHP A;  4YAA A;  3CM3 A;  2J17 A;  2OZ5 A;  5BX1 A;  2G6Z A;  5IBS A;  1NZ7 A;  2FJN A;  1AAX A;  2I4H A;  1PH0 A;  2PA5 A;  4R0S A;  2QCJ A;  1RPM A;  2C46 A;  2GP0 A;  5AWX A;  1XBO A;  2I4G A;  3ZM2 A;  3AWE A;  4TVV A;  4GRY A;  1PA9 A;  2I5X A;  2CM8 A;  4I8N A;  3N0A A;  2VEW A;  2OC3 A;  2B4S A;  3BLU A;  1L8G A;  3S3K A;  2H03 A;  4RDD A;  1YTW A;  2J16 B;  3QCN A;  4ZN5 A;  1ONY A;  5BZX A;  1YFO A;  2HC1 A;  2F6V A;  2NV5 A;  4R0T A;  3V0J A;  1LAR A;  1D5R A;  3LJ8 A;  2CNH A;  1ONZ A;  2HY3 A;  2NLK A;  4KI9 A;  4R30 A;  4B04 A;  1PYN A;  4GFV A;  2B4U A;  2ZMM A;  5M43 A;  1U26 A;  5KA7 A;  1XXP A;  2RF6 A;  1EEO A;  1U25 A;  3QKQ A;  2I3U A;  4QBW A;  1QZ0 A;  3F9B A;  1Q1M A;  3EU0 A;  1G4U S;  1OHD A;  2Q05 A;  5KA0 A;  1FPR A;  1BZH A;  2QEP A;  4NX8 A;  4BPC A;  3A5J A;  3O3L A;  5LXQ B;  4NND A;  2B3O A;  3V0I A;  3MMJ A;  4NWF A;  2AHS A;  3D1Q A;  2NT7 A;  3SME A;  2ZN7 A;  1YZ4 A;  1M3G A;  2J16 A;  3QKP A;  5J8R A;  2PSZ A;  4RI4 A;  1C88 A;  5I6V A;  1PA1 A;  3I36 A;  4H1O A;  2VEV A;  3V0D A;  2Y96 A;  4S0G A;  3QCL A;  5KA1 A;  1NWL A;  5KAD A;  4GE2 A;  2FJM A;  2F6Y A;  2PI7 A;  1OET A;  3NME A;  1XXV A;  3SR9 A;  3D9C A;  3I80 A;  2A3K A;  2I4E A;  4GE6 A;  1G4W R;  2QBS A;  4PVG A;  3U96 A;  1ZC0 A;  3ZM1 A;  1MKP A;  2F6W A;  5KA2 A;  4J51 A;  3GXH A;  3QCF A;  4AZ1 A;  3ZMP A;  2ESB A;  2I6O A;  2HCM A;  3RGQ A;  3QCK A;  2H02 A;  4ZI4 A;  3EB1 A;  1FPZ A;  2F70 A;  2P6X A;  2B49 A;  4RH9 A;  2VEX A;  3QCJ A;  3QCI A;  1C87 A;  4GFU A;  2F6T A;  2I6J A;  5KAA A;  1PTU A;  2PT0 A;  3V0G A;  1BZJ A;  2BGD A;  2AZR A;  1C84 A;  3QCD A;  4D3P A;  3F9A A;  2BIJ A;  2HNQ A;  1YWF A;  2Q47 A;  3BRH A;  4OHL A;  1OEM X;  1C85 A;  2CMA A;  4D3Q A;  2E0T A;  1YGR A;  3A5K A;  3RZ2 A;  3ZV2 A;  1YGU A;  1G1G A;  4KYQ A;  2CM3 A;  2M3V A;  1OEO X;  2QBR A;  4RI5 A;  1OEU A;  4KYR A;  4Y2E A;  2DXP A;  1VHR A;  3RO1 A;  5K22 A;  2NT2 A;  4RHG A;  1U24 A;  5BZZ A;  5KA3 A;  2CFV A;  2CNG A;  3F81 A;  2R0B A;  2GWO A;  4WU3 A;  1XM2 A;  3MOW A;  5KA4 A;  3GXG A;  5KA8 A;  3AWF A;  5KA9 A;  4OHH A;  5GTJ A;  2QBQ A;  2HC2 A;  1GWZ A;  2I75 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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