2B07A

Crystal structure of ptp1b with tricyclic thiophene inhibitor.
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
297
structure length
297
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Tyrosine-protein phosphatase, non-receptor type 1
total genus 110
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2005-09-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2b07A00
4RI5A 2CM2A 4GRYA 3S4OA 2BIJA 4R0TA 3QKQA 2AHSA 2CMCA 4QBEA 2GJTA 2I1YA 2J17A 2P6XA 1Q6TA 1P15A 5KA1A 1YGRA 2CM3A 4H1OA 1PYNA 2QBQA 2I6OA 4WOHA 4KYQA 5KA0A 4GWFA 1T48A 1OEMX 3EU0A 2GP0A 3S4EA 3S3KA 2B07A 1G7FA 5BZXA 2H02A 2C46A 2RF6A 5KACA 3QCFA 2BZLA 2PSZA 3F99A 2H03A 3F9AA 5I6VA 2CNHA 3U96A 3H2XA 1JF7A 1T4JA 1WAXA 2NV5A 3M4UA 5GTJA 3QCKA 3AWGA 1YPTA 4WU2A 5M43A 2SHPA 3D9CA 4NYHA 2H4VA 5BX1A 1C85A 2QCJA 2M3VA 3N0AA 2QDPA 2CMAA 2ZMMA 1BZCA 1C87A 2I4GA 2HC2A 3QCIA 2QBRA 1NO6A 1YTSA 3V0FA 1PA9A 2F6VA 4MBBA 3A5JA 1OHCA 1PTYA 5KA2A 3F9BA 4NWGA 1KAKA 1PH0A 3A5KA 3ZM2A 1Q6JA 2CFVA 2PA5A 3ZMQA 1PA1A 2HC1A 4QUMA 1ECVA 1KAVA 2H4GA 5EHPA 3RO1A 1XBOA 5K9WA 3EB1A 2A3KA 1I57A 1J4XA 1G1FA 2NT2A 4QAHA 4NNDA 3QCGA 4WU3A 4DGXA 2NLKA 2I4HA 4GFUA 2ZN7A 2E0TA 1T49A 4GRZA 4AZ1A 2CMBA 1U26A 5K9VA 1I9TA 1X24A 1XXVA 4QAPA 1D5RA 2I4EA 1YFOA 4RH9A 5K25A 1XM2A 2ESBA 2CNIA 1ZCLA 2CNFA 1PTTA 4GS0A 3O4SA 4ICZA 2QDMA 3D44A 2HNQA 3QCDA 3D42A 3RGOA 3F41A 5IBSA 1QXKA 1ZC0A 4B04A 3GXHA 1YTWA 2JJDA 4Y14A 1BZHA 1L8KA 1PTUA 2Y2FA 1NNYA 1PXHA 2G59A 1ZCKA 3BM8A 1RXDA 1NL9A 3BLUA 4QUNA 2IMGA 2I5XA 4OHIA 1M3GA 4RKKA 4IKCA 2PT0A 2I6MA 3V0JA 4RI4A 4GE2A 4GE6A 4PVGA 5K23A 2DXPA 2VEVA 1Q6NA 1EENA 3BRHA 3PS5A 2YDUA 4JMKA 2NZ6A 3O4TA 2I6PA 4RDDA 3QCBA 5K24A 1FPRA 1OEOX 2BV5A 2OZ5A 2FJNA 1YN9A 2H4KA 4BPCA 1U24A 1NZ7A 2G6ZA 2OC3A 4RH5A 5BUGA 2PI7A 2VEXA 1FPZA 3QKPA 5KA4A 4GFVA 3V0IA 3QCJA 1C84A 2F70A 1VHRA 5KA7A 3D1QA 5KAAA 5IBMA 3OMHA 4HJPA 4HJQA 2F6TA 1GWZA 2FH7A 2I6IA 4HRFA 3SR9A 3ZM0A 1WCHA 2B4PA 3MMJA 4JNBA 4I8NA 3LJ8A 4QBWA 4ZI4A 3ZM3A 1MKPA 2PQ5A 3D1OA 3MOWA 2B4UA 1I9SA 3RZ2A 5LXQB 2HXPA 5J8RA 1YGUA 2HY3A 3GXGA 3I36A 2J16B 3AWEA 3QCNA 1WRMA 2I42A 3AWFA 1OEUA 4H34A 2HVLA 2F46A 5KA8A 3CM3A 2I6JA 1G4WR 2PBNA 4OHDA 1AAXA 1NWEA 4Z6BA 2I75A 5KA3A 2B49A 2R0BA 2CM7A 5EHRA 1OESA 2F71A 1L8GA 3B7OA 4ZRTA 2HCMA 3QCLA 1U25A 1V3AA 3BLTA 1YZ4A 2WGPA 5AWXA 5KADA 1BZJA 1OHEA 4ERCA 1ONZA 1Q6SA 4YAAA 1A5YA 1Q1MA 4KYRA 3V0EA 4JMJA 5HDEA 4JBCA 3ZV2A 3OLRA 3CWEA 3ZM1A 2CNEA 2I3RA 3MOZA 2NT7A 2H04A 4YR8B 4D3RA 4NWFA 2QBSA 3I7ZA 1RPMA 4OHEA 1QZ0A 1YWFA 3I80A 4OHLA 1LYVA 1C86A 3SMEA 4GE5A 3O4UA 1OEVA 4NX8A 1EEOA 1JLNA 1C83A 4R0SA 3QCEA 2I3UA 5K22A 3O5XA 3EMUA 2P4DA 2VEYA 5MMZB 2F6FA 1G1GA 3QCMA 2Y96A 4D3QA 2QCTA 1SUGA 1ONYA 3RGQA 5KA9A 2C7SA 2NTAA 1C88A 2CM8A 2QDCA 1GFYA 1Q6MA 3O3LA 4OHHA 3V0HA 3S3EA 4PYHA 2Q47A 2MBCA 1Q6PA 2QBPA 3F81A 2A8BA 4J51A 3S3HA 1G7GA 3S3FA 4BJOA 4DGPA 1ZZWA 3ZMPA 2F6ZA 1NWLA 2OOQA 2AZRA 1LARA 1G4US 2BGDA 3QCCA 4TVVA 2F6YA 2J16A 2OUDA 4R30A 2FJMA 1LQFA 2B3OA 3EAXA 2BGEA 4RHGA 2B4OA 3V0GA 4KI9A 2HNPA 2CNGA 1R6HA 2VEUA 2HB1A 1OETA 2Q05A 3QCHA 1XRIA 1OHDA 2VEWA 4S0GA 1FQ1A 3D1HA 2GWOA 1YTNA 5BZZA 4Y2EA 3NMEA 2CJZA 1XXPA 3V0DA 2QEPA 4D3PA 1PTVA 2F6WA 5KABA 1G1HA 3EZZA 4WTYA 4ZN5A 2B4SA
chains in the Genus database with same CATH superfamily
4RI5A 2CM2A 4GRYA 3S4OA 2BIJA 4R0TA 3QKQA 2AHSA 2CMCA 2F00A 2GJTA 4QBEA 2I1YA 2J17A 2P6XA 1Q6TA 1P15A 5KA1A 1YGRA 2JFHA 2CM3A 4H1OA 4BUCA 1PYNA 2XJAA 2QBQA 2I6OA 4WOHA 4KYQA 5KA0A 4GWFA 1T48A 2GCBA 1OEMX 3EU0A 2GP0A 3S4EA 3S3KA 2B07A 1G7FA 5BZXA 2VOSA 2H02A 2C46A 2RF6A 1W7KA 5KACA 3QCFA 2BZLA 2PSZA 3F99A 2H03A 3F9AA 5I6VA 2CNHA 3U96A 1GG4A 3H2XA 1JF7A 1T4JA 3ZL8A 1WAXA 1P31A 2NV5A 3M4UA 3N2AA 5GTJA 3QCKA 3AWGA 1YPTA 1EEHA 4WU2A 5M43A 2SHPA 3D9CA 4NYHA 2H4VA 5BX1A 1C85A 2QCJA 2M3VA 3N0AA 2QDPA 2CMAA 2ZMMA 3LK7A 1BZCA 1C87A 2I4GA 2HC2A 3QCIA 2QBRA 1NO6A 1YTSA 3V0FA 1PA9A 2F6VA 2VTDA 4MBBA 3A5JA 1OHCA 1PTYA 5KA2A 3F9BA 4NWGA 1KAKA 1PH0A 3A5KA 3ZM2A 1Q6JA 2CFVA 4C13A 2PA5A 3ZMQA 1PA1A 2HC1A 4QUMA 1ECVA 1KAVA 2H4GA 5EHPA 3RO1A 1XBOA 5K9WA 3EB1A 2A3KA 1I57A 1J4XA 1G1FA 2NT2A 4QAHA 4NNDA 2UAGA 3QCGA 2Y1OA 4WU3A 4DGXA 2NLKA 2I4HA 4GFUA 1FGSA 2ZN7A 2E0TA 4C12A 1T49A 4GRZA 4AZ1A 2GC5A 2CMBA 1U26A 5K9VA 1I9TA 1X24A 1P3DA 1XXVA 1JBVA 4QAPA 1D5RA 2I4EA 2Y67A 1UAGA 2XPCA 1YFOA 4RH9A 5K25A 4CVLA 1J6UA 1XM2A 2ESBA 2CNIA 1ZCLA 2CNFA 1PTTA 4GS0A 3O4SA 4ICZA 2QDMA 3D44A 2HNQA 3QCDA 3D42A 3RGOA 3F41A 5IBSA 1O5ZA 1QXKA 1ZC0A 4B04A 3GXHA 4BUBA 1YTWA 2JJDA 4Y14A 1BZHA 1L8KA 1PTUA 4HV4A 2Y2FA 1NNYA 1PXHA 1E8CA 2G59A 1ZCKA 3BM8A 1RXDA 1NL9A 3BLUA 2UUPA 4QUNA 2IMGA 2I5XA 4OHIA 1M3GA 4RKKA 4IKCA 2PT0A 2I6MA 3QCZA 3V0JA 4RI4A 4GE2A 4GE6A 4PVGA 5K23A 2DXPA 2VEVA 1EENA 1Q6NA 3BRHA 3PS5A 2YDUA 4JMKA 2NZ6A 3O4TA 2I6PA 4RDDA 3QCBA 5K24A 1FPRA 1OEOX 2BV5A 3NRSA 2OZ5A 2FJNA 1YN9A 4UAGA 2H4KA 4BPCA 1U24A 1NZ7A 2G6ZA 2OC3A 2AM1A 4RH5A 5BUGA 2PI7A 2VEXA 1FPZA 3QKPA 5KA4A 4GFVA 3V0IA 3QCJA 1C84A 2F70A 1VHRA 5A5FA 5KA7A 3D1QA 5KAAA 5IBMA 3OMHA 4HJPA 4HJQA 2F6TA 1GWZA 2FH7A 2I6IA 4HRFA 3SR9A 3ZM0A 1WCHA 2B4PA 3MMJA 4JNBA 4I8NA 3LJ8A 4QBWA 4ZI4A 3ZM3A 1MKPA 2PQ5A 3D1OA 3MOWA 2B4UA 1I9SA 3RZ2A 5LXQB 2AM2A 2HXPA 5J8RA 1YGUA 2HY3A 3GXGA 2GC6A 3I36A 2J16B 3AWEA 3QCNA 1WRMA 2I42A 3AWFA 1OEUA 4H34A 2HVLA 2F46A 5KA8A 3CM3A 2I6JA 1G4WR 2PBNA 4OHDA 1AAXA 1NWEA 4Z6BA 2I75A 5KA3A 2B49A 2R0BA 2CM7A 5EHRA 1OESA 2F71A 2VTEA 1L8GA 3B7OA 4ZRTA 2HCMA 3QCLA 1U25A 1V3AA 3BLTA 1YZ4A 2WGPA 5AWXA 2JFFA 5KADA 1BZJA 1OHEA 4ERCA 1ONZA 1Q6SA 4YAAA 1A5YA 1Q1MA 4KYRA 3V0EA 4JMJA 5HDEA 2WJPA 4JBCA 3ZV2A 3OLRA 1GQYA 3CWEA 3ZM1A 2CNEA 2I3RA 3MOZA 2NT7A 2VORA 5A5EA 2H04A 4YR8B 4D3RA 4NWFA 2QBSA 3I7ZA 1RPMA 4OHEA 3ZM6A 1QZ0A 1YWFA 3I80A 4OHLA 1LYVA 1C86A 3SMEA 2JFGA 4GE5A 3O4UA 1OEVA 4NX8A 1JBWA 3ZM5A 2X5OA 2Y66A 1EEOA 1JLNA 1C83A 4R0SA 4QF5A 3QCEA 2I3UA 5K22A 1W78A 3O5XA 4CVMA 3EMUA 2P4DA 2VEYA 5MMZB 2F6FA 1G1GA 2Y68A 3QCMA 2Y96A 4D3QA 2QCTA 1SUGA 1ONYA 3MVNA 3RGQA 5KA9A 2C7SA 1GQQA 4ZIYA 2NTAA 1C88A 2CM8A 2QDCA 1GFYA 1Q6MA 3O3LA 4OHHA 3V0HA 3S3EA 4PYHA 2Q47A 2MBCA 1Q6PA 2QBPA 3F81A 4CVKA 2A8BA 3UAGA 4J51A 3S3HA 1G7GA 3S3FA 4BJOA 4DGPA 1ZZWA 3HN7A 3ZMPA 2F6ZA 1E0DA 1NWLA 2OOQA 2AZRA 1LARA 1G4US 2BGDA 3QCCA 4TVVA 2F6YA 2J16A 2OUDA 4R30A 2FJMA 1LQFA 3EAXA 2B3OA 2WTZA 2BGEA 4RHGA 2B4OA 4QDIA 3V0GA 4KI9A 2HNPA 2CNGA 2GCAA 1R6HA 2UUOA 2VEUA 2HB1A 3PYZA 1OETA 2Q05A 3QCHA 1XRIA 1OHDA 2VEWA 4S0GA 1FQ1A 3D1HA 2GWOA 1YTNA 5BZZA 4Y2EA 3NMEA 2CJZA 1XXPA 3V0DA 2QEPA 4D3PA 1PTVA 2F6WA 5KABA 1G1HA 3EZZA 4WTYA 4ZN5A 2B4SA
chains in the Genus database with same CATH topology
4RI5A 2CM2A 4GRYA 3S4OA 2BIJA 4R0TA 3QKQA 2AHSA 2CMCA 4QBEA 2GJTA 2I1YA 2J17A 2P6XA 1Q6TA 1P15A 5KA1A 1YGRA 2CM3A 4H1OA 1PYNA 2QBQA 2I6OA 4WOHA 4KYQA 5KA0A 4GWFA 1T48A 1OEMX 3EU0A 2GP0A 3S4EA 3S3KA 2B07A 1G7FA 5BZXA 2H02A 2C46A 2RF6A 5KACA 3QCFA 2BZLA 2PSZA 3F99A 2H03A 3F9AA 5I6VA 2CNHA 3U96A 3H2XA 1JF7A 1T4JA 1WAXA 2NV5A 3M4UA 5GTJA 3QCKA 3AWGA 1YPTA 4WU2A 5M43A 2SHPA 3D9CA 4NYHA 2H4VA 5BX1A 1C85A 2QCJA 2M3VA 3N0AA 2QDPA 2CMAA 2ZMMA 1BZCA 1C87A 2I4GA 2HC2A 3QCIA 2QBRA 1NO6A 1YTSA 3V0FA 1PA9A 2F6VA 4MBBA 3A5JA 1OHCA 1PTYA 5KA2A 3F9BA 4NWGA 1KAKA 1PH0A 3A5KA 3ZM2A 1Q6JA 2CFVA 2PA5A 3ZMQA 1PA1A 2HC1A 4QUMA 1ECVA 1KAVA 2H4GA 5EHPA 3RO1A 1XBOA 5K9WA 3EB1A 2A3KA 1I57A 1J4XA 1G1FA 2NT2A 4QAHA 4NNDA 3QCGA 4WU3A 4DGXA 2NLKA 2I4HA 4GFUA 2ZN7A 2E0TA 1T49A 4GRZA 4AZ1A 2CMBA 1U26A 5K9VA 1I9TA 1X24A 1XXVA 4QAPA 1D5RA 2I4EA 1YFOA 4RH9A 5K25A 1XM2A 2ESBA 2CNIA 1ZCLA 2CNFA 1PTTA 4GS0A 3O4SA 4ICZA 2QDMA 3D44A 2HNQA 3QCDA 3D42A 3RGOA 3F41A 5IBSA 1QXKA 1ZC0A 4B04A 3GXHA 1YTWA 2JJDA 4Y14A 1BZHA 1L8KA 1PTUA 2Y2FA 1NNYA 1PXHA 2G59A 1ZCKA 3BM8A 1RXDA 1NL9A 3BLUA 4QUNA 2IMGA 2I5XA 4OHIA 1M3GA 4RKKA 4IKCA 2PT0A 2I6MA 3V0JA 4RI4A 4GE2A 4GE6A 4PVGA 5K23A 2DXPA 2VEVA 1Q6NA 1EENA 3BRHA 3PS5A 2YDUA 4JMKA 2NZ6A 3O4TA 2I6PA 4RDDA 3QCBA 5K24A 1FPRA 1OEOX 2BV5A 2OZ5A 2FJNA 1YN9A 2H4KA 4BPCA 1U24A 1NZ7A 2G6ZA 2OC3A 4RH5A 5BUGA 2PI7A 2VEXA 1FPZA 3QKPA 5KA4A 4GFVA 3V0IA 3QCJA 1C84A 2F70A 1VHRA 5KA7A 3D1QA 5KAAA 5IBMA 3OMHA 4HJPA 4HJQA 2F6TA 1GWZA 2FH7A 2I6IA 4HRFA 3SR9A 3ZM0A 1WCHA 2B4PA 3MMJA 4JNBA 4I8NA 3LJ8A 4QBWA 4ZI4A 3ZM3A 1MKPA 2PQ5A 3D1OA 3MOWA 2B4UA 1I9SA 3RZ2A 5LXQB 2HXPA 5J8RA 1YGUA 2HY3A 3GXGA 3I36A 2J16B 3AWEA 3QCNA 1WRMA 2I42A 3AWFA 1OEUA 4H34A 2HVLA 2F46A 5KA8A 3CM3A 2I6JA 1G4WR 2PBNA 4OHDA 1AAXA 1NWEA 4Z6BA 2I75A 5KA3A 2B49A 2R0BA 2CM7A 5EHRA 1OESA 2F71A 1L8GA 3B7OA 4ZRTA 2HCMA 3QCLA 1U25A 1V3AA 3BLTA 1YZ4A 2WGPA 5AWXA 5KADA 1BZJA 1OHEA 4ERCA 1ONZA 1Q6SA 4YAAA 1A5YA 1Q1MA 4KYRA 3V0EA 4JMJA 5HDEA 4JBCA 3ZV2A 3OLRA 3CWEA 3ZM1A 2CNEA 2I3RA 3MOZA 2NT7A 2H04A 4YR8B 4D3RA 4NWFA 2QBSA 3I7ZA 1RPMA 4OHEA 1QZ0A 1YWFA 3I80A 4OHLA 1LYVA 1C86A 3SMEA 4GE5A 3O4UA 1OEVA 4NX8A 1EEOA 1JLNA 1C83A 4R0SA 3QCEA 2I3UA 5K22A 3O5XA 3EMUA 2P4DA 2VEYA 5MMZB 2F6FA 1G1GA 3QCMA 2Y96A 4D3QA 2QCTA 1SUGA 1ONYA 3RGQA 5KA9A 2C7SA 2NTAA 1C88A 2CM8A 2QDCA 1GFYA 1Q6MA 3O3LA 4OHHA 3V0HA 3S3EA 4PYHA 2Q47A 2MBCA 1Q6PA 2QBPA 3F81A 2A8BA 4J51A 3S3HA 1G7GA 3S3FA 4BJOA 4DGPA 1ZZWA 3ZMPA 2F6ZA 1NWLA 2OOQA 2AZRA 1LARA 1G4US 2BGDA 3QCCA 4TVVA 2F6YA 2J16A 2OUDA 4R30A 2FJMA 1LQFA 2B3OA 3EAXA 2BGEA 4RHGA 2B4OA 3V0GA 4KI9A 2HNPA 2CNGA 1R6HA 2VEUA 2HB1A 1OETA 2Q05A 3QCHA 1XRIA 1OHDA 2VEWA 4S0GA 1FQ1A 3D1HA 2GWOA 1YTNA 5BZZA 4Y2EA 3NMEA 2CJZA 1XXPA 3V0DA 2QEPA 4D3PA 1PTVA 2F6WA 5KABA 1G1HA 3EZZA 4WTYA 4ZN5A 2B4SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RI5 A;  2CM2 A;  4GRY A;  3S4O A;  2BIJ A;  4R0T A;  3QKQ A;  2AHS A;  2CMC A;  4QBE A;  2GJT A;  2I1Y A;  2J17 A;  2P6X A;  1Q6T A;  1P15 A;  5KA1 A;  1YGR A;  2CM3 A;  4H1O A;  1PYN A;  2QBQ A;  2I6O A;  4WOH A;  4KYQ A;  5KA0 A;  4GWF A;  1T48 A;  1OEM X;  3EU0 A;  2GP0 A;  3S4E A;  3S3K A;  2B07 A;  1G7F A;  5BZX A;  2H02 A;  2C46 A;  2RF6 A;  5KAC A;  3QCF A;  2BZL A;  2PSZ A;  3F99 A;  2H03 A;  3F9A A;  5I6V A;  2CNH A;  3U96 A;  3H2X A;  1JF7 A;  1T4J A;  1WAX A;  2NV5 A;  3M4U A;  5GTJ A;  3QCK A;  3AWG A;  1YPT A;  4WU2 A;  5M43 A;  2SHP A;  3D9C A;  4NYH A;  2H4V A;  5BX1 A;  1C85 A;  2QCJ A;  2M3V A;  3N0A A;  2QDP A;  2CMA A;  2ZMM A;  1BZC A;  1C87 A;  2I4G A;  2HC2 A;  3QCI A;  2QBR A;  1NO6 A;  1YTS A;  3V0F A;  1PA9 A;  2F6V A;  4MBB A;  3A5J A;  1OHC A;  1PTY A;  5KA2 A;  3F9B A;  4NWG A;  1KAK A;  1PH0 A;  3A5K A;  3ZM2 A;  1Q6J A;  2CFV A;  2PA5 A;  3ZMQ A;  1PA1 A;  2HC1 A;  4QUM A;  1ECV A;  1KAV A;  2H4G A;  5EHP A;  3RO1 A;  1XBO A;  5K9W A;  3EB1 A;  2A3K A;  1I57 A;  1J4X A;  1G1F A;  2NT2 A;  4QAH A;  4NND A;  3QCG A;  4WU3 A;  4DGX A;  2NLK A;  2I4H A;  4GFU A;  2ZN7 A;  2E0T A;  1T49 A;  4GRZ A;  4AZ1 A;  2CMB A;  1U26 A;  5K9V A;  1I9T A;  1X24 A;  1XXV A;  4QAP A;  1D5R A;  2I4E A;  1YFO A;  4RH9 A;  5K25 A;  1XM2 A;  2ESB A;  2CNI A;  1ZCL A;  2CNF A;  1PTT A;  4GS0 A;  3O4S A;  4ICZ A;  2QDM A;  3D44 A;  2HNQ A;  3QCD A;  3D42 A;  3RGO A;  3F41 A;  5IBS A;  1QXK A;  1ZC0 A;  4B04 A;  3GXH A;  1YTW A;  2JJD A;  4Y14 A;  1BZH A;  1L8K A;  1PTU A;  2Y2F A;  1NNY A;  1PXH A;  2G59 A;  1ZCK A;  3BM8 A;  1RXD A;  1NL9 A;  3BLU A;  4QUN A;  2IMG A;  2I5X A;  4OHI A;  1M3G A;  4RKK A;  4IKC A;  2PT0 A;  2I6M A;  3V0J A;  4RI4 A;  4GE2 A;  4GE6 A;  4PVG A;  5K23 A;  2DXP A;  2VEV A;  1Q6N A;  1EEN A;  3BRH A;  3PS5 A;  2YDU A;  4JMK A;  2NZ6 A;  3O4T A;  2I6P A;  4RDD A;  3QCB A;  5K24 A;  1FPR A;  1OEO X;  2BV5 A;  2OZ5 A;  2FJN A;  1YN9 A;  2H4K A;  4BPC A;  1U24 A;  1NZ7 A;  2G6Z A;  2OC3 A;  4RH5 A;  5BUG A;  2PI7 A;  2VEX A;  1FPZ A;  3QKP A;  5KA4 A;  4GFV A;  3V0I A;  3QCJ A;  1C84 A;  2F70 A;  1VHR A;  5KA7 A;  3D1Q A;  5KAA A;  5IBM A;  3OMH A;  4HJP A;  4HJQ A;  2F6T A;  1GWZ A;  2FH7 A;  2I6I A;  4HRF A;  3SR9 A;  3ZM0 A;  1WCH A;  2B4P A;  3MMJ A;  4JNB A;  4I8N A;  3LJ8 A;  4QBW A;  4ZI4 A;  3ZM3 A;  1MKP A;  2PQ5 A;  3D1O A;  3MOW A;  2B4U A;  1I9S A;  3RZ2 A;  5LXQ B;  2HXP A;  5J8R A;  1YGU A;  2HY3 A;  3GXG A;  3I36 A;  2J16 B;  3AWE A;  3QCN A;  1WRM A;  2I42 A;  3AWF A;  1OEU A;  4H34 A;  2HVL A;  2F46 A;  5KA8 A;  3CM3 A;  2I6J A;  1G4W R;  2PBN A;  4OHD A;  1AAX A;  1NWE A;  4Z6B A;  2I75 A;  5KA3 A;  2B49 A;  2R0B A;  2CM7 A;  5EHR A;  1OES A;  2F71 A;  1L8G A;  3B7O A;  4ZRT A;  2HCM A;  3QCL A;  1U25 A;  1V3A A;  3BLT A;  1YZ4 A;  2WGP A;  5AWX A;  5KAD A;  1BZJ A;  1OHE A;  4ERC A;  1ONZ A;  1Q6S A;  4YAA A;  1A5Y A;  1Q1M A;  4KYR A;  3V0E A;  4JMJ A;  5HDE A;  4JBC A;  3ZV2 A;  3OLR A;  3CWE A;  3ZM1 A;  2CNE A;  2I3R A;  3MOZ A;  2NT7 A;  2H04 A;  4YR8 B;  4D3R A;  4NWF A;  2QBS A;  3I7Z A;  1RPM A;  4OHE A;  1QZ0 A;  1YWF A;  3I80 A;  4OHL A;  1LYV A;  1C86 A;  3SME A;  4GE5 A;  3O4U A;  1OEV A;  4NX8 A;  1EEO A;  1JLN A;  1C83 A;  4R0S A;  3QCE A;  2I3U A;  5K22 A;  3O5X A;  3EMU A;  2P4D A;  2VEY A;  5MMZ B;  2F6F A;  1G1G A;  3QCM A;  2Y96 A;  4D3Q A;  2QCT A;  1SUG A;  1ONY A;  3RGQ A;  5KA9 A;  2C7S A;  2NTA A;  1C88 A;  2CM8 A;  2QDC A;  1GFY A;  1Q6M A;  3O3L A;  4OHH A;  3V0H A;  3S3E A;  4PYH A;  2Q47 A;  2MBC A;  1Q6P A;  2QBP A;  3F81 A;  2A8B A;  4J51 A;  3S3H A;  1G7G A;  3S3F A;  4BJO A;  4DGP A;  1ZZW A;  3ZMP A;  2F6Z A;  1NWL A;  2OOQ A;  2AZR A;  1LAR A;  1G4U S;  2BGD A;  3QCC A;  4TVV A;  2F6Y A;  2J16 A;  2OUD A;  4R30 A;  2FJM A;  1LQF A;  2B3O A;  3EAX A;  2BGE A;  4RHG A;  2B4O A;  3V0G A;  4KI9 A;  2HNP A;  2CNG A;  1R6H A;  2VEU A;  2HB1 A;  1OET A;  2Q05 A;  3QCH A;  1XRI A;  1OHD A;  2VEW A;  4S0G A;  1FQ1 A;  3D1H A;  2GWO A;  1YTN A;  5BZZ A;  4Y2E A;  3NME A;  2CJZ A;  1XXP A;  3V0D A;  2QEP A;  4D3P A;  1PTV A;  2F6W A;  5KAB A;  1G1H A;  3EZZ A;  4WTY A;  4ZN5 A;  2B4S A; 
#chains in the Genus database with same CATH topology
 4RI5 A;  2CM2 A;  4GRY A;  3S4O A;  2BIJ A;  4R0T A;  3QKQ A;  2AHS A;  2CMC A;  2F00 A;  2GJT A;  4QBE A;  2I1Y A;  2J17 A;  2P6X A;  1Q6T A;  1P15 A;  5KA1 A;  1YGR A;  2JFH A;  2CM3 A;  4H1O A;  4BUC A;  1PYN A;  2XJA A;  2QBQ A;  2I6O A;  4WOH A;  4KYQ A;  5KA0 A;  4GWF A;  1T48 A;  2GCB A;  1OEM X;  3EU0 A;  2GP0 A;  3S4E A;  3S3K A;  2B07 A;  1G7F A;  5BZX A;  2VOS A;  2H02 A;  2C46 A;  2RF6 A;  1W7K A;  5KAC A;  3QCF A;  2BZL A;  2PSZ A;  3F99 A;  2H03 A;  3F9A A;  5I6V A;  2CNH A;  3U96 A;  1GG4 A;  3H2X A;  1JF7 A;  1T4J A;  3ZL8 A;  1WAX A;  1P31 A;  2NV5 A;  3M4U A;  3N2A A;  5GTJ A;  3QCK A;  3AWG A;  1YPT A;  1EEH A;  4WU2 A;  5M43 A;  2SHP A;  3D9C A;  4NYH A;  2H4V A;  5BX1 A;  1C85 A;  2QCJ A;  2M3V A;  3N0A A;  2QDP A;  2CMA A;  2ZMM A;  3LK7 A;  1BZC A;  1C87 A;  2I4G A;  2HC2 A;  3QCI A;  2QBR A;  1NO6 A;  1YTS A;  3V0F A;  1PA9 A;  2F6V A;  2VTD A;  4MBB A;  3A5J A;  1OHC A;  1PTY A;  5KA2 A;  3F9B A;  4NWG A;  1KAK A;  1PH0 A;  3A5K A;  3ZM2 A;  1Q6J A;  2CFV A;  4C13 A;  2PA5 A;  3ZMQ A;  1PA1 A;  2HC1 A;  4QUM A;  1ECV A;  1KAV A;  2H4G A;  5EHP A;  3RO1 A;  1XBO A;  5K9W A;  3EB1 A;  2A3K A;  1I57 A;  1J4X A;  1G1F A;  2NT2 A;  4QAH A;  4NND A;  2UAG A;  3QCG A;  2Y1O A;  4WU3 A;  4DGX A;  2NLK A;  2I4H A;  4GFU A;  1FGS A;  2ZN7 A;  2E0T A;  4C12 A;  1T49 A;  4GRZ A;  4AZ1 A;  2GC5 A;  2CMB A;  1U26 A;  5K9V A;  1I9T A;  1X24 A;  1P3D A;  1XXV A;  1JBV A;  4QAP A;  1D5R A;  2I4E A;  2Y67 A;  1UAG A;  2XPC A;  1YFO A;  4RH9 A;  5K25 A;  4CVL A;  1J6U A;  1XM2 A;  2ESB A;  2CNI A;  1ZCL A;  2CNF A;  1PTT A;  4GS0 A;  3O4S A;  4ICZ A;  2QDM A;  3D44 A;  2HNQ A;  3QCD A;  3D42 A;  3RGO A;  3F41 A;  5IBS A;  1O5Z A;  1QXK A;  1ZC0 A;  4B04 A;  3GXH A;  4BUB A;  1YTW A;  2JJD A;  4Y14 A;  1BZH A;  1L8K A;  1PTU A;  4HV4 A;  2Y2F A;  1NNY A;  1PXH A;  1E8C A;  2G59 A;  1ZCK A;  3BM8 A;  1RXD A;  1NL9 A;  3BLU A;  2UUP A;  4QUN A;  2IMG A;  2I5X A;  4OHI A;  1M3G A;  4RKK A;  4IKC A;  2PT0 A;  2I6M A;  3QCZ A;  3V0J A;  4RI4 A;  4GE2 A;  4GE6 A;  4PVG A;  5K23 A;  2DXP A;  2VEV A;  1EEN A;  1Q6N A;  3BRH A;  3PS5 A;  2YDU A;  4JMK A;  2NZ6 A;  3O4T A;  2I6P A;  4RDD A;  3QCB A;  5K24 A;  1FPR A;  1OEO X;  2BV5 A;  3NRS A;  2OZ5 A;  2FJN A;  1YN9 A;  4UAG A;  2H4K A;  4BPC A;  1U24 A;  1NZ7 A;  2G6Z A;  2OC3 A;  2AM1 A;  4RH5 A;  5BUG A;  2PI7 A;  2VEX A;  1FPZ A;  3QKP A;  5KA4 A;  4GFV A;  3V0I A;  3QCJ A;  1C84 A;  2F70 A;  1VHR A;  5A5F A;  5KA7 A;  3D1Q A;  5KAA A;  5IBM A;  3OMH A;  4HJP A;  4HJQ A;  2F6T A;  1GWZ A;  2FH7 A;  2I6I A;  4HRF A;  3SR9 A;  3ZM0 A;  1WCH A;  2B4P A;  3MMJ A;  4JNB A;  4I8N A;  3LJ8 A;  4QBW A;  4ZI4 A;  3ZM3 A;  1MKP A;  2PQ5 A;  3D1O A;  3MOW A;  2B4U A;  1I9S A;  3RZ2 A;  5LXQ B;  2AM2 A;  2HXP A;  5J8R A;  1YGU A;  2HY3 A;  3GXG A;  2GC6 A;  3I36 A;  2J16 B;  3AWE A;  3QCN A;  1WRM A;  2I42 A;  3AWF A;  1OEU A;  4H34 A;  2HVL A;  2F46 A;  5KA8 A;  3CM3 A;  2I6J A;  1G4W R;  2PBN A;  4OHD A;  1AAX A;  1NWE A;  4Z6B A;  2I75 A;  5KA3 A;  2B49 A;  2R0B A;  2CM7 A;  5EHR A;  1OES A;  2F71 A;  2VTE A;  1L8G A;  3B7O A;  4ZRT A;  2HCM A;  3QCL A;  1U25 A;  1V3A A;  3BLT A;  1YZ4 A;  2WGP A;  5AWX A;  2JFF A;  5KAD A;  1BZJ A;  1OHE A;  4ERC A;  1ONZ A;  1Q6S A;  4YAA A;  1A5Y A;  1Q1M A;  4KYR A;  3V0E A;  4JMJ A;  5HDE A;  2WJP A;  4JBC A;  3ZV2 A;  3OLR A;  1GQY A;  3CWE A;  3ZM1 A;  2CNE A;  2I3R A;  3MOZ A;  2NT7 A;  2VOR A;  5A5E A;  2H04 A;  4YR8 B;  4D3R A;  4NWF A;  2QBS A;  3I7Z A;  1RPM A;  4OHE A;  3ZM6 A;  1QZ0 A;  1YWF A;  3I80 A;  4OHL A;  1LYV A;  1C86 A;  3SME A;  2JFG A;  4GE5 A;  3O4U A;  1OEV A;  4NX8 A;  1JBW A;  3ZM5 A;  2X5O A;  2Y66 A;  1EEO A;  1JLN A;  1C83 A;  4R0S A;  4QF5 A;  3QCE A;  2I3U A;  5K22 A;  1W78 A;  3O5X A;  4CVM A;  3EMU A;  2P4D A;  2VEY A;  5MMZ B;  2F6F A;  1G1G A;  2Y68 A;  3QCM A;  2Y96 A;  4D3Q A;  2QCT A;  1SUG A;  1ONY A;  3MVN A;  3RGQ A;  5KA9 A;  2C7S A;  1GQQ A;  4ZIY A;  2NTA A;  1C88 A;  2CM8 A;  2QDC A;  1GFY A;  1Q6M A;  3O3L A;  4OHH A;  3V0H A;  3S3E A;  4PYH A;  2Q47 A;  2MBC A;  1Q6P A;  2QBP A;  3F81 A;  4CVK A;  2A8B A;  3UAG A;  4J51 A;  3S3H A;  1G7G A;  3S3F A;  4BJO A;  4DGP A;  1ZZW A;  3HN7 A;  3ZMP A;  2F6Z A;  1E0D A;  1NWL A;  2OOQ A;  2AZR A;  1LAR A;  1G4U S;  2BGD A;  3QCC A;  4TVV A;  2F6Y A;  2J16 A;  2OUD A;  4R30 A;  2FJM A;  1LQF A;  3EAX A;  2B3O A;  2WTZ A;  2BGE A;  4RHG A;  2B4O A;  4QDI A;  3V0G A;  4KI9 A;  2HNP A;  2CNG A;  2GCA A;  1R6H A;  2UUO A;  2VEU A;  2HB1 A;  3PYZ A;  1OET A;  2Q05 A;  3QCH A;  1XRI A;  1OHD A;  2VEW A;  4S0G A;  1FQ1 A;  3D1H A;  2GWO A;  1YTN A;  5BZZ A;  4Y2E A;  3NME A;  2CJZ A;  1XXP A;  3V0D A;  2QEP A;  4D3P A;  1PTV A;  2F6W A;  5KAB A;  1G1H A;  3EZZ A;  4WTY A;  4ZN5 A;  2B4S A; 
#chains in the Genus database with same CATH homology
 4RI5 A;  2CM2 A;  4GRY A;  3S4O A;  2BIJ A;  4R0T A;  3QKQ A;  2AHS A;  2CMC A;  4QBE A;  2GJT A;  2I1Y A;  2J17 A;  2P6X A;  1Q6T A;  1P15 A;  5KA1 A;  1YGR A;  2CM3 A;  4H1O A;  1PYN A;  2QBQ A;  2I6O A;  4WOH A;  4KYQ A;  5KA0 A;  4GWF A;  1T48 A;  1OEM X;  3EU0 A;  2GP0 A;  3S4E A;  3S3K A;  2B07 A;  1G7F A;  5BZX A;  2H02 A;  2C46 A;  2RF6 A;  5KAC A;  3QCF A;  2BZL A;  2PSZ A;  3F99 A;  2H03 A;  3F9A A;  5I6V A;  2CNH A;  3U96 A;  3H2X A;  1JF7 A;  1T4J A;  1WAX A;  2NV5 A;  3M4U A;  5GTJ A;  3QCK A;  3AWG A;  1YPT A;  4WU2 A;  5M43 A;  2SHP A;  3D9C A;  4NYH A;  2H4V A;  5BX1 A;  1C85 A;  2QCJ A;  2M3V A;  3N0A A;  2QDP A;  2CMA A;  2ZMM A;  1BZC A;  1C87 A;  2I4G A;  2HC2 A;  3QCI A;  2QBR A;  1NO6 A;  1YTS A;  3V0F A;  1PA9 A;  2F6V A;  4MBB A;  3A5J A;  1OHC A;  1PTY A;  5KA2 A;  3F9B A;  4NWG A;  1KAK A;  1PH0 A;  3A5K A;  3ZM2 A;  1Q6J A;  2CFV A;  2PA5 A;  3ZMQ A;  1PA1 A;  2HC1 A;  4QUM A;  1ECV A;  1KAV A;  2H4G A;  5EHP A;  3RO1 A;  1XBO A;  5K9W A;  3EB1 A;  2A3K A;  1I57 A;  1J4X A;  1G1F A;  2NT2 A;  4QAH A;  4NND A;  3QCG A;  4WU3 A;  4DGX A;  2NLK A;  2I4H A;  4GFU A;  2ZN7 A;  2E0T A;  1T49 A;  4GRZ A;  4AZ1 A;  2CMB A;  1U26 A;  5K9V A;  1I9T A;  1X24 A;  1XXV A;  4QAP A;  1D5R A;  2I4E A;  1YFO A;  4RH9 A;  5K25 A;  1XM2 A;  2ESB A;  2CNI A;  1ZCL A;  2CNF A;  1PTT A;  4GS0 A;  3O4S A;  4ICZ A;  2QDM A;  3D44 A;  2HNQ A;  3QCD A;  3D42 A;  3RGO A;  3F41 A;  5IBS A;  1QXK A;  1ZC0 A;  4B04 A;  3GXH A;  1YTW A;  2JJD A;  4Y14 A;  1BZH A;  1L8K A;  1PTU A;  2Y2F A;  1NNY A;  1PXH A;  2G59 A;  1ZCK A;  3BM8 A;  1RXD A;  1NL9 A;  3BLU A;  4QUN A;  2IMG A;  2I5X A;  4OHI A;  1M3G A;  4RKK A;  4IKC A;  2PT0 A;  2I6M A;  3V0J A;  4RI4 A;  4GE2 A;  4GE6 A;  4PVG A;  5K23 A;  2DXP A;  2VEV A;  1Q6N A;  1EEN A;  3BRH A;  3PS5 A;  2YDU A;  4JMK A;  2NZ6 A;  3O4T A;  2I6P A;  4RDD A;  3QCB A;  5K24 A;  1FPR A;  1OEO X;  2BV5 A;  2OZ5 A;  2FJN A;  1YN9 A;  2H4K A;  4BPC A;  1U24 A;  1NZ7 A;  2G6Z A;  2OC3 A;  4RH5 A;  5BUG A;  2PI7 A;  2VEX A;  1FPZ A;  3QKP A;  5KA4 A;  4GFV A;  3V0I A;  3QCJ A;  1C84 A;  2F70 A;  1VHR A;  5KA7 A;  3D1Q A;  5KAA A;  5IBM A;  3OMH A;  4HJP A;  4HJQ A;  2F6T A;  1GWZ A;  2FH7 A;  2I6I A;  4HRF A;  3SR9 A;  3ZM0 A;  1WCH A;  2B4P A;  3MMJ A;  4JNB A;  4I8N A;  3LJ8 A;  4QBW A;  4ZI4 A;  3ZM3 A;  1MKP A;  2PQ5 A;  3D1O A;  3MOW A;  2B4U A;  1I9S A;  3RZ2 A;  5LXQ B;  2HXP A;  5J8R A;  1YGU A;  2HY3 A;  3GXG A;  3I36 A;  2J16 B;  3AWE A;  3QCN A;  1WRM A;  2I42 A;  3AWF A;  1OEU A;  4H34 A;  2HVL A;  2F46 A;  5KA8 A;  3CM3 A;  2I6J A;  1G4W R;  2PBN A;  4OHD A;  1AAX A;  1NWE A;  4Z6B A;  2I75 A;  5KA3 A;  2B49 A;  2R0B A;  2CM7 A;  5EHR A;  1OES A;  2F71 A;  1L8G A;  3B7O A;  4ZRT A;  2HCM A;  3QCL A;  1U25 A;  1V3A A;  3BLT A;  1YZ4 A;  2WGP A;  5AWX A;  5KAD A;  1BZJ A;  1OHE A;  4ERC A;  1ONZ A;  1Q6S A;  4YAA A;  1A5Y A;  1Q1M A;  4KYR A;  3V0E A;  4JMJ A;  5HDE A;  4JBC A;  3ZV2 A;  3OLR A;  3CWE A;  3ZM1 A;  2CNE A;  2I3R A;  3MOZ A;  2NT7 A;  2H04 A;  4YR8 B;  4D3R A;  4NWF A;  2QBS A;  3I7Z A;  1RPM A;  4OHE A;  1QZ0 A;  1YWF A;  3I80 A;  4OHL A;  1LYV A;  1C86 A;  3SME A;  4GE5 A;  3O4U A;  1OEV A;  4NX8 A;  1EEO A;  1JLN A;  1C83 A;  4R0S A;  3QCE A;  2I3U A;  5K22 A;  3O5X A;  3EMU A;  2P4D A;  2VEY A;  5MMZ B;  2F6F A;  1G1G A;  3QCM A;  2Y96 A;  4D3Q A;  2QCT A;  1SUG A;  1ONY A;  3RGQ A;  5KA9 A;  2C7S A;  2NTA A;  1C88 A;  2CM8 A;  2QDC A;  1GFY A;  1Q6M A;  3O3L A;  4OHH A;  3V0H A;  3S3E A;  4PYH A;  2Q47 A;  2MBC A;  1Q6P A;  2QBP A;  3F81 A;  2A8B A;  4J51 A;  3S3H A;  1G7G A;  3S3F A;  4BJO A;  4DGP A;  1ZZW A;  3ZMP A;  2F6Z A;  1NWL A;  2OOQ A;  2AZR A;  1LAR A;  1G4U S;  2BGD A;  3QCC A;  4TVV A;  2F6Y A;  2J16 A;  2OUD A;  4R30 A;  2FJM A;  1LQF A;  2B3O A;  3EAX A;  2BGE A;  4RHG A;  2B4O A;  3V0G A;  4KI9 A;  2HNP A;  2CNG A;  1R6H A;  2VEU A;  2HB1 A;  1OET A;  2Q05 A;  3QCH A;  1XRI A;  1OHD A;  2VEW A;  4S0G A;  1FQ1 A;  3D1H A;  2GWO A;  1YTN A;  5BZZ A;  4Y2E A;  3NME A;  2CJZ A;  1XXP A;  3V0D A;  2QEP A;  4D3P A;  1PTV A;  2F6W A;  5KAB A;  1G1H A;  3EZZ A;  4WTY A;  4ZN5 A;  2B4S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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