1NO6A

Potent, selective protein tyrosine phosphatase 1b inhibitor compound 5 using a linked-fragment strategy
Total Genus 97
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
97
sequence length
282
structure length
282
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Protein-tyrosine phosphatase, non-receptor type 1
total genus 97
structure length 282
sequence length 282
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2003-01-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 1no6A00
1MKPA 3ZM3A 1YTNA 3H2XA 2C46A 2C7SA 3MMJA 5IBSA 3D1QA 2WGPA 5M43A 3QCFA 2I4GA 4ICZA 2HC1A 3O4SA 4RKKA 1PH0A 2QCJA 3ZM1A 4IKCA 3CM3A 1ZZWA 4J51A 3ZM0A 1G7FA 3ZMPA 5KACA 4OHLA 1PTUA 3V0GA 2CNIA 4NNDA 1SUGA 2VEVA 4S0GA 4GRZA 1U24A 1FPRA 3EU0A 2CMBA 2J16A 2M3VA 3B7OA 1YGUA 1GFYA 1YTWA 3D1OA 2BGDA 1I9TA 4ZN5A 2CNGA 1T49A 1YN9A 2I6JA 4YAAA 3OLRA 2MBCA 2QBQA 2BV5A 3V0JA 2NLKA 2NTAA 4Y2EA 4GWFA 3QCGA 2F6YA 2F71A 4OHDA 3S4OA 5KA2A 1I9SA 2H4KA 2HY3A 1RXDA 3PS5A 3QCJA 1WCHA 4QUMA 3M4UA 1OHCA 4MBBA 4H34A 4D3RA 2P4DA 5HDEA 3I7ZA 2PSZA 1RPMA 2NT7A 1NO6A 4ERCA 1WAXA 3BLTA 4NYHA 3QCEA 3AWFA 5K25A 1U26A 4JMJA 2DXPA 5KA9A 3I36A 1NNYA 2CNFA 2RF6A 4QBEA 2ZMMA 4HRFA 3GXHA 1XBOA 2ESBA 1G7GA 2G59A 2Y2FA 3LJ8A 4JMKA 2BZLA 2NV5A 2I3UA 4GFVA 1PTYA 5KAAA 2QBPA 4Z6BA 4ZRTA 5K24A 2R0BA 1LQFA 3BLUA 4Y14A 2QBRA 1PA1A 1OHDA 4WU2A 2CM2A 4GRYA 4HJPA 1G1HA 1G1FA 1J4XA 1KAKA 4KYRA 2HNPA 3SMEA 5MMZB 1BZHA 2PQ5A 3QCDA 2I4HA 1YFOA 3EMUA 1T48A 4QAHA 4RH9A 2FJMA 2QDMA 3EB1A 2Y96A 1C85A 4JNBA 1XM2A 2CNEA 5KABA 1OETA 4QBWA 2SHPA 4WTYA 4JBCA 4PYHA 1OEVA 4R30A 2I5XA 2IMGA 2PBNA 1XXVA 2I75A 4OHHA 4KYQA 3QCBA 3F9BA 1FQ1A 4WU3A 2PT0A 1NWEA 3V0FA 4TVVA 5EHRA 2B4OA 1XRIA 3EZZA 2OOQA 1OESA 1T4JA 1ZCLA 2CM7A 1LYVA 4GFUA 4DGXA 4NX8A 1PTVA 3D9CA 3F9AA 5KA0A 1P15A 2B49A 1JLNA 4B04A 2B4PA 1YWFA 2QEPA 3V0DA 2BIJA 2Q47A 2B07A 1G4US 3QCNA 3SR9A 2NZ6A 3A5JA 3ZV2A 5LXQB 1NWLA 4D3QA 1Q6SA 4RDDA 1PYNA 5AWXA 2F70A 2FJNA 2VEYA 1L8GA 3F81A 3O3LA 3RGQA 3V0IA 2OZ5A 3QCIA 1G1GA 1OEUA 1ZC0A 2VEUA 5BZXA 1LARA 4PVGA 4GE5A 1ECVA 1C83A 1QZ0A 4KI9A 2J16B 4RH5A 3QCCA 3S3EA 3ZM2A 2JJDA 1WRMA 2CM3A 3BRHA 2E0TA 1ONYA 3QCHA 3F99A 3MOZA 1VHRA 1R6HA 2B3OA 4YR8B 1X24A 1C86A 2I4EA 2B4UA 2HNQA 5IBMA 4DGPA 2J17A 1PXHA 1L8KA 2F6FA 1EENA 3RZ2A 5I6VA 5KA7A 3MOWA 4NWGA 5K23A 3D44A 1Q6PA 2I42A 3F41A 2OC3A 3O5XA 3AWEA 3I80A 3QKQA 3RGOA 2AHSA 1V3AA 2H4GA 2H03A 2QCTA 2HCMA 2B4SA 1G4WR 2F6VA 2NT2A 3S3FA 3EAXA 2FH7A 2PA5A 3O4TA 1BZCA 1PTTA 2HXPA 3N0AA 1JF7A 1GWZA 2F6WA 3NMEA 3BM8A 2HC2A 1OHEA 2A8BA 3S3KA 3D42A 1Q6JA 4R0TA 1C87A 5K9WA 2F6TA 4R0SA 1FPZA 4H1OA 2OUDA 2CM8A 2CJZA 1OEOX 2H04A 1OEMX 2I1YA 4RHGA 3AWGA 2A3KA 3V0EA 3CWEA 2Q05A 5EHPA 2I6IA 1C84A 2HB1A 2H4VA 2BGEA 1U25A 4QAPA 2H02A 4WOHA 5K9VA 4QUNA 3S3HA 2VEWA 3O4UA 4NWFA 5KA1A 2G6ZA 1XXPA 1Q1MA 2F46A 1PA9A 1YZ4A 2PI7A 3S4EA 5KA4A 3QCKA 1YPTA 4BPCA 1YGRA 2QDPA 2CMCA 2F6ZA 4GE6A 1I57A 4AZ1A 4GE2A 5BUGA 2QBSA 1QXKA 4OHEA 3OMHA 4ZI4A 2CNHA 2P6XA 5KA8A 1AAXA 5KADA 1M3GA 2GWOA 1NZ7A 5KA3A 1Q6MA 4BJOA 1NL9A 5BX1A 4D3PA 2YDUA 1KAVA 2CFVA 4HJQA 2HVLA 2I6PA 1BZJA 2GP0A 1A5YA 3RO1A 3QCLA 3QKPA 2I6OA 1Q6NA 3A5KA 4I8NA 5GTJA 1D5RA 2VEXA 2QDCA 1YTSA 2AZRA 2I6MA 2ZN7A 4OHIA 1Q6TA 3U96A 5K22A 4RI4A 2GJTA 3ZMQA 1C88A 4RI5A 1ONZA 3D1HA 3QCMA 2CMAA 1EEOA 5BZZA 3V0HA 1ZCKA 5J8RA 3GXGA 2I3RA 4GS0A
chains in the Genus database with same CATH superfamily
1MKPA 3ZM3A 1YTNA 3H2XA 2C46A 2C7SA 3MMJA 5IBSA 3D1QA 2WGPA 5M43A 3QCFA 2I4GA 4ICZA 2GCBA 2HC1A 3O4SA 4RKKA 1PH0A 2UAGA 2QCJA 3ZM1A 4IKCA 3CM3A 1ZZWA 4J51A 3ZM0A 1G7FA 3ZMPA 5KACA 4OHLA 1PTUA 3V0GA 2CNIA 4NNDA 2VTEA 1SUGA 3QCZA 2VEVA 4S0GA 4GRZA 4C13A 1U24A 1FPRA 3EU0A 4BUBA 2CMBA 2J16A 2M3VA 3B7OA 1YGUA 1GFYA 1YTWA 3D1OA 2BGDA 1I9TA 4ZN5A 2CNGA 4QDIA 1T49A 1YN9A 2I6JA 4YAAA 3OLRA 2MBCA 2QBQA 2BV5A 3V0JA 2NLKA 2NTAA 4Y2EA 2GC6A 1O5ZA 4GWFA 3QCGA 2F6YA 2F71A 4OHDA 3S4OA 5KA2A 1I9SA 2H4KA 2HY3A 1RXDA 3PS5A 4ZIYA 3QCJA 1WCHA 4QUMA 3M4UA 1OHCA 4MBBA 4H34A 4HV4A 4D3RA 2P4DA 5HDEA 3I7ZA 2PSZA 1RPMA 2NT7A 1NO6A 4ERCA 1WAXA 1GQQA 3BLTA 4NYHA 3QCEA 3AWFA 5K25A 1U26A 4JMJA 2DXPA 5KA9A 3I36A 1NNYA 2CNFA 2RF6A 2Y68A 4QBEA 2ZMMA 4HRFA 3GXHA 1XBOA 2ESBA 1G7GA 2G59A 2JFHA 1EEHA 2JFFA 2Y2FA 3LJ8A 4JMKA 2BZLA 2VTDA 2NV5A 2I3UA 4GFVA 1PTYA 5KAAA 2QBPA 4Z6BA 3ZM5A 4ZRTA 5K24A 2R0BA 1LQFA 3NRSA 3BLUA 4Y14A 2QBRA 1PA1A 1OHDA 4WU2A 2CM2A 4GRYA 4HJPA 2Y67A 1G1HA 2JFGA 1G1FA 4UAGA 1J4XA 1KAKA 4KYRA 2HNPA 3SMEA 5MMZB 1BZHA 1JBVA 2AM1A 2PQ5A 3QCDA 2I4HA 1YFOA 3EMUA 1T48A 2XJAA 4QAHA 4C12A 4RH9A 2FJMA 2QDMA 3EB1A 2Y96A 1C85A 4JNBA 1XM2A 1P3DA 2CNEA 5KABA 1OETA 2Y66A 4QBWA 2SHPA 4WTYA 4JBCA 4PYHA 1OEVA 4R30A 2I5XA 2IMGA 2PBNA 1XXVA 2I75A 4OHHA 4KYQA 3QCBA 3F9BA 1FQ1A 4WU3A 1W7KA 2PT0A 1NWEA 3V0FA 4TVVA 5A5FA 5EHRA 4CVLA 2B4OA 1XRIA 3EZZA 2OOQA 1OESA 1T4JA 1ZCLA 4QF5A 2CM7A 1LYVA 4GFUA 4DGXA 4NX8A 1GQYA 1PTVA 3D9CA 3F9AA 5KA0A 1P15A 3MVNA 2B49A 1JLNA 4B04A 2B4PA 1YWFA 2QEPA 3V0DA 2BIJA 2Q47A 3PYZA 2B07A 1G4US 3QCNA 2UUPA 3SR9A 2NZ6A 3A5JA 3ZV2A 5LXQB 1NWLA 4D3QA 1Q6SA 4RDDA 1PYNA 5AWXA 2F70A 2FJNA 2VEYA 4BUCA 1L8GA 2GC5A 3F81A 3O3LA 3RGQA 1FGSA 3V0IA 2OZ5A 2Y1OA 3LK7A 3QCIA 1G1GA 1OEUA 1ZC0A 2VEUA 5BZXA 1LARA 4PVGA 4GE5A 1ECVA 1C83A 1QZ0A 4KI9A 2J16B 4RH5A 3QCCA 3S3EA 3ZM2A 2JJDA 1WRMA 2CM3A 1JBWA 2UUOA 3BRHA 2E0TA 1ONYA 3QCHA 3F99A 3MOZA 1VHRA 1R6HA 2B3OA 4YR8B 1X24A 1C86A 2I4EA 2B4UA 2HNQA 5IBMA 4DGPA 2J17A 1PXHA 1L8KA 2F6FA 1EENA 3RZ2A 5I6VA 5KA7A 3MOWA 4NWGA 5K23A 3D44A 1Q6PA 4CVKA 2I42A 3F41A 2OC3A 3O5XA 3AWEA 3I80A 3QKQA 3RGOA 3ZL8A 2AHSA 2GCAA 1V3AA 2XPCA 2H4GA 2H03A 1W78A 2QCTA 2HCMA 2B4SA 1G4WR 2F6VA 2NT2A 3S3FA 3EAXA 2FH7A 2PA5A 3O4TA 1BZCA 1PTTA 2HXPA 3N0AA 1JF7A 1GWZA 2F6WA 3NMEA 3N2AA 3BM8A 2HC2A 1OHEA 2A8BA 3S3KA 3D42A 1Q6JA 4R0TA 1C87A 5K9WA 1GG4A 2F6TA 4R0SA 1FPZA 4H1OA 1E0DA 2OUDA 2CM8A 3ZM6A 2CJZA 5A5EA 1OEOX 2H04A 1OEMX 2I1YA 4RHGA 3AWGA 2A3KA 3V0EA 3CWEA 2Q05A 5EHPA 2I6IA 1C84A 2HB1A 2H4VA 2BGEA 1U25A 4QAPA 2H02A 4WOHA 5K9VA 4QUNA 2WTZA 3S3HA 2VEWA 3O4UA 4NWFA 5KA1A 2G6ZA 1E8CA 1XXPA 1Q1MA 2VOSA 2F46A 1PA9A 1YZ4A 2PI7A 3S4EA 5KA4A 3QCKA 1YPTA 3UAGA 4BPCA 4CVMA 1YGRA 2QDPA 2CMCA 2F6ZA 4GE6A 1I57A 4AZ1A 2F00A 4GE2A 5BUGA 2QBSA 1QXKA 4OHEA 3OMHA 4ZI4A 2CNHA 2P6XA 5KA8A 1AAXA 5KADA 1M3GA 2GWOA 2X5OA 1NZ7A 5KA3A 1Q6MA 4BJOA 1NL9A 5BX1A 4D3PA 2YDUA 1KAVA 2CFVA 4HJQA 1J6UA 2HVLA 2I6PA 1BZJA 2GP0A 1A5YA 3RO1A 1P31A 3QCLA 3QKPA 2I6OA 1Q6NA 3A5KA 4I8NA 5GTJA 1D5RA 2VEXA 2AM2A 3HN7A 2QDCA 1UAGA 1YTSA 2AZRA 2I6MA 2ZN7A 4OHIA 1Q6TA 3U96A 5K22A 4RI4A 2GJTA 3ZMQA 1C88A 4RI5A 1ONZA 3D1HA 3QCMA 2VORA 2CMAA 1EEOA 5BZZA 3V0HA 1ZCKA 2WJPA 5J8RA 3GXGA 2I3RA 4GS0A
chains in the Genus database with same CATH topology
1MKPA 3ZM3A 1YTNA 3H2XA 2C46A 2C7SA 3MMJA 5IBSA 3D1QA 2WGPA 5M43A 3QCFA 2I4GA 4ICZA 2HC1A 3O4SA 4RKKA 1PH0A 2QCJA 3ZM1A 4IKCA 3CM3A 1ZZWA 4J51A 3ZM0A 1G7FA 3ZMPA 5KACA 4OHLA 1PTUA 3V0GA 2CNIA 4NNDA 1SUGA 2VEVA 4S0GA 4GRZA 1U24A 1FPRA 3EU0A 2CMBA 2J16A 2M3VA 3B7OA 1YGUA 1GFYA 1YTWA 3D1OA 2BGDA 1I9TA 4ZN5A 2CNGA 1T49A 1YN9A 2I6JA 4YAAA 3OLRA 2MBCA 2QBQA 2BV5A 3V0JA 2NLKA 2NTAA 4Y2EA 4GWFA 3QCGA 2F6YA 2F71A 4OHDA 3S4OA 5KA2A 1I9SA 2H4KA 2HY3A 1RXDA 3PS5A 3QCJA 1WCHA 4QUMA 3M4UA 1OHCA 4MBBA 4H34A 4D3RA 2P4DA 5HDEA 3I7ZA 2PSZA 1RPMA 2NT7A 1NO6A 4ERCA 1WAXA 3BLTA 4NYHA 3QCEA 3AWFA 5K25A 1U26A 4JMJA 2DXPA 5KA9A 3I36A 1NNYA 2CNFA 2RF6A 4QBEA 2ZMMA 4HRFA 3GXHA 1XBOA 2ESBA 1G7GA 2G59A 2Y2FA 3LJ8A 4JMKA 2BZLA 2NV5A 2I3UA 4GFVA 1PTYA 5KAAA 2QBPA 4Z6BA 4ZRTA 5K24A 2R0BA 1LQFA 3BLUA 4Y14A 2QBRA 1PA1A 1OHDA 4WU2A 2CM2A 4GRYA 4HJPA 1G1HA 1G1FA 1J4XA 1KAKA 4KYRA 2HNPA 3SMEA 5MMZB 1BZHA 2PQ5A 3QCDA 2I4HA 1YFOA 3EMUA 1T48A 4QAHA 4RH9A 2FJMA 2QDMA 3EB1A 2Y96A 1C85A 4JNBA 1XM2A 2CNEA 5KABA 1OETA 4QBWA 2SHPA 4WTYA 4JBCA 4PYHA 1OEVA 4R30A 2I5XA 2IMGA 2PBNA 1XXVA 2I75A 4OHHA 4KYQA 3QCBA 3F9BA 1FQ1A 4WU3A 2PT0A 1NWEA 3V0FA 4TVVA 5EHRA 2B4OA 1XRIA 3EZZA 2OOQA 1OESA 1T4JA 1ZCLA 2CM7A 1LYVA 4GFUA 4DGXA 4NX8A 1PTVA 3D9CA 3F9AA 5KA0A 1P15A 2B49A 1JLNA 4B04A 2B4PA 1YWFA 2QEPA 3V0DA 2BIJA 2Q47A 2B07A 1G4US 3QCNA 3SR9A 2NZ6A 3A5JA 3ZV2A 5LXQB 1NWLA 4D3QA 1Q6SA 4RDDA 1PYNA 5AWXA 2F70A 2FJNA 2VEYA 1L8GA 3F81A 3O3LA 3RGQA 3V0IA 2OZ5A 3QCIA 1G1GA 1OEUA 1ZC0A 2VEUA 5BZXA 1LARA 4PVGA 4GE5A 1ECVA 1C83A 1QZ0A 4KI9A 2J16B 4RH5A 3QCCA 3S3EA 3ZM2A 2JJDA 1WRMA 2CM3A 3BRHA 2E0TA 1ONYA 3QCHA 3F99A 3MOZA 1VHRA 1R6HA 2B3OA 4YR8B 1X24A 1C86A 2I4EA 2B4UA 2HNQA 5IBMA 4DGPA 2J17A 1PXHA 1L8KA 2F6FA 1EENA 3RZ2A 5I6VA 5KA7A 3MOWA 4NWGA 5K23A 3D44A 1Q6PA 2I42A 3F41A 2OC3A 3O5XA 3AWEA 3I80A 3QKQA 3RGOA 2AHSA 1V3AA 2H4GA 2H03A 2QCTA 2HCMA 2B4SA 1G4WR 2F6VA 2NT2A 3S3FA 3EAXA 2FH7A 2PA5A 3O4TA 1BZCA 1PTTA 2HXPA 3N0AA 1JF7A 1GWZA 2F6WA 3NMEA 3BM8A 2HC2A 1OHEA 2A8BA 3S3KA 3D42A 1Q6JA 4R0TA 1C87A 5K9WA 2F6TA 4R0SA 1FPZA 4H1OA 2OUDA 2CM8A 2CJZA 1OEOX 2H04A 1OEMX 2I1YA 4RHGA 3AWGA 2A3KA 3V0EA 3CWEA 2Q05A 5EHPA 2I6IA 1C84A 2HB1A 2H4VA 2BGEA 1U25A 4QAPA 2H02A 4WOHA 5K9VA 4QUNA 3S3HA 2VEWA 3O4UA 4NWFA 5KA1A 2G6ZA 1XXPA 1Q1MA 2F46A 1PA9A 1YZ4A 2PI7A 3S4EA 5KA4A 3QCKA 1YPTA 4BPCA 1YGRA 2QDPA 2CMCA 2F6ZA 4GE6A 1I57A 4AZ1A 4GE2A 5BUGA 2QBSA 1QXKA 4OHEA 3OMHA 4ZI4A 2CNHA 2P6XA 5KA8A 1AAXA 5KADA 1M3GA 2GWOA 1NZ7A 5KA3A 1Q6MA 4BJOA 1NL9A 5BX1A 4D3PA 2YDUA 1KAVA 2CFVA 4HJQA 2HVLA 2I6PA 1BZJA 2GP0A 1A5YA 3RO1A 3QCLA 3QKPA 2I6OA 1Q6NA 3A5KA 4I8NA 5GTJA 1D5RA 2VEXA 2QDCA 1YTSA 2AZRA 2I6MA 2ZN7A 4OHIA 1Q6TA 3U96A 5K22A 4RI4A 2GJTA 3ZMQA 1C88A 4RI5A 1ONZA 3D1HA 3QCMA 2CMAA 1EEOA 5BZZA 3V0HA 1ZCKA 5J8RA 3GXGA 2I3RA 4GS0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MKP A;  3ZM3 A;  1YTN A;  3H2X A;  2C46 A;  2C7S A;  3MMJ A;  5IBS A;  3D1Q A;  2WGP A;  5M43 A;  3QCF A;  2I4G A;  4ICZ A;  2HC1 A;  3O4S A;  4RKK A;  1PH0 A;  2QCJ A;  3ZM1 A;  4IKC A;  3CM3 A;  1ZZW A;  4J51 A;  3ZM0 A;  1G7F A;  3ZMP A;  5KAC A;  4OHL A;  1PTU A;  3V0G A;  2CNI A;  4NND A;  1SUG A;  2VEV A;  4S0G A;  4GRZ A;  1U24 A;  1FPR A;  3EU0 A;  2CMB A;  2J16 A;  2M3V A;  3B7O A;  1YGU A;  1GFY A;  1YTW A;  3D1O A;  2BGD A;  1I9T A;  4ZN5 A;  2CNG A;  1T49 A;  1YN9 A;  2I6J A;  4YAA A;  3OLR A;  2MBC A;  2QBQ A;  2BV5 A;  3V0J A;  2NLK A;  2NTA A;  4Y2E A;  4GWF A;  3QCG A;  2F6Y A;  2F71 A;  4OHD A;  3S4O A;  5KA2 A;  1I9S A;  2H4K A;  2HY3 A;  1RXD A;  3PS5 A;  3QCJ A;  1WCH A;  4QUM A;  3M4U A;  1OHC A;  4MBB A;  4H34 A;  4D3R A;  2P4D A;  5HDE A;  3I7Z A;  2PSZ A;  1RPM A;  2NT7 A;  1NO6 A;  4ERC A;  1WAX A;  3BLT A;  4NYH A;  3QCE A;  3AWF A;  5K25 A;  1U26 A;  4JMJ A;  2DXP A;  5KA9 A;  3I36 A;  1NNY A;  2CNF A;  2RF6 A;  4QBE A;  2ZMM A;  4HRF A;  3GXH A;  1XBO A;  2ESB A;  1G7G A;  2G59 A;  2Y2F A;  3LJ8 A;  4JMK A;  2BZL A;  2NV5 A;  2I3U A;  4GFV A;  1PTY A;  5KAA A;  2QBP A;  4Z6B A;  4ZRT A;  5K24 A;  2R0B A;  1LQF A;  3BLU A;  4Y14 A;  2QBR A;  1PA1 A;  1OHD A;  4WU2 A;  2CM2 A;  4GRY A;  4HJP A;  1G1H A;  1G1F A;  1J4X A;  1KAK A;  4KYR A;  2HNP A;  3SME A;  5MMZ B;  1BZH A;  2PQ5 A;  3QCD A;  2I4H A;  1YFO A;  3EMU A;  1T48 A;  4QAH A;  4RH9 A;  2FJM A;  2QDM A;  3EB1 A;  2Y96 A;  1C85 A;  4JNB A;  1XM2 A;  2CNE A;  5KAB A;  1OET A;  4QBW A;  2SHP A;  4WTY A;  4JBC A;  4PYH A;  1OEV A;  4R30 A;  2I5X A;  2IMG A;  2PBN A;  1XXV A;  2I75 A;  4OHH A;  4KYQ A;  3QCB A;  3F9B A;  1FQ1 A;  4WU3 A;  2PT0 A;  1NWE A;  3V0F A;  4TVV A;  5EHR A;  2B4O A;  1XRI A;  3EZZ A;  2OOQ A;  1OES A;  1T4J A;  1ZCL A;  2CM7 A;  1LYV A;  4GFU A;  4DGX A;  4NX8 A;  1PTV A;  3D9C A;  3F9A A;  5KA0 A;  1P15 A;  2B49 A;  1JLN A;  4B04 A;  2B4P A;  1YWF A;  2QEP A;  3V0D A;  2BIJ A;  2Q47 A;  2B07 A;  1G4U S;  3QCN A;  3SR9 A;  2NZ6 A;  3A5J A;  3ZV2 A;  5LXQ B;  1NWL A;  4D3Q A;  1Q6S A;  4RDD A;  1PYN A;  5AWX A;  2F70 A;  2FJN A;  2VEY A;  1L8G A;  3F81 A;  3O3L A;  3RGQ A;  3V0I A;  2OZ5 A;  3QCI A;  1G1G A;  1OEU A;  1ZC0 A;  2VEU A;  5BZX A;  1LAR A;  4PVG A;  4GE5 A;  1ECV A;  1C83 A;  1QZ0 A;  4KI9 A;  2J16 B;  4RH5 A;  3QCC A;  3S3E A;  3ZM2 A;  2JJD A;  1WRM A;  2CM3 A;  3BRH A;  2E0T A;  1ONY A;  3QCH A;  3F99 A;  3MOZ A;  1VHR A;  1R6H A;  2B3O A;  4YR8 B;  1X24 A;  1C86 A;  2I4E A;  2B4U A;  2HNQ A;  5IBM A;  4DGP A;  2J17 A;  1PXH A;  1L8K A;  2F6F A;  1EEN A;  3RZ2 A;  5I6V A;  5KA7 A;  3MOW A;  4NWG A;  5K23 A;  3D44 A;  1Q6P A;  2I42 A;  3F41 A;  2OC3 A;  3O5X A;  3AWE A;  3I80 A;  3QKQ A;  3RGO A;  2AHS A;  1V3A A;  2H4G A;  2H03 A;  2QCT A;  2HCM A;  2B4S A;  1G4W R;  2F6V A;  2NT2 A;  3S3F A;  3EAX A;  2FH7 A;  2PA5 A;  3O4T A;  1BZC A;  1PTT A;  2HXP A;  3N0A A;  1JF7 A;  1GWZ A;  2F6W A;  3NME A;  3BM8 A;  2HC2 A;  1OHE A;  2A8B A;  3S3K A;  3D42 A;  1Q6J A;  4R0T A;  1C87 A;  5K9W A;  2F6T A;  4R0S A;  1FPZ A;  4H1O A;  2OUD A;  2CM8 A;  2CJZ A;  1OEO X;  2H04 A;  1OEM X;  2I1Y A;  4RHG A;  3AWG A;  2A3K A;  3V0E A;  3CWE A;  2Q05 A;  5EHP A;  2I6I A;  1C84 A;  2HB1 A;  2H4V A;  2BGE A;  1U25 A;  4QAP A;  2H02 A;  4WOH A;  5K9V A;  4QUN A;  3S3H A;  2VEW A;  3O4U A;  4NWF A;  5KA1 A;  2G6Z A;  1XXP A;  1Q1M A;  2F46 A;  1PA9 A;  1YZ4 A;  2PI7 A;  3S4E A;  5KA4 A;  3QCK A;  1YPT A;  4BPC A;  1YGR A;  2QDP A;  2CMC A;  2F6Z A;  4GE6 A;  1I57 A;  4AZ1 A;  4GE2 A;  5BUG A;  2QBS A;  1QXK A;  4OHE A;  3OMH A;  4ZI4 A;  2CNH A;  2P6X A;  5KA8 A;  1AAX A;  5KAD A;  1M3G A;  2GWO A;  1NZ7 A;  5KA3 A;  1Q6M A;  4BJO A;  1NL9 A;  5BX1 A;  4D3P A;  2YDU A;  1KAV A;  2CFV A;  4HJQ A;  2HVL A;  2I6P A;  1BZJ A;  2GP0 A;  1A5Y A;  3RO1 A;  3QCL A;  3QKP A;  2I6O A;  1Q6N A;  3A5K A;  4I8N A;  5GTJ A;  1D5R A;  2VEX A;  2QDC A;  1YTS A;  2AZR A;  2I6M A;  2ZN7 A;  4OHI A;  1Q6T A;  3U96 A;  5K22 A;  4RI4 A;  2GJT A;  3ZMQ A;  1C88 A;  4RI5 A;  1ONZ A;  3D1H A;  3QCM A;  2CMA A;  1EEO A;  5BZZ A;  3V0H A;  1ZCK A;  5J8R A;  3GXG A;  2I3R A;  4GS0 A; 
#chains in the Genus database with same CATH topology
 1MKP A;  3ZM3 A;  1YTN A;  3H2X A;  2C46 A;  2C7S A;  3MMJ A;  5IBS A;  3D1Q A;  2WGP A;  5M43 A;  3QCF A;  2I4G A;  4ICZ A;  2GCB A;  2HC1 A;  3O4S A;  4RKK A;  1PH0 A;  2UAG A;  2QCJ A;  3ZM1 A;  4IKC A;  3CM3 A;  1ZZW A;  4J51 A;  3ZM0 A;  1G7F A;  3ZMP A;  5KAC A;  4OHL A;  1PTU A;  3V0G A;  2CNI A;  4NND A;  2VTE A;  1SUG A;  3QCZ A;  2VEV A;  4S0G A;  4GRZ A;  4C13 A;  1U24 A;  1FPR A;  3EU0 A;  4BUB A;  2CMB A;  2J16 A;  2M3V A;  3B7O A;  1YGU A;  1GFY A;  1YTW A;  3D1O A;  2BGD A;  1I9T A;  4ZN5 A;  2CNG A;  4QDI A;  1T49 A;  1YN9 A;  2I6J A;  4YAA A;  3OLR A;  2MBC A;  2QBQ A;  2BV5 A;  3V0J A;  2NLK A;  2NTA A;  4Y2E A;  2GC6 A;  1O5Z A;  4GWF A;  3QCG A;  2F6Y A;  2F71 A;  4OHD A;  3S4O A;  5KA2 A;  1I9S A;  2H4K A;  2HY3 A;  1RXD A;  3PS5 A;  4ZIY A;  3QCJ A;  1WCH A;  4QUM A;  3M4U A;  1OHC A;  4MBB A;  4H34 A;  4HV4 A;  4D3R A;  2P4D A;  5HDE A;  3I7Z A;  2PSZ A;  1RPM A;  2NT7 A;  1NO6 A;  4ERC A;  1WAX A;  1GQQ A;  3BLT A;  4NYH A;  3QCE A;  3AWF A;  5K25 A;  1U26 A;  4JMJ A;  2DXP A;  5KA9 A;  3I36 A;  1NNY A;  2CNF A;  2RF6 A;  2Y68 A;  4QBE A;  2ZMM A;  4HRF A;  3GXH A;  1XBO A;  2ESB A;  1G7G A;  2G59 A;  2JFH A;  1EEH A;  2JFF A;  2Y2F A;  3LJ8 A;  4JMK A;  2BZL A;  2VTD A;  2NV5 A;  2I3U A;  4GFV A;  1PTY A;  5KAA A;  2QBP A;  4Z6B A;  3ZM5 A;  4ZRT A;  5K24 A;  2R0B A;  1LQF A;  3NRS A;  3BLU A;  4Y14 A;  2QBR A;  1PA1 A;  1OHD A;  4WU2 A;  2CM2 A;  4GRY A;  4HJP A;  2Y67 A;  1G1H A;  2JFG A;  1G1F A;  4UAG A;  1J4X A;  1KAK A;  4KYR A;  2HNP A;  3SME A;  5MMZ B;  1BZH A;  1JBV A;  2AM1 A;  2PQ5 A;  3QCD A;  2I4H A;  1YFO A;  3EMU A;  1T48 A;  2XJA A;  4QAH A;  4C12 A;  4RH9 A;  2FJM A;  2QDM A;  3EB1 A;  2Y96 A;  1C85 A;  4JNB A;  1XM2 A;  1P3D A;  2CNE A;  5KAB A;  1OET A;  2Y66 A;  4QBW A;  2SHP A;  4WTY A;  4JBC A;  4PYH A;  1OEV A;  4R30 A;  2I5X A;  2IMG A;  2PBN A;  1XXV A;  2I75 A;  4OHH A;  4KYQ A;  3QCB A;  3F9B A;  1FQ1 A;  4WU3 A;  1W7K A;  2PT0 A;  1NWE A;  3V0F A;  4TVV A;  5A5F A;  5EHR A;  4CVL A;  2B4O A;  1XRI A;  3EZZ A;  2OOQ A;  1OES A;  1T4J A;  1ZCL A;  4QF5 A;  2CM7 A;  1LYV A;  4GFU A;  4DGX A;  4NX8 A;  1GQY A;  1PTV A;  3D9C A;  3F9A A;  5KA0 A;  1P15 A;  3MVN A;  2B49 A;  1JLN A;  4B04 A;  2B4P A;  1YWF A;  2QEP A;  3V0D A;  2BIJ A;  2Q47 A;  3PYZ A;  2B07 A;  1G4U S;  3QCN A;  2UUP A;  3SR9 A;  2NZ6 A;  3A5J A;  3ZV2 A;  5LXQ B;  1NWL A;  4D3Q A;  1Q6S A;  4RDD A;  1PYN A;  5AWX A;  2F70 A;  2FJN A;  2VEY A;  4BUC A;  1L8G A;  2GC5 A;  3F81 A;  3O3L A;  3RGQ A;  1FGS A;  3V0I A;  2OZ5 A;  2Y1O A;  3LK7 A;  3QCI A;  1G1G A;  1OEU A;  1ZC0 A;  2VEU A;  5BZX A;  1LAR A;  4PVG A;  4GE5 A;  1ECV A;  1C83 A;  1QZ0 A;  4KI9 A;  2J16 B;  4RH5 A;  3QCC A;  3S3E A;  3ZM2 A;  2JJD A;  1WRM A;  2CM3 A;  1JBW A;  2UUO A;  3BRH A;  2E0T A;  1ONY A;  3QCH A;  3F99 A;  3MOZ A;  1VHR A;  1R6H A;  2B3O A;  4YR8 B;  1X24 A;  1C86 A;  2I4E A;  2B4U A;  2HNQ A;  5IBM A;  4DGP A;  2J17 A;  1PXH A;  1L8K A;  2F6F A;  1EEN A;  3RZ2 A;  5I6V A;  5KA7 A;  3MOW A;  4NWG A;  5K23 A;  3D44 A;  1Q6P A;  4CVK A;  2I42 A;  3F41 A;  2OC3 A;  3O5X A;  3AWE A;  3I80 A;  3QKQ A;  3RGO A;  3ZL8 A;  2AHS A;  2GCA A;  1V3A A;  2XPC A;  2H4G A;  2H03 A;  1W78 A;  2QCT A;  2HCM A;  2B4S A;  1G4W R;  2F6V A;  2NT2 A;  3S3F A;  3EAX A;  2FH7 A;  2PA5 A;  3O4T A;  1BZC A;  1PTT A;  2HXP A;  3N0A A;  1JF7 A;  1GWZ A;  2F6W A;  3NME A;  3N2A A;  3BM8 A;  2HC2 A;  1OHE A;  2A8B A;  3S3K A;  3D42 A;  1Q6J A;  4R0T A;  1C87 A;  5K9W A;  1GG4 A;  2F6T A;  4R0S A;  1FPZ A;  4H1O A;  1E0D A;  2OUD A;  2CM8 A;  3ZM6 A;  2CJZ A;  5A5E A;  1OEO X;  2H04 A;  1OEM X;  2I1Y A;  4RHG A;  3AWG A;  2A3K A;  3V0E A;  3CWE A;  2Q05 A;  5EHP A;  2I6I A;  1C84 A;  2HB1 A;  2H4V A;  2BGE A;  1U25 A;  4QAP A;  2H02 A;  4WOH A;  5K9V A;  4QUN A;  2WTZ A;  3S3H A;  2VEW A;  3O4U A;  4NWF A;  5KA1 A;  2G6Z A;  1E8C A;  1XXP A;  1Q1M A;  2VOS A;  2F46 A;  1PA9 A;  1YZ4 A;  2PI7 A;  3S4E A;  5KA4 A;  3QCK A;  1YPT A;  3UAG A;  4BPC A;  4CVM A;  1YGR A;  2QDP A;  2CMC A;  2F6Z A;  4GE6 A;  1I57 A;  4AZ1 A;  2F00 A;  4GE2 A;  5BUG A;  2QBS A;  1QXK A;  4OHE A;  3OMH A;  4ZI4 A;  2CNH A;  2P6X A;  5KA8 A;  1AAX A;  5KAD A;  1M3G A;  2GWO A;  2X5O A;  1NZ7 A;  5KA3 A;  1Q6M A;  4BJO A;  1NL9 A;  5BX1 A;  4D3P A;  2YDU A;  1KAV A;  2CFV A;  4HJQ A;  1J6U A;  2HVL A;  2I6P A;  1BZJ A;  2GP0 A;  1A5Y A;  3RO1 A;  1P31 A;  3QCL A;  3QKP A;  2I6O A;  1Q6N A;  3A5K A;  4I8N A;  5GTJ A;  1D5R A;  2VEX A;  2AM2 A;  3HN7 A;  2QDC A;  1UAG A;  1YTS A;  2AZR A;  2I6M A;  2ZN7 A;  4OHI A;  1Q6T A;  3U96 A;  5K22 A;  4RI4 A;  2GJT A;  3ZMQ A;  1C88 A;  4RI5 A;  1ONZ A;  3D1H A;  3QCM A;  2VOR A;  2CMA A;  1EEO A;  5BZZ A;  3V0H A;  1ZCK A;  2WJP A;  5J8R A;  3GXG A;  2I3R A;  4GS0 A; 
#chains in the Genus database with same CATH homology
 1MKP A;  3ZM3 A;  1YTN A;  3H2X A;  2C46 A;  2C7S A;  3MMJ A;  5IBS A;  3D1Q A;  2WGP A;  5M43 A;  3QCF A;  2I4G A;  4ICZ A;  2HC1 A;  3O4S A;  4RKK A;  1PH0 A;  2QCJ A;  3ZM1 A;  4IKC A;  3CM3 A;  1ZZW A;  4J51 A;  3ZM0 A;  1G7F A;  3ZMP A;  5KAC A;  4OHL A;  1PTU A;  3V0G A;  2CNI A;  4NND A;  1SUG A;  2VEV A;  4S0G A;  4GRZ A;  1U24 A;  1FPR A;  3EU0 A;  2CMB A;  2J16 A;  2M3V A;  3B7O A;  1YGU A;  1GFY A;  1YTW A;  3D1O A;  2BGD A;  1I9T A;  4ZN5 A;  2CNG A;  1T49 A;  1YN9 A;  2I6J A;  4YAA A;  3OLR A;  2MBC A;  2QBQ A;  2BV5 A;  3V0J A;  2NLK A;  2NTA A;  4Y2E A;  4GWF A;  3QCG A;  2F6Y A;  2F71 A;  4OHD A;  3S4O A;  5KA2 A;  1I9S A;  2H4K A;  2HY3 A;  1RXD A;  3PS5 A;  3QCJ A;  1WCH A;  4QUM A;  3M4U A;  1OHC A;  4MBB A;  4H34 A;  4D3R A;  2P4D A;  5HDE A;  3I7Z A;  2PSZ A;  1RPM A;  2NT7 A;  1NO6 A;  4ERC A;  1WAX A;  3BLT A;  4NYH A;  3QCE A;  3AWF A;  5K25 A;  1U26 A;  4JMJ A;  2DXP A;  5KA9 A;  3I36 A;  1NNY A;  2CNF A;  2RF6 A;  4QBE A;  2ZMM A;  4HRF A;  3GXH A;  1XBO A;  2ESB A;  1G7G A;  2G59 A;  2Y2F A;  3LJ8 A;  4JMK A;  2BZL A;  2NV5 A;  2I3U A;  4GFV A;  1PTY A;  5KAA A;  2QBP A;  4Z6B A;  4ZRT A;  5K24 A;  2R0B A;  1LQF A;  3BLU A;  4Y14 A;  2QBR A;  1PA1 A;  1OHD A;  4WU2 A;  2CM2 A;  4GRY A;  4HJP A;  1G1H A;  1G1F A;  1J4X A;  1KAK A;  4KYR A;  2HNP A;  3SME A;  5MMZ B;  1BZH A;  2PQ5 A;  3QCD A;  2I4H A;  1YFO A;  3EMU A;  1T48 A;  4QAH A;  4RH9 A;  2FJM A;  2QDM A;  3EB1 A;  2Y96 A;  1C85 A;  4JNB A;  1XM2 A;  2CNE A;  5KAB A;  1OET A;  4QBW A;  2SHP A;  4WTY A;  4JBC A;  4PYH A;  1OEV A;  4R30 A;  2I5X A;  2IMG A;  2PBN A;  1XXV A;  2I75 A;  4OHH A;  4KYQ A;  3QCB A;  3F9B A;  1FQ1 A;  4WU3 A;  2PT0 A;  1NWE A;  3V0F A;  4TVV A;  5EHR A;  2B4O A;  1XRI A;  3EZZ A;  2OOQ A;  1OES A;  1T4J A;  1ZCL A;  2CM7 A;  1LYV A;  4GFU A;  4DGX A;  4NX8 A;  1PTV A;  3D9C A;  3F9A A;  5KA0 A;  1P15 A;  2B49 A;  1JLN A;  4B04 A;  2B4P A;  1YWF A;  2QEP A;  3V0D A;  2BIJ A;  2Q47 A;  2B07 A;  1G4U S;  3QCN A;  3SR9 A;  2NZ6 A;  3A5J A;  3ZV2 A;  5LXQ B;  1NWL A;  4D3Q A;  1Q6S A;  4RDD A;  1PYN A;  5AWX A;  2F70 A;  2FJN A;  2VEY A;  1L8G A;  3F81 A;  3O3L A;  3RGQ A;  3V0I A;  2OZ5 A;  3QCI A;  1G1G A;  1OEU A;  1ZC0 A;  2VEU A;  5BZX A;  1LAR A;  4PVG A;  4GE5 A;  1ECV A;  1C83 A;  1QZ0 A;  4KI9 A;  2J16 B;  4RH5 A;  3QCC A;  3S3E A;  3ZM2 A;  2JJD A;  1WRM A;  2CM3 A;  3BRH A;  2E0T A;  1ONY A;  3QCH A;  3F99 A;  3MOZ A;  1VHR A;  1R6H A;  2B3O A;  4YR8 B;  1X24 A;  1C86 A;  2I4E A;  2B4U A;  2HNQ A;  5IBM A;  4DGP A;  2J17 A;  1PXH A;  1L8K A;  2F6F A;  1EEN A;  3RZ2 A;  5I6V A;  5KA7 A;  3MOW A;  4NWG A;  5K23 A;  3D44 A;  1Q6P A;  2I42 A;  3F41 A;  2OC3 A;  3O5X A;  3AWE A;  3I80 A;  3QKQ A;  3RGO A;  2AHS A;  1V3A A;  2H4G A;  2H03 A;  2QCT A;  2HCM A;  2B4S A;  1G4W R;  2F6V A;  2NT2 A;  3S3F A;  3EAX A;  2FH7 A;  2PA5 A;  3O4T A;  1BZC A;  1PTT A;  2HXP A;  3N0A A;  1JF7 A;  1GWZ A;  2F6W A;  3NME A;  3BM8 A;  2HC2 A;  1OHE A;  2A8B A;  3S3K A;  3D42 A;  1Q6J A;  4R0T A;  1C87 A;  5K9W A;  2F6T A;  4R0S A;  1FPZ A;  4H1O A;  2OUD A;  2CM8 A;  2CJZ A;  1OEO X;  2H04 A;  1OEM X;  2I1Y A;  4RHG A;  3AWG A;  2A3K A;  3V0E A;  3CWE A;  2Q05 A;  5EHP A;  2I6I A;  1C84 A;  2HB1 A;  2H4V A;  2BGE A;  1U25 A;  4QAP A;  2H02 A;  4WOH A;  5K9V A;  4QUN A;  3S3H A;  2VEW A;  3O4U A;  4NWF A;  5KA1 A;  2G6Z A;  1XXP A;  1Q1M A;  2F46 A;  1PA9 A;  1YZ4 A;  2PI7 A;  3S4E A;  5KA4 A;  3QCK A;  1YPT A;  4BPC A;  1YGR A;  2QDP A;  2CMC A;  2F6Z A;  4GE6 A;  1I57 A;  4AZ1 A;  4GE2 A;  5BUG A;  2QBS A;  1QXK A;  4OHE A;  3OMH A;  4ZI4 A;  2CNH A;  2P6X A;  5KA8 A;  1AAX A;  5KAD A;  1M3G A;  2GWO A;  1NZ7 A;  5KA3 A;  1Q6M A;  4BJO A;  1NL9 A;  5BX1 A;  4D3P A;  2YDU A;  1KAV A;  2CFV A;  4HJQ A;  2HVL A;  2I6P A;  1BZJ A;  2GP0 A;  1A5Y A;  3RO1 A;  3QCL A;  3QKP A;  2I6O A;  1Q6N A;  3A5K A;  4I8N A;  5GTJ A;  1D5R A;  2VEX A;  2QDC A;  1YTS A;  2AZR A;  2I6M A;  2ZN7 A;  4OHI A;  1Q6T A;  3U96 A;  5K22 A;  4RI4 A;  2GJT A;  3ZMQ A;  1C88 A;  4RI5 A;  1ONZ A;  3D1H A;  3QCM A;  2CMA A;  1EEO A;  5BZZ A;  3V0H A;  1ZCK A;  5J8R A;  3GXG A;  2I3R A;  4GS0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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