2CMBA

Structural basis for inhibition of protein tyrosine phosphatase 1b by isothiazolidinone heterocyclic phosphonate mimetics
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
286
structure length
286
Chain Sequence
MHHHHHHEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
total genus 100
structure length 286
sequence length 286
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-05-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2cmbA00
2B4PA 2E0TA 2QBQA 2I4EA 4OHIA 1OEOX 3A5JA 1L8KA 3AWFA 4NYHA 2DXPA 1G1GA 3V0HA 1XM2A 5KA1A 2CNHA 3EMUA 1U26A 1XBOA 2Q05A 5KA7A 2AZRA 4RDDA 1FQ1A 3QCGA 3F99A 2OOQA 2H4KA 4ZN5A 5KA8A 1KAVA 2BZLA 4MBBA 2HVLA 1U24A 2CMCA 4GFUA 2F6ZA 1QXKA 1C87A 3ZMQA 2QDCA 2CFVA 4H1OA 4GE2A 3EU0A 2BV5A 1PTYA 1WAXA 4KI9A 4WTYA 2HXPA 2QBSA 3RGOA 1LQFA 1SUGA 2F6TA 3BLTA 5K24A 1ECVA 2SHPA 2FJMA 4Y14A 2I3UA 3O4TA 4ZRTA 3LJ8A 1XXPA 1G7GA 1D5RA 1PTUA 2P4DA 4PYHA 4GRYA 1GFYA 2Q47A 3N0AA 1PH0A 4D3RA 4JMJA 1U25A 1NWLA 1YTNA 4RH5A 1PXHA 4RH9A 4TVVA 1QZ0A 1X24A 5KA9A 1P15A 3ZM0A 2QDPA 1WCHA 1ZC0A 2I1YA 1OEVA 2B4OA 3M4UA 3O4SA 2H02A 2CNFA 1L8GA 2B49A 2B4UA 2ZN7A 2FH7A 1YWFA 4DGXA 1G7FA 4RHGA 5IBMA 4D3QA 2I75A 2FJNA 3EAXA 4J51A 1BZCA 4WU2A 4AZ1A 4S0GA 1ZCLA 2PBNA 3S3FA 1XRIA 1YZ4A 4OHEA 2CM8A 2NZ6A 5K25A 3S4EA 2Y2FA 3QCHA 4WU3A 2VEXA 1OHEA 1FPRA 1OEUA 1Q6JA 1C88A 3BLUA 1NL9A 1PA9A 2F71A 3D1HA 5I6VA 5GTJA 4QBEA 2R0BA 3RO1A 5BZXA 1A5YA 4I8NA 2CMBA 5KACA 4Y2EA 2G59A 1C86A 1I9SA 4HJQA 2OC3A 4GFVA 4OHLA 5EHRA 1LYVA 2CM2A 3V0IA 1C83A 1XXVA 1Q6NA 3QCIA 5BUGA 1AAXA 3ZM2A 2I6MA 5KA0A 2BIJA 1OEMX 5M43A 1Q6MA 1JLNA 3F41A 2ZMMA 2CM7A 1Q6TA 1BZJA 2PI7A 1ONYA 1MKPA 3SR9A 3QCCA 3V0GA 5BZZA 4Z6BA 4PVGA 5IBSA 1FPZA 3OMHA 2C46A 5K23A 1VHRA 1M3GA 1RXDA 2AHSA 1T49A 2PQ5A 2QBRA 1YGRA 2ESBA 2B3OA 5BX1A 3V0EA 3QCDA 3ZM1A 2I3RA 2GP0A 2QCTA 3D1QA 5EHPA 2VEWA 3CWEA 3ZMPA 3O4UA 4YR8B 1C85A 3B7OA 2P6XA 2HB1A 4H34A 3D44A 3RZ2A 3U96A 3QCJA 1OHDA 2PA5A 1Q1MA 2HY3A 2C7SA 2F46A 1ZZWA 4KYRA 3NMEA 2IMGA 1T4JA 4YAAA 4HJPA 1BZHA 2HC1A 4DGPA 4RI4A 2VEYA 2OUDA 2CJZA 2F6FA 3O5XA 1RPMA 1NO6A 1OETA 2Y96A 4R0SA 3QKQA 3A5KA 4NWGA 3PS5A 1OHCA 3QCKA 2B07A 3D9CA 2I4HA 3CM3A 4GS0A 4JMKA 3QCNA 3V0JA 4JBCA 1Q6PA 2I6OA 1NWEA 2YDUA 2NV5A 2QEPA 4WOHA 3AWGA 2I6JA 1KAKA 1V3AA 4QUNA 2HNPA 3QCEA 4RI5A 1EENA 4KYQA 1PA1A 1GWZA 2J16A 2G6ZA 2GJTA 5KAAA 1YFOA 4QAPA 4R0TA 4BPCA 2VEUA 1I57A 3QCLA 2RF6A 1EEOA 2H4VA 4RKKA 3F81A 2PSZA 4GE5A 4QAHA 2I5XA 4ICZA 2H4GA 2CNGA 3I80A 1YGUA 2I42A 2VEVA 1I9TA 3D1OA 5KADA 3F9AA 3QCBA 3BM8A 1PTTA 3OLRA 3S3EA 1C84A 2MBCA 1ZCKA 3EB1A 5KABA 2HNQA 4HRFA 3AWEA 1ONZA 2J17A 2A3KA 3GXGA 2H03A 5KA3A 2F6VA 4GRZA 1T48A 2F70A 4ZI4A 5J8RA 4GE6A 3ZM3A 3QCMA 3I7ZA 2M3VA 3MMJA 4QUMA 3D42A 3F9BA 5K22A 5K9VA 1PTVA 2H04A 4ERCA 2PT0A 1YTWA 4IKCA 3SMEA 2NTAA 1JF7A 4QBWA 3RGQA 2GWOA 2CNIA 1G4US 1Q6SA 4OHDA 5AWXA 4NX8A 4GWFA 3I36A 2HC2A 2HCMA 2B4SA 3GXHA 2OZ5A 3QCFA 4D3PA 5K9WA 3S4OA 1WRMA 2I6PA 4B04A 3MOZA 3V0FA 2NLKA 1G1HA 2NT7A 1R6HA 1NZ7A 2NT2A 1J4XA 5KA2A 1G1FA 5KA4A 2I6IA 1NNYA 2A8BA 1YN9A 2CM3A 2CMAA 4OHHA 3V0DA 2BGDA 4JNBA 2QDMA 3H2XA 2BGEA 3BRHA 3EZZA 3MOWA 4BJOA 2CNEA 3O3LA 4NWFA 2WGPA 3QKPA 2I4GA 5MMZB 1PYNA 2J16B 1G4WR 1LARA 3S3KA 2QCJA 1YTSA 2F6YA 3S3HA 1YPTA 4NNDA 1OESA 3ZV2A 5LXQB 4R30A 2QBPA 2F6WA 2JJDA 5HDEA
chains in the Genus database with same CATH superfamily
2B4PA 2E0TA 2QBQA 2I4EA 2WJPA 4OHIA 1OEOX 2UUOA 1GG4A 3A5JA 1L8KA 3AWFA 4NYHA 2DXPA 1G1GA 3V0HA 1XM2A 5KA1A 2CNHA 3EMUA 1U26A 1XBOA 2Q05A 3QCZA 5KA7A 2AZRA 4RDDA 1FQ1A 4QDIA 3QCGA 2AM2A 3F99A 2OOQA 2H4KA 4ZN5A 5KA8A 1KAVA 2BZLA 4MBBA 2HVLA 1U24A 2CMCA 2Y1OA 4GFUA 2F6ZA 1QXKA 1C87A 3ZMQA 5A5FA 2QDCA 2CFVA 4H1OA 4GE2A 3EU0A 2BV5A 1PTYA 1WAXA 4KI9A 4WTYA 2HXPA 2QBSA 2GC5A 3RGOA 1LQFA 1SUGA 2F6TA 4ZIYA 3BLTA 5K24A 1ECVA 2SHPA 2FJMA 4Y14A 2I3UA 3O4TA 4ZRTA 3LJ8A 3N2AA 4C13A 1XXPA 1G7GA 1D5RA 1PTUA 2P4DA 4PYHA 4GRYA 1GQQA 3PYZA 1GFYA 2Q47A 3N0AA 2F00A 1PH0A 2JFFA 4D3RA 4JMJA 1O5ZA 1U25A 1NWLA 1YTNA 4RH5A 1PXHA 4RH9A 4TVVA 1QZ0A 1X24A 5KA9A 1P15A 3ZM0A 2AM1A 2QDPA 1WCHA 1ZC0A 2VORA 2I1YA 1OEVA 2B4OA 3M4UA 3O4SA 2H02A 2CNFA 1L8GA 2B49A 2B4UA 3ZM6A 2ZN7A 2FH7A 1YWFA 4DGXA 1G7FA 4RHGA 5IBMA 4D3QA 2I75A 2FJNA 3EAXA 4J51A 1BZCA 1GQYA 4WU2A 4QF5A 4AZ1A 4S0GA 1ZCLA 2PBNA 3S3FA 1XRIA 1YZ4A 4OHEA 2CM8A 2NZ6A 5K25A 3S4EA 2Y2FA 3QCHA 1P3DA 4WU3A 2VEXA 1OHEA 1FPRA 1OEUA 1Q6JA 1C88A 3BLUA 1W7KA 2GCBA 1NL9A 1PA9A 2Y66A 2F71A 3D1HA 5I6VA 5A5EA 5GTJA 4QBEA 2R0BA 3RO1A 5BZXA 1A5YA 4I8NA 2CMBA 4UAGA 5KACA 4Y2EA 2G59A 1C86A 1I9SA 4HJQA 2JFHA 2OC3A 4GFVA 4OHLA 5EHRA 1LYVA 3ZL8A 2CM2A 3V0IA 1C83A 1XXVA 1Q6NA 3QCIA 5BUGA 1AAXA 3ZM2A 2I6MA 5KA0A 2BIJA 3NRSA 1OEMX 5M43A 1Q6MA 1JLNA 1E8CA 3F41A 2ZMMA 2CM7A 4CVLA 1BZJA 1Q6TA 2PI7A 3HN7A 1ONYA 1MKPA 3SR9A 3QCCA 3V0GA 5BZZA 4Z6BA 4PVGA 5IBSA 1FPZA 3OMHA 2C46A 2VTEA 5K23A 1VHRA 1M3GA 1RXDA 2AHSA 1T49A 2PQ5A 2QBRA 1YGRA 2ESBA 2B3OA 5BX1A 3V0EA 3QCDA 3ZM1A 2I3RA 2GP0A 3LK7A 2Y67A 2QCTA 3D1QA 5EHPA 2VEWA 3CWEA 3ZMPA 3O4UA 4YR8B 1C85A 3B7OA 2P6XA 2HB1A 4H34A 3D44A 3RZ2A 3U96A 3QCJA 1OHDA 2PA5A 1Q1MA 2HY3A 2C7SA 1FGSA 2F46A 1E0DA 1ZZWA 4KYRA 3NMEA 2IMGA 1T4JA 4YAAA 4CVKA 4HJPA 1BZHA 2HC1A 4DGPA 4RI4A 2VEYA 2OUDA 2CJZA 1W78A 1JBVA 2F6FA 3O5XA 1RPMA 1NO6A 1OETA 2Y96A 4R0SA 3QKQA 3A5KA 4NWGA 3PS5A 1OHCA 3QCKA 2B07A 3D9CA 2I4HA 3CM3A 4GS0A 2UUPA 4JMKA 3QCNA 3V0JA 4JBCA 1Q6PA 2I6OA 1NWEA 2YDUA 2NV5A 2QEPA 4WOHA 3AWGA 2I6JA 1KAKA 1V3AA 4QUNA 2HNPA 3QCEA 4RI5A 1EENA 1J6UA 4KYQA 1PA1A 1GWZA 2J16A 2G6ZA 2GJTA 5KAAA 2GCAA 1YFOA 2WTZA 4QAPA 4R0TA 4BPCA 2VEUA 1I57A 3QCLA 2RF6A 1EEOA 2GC6A 2H4VA 4RKKA 3F81A 1EEHA 2PSZA 4GE5A 4QAHA 2VOSA 2I5XA 4ICZA 2H4GA 2CNGA 2I42A 2VEVA 1YGUA 3I80A 1I9TA 3D1OA 5KADA 3F9AA 3QCBA 3BM8A 1PTTA 3OLRA 3S3EA 1C84A 2MBCA 1ZCKA 3EB1A 5KABA 2HNQA 4HRFA 3AWEA 1ONZA 2J17A 2A3KA 3GXGA 2H03A 5KA3A 2F6VA 3ZM5A 4GRZA 4HV4A 1T48A 2F70A 4ZI4A 2Y68A 5J8RA 4GE6A 3ZM3A 3QCMA 3I7ZA 2M3VA 3MMJA 4QUMA 3D42A 3F9BA 5K22A 5K9VA 1PTVA 1P31A 2H04A 4ERCA 2PT0A 2UAGA 1YTWA 2JFGA 4IKCA 3SMEA 2NTAA 1JF7A 4QBWA 3RGQA 2GWOA 2CNIA 1G4US 1Q6SA 4OHDA 5AWXA 4NX8A 4GWFA 3I36A 2HC2A 2HCMA 2XPCA 2B4SA 3GXHA 2OZ5A 3QCFA 4D3PA 5K9WA 3S4OA 1WRMA 2I6PA 4B04A 3MOZA 3V0FA 2NLKA 1G1HA 2VTDA 2NT7A 1R6HA 1NZ7A 2NT2A 1J4XA 5KA2A 1G1FA 5KA4A 1JBWA 2I6IA 1NNYA 2A8BA 1YN9A 2CM3A 2CMAA 1UAGA 4OHHA 2X5OA 3V0DA 2BGDA 4JNBA 3UAGA 2QDMA 3H2XA 4BUCA 2BGEA 3BRHA 3EZZA 3MOWA 4BJOA 2CNEA 3O3LA 4NWFA 2WGPA 4C12A 4BUBA 3QKPA 2I4GA 5MMZB 1PYNA 2J16B 1G4WR 1LARA 3S3KA 2QCJA 1YTSA 2F6YA 3S3HA 1YPTA 4NNDA 4CVMA 1OESA 3ZV2A 5LXQB 4R30A 2QBPA 2F6WA 2JJDA 2XJAA 5HDEA 3MVNA
chains in the Genus database with same CATH topology
2B4PA 2E0TA 2QBQA 2I4EA 4OHIA 1OEOX 3A5JA 1L8KA 3AWFA 4NYHA 2DXPA 1G1GA 3V0HA 1XM2A 5KA1A 2CNHA 3EMUA 1U26A 1XBOA 2Q05A 5KA7A 2AZRA 4RDDA 1FQ1A 3QCGA 3F99A 2OOQA 2H4KA 4ZN5A 5KA8A 1KAVA 2BZLA 4MBBA 2HVLA 1U24A 2CMCA 4GFUA 2F6ZA 1QXKA 1C87A 3ZMQA 2QDCA 2CFVA 4H1OA 4GE2A 3EU0A 2BV5A 1PTYA 1WAXA 4KI9A 4WTYA 2HXPA 2QBSA 3RGOA 1LQFA 1SUGA 2F6TA 3BLTA 5K24A 1ECVA 2SHPA 2FJMA 4Y14A 2I3UA 3O4TA 4ZRTA 3LJ8A 1XXPA 1G7GA 1D5RA 1PTUA 2P4DA 4PYHA 4GRYA 1GFYA 2Q47A 3N0AA 1PH0A 4D3RA 4JMJA 1U25A 1NWLA 1YTNA 4RH5A 1PXHA 4RH9A 4TVVA 1QZ0A 1X24A 5KA9A 1P15A 3ZM0A 2QDPA 1WCHA 1ZC0A 2I1YA 1OEVA 2B4OA 3M4UA 3O4SA 2H02A 2CNFA 1L8GA 2B49A 2B4UA 2ZN7A 2FH7A 1YWFA 4DGXA 1G7FA 4RHGA 5IBMA 4D3QA 2I75A 2FJNA 3EAXA 4J51A 1BZCA 4WU2A 4AZ1A 4S0GA 1ZCLA 2PBNA 3S3FA 1XRIA 1YZ4A 4OHEA 2CM8A 2NZ6A 5K25A 3S4EA 2Y2FA 3QCHA 4WU3A 2VEXA 1OHEA 1FPRA 1OEUA 1Q6JA 1C88A 3BLUA 1NL9A 1PA9A 2F71A 3D1HA 5I6VA 5GTJA 4QBEA 2R0BA 3RO1A 5BZXA 1A5YA 4I8NA 2CMBA 5KACA 4Y2EA 2G59A 1C86A 1I9SA 4HJQA 2OC3A 4GFVA 4OHLA 5EHRA 1LYVA 2CM2A 3V0IA 1C83A 1XXVA 1Q6NA 3QCIA 5BUGA 1AAXA 3ZM2A 2I6MA 5KA0A 2BIJA 1OEMX 5M43A 1Q6MA 1JLNA 3F41A 2ZMMA 2CM7A 1Q6TA 1BZJA 2PI7A 1ONYA 1MKPA 3SR9A 3QCCA 3V0GA 5BZZA 4Z6BA 4PVGA 5IBSA 1FPZA 3OMHA 2C46A 5K23A 1VHRA 1M3GA 1RXDA 2AHSA 1T49A 2PQ5A 2QBRA 1YGRA 2ESBA 2B3OA 5BX1A 3V0EA 3QCDA 3ZM1A 2I3RA 2GP0A 2QCTA 3D1QA 5EHPA 2VEWA 3CWEA 3ZMPA 3O4UA 4YR8B 1C85A 3B7OA 2P6XA 2HB1A 4H34A 3D44A 3RZ2A 3U96A 3QCJA 1OHDA 2PA5A 1Q1MA 2HY3A 2C7SA 2F46A 1ZZWA 4KYRA 3NMEA 2IMGA 1T4JA 4YAAA 4HJPA 1BZHA 2HC1A 4DGPA 4RI4A 2VEYA 2OUDA 2CJZA 2F6FA 3O5XA 1RPMA 1NO6A 1OETA 2Y96A 4R0SA 3QKQA 3A5KA 4NWGA 3PS5A 1OHCA 3QCKA 2B07A 3D9CA 2I4HA 3CM3A 4GS0A 4JMKA 3QCNA 3V0JA 4JBCA 1Q6PA 2I6OA 1NWEA 2YDUA 2NV5A 2QEPA 4WOHA 3AWGA 2I6JA 1KAKA 1V3AA 4QUNA 2HNPA 3QCEA 4RI5A 1EENA 4KYQA 1PA1A 1GWZA 2J16A 2G6ZA 2GJTA 5KAAA 1YFOA 4QAPA 4R0TA 4BPCA 2VEUA 1I57A 3QCLA 2RF6A 1EEOA 2H4VA 4RKKA 3F81A 2PSZA 4GE5A 4QAHA 2I5XA 4ICZA 2H4GA 2CNGA 3I80A 1YGUA 2I42A 2VEVA 1I9TA 3D1OA 5KADA 3F9AA 3QCBA 3BM8A 1PTTA 3OLRA 3S3EA 1C84A 2MBCA 1ZCKA 3EB1A 5KABA 2HNQA 4HRFA 3AWEA 1ONZA 2J17A 2A3KA 3GXGA 2H03A 5KA3A 2F6VA 4GRZA 1T48A 2F70A 4ZI4A 5J8RA 4GE6A 3ZM3A 3QCMA 3I7ZA 2M3VA 3MMJA 4QUMA 3D42A 3F9BA 5K22A 5K9VA 1PTVA 2H04A 4ERCA 2PT0A 1YTWA 4IKCA 3SMEA 2NTAA 1JF7A 4QBWA 3RGQA 2GWOA 2CNIA 1G4US 1Q6SA 4OHDA 5AWXA 4NX8A 4GWFA 3I36A 2HC2A 2HCMA 2B4SA 3GXHA 2OZ5A 3QCFA 4D3PA 5K9WA 3S4OA 1WRMA 2I6PA 4B04A 3MOZA 3V0FA 2NLKA 1G1HA 2NT7A 1R6HA 1NZ7A 2NT2A 1J4XA 5KA2A 1G1FA 5KA4A 2I6IA 1NNYA 2A8BA 1YN9A 2CM3A 2CMAA 4OHHA 3V0DA 2BGDA 4JNBA 2QDMA 3H2XA 2BGEA 3BRHA 3EZZA 3MOWA 4BJOA 2CNEA 3O3LA 4NWFA 2WGPA 3QKPA 2I4GA 5MMZB 1PYNA 2J16B 1G4WR 1LARA 3S3KA 2QCJA 1YTSA 2F6YA 3S3HA 1YPTA 4NNDA 1OESA 3ZV2A 5LXQB 4R30A 2QBPA 2F6WA 2JJDA 5HDEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B4P A;  2E0T A;  2QBQ A;  2I4E A;  4OHI A;  1OEO X;  3A5J A;  1L8K A;  3AWF A;  4NYH A;  2DXP A;  1G1G A;  3V0H A;  1XM2 A;  5KA1 A;  2CNH A;  3EMU A;  1U26 A;  1XBO A;  2Q05 A;  5KA7 A;  2AZR A;  4RDD A;  1FQ1 A;  3QCG A;  3F99 A;  2OOQ A;  2H4K A;  4ZN5 A;  5KA8 A;  1KAV A;  2BZL A;  4MBB A;  2HVL A;  1U24 A;  2CMC A;  4GFU A;  2F6Z A;  1QXK A;  1C87 A;  3ZMQ A;  2QDC A;  2CFV A;  4H1O A;  4GE2 A;  3EU0 A;  2BV5 A;  1PTY A;  1WAX A;  4KI9 A;  4WTY A;  2HXP A;  2QBS A;  3RGO A;  1LQF A;  1SUG A;  2F6T A;  3BLT A;  5K24 A;  1ECV A;  2SHP A;  2FJM A;  4Y14 A;  2I3U A;  3O4T A;  4ZRT A;  3LJ8 A;  1XXP A;  1G7G A;  1D5R A;  1PTU A;  2P4D A;  4PYH A;  4GRY A;  1GFY A;  2Q47 A;  3N0A A;  1PH0 A;  4D3R A;  4JMJ A;  1U25 A;  1NWL A;  1YTN A;  4RH5 A;  1PXH A;  4RH9 A;  4TVV A;  1QZ0 A;  1X24 A;  5KA9 A;  1P15 A;  3ZM0 A;  2QDP A;  1WCH A;  1ZC0 A;  2I1Y A;  1OEV A;  2B4O A;  3M4U A;  3O4S A;  2H02 A;  2CNF A;  1L8G A;  2B49 A;  2B4U A;  2ZN7 A;  2FH7 A;  1YWF A;  4DGX A;  1G7F A;  4RHG A;  5IBM A;  4D3Q A;  2I75 A;  2FJN A;  3EAX A;  4J51 A;  1BZC A;  4WU2 A;  4AZ1 A;  4S0G A;  1ZCL A;  2PBN A;  3S3F A;  1XRI A;  1YZ4 A;  4OHE A;  2CM8 A;  2NZ6 A;  5K25 A;  3S4E A;  2Y2F A;  3QCH A;  4WU3 A;  2VEX A;  1OHE A;  1FPR A;  1OEU A;  1Q6J A;  1C88 A;  3BLU A;  1NL9 A;  1PA9 A;  2F71 A;  3D1H A;  5I6V A;  5GTJ A;  4QBE A;  2R0B A;  3RO1 A;  5BZX A;  1A5Y A;  4I8N A;  2CMB A;  5KAC A;  4Y2E A;  2G59 A;  1C86 A;  1I9S A;  4HJQ A;  2OC3 A;  4GFV A;  4OHL A;  5EHR A;  1LYV A;  2CM2 A;  3V0I A;  1C83 A;  1XXV A;  1Q6N A;  3QCI A;  5BUG A;  1AAX A;  3ZM2 A;  2I6M A;  5KA0 A;  2BIJ A;  1OEM X;  5M43 A;  1Q6M A;  1JLN A;  3F41 A;  2ZMM A;  2CM7 A;  1Q6T A;  1BZJ A;  2PI7 A;  1ONY A;  1MKP A;  3SR9 A;  3QCC A;  3V0G A;  5BZZ A;  4Z6B A;  4PVG A;  5IBS A;  1FPZ A;  3OMH A;  2C46 A;  5K23 A;  1VHR A;  1M3G A;  1RXD A;  2AHS A;  1T49 A;  2PQ5 A;  2QBR A;  1YGR A;  2ESB A;  2B3O A;  5BX1 A;  3V0E A;  3QCD A;  3ZM1 A;  2I3R A;  2GP0 A;  2QCT A;  3D1Q A;  5EHP A;  2VEW A;  3CWE A;  3ZMP A;  3O4U A;  4YR8 B;  1C85 A;  3B7O A;  2P6X A;  2HB1 A;  4H34 A;  3D44 A;  3RZ2 A;  3U96 A;  3QCJ A;  1OHD A;  2PA5 A;  1Q1M A;  2HY3 A;  2C7S A;  2F46 A;  1ZZW A;  4KYR A;  3NME A;  2IMG A;  1T4J A;  4YAA A;  4HJP A;  1BZH A;  2HC1 A;  4DGP A;  4RI4 A;  2VEY A;  2OUD A;  2CJZ A;  2F6F A;  3O5X A;  1RPM A;  1NO6 A;  1OET A;  2Y96 A;  4R0S A;  3QKQ A;  3A5K A;  4NWG A;  3PS5 A;  1OHC A;  3QCK A;  2B07 A;  3D9C A;  2I4H A;  3CM3 A;  4GS0 A;  4JMK A;  3QCN A;  3V0J A;  4JBC A;  1Q6P A;  2I6O A;  1NWE A;  2YDU A;  2NV5 A;  2QEP A;  4WOH A;  3AWG A;  2I6J A;  1KAK A;  1V3A A;  4QUN A;  2HNP A;  3QCE A;  4RI5 A;  1EEN A;  4KYQ A;  1PA1 A;  1GWZ A;  2J16 A;  2G6Z A;  2GJT A;  5KAA A;  1YFO A;  4QAP A;  4R0T A;  4BPC A;  2VEU A;  1I57 A;  3QCL A;  2RF6 A;  1EEO A;  2H4V A;  4RKK A;  3F81 A;  2PSZ A;  4GE5 A;  4QAH A;  2I5X A;  4ICZ A;  2H4G A;  2CNG A;  3I80 A;  1YGU A;  2I42 A;  2VEV A;  1I9T A;  3D1O A;  5KAD A;  3F9A A;  3QCB A;  3BM8 A;  1PTT A;  3OLR A;  3S3E A;  1C84 A;  2MBC A;  1ZCK A;  3EB1 A;  5KAB A;  2HNQ A;  4HRF A;  3AWE A;  1ONZ A;  2J17 A;  2A3K A;  3GXG A;  2H03 A;  5KA3 A;  2F6V A;  4GRZ A;  1T48 A;  2F70 A;  4ZI4 A;  5J8R A;  4GE6 A;  3ZM3 A;  3QCM A;  3I7Z A;  2M3V A;  3MMJ A;  4QUM A;  3D42 A;  3F9B A;  5K22 A;  5K9V A;  1PTV A;  2H04 A;  4ERC A;  2PT0 A;  1YTW A;  4IKC A;  3SME A;  2NTA A;  1JF7 A;  4QBW A;  3RGQ A;  2GWO A;  2CNI A;  1G4U S;  1Q6S A;  4OHD A;  5AWX A;  4NX8 A;  4GWF A;  3I36 A;  2HC2 A;  2HCM A;  2B4S A;  3GXH A;  2OZ5 A;  3QCF A;  4D3P A;  5K9W A;  3S4O A;  1WRM A;  2I6P A;  4B04 A;  3MOZ A;  3V0F A;  2NLK A;  1G1H A;  2NT7 A;  1R6H A;  1NZ7 A;  2NT2 A;  1J4X A;  5KA2 A;  1G1F A;  5KA4 A;  2I6I A;  1NNY A;  2A8B A;  1YN9 A;  2CM3 A;  2CMA A;  4OHH A;  3V0D A;  2BGD A;  4JNB A;  2QDM A;  3H2X A;  2BGE A;  3BRH A;  3EZZ A;  3MOW A;  4BJO A;  2CNE A;  3O3L A;  4NWF A;  2WGP A;  3QKP A;  2I4G A;  5MMZ B;  1PYN A;  2J16 B;  1G4W R;  1LAR A;  3S3K A;  2QCJ A;  1YTS A;  2F6Y A;  3S3H A;  1YPT A;  4NND A;  1OES A;  3ZV2 A;  5LXQ B;  4R30 A;  2QBP A;  2F6W A;  2JJD A;  5HDE A; 
#chains in the Genus database with same CATH topology
 2B4P A;  2E0T A;  2QBQ A;  2I4E A;  2WJP A;  4OHI A;  1OEO X;  2UUO A;  1GG4 A;  3A5J A;  1L8K A;  3AWF A;  4NYH A;  2DXP A;  1G1G A;  3V0H A;  1XM2 A;  5KA1 A;  2CNH A;  3EMU A;  1U26 A;  1XBO A;  2Q05 A;  3QCZ A;  5KA7 A;  2AZR A;  4RDD A;  1FQ1 A;  4QDI A;  3QCG A;  2AM2 A;  3F99 A;  2OOQ A;  2H4K A;  4ZN5 A;  5KA8 A;  1KAV A;  2BZL A;  4MBB A;  2HVL A;  1U24 A;  2CMC A;  2Y1O A;  4GFU A;  2F6Z A;  1QXK A;  1C87 A;  3ZMQ A;  5A5F A;  2QDC A;  2CFV A;  4H1O A;  4GE2 A;  3EU0 A;  2BV5 A;  1PTY A;  1WAX A;  4KI9 A;  4WTY A;  2HXP A;  2QBS A;  2GC5 A;  3RGO A;  1LQF A;  1SUG A;  2F6T A;  4ZIY A;  3BLT A;  5K24 A;  1ECV A;  2SHP A;  2FJM A;  4Y14 A;  2I3U A;  3O4T A;  4ZRT A;  3LJ8 A;  3N2A A;  4C13 A;  1XXP A;  1G7G A;  1D5R A;  1PTU A;  2P4D A;  4PYH A;  4GRY A;  1GQQ A;  3PYZ A;  1GFY A;  2Q47 A;  3N0A A;  2F00 A;  1PH0 A;  2JFF A;  4D3R A;  4JMJ A;  1O5Z A;  1U25 A;  1NWL A;  1YTN A;  4RH5 A;  1PXH A;  4RH9 A;  4TVV A;  1QZ0 A;  1X24 A;  5KA9 A;  1P15 A;  3ZM0 A;  2AM1 A;  2QDP A;  1WCH A;  1ZC0 A;  2VOR A;  2I1Y A;  1OEV A;  2B4O A;  3M4U A;  3O4S A;  2H02 A;  2CNF A;  1L8G A;  2B49 A;  2B4U A;  3ZM6 A;  2ZN7 A;  2FH7 A;  1YWF A;  4DGX A;  1G7F A;  4RHG A;  5IBM A;  4D3Q A;  2I75 A;  2FJN A;  3EAX A;  4J51 A;  1BZC A;  1GQY A;  4WU2 A;  4QF5 A;  4AZ1 A;  4S0G A;  1ZCL A;  2PBN A;  3S3F A;  1XRI A;  1YZ4 A;  4OHE A;  2CM8 A;  2NZ6 A;  5K25 A;  3S4E A;  2Y2F A;  3QCH A;  1P3D A;  4WU3 A;  2VEX A;  1OHE A;  1FPR A;  1OEU A;  1Q6J A;  1C88 A;  3BLU A;  1W7K A;  2GCB A;  1NL9 A;  1PA9 A;  2Y66 A;  2F71 A;  3D1H A;  5I6V A;  5A5E A;  5GTJ A;  4QBE A;  2R0B A;  3RO1 A;  5BZX A;  1A5Y A;  4I8N A;  2CMB A;  4UAG A;  5KAC A;  4Y2E A;  2G59 A;  1C86 A;  1I9S A;  4HJQ A;  2JFH A;  2OC3 A;  4GFV A;  4OHL A;  5EHR A;  1LYV A;  3ZL8 A;  2CM2 A;  3V0I A;  1C83 A;  1XXV A;  1Q6N A;  3QCI A;  5BUG A;  1AAX A;  3ZM2 A;  2I6M A;  5KA0 A;  2BIJ A;  3NRS A;  1OEM X;  5M43 A;  1Q6M A;  1JLN A;  1E8C A;  3F41 A;  2ZMM A;  2CM7 A;  4CVL A;  1BZJ A;  1Q6T A;  2PI7 A;  3HN7 A;  1ONY A;  1MKP A;  3SR9 A;  3QCC A;  3V0G A;  5BZZ A;  4Z6B A;  4PVG A;  5IBS A;  1FPZ A;  3OMH A;  2C46 A;  2VTE A;  5K23 A;  1VHR A;  1M3G A;  1RXD A;  2AHS A;  1T49 A;  2PQ5 A;  2QBR A;  1YGR A;  2ESB A;  2B3O A;  5BX1 A;  3V0E A;  3QCD A;  3ZM1 A;  2I3R A;  2GP0 A;  3LK7 A;  2Y67 A;  2QCT A;  3D1Q A;  5EHP A;  2VEW A;  3CWE A;  3ZMP A;  3O4U A;  4YR8 B;  1C85 A;  3B7O A;  2P6X A;  2HB1 A;  4H34 A;  3D44 A;  3RZ2 A;  3U96 A;  3QCJ A;  1OHD A;  2PA5 A;  1Q1M A;  2HY3 A;  2C7S A;  1FGS A;  2F46 A;  1E0D A;  1ZZW A;  4KYR A;  3NME A;  2IMG A;  1T4J A;  4YAA A;  4CVK A;  4HJP A;  1BZH A;  2HC1 A;  4DGP A;  4RI4 A;  2VEY A;  2OUD A;  2CJZ A;  1W78 A;  1JBV A;  2F6F A;  3O5X A;  1RPM A;  1NO6 A;  1OET A;  2Y96 A;  4R0S A;  3QKQ A;  3A5K A;  4NWG A;  3PS5 A;  1OHC A;  3QCK A;  2B07 A;  3D9C A;  2I4H A;  3CM3 A;  4GS0 A;  2UUP A;  4JMK A;  3QCN A;  3V0J A;  4JBC A;  1Q6P A;  2I6O A;  1NWE A;  2YDU A;  2NV5 A;  2QEP A;  4WOH A;  3AWG A;  2I6J A;  1KAK A;  1V3A A;  4QUN A;  2HNP A;  3QCE A;  4RI5 A;  1EEN A;  1J6U A;  4KYQ A;  1PA1 A;  1GWZ A;  2J16 A;  2G6Z A;  2GJT A;  5KAA A;  2GCA A;  1YFO A;  2WTZ A;  4QAP A;  4R0T A;  4BPC A;  2VEU A;  1I57 A;  3QCL A;  2RF6 A;  1EEO A;  2GC6 A;  2H4V A;  4RKK A;  3F81 A;  1EEH A;  2PSZ A;  4GE5 A;  4QAH A;  2VOS A;  2I5X A;  4ICZ A;  2H4G A;  2CNG A;  2I42 A;  2VEV A;  1YGU A;  3I80 A;  1I9T A;  3D1O A;  5KAD A;  3F9A A;  3QCB A;  3BM8 A;  1PTT A;  3OLR A;  3S3E A;  1C84 A;  2MBC A;  1ZCK A;  3EB1 A;  5KAB A;  2HNQ A;  4HRF A;  3AWE A;  1ONZ A;  2J17 A;  2A3K A;  3GXG A;  2H03 A;  5KA3 A;  2F6V A;  3ZM5 A;  4GRZ A;  4HV4 A;  1T48 A;  2F70 A;  4ZI4 A;  2Y68 A;  5J8R A;  4GE6 A;  3ZM3 A;  3QCM A;  3I7Z A;  2M3V A;  3MMJ A;  4QUM A;  3D42 A;  3F9B A;  5K22 A;  5K9V A;  1PTV A;  1P31 A;  2H04 A;  4ERC A;  2PT0 A;  2UAG A;  1YTW A;  2JFG A;  4IKC A;  3SME A;  2NTA A;  1JF7 A;  4QBW A;  3RGQ A;  2GWO A;  2CNI A;  1G4U S;  1Q6S A;  4OHD A;  5AWX A;  4NX8 A;  4GWF A;  3I36 A;  2HC2 A;  2HCM A;  2XPC A;  2B4S A;  3GXH A;  2OZ5 A;  3QCF A;  4D3P A;  5K9W A;  3S4O A;  1WRM A;  2I6P A;  4B04 A;  3MOZ A;  3V0F A;  2NLK A;  1G1H A;  2VTD A;  2NT7 A;  1R6H A;  1NZ7 A;  2NT2 A;  1J4X A;  5KA2 A;  1G1F A;  5KA4 A;  1JBW A;  2I6I A;  1NNY A;  2A8B A;  1YN9 A;  2CM3 A;  2CMA A;  1UAG A;  4OHH A;  2X5O A;  3V0D A;  2BGD A;  4JNB A;  3UAG A;  2QDM A;  3H2X A;  4BUC A;  2BGE A;  3BRH A;  3EZZ A;  3MOW A;  4BJO A;  2CNE A;  3O3L A;  4NWF A;  2WGP A;  4C12 A;  4BUB A;  3QKP A;  2I4G A;  5MMZ B;  1PYN A;  2J16 B;  1G4W R;  1LAR A;  3S3K A;  2QCJ A;  1YTS A;  2F6Y A;  3S3H A;  1YPT A;  4NND A;  4CVM A;  1OES A;  3ZV2 A;  5LXQ B;  4R30 A;  2QBP A;  2F6W A;  2JJD A;  2XJA A;  5HDE A;  3MVN A; 
#chains in the Genus database with same CATH homology
 2B4P A;  2E0T A;  2QBQ A;  2I4E A;  4OHI A;  1OEO X;  3A5J A;  1L8K A;  3AWF A;  4NYH A;  2DXP A;  1G1G A;  3V0H A;  1XM2 A;  5KA1 A;  2CNH A;  3EMU A;  1U26 A;  1XBO A;  2Q05 A;  5KA7 A;  2AZR A;  4RDD A;  1FQ1 A;  3QCG A;  3F99 A;  2OOQ A;  2H4K A;  4ZN5 A;  5KA8 A;  1KAV A;  2BZL A;  4MBB A;  2HVL A;  1U24 A;  2CMC A;  4GFU A;  2F6Z A;  1QXK A;  1C87 A;  3ZMQ A;  2QDC A;  2CFV A;  4H1O A;  4GE2 A;  3EU0 A;  2BV5 A;  1PTY A;  1WAX A;  4KI9 A;  4WTY A;  2HXP A;  2QBS A;  3RGO A;  1LQF A;  1SUG A;  2F6T A;  3BLT A;  5K24 A;  1ECV A;  2SHP A;  2FJM A;  4Y14 A;  2I3U A;  3O4T A;  4ZRT A;  3LJ8 A;  1XXP A;  1G7G A;  1D5R A;  1PTU A;  2P4D A;  4PYH A;  4GRY A;  1GFY A;  2Q47 A;  3N0A A;  1PH0 A;  4D3R A;  4JMJ A;  1U25 A;  1NWL A;  1YTN A;  4RH5 A;  1PXH A;  4RH9 A;  4TVV A;  1QZ0 A;  1X24 A;  5KA9 A;  1P15 A;  3ZM0 A;  2QDP A;  1WCH A;  1ZC0 A;  2I1Y A;  1OEV A;  2B4O A;  3M4U A;  3O4S A;  2H02 A;  2CNF A;  1L8G A;  2B49 A;  2B4U A;  2ZN7 A;  2FH7 A;  1YWF A;  4DGX A;  1G7F A;  4RHG A;  5IBM A;  4D3Q A;  2I75 A;  2FJN A;  3EAX A;  4J51 A;  1BZC A;  4WU2 A;  4AZ1 A;  4S0G A;  1ZCL A;  2PBN A;  3S3F A;  1XRI A;  1YZ4 A;  4OHE A;  2CM8 A;  2NZ6 A;  5K25 A;  3S4E A;  2Y2F A;  3QCH A;  4WU3 A;  2VEX A;  1OHE A;  1FPR A;  1OEU A;  1Q6J A;  1C88 A;  3BLU A;  1NL9 A;  1PA9 A;  2F71 A;  3D1H A;  5I6V A;  5GTJ A;  4QBE A;  2R0B A;  3RO1 A;  5BZX A;  1A5Y A;  4I8N A;  2CMB A;  5KAC A;  4Y2E A;  2G59 A;  1C86 A;  1I9S A;  4HJQ A;  2OC3 A;  4GFV A;  4OHL A;  5EHR A;  1LYV A;  2CM2 A;  3V0I A;  1C83 A;  1XXV A;  1Q6N A;  3QCI A;  5BUG A;  1AAX A;  3ZM2 A;  2I6M A;  5KA0 A;  2BIJ A;  1OEM X;  5M43 A;  1Q6M A;  1JLN A;  3F41 A;  2ZMM A;  2CM7 A;  1Q6T A;  1BZJ A;  2PI7 A;  1ONY A;  1MKP A;  3SR9 A;  3QCC A;  3V0G A;  5BZZ A;  4Z6B A;  4PVG A;  5IBS A;  1FPZ A;  3OMH A;  2C46 A;  5K23 A;  1VHR A;  1M3G A;  1RXD A;  2AHS A;  1T49 A;  2PQ5 A;  2QBR A;  1YGR A;  2ESB A;  2B3O A;  5BX1 A;  3V0E A;  3QCD A;  3ZM1 A;  2I3R A;  2GP0 A;  2QCT A;  3D1Q A;  5EHP A;  2VEW A;  3CWE A;  3ZMP A;  3O4U A;  4YR8 B;  1C85 A;  3B7O A;  2P6X A;  2HB1 A;  4H34 A;  3D44 A;  3RZ2 A;  3U96 A;  3QCJ A;  1OHD A;  2PA5 A;  1Q1M A;  2HY3 A;  2C7S A;  2F46 A;  1ZZW A;  4KYR A;  3NME A;  2IMG A;  1T4J A;  4YAA A;  4HJP A;  1BZH A;  2HC1 A;  4DGP A;  4RI4 A;  2VEY A;  2OUD A;  2CJZ A;  2F6F A;  3O5X A;  1RPM A;  1NO6 A;  1OET A;  2Y96 A;  4R0S A;  3QKQ A;  3A5K A;  4NWG A;  3PS5 A;  1OHC A;  3QCK A;  2B07 A;  3D9C A;  2I4H A;  3CM3 A;  4GS0 A;  4JMK A;  3QCN A;  3V0J A;  4JBC A;  1Q6P A;  2I6O A;  1NWE A;  2YDU A;  2NV5 A;  2QEP A;  4WOH A;  3AWG A;  2I6J A;  1KAK A;  1V3A A;  4QUN A;  2HNP A;  3QCE A;  4RI5 A;  1EEN A;  4KYQ A;  1PA1 A;  1GWZ A;  2J16 A;  2G6Z A;  2GJT A;  5KAA A;  1YFO A;  4QAP A;  4R0T A;  4BPC A;  2VEU A;  1I57 A;  3QCL A;  2RF6 A;  1EEO A;  2H4V A;  4RKK A;  3F81 A;  2PSZ A;  4GE5 A;  4QAH A;  2I5X A;  4ICZ A;  2H4G A;  2CNG A;  3I80 A;  1YGU A;  2I42 A;  2VEV A;  1I9T A;  3D1O A;  5KAD A;  3F9A A;  3QCB A;  3BM8 A;  1PTT A;  3OLR A;  3S3E A;  1C84 A;  2MBC A;  1ZCK A;  3EB1 A;  5KAB A;  2HNQ A;  4HRF A;  3AWE A;  1ONZ A;  2J17 A;  2A3K A;  3GXG A;  2H03 A;  5KA3 A;  2F6V A;  4GRZ A;  1T48 A;  2F70 A;  4ZI4 A;  5J8R A;  4GE6 A;  3ZM3 A;  3QCM A;  3I7Z A;  2M3V A;  3MMJ A;  4QUM A;  3D42 A;  3F9B A;  5K22 A;  5K9V A;  1PTV A;  2H04 A;  4ERC A;  2PT0 A;  1YTW A;  4IKC A;  3SME A;  2NTA A;  1JF7 A;  4QBW A;  3RGQ A;  2GWO A;  2CNI A;  1G4U S;  1Q6S A;  4OHD A;  5AWX A;  4NX8 A;  4GWF A;  3I36 A;  2HC2 A;  2HCM A;  2B4S A;  3GXH A;  2OZ5 A;  3QCF A;  4D3P A;  5K9W A;  3S4O A;  1WRM A;  2I6P A;  4B04 A;  3MOZ A;  3V0F A;  2NLK A;  1G1H A;  2NT7 A;  1R6H A;  1NZ7 A;  2NT2 A;  1J4X A;  5KA2 A;  1G1F A;  5KA4 A;  2I6I A;  1NNY A;  2A8B A;  1YN9 A;  2CM3 A;  2CMA A;  4OHH A;  3V0D A;  2BGD A;  4JNB A;  2QDM A;  3H2X A;  2BGE A;  3BRH A;  3EZZ A;  3MOW A;  4BJO A;  2CNE A;  3O3L A;  4NWF A;  2WGP A;  3QKP A;  2I4G A;  5MMZ B;  1PYN A;  2J16 B;  1G4W R;  1LAR A;  3S3K A;  2QCJ A;  1YTS A;  2F6Y A;  3S3H A;  1YPT A;  4NND A;  1OES A;  3ZV2 A;  5LXQ B;  4R30 A;  2QBP A;  2F6W A;  2JJD A;  5HDE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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