1NNYA

Potent, selective protein tyrosine phosphatase 1b inhibitor compound 23 using a linked-fragment strategy
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
282
structure length
282
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Protein-tyrosine phosphatase, non-receptor type 1
total genus 92
structure length 282
sequence length 282
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2003-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 1nnyA00
1C88A 3V0GA 4D3QA 1WCHA 3RZ2A 4DGPA 1ZCKA 4GE5A 3RO1A 2BIJA 2I4EA 1WAXA 2B3OA 4RH5A 4QAHA 1EENA 3OLRA 1D5RA 2H4KA 5KACA 1ZZWA 3D1OA 1T4JA 5GTJA 4D3RA 5BUGA 1GFYA 1X24A 2CNFA 4RI5A 3D1HA 2H04A 3MOZA 4GWFA 5IBMA 1Q6JA 3EZZA 2BGDA 1OEUA 3RGOA 2BV5A 3S3FA 4NWGA 1YTWA 1L8GA 1Q6NA 3O5XA 2NT7A 3ZMQA 5KA8A 2A8BA 2VEXA 2B4OA 1OEVA 1ONZA 2HNPA 2I6MA 3A5KA 2Q05A 2IMGA 2B4UA 4RHGA 3BRHA 4I8NA 4Z6BA 2R0BA 3D44A 2VEWA 3EB1A 3D1QA 4GE2A 1JLNA 4KYQA 2F6FA 3S4EA 4RH9A 1YTSA 2WGPA 2Q47A 2FJNA 2PT0A 3EMUA 2CM3A 1YWFA 1V3AA 1LYVA 2QCJA 5KA4A 2RF6A 1KAVA 2BZLA 1YZ4A 3CWEA 2NV5A 3N0AA 4NNDA 4OHLA 4Y2EA 1PYNA 5K23A 2QBPA 1J4XA 2I5XA 4RI4A 1PTTA 2I6IA 4GRYA 3D9CA 2QDMA 4D3PA 5MMZB 2OUDA 1XXVA 1OEMX 3F9BA 2HCMA 3AWEA 2F6YA 3SR9A 3BLTA 3QCCA 1RPMA 2JJDA 3I80A 1G7GA 2I4GA 4ZRTA 4BJOA 1C86A 1BZJA 5HDEA 2QBRA 4JBCA 4H1OA 2YDUA 2CMCA 1G4US 2PBNA 2J16B 2I6OA 1SUGA 2QDPA 4OHHA 1P15A 4GS0A 4QBEA 1ZCLA 4J51A 1G4WR 1C85A 3I36A 1Q1MA 1ONYA 2NT2A 1XXPA 2I4HA 1C84A 4NWFA 2F6VA 2PSZA 1PH0A 4PYHA 1JF7A 3ZM1A 5K9VA 5IBSA 3S3HA 2ZN7A 2OZ5A 1XBOA 4KYRA 4RDDA 3QCMA 1PTUA 4ZN5A 2CNGA 1U24A 3RGQA 4MBBA 4QUNA 3V0JA 5BZZA 2QBSA 4ERCA 1BZCA 1LQFA 1RXDA 5KA1A 1YTNA 2NTAA 3SMEA 4WU2A 2B07A 3PS5A 2HC2A 4R30A 4R0TA 1YN9A 3S3EA 5KA2A 2ZMMA 1G1GA 2P4DA 4OHIA 1BZHA 2QBQA 3EAXA 1PTYA 2AHSA 1VHRA 3EU0A 3CM3A 1AAXA 2OOQA 1NWEA 4TVVA 3GXHA 2I6PA 1YPTA 5KA3A 3D42A 3M4UA 2CJZA 5EHRA 4OHDA 2H4VA 1QZ0A 3AWFA 5KA9A 4WTYA 3MMJA 1C87A 4WOHA 1ZC0A 2F6WA 1R6HA 3NMEA 1NZ7A 2FH7A 2MBCA 3QCBA 3AWGA 2F46A 4S0GA 1GWZA 1A5YA 2B49A 3F99A 1OHEA 3F41A 3O4UA 2CM7A 3O4TA 1FQ1A 2NLKA 3QCJA 2HNQA 3ZV2A 2CMAA 1NNYA 1Q6SA 1T48A 3V0IA 5KA0A 4QAPA 3QCLA 2HC1A 4YR8B 4GFVA 1LARA 1Q6MA 2I3RA 4NYHA 5K9WA 3OMHA 5KA7A 1PXHA 2B4SA 2OC3A 2J16A 2G59A 3GXGA 4GRZA 3LJ8A 3V0FA 1I57A 2CNEA 5J8RA 2PI7A 1G7FA 2F6TA 3QCNA 3QCEA 4NX8A 2I75A 2DXPA 1Q6TA 2HVLA 5K22A 4ICZA 5KAAA 5AWXA 1NWLA 5BX1A 2CM8A 1OEOX 2H4GA 2Y2FA 2E0TA 1OHDA 2BGEA 2HXPA 1XRIA 4ZI4A 3QCHA 1Q6PA 3ZM0A 2M3VA 2CNHA 2I3UA 5LXQB 1PA1A 2VEVA 2H03A 4JMJA 3QCFA 2FJMA 2PA5A 1FPZA 2ESBA 4Y14A 1I9TA 2SHPA 1YGRA 3B7OA 4R0SA 2Y96A 3O3LA 1M3GA 3ZM3A 2CNIA 4WU3A 1YFOA 3A5JA 4AZ1A 2VEYA 2GJTA 4KI9A 2NZ6A 3BM8A 5K24A 5K25A 2F70A 4QUMA 1C83A 1FPRA 2P6XA 3QKQA 2PQ5A 5M43A 1PTVA 1KAKA 4DGXA 1NO6A 1MKPA 4OHEA 4HJPA 3V0EA 2A3KA 2HY3A 3V0HA 4BPCA 3QCGA 3V0DA 1PA9A 2F71A 1NL9A 4HJQA 2B4PA 3F81A 2F6ZA 2I42A 2C7SA 1L8KA 2GP0A 2AZRA 1U26A 2HB1A 3I7ZA 4QBWA 1G1HA 5I6VA 1ECVA 4JNBA 3S4OA 1QXKA 5KADA 2C46A 2CFVA 5EHPA 3F9AA 2VEUA 5BZXA 2CM2A 2I6JA 2J17A 4B04A 1OESA 3QCDA 3MOWA 3ZM2A 1YGUA 3ZMPA 3QCIA 2G6ZA 1G1FA 4RKKA 2CMBA 2QDCA 4H34A 3H2XA 1WRMA 2I1YA 2QEPA 4YAAA 3QCKA 2H02A 3QKPA 1T49A 4PVGA 4JMKA 2GWOA 5KABA 1OHCA 3S3KA 4GE6A 1OETA 1U25A 4IKCA 1I9SA 3U96A 1EEOA 2QCTA 3O4SA 4HRFA 1XM2A 3BLUA 4GFUA
chains in the Genus database with same CATH superfamily
1C88A 3V0GA 4D3QA 1WCHA 3RZ2A 4DGPA 1ZCKA 4GE5A 3RO1A 3ZL8A 2BIJA 2I4EA 1E8CA 4QDIA 1WAXA 2B3OA 4RH5A 4QAHA 1EENA 3OLRA 1D5RA 2H4KA 5KACA 1ZZWA 3D1OA 1T4JA 2Y66A 5GTJA 4D3RA 5BUGA 1GFYA 1X24A 2CNFA 4RI5A 3D1HA 2H04A 3MOZA 4GWFA 1EEHA 5IBMA 1Q6JA 3EZZA 2BGDA 1OEUA 3RGOA 2BV5A 3S3FA 4NWGA 2UAGA 1YTWA 1L8GA 1Q6NA 3O5XA 2NT7A 3ZMQA 5KA8A 2A8BA 2VEXA 2B4OA 1OEVA 1JBWA 1ONZA 2HNPA 2I6MA 3A5KA 2Q05A 2IMGA 2B4UA 4RHGA 3BRHA 4I8NA 4Z6BA 2R0BA 3D44A 2VEWA 3EB1A 3D1QA 4GE2A 1JLNA 2VTEA 2F6FA 4KYQA 3S4EA 4RH9A 1YTSA 2WGPA 2Q47A 1GQQA 2FJNA 2PT0A 3EMUA 2CM3A 1YWFA 1V3AA 1LYVA 2QCJA 5KA4A 2RF6A 1KAVA 2BZLA 5A5FA 1YZ4A 3CWEA 2NV5A 3N0AA 4NNDA 4OHLA 4C13A 4Y2EA 1GG4A 1PYNA 5K23A 2QBPA 1J4XA 2I5XA 4HV4A 4RI4A 1PTTA 2I6IA 4GRYA 2Y67A 3D9CA 2QDMA 4D3PA 5MMZB 2OUDA 1XXVA 1OEMX 1O5ZA 3F9BA 2HCMA 3AWEA 2F6YA 3SR9A 3BLTA 3QCCA 1RPMA 2JJDA 3I80A 1G7GA 2I4GA 4ZRTA 4BJOA 1C86A 2VTDA 1BZJA 5HDEA 1W78A 2QBRA 4JBCA 4H1OA 2YDUA 2CMCA 1G4US 2VOSA 2PBNA 2J16B 2I6OA 1SUGA 2QDPA 2Y1OA 1P15A 4OHHA 4GS0A 4QBEA 1ZCLA 4J51A 1G4WR 2GC6A 1C85A 3I36A 1Q1MA 1ONYA 2NT2A 1XXPA 2I4HA 1C84A 4NWFA 2F6VA 2PSZA 1PH0A 4PYHA 1JF7A 3ZM1A 5K9VA 5IBSA 3S3HA 1J6UA 2ZN7A 2OZ5A 1XBOA 4KYRA 3MVNA 4RDDA 3QCMA 4BUCA 1PTUA 4ZN5A 2CNGA 1U24A 1JBVA 3RGQA 4MBBA 4QUNA 3V0JA 5BZZA 2QBSA 4ERCA 1BZCA 1LQFA 1RXDA 5KA1A 1YTNA 4ZIYA 2NTAA 3SMEA 2F00A 4WU2A 2B07A 3PS5A 2HC2A 4R30A 4R0TA 1YN9A 4CVMA 3S3EA 5KA2A 2ZMMA 1G1GA 2P4DA 4OHIA 1BZHA 2QBQA 3EAXA 2XJAA 2JFFA 1PTYA 2AHSA 1VHRA 3EU0A 3CM3A 3ZM5A 1AAXA 2WTZA 2OOQA 1NWEA 4TVVA 3GXHA 2I6PA 5A5EA 1YPTA 5KA3A 3D42A 3M4UA 1W7KA 2CJZA 5EHRA 4OHDA 2H4VA 1QZ0A 3AWFA 5KA9A 4WTYA 3MMJA 1C87A 4WOHA 1ZC0A 2F6WA 1R6HA 3NMEA 1NZ7A 1P3DA 2FH7A 2MBCA 3QCBA 3AWGA 2F46A 4S0GA 1GWZA 3UAGA 1A5YA 2B49A 3F99A 1OHEA 3F41A 3O4UA 2CM7A 3O4TA 1FQ1A 2NLKA 3QCJA 2HNQA 3ZV2A 2CMAA 1NNYA 1Q6SA 2XPCA 1T48A 3V0IA 5KA0A 4QAPA 3QCLA 2HC1A 4YR8B 4GFVA 1LARA 1Q6MA 2I3RA 3LK7A 4NYHA 5K9WA 3PYZA 3OMHA 5KA7A 1PXHA 2B4SA 2OC3A 2J16A 2G59A 3GXGA 4GRZA 2GC5A 4C12A 3LJ8A 3V0FA 1I57A 2CNEA 5J8RA 2PI7A 1G7FA 2F6TA 3QCNA 2VORA 3QCEA 1E0DA 4NX8A 2I75A 2DXPA 1Q6TA 2HVLA 5K22A 4ICZA 5KAAA 5AWXA 1NWLA 2GCBA 5BX1A 2CM8A 1OEOX 2H4GA 2Y2FA 2E0TA 1OHDA 2BGEA 2HXPA 3NRSA 1XRIA 4ZI4A 3QCHA 1Q6PA 3ZM0A 2M3VA 2CNHA 4UAGA 2I3UA 5LXQB 2AM1A 1PA1A 2VEVA 2H03A 4JMJA 2GCAA 3QCFA 2FJMA 2PA5A 1FPZA 2ESBA 4Y14A 1I9TA 2WJPA 4QF5A 2SHPA 1YGRA 3B7OA 4R0SA 4CVLA 2Y96A 3O3LA 1M3GA 3ZM3A 2X5OA 2CNIA 4WU3A 1YFOA 3A5JA 4AZ1A 2VEYA 2GJTA 4KI9A 2NZ6A 3BM8A 5K24A 5K25A 2F70A 4QUMA 1C83A 1FPRA 2P6XA 1P31A 3QKQA 2PQ5A 5M43A 1PTVA 1KAKA 4DGXA 1NO6A 1MKPA 4OHEA 2UUOA 4HJPA 3V0EA 2A3KA 2HY3A 3V0HA 4BPCA 3QCGA 3V0DA 1PA9A 2F71A 4CVKA 1NL9A 4HJQA 1UAGA 2B4PA 2Y68A 1FGSA 3F81A 2F6ZA 2I42A 1GQYA 2C7SA 2UUPA 1L8KA 2GP0A 2AZRA 1U26A 2HB1A 3N2AA 3I7ZA 4QBWA 1G1HA 5I6VA 1ECVA 4JNBA 3S4OA 1QXKA 5KADA 2C46A 2CFVA 3ZM6A 5EHPA 3F9AA 2VEUA 5BZXA 3QCZA 2CM2A 2I6JA 2J17A 2JFHA 3HN7A 4B04A 4BUBA 2JFGA 1OESA 3QCDA 3MOWA 3ZM2A 1YGUA 3ZMPA 3QCIA 2G6ZA 1G1FA 4RKKA 2CMBA 2QDCA 4H34A 3H2XA 1WRMA 2I1YA 2QEPA 4YAAA 3QCKA 2H02A 3QKPA 1T49A 4PVGA 4JMKA 2GWOA 5KABA 1OHCA 3S3KA 4GE6A 1OETA 1U25A 4IKCA 1I9SA 3U96A 1EEOA 2QCTA 3O4SA 4HRFA 2AM2A 1XM2A 3BLUA 4GFUA
chains in the Genus database with same CATH topology
1C88A 3V0GA 4D3QA 1WCHA 3RZ2A 4DGPA 1ZCKA 4GE5A 3RO1A 2BIJA 2I4EA 1WAXA 2B3OA 4RH5A 4QAHA 1EENA 3OLRA 1D5RA 2H4KA 5KACA 1ZZWA 3D1OA 1T4JA 5GTJA 4D3RA 5BUGA 1GFYA 1X24A 2CNFA 4RI5A 3D1HA 2H04A 3MOZA 4GWFA 5IBMA 1Q6JA 3EZZA 2BGDA 1OEUA 3RGOA 2BV5A 3S3FA 4NWGA 1YTWA 1L8GA 1Q6NA 3O5XA 2NT7A 3ZMQA 5KA8A 2A8BA 2VEXA 2B4OA 1OEVA 1ONZA 2HNPA 2I6MA 3A5KA 2Q05A 2IMGA 2B4UA 4RHGA 3BRHA 4I8NA 4Z6BA 2R0BA 3D44A 2VEWA 3EB1A 3D1QA 4GE2A 1JLNA 4KYQA 2F6FA 3S4EA 4RH9A 1YTSA 2WGPA 2Q47A 2FJNA 2PT0A 3EMUA 2CM3A 1YWFA 1V3AA 1LYVA 2QCJA 5KA4A 2RF6A 1KAVA 2BZLA 1YZ4A 3CWEA 2NV5A 3N0AA 4NNDA 4OHLA 4Y2EA 1PYNA 5K23A 2QBPA 1J4XA 2I5XA 4RI4A 1PTTA 2I6IA 4GRYA 3D9CA 2QDMA 4D3PA 5MMZB 2OUDA 1XXVA 1OEMX 3F9BA 2HCMA 3AWEA 2F6YA 3SR9A 3BLTA 3QCCA 1RPMA 2JJDA 3I80A 1G7GA 2I4GA 4ZRTA 4BJOA 1C86A 1BZJA 5HDEA 2QBRA 4JBCA 4H1OA 2YDUA 2CMCA 1G4US 2PBNA 2J16B 2I6OA 1SUGA 2QDPA 4OHHA 1P15A 4GS0A 4QBEA 1ZCLA 4J51A 1G4WR 1C85A 3I36A 1Q1MA 1ONYA 2NT2A 1XXPA 2I4HA 1C84A 4NWFA 2F6VA 2PSZA 1PH0A 4PYHA 1JF7A 3ZM1A 5K9VA 5IBSA 3S3HA 2ZN7A 2OZ5A 1XBOA 4KYRA 4RDDA 3QCMA 1PTUA 4ZN5A 2CNGA 1U24A 3RGQA 4MBBA 4QUNA 3V0JA 5BZZA 2QBSA 4ERCA 1BZCA 1LQFA 1RXDA 5KA1A 1YTNA 2NTAA 3SMEA 4WU2A 2B07A 3PS5A 2HC2A 4R30A 4R0TA 1YN9A 3S3EA 5KA2A 2ZMMA 1G1GA 2P4DA 4OHIA 1BZHA 2QBQA 3EAXA 1PTYA 2AHSA 1VHRA 3EU0A 3CM3A 1AAXA 2OOQA 1NWEA 4TVVA 3GXHA 2I6PA 1YPTA 5KA3A 3D42A 3M4UA 2CJZA 5EHRA 4OHDA 2H4VA 1QZ0A 3AWFA 5KA9A 4WTYA 3MMJA 1C87A 4WOHA 1ZC0A 2F6WA 1R6HA 3NMEA 1NZ7A 2FH7A 2MBCA 3QCBA 3AWGA 2F46A 4S0GA 1GWZA 1A5YA 2B49A 3F99A 1OHEA 3F41A 3O4UA 2CM7A 3O4TA 1FQ1A 2NLKA 3QCJA 2HNQA 3ZV2A 2CMAA 1NNYA 1Q6SA 1T48A 3V0IA 5KA0A 4QAPA 3QCLA 2HC1A 4YR8B 4GFVA 1LARA 1Q6MA 2I3RA 4NYHA 5K9WA 3OMHA 5KA7A 1PXHA 2B4SA 2OC3A 2J16A 2G59A 3GXGA 4GRZA 3LJ8A 3V0FA 1I57A 2CNEA 5J8RA 2PI7A 1G7FA 2F6TA 3QCNA 3QCEA 4NX8A 2I75A 2DXPA 1Q6TA 2HVLA 5K22A 4ICZA 5KAAA 5AWXA 1NWLA 5BX1A 2CM8A 1OEOX 2H4GA 2Y2FA 2E0TA 1OHDA 2BGEA 2HXPA 1XRIA 4ZI4A 3QCHA 1Q6PA 3ZM0A 2M3VA 2CNHA 2I3UA 5LXQB 1PA1A 2VEVA 2H03A 4JMJA 3QCFA 2FJMA 2PA5A 1FPZA 2ESBA 4Y14A 1I9TA 2SHPA 1YGRA 3B7OA 4R0SA 2Y96A 3O3LA 1M3GA 3ZM3A 2CNIA 4WU3A 1YFOA 3A5JA 4AZ1A 2VEYA 2GJTA 4KI9A 2NZ6A 3BM8A 5K24A 5K25A 2F70A 4QUMA 1C83A 1FPRA 2P6XA 3QKQA 2PQ5A 5M43A 1PTVA 1KAKA 4DGXA 1NO6A 1MKPA 4OHEA 4HJPA 3V0EA 2A3KA 2HY3A 3V0HA 4BPCA 3QCGA 3V0DA 1PA9A 2F71A 1NL9A 4HJQA 2B4PA 3F81A 2F6ZA 2I42A 2C7SA 1L8KA 2GP0A 2AZRA 1U26A 2HB1A 3I7ZA 4QBWA 1G1HA 5I6VA 1ECVA 4JNBA 3S4OA 1QXKA 5KADA 2C46A 2CFVA 5EHPA 3F9AA 2VEUA 5BZXA 2CM2A 2I6JA 2J17A 4B04A 1OESA 3QCDA 3MOWA 3ZM2A 1YGUA 3ZMPA 3QCIA 2G6ZA 1G1FA 4RKKA 2CMBA 2QDCA 4H34A 3H2XA 1WRMA 2I1YA 2QEPA 4YAAA 3QCKA 2H02A 3QKPA 1T49A 4PVGA 4JMKA 2GWOA 5KABA 1OHCA 3S3KA 4GE6A 1OETA 1U25A 4IKCA 1I9SA 3U96A 1EEOA 2QCTA 3O4SA 4HRFA 1XM2A 3BLUA 4GFUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C88 A;  3V0G A;  4D3Q A;  1WCH A;  3RZ2 A;  4DGP A;  1ZCK A;  4GE5 A;  3RO1 A;  2BIJ A;  2I4E A;  1WAX A;  2B3O A;  4RH5 A;  4QAH A;  1EEN A;  3OLR A;  1D5R A;  2H4K A;  5KAC A;  1ZZW A;  3D1O A;  1T4J A;  5GTJ A;  4D3R A;  5BUG A;  1GFY A;  1X24 A;  2CNF A;  4RI5 A;  3D1H A;  2H04 A;  3MOZ A;  4GWF A;  5IBM A;  1Q6J A;  3EZZ A;  2BGD A;  1OEU A;  3RGO A;  2BV5 A;  3S3F A;  4NWG A;  1YTW A;  1L8G A;  1Q6N A;  3O5X A;  2NT7 A;  3ZMQ A;  5KA8 A;  2A8B A;  2VEX A;  2B4O A;  1OEV A;  1ONZ A;  2HNP A;  2I6M A;  3A5K A;  2Q05 A;  2IMG A;  2B4U A;  4RHG A;  3BRH A;  4I8N A;  4Z6B A;  2R0B A;  3D44 A;  2VEW A;  3EB1 A;  3D1Q A;  4GE2 A;  1JLN A;  4KYQ A;  2F6F A;  3S4E A;  4RH9 A;  1YTS A;  2WGP A;  2Q47 A;  2FJN A;  2PT0 A;  3EMU A;  2CM3 A;  1YWF A;  1V3A A;  1LYV A;  2QCJ A;  5KA4 A;  2RF6 A;  1KAV A;  2BZL A;  1YZ4 A;  3CWE A;  2NV5 A;  3N0A A;  4NND A;  4OHL A;  4Y2E A;  1PYN A;  5K23 A;  2QBP A;  1J4X A;  2I5X A;  4RI4 A;  1PTT A;  2I6I A;  4GRY A;  3D9C A;  2QDM A;  4D3P A;  5MMZ B;  2OUD A;  1XXV A;  1OEM X;  3F9B A;  2HCM A;  3AWE A;  2F6Y A;  3SR9 A;  3BLT A;  3QCC A;  1RPM A;  2JJD A;  3I80 A;  1G7G A;  2I4G A;  4ZRT A;  4BJO A;  1C86 A;  1BZJ A;  5HDE A;  2QBR A;  4JBC A;  4H1O A;  2YDU A;  2CMC A;  1G4U S;  2PBN A;  2J16 B;  2I6O A;  1SUG A;  2QDP A;  4OHH A;  1P15 A;  4GS0 A;  4QBE A;  1ZCL A;  4J51 A;  1G4W R;  1C85 A;  3I36 A;  1Q1M A;  1ONY A;  2NT2 A;  1XXP A;  2I4H A;  1C84 A;  4NWF A;  2F6V A;  2PSZ A;  1PH0 A;  4PYH A;  1JF7 A;  3ZM1 A;  5K9V A;  5IBS A;  3S3H A;  2ZN7 A;  2OZ5 A;  1XBO A;  4KYR A;  4RDD A;  3QCM A;  1PTU A;  4ZN5 A;  2CNG A;  1U24 A;  3RGQ A;  4MBB A;  4QUN A;  3V0J A;  5BZZ A;  2QBS A;  4ERC A;  1BZC A;  1LQF A;  1RXD A;  5KA1 A;  1YTN A;  2NTA A;  3SME A;  4WU2 A;  2B07 A;  3PS5 A;  2HC2 A;  4R30 A;  4R0T A;  1YN9 A;  3S3E A;  5KA2 A;  2ZMM A;  1G1G A;  2P4D A;  4OHI A;  1BZH A;  2QBQ A;  3EAX A;  1PTY A;  2AHS A;  1VHR A;  3EU0 A;  3CM3 A;  1AAX A;  2OOQ A;  1NWE A;  4TVV A;  3GXH A;  2I6P A;  1YPT A;  5KA3 A;  3D42 A;  3M4U A;  2CJZ A;  5EHR A;  4OHD A;  2H4V A;  1QZ0 A;  3AWF A;  5KA9 A;  4WTY A;  3MMJ A;  1C87 A;  4WOH A;  1ZC0 A;  2F6W A;  1R6H A;  3NME A;  1NZ7 A;  2FH7 A;  2MBC A;  3QCB A;  3AWG A;  2F46 A;  4S0G A;  1GWZ A;  1A5Y A;  2B49 A;  3F99 A;  1OHE A;  3F41 A;  3O4U A;  2CM7 A;  3O4T A;  1FQ1 A;  2NLK A;  3QCJ A;  2HNQ A;  3ZV2 A;  2CMA A;  1NNY A;  1Q6S A;  1T48 A;  3V0I A;  5KA0 A;  4QAP A;  3QCL A;  2HC1 A;  4YR8 B;  4GFV A;  1LAR A;  1Q6M A;  2I3R A;  4NYH A;  5K9W A;  3OMH A;  5KA7 A;  1PXH A;  2B4S A;  2OC3 A;  2J16 A;  2G59 A;  3GXG A;  4GRZ A;  3LJ8 A;  3V0F A;  1I57 A;  2CNE A;  5J8R A;  2PI7 A;  1G7F A;  2F6T A;  3QCN A;  3QCE A;  4NX8 A;  2I75 A;  2DXP A;  1Q6T A;  2HVL A;  5K22 A;  4ICZ A;  5KAA A;  5AWX A;  1NWL A;  5BX1 A;  2CM8 A;  1OEO X;  2H4G A;  2Y2F A;  2E0T A;  1OHD A;  2BGE A;  2HXP A;  1XRI A;  4ZI4 A;  3QCH A;  1Q6P A;  3ZM0 A;  2M3V A;  2CNH A;  2I3U A;  5LXQ B;  1PA1 A;  2VEV A;  2H03 A;  4JMJ A;  3QCF A;  2FJM A;  2PA5 A;  1FPZ A;  2ESB A;  4Y14 A;  1I9T A;  2SHP A;  1YGR A;  3B7O A;  4R0S A;  2Y96 A;  3O3L A;  1M3G A;  3ZM3 A;  2CNI A;  4WU3 A;  1YFO A;  3A5J A;  4AZ1 A;  2VEY A;  2GJT A;  4KI9 A;  2NZ6 A;  3BM8 A;  5K24 A;  5K25 A;  2F70 A;  4QUM A;  1C83 A;  1FPR A;  2P6X A;  3QKQ A;  2PQ5 A;  5M43 A;  1PTV A;  1KAK A;  4DGX A;  1NO6 A;  1MKP A;  4OHE A;  4HJP A;  3V0E A;  2A3K A;  2HY3 A;  3V0H A;  4BPC A;  3QCG A;  3V0D A;  1PA9 A;  2F71 A;  1NL9 A;  4HJQ A;  2B4P A;  3F81 A;  2F6Z A;  2I42 A;  2C7S A;  1L8K A;  2GP0 A;  2AZR A;  1U26 A;  2HB1 A;  3I7Z A;  4QBW A;  1G1H A;  5I6V A;  1ECV A;  4JNB A;  3S4O A;  1QXK A;  5KAD A;  2C46 A;  2CFV A;  5EHP A;  3F9A A;  2VEU A;  5BZX A;  2CM2 A;  2I6J A;  2J17 A;  4B04 A;  1OES A;  3QCD A;  3MOW A;  3ZM2 A;  1YGU A;  3ZMP A;  3QCI A;  2G6Z A;  1G1F A;  4RKK A;  2CMB A;  2QDC A;  4H34 A;  3H2X A;  1WRM A;  2I1Y A;  2QEP A;  4YAA A;  3QCK A;  2H02 A;  3QKP A;  1T49 A;  4PVG A;  4JMK A;  2GWO A;  5KAB A;  1OHC A;  3S3K A;  4GE6 A;  1OET A;  1U25 A;  4IKC A;  1I9S A;  3U96 A;  1EEO A;  2QCT A;  3O4S A;  4HRF A;  1XM2 A;  3BLU A;  4GFU A; 
#chains in the Genus database with same CATH topology
 1C88 A;  3V0G A;  4D3Q A;  1WCH A;  3RZ2 A;  4DGP A;  1ZCK A;  4GE5 A;  3RO1 A;  3ZL8 A;  2BIJ A;  2I4E A;  1E8C A;  4QDI A;  1WAX A;  2B3O A;  4RH5 A;  4QAH A;  1EEN A;  3OLR A;  1D5R A;  2H4K A;  5KAC A;  1ZZW A;  3D1O A;  1T4J A;  2Y66 A;  5GTJ A;  4D3R A;  5BUG A;  1GFY A;  1X24 A;  2CNF A;  4RI5 A;  3D1H A;  2H04 A;  3MOZ A;  4GWF A;  1EEH A;  5IBM A;  1Q6J A;  3EZZ A;  2BGD A;  1OEU A;  3RGO A;  2BV5 A;  3S3F A;  4NWG A;  2UAG A;  1YTW A;  1L8G A;  1Q6N A;  3O5X A;  2NT7 A;  3ZMQ A;  5KA8 A;  2A8B A;  2VEX A;  2B4O A;  1OEV A;  1JBW A;  1ONZ A;  2HNP A;  2I6M A;  3A5K A;  2Q05 A;  2IMG A;  2B4U A;  4RHG A;  3BRH A;  4I8N A;  4Z6B A;  2R0B A;  3D44 A;  2VEW A;  3EB1 A;  3D1Q A;  4GE2 A;  1JLN A;  2VTE A;  2F6F A;  4KYQ A;  3S4E A;  4RH9 A;  1YTS A;  2WGP A;  2Q47 A;  1GQQ A;  2FJN A;  2PT0 A;  3EMU A;  2CM3 A;  1YWF A;  1V3A A;  1LYV A;  2QCJ A;  5KA4 A;  2RF6 A;  1KAV A;  2BZL A;  5A5F A;  1YZ4 A;  3CWE A;  2NV5 A;  3N0A A;  4NND A;  4OHL A;  4C13 A;  4Y2E A;  1GG4 A;  1PYN A;  5K23 A;  2QBP A;  1J4X A;  2I5X A;  4HV4 A;  4RI4 A;  1PTT A;  2I6I A;  4GRY A;  2Y67 A;  3D9C A;  2QDM A;  4D3P A;  5MMZ B;  2OUD A;  1XXV A;  1OEM X;  1O5Z A;  3F9B A;  2HCM A;  3AWE A;  2F6Y A;  3SR9 A;  3BLT A;  3QCC A;  1RPM A;  2JJD A;  3I80 A;  1G7G A;  2I4G A;  4ZRT A;  4BJO A;  1C86 A;  2VTD A;  1BZJ A;  5HDE A;  1W78 A;  2QBR A;  4JBC A;  4H1O A;  2YDU A;  2CMC A;  1G4U S;  2VOS A;  2PBN A;  2J16 B;  2I6O A;  1SUG A;  2QDP A;  2Y1O A;  1P15 A;  4OHH A;  4GS0 A;  4QBE A;  1ZCL A;  4J51 A;  1G4W R;  2GC6 A;  1C85 A;  3I36 A;  1Q1M A;  1ONY A;  2NT2 A;  1XXP A;  2I4H A;  1C84 A;  4NWF A;  2F6V A;  2PSZ A;  1PH0 A;  4PYH A;  1JF7 A;  3ZM1 A;  5K9V A;  5IBS A;  3S3H A;  1J6U A;  2ZN7 A;  2OZ5 A;  1XBO A;  4KYR A;  3MVN A;  4RDD A;  3QCM A;  4BUC A;  1PTU A;  4ZN5 A;  2CNG A;  1U24 A;  1JBV A;  3RGQ A;  4MBB A;  4QUN A;  3V0J A;  5BZZ A;  2QBS A;  4ERC A;  1BZC A;  1LQF A;  1RXD A;  5KA1 A;  1YTN A;  4ZIY A;  2NTA A;  3SME A;  2F00 A;  4WU2 A;  2B07 A;  3PS5 A;  2HC2 A;  4R30 A;  4R0T A;  1YN9 A;  4CVM A;  3S3E A;  5KA2 A;  2ZMM A;  1G1G A;  2P4D A;  4OHI A;  1BZH A;  2QBQ A;  3EAX A;  2XJA A;  2JFF A;  1PTY A;  2AHS A;  1VHR A;  3EU0 A;  3CM3 A;  3ZM5 A;  1AAX A;  2WTZ A;  2OOQ A;  1NWE A;  4TVV A;  3GXH A;  2I6P A;  5A5E A;  1YPT A;  5KA3 A;  3D42 A;  3M4U A;  1W7K A;  2CJZ A;  5EHR A;  4OHD A;  2H4V A;  1QZ0 A;  3AWF A;  5KA9 A;  4WTY A;  3MMJ A;  1C87 A;  4WOH A;  1ZC0 A;  2F6W A;  1R6H A;  3NME A;  1NZ7 A;  1P3D A;  2FH7 A;  2MBC A;  3QCB A;  3AWG A;  2F46 A;  4S0G A;  1GWZ A;  3UAG A;  1A5Y A;  2B49 A;  3F99 A;  1OHE A;  3F41 A;  3O4U A;  2CM7 A;  3O4T A;  1FQ1 A;  2NLK A;  3QCJ A;  2HNQ A;  3ZV2 A;  2CMA A;  1NNY A;  1Q6S A;  2XPC A;  1T48 A;  3V0I A;  5KA0 A;  4QAP A;  3QCL A;  2HC1 A;  4YR8 B;  4GFV A;  1LAR A;  1Q6M A;  2I3R A;  3LK7 A;  4NYH A;  5K9W A;  3PYZ A;  3OMH A;  5KA7 A;  1PXH A;  2B4S A;  2OC3 A;  2J16 A;  2G59 A;  3GXG A;  4GRZ A;  2GC5 A;  4C12 A;  3LJ8 A;  3V0F A;  1I57 A;  2CNE A;  5J8R A;  2PI7 A;  1G7F A;  2F6T A;  3QCN A;  2VOR A;  3QCE A;  1E0D A;  4NX8 A;  2I75 A;  2DXP A;  1Q6T A;  2HVL A;  5K22 A;  4ICZ A;  5KAA A;  5AWX A;  1NWL A;  2GCB A;  5BX1 A;  2CM8 A;  1OEO X;  2H4G A;  2Y2F A;  2E0T A;  1OHD A;  2BGE A;  2HXP A;  3NRS A;  1XRI A;  4ZI4 A;  3QCH A;  1Q6P A;  3ZM0 A;  2M3V A;  2CNH A;  4UAG A;  2I3U A;  5LXQ B;  2AM1 A;  1PA1 A;  2VEV A;  2H03 A;  4JMJ A;  2GCA A;  3QCF A;  2FJM A;  2PA5 A;  1FPZ A;  2ESB A;  4Y14 A;  1I9T A;  2WJP A;  4QF5 A;  2SHP A;  1YGR A;  3B7O A;  4R0S A;  4CVL A;  2Y96 A;  3O3L A;  1M3G A;  3ZM3 A;  2X5O A;  2CNI A;  4WU3 A;  1YFO A;  3A5J A;  4AZ1 A;  2VEY A;  2GJT A;  4KI9 A;  2NZ6 A;  3BM8 A;  5K24 A;  5K25 A;  2F70 A;  4QUM A;  1C83 A;  1FPR A;  2P6X A;  1P31 A;  3QKQ A;  2PQ5 A;  5M43 A;  1PTV A;  1KAK A;  4DGX A;  1NO6 A;  1MKP A;  4OHE A;  2UUO A;  4HJP A;  3V0E A;  2A3K A;  2HY3 A;  3V0H A;  4BPC A;  3QCG A;  3V0D A;  1PA9 A;  2F71 A;  4CVK A;  1NL9 A;  4HJQ A;  1UAG A;  2B4P A;  2Y68 A;  1FGS A;  3F81 A;  2F6Z A;  2I42 A;  1GQY A;  2C7S A;  2UUP A;  1L8K A;  2GP0 A;  2AZR A;  1U26 A;  2HB1 A;  3N2A A;  3I7Z A;  4QBW A;  1G1H A;  5I6V A;  1ECV A;  4JNB A;  3S4O A;  1QXK A;  5KAD A;  2C46 A;  2CFV A;  3ZM6 A;  5EHP A;  3F9A A;  2VEU A;  5BZX A;  3QCZ A;  2CM2 A;  2I6J A;  2J17 A;  2JFH A;  3HN7 A;  4B04 A;  4BUB A;  2JFG A;  1OES A;  3QCD A;  3MOW A;  3ZM2 A;  1YGU A;  3ZMP A;  3QCI A;  2G6Z A;  1G1F A;  4RKK A;  2CMB A;  2QDC A;  4H34 A;  3H2X A;  1WRM A;  2I1Y A;  2QEP A;  4YAA A;  3QCK A;  2H02 A;  3QKP A;  1T49 A;  4PVG A;  4JMK A;  2GWO A;  5KAB A;  1OHC A;  3S3K A;  4GE6 A;  1OET A;  1U25 A;  4IKC A;  1I9S A;  3U96 A;  1EEO A;  2QCT A;  3O4S A;  4HRF A;  2AM2 A;  1XM2 A;  3BLU A;  4GFU A; 
#chains in the Genus database with same CATH homology
 1C88 A;  3V0G A;  4D3Q A;  1WCH A;  3RZ2 A;  4DGP A;  1ZCK A;  4GE5 A;  3RO1 A;  2BIJ A;  2I4E A;  1WAX A;  2B3O A;  4RH5 A;  4QAH A;  1EEN A;  3OLR A;  1D5R A;  2H4K A;  5KAC A;  1ZZW A;  3D1O A;  1T4J A;  5GTJ A;  4D3R A;  5BUG A;  1GFY A;  1X24 A;  2CNF A;  4RI5 A;  3D1H A;  2H04 A;  3MOZ A;  4GWF A;  5IBM A;  1Q6J A;  3EZZ A;  2BGD A;  1OEU A;  3RGO A;  2BV5 A;  3S3F A;  4NWG A;  1YTW A;  1L8G A;  1Q6N A;  3O5X A;  2NT7 A;  3ZMQ A;  5KA8 A;  2A8B A;  2VEX A;  2B4O A;  1OEV A;  1ONZ A;  2HNP A;  2I6M A;  3A5K A;  2Q05 A;  2IMG A;  2B4U A;  4RHG A;  3BRH A;  4I8N A;  4Z6B A;  2R0B A;  3D44 A;  2VEW A;  3EB1 A;  3D1Q A;  4GE2 A;  1JLN A;  4KYQ A;  2F6F A;  3S4E A;  4RH9 A;  1YTS A;  2WGP A;  2Q47 A;  2FJN A;  2PT0 A;  3EMU A;  2CM3 A;  1YWF A;  1V3A A;  1LYV A;  2QCJ A;  5KA4 A;  2RF6 A;  1KAV A;  2BZL A;  1YZ4 A;  3CWE A;  2NV5 A;  3N0A A;  4NND A;  4OHL A;  4Y2E A;  1PYN A;  5K23 A;  2QBP A;  1J4X A;  2I5X A;  4RI4 A;  1PTT A;  2I6I A;  4GRY A;  3D9C A;  2QDM A;  4D3P A;  5MMZ B;  2OUD A;  1XXV A;  1OEM X;  3F9B A;  2HCM A;  3AWE A;  2F6Y A;  3SR9 A;  3BLT A;  3QCC A;  1RPM A;  2JJD A;  3I80 A;  1G7G A;  2I4G A;  4ZRT A;  4BJO A;  1C86 A;  1BZJ A;  5HDE A;  2QBR A;  4JBC A;  4H1O A;  2YDU A;  2CMC A;  1G4U S;  2PBN A;  2J16 B;  2I6O A;  1SUG A;  2QDP A;  4OHH A;  1P15 A;  4GS0 A;  4QBE A;  1ZCL A;  4J51 A;  1G4W R;  1C85 A;  3I36 A;  1Q1M A;  1ONY A;  2NT2 A;  1XXP A;  2I4H A;  1C84 A;  4NWF A;  2F6V A;  2PSZ A;  1PH0 A;  4PYH A;  1JF7 A;  3ZM1 A;  5K9V A;  5IBS A;  3S3H A;  2ZN7 A;  2OZ5 A;  1XBO A;  4KYR A;  4RDD A;  3QCM A;  1PTU A;  4ZN5 A;  2CNG A;  1U24 A;  3RGQ A;  4MBB A;  4QUN A;  3V0J A;  5BZZ A;  2QBS A;  4ERC A;  1BZC A;  1LQF A;  1RXD A;  5KA1 A;  1YTN A;  2NTA A;  3SME A;  4WU2 A;  2B07 A;  3PS5 A;  2HC2 A;  4R30 A;  4R0T A;  1YN9 A;  3S3E A;  5KA2 A;  2ZMM A;  1G1G A;  2P4D A;  4OHI A;  1BZH A;  2QBQ A;  3EAX A;  1PTY A;  2AHS A;  1VHR A;  3EU0 A;  3CM3 A;  1AAX A;  2OOQ A;  1NWE A;  4TVV A;  3GXH A;  2I6P A;  1YPT A;  5KA3 A;  3D42 A;  3M4U A;  2CJZ A;  5EHR A;  4OHD A;  2H4V A;  1QZ0 A;  3AWF A;  5KA9 A;  4WTY A;  3MMJ A;  1C87 A;  4WOH A;  1ZC0 A;  2F6W A;  1R6H A;  3NME A;  1NZ7 A;  2FH7 A;  2MBC A;  3QCB A;  3AWG A;  2F46 A;  4S0G A;  1GWZ A;  1A5Y A;  2B49 A;  3F99 A;  1OHE A;  3F41 A;  3O4U A;  2CM7 A;  3O4T A;  1FQ1 A;  2NLK A;  3QCJ A;  2HNQ A;  3ZV2 A;  2CMA A;  1NNY A;  1Q6S A;  1T48 A;  3V0I A;  5KA0 A;  4QAP A;  3QCL A;  2HC1 A;  4YR8 B;  4GFV A;  1LAR A;  1Q6M A;  2I3R A;  4NYH A;  5K9W A;  3OMH A;  5KA7 A;  1PXH A;  2B4S A;  2OC3 A;  2J16 A;  2G59 A;  3GXG A;  4GRZ A;  3LJ8 A;  3V0F A;  1I57 A;  2CNE A;  5J8R A;  2PI7 A;  1G7F A;  2F6T A;  3QCN A;  3QCE A;  4NX8 A;  2I75 A;  2DXP A;  1Q6T A;  2HVL A;  5K22 A;  4ICZ A;  5KAA A;  5AWX A;  1NWL A;  5BX1 A;  2CM8 A;  1OEO X;  2H4G A;  2Y2F A;  2E0T A;  1OHD A;  2BGE A;  2HXP A;  1XRI A;  4ZI4 A;  3QCH A;  1Q6P A;  3ZM0 A;  2M3V A;  2CNH A;  2I3U A;  5LXQ B;  1PA1 A;  2VEV A;  2H03 A;  4JMJ A;  3QCF A;  2FJM A;  2PA5 A;  1FPZ A;  2ESB A;  4Y14 A;  1I9T A;  2SHP A;  1YGR A;  3B7O A;  4R0S A;  2Y96 A;  3O3L A;  1M3G A;  3ZM3 A;  2CNI A;  4WU3 A;  1YFO A;  3A5J A;  4AZ1 A;  2VEY A;  2GJT A;  4KI9 A;  2NZ6 A;  3BM8 A;  5K24 A;  5K25 A;  2F70 A;  4QUM A;  1C83 A;  1FPR A;  2P6X A;  3QKQ A;  2PQ5 A;  5M43 A;  1PTV A;  1KAK A;  4DGX A;  1NO6 A;  1MKP A;  4OHE A;  4HJP A;  3V0E A;  2A3K A;  2HY3 A;  3V0H A;  4BPC A;  3QCG A;  3V0D A;  1PA9 A;  2F71 A;  1NL9 A;  4HJQ A;  2B4P A;  3F81 A;  2F6Z A;  2I42 A;  2C7S A;  1L8K A;  2GP0 A;  2AZR A;  1U26 A;  2HB1 A;  3I7Z A;  4QBW A;  1G1H A;  5I6V A;  1ECV A;  4JNB A;  3S4O A;  1QXK A;  5KAD A;  2C46 A;  2CFV A;  5EHP A;  3F9A A;  2VEU A;  5BZX A;  2CM2 A;  2I6J A;  2J17 A;  4B04 A;  1OES A;  3QCD A;  3MOW A;  3ZM2 A;  1YGU A;  3ZMP A;  3QCI A;  2G6Z A;  1G1F A;  4RKK A;  2CMB A;  2QDC A;  4H34 A;  3H2X A;  1WRM A;  2I1Y A;  2QEP A;  4YAA A;  3QCK A;  2H02 A;  3QKP A;  1T49 A;  4PVG A;  4JMK A;  2GWO A;  5KAB A;  1OHC A;  3S3K A;  4GE6 A;  1OET A;  1U25 A;  4IKC A;  1I9S A;  3U96 A;  1EEO A;  2QCT A;  3O4S A;  4HRF A;  1XM2 A;  3BLU A;  4GFU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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