1Q1MA

A highly efficient approach to a selective and cell active ptp1b inhibitors
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
298
structure length
298
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Protein-tyrosine phosphatase, non-receptor type 1
total genus 107
structure length 298
sequence length 298
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2003-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 1q1mA00
4KYRA 1YFOA 2I42A 2B3OA 4OHEA 2QDMA 4DGXA 2J17A 2VEUA 3ZMPA 3S3FA 2FJMA 2HNQA 3QCJA 3AWEA 2MBCA 2QEPA 1ZCKA 3I7ZA 1T49A 3AWGA 2CJZA 2I6PA 5K9WA 4PVGA 2WGPA 3QCLA 5BUGA 3S3EA 4Y14A 1J4XA 4YAAA 5KA9A 3QCKA 4BPCA 3CM3A 4ZN5A 3SMEA 3V0DA 1LYVA 1P15A 2NZ6A 1BZCA 4WOHA 2H03A 2H04A 2QBQA 1Q6PA 1YTWA 4GFVA 3O4TA 1I57A 4JMKA 3S4OA 1LQFA 2I3RA 1OETA 2AZRA 5IBSA 1G7FA 2PSZA 5K25A 3MOZA 3MOWA 4ICZA 5KA4A 4JNBA 1YTNA 1T4JA 1EENA 5KADA 1ECVA 3F9AA 1FQ1A 2F71A 3D1QA 3RGOA 2I1YA 4JMJA 2PA5A 4B04A 2BV5A 1XM2A 1NNYA 4MBBA 1PH0A 3RO1A 4RDDA 2BIJA 2CMAA 2ESBA 4S0GA 4QAHA 1NZ7A 3PS5A 1GFYA 5KABA 2CNIA 3F41A 3A5JA 3OLRA 4KI9A 4R0SA 1JLNA 2F6VA 4QUNA 4GRZA 4QAPA 3S3HA 5K9VA 2NTAA 2PT0A 1PTUA 1G4US 1ZC0A 3S3KA 4JBCA 2BGDA 2GJTA 3BM8A 4I8NA 3BRHA 4GE6A 3A5KA 5EHPA 2I6MA 2OZ5A 1WCHA 1EEOA 5HDEA 3OMHA 1NWLA 1Q1MA 1I9TA 2M3VA 2I4GA 2VEYA 5KA8A 1LARA 4Y2EA 4Z6BA 1PXHA 2DXPA 3V0IA 3QCEA 3BLTA 1BZJA 3D9CA 2H4KA 3V0EA 3EU0A 2I6JA 4GFUA 2YDUA 4RI5A 2F70A 1NL9A 2G59A 3QCHA 4BJOA 4GWFA 1YPTA 4KYQA 1RPMA 3MMJA 1WAXA 3O3LA 4OHIA 2BGEA 2I75A 3V0GA 2QDCA 3QCNA 1MKPA 2I6OA 1G4WR 2Q47A 1G7GA 1PA1A 1OEUA 1V3AA 3QCIA 2I4EA 3D42A 3QKPA 3D44A 2NV5A 2ZN7A 2QCJA 3F81A 1PTVA 3N0AA 3EMUA 3O4UA 4D3RA 3O4SA 5K23A 4OHDA 3QCGA 1FPZA 2HCMA 5KA1A 3M4UA 4RH5A 5KA2A 5IBMA 4RI4A 5KA7A 4GRYA 1XBOA 1Q6TA 4ERCA 1KAVA 1D5RA 1C84A 4R30A 4D3PA 3GXHA 2CNEA 2QDPA 2P6XA 2B4PA 1SUGA 5K24A 1L8GA 2R0BA 1R6HA 1VHRA 3GXGA 5K22A 1G1HA 1OEVA 5M43A 1M3GA 1XRIA 4ZI4A 2H4VA 3H2XA 3QKQA 1XXPA 2E0TA 3EZZA 2F46A 5I6VA 1QXKA 4WTYA 1C83A 2CM3A 1NWEA 3ZMQA 1A5YA 4WU3A 3S4EA 1FPRA 1Q6JA 2Q05A 4NYHA 5KACA 2FH7A 4IKCA 1OEMX 2CM7A 2HVLA 3I36A 5KA0A 2IMGA 1G1FA 1XXVA 1OESA 2F6YA 2QBPA 5KAAA 2PI7A 5BZZA 1U24A 3ZV2A 4NNDA 1PYNA 3QCFA 2HC1A 4DGPA 1KAKA 2JJDA 4NWFA 3U96A 2B4SA 2NT7A 4J51A 4NX8A 2HC2A 1ONYA 1YWFA 4RKKA 2F6TA 4ZRTA 2B49A 1YGRA 2A3KA 4RHGA 2G6ZA 2H4GA 3F9BA 4H34A 4AZ1A 5EHRA 2NLKA 2QBSA 1QZ0A 2Y2FA 4HRFA 3V0HA 1PTYA 3RZ2A 2ZMMA 2FJNA 4TVVA 3NMEA 1ZCLA 1Q6NA 4QUMA 3V0FA 2OOQA 1X24A 3QCDA 3F99A 5MMZB 4D3QA 2CNGA 4HJPA 2F6ZA 1WRMA 4QBEA 1YTSA 1JF7A 1PTTA 1OHCA 4GE5A 3D1HA 1C87A 1GWZA 2CMCA 1OEOX 4RH9A 3QCBA 2OUDA 1C85A 1YZ4A 2B4UA 4GS0A 2HB1A 2A8BA 3ZM3A 1ONZA 2VEXA 1L8KA 2QCTA 3LJ8A 4NWGA 1AAXA 4HJQA 2NT2A 2PQ5A 1ZZWA 1YGUA 2C7SA 4H1OA 4GE2A 4PYHA 2Y96A 2B4OA 3V0JA 1I9SA 4WU2A 2I6IA 2J16B 5BZXA 3O5XA 3CWEA 2CM2A 1PA9A 3RGQA 5KA3A 2F6FA 2C46A 2HXPA 3AWFA 2BZLA 2J16A 5LXQB 2CNFA 1OHEA 2I3UA 3ZM1A 3BLUA 2HNPA 2CMBA 2CFVA 3EAXA 4QBWA 2QBRA 4OHHA 2VEVA 3D1OA 5GTJA 1G1GA 1Q6SA 2B07A 3ZM0A 1T48A 1OHDA 2SHPA 1YN9A 5J8RA 2HY3A 2VEWA 3ZM2A 2I4HA 2H02A 2I5XA 4YR8B 1Q6MA 3EB1A 3QCCA 1BZHA 1U25A 2AHSA 5AWXA 2RF6A 5BX1A 2CNHA 3SR9A 1RXDA 2F6WA 2CM8A 1NO6A 2P4DA 3QCMA 2OC3A 2GWOA 1U26A 4R0TA 2GP0A 2PBNA 1C88A 3B7OA 4OHLA 3I80A 1C86A
chains in the Genus database with same CATH superfamily
3NRSA 4KYRA 1YFOA 2I42A 4BUCA 2B3OA 5A5FA 4OHEA 2QDMA 4DGXA 2J17A 2VEUA 3ZMPA 3S3FA 2FJMA 2HNQA 3QCJA 4HV4A 3AWEA 2MBCA 2QEPA 1ZCKA 3I7ZA 1T49A 3AWGA 2CJZA 2I6PA 5K9WA 4PVGA 2WGPA 3QCLA 5BUGA 3S3EA 4Y14A 1J4XA 4YAAA 5KA9A 3QCKA 4BPCA 3CM3A 4ZN5A 3SMEA 3V0DA 1LYVA 1P15A 2NZ6A 1BZCA 3MVNA 4WOHA 2H03A 2H04A 1O5ZA 2QBQA 1Q6PA 2WTZA 1YTWA 4GFVA 3O4TA 1I57A 4JMKA 3S4OA 1LQFA 2I3RA 1OETA 2AZRA 5IBSA 1G7FA 2PSZA 5K25A 3MOZA 3MOWA 4ICZA 5KA4A 1GQQA 4JNBA 1YTNA 1T4JA 1EENA 5KADA 1ECVA 3F9AA 1FQ1A 2F71A 3D1QA 4UAGA 3RGOA 2I1YA 4JMJA 2PA5A 4B04A 2BV5A 1XM2A 1NNYA 4MBBA 1PH0A 3RO1A 4RDDA 2BIJA 2CMAA 2ESBA 4S0GA 4QAHA 1NZ7A 3PS5A 1GFYA 5KABA 2CNIA 3F41A 3A5JA 3PYZA 4BUBA 3OLRA 4KI9A 4R0SA 1JLNA 2F6VA 4QUNA 4GRZA 4QAPA 3S3HA 5K9VA 2NTAA 2PT0A 1PTUA 1G4US 1ZC0A 3S3KA 4JBCA 2VTDA 2BGDA 2GJTA 3BM8A 4I8NA 3BRHA 4GE6A 3A5KA 5EHPA 4C13A 2I6MA 2OZ5A 1WCHA 4C12A 1EEOA 5HDEA 1JBVA 3OMHA 1NWLA 1Q1MA 1I9TA 2M3VA 2JFHA 2I4GA 2VEYA 5KA8A 1LARA 4Y2EA 4Z6BA 1PXHA 2DXPA 3V0IA 3QCEA 3BLTA 1BZJA 4CVLA 3D9CA 2H4KA 3V0EA 2UAGA 3EU0A 2AM1A 2I6JA 5A5EA 4GFUA 2YDUA 4RI5A 2F70A 1NL9A 2G59A 3UAGA 3QCHA 4BJOA 4GWFA 1YPTA 4KYQA 1RPMA 3MMJA 1WAXA 3O3LA 4OHIA 2BGEA 3ZM6A 2I75A 3V0GA 2QDCA 3LK7A 3QCNA 1MKPA 2I6OA 1G4WR 2Q47A 1G7GA 1PA1A 1OEUA 1V3AA 3QCIA 2GC6A 2Y67A 2AM2A 2I4EA 3D42A 3QKPA 3D44A 2NV5A 2ZN7A 2QCJA 3F81A 2JFGA 1PTVA 3N0AA 3EMUA 3O4UA 2GCAA 4D3RA 1P31A 3O4SA 5K23A 4OHDA 3QCGA 1FPZA 4QF5A 2HCMA 5KA1A 3M4UA 2F00A 4RH5A 5KA2A 5IBMA 1P3DA 4RI4A 5KA7A 2X5OA 1E0DA 2Y66A 4GRYA 1XBOA 1Q6TA 4ERCA 1KAVA 1D5RA 1C84A 2UUPA 4R30A 4D3PA 3GXHA 2CNEA 2QDPA 2P6XA 2B4PA 1SUGA 5K24A 4CVMA 1L8GA 2R0BA 1R6HA 1VHRA 3GXGA 5K22A 1G1HA 1OEVA 5M43A 1M3GA 1XRIA 4ZI4A 1W78A 2H4VA 3H2XA 3QKQA 1XXPA 1GQYA 2E0TA 3EZZA 2F46A 2XPCA 5I6VA 1QXKA 4WTYA 2GCBA 1C83A 2CM3A 1NWEA 3ZMQA 1A5YA 4WU3A 3S4EA 1FPRA 1Q6JA 2JFFA 2Q05A 4NYHA 5KACA 2FH7A 3HN7A 4IKCA 3ZM5A 1OEMX 2CM7A 2HVLA 3I36A 5KA0A 2IMGA 1G1FA 1XXVA 1OESA 2F6YA 2QBPA 5KAAA 2PI7A 3N2AA 5BZZA 1U24A 3ZV2A 4NNDA 1PYNA 3QCFA 2HC1A 4DGPA 1KAKA 2JJDA 4NWFA 3U96A 2B4SA 2NT7A 4J51A 4NX8A 2HC2A 1ONYA 1YWFA 4RKKA 2F6TA 1JBWA 4ZRTA 2B49A 1YGRA 2A3KA 4RHGA 2G6ZA 2H4GA 3F9BA 4H34A 4AZ1A 3QCZA 3ZL8A 5EHRA 2NLKA 2QBSA 1QZ0A 2Y2FA 4HRFA 2VORA 3V0HA 1PTYA 3RZ2A 2ZMMA 2FJNA 4TVVA 3NMEA 1ZCLA 1Q6NA 4QUMA 3V0FA 2OOQA 1X24A 3QCDA 3F99A 5MMZB 4D3QA 2CNGA 4HJPA 2F6ZA 1WRMA 4QBEA 1YTSA 4QDIA 1JF7A 2Y1OA 1PTTA 1OHCA 4GE5A 3D1HA 1C87A 1GWZA 2CMCA 1J6UA 1OEOX 4RH9A 2Y68A 3QCBA 2OUDA 1C85A 1YZ4A 2B4UA 4GS0A 2HB1A 2A8BA 3ZM3A 1E8CA 1ONZA 2VEXA 1L8KA 2QCTA 3LJ8A 4NWGA 1AAXA 4HJQA 2NT2A 2PQ5A 1EEHA 1ZZWA 1YGUA 2C7SA 4H1OA 2WJPA 4GE2A 4PYHA 2Y96A 2B4OA 3V0JA 1I9SA 4WU2A 2I6IA 2J16B 5BZXA 3O5XA 3CWEA 2CM2A 1FGSA 1PA9A 3RGQA 5KA3A 2F6FA 2C46A 2HXPA 3AWFA 2BZLA 2J16A 5LXQB 2CNFA 1UAGA 4ZIYA 1OHEA 2I3UA 3ZM1A 1GG4A 2GC5A 3BLUA 2HNPA 2CMBA 2CFVA 3EAXA 4QBWA 2QBRA 4OHHA 2VEVA 3D1OA 5GTJA 1G1GA 1Q6SA 2B07A 3ZM0A 1T48A 1OHDA 2SHPA 1YN9A 5J8RA 2HY3A 2VEWA 3ZM2A 2I4HA 2H02A 1W7KA 2I5XA 4YR8B 4CVKA 1Q6MA 3EB1A 3QCCA 1BZHA 1U25A 2AHSA 5AWXA 2RF6A 5BX1A 2CNHA 3SR9A 2XJAA 1RXDA 2F6WA 2CM8A 1NO6A 2P4DA 2VTEA 3QCMA 2OC3A 2GWOA 1U26A 4R0TA 2GP0A 2VOSA 2PBNA 1C88A 3B7OA 4OHLA 3I80A 2UUOA 1C86A
chains in the Genus database with same CATH topology
4KYRA 1YFOA 2I42A 2B3OA 4OHEA 2QDMA 4DGXA 2J17A 2VEUA 3ZMPA 3S3FA 2FJMA 2HNQA 3QCJA 3AWEA 2MBCA 2QEPA 1ZCKA 3I7ZA 1T49A 3AWGA 2CJZA 2I6PA 5K9WA 4PVGA 2WGPA 3QCLA 5BUGA 3S3EA 4Y14A 1J4XA 4YAAA 5KA9A 3QCKA 4BPCA 3CM3A 4ZN5A 3SMEA 3V0DA 1LYVA 1P15A 2NZ6A 1BZCA 4WOHA 2H03A 2H04A 2QBQA 1Q6PA 1YTWA 4GFVA 3O4TA 1I57A 4JMKA 3S4OA 1LQFA 2I3RA 1OETA 2AZRA 5IBSA 1G7FA 2PSZA 5K25A 3MOZA 3MOWA 4ICZA 5KA4A 4JNBA 1YTNA 1T4JA 1EENA 5KADA 1ECVA 3F9AA 1FQ1A 2F71A 3D1QA 3RGOA 2I1YA 4JMJA 2PA5A 4B04A 2BV5A 1XM2A 1NNYA 4MBBA 1PH0A 3RO1A 4RDDA 2BIJA 2CMAA 2ESBA 4S0GA 4QAHA 1NZ7A 3PS5A 1GFYA 5KABA 2CNIA 3F41A 3A5JA 3OLRA 4KI9A 4R0SA 1JLNA 2F6VA 4QUNA 4GRZA 4QAPA 3S3HA 5K9VA 2NTAA 2PT0A 1PTUA 1G4US 1ZC0A 3S3KA 4JBCA 2BGDA 2GJTA 3BM8A 4I8NA 3BRHA 4GE6A 3A5KA 5EHPA 2I6MA 2OZ5A 1WCHA 1EEOA 5HDEA 3OMHA 1NWLA 1Q1MA 1I9TA 2M3VA 2I4GA 2VEYA 5KA8A 1LARA 4Y2EA 4Z6BA 1PXHA 2DXPA 3V0IA 3QCEA 3BLTA 1BZJA 3D9CA 2H4KA 3V0EA 3EU0A 2I6JA 4GFUA 2YDUA 4RI5A 2F70A 1NL9A 2G59A 3QCHA 4BJOA 4GWFA 1YPTA 4KYQA 1RPMA 3MMJA 1WAXA 3O3LA 4OHIA 2BGEA 2I75A 3V0GA 2QDCA 3QCNA 1MKPA 2I6OA 1G4WR 2Q47A 1G7GA 1PA1A 1OEUA 1V3AA 3QCIA 2I4EA 3D42A 3QKPA 3D44A 2NV5A 2ZN7A 2QCJA 3F81A 1PTVA 3N0AA 3EMUA 3O4UA 4D3RA 3O4SA 5K23A 4OHDA 3QCGA 1FPZA 2HCMA 5KA1A 3M4UA 4RH5A 5KA2A 5IBMA 4RI4A 5KA7A 4GRYA 1XBOA 1Q6TA 4ERCA 1KAVA 1D5RA 1C84A 4R30A 4D3PA 3GXHA 2CNEA 2QDPA 2P6XA 2B4PA 1SUGA 5K24A 1L8GA 2R0BA 1R6HA 1VHRA 3GXGA 5K22A 1G1HA 1OEVA 5M43A 1M3GA 1XRIA 4ZI4A 2H4VA 3H2XA 3QKQA 1XXPA 2E0TA 3EZZA 2F46A 5I6VA 1QXKA 4WTYA 1C83A 2CM3A 1NWEA 3ZMQA 1A5YA 4WU3A 3S4EA 1FPRA 1Q6JA 2Q05A 4NYHA 5KACA 2FH7A 4IKCA 1OEMX 2CM7A 2HVLA 3I36A 5KA0A 2IMGA 1G1FA 1XXVA 1OESA 2F6YA 2QBPA 5KAAA 2PI7A 5BZZA 1U24A 3ZV2A 4NNDA 1PYNA 3QCFA 2HC1A 4DGPA 1KAKA 2JJDA 4NWFA 3U96A 2B4SA 2NT7A 4J51A 4NX8A 2HC2A 1ONYA 1YWFA 4RKKA 2F6TA 4ZRTA 2B49A 1YGRA 2A3KA 4RHGA 2G6ZA 2H4GA 3F9BA 4H34A 4AZ1A 5EHRA 2NLKA 2QBSA 1QZ0A 2Y2FA 4HRFA 3V0HA 1PTYA 3RZ2A 2ZMMA 2FJNA 4TVVA 3NMEA 1ZCLA 1Q6NA 4QUMA 3V0FA 2OOQA 1X24A 3QCDA 3F99A 5MMZB 4D3QA 2CNGA 4HJPA 2F6ZA 1WRMA 4QBEA 1YTSA 1JF7A 1PTTA 1OHCA 4GE5A 3D1HA 1C87A 1GWZA 2CMCA 1OEOX 4RH9A 3QCBA 2OUDA 1C85A 1YZ4A 2B4UA 4GS0A 2HB1A 2A8BA 3ZM3A 1ONZA 2VEXA 1L8KA 2QCTA 3LJ8A 4NWGA 1AAXA 4HJQA 2NT2A 2PQ5A 1ZZWA 1YGUA 2C7SA 4H1OA 4GE2A 4PYHA 2Y96A 2B4OA 3V0JA 1I9SA 4WU2A 2I6IA 2J16B 5BZXA 3O5XA 3CWEA 2CM2A 1PA9A 3RGQA 5KA3A 2F6FA 2C46A 2HXPA 3AWFA 2BZLA 2J16A 5LXQB 2CNFA 1OHEA 2I3UA 3ZM1A 3BLUA 2HNPA 2CMBA 2CFVA 3EAXA 4QBWA 2QBRA 4OHHA 2VEVA 3D1OA 5GTJA 1G1GA 1Q6SA 2B07A 3ZM0A 1T48A 1OHDA 2SHPA 1YN9A 5J8RA 2HY3A 2VEWA 3ZM2A 2I4HA 2H02A 2I5XA 4YR8B 1Q6MA 3EB1A 3QCCA 1BZHA 1U25A 2AHSA 5AWXA 2RF6A 5BX1A 2CNHA 3SR9A 1RXDA 2F6WA 2CM8A 1NO6A 2P4DA 3QCMA 2OC3A 2GWOA 1U26A 4R0TA 2GP0A 2PBNA 1C88A 3B7OA 4OHLA 3I80A 1C86A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KYR A;  1YFO A;  2I42 A;  2B3O A;  4OHE A;  2QDM A;  4DGX A;  2J17 A;  2VEU A;  3ZMP A;  3S3F A;  2FJM A;  2HNQ A;  3QCJ A;  3AWE A;  2MBC A;  2QEP A;  1ZCK A;  3I7Z A;  1T49 A;  3AWG A;  2CJZ A;  2I6P A;  5K9W A;  4PVG A;  2WGP A;  3QCL A;  5BUG A;  3S3E A;  4Y14 A;  1J4X A;  4YAA A;  5KA9 A;  3QCK A;  4BPC A;  3CM3 A;  4ZN5 A;  3SME A;  3V0D A;  1LYV A;  1P15 A;  2NZ6 A;  1BZC A;  4WOH A;  2H03 A;  2H04 A;  2QBQ A;  1Q6P A;  1YTW A;  4GFV A;  3O4T A;  1I57 A;  4JMK A;  3S4O A;  1LQF A;  2I3R A;  1OET A;  2AZR A;  5IBS A;  1G7F A;  2PSZ A;  5K25 A;  3MOZ A;  3MOW A;  4ICZ A;  5KA4 A;  4JNB A;  1YTN A;  1T4J A;  1EEN A;  5KAD A;  1ECV A;  3F9A A;  1FQ1 A;  2F71 A;  3D1Q A;  3RGO A;  2I1Y A;  4JMJ A;  2PA5 A;  4B04 A;  2BV5 A;  1XM2 A;  1NNY A;  4MBB A;  1PH0 A;  3RO1 A;  4RDD A;  2BIJ A;  2CMA A;  2ESB A;  4S0G A;  4QAH A;  1NZ7 A;  3PS5 A;  1GFY A;  5KAB A;  2CNI A;  3F41 A;  3A5J A;  3OLR A;  4KI9 A;  4R0S A;  1JLN A;  2F6V A;  4QUN A;  4GRZ A;  4QAP A;  3S3H A;  5K9V A;  2NTA A;  2PT0 A;  1PTU A;  1G4U S;  1ZC0 A;  3S3K A;  4JBC A;  2BGD A;  2GJT A;  3BM8 A;  4I8N A;  3BRH A;  4GE6 A;  3A5K A;  5EHP A;  2I6M A;  2OZ5 A;  1WCH A;  1EEO A;  5HDE A;  3OMH A;  1NWL A;  1Q1M A;  1I9T A;  2M3V A;  2I4G A;  2VEY A;  5KA8 A;  1LAR A;  4Y2E A;  4Z6B A;  1PXH A;  2DXP A;  3V0I A;  3QCE A;  3BLT A;  1BZJ A;  3D9C A;  2H4K A;  3V0E A;  3EU0 A;  2I6J A;  4GFU A;  2YDU A;  4RI5 A;  2F70 A;  1NL9 A;  2G59 A;  3QCH A;  4BJO A;  4GWF A;  1YPT A;  4KYQ A;  1RPM A;  3MMJ A;  1WAX A;  3O3L A;  4OHI A;  2BGE A;  2I75 A;  3V0G A;  2QDC A;  3QCN A;  1MKP A;  2I6O A;  1G4W R;  2Q47 A;  1G7G A;  1PA1 A;  1OEU A;  1V3A A;  3QCI A;  2I4E A;  3D42 A;  3QKP A;  3D44 A;  2NV5 A;  2ZN7 A;  2QCJ A;  3F81 A;  1PTV A;  3N0A A;  3EMU A;  3O4U A;  4D3R A;  3O4S A;  5K23 A;  4OHD A;  3QCG A;  1FPZ A;  2HCM A;  5KA1 A;  3M4U A;  4RH5 A;  5KA2 A;  5IBM A;  4RI4 A;  5KA7 A;  4GRY A;  1XBO A;  1Q6T A;  4ERC A;  1KAV A;  1D5R A;  1C84 A;  4R30 A;  4D3P A;  3GXH A;  2CNE A;  2QDP A;  2P6X A;  2B4P A;  1SUG A;  5K24 A;  1L8G A;  2R0B A;  1R6H A;  1VHR A;  3GXG A;  5K22 A;  1G1H A;  1OEV A;  5M43 A;  1M3G A;  1XRI A;  4ZI4 A;  2H4V A;  3H2X A;  3QKQ A;  1XXP A;  2E0T A;  3EZZ A;  2F46 A;  5I6V A;  1QXK A;  4WTY A;  1C83 A;  2CM3 A;  1NWE A;  3ZMQ A;  1A5Y A;  4WU3 A;  3S4E A;  1FPR A;  1Q6J A;  2Q05 A;  4NYH A;  5KAC A;  2FH7 A;  4IKC A;  1OEM X;  2CM7 A;  2HVL A;  3I36 A;  5KA0 A;  2IMG A;  1G1F A;  1XXV A;  1OES A;  2F6Y A;  2QBP A;  5KAA A;  2PI7 A;  5BZZ A;  1U24 A;  3ZV2 A;  4NND A;  1PYN A;  3QCF A;  2HC1 A;  4DGP A;  1KAK A;  2JJD A;  4NWF A;  3U96 A;  2B4S A;  2NT7 A;  4J51 A;  4NX8 A;  2HC2 A;  1ONY A;  1YWF A;  4RKK A;  2F6T A;  4ZRT A;  2B49 A;  1YGR A;  2A3K A;  4RHG A;  2G6Z A;  2H4G A;  3F9B A;  4H34 A;  4AZ1 A;  5EHR A;  2NLK A;  2QBS A;  1QZ0 A;  2Y2F A;  4HRF A;  3V0H A;  1PTY A;  3RZ2 A;  2ZMM A;  2FJN A;  4TVV A;  3NME A;  1ZCL A;  1Q6N A;  4QUM A;  3V0F A;  2OOQ A;  1X24 A;  3QCD A;  3F99 A;  5MMZ B;  4D3Q A;  2CNG A;  4HJP A;  2F6Z A;  1WRM A;  4QBE A;  1YTS A;  1JF7 A;  1PTT A;  1OHC A;  4GE5 A;  3D1H A;  1C87 A;  1GWZ A;  2CMC A;  1OEO X;  4RH9 A;  3QCB A;  2OUD A;  1C85 A;  1YZ4 A;  2B4U A;  4GS0 A;  2HB1 A;  2A8B A;  3ZM3 A;  1ONZ A;  2VEX A;  1L8K A;  2QCT A;  3LJ8 A;  4NWG A;  1AAX A;  4HJQ A;  2NT2 A;  2PQ5 A;  1ZZW A;  1YGU A;  2C7S A;  4H1O A;  4GE2 A;  4PYH A;  2Y96 A;  2B4O A;  3V0J A;  1I9S A;  4WU2 A;  2I6I A;  2J16 B;  5BZX A;  3O5X A;  3CWE A;  2CM2 A;  1PA9 A;  3RGQ A;  5KA3 A;  2F6F A;  2C46 A;  2HXP A;  3AWF A;  2BZL A;  2J16 A;  5LXQ B;  2CNF A;  1OHE A;  2I3U A;  3ZM1 A;  3BLU A;  2HNP A;  2CMB A;  2CFV A;  3EAX A;  4QBW A;  2QBR A;  4OHH A;  2VEV A;  3D1O A;  5GTJ A;  1G1G A;  1Q6S A;  2B07 A;  3ZM0 A;  1T48 A;  1OHD A;  2SHP A;  1YN9 A;  5J8R A;  2HY3 A;  2VEW A;  3ZM2 A;  2I4H A;  2H02 A;  2I5X A;  4YR8 B;  1Q6M A;  3EB1 A;  3QCC A;  1BZH A;  1U25 A;  2AHS A;  5AWX A;  2RF6 A;  5BX1 A;  2CNH A;  3SR9 A;  1RXD A;  2F6W A;  2CM8 A;  1NO6 A;  2P4D A;  3QCM A;  2OC3 A;  2GWO A;  1U26 A;  4R0T A;  2GP0 A;  2PBN A;  1C88 A;  3B7O A;  4OHL A;  3I80 A;  1C86 A; 
#chains in the Genus database with same CATH topology
 3NRS A;  4KYR A;  1YFO A;  2I42 A;  4BUC A;  2B3O A;  5A5F A;  4OHE A;  2QDM A;  4DGX A;  2J17 A;  2VEU A;  3ZMP A;  3S3F A;  2FJM A;  2HNQ A;  3QCJ A;  4HV4 A;  3AWE A;  2MBC A;  2QEP A;  1ZCK A;  3I7Z A;  1T49 A;  3AWG A;  2CJZ A;  2I6P A;  5K9W A;  4PVG A;  2WGP A;  3QCL A;  5BUG A;  3S3E A;  4Y14 A;  1J4X A;  4YAA A;  5KA9 A;  3QCK A;  4BPC A;  3CM3 A;  4ZN5 A;  3SME A;  3V0D A;  1LYV A;  1P15 A;  2NZ6 A;  1BZC A;  3MVN A;  4WOH A;  2H03 A;  2H04 A;  1O5Z A;  2QBQ A;  1Q6P A;  2WTZ A;  1YTW A;  4GFV A;  3O4T A;  1I57 A;  4JMK A;  3S4O A;  1LQF A;  2I3R A;  1OET A;  2AZR A;  5IBS A;  1G7F A;  2PSZ A;  5K25 A;  3MOZ A;  3MOW A;  4ICZ A;  5KA4 A;  1GQQ A;  4JNB A;  1YTN A;  1T4J A;  1EEN A;  5KAD A;  1ECV A;  3F9A A;  1FQ1 A;  2F71 A;  3D1Q A;  4UAG A;  3RGO A;  2I1Y A;  4JMJ A;  2PA5 A;  4B04 A;  2BV5 A;  1XM2 A;  1NNY A;  4MBB A;  1PH0 A;  3RO1 A;  4RDD A;  2BIJ A;  2CMA A;  2ESB A;  4S0G A;  4QAH A;  1NZ7 A;  3PS5 A;  1GFY A;  5KAB A;  2CNI A;  3F41 A;  3A5J A;  3PYZ A;  4BUB A;  3OLR A;  4KI9 A;  4R0S A;  1JLN A;  2F6V A;  4QUN A;  4GRZ A;  4QAP A;  3S3H A;  5K9V A;  2NTA A;  2PT0 A;  1PTU A;  1G4U S;  1ZC0 A;  3S3K A;  4JBC A;  2VTD A;  2BGD A;  2GJT A;  3BM8 A;  4I8N A;  3BRH A;  4GE6 A;  3A5K A;  5EHP A;  4C13 A;  2I6M A;  2OZ5 A;  1WCH A;  4C12 A;  1EEO A;  5HDE A;  1JBV A;  3OMH A;  1NWL A;  1Q1M A;  1I9T A;  2M3V A;  2JFH A;  2I4G A;  2VEY A;  5KA8 A;  1LAR A;  4Y2E A;  4Z6B A;  1PXH A;  2DXP A;  3V0I A;  3QCE A;  3BLT A;  1BZJ A;  4CVL A;  3D9C A;  2H4K A;  3V0E A;  2UAG A;  3EU0 A;  2AM1 A;  2I6J A;  5A5E A;  4GFU A;  2YDU A;  4RI5 A;  2F70 A;  1NL9 A;  2G59 A;  3UAG A;  3QCH A;  4BJO A;  4GWF A;  1YPT A;  4KYQ A;  1RPM A;  3MMJ A;  1WAX A;  3O3L A;  4OHI A;  2BGE A;  3ZM6 A;  2I75 A;  3V0G A;  2QDC A;  3LK7 A;  3QCN A;  1MKP A;  2I6O A;  1G4W R;  2Q47 A;  1G7G A;  1PA1 A;  1OEU A;  1V3A A;  3QCI A;  2GC6 A;  2Y67 A;  2AM2 A;  2I4E A;  3D42 A;  3QKP A;  3D44 A;  2NV5 A;  2ZN7 A;  2QCJ A;  3F81 A;  2JFG A;  1PTV A;  3N0A A;  3EMU A;  3O4U A;  2GCA A;  4D3R A;  1P31 A;  3O4S A;  5K23 A;  4OHD A;  3QCG A;  1FPZ A;  4QF5 A;  2HCM A;  5KA1 A;  3M4U A;  2F00 A;  4RH5 A;  5KA2 A;  5IBM A;  1P3D A;  4RI4 A;  5KA7 A;  2X5O A;  1E0D A;  2Y66 A;  4GRY A;  1XBO A;  1Q6T A;  4ERC A;  1KAV A;  1D5R A;  1C84 A;  2UUP A;  4R30 A;  4D3P A;  3GXH A;  2CNE A;  2QDP A;  2P6X A;  2B4P A;  1SUG A;  5K24 A;  4CVM A;  1L8G A;  2R0B A;  1R6H A;  1VHR A;  3GXG A;  5K22 A;  1G1H A;  1OEV A;  5M43 A;  1M3G A;  1XRI A;  4ZI4 A;  1W78 A;  2H4V A;  3H2X A;  3QKQ A;  1XXP A;  1GQY A;  2E0T A;  3EZZ A;  2F46 A;  2XPC A;  5I6V A;  1QXK A;  4WTY A;  2GCB A;  1C83 A;  2CM3 A;  1NWE A;  3ZMQ A;  1A5Y A;  4WU3 A;  3S4E A;  1FPR A;  1Q6J A;  2JFF A;  2Q05 A;  4NYH A;  5KAC A;  2FH7 A;  3HN7 A;  4IKC A;  3ZM5 A;  1OEM X;  2CM7 A;  2HVL A;  3I36 A;  5KA0 A;  2IMG A;  1G1F A;  1XXV A;  1OES A;  2F6Y A;  2QBP A;  5KAA A;  2PI7 A;  3N2A A;  5BZZ A;  1U24 A;  3ZV2 A;  4NND A;  1PYN A;  3QCF A;  2HC1 A;  4DGP A;  1KAK A;  2JJD A;  4NWF A;  3U96 A;  2B4S A;  2NT7 A;  4J51 A;  4NX8 A;  2HC2 A;  1ONY A;  1YWF A;  4RKK A;  2F6T A;  1JBW A;  4ZRT A;  2B49 A;  1YGR A;  2A3K A;  4RHG A;  2G6Z A;  2H4G A;  3F9B A;  4H34 A;  4AZ1 A;  3QCZ A;  3ZL8 A;  5EHR A;  2NLK A;  2QBS A;  1QZ0 A;  2Y2F A;  4HRF A;  2VOR A;  3V0H A;  1PTY A;  3RZ2 A;  2ZMM A;  2FJN A;  4TVV A;  3NME A;  1ZCL A;  1Q6N A;  4QUM A;  3V0F A;  2OOQ A;  1X24 A;  3QCD A;  3F99 A;  5MMZ B;  4D3Q A;  2CNG A;  4HJP A;  2F6Z A;  1WRM A;  4QBE A;  1YTS A;  4QDI A;  1JF7 A;  2Y1O A;  1PTT A;  1OHC A;  4GE5 A;  3D1H A;  1C87 A;  1GWZ A;  2CMC A;  1J6U A;  1OEO X;  4RH9 A;  2Y68 A;  3QCB A;  2OUD A;  1C85 A;  1YZ4 A;  2B4U A;  4GS0 A;  2HB1 A;  2A8B A;  3ZM3 A;  1E8C A;  1ONZ A;  2VEX A;  1L8K A;  2QCT A;  3LJ8 A;  4NWG A;  1AAX A;  4HJQ A;  2NT2 A;  2PQ5 A;  1EEH A;  1ZZW A;  1YGU A;  2C7S A;  4H1O A;  2WJP A;  4GE2 A;  4PYH A;  2Y96 A;  2B4O A;  3V0J A;  1I9S A;  4WU2 A;  2I6I A;  2J16 B;  5BZX A;  3O5X A;  3CWE A;  2CM2 A;  1FGS A;  1PA9 A;  3RGQ A;  5KA3 A;  2F6F A;  2C46 A;  2HXP A;  3AWF A;  2BZL A;  2J16 A;  5LXQ B;  2CNF A;  1UAG A;  4ZIY A;  1OHE A;  2I3U A;  3ZM1 A;  1GG4 A;  2GC5 A;  3BLU A;  2HNP A;  2CMB A;  2CFV A;  3EAX A;  4QBW A;  2QBR A;  4OHH A;  2VEV A;  3D1O A;  5GTJ A;  1G1G A;  1Q6S A;  2B07 A;  3ZM0 A;  1T48 A;  1OHD A;  2SHP A;  1YN9 A;  5J8R A;  2HY3 A;  2VEW A;  3ZM2 A;  2I4H A;  2H02 A;  1W7K A;  2I5X A;  4YR8 B;  4CVK A;  1Q6M A;  3EB1 A;  3QCC A;  1BZH A;  1U25 A;  2AHS A;  5AWX A;  2RF6 A;  5BX1 A;  2CNH A;  3SR9 A;  2XJA A;  1RXD A;  2F6W A;  2CM8 A;  1NO6 A;  2P4D A;  2VTE A;  3QCM A;  2OC3 A;  2GWO A;  1U26 A;  4R0T A;  2GP0 A;  2VOS A;  2PBN A;  1C88 A;  3B7O A;  4OHL A;  3I80 A;  2UUO A;  1C86 A; 
#chains in the Genus database with same CATH homology
 4KYR A;  1YFO A;  2I42 A;  2B3O A;  4OHE A;  2QDM A;  4DGX A;  2J17 A;  2VEU A;  3ZMP A;  3S3F A;  2FJM A;  2HNQ A;  3QCJ A;  3AWE A;  2MBC A;  2QEP A;  1ZCK A;  3I7Z A;  1T49 A;  3AWG A;  2CJZ A;  2I6P A;  5K9W A;  4PVG A;  2WGP A;  3QCL A;  5BUG A;  3S3E A;  4Y14 A;  1J4X A;  4YAA A;  5KA9 A;  3QCK A;  4BPC A;  3CM3 A;  4ZN5 A;  3SME A;  3V0D A;  1LYV A;  1P15 A;  2NZ6 A;  1BZC A;  4WOH A;  2H03 A;  2H04 A;  2QBQ A;  1Q6P A;  1YTW A;  4GFV A;  3O4T A;  1I57 A;  4JMK A;  3S4O A;  1LQF A;  2I3R A;  1OET A;  2AZR A;  5IBS A;  1G7F A;  2PSZ A;  5K25 A;  3MOZ A;  3MOW A;  4ICZ A;  5KA4 A;  4JNB A;  1YTN A;  1T4J A;  1EEN A;  5KAD A;  1ECV A;  3F9A A;  1FQ1 A;  2F71 A;  3D1Q A;  3RGO A;  2I1Y A;  4JMJ A;  2PA5 A;  4B04 A;  2BV5 A;  1XM2 A;  1NNY A;  4MBB A;  1PH0 A;  3RO1 A;  4RDD A;  2BIJ A;  2CMA A;  2ESB A;  4S0G A;  4QAH A;  1NZ7 A;  3PS5 A;  1GFY A;  5KAB A;  2CNI A;  3F41 A;  3A5J A;  3OLR A;  4KI9 A;  4R0S A;  1JLN A;  2F6V A;  4QUN A;  4GRZ A;  4QAP A;  3S3H A;  5K9V A;  2NTA A;  2PT0 A;  1PTU A;  1G4U S;  1ZC0 A;  3S3K A;  4JBC A;  2BGD A;  2GJT A;  3BM8 A;  4I8N A;  3BRH A;  4GE6 A;  3A5K A;  5EHP A;  2I6M A;  2OZ5 A;  1WCH A;  1EEO A;  5HDE A;  3OMH A;  1NWL A;  1Q1M A;  1I9T A;  2M3V A;  2I4G A;  2VEY A;  5KA8 A;  1LAR A;  4Y2E A;  4Z6B A;  1PXH A;  2DXP A;  3V0I A;  3QCE A;  3BLT A;  1BZJ A;  3D9C A;  2H4K A;  3V0E A;  3EU0 A;  2I6J A;  4GFU A;  2YDU A;  4RI5 A;  2F70 A;  1NL9 A;  2G59 A;  3QCH A;  4BJO A;  4GWF A;  1YPT A;  4KYQ A;  1RPM A;  3MMJ A;  1WAX A;  3O3L A;  4OHI A;  2BGE A;  2I75 A;  3V0G A;  2QDC A;  3QCN A;  1MKP A;  2I6O A;  1G4W R;  2Q47 A;  1G7G A;  1PA1 A;  1OEU A;  1V3A A;  3QCI A;  2I4E A;  3D42 A;  3QKP A;  3D44 A;  2NV5 A;  2ZN7 A;  2QCJ A;  3F81 A;  1PTV A;  3N0A A;  3EMU A;  3O4U A;  4D3R A;  3O4S A;  5K23 A;  4OHD A;  3QCG A;  1FPZ A;  2HCM A;  5KA1 A;  3M4U A;  4RH5 A;  5KA2 A;  5IBM A;  4RI4 A;  5KA7 A;  4GRY A;  1XBO A;  1Q6T A;  4ERC A;  1KAV A;  1D5R A;  1C84 A;  4R30 A;  4D3P A;  3GXH A;  2CNE A;  2QDP A;  2P6X A;  2B4P A;  1SUG A;  5K24 A;  1L8G A;  2R0B A;  1R6H A;  1VHR A;  3GXG A;  5K22 A;  1G1H A;  1OEV A;  5M43 A;  1M3G A;  1XRI A;  4ZI4 A;  2H4V A;  3H2X A;  3QKQ A;  1XXP A;  2E0T A;  3EZZ A;  2F46 A;  5I6V A;  1QXK A;  4WTY A;  1C83 A;  2CM3 A;  1NWE A;  3ZMQ A;  1A5Y A;  4WU3 A;  3S4E A;  1FPR A;  1Q6J A;  2Q05 A;  4NYH A;  5KAC A;  2FH7 A;  4IKC A;  1OEM X;  2CM7 A;  2HVL A;  3I36 A;  5KA0 A;  2IMG A;  1G1F A;  1XXV A;  1OES A;  2F6Y A;  2QBP A;  5KAA A;  2PI7 A;  5BZZ A;  1U24 A;  3ZV2 A;  4NND A;  1PYN A;  3QCF A;  2HC1 A;  4DGP A;  1KAK A;  2JJD A;  4NWF A;  3U96 A;  2B4S A;  2NT7 A;  4J51 A;  4NX8 A;  2HC2 A;  1ONY A;  1YWF A;  4RKK A;  2F6T A;  4ZRT A;  2B49 A;  1YGR A;  2A3K A;  4RHG A;  2G6Z A;  2H4G A;  3F9B A;  4H34 A;  4AZ1 A;  5EHR A;  2NLK A;  2QBS A;  1QZ0 A;  2Y2F A;  4HRF A;  3V0H A;  1PTY A;  3RZ2 A;  2ZMM A;  2FJN A;  4TVV A;  3NME A;  1ZCL A;  1Q6N A;  4QUM A;  3V0F A;  2OOQ A;  1X24 A;  3QCD A;  3F99 A;  5MMZ B;  4D3Q A;  2CNG A;  4HJP A;  2F6Z A;  1WRM A;  4QBE A;  1YTS A;  1JF7 A;  1PTT A;  1OHC A;  4GE5 A;  3D1H A;  1C87 A;  1GWZ A;  2CMC A;  1OEO X;  4RH9 A;  3QCB A;  2OUD A;  1C85 A;  1YZ4 A;  2B4U A;  4GS0 A;  2HB1 A;  2A8B A;  3ZM3 A;  1ONZ A;  2VEX A;  1L8K A;  2QCT A;  3LJ8 A;  4NWG A;  1AAX A;  4HJQ A;  2NT2 A;  2PQ5 A;  1ZZW A;  1YGU A;  2C7S A;  4H1O A;  4GE2 A;  4PYH A;  2Y96 A;  2B4O A;  3V0J A;  1I9S A;  4WU2 A;  2I6I A;  2J16 B;  5BZX A;  3O5X A;  3CWE A;  2CM2 A;  1PA9 A;  3RGQ A;  5KA3 A;  2F6F A;  2C46 A;  2HXP A;  3AWF A;  2BZL A;  2J16 A;  5LXQ B;  2CNF A;  1OHE A;  2I3U A;  3ZM1 A;  3BLU A;  2HNP A;  2CMB A;  2CFV A;  3EAX A;  4QBW A;  2QBR A;  4OHH A;  2VEV A;  3D1O A;  5GTJ A;  1G1G A;  1Q6S A;  2B07 A;  3ZM0 A;  1T48 A;  1OHD A;  2SHP A;  1YN9 A;  5J8R A;  2HY3 A;  2VEW A;  3ZM2 A;  2I4H A;  2H02 A;  2I5X A;  4YR8 B;  1Q6M A;  3EB1 A;  3QCC A;  1BZH A;  1U25 A;  2AHS A;  5AWX A;  2RF6 A;  5BX1 A;  2CNH A;  3SR9 A;  1RXD A;  2F6W A;  2CM8 A;  1NO6 A;  2P4D A;  3QCM A;  2OC3 A;  2GWO A;  1U26 A;  4R0T A;  2GP0 A;  2PBN A;  1C88 A;  3B7O A;  4OHL A;  3I80 A;  1C86 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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