2CM8A

Structural basis for inhibition of protein tyrosine phosphatase 1b by isothiazolidinone heterocyclic phosphonate mimetics
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
297
structure length
297
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
total genus 107
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-05-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2cm8A00
3AWFA 4GS0A 2P4DA 3BLUA 2OUDA 4JMJA 1QXKA 2WGPA 4Z6BA 2CNFA 4NNDA 3S3EA 4GWFA 2CNGA 4JBCA 2Q47A 2A3KA 2B4OA 2DXPA 4OHDA 2FJMA 3QCGA 3ZMQA 4GRYA 4JNBA 3S4OA 3SMEA 4DGXA 1PTVA 2Q05A 2F46A 3H2XA 3EZZA 5KA3A 3O4UA 3V0IA 2H02A 2I6JA 1PXHA 1WCHA 1XBOA 1NZ7A 3GXGA 3ZV2A 3RGQA 5KABA 2QBQA 1KAKA 2VEUA 3S3KA 1YGRA 1ZZWA 4BPCA 3M4UA 3V0EA 1ONZA 1RXDA 4QBEA 2I6PA 1EENA 3QCDA 1G1GA 5BZXA 4RHGA 1G7GA 2BGDA 1BZHA 1ECVA 4OHHA 3QCEA 3BLTA 2YDUA 2CNIA 2B3OA 1C84A 4ICZA 4D3QA 2HNQA 4TVVA 5KA1A 2HCMA 3ZM1A 2CMBA 4Y2EA 5MMZB 1OEOX 4JMKA 4WOHA 3V0JA 4D3PA 5J8RA 3B7OA 3D1OA 1G4WR 3PS5A 2G6ZA 1T49A 3OLRA 2ZMMA 3U96A 1YTWA 4RDDA 5HDEA 1MKPA 2B4PA 2PI7A 1U26A 1PTUA 2G59A 3BM8A 1Q6JA 1T48A 1Q6PA 4R30A 2CM8A 4KYQA 4MBBA 1XXPA 3QCCA 1LARA 2H4KA 1G1HA 2BZLA 2J16B 2R0BA 1PTYA 4DGPA 1JLNA 1LYVA 2CMAA 4BJOA 3V0FA 2CMCA 3EAXA 3O4SA 4RKKA 2GWOA 3D1HA 1R6HA 1J4XA 1Q6NA 1OEUA 1PH0A 2NTAA 2QBRA 3QKQA 2B4UA 1YN9A 1YGUA 5I6VA 2NLKA 2QBSA 1YTNA 5LXQB 4QUNA 2B4SA 2B07A 5KA7A 4GFVA 4QBWA 2I3UA 1LQFA 1T4JA 1GFYA 4I8NA 5IBMA 4NYHA 3O5XA 1Q1MA 2OC3A 1Q6TA 3EB1A 2VEWA 1PA9A 4GE5A 2QDCA 4YR8B 1OEMX 2BIJA 1RPMA 2CM7A 2I6IA 3QCFA 1P15A 2AHSA 3S3FA 3EMUA 1X24A 2E0TA 1Q6SA 5K24A 2CJZA 1GWZA 3GXHA 5KACA 4NWGA 4H34A 1ZCKA 2ESBA 2A8BA 1D5RA 1PYNA 3BRHA 4NX8A 3D44A 4AZ1A 4GE6A 3O4TA 2VEYA 3RO1A 4OHIA 2PBNA 1OHEA 2I5XA 4PYHA 4R0SA 5KA8A 2MBCA 2HC1A 3QCBA 3MOZA 3QKPA 3QCMA 3AWGA 2I4GA 1WRMA 2RF6A 4ZI4A 2I1YA 3F81A 1PA1A 4PVGA 3SR9A 2J16A 2Y96A 1YTSA 2H03A 2CNHA 1U24A 3QCJA 5M43A 3F9BA 2F6YA 1L8GA 2I6OA 1WAXA 2NT2A 2I42A 1FPRA 4IKCA 4HJQA 4S0GA 2VEVA 3O3LA 1XXVA 5EHRA 2HNPA 4HRFA 1A5YA 2OOQA 2OZ5A 4Y14A 4WU2A 4QAPA 3MMJA 5BZZA 5GTJA 3V0GA 4RH5A 3ZMPA 3V0DA 1M3GA 2QDMA 1L8KA 4OHLA 2F6TA 2I75A 2BV5A 1ZCLA 5KA9A 5K22A 4D3RA 1Q6MA 1NO6A 2PA5A 3AWEA 5AWXA 5KA2A 4H1OA 1XRIA 1SUGA 4GRZA 1OESA 3S3HA 2CNEA 2F6VA 2FH7A 4GE2A 2SHPA 1YPTA 2B49A 1PTTA 1U25A 1JF7A 3A5JA 3ZM3A 4ERCA 2F6WA 1YWFA 1I57A 1C86A 5K23A 3ZM0A 1XM2A 3QCLA 2NZ6A 2QDPA 3F9AA 4ZN5A 1C85A 4GFUA 2CM2A 2ZN7A 2I4EA 2QBPA 2HB1A 1OETA 2PQ5A 5EHPA 3CWEA 1I9SA 4J51A 3ZM2A 2M3VA 3EU0A 4B04A 3RZ2A 2VEXA 5BUGA 2F71A 4QAHA 3A5KA 3QCHA 2I6MA 1YFOA 5BX1A 2JJDA 3F41A 1C88A 3QCNA 3D1QA 2QEPA 3MOWA 1BZCA 1NNYA 2NT7A 1OEVA 2I4HA 2HXPA 1G1FA 2AZRA 2H4GA 1C83A 1OHDA 5IBSA 5K9VA 1FPZA 5KA4A 3I36A 4ZRTA 2GP0A 1ZC0A 2H04A 2BGEA 3OMHA 4NWFA 1EEOA 2QCTA 4RH9A 2CFVA 3N0AA 5KA0A 1AAXA 1FQ1A 1G4US 3QCKA 4RI5A 3CM3A 4KI9A 1ONYA 2PSZA 1QZ0A 3D9CA 4HJPA 5KADA 2F6ZA 5KAAA 3F99A 2GJTA 4OHEA 2P6XA 1YZ4A 2PT0A 2QCJA 1I9TA 5K25A 3V0HA 4KYRA 4RI4A 2CM3A 2H4VA 3S4EA 1G7FA 1NL9A 3NMEA 1NWLA 1NWEA 2HVLA 4WU3A 3I7ZA 4WTYA 3RGOA 4YAAA 1VHRA 1V3AA 3I80A 3D42A 1BZJA 2I3RA 2HY3A 2HC2A 2IMGA 3LJ8A 2NV5A 2F6FA 4R0TA 2FJNA 2C46A 2Y2FA 1KAVA 3QCIA 1OHCA 2F70A 2J17A 5K9WA 4QUMA 1C87A 2C7SA
chains in the Genus database with same CATH superfamily
3AWFA 4GS0A 5A5FA 2P4DA 3BLUA 2OUDA 2WJPA 4JMJA 1QXKA 2WGPA 4Z6BA 2CNFA 4NNDA 3S3EA 4GWFA 2CNGA 4JBCA 2Q47A 2A3KA 2B4OA 2DXPA 2Y1OA 4OHDA 2FJMA 3QCGA 3ZMQA 4GRYA 4JNBA 3S4OA 3SMEA 4DGXA 1PTVA 2Q05A 2F46A 3H2XA 3EZZA 5KA3A 3O4UA 3V0IA 2H02A 3UAGA 4CVKA 2I6JA 1PXHA 1WCHA 1XBOA 2XJAA 1NZ7A 3GXGA 3ZV2A 3RGQA 5KABA 2QBQA 1KAKA 2VEUA 1GQQA 3S3KA 2GC5A 1YGRA 1ZZWA 2UUPA 4BPCA 3M4UA 3V0EA 1ONZA 1RXDA 4QBEA 2I6PA 1EENA 3QCDA 1G1GA 5BZXA 4RHGA 1G7GA 2BGDA 1BZHA 1ECVA 4OHHA 3QCEA 3N2AA 3BLTA 2AM2A 2YDUA 3NRSA 2CNIA 2B3OA 1C84A 4ICZA 4D3QA 2HNQA 1W7KA 4TVVA 2GC6A 5KA1A 3ZL8A 2HCMA 3ZM1A 2CMBA 4Y2EA 5MMZB 1OEOX 4JMKA 4WOHA 3V0JA 2AM1A 4D3PA 5J8RA 3B7OA 3D1OA 1G4WR 3PS5A 2G6ZA 3MVNA 1T49A 3OLRA 1EEHA 1P31A 2ZMMA 3U96A 1YTWA 4CVMA 4RDDA 5HDEA 1MKPA 2B4PA 2PI7A 1U26A 1PTUA 2G59A 3BM8A 1Q6JA 1T48A 1Q6PA 4R30A 2CM8A 2F00A 4KYQA 4MBBA 1XXPA 3QCCA 2GCAA 1LARA 2H4KA 1G1HA 2BZLA 2J16B 2R0BA 1PTYA 4DGPA 1JLNA 1LYVA 2CMAA 4BJOA 4UAGA 2JFHA 3V0FA 2CMCA 3EAXA 3O4SA 4RKKA 2JFGA 2GWOA 3D1HA 1R6HA 1J4XA 1Q6NA 1OEUA 1PH0A 2NTAA 2QBRA 3QKQA 2B4UA 1YN9A 1YGUA 5I6VA 2NLKA 2QBSA 1YTNA 5LXQB 4QUNA 2B4SA 2B07A 5KA7A 4GFVA 4QBWA 2I3UA 1LQFA 1T4JA 1GFYA 4I8NA 5IBMA 4NYHA 3O5XA 1Q1MA 2OC3A 1Q6TA 3EB1A 2VEWA 1PA9A 4GE5A 2QDCA 4YR8B 1OEMX 2BIJA 2X5OA 1RPMA 2CM7A 2I6IA 3QCFA 1P15A 2AHSA 3S3FA 3EMUA 1X24A 2E0TA 1Q6SA 5K24A 2CJZA 1GWZA 3GXHA 5KACA 4NWGA 4H34A 1ZCKA 2ESBA 2A8BA 4QF5A 1D5RA 1W78A 2Y67A 1PYNA 3BRHA 4NX8A 3D44A 4AZ1A 4GE6A 3O4TA 2VEYA 3RO1A 4OHIA 2PBNA 1OHEA 2I5XA 4PYHA 4R0SA 5KA8A 2MBCA 2HC1A 4CVLA 3QCBA 3MOZA 3QKPA 3QCMA 5A5EA 3AWGA 2I4GA 1WRMA 2RF6A 4ZI4A 2I1YA 3F81A 1FGSA 4C13A 1PA1A 4PVGA 3SR9A 2J16A 2Y96A 1YTSA 4BUBA 2H03A 2CNHA 2VTDA 1U24A 3QCJA 5M43A 3F9BA 2F6YA 1L8GA 2I6OA 1WAXA 2NT2A 2I42A 1FPRA 4IKCA 4HJQA 4S0GA 2VEVA 3O3LA 1XXVA 5EHRA 2HNPA 4HRFA 1A5YA 2OOQA 2OZ5A 4Y14A 4WU2A 4QAPA 3MMJA 5BZZA 5GTJA 3V0GA 4RH5A 3ZMPA 3V0DA 1M3GA 2QDMA 1L8KA 4BUCA 4OHLA 2F6TA 2I75A 2BV5A 1ZCLA 5KA9A 1GG4A 1E0DA 5K22A 1UAGA 4D3RA 1Q6MA 1NO6A 2PA5A 3AWEA 5AWXA 5KA2A 4H1OA 1XRIA 1SUGA 4C12A 4GRZA 1OESA 3S3HA 2CNEA 2F6VA 2FH7A 4GE2A 2SHPA 2VORA 1YPTA 2B49A 1PTTA 1U25A 1JF7A 3A5JA 3ZM3A 4ERCA 2F6WA 1YWFA 1I57A 1C86A 2XPCA 5K23A 3ZM0A 1XM2A 3QCLA 1E8CA 2NZ6A 2QDPA 3F9AA 4ZN5A 3ZM6A 1C85A 4GFUA 2CM2A 2ZN7A 2UUOA 2VTEA 2I4EA 1JBWA 2QBPA 2HB1A 1OETA 2PQ5A 5EHPA 3CWEA 1I9SA 4J51A 3ZM2A 4ZIYA 2M3VA 3EU0A 4B04A 3ZM5A 3RZ2A 2VEXA 2GCBA 5BUGA 2F71A 4QAHA 3A5KA 1GQYA 3QCHA 2I6MA 1YFOA 5BX1A 2JJDA 3F41A 1C88A 2QEPA 3D1QA 3QCNA 3MOWA 1BZCA 1NNYA 2NT7A 2VOSA 1OEVA 2I4HA 2HXPA 1G1FA 2AZRA 2H4GA 1C83A 1OHDA 5IBSA 5K9VA 1FPZA 5KA4A 3I36A 4ZRTA 2GP0A 1ZC0A 2H04A 2BGEA 3OMHA 4NWFA 1EEOA 2QCTA 4RH9A 2CFVA 3N0AA 5KA0A 1AAXA 1FQ1A 1G4US 3QCKA 4RI5A 1O5ZA 3CM3A 2UAGA 4KI9A 1ONYA 1J6UA 2PSZA 1QZ0A 3D9CA 4HJPA 2Y68A 5KADA 2F6ZA 5KAAA 3F99A 2GJTA 4OHEA 2Y66A 2P6XA 1YZ4A 1JBVA 2PT0A 2QCJA 1I9TA 5K25A 3V0HA 4KYRA 4RI4A 2CM3A 2H4VA 3S4EA 1G7FA 1NL9A 3HN7A 4QDIA 2WTZA 3NMEA 1NWLA 1NWEA 2HVLA 4WU3A 3I7ZA 4WTYA 3LK7A 3RGOA 4YAAA 4HV4A 1VHRA 1V3AA 3I80A 3D42A 1BZJA 2I3RA 2HY3A 2HC2A 2IMGA 3LJ8A 3PYZA 2NV5A 2F6FA 4R0TA 2FJNA 3QCZA 2C46A 2Y2FA 1KAVA 3QCIA 2JFFA 1OHCA 2F70A 2J17A 5K9WA 4QUMA 1C87A 1P3DA 2C7SA
chains in the Genus database with same CATH topology
3AWFA 4GS0A 2P4DA 3BLUA 2OUDA 4JMJA 1QXKA 2WGPA 4Z6BA 2CNFA 4NNDA 3S3EA 4GWFA 2CNGA 4JBCA 2Q47A 2A3KA 2B4OA 2DXPA 4OHDA 2FJMA 3QCGA 3ZMQA 4GRYA 4JNBA 3S4OA 3SMEA 4DGXA 1PTVA 2Q05A 2F46A 3H2XA 3EZZA 5KA3A 3O4UA 3V0IA 2H02A 2I6JA 1PXHA 1WCHA 1XBOA 1NZ7A 3GXGA 3ZV2A 3RGQA 5KABA 2QBQA 1KAKA 2VEUA 3S3KA 1YGRA 1ZZWA 4BPCA 3M4UA 3V0EA 1ONZA 1RXDA 4QBEA 2I6PA 1EENA 3QCDA 1G1GA 5BZXA 4RHGA 1G7GA 2BGDA 1BZHA 1ECVA 4OHHA 3QCEA 3BLTA 2YDUA 2CNIA 2B3OA 1C84A 4ICZA 4D3QA 2HNQA 4TVVA 5KA1A 2HCMA 3ZM1A 2CMBA 4Y2EA 5MMZB 1OEOX 4JMKA 4WOHA 3V0JA 4D3PA 5J8RA 3B7OA 3D1OA 1G4WR 3PS5A 2G6ZA 1T49A 3OLRA 2ZMMA 3U96A 1YTWA 4RDDA 5HDEA 1MKPA 2B4PA 2PI7A 1U26A 1PTUA 2G59A 3BM8A 1Q6JA 1T48A 1Q6PA 4R30A 2CM8A 4KYQA 4MBBA 1XXPA 3QCCA 1LARA 2H4KA 1G1HA 2BZLA 2J16B 2R0BA 1PTYA 4DGPA 1JLNA 1LYVA 2CMAA 4BJOA 3V0FA 2CMCA 3EAXA 3O4SA 4RKKA 2GWOA 3D1HA 1R6HA 1J4XA 1Q6NA 1OEUA 1PH0A 2NTAA 2QBRA 3QKQA 2B4UA 1YN9A 1YGUA 5I6VA 2NLKA 2QBSA 1YTNA 5LXQB 4QUNA 2B4SA 2B07A 5KA7A 4GFVA 4QBWA 2I3UA 1LQFA 1T4JA 1GFYA 4I8NA 5IBMA 4NYHA 3O5XA 1Q1MA 2OC3A 1Q6TA 3EB1A 2VEWA 1PA9A 4GE5A 2QDCA 4YR8B 1OEMX 2BIJA 1RPMA 2CM7A 2I6IA 3QCFA 1P15A 2AHSA 3S3FA 3EMUA 1X24A 2E0TA 1Q6SA 5K24A 2CJZA 1GWZA 3GXHA 5KACA 4NWGA 4H34A 1ZCKA 2ESBA 2A8BA 1D5RA 1PYNA 3BRHA 4NX8A 3D44A 4AZ1A 4GE6A 3O4TA 2VEYA 3RO1A 4OHIA 2PBNA 1OHEA 2I5XA 4PYHA 4R0SA 5KA8A 2MBCA 2HC1A 3QCBA 3MOZA 3QKPA 3QCMA 3AWGA 2I4GA 1WRMA 2RF6A 4ZI4A 2I1YA 3F81A 1PA1A 4PVGA 3SR9A 2J16A 2Y96A 1YTSA 2H03A 2CNHA 1U24A 3QCJA 5M43A 3F9BA 2F6YA 1L8GA 2I6OA 1WAXA 2NT2A 2I42A 1FPRA 4IKCA 4HJQA 4S0GA 2VEVA 3O3LA 1XXVA 5EHRA 2HNPA 4HRFA 1A5YA 2OOQA 2OZ5A 4Y14A 4WU2A 4QAPA 3MMJA 5BZZA 5GTJA 3V0GA 4RH5A 3ZMPA 3V0DA 1M3GA 2QDMA 1L8KA 4OHLA 2F6TA 2I75A 2BV5A 1ZCLA 5KA9A 5K22A 4D3RA 1Q6MA 1NO6A 2PA5A 3AWEA 5AWXA 5KA2A 4H1OA 1XRIA 1SUGA 4GRZA 1OESA 3S3HA 2CNEA 2F6VA 2FH7A 4GE2A 2SHPA 1YPTA 2B49A 1PTTA 1U25A 1JF7A 3A5JA 3ZM3A 4ERCA 2F6WA 1YWFA 1I57A 1C86A 5K23A 3ZM0A 1XM2A 3QCLA 2NZ6A 2QDPA 3F9AA 4ZN5A 1C85A 4GFUA 2CM2A 2ZN7A 2I4EA 2QBPA 2HB1A 1OETA 2PQ5A 5EHPA 3CWEA 1I9SA 4J51A 3ZM2A 2M3VA 3EU0A 4B04A 3RZ2A 2VEXA 5BUGA 2F71A 4QAHA 3A5KA 3QCHA 2I6MA 1YFOA 5BX1A 2JJDA 3F41A 1C88A 3QCNA 3D1QA 2QEPA 3MOWA 1BZCA 1NNYA 2NT7A 1OEVA 2I4HA 2HXPA 1G1FA 2AZRA 2H4GA 1C83A 1OHDA 5IBSA 5K9VA 1FPZA 5KA4A 3I36A 4ZRTA 2GP0A 1ZC0A 2H04A 2BGEA 3OMHA 4NWFA 1EEOA 2QCTA 4RH9A 2CFVA 3N0AA 5KA0A 1AAXA 1FQ1A 1G4US 3QCKA 4RI5A 3CM3A 4KI9A 1ONYA 2PSZA 1QZ0A 3D9CA 4HJPA 5KADA 2F6ZA 5KAAA 3F99A 2GJTA 4OHEA 2P6XA 1YZ4A 2PT0A 2QCJA 1I9TA 5K25A 3V0HA 4KYRA 4RI4A 2CM3A 2H4VA 3S4EA 1G7FA 1NL9A 3NMEA 1NWLA 1NWEA 2HVLA 4WU3A 3I7ZA 4WTYA 3RGOA 4YAAA 1VHRA 1V3AA 3I80A 3D42A 1BZJA 2I3RA 2HY3A 2HC2A 2IMGA 3LJ8A 2NV5A 2F6FA 4R0TA 2FJNA 2C46A 2Y2FA 1KAVA 3QCIA 1OHCA 2F70A 2J17A 5K9WA 4QUMA 1C87A 2C7SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3AWF A;  4GS0 A;  2P4D A;  3BLU A;  2OUD A;  4JMJ A;  1QXK A;  2WGP A;  4Z6B A;  2CNF A;  4NND A;  3S3E A;  4GWF A;  2CNG A;  4JBC A;  2Q47 A;  2A3K A;  2B4O A;  2DXP A;  4OHD A;  2FJM A;  3QCG A;  3ZMQ A;  4GRY A;  4JNB A;  3S4O A;  3SME A;  4DGX A;  1PTV A;  2Q05 A;  2F46 A;  3H2X A;  3EZZ A;  5KA3 A;  3O4U A;  3V0I A;  2H02 A;  2I6J A;  1PXH A;  1WCH A;  1XBO A;  1NZ7 A;  3GXG A;  3ZV2 A;  3RGQ A;  5KAB A;  2QBQ A;  1KAK A;  2VEU A;  3S3K A;  1YGR A;  1ZZW A;  4BPC A;  3M4U A;  3V0E A;  1ONZ A;  1RXD A;  4QBE A;  2I6P A;  1EEN A;  3QCD A;  1G1G A;  5BZX A;  4RHG A;  1G7G A;  2BGD A;  1BZH A;  1ECV A;  4OHH A;  3QCE A;  3BLT A;  2YDU A;  2CNI A;  2B3O A;  1C84 A;  4ICZ A;  4D3Q A;  2HNQ A;  4TVV A;  5KA1 A;  2HCM A;  3ZM1 A;  2CMB A;  4Y2E A;  5MMZ B;  1OEO X;  4JMK A;  4WOH A;  3V0J A;  4D3P A;  5J8R A;  3B7O A;  3D1O A;  1G4W R;  3PS5 A;  2G6Z A;  1T49 A;  3OLR A;  2ZMM A;  3U96 A;  1YTW A;  4RDD A;  5HDE A;  1MKP A;  2B4P A;  2PI7 A;  1U26 A;  1PTU A;  2G59 A;  3BM8 A;  1Q6J A;  1T48 A;  1Q6P A;  4R30 A;  2CM8 A;  4KYQ A;  4MBB A;  1XXP A;  3QCC A;  1LAR A;  2H4K A;  1G1H A;  2BZL A;  2J16 B;  2R0B A;  1PTY A;  4DGP A;  1JLN A;  1LYV A;  2CMA A;  4BJO A;  3V0F A;  2CMC A;  3EAX A;  3O4S A;  4RKK A;  2GWO A;  3D1H A;  1R6H A;  1J4X A;  1Q6N A;  1OEU A;  1PH0 A;  2NTA A;  2QBR A;  3QKQ A;  2B4U A;  1YN9 A;  1YGU A;  5I6V A;  2NLK A;  2QBS A;  1YTN A;  5LXQ B;  4QUN A;  2B4S A;  2B07 A;  5KA7 A;  4GFV A;  4QBW A;  2I3U A;  1LQF A;  1T4J A;  1GFY A;  4I8N A;  5IBM A;  4NYH A;  3O5X A;  1Q1M A;  2OC3 A;  1Q6T A;  3EB1 A;  2VEW A;  1PA9 A;  4GE5 A;  2QDC A;  4YR8 B;  1OEM X;  2BIJ A;  1RPM A;  2CM7 A;  2I6I A;  3QCF A;  1P15 A;  2AHS A;  3S3F A;  3EMU A;  1X24 A;  2E0T A;  1Q6S A;  5K24 A;  2CJZ A;  1GWZ A;  3GXH A;  5KAC A;  4NWG A;  4H34 A;  1ZCK A;  2ESB A;  2A8B A;  1D5R A;  1PYN A;  3BRH A;  4NX8 A;  3D44 A;  4AZ1 A;  4GE6 A;  3O4T A;  2VEY A;  3RO1 A;  4OHI A;  2PBN A;  1OHE A;  2I5X A;  4PYH A;  4R0S A;  5KA8 A;  2MBC A;  2HC1 A;  3QCB A;  3MOZ A;  3QKP A;  3QCM A;  3AWG A;  2I4G A;  1WRM A;  2RF6 A;  4ZI4 A;  2I1Y A;  3F81 A;  1PA1 A;  4PVG A;  3SR9 A;  2J16 A;  2Y96 A;  1YTS A;  2H03 A;  2CNH A;  1U24 A;  3QCJ A;  5M43 A;  3F9B A;  2F6Y A;  1L8G A;  2I6O A;  1WAX A;  2NT2 A;  2I42 A;  1FPR A;  4IKC A;  4HJQ A;  4S0G A;  2VEV A;  3O3L A;  1XXV A;  5EHR A;  2HNP A;  4HRF A;  1A5Y A;  2OOQ A;  2OZ5 A;  4Y14 A;  4WU2 A;  4QAP A;  3MMJ A;  5BZZ A;  5GTJ A;  3V0G A;  4RH5 A;  3ZMP A;  3V0D A;  1M3G A;  2QDM A;  1L8K A;  4OHL A;  2F6T A;  2I75 A;  2BV5 A;  1ZCL A;  5KA9 A;  5K22 A;  4D3R A;  1Q6M A;  1NO6 A;  2PA5 A;  3AWE A;  5AWX A;  5KA2 A;  4H1O A;  1XRI A;  1SUG A;  4GRZ A;  1OES A;  3S3H A;  2CNE A;  2F6V A;  2FH7 A;  4GE2 A;  2SHP A;  1YPT A;  2B49 A;  1PTT A;  1U25 A;  1JF7 A;  3A5J A;  3ZM3 A;  4ERC A;  2F6W A;  1YWF A;  1I57 A;  1C86 A;  5K23 A;  3ZM0 A;  1XM2 A;  3QCL A;  2NZ6 A;  2QDP A;  3F9A A;  4ZN5 A;  1C85 A;  4GFU A;  2CM2 A;  2ZN7 A;  2I4E A;  2QBP A;  2HB1 A;  1OET A;  2PQ5 A;  5EHP A;  3CWE A;  1I9S A;  4J51 A;  3ZM2 A;  2M3V A;  3EU0 A;  4B04 A;  3RZ2 A;  2VEX A;  5BUG A;  2F71 A;  4QAH A;  3A5K A;  3QCH A;  2I6M A;  1YFO A;  5BX1 A;  2JJD A;  3F41 A;  1C88 A;  3QCN A;  3D1Q A;  2QEP A;  3MOW A;  1BZC A;  1NNY A;  2NT7 A;  1OEV A;  2I4H A;  2HXP A;  1G1F A;  2AZR A;  2H4G A;  1C83 A;  1OHD A;  5IBS A;  5K9V A;  1FPZ A;  5KA4 A;  3I36 A;  4ZRT A;  2GP0 A;  1ZC0 A;  2H04 A;  2BGE A;  3OMH A;  4NWF A;  1EEO A;  2QCT A;  4RH9 A;  2CFV A;  3N0A A;  5KA0 A;  1AAX A;  1FQ1 A;  1G4U S;  3QCK A;  4RI5 A;  3CM3 A;  4KI9 A;  1ONY A;  2PSZ A;  1QZ0 A;  3D9C A;  4HJP A;  5KAD A;  2F6Z A;  5KAA A;  3F99 A;  2GJT A;  4OHE A;  2P6X A;  1YZ4 A;  2PT0 A;  2QCJ A;  1I9T A;  5K25 A;  3V0H A;  4KYR A;  4RI4 A;  2CM3 A;  2H4V A;  3S4E A;  1G7F A;  1NL9 A;  3NME A;  1NWL A;  1NWE A;  2HVL A;  4WU3 A;  3I7Z A;  4WTY A;  3RGO A;  4YAA A;  1VHR A;  1V3A A;  3I80 A;  3D42 A;  1BZJ A;  2I3R A;  2HY3 A;  2HC2 A;  2IMG A;  3LJ8 A;  2NV5 A;  2F6F A;  4R0T A;  2FJN A;  2C46 A;  2Y2F A;  1KAV A;  3QCI A;  1OHC A;  2F70 A;  2J17 A;  5K9W A;  4QUM A;  1C87 A;  2C7S A; 
#chains in the Genus database with same CATH topology
 3AWF A;  4GS0 A;  5A5F A;  2P4D A;  3BLU A;  2OUD A;  2WJP A;  4JMJ A;  1QXK A;  2WGP A;  4Z6B A;  2CNF A;  4NND A;  3S3E A;  4GWF A;  2CNG A;  4JBC A;  2Q47 A;  2A3K A;  2B4O A;  2DXP A;  2Y1O A;  4OHD A;  2FJM A;  3QCG A;  3ZMQ A;  4GRY A;  4JNB A;  3S4O A;  3SME A;  4DGX A;  1PTV A;  2Q05 A;  2F46 A;  3H2X A;  3EZZ A;  5KA3 A;  3O4U A;  3V0I A;  2H02 A;  3UAG A;  4CVK A;  2I6J A;  1PXH A;  1WCH A;  1XBO A;  2XJA A;  1NZ7 A;  3GXG A;  3ZV2 A;  3RGQ A;  5KAB A;  2QBQ A;  1KAK A;  2VEU A;  1GQQ A;  3S3K A;  2GC5 A;  1YGR A;  1ZZW A;  2UUP A;  4BPC A;  3M4U A;  3V0E A;  1ONZ A;  1RXD A;  4QBE A;  2I6P A;  1EEN A;  3QCD A;  1G1G A;  5BZX A;  4RHG A;  1G7G A;  2BGD A;  1BZH A;  1ECV A;  4OHH A;  3QCE A;  3N2A A;  3BLT A;  2AM2 A;  2YDU A;  3NRS A;  2CNI A;  2B3O A;  1C84 A;  4ICZ A;  4D3Q A;  2HNQ A;  1W7K A;  4TVV A;  2GC6 A;  5KA1 A;  3ZL8 A;  2HCM A;  3ZM1 A;  2CMB A;  4Y2E A;  5MMZ B;  1OEO X;  4JMK A;  4WOH A;  3V0J A;  2AM1 A;  4D3P A;  5J8R A;  3B7O A;  3D1O A;  1G4W R;  3PS5 A;  2G6Z A;  3MVN A;  1T49 A;  3OLR A;  1EEH A;  1P31 A;  2ZMM A;  3U96 A;  1YTW A;  4CVM A;  4RDD A;  5HDE A;  1MKP A;  2B4P A;  2PI7 A;  1U26 A;  1PTU A;  2G59 A;  3BM8 A;  1Q6J A;  1T48 A;  1Q6P A;  4R30 A;  2CM8 A;  2F00 A;  4KYQ A;  4MBB A;  1XXP A;  3QCC A;  2GCA A;  1LAR A;  2H4K A;  1G1H A;  2BZL A;  2J16 B;  2R0B A;  1PTY A;  4DGP A;  1JLN A;  1LYV A;  2CMA A;  4BJO A;  4UAG A;  2JFH A;  3V0F A;  2CMC A;  3EAX A;  3O4S A;  4RKK A;  2JFG A;  2GWO A;  3D1H A;  1R6H A;  1J4X A;  1Q6N A;  1OEU A;  1PH0 A;  2NTA A;  2QBR A;  3QKQ A;  2B4U A;  1YN9 A;  1YGU A;  5I6V A;  2NLK A;  2QBS A;  1YTN A;  5LXQ B;  4QUN A;  2B4S A;  2B07 A;  5KA7 A;  4GFV A;  4QBW A;  2I3U A;  1LQF A;  1T4J A;  1GFY A;  4I8N A;  5IBM A;  4NYH A;  3O5X A;  1Q1M A;  2OC3 A;  1Q6T A;  3EB1 A;  2VEW A;  1PA9 A;  4GE5 A;  2QDC A;  4YR8 B;  1OEM X;  2BIJ A;  2X5O A;  1RPM A;  2CM7 A;  2I6I A;  3QCF A;  1P15 A;  2AHS A;  3S3F A;  3EMU A;  1X24 A;  2E0T A;  1Q6S A;  5K24 A;  2CJZ A;  1GWZ A;  3GXH A;  5KAC A;  4NWG A;  4H34 A;  1ZCK A;  2ESB A;  2A8B A;  4QF5 A;  1D5R A;  1W78 A;  2Y67 A;  1PYN A;  3BRH A;  4NX8 A;  3D44 A;  4AZ1 A;  4GE6 A;  3O4T A;  2VEY A;  3RO1 A;  4OHI A;  2PBN A;  1OHE A;  2I5X A;  4PYH A;  4R0S A;  5KA8 A;  2MBC A;  2HC1 A;  4CVL A;  3QCB A;  3MOZ A;  3QKP A;  3QCM A;  5A5E A;  3AWG A;  2I4G A;  1WRM A;  2RF6 A;  4ZI4 A;  2I1Y A;  3F81 A;  1FGS A;  4C13 A;  1PA1 A;  4PVG A;  3SR9 A;  2J16 A;  2Y96 A;  1YTS A;  4BUB A;  2H03 A;  2CNH A;  2VTD A;  1U24 A;  3QCJ A;  5M43 A;  3F9B A;  2F6Y A;  1L8G A;  2I6O A;  1WAX A;  2NT2 A;  2I42 A;  1FPR A;  4IKC A;  4HJQ A;  4S0G A;  2VEV A;  3O3L A;  1XXV A;  5EHR A;  2HNP A;  4HRF A;  1A5Y A;  2OOQ A;  2OZ5 A;  4Y14 A;  4WU2 A;  4QAP A;  3MMJ A;  5BZZ A;  5GTJ A;  3V0G A;  4RH5 A;  3ZMP A;  3V0D A;  1M3G A;  2QDM A;  1L8K A;  4BUC A;  4OHL A;  2F6T A;  2I75 A;  2BV5 A;  1ZCL A;  5KA9 A;  1GG4 A;  1E0D A;  5K22 A;  1UAG A;  4D3R A;  1Q6M A;  1NO6 A;  2PA5 A;  3AWE A;  5AWX A;  5KA2 A;  4H1O A;  1XRI A;  1SUG A;  4C12 A;  4GRZ A;  1OES A;  3S3H A;  2CNE A;  2F6V A;  2FH7 A;  4GE2 A;  2SHP A;  2VOR A;  1YPT A;  2B49 A;  1PTT A;  1U25 A;  1JF7 A;  3A5J A;  3ZM3 A;  4ERC A;  2F6W A;  1YWF A;  1I57 A;  1C86 A;  2XPC A;  5K23 A;  3ZM0 A;  1XM2 A;  3QCL A;  1E8C A;  2NZ6 A;  2QDP A;  3F9A A;  4ZN5 A;  3ZM6 A;  1C85 A;  4GFU A;  2CM2 A;  2ZN7 A;  2UUO A;  2VTE A;  2I4E A;  1JBW A;  2QBP A;  2HB1 A;  1OET A;  2PQ5 A;  5EHP A;  3CWE A;  1I9S A;  4J51 A;  3ZM2 A;  4ZIY A;  2M3V A;  3EU0 A;  4B04 A;  3ZM5 A;  3RZ2 A;  2VEX A;  2GCB A;  5BUG A;  2F71 A;  4QAH A;  3A5K A;  1GQY A;  3QCH A;  2I6M A;  1YFO A;  5BX1 A;  2JJD A;  3F41 A;  1C88 A;  2QEP A;  3D1Q A;  3QCN A;  3MOW A;  1BZC A;  1NNY A;  2NT7 A;  2VOS A;  1OEV A;  2I4H A;  2HXP A;  1G1F A;  2AZR A;  2H4G A;  1C83 A;  1OHD A;  5IBS A;  5K9V A;  1FPZ A;  5KA4 A;  3I36 A;  4ZRT A;  2GP0 A;  1ZC0 A;  2H04 A;  2BGE A;  3OMH A;  4NWF A;  1EEO A;  2QCT A;  4RH9 A;  2CFV A;  3N0A A;  5KA0 A;  1AAX A;  1FQ1 A;  1G4U S;  3QCK A;  4RI5 A;  1O5Z A;  3CM3 A;  2UAG A;  4KI9 A;  1ONY A;  1J6U A;  2PSZ A;  1QZ0 A;  3D9C A;  4HJP A;  2Y68 A;  5KAD A;  2F6Z A;  5KAA A;  3F99 A;  2GJT A;  4OHE A;  2Y66 A;  2P6X A;  1YZ4 A;  1JBV A;  2PT0 A;  2QCJ A;  1I9T A;  5K25 A;  3V0H A;  4KYR A;  4RI4 A;  2CM3 A;  2H4V A;  3S4E A;  1G7F A;  1NL9 A;  3HN7 A;  4QDI A;  2WTZ A;  3NME A;  1NWL A;  1NWE A;  2HVL A;  4WU3 A;  3I7Z A;  4WTY A;  3LK7 A;  3RGO A;  4YAA A;  4HV4 A;  1VHR A;  1V3A A;  3I80 A;  3D42 A;  1BZJ A;  2I3R A;  2HY3 A;  2HC2 A;  2IMG A;  3LJ8 A;  3PYZ A;  2NV5 A;  2F6F A;  4R0T A;  2FJN A;  3QCZ A;  2C46 A;  2Y2F A;  1KAV A;  3QCI A;  2JFF A;  1OHC A;  2F70 A;  2J17 A;  5K9W A;  4QUM A;  1C87 A;  1P3D A;  2C7S A; 
#chains in the Genus database with same CATH homology
 3AWF A;  4GS0 A;  2P4D A;  3BLU A;  2OUD A;  4JMJ A;  1QXK A;  2WGP A;  4Z6B A;  2CNF A;  4NND A;  3S3E A;  4GWF A;  2CNG A;  4JBC A;  2Q47 A;  2A3K A;  2B4O A;  2DXP A;  4OHD A;  2FJM A;  3QCG A;  3ZMQ A;  4GRY A;  4JNB A;  3S4O A;  3SME A;  4DGX A;  1PTV A;  2Q05 A;  2F46 A;  3H2X A;  3EZZ A;  5KA3 A;  3O4U A;  3V0I A;  2H02 A;  2I6J A;  1PXH A;  1WCH A;  1XBO A;  1NZ7 A;  3GXG A;  3ZV2 A;  3RGQ A;  5KAB A;  2QBQ A;  1KAK A;  2VEU A;  3S3K A;  1YGR A;  1ZZW A;  4BPC A;  3M4U A;  3V0E A;  1ONZ A;  1RXD A;  4QBE A;  2I6P A;  1EEN A;  3QCD A;  1G1G A;  5BZX A;  4RHG A;  1G7G A;  2BGD A;  1BZH A;  1ECV A;  4OHH A;  3QCE A;  3BLT A;  2YDU A;  2CNI A;  2B3O A;  1C84 A;  4ICZ A;  4D3Q A;  2HNQ A;  4TVV A;  5KA1 A;  2HCM A;  3ZM1 A;  2CMB A;  4Y2E A;  5MMZ B;  1OEO X;  4JMK A;  4WOH A;  3V0J A;  4D3P A;  5J8R A;  3B7O A;  3D1O A;  1G4W R;  3PS5 A;  2G6Z A;  1T49 A;  3OLR A;  2ZMM A;  3U96 A;  1YTW A;  4RDD A;  5HDE A;  1MKP A;  2B4P A;  2PI7 A;  1U26 A;  1PTU A;  2G59 A;  3BM8 A;  1Q6J A;  1T48 A;  1Q6P A;  4R30 A;  2CM8 A;  4KYQ A;  4MBB A;  1XXP A;  3QCC A;  1LAR A;  2H4K A;  1G1H A;  2BZL A;  2J16 B;  2R0B A;  1PTY A;  4DGP A;  1JLN A;  1LYV A;  2CMA A;  4BJO A;  3V0F A;  2CMC A;  3EAX A;  3O4S A;  4RKK A;  2GWO A;  3D1H A;  1R6H A;  1J4X A;  1Q6N A;  1OEU A;  1PH0 A;  2NTA A;  2QBR A;  3QKQ A;  2B4U A;  1YN9 A;  1YGU A;  5I6V A;  2NLK A;  2QBS A;  1YTN A;  5LXQ B;  4QUN A;  2B4S A;  2B07 A;  5KA7 A;  4GFV A;  4QBW A;  2I3U A;  1LQF A;  1T4J A;  1GFY A;  4I8N A;  5IBM A;  4NYH A;  3O5X A;  1Q1M A;  2OC3 A;  1Q6T A;  3EB1 A;  2VEW A;  1PA9 A;  4GE5 A;  2QDC A;  4YR8 B;  1OEM X;  2BIJ A;  1RPM A;  2CM7 A;  2I6I A;  3QCF A;  1P15 A;  2AHS A;  3S3F A;  3EMU A;  1X24 A;  2E0T A;  1Q6S A;  5K24 A;  2CJZ A;  1GWZ A;  3GXH A;  5KAC A;  4NWG A;  4H34 A;  1ZCK A;  2ESB A;  2A8B A;  1D5R A;  1PYN A;  3BRH A;  4NX8 A;  3D44 A;  4AZ1 A;  4GE6 A;  3O4T A;  2VEY A;  3RO1 A;  4OHI A;  2PBN A;  1OHE A;  2I5X A;  4PYH A;  4R0S A;  5KA8 A;  2MBC A;  2HC1 A;  3QCB A;  3MOZ A;  3QKP A;  3QCM A;  3AWG A;  2I4G A;  1WRM A;  2RF6 A;  4ZI4 A;  2I1Y A;  3F81 A;  1PA1 A;  4PVG A;  3SR9 A;  2J16 A;  2Y96 A;  1YTS A;  2H03 A;  2CNH A;  1U24 A;  3QCJ A;  5M43 A;  3F9B A;  2F6Y A;  1L8G A;  2I6O A;  1WAX A;  2NT2 A;  2I42 A;  1FPR A;  4IKC A;  4HJQ A;  4S0G A;  2VEV A;  3O3L A;  1XXV A;  5EHR A;  2HNP A;  4HRF A;  1A5Y A;  2OOQ A;  2OZ5 A;  4Y14 A;  4WU2 A;  4QAP A;  3MMJ A;  5BZZ A;  5GTJ A;  3V0G A;  4RH5 A;  3ZMP A;  3V0D A;  1M3G A;  2QDM A;  1L8K A;  4OHL A;  2F6T A;  2I75 A;  2BV5 A;  1ZCL A;  5KA9 A;  5K22 A;  4D3R A;  1Q6M A;  1NO6 A;  2PA5 A;  3AWE A;  5AWX A;  5KA2 A;  4H1O A;  1XRI A;  1SUG A;  4GRZ A;  1OES A;  3S3H A;  2CNE A;  2F6V A;  2FH7 A;  4GE2 A;  2SHP A;  1YPT A;  2B49 A;  1PTT A;  1U25 A;  1JF7 A;  3A5J A;  3ZM3 A;  4ERC A;  2F6W A;  1YWF A;  1I57 A;  1C86 A;  5K23 A;  3ZM0 A;  1XM2 A;  3QCL A;  2NZ6 A;  2QDP A;  3F9A A;  4ZN5 A;  1C85 A;  4GFU A;  2CM2 A;  2ZN7 A;  2I4E A;  2QBP A;  2HB1 A;  1OET A;  2PQ5 A;  5EHP A;  3CWE A;  1I9S A;  4J51 A;  3ZM2 A;  2M3V A;  3EU0 A;  4B04 A;  3RZ2 A;  2VEX A;  5BUG A;  2F71 A;  4QAH A;  3A5K A;  3QCH A;  2I6M A;  1YFO A;  5BX1 A;  2JJD A;  3F41 A;  1C88 A;  3QCN A;  3D1Q A;  2QEP A;  3MOW A;  1BZC A;  1NNY A;  2NT7 A;  1OEV A;  2I4H A;  2HXP A;  1G1F A;  2AZR A;  2H4G A;  1C83 A;  1OHD A;  5IBS A;  5K9V A;  1FPZ A;  5KA4 A;  3I36 A;  4ZRT A;  2GP0 A;  1ZC0 A;  2H04 A;  2BGE A;  3OMH A;  4NWF A;  1EEO A;  2QCT A;  4RH9 A;  2CFV A;  3N0A A;  5KA0 A;  1AAX A;  1FQ1 A;  1G4U S;  3QCK A;  4RI5 A;  3CM3 A;  4KI9 A;  1ONY A;  2PSZ A;  1QZ0 A;  3D9C A;  4HJP A;  5KAD A;  2F6Z A;  5KAA A;  3F99 A;  2GJT A;  4OHE A;  2P6X A;  1YZ4 A;  2PT0 A;  2QCJ A;  1I9T A;  5K25 A;  3V0H A;  4KYR A;  4RI4 A;  2CM3 A;  2H4V A;  3S4E A;  1G7F A;  1NL9 A;  3NME A;  1NWL A;  1NWE A;  2HVL A;  4WU3 A;  3I7Z A;  4WTY A;  3RGO A;  4YAA A;  1VHR A;  1V3A A;  3I80 A;  3D42 A;  1BZJ A;  2I3R A;  2HY3 A;  2HC2 A;  2IMG A;  3LJ8 A;  2NV5 A;  2F6F A;  4R0T A;  2FJN A;  2C46 A;  2Y2F A;  1KAV A;  3QCI A;  1OHC A;  2F70 A;  2J17 A;  5K9W A;  4QUM A;  1C87 A;  2C7S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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