1PYNA

Dual-site potent, selective protein tyrosine phosphatase 1b inhibitor using a linked fragment strategy and a malonate head on the first site
Total Genus 100
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
282
structure length
282
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Protein-tyrosine phosphatase, non-receptor type 1
total genus 100
structure length 282
sequence length 282
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2003-07-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 1pynA00
3AWEA 4JBCA 5BZZA 1YN9A 2WGPA 4NYHA 1OHDA 1YWFA 1G1GA 1PTUA 3RGOA 3S3EA 2YDUA 2PSZA 5KA1A 1R6HA 1D5RA 2I5XA 3QCJA 1WRMA 3OMHA 2BGEA 4QAHA 2HNPA 2CFVA 5K22A 1OESA 2B4OA 1Q6SA 1PTTA 3O4TA 3BM8A 2NZ6A 3RZ2A 4NX8A 4D3PA 1BZCA 2R0BA 4GE5A 1NWEA 1C84A 1YTNA 4HRFA 1YTWA 1GFYA 3V0JA 1G4WR 5KA9A 3O4SA 3B7OA 2AHSA 3ZM2A 5AWXA 3MOWA 3RO1A 3QCHA 3F99A 5KA0A 4NWGA 2CMCA 3QCNA 3QCEA 1VHRA 3BRHA 1Q6NA 3QCDA 4NNDA 1ZC0A 2FH7A 4RI4A 4YAAA 2Y96A 3QKQA 1XM2A 2VEYA 4QBWA 1I9SA 3I7ZA 4Z6BA 3V0EA 1YPTA 2BZLA 1I9TA 2F6ZA 2I1YA 4RDDA 3F9AA 2GJTA 1PA9A 4TVVA 5KA8A 2NT2A 3F41A 2QDMA 2PT0A 4GE2A 2H03A 1X24A 4Y2EA 3CWEA 3V0DA 2I75A 4WOHA 4KI9A 2J16B 2F6TA 2I4GA 3EZZA 4OHDA 3S3FA 2IMGA 3EAXA 5GTJA 4OHIA 1M3GA 2HVLA 2CNHA 3QCCA 4R0SA 3D9CA 1ECVA 2I6PA 3D1QA 4AZ1A 3PS5A 3NMEA 4RH9A 4Y14A 5KA2A 3ZM1A 1OEOX 2QBQA 4GE6A 4JMKA 4S0GA 2BIJA 3ZM3A 1G1HA 3O3LA 2HC1A 2A3KA 4ZI4A 1PA1A 5KABA 2BGDA 3ZMQA 5I6VA 5KAAA 1C86A 3SR9A 1Q6MA 1FPZA 2QEPA 3A5JA 5KACA 2QCJA 2ZMMA 4JMJA 4QUMA 5BUGA 3M4UA 2Q05A 3I80A 1AAXA 1OHEA 2ZN7A 3D42A 4OHLA 4IKCA 2CNGA 3U96A 5IBMA 4ICZA 1WAXA 5BX1A 4PVGA 1A5YA 2HC2A 1OEUA 2PI7A 3MOZA 2CMBA 3RGQA 2B3OA 1PXHA 2CM7A 4R30A 4KYQA 4I8NA 1C85A 1T49A 2G6ZA 5IBSA 5HDEA 2E0TA 4QBEA 1LARA 1YZ4A 2HY3A 2NTAA 3D1OA 3AWFA 1ZCLA 5K9WA 4ZN5A 3BLUA 2NLKA 2HNQA 2B4SA 1ONZA 4GFVA 4H1OA 4D3RA 1NL9A 1Q6JA 1QZ0A 2I3UA 3QCIA 1U26A 5KA7A 3EU0A 1L8GA 1YGUA 4HJQA 1SUGA 2Y2FA 3V0IA 5EHRA 1YGRA 1EEOA 3GXGA 2I4EA 4PYHA 3EMUA 4GS0A 4J51A 4BJOA 2P6XA 3O5XA 4OHEA 2HXPA 2G59A 1FPRA 2CJZA 1T4JA 2F6YA 3V0HA 1RPMA 1G1FA 1Q6TA 2H04A 4MBBA 2J16A 5J8RA 1V3AA 2H4VA 3F9BA 4WTYA 4WU3A 1P15A 1Q1MA 2OOQA 1MKPA 1ZZWA 2Q47A 1WCHA 3SMEA 1JF7A 1XBOA 3AWGA 1YFOA 1XXVA 2F46A 2VEVA 1I57A 2B4UA 1OEMX 1XRIA 2PQ5A 1Q6PA 2AZRA 2F70A 2H4GA 1U24A 2H02A 3QCLA 4GRYA 4OHHA 3S4OA 2B4PA 1C88A 4JNBA 1JLNA 1GWZA 2VEUA 4ZRTA 5KA4A 2CM3A 3GXHA 2C7SA 1C83A 3BLTA 4GWFA 1U25A 1KAVA 4KYRA 3EB1A 5MMZB 2A8BA 1QXKA 2F6VA 1RXDA 2I6MA 4B04A 5KA3A 3D1HA 3S3KA 1ZCKA 1BZJA 1G7GA 4DGXA 1NWLA 3MMJA 1NO6A 2I3RA 1PYNA 1L8KA 2CM2A 4RKKA 3O4UA 4DGPA 3ZM0A 3OLRA 2CM8A 2F6FA 2P4DA 1J4XA 4GFUA 3ZV2A 2C46A 2GP0A 2SHPA 2B07A 2OC3A 2GWOA 1C87A 5EHPA 1G4US 1LYVA 2PBNA 3N0AA 4HJPA 2CMAA 2H4KA 1FQ1A 2F6WA 4RHGA 5BZXA 1LQFA 3QCKA 3QKPA 2I6IA 3H2XA 4WU2A 2J17A 1EENA 1G7FA 2FJNA 1KAKA 4RI5A 2VEWA 2QCTA 2QBSA 2CNFA 5K25A 2QDPA 2FJMA 4RH5A 3A5KA 1NZ7A 4YR8B 1ONYA 3V0GA 5K24A 2DXPA 2I4HA 2MBCA 2OZ5A 1T48A 4BPCA 4ERCA 2QDCA 3S4EA 2QBPA 1OETA 2I6OA 2HCMA 3S3HA 2CNEA 4GRZA 2VEXA 2CNIA 2QBRA 2NV5A 5K9VA 3I36A 4H34A 4D3QA 2HB1A 2PA5A 5K23A 2I42A 1NNYA 2RF6A 4QAPA 2I6JA 2ESBA 1PTYA 3CM3A 4NWFA 4R0TA 3QCBA 2BV5A 3V0FA 3F81A 1BZHA 1OHCA 4QUNA 5M43A 2B49A 5KADA 2OUDA 1PTVA 5LXQB 1PH0A 2M3VA 1OEVA 3ZMPA 3LJ8A 3QCMA 2NT7A 2F71A 3QCFA 3QCGA 2JJDA 1XXPA 3D44A 1YTSA
chains in the Genus database with same CATH superfamily
3AWEA 4JBCA 5BZZA 1YN9A 4CVMA 2WGPA 4NYHA 1OHDA 1YWFA 1G1GA 1PTUA 3RGOA 3S3EA 2YDUA 2PSZA 5KA1A 1R6HA 1D5RA 3ZM6A 2I5XA 3QCJA 1WRMA 3OMHA 2BGEA 4QAHA 2HNPA 2CFVA 2Y1OA 5K22A 1OESA 2B4OA 2F00A 4BUBA 1Q6SA 1GQQA 1PTTA 3O4TA 3BM8A 2NZ6A 3RZ2A 4NX8A 1FGSA 4D3PA 4HV4A 4UAGA 1BZCA 2R0BA 4GE5A 2WJPA 1NWEA 2Y67A 1C84A 1YTNA 4HRFA 1YTWA 1GFYA 3V0JA 2GCBA 1G4WR 5KA9A 3O4SA 3B7OA 3QCZA 2AHSA 4CVKA 3ZM2A 5AWXA 3MOWA 3RO1A 3QCHA 3F99A 5KA0A 4NWGA 2CMCA 3QCNA 3QCEA 1VHRA 3BRHA 1Q6NA 3QCDA 4NNDA 1ZC0A 2FH7A 4RI4A 4YAAA 2Y96A 3QKQA 1XM2A 2VEYA 4QBWA 1I9SA 2VTDA 1EEHA 3I7ZA 4Z6BA 3V0EA 1YPTA 2BZLA 1I9TA 2F6ZA 2I1YA 4RDDA 3F9AA 2GJTA 1PA9A 4TVVA 5KA8A 2NT2A 2Y68A 3F41A 2QDMA 2PT0A 4GE2A 2H03A 1X24A 4Y2EA 3CWEA 3V0DA 2I75A 3ZM5A 4WOHA 4KI9A 2J16B 2F6TA 2I4GA 3EZZA 4OHDA 3S3FA 2IMGA 3EAXA 5GTJA 4OHIA 1M3GA 2JFHA 2HVLA 2CNHA 3QCCA 4R0SA 2AM1A 3D9CA 1ECVA 2I6PA 3D1QA 4AZ1A 3PS5A 3NMEA 4RH9A 1P31A 4Y14A 5KA2A 3ZM1A 1OEOX 2QBQA 4GE6A 4JMKA 4S0GA 2BIJA 3ZM3A 1G1HA 3O3LA 2HC1A 2A3KA 4ZI4A 1PA1A 5KABA 2BGDA 3ZMQA 5I6VA 1P3DA 5KAAA 1C86A 3SR9A 1Q6MA 1FPZA 2QEPA 3A5JA 5KACA 1W78A 2QCJA 2ZMMA 4JMJA 4QUMA 5BUGA 3M4UA 2Q05A 3NRSA 2XPCA 3I80A 1AAXA 3LK7A 1OHEA 2ZN7A 3D42A 4OHLA 4IKCA 2CNGA 3U96A 5IBMA 4ICZA 1WAXA 5BX1A 1JBVA 4PVGA 1A5YA 2HC2A 2GC6A 1OEUA 2PI7A 3MOZA 2WTZA 4C13A 2CMBA 3RGQA 2B3OA 1PXHA 2CM7A 1W7KA 4KYQA 4R30A 1O5ZA 4I8NA 1C85A 1T49A 2G6ZA 5IBSA 5HDEA 4CVLA 2E0TA 4QBEA 1LARA 1YZ4A 2HY3A 1JBWA 2NTAA 3D1OA 3AWFA 1ZCLA 5K9WA 4ZN5A 3BLUA 1UAGA 2NLKA 4QF5A 3UAGA 2HNQA 2B4SA 1ONZA 4GFVA 4H1OA 4D3RA 2UAGA 1NL9A 1Q6JA 1QZ0A 2I3UA 3QCIA 1U26A 5KA7A 3EU0A 1E0DA 1L8GA 1YGUA 4HJQA 1SUGA 2Y2FA 2VORA 3V0IA 5EHRA 1YGRA 1EEOA 3GXGA 2I4EA 4PYHA 3EMUA 4GS0A 4J51A 4BJOA 2P6XA 3O5XA 4OHEA 2HXPA 2G59A 1FPRA 2CJZA 1T4JA 2F6YA 3V0HA 1RPMA 1G1FA 1Q6TA 2H04A 4MBBA 2J16A 5J8RA 1V3AA 2H4VA 3F9BA 4WTYA 4WU3A 1P15A 1Q1MA 2X5OA 2OOQA 1MKPA 1ZZWA 2Q47A 1WCHA 2AM2A 3SMEA 1JF7A 1XBOA 3AWGA 1YFOA 1XXVA 2F46A 2VEVA 1I57A 2B4UA 1OEMX 1XRIA 2PQ5A 1Q6PA 3MVNA 2AZRA 2F70A 2H4GA 1U24A 2H02A 3QCLA 4GRYA 4OHHA 3S4OA 2B4PA 1C88A 4ZIYA 2GCAA 4JNBA 1JLNA 1GWZA 2VEUA 4ZRTA 5KA4A 2CM3A 3GXHA 2C7SA 1C83A 3BLTA 3ZL8A 2GC5A 4GWFA 1U25A 1KAVA 4KYRA 1J6UA 3EB1A 5MMZB 2A8BA 2Y66A 1QXKA 2F6VA 1RXDA 2I6MA 4B04A 5A5FA 5KA3A 1E8CA 3D1HA 3S3KA 1ZCKA 1BZJA 1G7GA 4DGXA 1NWLA 3MMJA 1NO6A 2I3RA 1PYNA 1L8KA 2CM2A 4RKKA 3O4UA 2JFFA 4DGPA 3ZM0A 3OLRA 2CM8A 2F6FA 2P4DA 1J4XA 4GFUA 3ZV2A 2VOSA 2C46A 2GP0A 2SHPA 2B07A 2OC3A 3PYZA 2GWOA 1C87A 1GQYA 5EHPA 1G4US 1LYVA 2PBNA 3N0AA 4HJPA 2CMAA 2H4KA 1FQ1A 2F6WA 4RHGA 5BZXA 1LQFA 3QCKA 3QKPA 2I6IA 3H2XA 4WU2A 2J17A 1EENA 1G7FA 2FJNA 1KAKA 4RI5A 2VEWA 2QCTA 3N2AA 2QBSA 2CNFA 5K25A 2QDPA 2FJMA 4RH5A 3A5KA 1NZ7A 4YR8B 1ONYA 3V0GA 5K24A 2DXPA 2XJAA 2I4HA 2MBCA 2OZ5A 1GG4A 1T48A 4BPCA 2JFGA 4ERCA 2QDCA 3S4EA 2QBPA 1OETA 2I6OA 2HCMA 3S3HA 2CNEA 4GRZA 2VEXA 2CNIA 2QBRA 2NV5A 5K9VA 3I36A 4H34A 4D3QA 2HB1A 2PA5A 5K23A 2I42A 1NNYA 2RF6A 4C12A 4QAPA 2I6JA 2VTEA 2ESBA 1PTYA 3CM3A 4NWFA 4R0TA 3QCBA 2BV5A 3V0FA 3F81A 1BZHA 5A5EA 1OHCA 3HN7A 4QUNA 5M43A 2B49A 5KADA 2OUDA 1PTVA 5LXQB 1PH0A 2M3VA 1OEVA 4QDIA 3ZMPA 3LJ8A 3QCMA 2NT7A 2F71A 3QCFA 4BUCA 2UUPA 2UUOA 3QCGA 2JJDA 1XXPA 3D44A 1YTSA
chains in the Genus database with same CATH topology
3AWEA 4JBCA 5BZZA 1YN9A 2WGPA 4NYHA 1OHDA 1YWFA 1G1GA 1PTUA 3RGOA 3S3EA 2YDUA 2PSZA 5KA1A 1R6HA 1D5RA 2I5XA 3QCJA 1WRMA 3OMHA 2BGEA 4QAHA 2HNPA 2CFVA 5K22A 1OESA 2B4OA 1Q6SA 1PTTA 3O4TA 3BM8A 2NZ6A 3RZ2A 4NX8A 4D3PA 1BZCA 2R0BA 4GE5A 1NWEA 1C84A 1YTNA 4HRFA 1YTWA 1GFYA 3V0JA 1G4WR 5KA9A 3O4SA 3B7OA 2AHSA 3ZM2A 5AWXA 3MOWA 3RO1A 3QCHA 3F99A 5KA0A 4NWGA 2CMCA 3QCNA 3QCEA 1VHRA 3BRHA 1Q6NA 3QCDA 4NNDA 1ZC0A 2FH7A 4RI4A 4YAAA 2Y96A 3QKQA 1XM2A 2VEYA 4QBWA 1I9SA 3I7ZA 4Z6BA 3V0EA 1YPTA 2BZLA 1I9TA 2F6ZA 2I1YA 4RDDA 3F9AA 2GJTA 1PA9A 4TVVA 5KA8A 2NT2A 3F41A 2QDMA 2PT0A 4GE2A 2H03A 1X24A 4Y2EA 3CWEA 3V0DA 2I75A 4WOHA 4KI9A 2J16B 2F6TA 2I4GA 3EZZA 4OHDA 3S3FA 2IMGA 3EAXA 5GTJA 4OHIA 1M3GA 2HVLA 2CNHA 3QCCA 4R0SA 3D9CA 1ECVA 2I6PA 3D1QA 4AZ1A 3PS5A 3NMEA 4RH9A 4Y14A 5KA2A 3ZM1A 1OEOX 2QBQA 4GE6A 4JMKA 4S0GA 2BIJA 3ZM3A 1G1HA 3O3LA 2HC1A 2A3KA 4ZI4A 1PA1A 5KABA 2BGDA 3ZMQA 5I6VA 5KAAA 1C86A 3SR9A 1Q6MA 1FPZA 2QEPA 3A5JA 5KACA 2QCJA 2ZMMA 4JMJA 4QUMA 5BUGA 3M4UA 2Q05A 3I80A 1AAXA 1OHEA 2ZN7A 3D42A 4OHLA 4IKCA 2CNGA 3U96A 5IBMA 4ICZA 1WAXA 5BX1A 4PVGA 1A5YA 2HC2A 1OEUA 2PI7A 3MOZA 2CMBA 3RGQA 2B3OA 1PXHA 2CM7A 4R30A 4KYQA 4I8NA 1C85A 1T49A 2G6ZA 5IBSA 5HDEA 2E0TA 4QBEA 1LARA 1YZ4A 2HY3A 2NTAA 3D1OA 3AWFA 1ZCLA 5K9WA 4ZN5A 3BLUA 2NLKA 2HNQA 2B4SA 1ONZA 4GFVA 4H1OA 4D3RA 1NL9A 1Q6JA 1QZ0A 2I3UA 3QCIA 1U26A 5KA7A 3EU0A 1L8GA 1YGUA 4HJQA 1SUGA 2Y2FA 3V0IA 5EHRA 1YGRA 1EEOA 3GXGA 2I4EA 4PYHA 3EMUA 4GS0A 4J51A 4BJOA 2P6XA 3O5XA 4OHEA 2HXPA 2G59A 1FPRA 2CJZA 1T4JA 2F6YA 3V0HA 1RPMA 1G1FA 1Q6TA 2H04A 4MBBA 2J16A 5J8RA 1V3AA 2H4VA 3F9BA 4WTYA 4WU3A 1P15A 1Q1MA 2OOQA 1MKPA 1ZZWA 2Q47A 1WCHA 3SMEA 1JF7A 1XBOA 3AWGA 1YFOA 1XXVA 2F46A 2VEVA 1I57A 2B4UA 1OEMX 1XRIA 2PQ5A 1Q6PA 2AZRA 2F70A 2H4GA 1U24A 2H02A 3QCLA 4GRYA 4OHHA 3S4OA 2B4PA 1C88A 4JNBA 1JLNA 1GWZA 2VEUA 4ZRTA 5KA4A 2CM3A 3GXHA 2C7SA 1C83A 3BLTA 4GWFA 1U25A 1KAVA 4KYRA 3EB1A 5MMZB 2A8BA 1QXKA 2F6VA 1RXDA 2I6MA 4B04A 5KA3A 3D1HA 3S3KA 1ZCKA 1BZJA 1G7GA 4DGXA 1NWLA 3MMJA 1NO6A 2I3RA 1PYNA 1L8KA 2CM2A 4RKKA 3O4UA 4DGPA 3ZM0A 3OLRA 2CM8A 2F6FA 2P4DA 1J4XA 4GFUA 3ZV2A 2C46A 2GP0A 2SHPA 2B07A 2OC3A 2GWOA 1C87A 5EHPA 1G4US 1LYVA 2PBNA 3N0AA 4HJPA 2CMAA 2H4KA 1FQ1A 2F6WA 4RHGA 5BZXA 1LQFA 3QCKA 3QKPA 2I6IA 3H2XA 4WU2A 2J17A 1EENA 1G7FA 2FJNA 1KAKA 4RI5A 2VEWA 2QCTA 2QBSA 2CNFA 5K25A 2QDPA 2FJMA 4RH5A 3A5KA 1NZ7A 4YR8B 1ONYA 3V0GA 5K24A 2DXPA 2I4HA 2MBCA 2OZ5A 1T48A 4BPCA 4ERCA 2QDCA 3S4EA 2QBPA 1OETA 2I6OA 2HCMA 3S3HA 2CNEA 4GRZA 2VEXA 2CNIA 2QBRA 2NV5A 5K9VA 3I36A 4H34A 4D3QA 2HB1A 2PA5A 5K23A 2I42A 1NNYA 2RF6A 4QAPA 2I6JA 2ESBA 1PTYA 3CM3A 4NWFA 4R0TA 3QCBA 2BV5A 3V0FA 3F81A 1BZHA 1OHCA 4QUNA 5M43A 2B49A 5KADA 2OUDA 1PTVA 5LXQB 1PH0A 2M3VA 1OEVA 3ZMPA 3LJ8A 3QCMA 2NT7A 2F71A 3QCFA 3QCGA 2JJDA 1XXPA 3D44A 1YTSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3AWE A;  4JBC A;  5BZZ A;  1YN9 A;  2WGP A;  4NYH A;  1OHD A;  1YWF A;  1G1G A;  1PTU A;  3RGO A;  3S3E A;  2YDU A;  2PSZ A;  5KA1 A;  1R6H A;  1D5R A;  2I5X A;  3QCJ A;  1WRM A;  3OMH A;  2BGE A;  4QAH A;  2HNP A;  2CFV A;  5K22 A;  1OES A;  2B4O A;  1Q6S A;  1PTT A;  3O4T A;  3BM8 A;  2NZ6 A;  3RZ2 A;  4NX8 A;  4D3P A;  1BZC A;  2R0B A;  4GE5 A;  1NWE A;  1C84 A;  1YTN A;  4HRF A;  1YTW A;  1GFY A;  3V0J A;  1G4W R;  5KA9 A;  3O4S A;  3B7O A;  2AHS A;  3ZM2 A;  5AWX A;  3MOW A;  3RO1 A;  3QCH A;  3F99 A;  5KA0 A;  4NWG A;  2CMC A;  3QCN A;  3QCE A;  1VHR A;  3BRH A;  1Q6N A;  3QCD A;  4NND A;  1ZC0 A;  2FH7 A;  4RI4 A;  4YAA A;  2Y96 A;  3QKQ A;  1XM2 A;  2VEY A;  4QBW A;  1I9S A;  3I7Z A;  4Z6B A;  3V0E A;  1YPT A;  2BZL A;  1I9T A;  2F6Z A;  2I1Y A;  4RDD A;  3F9A A;  2GJT A;  1PA9 A;  4TVV A;  5KA8 A;  2NT2 A;  3F41 A;  2QDM A;  2PT0 A;  4GE2 A;  2H03 A;  1X24 A;  4Y2E A;  3CWE A;  3V0D A;  2I75 A;  4WOH A;  4KI9 A;  2J16 B;  2F6T A;  2I4G A;  3EZZ A;  4OHD A;  3S3F A;  2IMG A;  3EAX A;  5GTJ A;  4OHI A;  1M3G A;  2HVL A;  2CNH A;  3QCC A;  4R0S A;  3D9C A;  1ECV A;  2I6P A;  3D1Q A;  4AZ1 A;  3PS5 A;  3NME A;  4RH9 A;  4Y14 A;  5KA2 A;  3ZM1 A;  1OEO X;  2QBQ A;  4GE6 A;  4JMK A;  4S0G A;  2BIJ A;  3ZM3 A;  1G1H A;  3O3L A;  2HC1 A;  2A3K A;  4ZI4 A;  1PA1 A;  5KAB A;  2BGD A;  3ZMQ A;  5I6V A;  5KAA A;  1C86 A;  3SR9 A;  1Q6M A;  1FPZ A;  2QEP A;  3A5J A;  5KAC A;  2QCJ A;  2ZMM A;  4JMJ A;  4QUM A;  5BUG A;  3M4U A;  2Q05 A;  3I80 A;  1AAX A;  1OHE A;  2ZN7 A;  3D42 A;  4OHL A;  4IKC A;  2CNG A;  3U96 A;  5IBM A;  4ICZ A;  1WAX A;  5BX1 A;  4PVG A;  1A5Y A;  2HC2 A;  1OEU A;  2PI7 A;  3MOZ A;  2CMB A;  3RGQ A;  2B3O A;  1PXH A;  2CM7 A;  4R30 A;  4KYQ A;  4I8N A;  1C85 A;  1T49 A;  2G6Z A;  5IBS A;  5HDE A;  2E0T A;  4QBE A;  1LAR A;  1YZ4 A;  2HY3 A;  2NTA A;  3D1O A;  3AWF A;  1ZCL A;  5K9W A;  4ZN5 A;  3BLU A;  2NLK A;  2HNQ A;  2B4S A;  1ONZ A;  4GFV A;  4H1O A;  4D3R A;  1NL9 A;  1Q6J A;  1QZ0 A;  2I3U A;  3QCI A;  1U26 A;  5KA7 A;  3EU0 A;  1L8G A;  1YGU A;  4HJQ A;  1SUG A;  2Y2F A;  3V0I A;  5EHR A;  1YGR A;  1EEO A;  3GXG A;  2I4E A;  4PYH A;  3EMU A;  4GS0 A;  4J51 A;  4BJO A;  2P6X A;  3O5X A;  4OHE A;  2HXP A;  2G59 A;  1FPR A;  2CJZ A;  1T4J A;  2F6Y A;  3V0H A;  1RPM A;  1G1F A;  1Q6T A;  2H04 A;  4MBB A;  2J16 A;  5J8R A;  1V3A A;  2H4V A;  3F9B A;  4WTY A;  4WU3 A;  1P15 A;  1Q1M A;  2OOQ A;  1MKP A;  1ZZW A;  2Q47 A;  1WCH A;  3SME A;  1JF7 A;  1XBO A;  3AWG A;  1YFO A;  1XXV A;  2F46 A;  2VEV A;  1I57 A;  2B4U A;  1OEM X;  1XRI A;  2PQ5 A;  1Q6P A;  2AZR A;  2F70 A;  2H4G A;  1U24 A;  2H02 A;  3QCL A;  4GRY A;  4OHH A;  3S4O A;  2B4P A;  1C88 A;  4JNB A;  1JLN A;  1GWZ A;  2VEU A;  4ZRT A;  5KA4 A;  2CM3 A;  3GXH A;  2C7S A;  1C83 A;  3BLT A;  4GWF A;  1U25 A;  1KAV A;  4KYR A;  3EB1 A;  5MMZ B;  2A8B A;  1QXK A;  2F6V A;  1RXD A;  2I6M A;  4B04 A;  5KA3 A;  3D1H A;  3S3K A;  1ZCK A;  1BZJ A;  1G7G A;  4DGX A;  1NWL A;  3MMJ A;  1NO6 A;  2I3R A;  1PYN A;  1L8K A;  2CM2 A;  4RKK A;  3O4U A;  4DGP A;  3ZM0 A;  3OLR A;  2CM8 A;  2F6F A;  2P4D A;  1J4X A;  4GFU A;  3ZV2 A;  2C46 A;  2GP0 A;  2SHP A;  2B07 A;  2OC3 A;  2GWO A;  1C87 A;  5EHP A;  1G4U S;  1LYV A;  2PBN A;  3N0A A;  4HJP A;  2CMA A;  2H4K A;  1FQ1 A;  2F6W A;  4RHG A;  5BZX A;  1LQF A;  3QCK A;  3QKP A;  2I6I A;  3H2X A;  4WU2 A;  2J17 A;  1EEN A;  1G7F A;  2FJN A;  1KAK A;  4RI5 A;  2VEW A;  2QCT A;  2QBS A;  2CNF A;  5K25 A;  2QDP A;  2FJM A;  4RH5 A;  3A5K A;  1NZ7 A;  4YR8 B;  1ONY A;  3V0G A;  5K24 A;  2DXP A;  2I4H A;  2MBC A;  2OZ5 A;  1T48 A;  4BPC A;  4ERC A;  2QDC A;  3S4E A;  2QBP A;  1OET A;  2I6O A;  2HCM A;  3S3H A;  2CNE A;  4GRZ A;  2VEX A;  2CNI A;  2QBR A;  2NV5 A;  5K9V A;  3I36 A;  4H34 A;  4D3Q A;  2HB1 A;  2PA5 A;  5K23 A;  2I42 A;  1NNY A;  2RF6 A;  4QAP A;  2I6J A;  2ESB A;  1PTY A;  3CM3 A;  4NWF A;  4R0T A;  3QCB A;  2BV5 A;  3V0F A;  3F81 A;  1BZH A;  1OHC A;  4QUN A;  5M43 A;  2B49 A;  5KAD A;  2OUD A;  1PTV A;  5LXQ B;  1PH0 A;  2M3V A;  1OEV A;  3ZMP A;  3LJ8 A;  3QCM A;  2NT7 A;  2F71 A;  3QCF A;  3QCG A;  2JJD A;  1XXP A;  3D44 A;  1YTS A; 
#chains in the Genus database with same CATH topology
 3AWE A;  4JBC A;  5BZZ A;  1YN9 A;  4CVM A;  2WGP A;  4NYH A;  1OHD A;  1YWF A;  1G1G A;  1PTU A;  3RGO A;  3S3E A;  2YDU A;  2PSZ A;  5KA1 A;  1R6H A;  1D5R A;  3ZM6 A;  2I5X A;  3QCJ A;  1WRM A;  3OMH A;  2BGE A;  4QAH A;  2HNP A;  2CFV A;  2Y1O A;  5K22 A;  1OES A;  2B4O A;  2F00 A;  4BUB A;  1Q6S A;  1GQQ A;  1PTT A;  3O4T A;  3BM8 A;  2NZ6 A;  3RZ2 A;  4NX8 A;  1FGS A;  4D3P A;  4HV4 A;  4UAG A;  1BZC A;  2R0B A;  4GE5 A;  2WJP A;  1NWE A;  2Y67 A;  1C84 A;  1YTN A;  4HRF A;  1YTW A;  1GFY A;  3V0J A;  2GCB A;  1G4W R;  5KA9 A;  3O4S A;  3B7O A;  3QCZ A;  2AHS A;  4CVK A;  3ZM2 A;  5AWX A;  3MOW A;  3RO1 A;  3QCH A;  3F99 A;  5KA0 A;  4NWG A;  2CMC A;  3QCN A;  3QCE A;  1VHR A;  3BRH A;  1Q6N A;  3QCD A;  4NND A;  1ZC0 A;  2FH7 A;  4RI4 A;  4YAA A;  2Y96 A;  3QKQ A;  1XM2 A;  2VEY A;  4QBW A;  1I9S A;  2VTD A;  1EEH A;  3I7Z A;  4Z6B A;  3V0E A;  1YPT A;  2BZL A;  1I9T A;  2F6Z A;  2I1Y A;  4RDD A;  3F9A A;  2GJT A;  1PA9 A;  4TVV A;  5KA8 A;  2NT2 A;  2Y68 A;  3F41 A;  2QDM A;  2PT0 A;  4GE2 A;  2H03 A;  1X24 A;  4Y2E A;  3CWE A;  3V0D A;  2I75 A;  3ZM5 A;  4WOH A;  4KI9 A;  2J16 B;  2F6T A;  2I4G A;  3EZZ A;  4OHD A;  3S3F A;  2IMG A;  3EAX A;  5GTJ A;  4OHI A;  1M3G A;  2JFH A;  2HVL A;  2CNH A;  3QCC A;  4R0S A;  2AM1 A;  3D9C A;  1ECV A;  2I6P A;  3D1Q A;  4AZ1 A;  3PS5 A;  3NME A;  4RH9 A;  1P31 A;  4Y14 A;  5KA2 A;  3ZM1 A;  1OEO X;  2QBQ A;  4GE6 A;  4JMK A;  4S0G A;  2BIJ A;  3ZM3 A;  1G1H A;  3O3L A;  2HC1 A;  2A3K A;  4ZI4 A;  1PA1 A;  5KAB A;  2BGD A;  3ZMQ A;  5I6V A;  1P3D A;  5KAA A;  1C86 A;  3SR9 A;  1Q6M A;  1FPZ A;  2QEP A;  3A5J A;  5KAC A;  1W78 A;  2QCJ A;  2ZMM A;  4JMJ A;  4QUM A;  5BUG A;  3M4U A;  2Q05 A;  3NRS A;  2XPC A;  3I80 A;  1AAX A;  3LK7 A;  1OHE A;  2ZN7 A;  3D42 A;  4OHL A;  4IKC A;  2CNG A;  3U96 A;  5IBM A;  4ICZ A;  1WAX A;  5BX1 A;  1JBV A;  4PVG A;  1A5Y A;  2HC2 A;  2GC6 A;  1OEU A;  2PI7 A;  3MOZ A;  2WTZ A;  4C13 A;  2CMB A;  3RGQ A;  2B3O A;  1PXH A;  2CM7 A;  1W7K A;  4KYQ A;  4R30 A;  1O5Z A;  4I8N A;  1C85 A;  1T49 A;  2G6Z A;  5IBS A;  5HDE A;  4CVL A;  2E0T A;  4QBE A;  1LAR A;  1YZ4 A;  2HY3 A;  1JBW A;  2NTA A;  3D1O A;  3AWF A;  1ZCL A;  5K9W A;  4ZN5 A;  3BLU A;  1UAG A;  2NLK A;  4QF5 A;  3UAG A;  2HNQ A;  2B4S A;  1ONZ A;  4GFV A;  4H1O A;  4D3R A;  2UAG A;  1NL9 A;  1Q6J A;  1QZ0 A;  2I3U A;  3QCI A;  1U26 A;  5KA7 A;  3EU0 A;  1E0D A;  1L8G A;  1YGU A;  4HJQ A;  1SUG A;  2Y2F A;  2VOR A;  3V0I A;  5EHR A;  1YGR A;  1EEO A;  3GXG A;  2I4E A;  4PYH A;  3EMU A;  4GS0 A;  4J51 A;  4BJO A;  2P6X A;  3O5X A;  4OHE A;  2HXP A;  2G59 A;  1FPR A;  2CJZ A;  1T4J A;  2F6Y A;  3V0H A;  1RPM A;  1G1F A;  1Q6T A;  2H04 A;  4MBB A;  2J16 A;  5J8R A;  1V3A A;  2H4V A;  3F9B A;  4WTY A;  4WU3 A;  1P15 A;  1Q1M A;  2X5O A;  2OOQ A;  1MKP A;  1ZZW A;  2Q47 A;  1WCH A;  2AM2 A;  3SME A;  1JF7 A;  1XBO A;  3AWG A;  1YFO A;  1XXV A;  2F46 A;  2VEV A;  1I57 A;  2B4U A;  1OEM X;  1XRI A;  2PQ5 A;  1Q6P A;  3MVN A;  2AZR A;  2F70 A;  2H4G A;  1U24 A;  2H02 A;  3QCL A;  4GRY A;  4OHH A;  3S4O A;  2B4P A;  1C88 A;  4ZIY A;  2GCA A;  4JNB A;  1JLN A;  1GWZ A;  2VEU A;  4ZRT A;  5KA4 A;  2CM3 A;  3GXH A;  2C7S A;  1C83 A;  3BLT A;  3ZL8 A;  2GC5 A;  4GWF A;  1U25 A;  1KAV A;  4KYR A;  1J6U A;  3EB1 A;  5MMZ B;  2A8B A;  2Y66 A;  1QXK A;  2F6V A;  1RXD A;  2I6M A;  4B04 A;  5A5F A;  5KA3 A;  1E8C A;  3D1H A;  3S3K A;  1ZCK A;  1BZJ A;  1G7G A;  4DGX A;  1NWL A;  3MMJ A;  1NO6 A;  2I3R A;  1PYN A;  1L8K A;  2CM2 A;  4RKK A;  3O4U A;  2JFF A;  4DGP A;  3ZM0 A;  3OLR A;  2CM8 A;  2F6F A;  2P4D A;  1J4X A;  4GFU A;  3ZV2 A;  2VOS A;  2C46 A;  2GP0 A;  2SHP A;  2B07 A;  2OC3 A;  3PYZ A;  2GWO A;  1C87 A;  1GQY A;  5EHP A;  1G4U S;  1LYV A;  2PBN A;  3N0A A;  4HJP A;  2CMA A;  2H4K A;  1FQ1 A;  2F6W A;  4RHG A;  5BZX A;  1LQF A;  3QCK A;  3QKP A;  2I6I A;  3H2X A;  4WU2 A;  2J17 A;  1EEN A;  1G7F A;  2FJN A;  1KAK A;  4RI5 A;  2VEW A;  2QCT A;  3N2A A;  2QBS A;  2CNF A;  5K25 A;  2QDP A;  2FJM A;  4RH5 A;  3A5K A;  1NZ7 A;  4YR8 B;  1ONY A;  3V0G A;  5K24 A;  2DXP A;  2XJA A;  2I4H A;  2MBC A;  2OZ5 A;  1GG4 A;  1T48 A;  4BPC A;  2JFG A;  4ERC A;  2QDC A;  3S4E A;  2QBP A;  1OET A;  2I6O A;  2HCM A;  3S3H A;  2CNE A;  4GRZ A;  2VEX A;  2CNI A;  2QBR A;  2NV5 A;  5K9V A;  3I36 A;  4H34 A;  4D3Q A;  2HB1 A;  2PA5 A;  5K23 A;  2I42 A;  1NNY A;  2RF6 A;  4C12 A;  4QAP A;  2I6J A;  2VTE A;  2ESB A;  1PTY A;  3CM3 A;  4NWF A;  4R0T A;  3QCB A;  2BV5 A;  3V0F A;  3F81 A;  1BZH A;  5A5E A;  1OHC A;  3HN7 A;  4QUN A;  5M43 A;  2B49 A;  5KAD A;  2OUD A;  1PTV A;  5LXQ B;  1PH0 A;  2M3V A;  1OEV A;  4QDI A;  3ZMP A;  3LJ8 A;  3QCM A;  2NT7 A;  2F71 A;  3QCF A;  4BUC A;  2UUP A;  2UUO A;  3QCG A;  2JJD A;  1XXP A;  3D44 A;  1YTS A; 
#chains in the Genus database with same CATH homology
 3AWE A;  4JBC A;  5BZZ A;  1YN9 A;  2WGP A;  4NYH A;  1OHD A;  1YWF A;  1G1G A;  1PTU A;  3RGO A;  3S3E A;  2YDU A;  2PSZ A;  5KA1 A;  1R6H A;  1D5R A;  2I5X A;  3QCJ A;  1WRM A;  3OMH A;  2BGE A;  4QAH A;  2HNP A;  2CFV A;  5K22 A;  1OES A;  2B4O A;  1Q6S A;  1PTT A;  3O4T A;  3BM8 A;  2NZ6 A;  3RZ2 A;  4NX8 A;  4D3P A;  1BZC A;  2R0B A;  4GE5 A;  1NWE A;  1C84 A;  1YTN A;  4HRF A;  1YTW A;  1GFY A;  3V0J A;  1G4W R;  5KA9 A;  3O4S A;  3B7O A;  2AHS A;  3ZM2 A;  5AWX A;  3MOW A;  3RO1 A;  3QCH A;  3F99 A;  5KA0 A;  4NWG A;  2CMC A;  3QCN A;  3QCE A;  1VHR A;  3BRH A;  1Q6N A;  3QCD A;  4NND A;  1ZC0 A;  2FH7 A;  4RI4 A;  4YAA A;  2Y96 A;  3QKQ A;  1XM2 A;  2VEY A;  4QBW A;  1I9S A;  3I7Z A;  4Z6B A;  3V0E A;  1YPT A;  2BZL A;  1I9T A;  2F6Z A;  2I1Y A;  4RDD A;  3F9A A;  2GJT A;  1PA9 A;  4TVV A;  5KA8 A;  2NT2 A;  3F41 A;  2QDM A;  2PT0 A;  4GE2 A;  2H03 A;  1X24 A;  4Y2E A;  3CWE A;  3V0D A;  2I75 A;  4WOH A;  4KI9 A;  2J16 B;  2F6T A;  2I4G A;  3EZZ A;  4OHD A;  3S3F A;  2IMG A;  3EAX A;  5GTJ A;  4OHI A;  1M3G A;  2HVL A;  2CNH A;  3QCC A;  4R0S A;  3D9C A;  1ECV A;  2I6P A;  3D1Q A;  4AZ1 A;  3PS5 A;  3NME A;  4RH9 A;  4Y14 A;  5KA2 A;  3ZM1 A;  1OEO X;  2QBQ A;  4GE6 A;  4JMK A;  4S0G A;  2BIJ A;  3ZM3 A;  1G1H A;  3O3L A;  2HC1 A;  2A3K A;  4ZI4 A;  1PA1 A;  5KAB A;  2BGD A;  3ZMQ A;  5I6V A;  5KAA A;  1C86 A;  3SR9 A;  1Q6M A;  1FPZ A;  2QEP A;  3A5J A;  5KAC A;  2QCJ A;  2ZMM A;  4JMJ A;  4QUM A;  5BUG A;  3M4U A;  2Q05 A;  3I80 A;  1AAX A;  1OHE A;  2ZN7 A;  3D42 A;  4OHL A;  4IKC A;  2CNG A;  3U96 A;  5IBM A;  4ICZ A;  1WAX A;  5BX1 A;  4PVG A;  1A5Y A;  2HC2 A;  1OEU A;  2PI7 A;  3MOZ A;  2CMB A;  3RGQ A;  2B3O A;  1PXH A;  2CM7 A;  4R30 A;  4KYQ A;  4I8N A;  1C85 A;  1T49 A;  2G6Z A;  5IBS A;  5HDE A;  2E0T A;  4QBE A;  1LAR A;  1YZ4 A;  2HY3 A;  2NTA A;  3D1O A;  3AWF A;  1ZCL A;  5K9W A;  4ZN5 A;  3BLU A;  2NLK A;  2HNQ A;  2B4S A;  1ONZ A;  4GFV A;  4H1O A;  4D3R A;  1NL9 A;  1Q6J A;  1QZ0 A;  2I3U A;  3QCI A;  1U26 A;  5KA7 A;  3EU0 A;  1L8G A;  1YGU A;  4HJQ A;  1SUG A;  2Y2F A;  3V0I A;  5EHR A;  1YGR A;  1EEO A;  3GXG A;  2I4E A;  4PYH A;  3EMU A;  4GS0 A;  4J51 A;  4BJO A;  2P6X A;  3O5X A;  4OHE A;  2HXP A;  2G59 A;  1FPR A;  2CJZ A;  1T4J A;  2F6Y A;  3V0H A;  1RPM A;  1G1F A;  1Q6T A;  2H04 A;  4MBB A;  2J16 A;  5J8R A;  1V3A A;  2H4V A;  3F9B A;  4WTY A;  4WU3 A;  1P15 A;  1Q1M A;  2OOQ A;  1MKP A;  1ZZW A;  2Q47 A;  1WCH A;  3SME A;  1JF7 A;  1XBO A;  3AWG A;  1YFO A;  1XXV A;  2F46 A;  2VEV A;  1I57 A;  2B4U A;  1OEM X;  1XRI A;  2PQ5 A;  1Q6P A;  2AZR A;  2F70 A;  2H4G A;  1U24 A;  2H02 A;  3QCL A;  4GRY A;  4OHH A;  3S4O A;  2B4P A;  1C88 A;  4JNB A;  1JLN A;  1GWZ A;  2VEU A;  4ZRT A;  5KA4 A;  2CM3 A;  3GXH A;  2C7S A;  1C83 A;  3BLT A;  4GWF A;  1U25 A;  1KAV A;  4KYR A;  3EB1 A;  5MMZ B;  2A8B A;  1QXK A;  2F6V A;  1RXD A;  2I6M A;  4B04 A;  5KA3 A;  3D1H A;  3S3K A;  1ZCK A;  1BZJ A;  1G7G A;  4DGX A;  1NWL A;  3MMJ A;  1NO6 A;  2I3R A;  1PYN A;  1L8K A;  2CM2 A;  4RKK A;  3O4U A;  4DGP A;  3ZM0 A;  3OLR A;  2CM8 A;  2F6F A;  2P4D A;  1J4X A;  4GFU A;  3ZV2 A;  2C46 A;  2GP0 A;  2SHP A;  2B07 A;  2OC3 A;  2GWO A;  1C87 A;  5EHP A;  1G4U S;  1LYV A;  2PBN A;  3N0A A;  4HJP A;  2CMA A;  2H4K A;  1FQ1 A;  2F6W A;  4RHG A;  5BZX A;  1LQF A;  3QCK A;  3QKP A;  2I6I A;  3H2X A;  4WU2 A;  2J17 A;  1EEN A;  1G7F A;  2FJN A;  1KAK A;  4RI5 A;  2VEW A;  2QCT A;  2QBS A;  2CNF A;  5K25 A;  2QDP A;  2FJM A;  4RH5 A;  3A5K A;  1NZ7 A;  4YR8 B;  1ONY A;  3V0G A;  5K24 A;  2DXP A;  2I4H A;  2MBC A;  2OZ5 A;  1T48 A;  4BPC A;  4ERC A;  2QDC A;  3S4E A;  2QBP A;  1OET A;  2I6O A;  2HCM A;  3S3H A;  2CNE A;  4GRZ A;  2VEX A;  2CNI A;  2QBR A;  2NV5 A;  5K9V A;  3I36 A;  4H34 A;  4D3Q A;  2HB1 A;  2PA5 A;  5K23 A;  2I42 A;  1NNY A;  2RF6 A;  4QAP A;  2I6J A;  2ESB A;  1PTY A;  3CM3 A;  4NWF A;  4R0T A;  3QCB A;  2BV5 A;  3V0F A;  3F81 A;  1BZH A;  1OHC A;  4QUN A;  5M43 A;  2B49 A;  5KAD A;  2OUD A;  1PTV A;  5LXQ B;  1PH0 A;  2M3V A;  1OEV A;  3ZMP A;  3LJ8 A;  3QCM A;  2NT7 A;  2F71 A;  3QCF A;  3QCG A;  2JJD A;  1XXP A;  3D44 A;  1YTS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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