2VEXA

Crystal strucutre of protein tyrosine phosphatase 1b in complex with an isothiazolidinone-containing inhibitor
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
297
structure length
297
Chain Sequence
MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
total genus 100
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2007-10-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2vexA00
4GWFA 4RHGA 3QCCA 3O4SA 2CFVA 4QUNA 4TVVA 2VEYA 2I6OA 2HC2A 1PTTA 1I9SA 4KYRA 5KA0A 2ZN7A 1U26A 2CMCA 1XBOA 3QKQA 2C7SA 2CNEA 4RI4A 3D9CA 1P15A 1RPMA 3OLRA 3V0FA 2HXPA 5KA9A 2NZ6A 3I36A 2IMGA 1G1FA 3I80A 1PH0A 2PBNA 4GRZA 1NO6A 4NNDA 4GFVA 2GJTA 1LYVA 2C46A 4KYQA 4IKCA 2H04A 4HJQA 4WTYA 2HNPA 2GWOA 2I6PA 1GFYA 2QDCA 2M3VA 3QCKA 5IBSA 1Q6JA 3RGOA 1ONYA 2A8BA 3SR9A 4DGXA 5KA8A 3S3KA 4Z6BA 1ZCKA 2FJMA 2H03A 3CWEA 2SHPA 2NV5A 3BLTA 2F6VA 4Y2EA 5AWXA 1T4JA 3N0AA 1C83A 3BLUA 4OHDA 4NX8A 3ZM3A 3QCJA 3QCLA 1Q6TA 1J4XA 2NTAA 2H4KA 2YDUA 4WU2A 1QXKA 2F70A 2B3OA 3S3FA 1JF7A 2I6JA 4GFUA 5KA2A 3V0HA 1EENA 4BPCA 1LARA 2B4OA 3QCBA 4RH9A 5K25A 2J16A 1G1HA 1PYNA 3S4OA 3B7OA 3QCEA 3MOWA 4OHEA 5KA1A 2I5XA 5KA7A 4YR8B 2QBRA 4R0TA 3RZ2A 1Q6NA 1SUGA 2I6IA 1FQ1A 3QCHA 4D3PA 3GXHA 3S3EA 3QCDA 3AWGA 3F9AA 1VHRA 3ZM0A 2HNQA 2CM2A 3EAXA 3D1HA 4B04A 3I7ZA 2CM8A 2QBQA 5M43A 4QUMA 3O3LA 3U96A 3RO1A 1YGUA 1FPZA 4QAPA 2GP0A 2NLKA 4HRFA 1G4WR 1EEOA 1BZJA 3EU0A 1ONZA 4J51A 1ECVA 4GE6A 4OHLA 5KADA 2J16B 1YTSA 1WAXA 1Q6PA 1JLNA 4JMJA 2I42A 2G59A 3BM8A 2VEVA 3RGQA 1PTUA 2QBPA 4RI5A 4RKKA 2H02A 2H4VA 4NWGA 2BIJA 3F9BA 5IBMA 2B4PA 1OEVA 5BX1A 3V0DA 1OEOX 3H2XA 5LXQB 3AWFA 4ICZA 3D44A 1C84A 1YFOA 3ZV2A 5MMZB 5GTJA 1KAVA 2I4HA 5EHRA 5K23A 2Y2FA 4WU3A 4WOHA 2F6WA 2DXPA 4AZ1A 3O4TA 3CM3A 4OHIA 1L8GA 1NZ7A 2F6YA 1BZCA 2QDMA 2QBSA 2A3KA 3LJ8A 2Q47A 3S3HA 3EMUA 1X24A 2QDPA 4PYHA 5BUGA 2BV5A 3V0EA 1U25A 4ZI4A 4R30A 4RDDA 1T48A 2QCTA 2HVLA 1XXPA 4QBEA 1KAKA 3A5KA 2MBCA 3AWEA 2F71A 3QCMA 5I6VA 2HC1A 3EB1A 1RXDA 4QBWA 2E0TA 2VEXA 3V0IA 2CNHA 2VEWA 1MKPA 1NWLA 3NMEA 4I8NA 5K22A 2CNIA 2I1YA 2CNFA 2B4SA 2Y96A 1C85A 3QCIA 1AAXA 1NNYA 1YTNA 1PA1A 2NT2A 4GRYA 1I57A 2RF6A 4S0GA 3F99A 2I4GA 1A5YA 2P4DA 2PQ5A 5BZZA 2CJZA 1Q1MA 2FH7A 3ZM1A 1WCHA 5EHPA 3D1OA 2PI7A 3ZMQA 2ZMMA 3ZMPA 3O4UA 2G6ZA 4RH5A 5KABA 1YWFA 5KACA 2BZLA 1XRIA 4KI9A 2CM7A 1G4US 4MBBA 4Y14A 2F6ZA 3M4UA 5K9WA 4ZRTA 1YTWA 2CM3A 1YPTA 2H4GA 2OC3A 4HJPA 3QCFA 3BRHA 2I75A 5KAAA 3QCNA 2VEUA 2I3UA 3A5JA 4JBCA 3V0JA 3MMJA 1OHCA 1T49A 2R0BA 4QAHA 2BGEA 1NWEA 2I4EA 5HDEA 1L8KA 1GWZA 4D3RA 1YN9A 2AHSA 1D5RA 2JJDA 3PS5A 1PTYA 2B07A 2QCJA 3OMHA 2FJNA 1FPRA 1OEMX 1BZHA 4GE2A 1R6HA 1G1GA 2ESBA 1YGRA 1OHEA 4JMKA 3F41A 2PSZA 1G7FA 1XM2A 1ZZWA 1OETA 4GS0A 3ZM2A 2B49A 1PXHA 1XXVA 2CNGA 5K24A 5KA4A 2F6TA 3F81A 1NL9A 4ERCA 1OEUA 4OHHA 1Q6SA 5J8RA 1WRMA 3MOZA 2PT0A 1V3AA 2OOQA 2PA5A 3EZZA 1Q6MA 2WGPA 2HY3A 2NT7A 2BGDA 2AZRA 4H1OA 1ZC0A 2J17A 1PA9A 3QCGA 2CMAA 4BJOA 1G7GA 4JNBA 3D42A 3GXGA 1PTVA 1U24A 5KA3A 2QEPA 5K9VA 4H34A 2I6MA 3V0GA 2HCMA 2OZ5A 3O5XA 4PVGA 2F46A 4ZN5A 1LQFA 1OESA 1I9TA 2HB1A 4GE5A 4D3QA 2Q05A 2I3RA 3S4EA 1ZCLA 4DGPA 1C87A 1C88A 1QZ0A 2OUDA 3D1QA 5BZXA 4NYHA 1M3GA 2B4UA 1YZ4A 3QKPA 4NWFA 2F6FA 2P6XA 1OHDA 1C86A 4R0SA 2CMBA 3SMEA 4YAAA
chains in the Genus database with same CATH superfamily
4GWFA 4RHGA 3QCCA 3O4SA 2CFVA 4QUNA 4TVVA 2VEYA 2I6OA 2HC2A 1PTTA 1I9SA 4KYRA 5KA0A 2ZN7A 1U26A 4CVMA 2CMCA 1XBOA 3QKQA 2C7SA 2CNEA 4RI4A 3D9CA 4UAGA 1P15A 1RPMA 4BUBA 3OLRA 3V0FA 2HXPA 2UAGA 5KA9A 2NZ6A 3I36A 2IMGA 1G1FA 3I80A 1PH0A 2PBNA 4GRZA 1NO6A 4NNDA 4GFVA 2GJTA 1LYVA 2C46A 4KYQA 4IKCA 2H04A 4HJQA 4WTYA 2HNPA 2GWOA 2I6PA 2JFHA 1GFYA 2AM2A 2QDCA 2M3VA 3QCKA 4HV4A 1GQQA 5IBSA 1Q6JA 3RGOA 1P31A 1ONYA 2A8BA 3SR9A 4DGXA 5KA8A 3S3KA 4Z6BA 1ZCKA 1JBVA 2FJMA 2H03A 3CWEA 2SHPA 2NV5A 1GQYA 3BLTA 2F6VA 4Y2EA 5AWXA 1T4JA 3N0AA 1C83A 3BLUA 4OHDA 4NX8A 3ZM3A 3QCJA 3QCLA 1Q6TA 1J4XA 2NTAA 2H4KA 2YDUA 4WU2A 1QXKA 1GG4A 2F70A 2B3OA 3S3FA 1JF7A 1J6UA 2I6JA 4GFUA 5KA2A 3V0HA 1EENA 4BPCA 1LARA 2XJAA 2B4OA 2GC6A 2XPCA 3QCBA 4RH9A 5K25A 2J16A 1G1HA 1PYNA 3S4OA 3B7OA 2UUOA 3QCEA 3MOWA 4OHEA 5KA1A 2VORA 2I5XA 5KA7A 4YR8B 2QBRA 4R0TA 3RZ2A 1Q6NA 1SUGA 2JFFA 2I6IA 1FQ1A 3QCHA 4C13A 4D3PA 1E8CA 3GXHA 2VTDA 3S3EA 3QCDA 3AWGA 3F9AA 1VHRA 3ZM0A 2HNQA 2CM2A 3EAXA 3D1HA 4B04A 3I7ZA 2CM8A 2QBQA 5M43A 4QUMA 3O3LA 3U96A 1EEHA 3RO1A 1YGUA 1FPZA 4QAPA 2GP0A 4QDIA 2NLKA 4HRFA 3ZL8A 2VTEA 1G4WR 1EEOA 5A5EA 1BZJA 2JFGA 2GCAA 3EU0A 1ONZA 4J51A 1ECVA 4GE6A 4OHLA 5KADA 2J16B 1YTSA 4CVLA 1WAXA 1Q6PA 1JLNA 4JMJA 2I42A 1W78A 2G59A 3BM8A 2VEVA 3RGQA 1PTUA 2QBPA 4RI5A 4RKKA 2WTZA 2H02A 2H4VA 4NWGA 2BIJA 3F9BA 3ZM5A 5IBMA 2B4PA 1OEVA 5BX1A 3V0DA 1OEOX 3H2XA 5LXQB 3AWFA 4ICZA 3D44A 1C84A 1YFOA 3ZV2A 5MMZB 5GTJA 1KAVA 2I4HA 5EHRA 5K23A 2Y2FA 4WU3A 4WOHA 2X5OA 2F6WA 2GCBA 2DXPA 4AZ1A 3NRSA 3O4TA 3CM3A 4OHIA 1L8GA 1NZ7A 2F6YA 1BZCA 2QDMA 2QBSA 2A3KA 1W7KA 3LJ8A 3HN7A 2Q47A 3S3HA 3EMUA 1X24A 2QDPA 4C12A 4PYHA 5BUGA 2BV5A 3V0EA 1U25A 4ZI4A 2Y66A 4R30A 4RDDA 1T48A 2QCTA 2HVLA 3UAGA 1XXPA 4QBEA 1KAKA 3A5KA 2MBCA 3AWEA 2F71A 3QCMA 5I6VA 2HC1A 3EB1A 1RXDA 4QBWA 2E0TA 2VEXA 5A5FA 3V0IA 2CNHA 2VEWA 1MKPA 1NWLA 3NMEA 4I8NA 2VOSA 2Y1OA 5K22A 2CNIA 2I1YA 2CNFA 2B4SA 2Y96A 1C85A 1P3DA 3QCIA 1AAXA 1NNYA 1YTNA 1PA1A 2NT2A 4GRYA 4ZIYA 1I57A 2RF6A 4S0GA 3F99A 2I4GA 1A5YA 2P4DA 2PQ5A 5BZZA 2CJZA 1Q1MA 2FH7A 3ZM1A 1WCHA 3MVNA 5EHPA 3D1OA 2PI7A 3ZMQA 2ZMMA 3ZMPA 3O4UA 2G6ZA 4RH5A 5KABA 1YWFA 5KACA 2BZLA 1XRIA 4KI9A 2CM7A 1G4US 4MBBA 4Y14A 2F6ZA 3M4UA 3N2AA 5K9WA 4ZRTA 1YTWA 2CM3A 1YPTA 2H4GA 2OC3A 4HJPA 3QCFA 3BRHA 2I75A 5KAAA 1FGSA 3QCNA 2VEUA 3ZM6A 2I3UA 3A5JA 4JBCA 3V0JA 3MMJA 1OHCA 1T49A 2R0BA 4QAHA 2BGEA 1NWEA 2GC5A 2I4EA 2WJPA 5HDEA 1L8KA 3QCZA 1GWZA 4D3RA 1YN9A 2AHSA 1D5RA 2JJDA 1PTYA 2B07A 2QCJA 3PS5A 3OMHA 2FJNA 1FPRA 1OEMX 1BZHA 4GE2A 1R6HA 1G1GA 1O5ZA 2ESBA 1YGRA 1OHEA 4JMKA 3F41A 2PSZA 1G7FA 1XM2A 1ZZWA 1OETA 4GS0A 3ZM2A 2B49A 2AM1A 1PXHA 1XXVA 2CNGA 5K24A 5KA4A 2F6TA 4CVKA 3F81A 1NL9A 4QF5A 4ERCA 1OEUA 1JBWA 4OHHA 1Q6SA 5J8RA 2Y67A 1WRMA 3MOZA 2PT0A 1V3AA 2OOQA 2PA5A 3EZZA 1Q6MA 2WGPA 2HY3A 2NT7A 2BGDA 2AZRA 4H1OA 3LK7A 1ZC0A 2J17A 1PA9A 3QCGA 2CMAA 4BJOA 1G7GA 4JNBA 1E0DA 3D42A 3GXGA 3PYZA 1PTVA 1U24A 5KA3A 2Y68A 2QEPA 1UAGA 5K9VA 4H34A 2I6MA 3V0GA 2HCMA 2OZ5A 3O5XA 4PVGA 2F46A 4ZN5A 1LQFA 1OESA 1I9TA 2HB1A 4GE5A 4D3QA 2F00A 2Q05A 2I3RA 3S4EA 4BUCA 1ZCLA 4DGPA 1C87A 1C88A 1QZ0A 2OUDA 3D1QA 5BZXA 4NYHA 1M3GA 2B4UA 1YZ4A 3QKPA 4NWFA 2F6FA 2P6XA 1OHDA 1C86A 4R0SA 2CMBA 3SMEA 2UUPA 4YAAA
chains in the Genus database with same CATH topology
4GWFA 4RHGA 3QCCA 3O4SA 2CFVA 4QUNA 4TVVA 2VEYA 2I6OA 2HC2A 1PTTA 1I9SA 4KYRA 5KA0A 2ZN7A 1U26A 2CMCA 1XBOA 3QKQA 2C7SA 2CNEA 4RI4A 3D9CA 1P15A 1RPMA 3OLRA 3V0FA 2HXPA 5KA9A 2NZ6A 3I36A 2IMGA 1G1FA 3I80A 1PH0A 2PBNA 4GRZA 1NO6A 4NNDA 4GFVA 2GJTA 1LYVA 2C46A 4KYQA 4IKCA 2H04A 4HJQA 4WTYA 2HNPA 2GWOA 2I6PA 1GFYA 2QDCA 2M3VA 3QCKA 5IBSA 1Q6JA 3RGOA 1ONYA 2A8BA 3SR9A 4DGXA 5KA8A 3S3KA 4Z6BA 1ZCKA 2FJMA 2H03A 3CWEA 2SHPA 2NV5A 3BLTA 2F6VA 4Y2EA 5AWXA 1T4JA 3N0AA 1C83A 3BLUA 4OHDA 4NX8A 3ZM3A 3QCJA 3QCLA 1Q6TA 1J4XA 2NTAA 2H4KA 2YDUA 4WU2A 1QXKA 2F70A 2B3OA 3S3FA 1JF7A 2I6JA 4GFUA 5KA2A 3V0HA 1EENA 4BPCA 1LARA 2B4OA 3QCBA 4RH9A 5K25A 2J16A 1G1HA 1PYNA 3S4OA 3B7OA 3QCEA 3MOWA 4OHEA 5KA1A 2I5XA 5KA7A 4YR8B 2QBRA 4R0TA 3RZ2A 1Q6NA 1SUGA 2I6IA 1FQ1A 3QCHA 4D3PA 3GXHA 3S3EA 3QCDA 3AWGA 3F9AA 1VHRA 3ZM0A 2HNQA 2CM2A 3EAXA 3D1HA 4B04A 3I7ZA 2CM8A 2QBQA 5M43A 4QUMA 3O3LA 3U96A 3RO1A 1YGUA 1FPZA 4QAPA 2GP0A 2NLKA 4HRFA 1G4WR 1EEOA 1BZJA 3EU0A 1ONZA 4J51A 1ECVA 4GE6A 4OHLA 5KADA 2J16B 1YTSA 1WAXA 1Q6PA 1JLNA 4JMJA 2I42A 2G59A 3BM8A 2VEVA 3RGQA 1PTUA 2QBPA 4RI5A 4RKKA 2H02A 2H4VA 4NWGA 2BIJA 3F9BA 5IBMA 2B4PA 1OEVA 5BX1A 3V0DA 1OEOX 3H2XA 5LXQB 3AWFA 4ICZA 3D44A 1C84A 1YFOA 3ZV2A 5MMZB 5GTJA 1KAVA 2I4HA 5EHRA 5K23A 2Y2FA 4WU3A 4WOHA 2F6WA 2DXPA 4AZ1A 3O4TA 3CM3A 4OHIA 1L8GA 1NZ7A 2F6YA 1BZCA 2QDMA 2QBSA 2A3KA 3LJ8A 2Q47A 3S3HA 3EMUA 1X24A 2QDPA 4PYHA 5BUGA 2BV5A 3V0EA 1U25A 4ZI4A 4R30A 4RDDA 1T48A 2QCTA 2HVLA 1XXPA 4QBEA 1KAKA 3A5KA 2MBCA 3AWEA 2F71A 3QCMA 5I6VA 2HC1A 3EB1A 1RXDA 4QBWA 2E0TA 2VEXA 3V0IA 2CNHA 2VEWA 1MKPA 1NWLA 3NMEA 4I8NA 5K22A 2CNIA 2I1YA 2CNFA 2B4SA 2Y96A 1C85A 3QCIA 1AAXA 1NNYA 1YTNA 1PA1A 2NT2A 4GRYA 1I57A 2RF6A 4S0GA 3F99A 2I4GA 1A5YA 2P4DA 2PQ5A 5BZZA 2CJZA 1Q1MA 2FH7A 3ZM1A 1WCHA 5EHPA 3D1OA 2PI7A 3ZMQA 2ZMMA 3ZMPA 3O4UA 2G6ZA 4RH5A 5KABA 1YWFA 5KACA 2BZLA 1XRIA 4KI9A 2CM7A 1G4US 4MBBA 4Y14A 2F6ZA 3M4UA 5K9WA 4ZRTA 1YTWA 2CM3A 1YPTA 2H4GA 2OC3A 4HJPA 3QCFA 3BRHA 2I75A 5KAAA 3QCNA 2VEUA 2I3UA 3A5JA 4JBCA 3V0JA 3MMJA 1OHCA 1T49A 2R0BA 4QAHA 2BGEA 1NWEA 2I4EA 5HDEA 1L8KA 1GWZA 4D3RA 1YN9A 2AHSA 1D5RA 2JJDA 3PS5A 1PTYA 2B07A 2QCJA 3OMHA 2FJNA 1FPRA 1OEMX 1BZHA 4GE2A 1R6HA 1G1GA 2ESBA 1YGRA 1OHEA 4JMKA 3F41A 2PSZA 1G7FA 1XM2A 1ZZWA 1OETA 4GS0A 3ZM2A 2B49A 1PXHA 1XXVA 2CNGA 5K24A 5KA4A 2F6TA 3F81A 1NL9A 4ERCA 1OEUA 4OHHA 1Q6SA 5J8RA 1WRMA 3MOZA 2PT0A 1V3AA 2OOQA 2PA5A 3EZZA 1Q6MA 2WGPA 2HY3A 2NT7A 2BGDA 2AZRA 4H1OA 1ZC0A 2J17A 1PA9A 3QCGA 2CMAA 4BJOA 1G7GA 4JNBA 3D42A 3GXGA 1PTVA 1U24A 5KA3A 2QEPA 5K9VA 4H34A 2I6MA 3V0GA 2HCMA 2OZ5A 3O5XA 4PVGA 2F46A 4ZN5A 1LQFA 1OESA 1I9TA 2HB1A 4GE5A 4D3QA 2Q05A 2I3RA 3S4EA 1ZCLA 4DGPA 1C87A 1C88A 1QZ0A 2OUDA 3D1QA 5BZXA 4NYHA 1M3GA 2B4UA 1YZ4A 3QKPA 4NWFA 2F6FA 2P6XA 1OHDA 1C86A 4R0SA 2CMBA 3SMEA 4YAAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GWF A;  4RHG A;  3QCC A;  3O4S A;  2CFV A;  4QUN A;  4TVV A;  2VEY A;  2I6O A;  2HC2 A;  1PTT A;  1I9S A;  4KYR A;  5KA0 A;  2ZN7 A;  1U26 A;  2CMC A;  1XBO A;  3QKQ A;  2C7S A;  2CNE A;  4RI4 A;  3D9C A;  1P15 A;  1RPM A;  3OLR A;  3V0F A;  2HXP A;  5KA9 A;  2NZ6 A;  3I36 A;  2IMG A;  1G1F A;  3I80 A;  1PH0 A;  2PBN A;  4GRZ A;  1NO6 A;  4NND A;  4GFV A;  2GJT A;  1LYV A;  2C46 A;  4KYQ A;  4IKC A;  2H04 A;  4HJQ A;  4WTY A;  2HNP A;  2GWO A;  2I6P A;  1GFY A;  2QDC A;  2M3V A;  3QCK A;  5IBS A;  1Q6J A;  3RGO A;  1ONY A;  2A8B A;  3SR9 A;  4DGX A;  5KA8 A;  3S3K A;  4Z6B A;  1ZCK A;  2FJM A;  2H03 A;  3CWE A;  2SHP A;  2NV5 A;  3BLT A;  2F6V A;  4Y2E A;  5AWX A;  1T4J A;  3N0A A;  1C83 A;  3BLU A;  4OHD A;  4NX8 A;  3ZM3 A;  3QCJ A;  3QCL A;  1Q6T A;  1J4X A;  2NTA A;  2H4K A;  2YDU A;  4WU2 A;  1QXK A;  2F70 A;  2B3O A;  3S3F A;  1JF7 A;  2I6J A;  4GFU A;  5KA2 A;  3V0H A;  1EEN A;  4BPC A;  1LAR A;  2B4O A;  3QCB A;  4RH9 A;  5K25 A;  2J16 A;  1G1H A;  1PYN A;  3S4O A;  3B7O A;  3QCE A;  3MOW A;  4OHE A;  5KA1 A;  2I5X A;  5KA7 A;  4YR8 B;  2QBR A;  4R0T A;  3RZ2 A;  1Q6N A;  1SUG A;  2I6I A;  1FQ1 A;  3QCH A;  4D3P A;  3GXH A;  3S3E A;  3QCD A;  3AWG A;  3F9A A;  1VHR A;  3ZM0 A;  2HNQ A;  2CM2 A;  3EAX A;  3D1H A;  4B04 A;  3I7Z A;  2CM8 A;  2QBQ A;  5M43 A;  4QUM A;  3O3L A;  3U96 A;  3RO1 A;  1YGU A;  1FPZ A;  4QAP A;  2GP0 A;  2NLK A;  4HRF A;  1G4W R;  1EEO A;  1BZJ A;  3EU0 A;  1ONZ A;  4J51 A;  1ECV A;  4GE6 A;  4OHL A;  5KAD A;  2J16 B;  1YTS A;  1WAX A;  1Q6P A;  1JLN A;  4JMJ A;  2I42 A;  2G59 A;  3BM8 A;  2VEV A;  3RGQ A;  1PTU A;  2QBP A;  4RI5 A;  4RKK A;  2H02 A;  2H4V A;  4NWG A;  2BIJ A;  3F9B A;  5IBM A;  2B4P A;  1OEV A;  5BX1 A;  3V0D A;  1OEO X;  3H2X A;  5LXQ B;  3AWF A;  4ICZ A;  3D44 A;  1C84 A;  1YFO A;  3ZV2 A;  5MMZ B;  5GTJ A;  1KAV A;  2I4H A;  5EHR A;  5K23 A;  2Y2F A;  4WU3 A;  4WOH A;  2F6W A;  2DXP A;  4AZ1 A;  3O4T A;  3CM3 A;  4OHI A;  1L8G A;  1NZ7 A;  2F6Y A;  1BZC A;  2QDM A;  2QBS A;  2A3K A;  3LJ8 A;  2Q47 A;  3S3H A;  3EMU A;  1X24 A;  2QDP A;  4PYH A;  5BUG A;  2BV5 A;  3V0E A;  1U25 A;  4ZI4 A;  4R30 A;  4RDD A;  1T48 A;  2QCT A;  2HVL A;  1XXP A;  4QBE A;  1KAK A;  3A5K A;  2MBC A;  3AWE A;  2F71 A;  3QCM A;  5I6V A;  2HC1 A;  3EB1 A;  1RXD A;  4QBW A;  2E0T A;  2VEX A;  3V0I A;  2CNH A;  2VEW A;  1MKP A;  1NWL A;  3NME A;  4I8N A;  5K22 A;  2CNI A;  2I1Y A;  2CNF A;  2B4S A;  2Y96 A;  1C85 A;  3QCI A;  1AAX A;  1NNY A;  1YTN A;  1PA1 A;  2NT2 A;  4GRY A;  1I57 A;  2RF6 A;  4S0G A;  3F99 A;  2I4G A;  1A5Y A;  2P4D A;  2PQ5 A;  5BZZ A;  2CJZ A;  1Q1M A;  2FH7 A;  3ZM1 A;  1WCH A;  5EHP A;  3D1O A;  2PI7 A;  3ZMQ A;  2ZMM A;  3ZMP A;  3O4U A;  2G6Z A;  4RH5 A;  5KAB A;  1YWF A;  5KAC A;  2BZL A;  1XRI A;  4KI9 A;  2CM7 A;  1G4U S;  4MBB A;  4Y14 A;  2F6Z A;  3M4U A;  5K9W A;  4ZRT A;  1YTW A;  2CM3 A;  1YPT A;  2H4G A;  2OC3 A;  4HJP A;  3QCF A;  3BRH A;  2I75 A;  5KAA A;  3QCN A;  2VEU A;  2I3U A;  3A5J A;  4JBC A;  3V0J A;  3MMJ A;  1OHC A;  1T49 A;  2R0B A;  4QAH A;  2BGE A;  1NWE A;  2I4E A;  5HDE A;  1L8K A;  1GWZ A;  4D3R A;  1YN9 A;  2AHS A;  1D5R A;  2JJD A;  3PS5 A;  1PTY A;  2B07 A;  2QCJ A;  3OMH A;  2FJN A;  1FPR A;  1OEM X;  1BZH A;  4GE2 A;  1R6H A;  1G1G A;  2ESB A;  1YGR A;  1OHE A;  4JMK A;  3F41 A;  2PSZ A;  1G7F A;  1XM2 A;  1ZZW A;  1OET A;  4GS0 A;  3ZM2 A;  2B49 A;  1PXH A;  1XXV A;  2CNG A;  5K24 A;  5KA4 A;  2F6T A;  3F81 A;  1NL9 A;  4ERC A;  1OEU A;  4OHH A;  1Q6S A;  5J8R A;  1WRM A;  3MOZ A;  2PT0 A;  1V3A A;  2OOQ A;  2PA5 A;  3EZZ A;  1Q6M A;  2WGP A;  2HY3 A;  2NT7 A;  2BGD A;  2AZR A;  4H1O A;  1ZC0 A;  2J17 A;  1PA9 A;  3QCG A;  2CMA A;  4BJO A;  1G7G A;  4JNB A;  3D42 A;  3GXG A;  1PTV A;  1U24 A;  5KA3 A;  2QEP A;  5K9V A;  4H34 A;  2I6M A;  3V0G A;  2HCM A;  2OZ5 A;  3O5X A;  4PVG A;  2F46 A;  4ZN5 A;  1LQF A;  1OES A;  1I9T A;  2HB1 A;  4GE5 A;  4D3Q A;  2Q05 A;  2I3R A;  3S4E A;  1ZCL A;  4DGP A;  1C87 A;  1C88 A;  1QZ0 A;  2OUD A;  3D1Q A;  5BZX A;  4NYH A;  1M3G A;  2B4U A;  1YZ4 A;  3QKP A;  4NWF A;  2F6F A;  2P6X A;  1OHD A;  1C86 A;  4R0S A;  2CMB A;  3SME A;  4YAA A; 
#chains in the Genus database with same CATH topology
 4GWF A;  4RHG A;  3QCC A;  3O4S A;  2CFV A;  4QUN A;  4TVV A;  2VEY A;  2I6O A;  2HC2 A;  1PTT A;  1I9S A;  4KYR A;  5KA0 A;  2ZN7 A;  1U26 A;  4CVM A;  2CMC A;  1XBO A;  3QKQ A;  2C7S A;  2CNE A;  4RI4 A;  3D9C A;  4UAG A;  1P15 A;  1RPM A;  4BUB A;  3OLR A;  3V0F A;  2HXP A;  2UAG A;  5KA9 A;  2NZ6 A;  3I36 A;  2IMG A;  1G1F A;  3I80 A;  1PH0 A;  2PBN A;  4GRZ A;  1NO6 A;  4NND A;  4GFV A;  2GJT A;  1LYV A;  2C46 A;  4KYQ A;  4IKC A;  2H04 A;  4HJQ A;  4WTY A;  2HNP A;  2GWO A;  2I6P A;  2JFH A;  1GFY A;  2AM2 A;  2QDC A;  2M3V A;  3QCK A;  4HV4 A;  1GQQ A;  5IBS A;  1Q6J A;  3RGO A;  1P31 A;  1ONY A;  2A8B A;  3SR9 A;  4DGX A;  5KA8 A;  3S3K A;  4Z6B A;  1ZCK A;  1JBV A;  2FJM A;  2H03 A;  3CWE A;  2SHP A;  2NV5 A;  1GQY A;  3BLT A;  2F6V A;  4Y2E A;  5AWX A;  1T4J A;  3N0A A;  1C83 A;  3BLU A;  4OHD A;  4NX8 A;  3ZM3 A;  3QCJ A;  3QCL A;  1Q6T A;  1J4X A;  2NTA A;  2H4K A;  2YDU A;  4WU2 A;  1QXK A;  1GG4 A;  2F70 A;  2B3O A;  3S3F A;  1JF7 A;  1J6U A;  2I6J A;  4GFU A;  5KA2 A;  3V0H A;  1EEN A;  4BPC A;  1LAR A;  2XJA A;  2B4O A;  2GC6 A;  2XPC A;  3QCB A;  4RH9 A;  5K25 A;  2J16 A;  1G1H A;  1PYN A;  3S4O A;  3B7O A;  2UUO A;  3QCE A;  3MOW A;  4OHE A;  5KA1 A;  2VOR A;  2I5X A;  5KA7 A;  4YR8 B;  2QBR A;  4R0T A;  3RZ2 A;  1Q6N A;  1SUG A;  2JFF A;  2I6I A;  1FQ1 A;  3QCH A;  4C13 A;  4D3P A;  1E8C A;  3GXH A;  2VTD A;  3S3E A;  3QCD A;  3AWG A;  3F9A A;  1VHR A;  3ZM0 A;  2HNQ A;  2CM2 A;  3EAX A;  3D1H A;  4B04 A;  3I7Z A;  2CM8 A;  2QBQ A;  5M43 A;  4QUM A;  3O3L A;  3U96 A;  1EEH A;  3RO1 A;  1YGU A;  1FPZ A;  4QAP A;  2GP0 A;  4QDI A;  2NLK A;  4HRF A;  3ZL8 A;  2VTE A;  1G4W R;  1EEO A;  5A5E A;  1BZJ A;  2JFG A;  2GCA A;  3EU0 A;  1ONZ A;  4J51 A;  1ECV A;  4GE6 A;  4OHL A;  5KAD A;  2J16 B;  1YTS A;  4CVL A;  1WAX A;  1Q6P A;  1JLN A;  4JMJ A;  2I42 A;  1W78 A;  2G59 A;  3BM8 A;  2VEV A;  3RGQ A;  1PTU A;  2QBP A;  4RI5 A;  4RKK A;  2WTZ A;  2H02 A;  2H4V A;  4NWG A;  2BIJ A;  3F9B A;  3ZM5 A;  5IBM A;  2B4P A;  1OEV A;  5BX1 A;  3V0D A;  1OEO X;  3H2X A;  5LXQ B;  3AWF A;  4ICZ A;  3D44 A;  1C84 A;  1YFO A;  3ZV2 A;  5MMZ B;  5GTJ A;  1KAV A;  2I4H A;  5EHR A;  5K23 A;  2Y2F A;  4WU3 A;  4WOH A;  2X5O A;  2F6W A;  2GCB A;  2DXP A;  4AZ1 A;  3NRS A;  3O4T A;  3CM3 A;  4OHI A;  1L8G A;  1NZ7 A;  2F6Y A;  1BZC A;  2QDM A;  2QBS A;  2A3K A;  1W7K A;  3LJ8 A;  3HN7 A;  2Q47 A;  3S3H A;  3EMU A;  1X24 A;  2QDP A;  4C12 A;  4PYH A;  5BUG A;  2BV5 A;  3V0E A;  1U25 A;  4ZI4 A;  2Y66 A;  4R30 A;  4RDD A;  1T48 A;  2QCT A;  2HVL A;  3UAG A;  1XXP A;  4QBE A;  1KAK A;  3A5K A;  2MBC A;  3AWE A;  2F71 A;  3QCM A;  5I6V A;  2HC1 A;  3EB1 A;  1RXD A;  4QBW A;  2E0T A;  2VEX A;  5A5F A;  3V0I A;  2CNH A;  2VEW A;  1MKP A;  1NWL A;  3NME A;  4I8N A;  2VOS A;  2Y1O A;  5K22 A;  2CNI A;  2I1Y A;  2CNF A;  2B4S A;  2Y96 A;  1C85 A;  1P3D A;  3QCI A;  1AAX A;  1NNY A;  1YTN A;  1PA1 A;  2NT2 A;  4GRY A;  4ZIY A;  1I57 A;  2RF6 A;  4S0G A;  3F99 A;  2I4G A;  1A5Y A;  2P4D A;  2PQ5 A;  5BZZ A;  2CJZ A;  1Q1M A;  2FH7 A;  3ZM1 A;  1WCH A;  3MVN A;  5EHP A;  3D1O A;  2PI7 A;  3ZMQ A;  2ZMM A;  3ZMP A;  3O4U A;  2G6Z A;  4RH5 A;  5KAB A;  1YWF A;  5KAC A;  2BZL A;  1XRI A;  4KI9 A;  2CM7 A;  1G4U S;  4MBB A;  4Y14 A;  2F6Z A;  3M4U A;  3N2A A;  5K9W A;  4ZRT A;  1YTW A;  2CM3 A;  1YPT A;  2H4G A;  2OC3 A;  4HJP A;  3QCF A;  3BRH A;  2I75 A;  5KAA A;  1FGS A;  3QCN A;  2VEU A;  3ZM6 A;  2I3U A;  3A5J A;  4JBC A;  3V0J A;  3MMJ A;  1OHC A;  1T49 A;  2R0B A;  4QAH A;  2BGE A;  1NWE A;  2GC5 A;  2I4E A;  2WJP A;  5HDE A;  1L8K A;  3QCZ A;  1GWZ A;  4D3R A;  1YN9 A;  2AHS A;  1D5R A;  2JJD A;  1PTY A;  2B07 A;  2QCJ A;  3PS5 A;  3OMH A;  2FJN A;  1FPR A;  1OEM X;  1BZH A;  4GE2 A;  1R6H A;  1G1G A;  1O5Z A;  2ESB A;  1YGR A;  1OHE A;  4JMK A;  3F41 A;  2PSZ A;  1G7F A;  1XM2 A;  1ZZW A;  1OET A;  4GS0 A;  3ZM2 A;  2B49 A;  2AM1 A;  1PXH A;  1XXV A;  2CNG A;  5K24 A;  5KA4 A;  2F6T A;  4CVK A;  3F81 A;  1NL9 A;  4QF5 A;  4ERC A;  1OEU A;  1JBW A;  4OHH A;  1Q6S A;  5J8R A;  2Y67 A;  1WRM A;  3MOZ A;  2PT0 A;  1V3A A;  2OOQ A;  2PA5 A;  3EZZ A;  1Q6M A;  2WGP A;  2HY3 A;  2NT7 A;  2BGD A;  2AZR A;  4H1O A;  3LK7 A;  1ZC0 A;  2J17 A;  1PA9 A;  3QCG A;  2CMA A;  4BJO A;  1G7G A;  4JNB A;  1E0D A;  3D42 A;  3GXG A;  3PYZ A;  1PTV A;  1U24 A;  5KA3 A;  2Y68 A;  2QEP A;  1UAG A;  5K9V A;  4H34 A;  2I6M A;  3V0G A;  2HCM A;  2OZ5 A;  3O5X A;  4PVG A;  2F46 A;  4ZN5 A;  1LQF A;  1OES A;  1I9T A;  2HB1 A;  4GE5 A;  4D3Q A;  2F00 A;  2Q05 A;  2I3R A;  3S4E A;  4BUC A;  1ZCL A;  4DGP A;  1C87 A;  1C88 A;  1QZ0 A;  2OUD A;  3D1Q A;  5BZX A;  4NYH A;  1M3G A;  2B4U A;  1YZ4 A;  3QKP A;  4NWF A;  2F6F A;  2P6X A;  1OHD A;  1C86 A;  4R0S A;  2CMB A;  3SME A;  2UUP A;  4YAA A; 
#chains in the Genus database with same CATH homology
 4GWF A;  4RHG A;  3QCC A;  3O4S A;  2CFV A;  4QUN A;  4TVV A;  2VEY A;  2I6O A;  2HC2 A;  1PTT A;  1I9S A;  4KYR A;  5KA0 A;  2ZN7 A;  1U26 A;  2CMC A;  1XBO A;  3QKQ A;  2C7S A;  2CNE A;  4RI4 A;  3D9C A;  1P15 A;  1RPM A;  3OLR A;  3V0F A;  2HXP A;  5KA9 A;  2NZ6 A;  3I36 A;  2IMG A;  1G1F A;  3I80 A;  1PH0 A;  2PBN A;  4GRZ A;  1NO6 A;  4NND A;  4GFV A;  2GJT A;  1LYV A;  2C46 A;  4KYQ A;  4IKC A;  2H04 A;  4HJQ A;  4WTY A;  2HNP A;  2GWO A;  2I6P A;  1GFY A;  2QDC A;  2M3V A;  3QCK A;  5IBS A;  1Q6J A;  3RGO A;  1ONY A;  2A8B A;  3SR9 A;  4DGX A;  5KA8 A;  3S3K A;  4Z6B A;  1ZCK A;  2FJM A;  2H03 A;  3CWE A;  2SHP A;  2NV5 A;  3BLT A;  2F6V A;  4Y2E A;  5AWX A;  1T4J A;  3N0A A;  1C83 A;  3BLU A;  4OHD A;  4NX8 A;  3ZM3 A;  3QCJ A;  3QCL A;  1Q6T A;  1J4X A;  2NTA A;  2H4K A;  2YDU A;  4WU2 A;  1QXK A;  2F70 A;  2B3O A;  3S3F A;  1JF7 A;  2I6J A;  4GFU A;  5KA2 A;  3V0H A;  1EEN A;  4BPC A;  1LAR A;  2B4O A;  3QCB A;  4RH9 A;  5K25 A;  2J16 A;  1G1H A;  1PYN A;  3S4O A;  3B7O A;  3QCE A;  3MOW A;  4OHE A;  5KA1 A;  2I5X A;  5KA7 A;  4YR8 B;  2QBR A;  4R0T A;  3RZ2 A;  1Q6N A;  1SUG A;  2I6I A;  1FQ1 A;  3QCH A;  4D3P A;  3GXH A;  3S3E A;  3QCD A;  3AWG A;  3F9A A;  1VHR A;  3ZM0 A;  2HNQ A;  2CM2 A;  3EAX A;  3D1H A;  4B04 A;  3I7Z A;  2CM8 A;  2QBQ A;  5M43 A;  4QUM A;  3O3L A;  3U96 A;  3RO1 A;  1YGU A;  1FPZ A;  4QAP A;  2GP0 A;  2NLK A;  4HRF A;  1G4W R;  1EEO A;  1BZJ A;  3EU0 A;  1ONZ A;  4J51 A;  1ECV A;  4GE6 A;  4OHL A;  5KAD A;  2J16 B;  1YTS A;  1WAX A;  1Q6P A;  1JLN A;  4JMJ A;  2I42 A;  2G59 A;  3BM8 A;  2VEV A;  3RGQ A;  1PTU A;  2QBP A;  4RI5 A;  4RKK A;  2H02 A;  2H4V A;  4NWG A;  2BIJ A;  3F9B A;  5IBM A;  2B4P A;  1OEV A;  5BX1 A;  3V0D A;  1OEO X;  3H2X A;  5LXQ B;  3AWF A;  4ICZ A;  3D44 A;  1C84 A;  1YFO A;  3ZV2 A;  5MMZ B;  5GTJ A;  1KAV A;  2I4H A;  5EHR A;  5K23 A;  2Y2F A;  4WU3 A;  4WOH A;  2F6W A;  2DXP A;  4AZ1 A;  3O4T A;  3CM3 A;  4OHI A;  1L8G A;  1NZ7 A;  2F6Y A;  1BZC A;  2QDM A;  2QBS A;  2A3K A;  3LJ8 A;  2Q47 A;  3S3H A;  3EMU A;  1X24 A;  2QDP A;  4PYH A;  5BUG A;  2BV5 A;  3V0E A;  1U25 A;  4ZI4 A;  4R30 A;  4RDD A;  1T48 A;  2QCT A;  2HVL A;  1XXP A;  4QBE A;  1KAK A;  3A5K A;  2MBC A;  3AWE A;  2F71 A;  3QCM A;  5I6V A;  2HC1 A;  3EB1 A;  1RXD A;  4QBW A;  2E0T A;  2VEX A;  3V0I A;  2CNH A;  2VEW A;  1MKP A;  1NWL A;  3NME A;  4I8N A;  5K22 A;  2CNI A;  2I1Y A;  2CNF A;  2B4S A;  2Y96 A;  1C85 A;  3QCI A;  1AAX A;  1NNY A;  1YTN A;  1PA1 A;  2NT2 A;  4GRY A;  1I57 A;  2RF6 A;  4S0G A;  3F99 A;  2I4G A;  1A5Y A;  2P4D A;  2PQ5 A;  5BZZ A;  2CJZ A;  1Q1M A;  2FH7 A;  3ZM1 A;  1WCH A;  5EHP A;  3D1O A;  2PI7 A;  3ZMQ A;  2ZMM A;  3ZMP A;  3O4U A;  2G6Z A;  4RH5 A;  5KAB A;  1YWF A;  5KAC A;  2BZL A;  1XRI A;  4KI9 A;  2CM7 A;  1G4U S;  4MBB A;  4Y14 A;  2F6Z A;  3M4U A;  5K9W A;  4ZRT A;  1YTW A;  2CM3 A;  1YPT A;  2H4G A;  2OC3 A;  4HJP A;  3QCF A;  3BRH A;  2I75 A;  5KAA A;  3QCN A;  2VEU A;  2I3U A;  3A5J A;  4JBC A;  3V0J A;  3MMJ A;  1OHC A;  1T49 A;  2R0B A;  4QAH A;  2BGE A;  1NWE A;  2I4E A;  5HDE A;  1L8K A;  1GWZ A;  4D3R A;  1YN9 A;  2AHS A;  1D5R A;  2JJD A;  3PS5 A;  1PTY A;  2B07 A;  2QCJ A;  3OMH A;  2FJN A;  1FPR A;  1OEM X;  1BZH A;  4GE2 A;  1R6H A;  1G1G A;  2ESB A;  1YGR A;  1OHE A;  4JMK A;  3F41 A;  2PSZ A;  1G7F A;  1XM2 A;  1ZZW A;  1OET A;  4GS0 A;  3ZM2 A;  2B49 A;  1PXH A;  1XXV A;  2CNG A;  5K24 A;  5KA4 A;  2F6T A;  3F81 A;  1NL9 A;  4ERC A;  1OEU A;  4OHH A;  1Q6S A;  5J8R A;  1WRM A;  3MOZ A;  2PT0 A;  1V3A A;  2OOQ A;  2PA5 A;  3EZZ A;  1Q6M A;  2WGP A;  2HY3 A;  2NT7 A;  2BGD A;  2AZR A;  4H1O A;  1ZC0 A;  2J17 A;  1PA9 A;  3QCG A;  2CMA A;  4BJO A;  1G7G A;  4JNB A;  3D42 A;  3GXG A;  1PTV A;  1U24 A;  5KA3 A;  2QEP A;  5K9V A;  4H34 A;  2I6M A;  3V0G A;  2HCM A;  2OZ5 A;  3O5X A;  4PVG A;  2F46 A;  4ZN5 A;  1LQF A;  1OES A;  1I9T A;  2HB1 A;  4GE5 A;  4D3Q A;  2Q05 A;  2I3R A;  3S4E A;  1ZCL A;  4DGP A;  1C87 A;  1C88 A;  1QZ0 A;  2OUD A;  3D1Q A;  5BZX A;  4NYH A;  1M3G A;  2B4U A;  1YZ4 A;  3QKP A;  4NWF A;  2F6F A;  2P6X A;  1OHD A;  1C86 A;  4R0S A;  2CMB A;  3SME A;  4YAA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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