2CNEA

Structural insights into the design of nonpeptidic isothiazolidinone- containing inhibitors of protein tyrosine phosphatase 1b
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
286
structure length
286
Chain Sequence
MHHHHHHEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
total genus 103
structure length 286
sequence length 286
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2cneA00
1ONYA 2B07A 2I4EA 5HDEA 3QCDA 2CM8A 3RGOA 4R30A 3EB1A 4OHLA 2H4GA 2JJDA 4NWGA 1LQFA 1X24A 5EHRA 4RKKA 5K24A 4R0TA 3O5XA 2J17A 5BZZA 2VEUA 1C86A 2NT2A 4WU3A 1R6HA 4YAAA 1ONZA 2B49A 4KI9A 3EMUA 2G59A 2QBQA 2HNQA 5KABA 1YN9A 1U26A 2J16A 1JLNA 4ZN5A 1XXVA 3D42A 4Y14A 1OESA 4Z6BA 2I42A 2I6PA 2B4PA 5K25A 2Y96A 1OHCA 2HNPA 2HB1A 2Q05A 1FPRA 1PXHA 1WAXA 5EHPA 4NYHA 1SUGA 4GFUA 1YFOA 5AWXA 2CJZA 2E0TA 1I9TA 2NZ6A 3RGQA 5K23A 5K9WA 2R0BA 5K22A 3V0DA 2RF6A 1PTYA 2Q47A 2G6ZA 2I4GA 2P4DA 3QCGA 2MBCA 3BM8A 2ZMMA 4DGPA 4D3QA 4GFVA 1Q6SA 3QCKA 2CM7A 2I75A 5BUGA 1FQ1A 3BRHA 2BGDA 2HY3A 2CNFA 1V3AA 2F6VA 2I1YA 3V0GA 2F46A 1XXPA 1KAVA 5BX1A 2VEWA 4GWFA 5KACA 4GE5A 3D1HA 5KA0A 4B04A 2I3UA 3V0IA 2BZLA 4ERCA 5KA8A 2HC2A 3F9AA 1AAXA 4OHIA 4QAPA 2CMCA 2QDMA 4AZ1A 3NMEA 4RI5A 4D3RA 2PI7A 1OETA 1T49A 3V0JA 1NWEA 3O4TA 4HJPA 3RO1A 1YTSA 5KAAA 1EENA 3QCMA 1ZCLA 2DXPA 4Y2EA 3ZM2A 5LXQB 1Q6JA 2I6OA 3N0AA 4DGXA 1YGUA 1G7GA 3OLRA 2QBPA 1OEOX 4QUMA 5KA9A 2H02A 3ZM0A 3O4UA 2CNIA 4WTYA 4NX8A 5J8RA 1OEVA 2QCTA 2PSZA 3CM3A 2QBSA 3EZZA 4WOHA 3QKQA 1LYVA 1ZCKA 1U25A 2OUDA 4RH5A 4RHGA 1QZ0A 2VEXA 3QCCA 2HCMA 1WCHA 2H04A 4IKCA 2NLKA 1I9SA 2C7SA 3QCNA 1OEMX 3QKPA 5KA1A 2F6WA 2OC3A 1G4WR 2I3RA 3H2XA 3V0FA 1ZZWA 3GXGA 3V0HA 2QCJA 4R0SA 4H1OA 5KADA 2QDCA 2FJNA 2P6XA 2CMBA 1P15A 4RI4A 1G1GA 1NNYA 3QCHA 2F6FA 1GWZA 1PYNA 4WU2A 2A8BA 1T48A 1Q1MA 4ZRTA 2NV5A 3U96A 4QAHA 1Q6PA 3CWEA 3OMHA 2M3VA 2NTAA 3ZM3A 2F6YA 1C84A 2B4UA 2SHPA 3ZMQA 4GE2A 2QBRA 4BPCA 3D9CA 2FJMA 1BZHA 1YTNA 1G4US 4D3PA 3MOWA 3ZV2A 1RPMA 4S0GA 3RZ2A 3F41A 2BIJA 1PTVA 1YTWA 2AZRA 4QUNA 1U24A 1D5RA 1GFYA 1KAKA 4QBWA 2QEPA 1XM2A 2A3KA 2AHSA 1YGRA 4NWFA 1ECVA 2CNHA 1MKPA 2CFVA 2VEYA 3AWFA 3F81A 1C85A 1LARA 1M3GA 5GTJA 3QCLA 5M43A 3EU0A 1NWLA 2VEVA 1QXKA 3I36A 3MMJA 2PQ5A 1I57A 2H03A 2F6ZA 2HVLA 1OEUA 2PA5A 2GWOA 5KA4A 4HRFA 1YZ4A 1JF7A 1ZC0A 5I6VA 1PA9A 4OHEA 3F9BA 1OHDA 1EEOA 2HC1A 4YR8B 3O4SA 5KA3A 2Y2FA 4JMKA 4PYHA 4OHHA 4PVGA 1Q6MA 2BGEA 5K9VA 4RDDA 1G1HA 3S4OA 1L8GA 1PTTA 2FH7A 1XBOA 2J16B 4QBEA 1PH0A 3QCEA 2NT7A 2WGPA 2YDUA 4GE6A 4GRZA 1PTUA 4JMJA 3PS5A 4TVVA 5BZXA 1NL9A 2GP0A 2CNGA 2OOQA 3QCJA 2F71A 3S3KA 4ICZA 1A5YA 1XRIA 3D1OA 2OZ5A 1OHEA 3BLUA 2B3OA 3B7OA 2I6IA 2PBNA 3M4UA 4ZI4A 5IBSA 2CM3A 4MBBA 1C87A 3QCBA 2HXPA 3D1QA 3I80A 3BLTA 2B4SA 2B4OA 3F99A 3GXHA 4I8NA 2QDPA 3MOZA 2GJTA 4JBCA 4KYQA 3QCIA 3I7ZA 4H34A 2ZN7A 3A5JA 3ZM1A 5MMZB 1G7FA 4OHDA 3O3LA 4KYRA 5KA7A 2C46A 2I6JA 4NNDA 1WRMA 5KA2A 2CM2A 3V0EA 2I5XA 4RH9A 3S3EA 2I4HA 1YWFA 4J51A 3S4EA 1RXDA 1BZJA 1Q6NA 1G1FA 1VHRA 1J4XA 4HJQA 2CNEA 1NZ7A 3AWEA 4GRYA 4GS0A 2I6MA 2H4VA 3S3HA 1BZCA 5IBMA 2IMGA 4BJOA 1L8KA 3QCFA 3SMEA 2F6TA 3ZMPA 2PT0A 1T4JA 2F70A 3A5KA 3LJ8A 1PA1A 2BV5A 1NO6A 1Q6TA 2ESBA 3D44A 1FPZA 1C88A 3AWGA 3EAXA 1YPTA 3S3FA 2H4KA 4JNBA 3SR9A 2CMAA 1C83A
chains in the Genus database with same CATH superfamily
1ONYA 2B07A 2I4EA 2VTEA 5HDEA 3QCDA 2CM8A 3RGOA 4R30A 1P3DA 1GQYA 3PYZA 3EB1A 4OHLA 2H4GA 2JJDA 4NWGA 1LQFA 3QCZA 1X24A 5EHRA 4RKKA 5K24A 4R0TA 3O5XA 2J17A 5BZZA 2VEUA 1C86A 5A5EA 2NT2A 4WU3A 1R6HA 4YAAA 1ONZA 2B49A 4KI9A 3EMUA 2G59A 2QBQA 2HNQA 5KABA 1YN9A 2Y67A 1U26A 2J16A 2X5OA 1JLNA 4ZN5A 1XXVA 3D42A 4Y14A 1OESA 4Z6BA 2I42A 2I6PA 2B4PA 5K25A 2Y96A 1OHCA 2HNPA 2HB1A 2Q05A 5A5FA 1FPRA 1PXHA 1WAXA 5EHPA 4NYHA 1SUGA 4GFUA 1YFOA 4BUCA 5AWXA 2CJZA 2E0TA 1I9TA 3UAGA 2NZ6A 3RGQA 5K23A 5K9WA 2R0BA 5K22A 3V0DA 2RF6A 2JFGA 1PTYA 2Q47A 2G6ZA 2I4GA 2P4DA 3QCGA 2MBCA 3BM8A 2WTZA 2ZMMA 4DGPA 4D3QA 4GFVA 1Q6SA 3QCKA 1JBWA 2CM7A 2I75A 5BUGA 2UAGA 1FQ1A 3BRHA 2BGDA 2HY3A 2AM1A 2CNFA 1V3AA 2F6VA 2I1YA 3V0GA 2F46A 1XXPA 4BUBA 1KAVA 5BX1A 2VEWA 4GWFA 5KACA 4GE5A 4QF5A 3D1HA 5KA0A 2XPCA 2GC6A 4B04A 2I3UA 3V0IA 2BZLA 3ZL8A 4ERCA 5KA8A 2HC2A 3F9AA 1AAXA 4OHIA 4QAPA 2CMCA 2QDMA 4AZ1A 4CVLA 3NMEA 4RI5A 4D3RA 2VORA 2PI7A 1OETA 1T49A 3V0JA 1NWEA 3O4TA 4HJPA 3RO1A 1YTSA 5KAAA 1EENA 3QCMA 1ZCLA 2DXPA 4Y2EA 3ZM2A 5LXQB 1Q6JA 2I6OA 3N0AA 4DGXA 1YGUA 1G7GA 3OLRA 2GC5A 2QBPA 1OEOX 4QUMA 5KA9A 2H02A 3ZM0A 3O4UA 2CNIA 4WTYA 4NX8A 5J8RA 1OEVA 2GCAA 2PSZA 2QCTA 2QBSA 3CM3A 3EZZA 4WOHA 3QKQA 1LYVA 1ZCKA 1U25A 2OUDA 4RH5A 4RHGA 1QZ0A 2VEXA 3QCCA 2HCMA 1WCHA 2H04A 4IKCA 2NLKA 1I9SA 2C7SA 4CVKA 3QCNA 1OEMX 3QKPA 5KA1A 2F6WA 2OC3A 1G4WR 2I3RA 3H2XA 3V0FA 1ZZWA 3GXGA 3V0HA 2QCJA 3LK7A 4R0SA 3MVNA 4H1OA 5KADA 2QDCA 2FJNA 2P6XA 2CMBA 1W78A 4C12A 3NRSA 1P15A 4RI4A 1G1GA 1NNYA 3QCHA 2F6FA 1GWZA 1PYNA 2GCBA 2A8BA 4WU2A 1T48A 1Q1MA 4ZRTA 2NV5A 1EEHA 3U96A 4QAHA 2UUPA 1Q6PA 3CWEA 3OMHA 2M3VA 2NTAA 3ZM3A 2F6YA 1C84A 2B4UA 2SHPA 3ZMQA 4GE2A 2QBRA 4BPCA 3D9CA 2FJMA 1BZHA 2F00A 1YTNA 2VOSA 1G4US 4D3PA 3MOWA 3ZV2A 2JFHA 1RPMA 4S0GA 3RZ2A 3F41A 2BIJA 1PTVA 1YTWA 2AZRA 4QUNA 1U24A 2Y68A 1D5RA 1GFYA 1W7KA 1KAKA 4QBWA 2QEPA 1P31A 1XM2A 2A3KA 1FGSA 2AHSA 1YGRA 4NWFA 1ECVA 2VTDA 2XJAA 2CNHA 1MKPA 2CFVA 2VEYA 3AWFA 3F81A 4UAGA 4HV4A 1C85A 1LARA 1M3GA 5GTJA 3QCLA 5M43A 3EU0A 1NWLA 2VEVA 1QXKA 3I36A 1O5ZA 3MMJA 2Y66A 1E0DA 2PQ5A 1I57A 2H03A 2F6ZA 2HVLA 1OEUA 2PA5A 2GWOA 5KA4A 4HRFA 1YZ4A 1JF7A 4QDIA 1ZC0A 5I6VA 1PA9A 4OHEA 3F9BA 2WJPA 1OHDA 4C13A 1EEOA 1JBVA 2HC1A 4YR8B 3O4SA 5KA3A 2Y2FA 1GQQA 4JMKA 4PYHA 4OHHA 4PVGA 1UAGA 1Q6MA 2BGEA 5K9VA 4RDDA 1G1HA 3S4OA 1L8GA 1PTTA 2FH7A 1XBOA 3N2AA 2J16B 4QBEA 1PH0A 3QCEA 2NT7A 2WGPA 2YDUA 4GE6A 4GRZA 1PTUA 3ZM6A 4JMJA 3PS5A 4TVVA 5BZXA 1NL9A 2GP0A 2CNGA 2OOQA 3QCJA 2F71A 3S3KA 4ICZA 1A5YA 1XRIA 3D1OA 2OZ5A 1OHEA 3BLUA 2Y1OA 2B3OA 3B7OA 2I6IA 2PBNA 3M4UA 4ZI4A 3ZM5A 5IBSA 2CM3A 4MBBA 4CVMA 1C87A 3QCBA 2HXPA 3D1QA 3I80A 3HN7A 1GG4A 3BLTA 2B4SA 2B4OA 3F99A 1J6UA 3GXHA 4I8NA 2QDPA 3MOZA 2GJTA 4JBCA 4KYQA 3QCIA 3I7ZA 4H34A 2ZN7A 3A5JA 3ZM1A 5MMZB 1G7FA 4OHDA 3O3LA 1E8CA 4KYRA 5KA7A 2C46A 2I6JA 4NNDA 1WRMA 5KA2A 2JFFA 2CM2A 3V0EA 2I5XA 4RH9A 3S3EA 2I4HA 1YWFA 4J51A 3S4EA 1RXDA 1BZJA 1Q6NA 1G1FA 1VHRA 1J4XA 4HJQA 2CNEA 1NZ7A 3AWEA 4GRYA 4GS0A 2I6MA 2H4VA 3S3HA 1BZCA 5IBMA 2IMGA 4BJOA 2UUOA 1L8KA 3QCFA 3SMEA 4ZIYA 2F6TA 3ZMPA 2PT0A 1T4JA 2F70A 3A5KA 3LJ8A 1PA1A 2AM2A 2BV5A 1NO6A 1Q6TA 2ESBA 3D44A 1FPZA 1C88A 3AWGA 3EAXA 1YPTA 3S3FA 2H4KA 4JNBA 3SR9A 2CMAA 1C83A
chains in the Genus database with same CATH topology
1ONYA 2B07A 2I4EA 5HDEA 3QCDA 2CM8A 3RGOA 4R30A 3EB1A 4OHLA 2H4GA 2JJDA 4NWGA 1LQFA 1X24A 5EHRA 4RKKA 5K24A 4R0TA 3O5XA 2J17A 5BZZA 2VEUA 1C86A 2NT2A 4WU3A 1R6HA 4YAAA 1ONZA 2B49A 4KI9A 3EMUA 2G59A 2QBQA 2HNQA 5KABA 1YN9A 1U26A 2J16A 1JLNA 4ZN5A 1XXVA 3D42A 4Y14A 1OESA 4Z6BA 2I42A 2I6PA 2B4PA 5K25A 2Y96A 1OHCA 2HNPA 2HB1A 2Q05A 1FPRA 1PXHA 1WAXA 5EHPA 4NYHA 1SUGA 4GFUA 1YFOA 5AWXA 2CJZA 2E0TA 1I9TA 2NZ6A 3RGQA 5K23A 5K9WA 2R0BA 5K22A 3V0DA 2RF6A 1PTYA 2Q47A 2G6ZA 2I4GA 2P4DA 3QCGA 2MBCA 3BM8A 2ZMMA 4DGPA 4D3QA 4GFVA 1Q6SA 3QCKA 2CM7A 2I75A 5BUGA 1FQ1A 3BRHA 2BGDA 2HY3A 2CNFA 1V3AA 2F6VA 2I1YA 3V0GA 2F46A 1XXPA 1KAVA 5BX1A 2VEWA 4GWFA 5KACA 4GE5A 3D1HA 5KA0A 4B04A 2I3UA 3V0IA 2BZLA 4ERCA 5KA8A 2HC2A 3F9AA 1AAXA 4OHIA 4QAPA 2CMCA 2QDMA 4AZ1A 3NMEA 4RI5A 4D3RA 2PI7A 1OETA 1T49A 3V0JA 1NWEA 3O4TA 4HJPA 3RO1A 1YTSA 5KAAA 1EENA 3QCMA 1ZCLA 2DXPA 4Y2EA 3ZM2A 5LXQB 1Q6JA 2I6OA 3N0AA 4DGXA 1YGUA 1G7GA 3OLRA 2QBPA 1OEOX 4QUMA 5KA9A 2H02A 3ZM0A 3O4UA 2CNIA 4WTYA 4NX8A 5J8RA 1OEVA 2QCTA 2PSZA 3CM3A 2QBSA 3EZZA 4WOHA 3QKQA 1LYVA 1ZCKA 1U25A 2OUDA 4RH5A 4RHGA 1QZ0A 2VEXA 3QCCA 2HCMA 1WCHA 2H04A 4IKCA 2NLKA 1I9SA 2C7SA 3QCNA 1OEMX 3QKPA 5KA1A 2F6WA 2OC3A 1G4WR 2I3RA 3H2XA 3V0FA 1ZZWA 3GXGA 3V0HA 2QCJA 4R0SA 4H1OA 5KADA 2QDCA 2FJNA 2P6XA 2CMBA 1P15A 4RI4A 1G1GA 1NNYA 3QCHA 2F6FA 1GWZA 1PYNA 4WU2A 2A8BA 1T48A 1Q1MA 4ZRTA 2NV5A 3U96A 4QAHA 1Q6PA 3CWEA 3OMHA 2M3VA 2NTAA 3ZM3A 2F6YA 1C84A 2B4UA 2SHPA 3ZMQA 4GE2A 2QBRA 4BPCA 3D9CA 2FJMA 1BZHA 1YTNA 1G4US 4D3PA 3MOWA 3ZV2A 1RPMA 4S0GA 3RZ2A 3F41A 2BIJA 1PTVA 1YTWA 2AZRA 4QUNA 1U24A 1D5RA 1GFYA 1KAKA 4QBWA 2QEPA 1XM2A 2A3KA 2AHSA 1YGRA 4NWFA 1ECVA 2CNHA 1MKPA 2CFVA 2VEYA 3AWFA 3F81A 1C85A 1LARA 1M3GA 5GTJA 3QCLA 5M43A 3EU0A 1NWLA 2VEVA 1QXKA 3I36A 3MMJA 2PQ5A 1I57A 2H03A 2F6ZA 2HVLA 1OEUA 2PA5A 2GWOA 5KA4A 4HRFA 1YZ4A 1JF7A 1ZC0A 5I6VA 1PA9A 4OHEA 3F9BA 1OHDA 1EEOA 2HC1A 4YR8B 3O4SA 5KA3A 2Y2FA 4JMKA 4PYHA 4OHHA 4PVGA 1Q6MA 2BGEA 5K9VA 4RDDA 1G1HA 3S4OA 1L8GA 1PTTA 2FH7A 1XBOA 2J16B 4QBEA 1PH0A 3QCEA 2NT7A 2WGPA 2YDUA 4GE6A 4GRZA 1PTUA 4JMJA 3PS5A 4TVVA 5BZXA 1NL9A 2GP0A 2CNGA 2OOQA 3QCJA 2F71A 3S3KA 4ICZA 1A5YA 1XRIA 3D1OA 2OZ5A 1OHEA 3BLUA 2B3OA 3B7OA 2I6IA 2PBNA 3M4UA 4ZI4A 5IBSA 2CM3A 4MBBA 1C87A 3QCBA 2HXPA 3D1QA 3I80A 3BLTA 2B4SA 2B4OA 3F99A 3GXHA 4I8NA 2QDPA 3MOZA 2GJTA 4JBCA 4KYQA 3QCIA 3I7ZA 4H34A 2ZN7A 3A5JA 3ZM1A 5MMZB 1G7FA 4OHDA 3O3LA 4KYRA 5KA7A 2C46A 2I6JA 4NNDA 1WRMA 5KA2A 2CM2A 3V0EA 2I5XA 4RH9A 3S3EA 2I4HA 1YWFA 4J51A 3S4EA 1RXDA 1BZJA 1Q6NA 1G1FA 1VHRA 1J4XA 4HJQA 2CNEA 1NZ7A 3AWEA 4GRYA 4GS0A 2I6MA 2H4VA 3S3HA 1BZCA 5IBMA 2IMGA 4BJOA 1L8KA 3QCFA 3SMEA 2F6TA 3ZMPA 2PT0A 1T4JA 2F70A 3A5KA 3LJ8A 1PA1A 2BV5A 1NO6A 1Q6TA 2ESBA 3D44A 1FPZA 1C88A 3AWGA 3EAXA 1YPTA 3S3FA 2H4KA 4JNBA 3SR9A 2CMAA 1C83A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ONY A;  2B07 A;  2I4E A;  5HDE A;  3QCD A;  2CM8 A;  3RGO A;  4R30 A;  3EB1 A;  4OHL A;  2H4G A;  2JJD A;  4NWG A;  1LQF A;  1X24 A;  5EHR A;  4RKK A;  5K24 A;  4R0T A;  3O5X A;  2J17 A;  5BZZ A;  2VEU A;  1C86 A;  2NT2 A;  4WU3 A;  1R6H A;  4YAA A;  1ONZ A;  2B49 A;  4KI9 A;  3EMU A;  2G59 A;  2QBQ A;  2HNQ A;  5KAB A;  1YN9 A;  1U26 A;  2J16 A;  1JLN A;  4ZN5 A;  1XXV A;  3D42 A;  4Y14 A;  1OES A;  4Z6B A;  2I42 A;  2I6P A;  2B4P A;  5K25 A;  2Y96 A;  1OHC A;  2HNP A;  2HB1 A;  2Q05 A;  1FPR A;  1PXH A;  1WAX A;  5EHP A;  4NYH A;  1SUG A;  4GFU A;  1YFO A;  5AWX A;  2CJZ A;  2E0T A;  1I9T A;  2NZ6 A;  3RGQ A;  5K23 A;  5K9W A;  2R0B A;  5K22 A;  3V0D A;  2RF6 A;  1PTY A;  2Q47 A;  2G6Z A;  2I4G A;  2P4D A;  3QCG A;  2MBC A;  3BM8 A;  2ZMM A;  4DGP A;  4D3Q A;  4GFV A;  1Q6S A;  3QCK A;  2CM7 A;  2I75 A;  5BUG A;  1FQ1 A;  3BRH A;  2BGD A;  2HY3 A;  2CNF A;  1V3A A;  2F6V A;  2I1Y A;  3V0G A;  2F46 A;  1XXP A;  1KAV A;  5BX1 A;  2VEW A;  4GWF A;  5KAC A;  4GE5 A;  3D1H A;  5KA0 A;  4B04 A;  2I3U A;  3V0I A;  2BZL A;  4ERC A;  5KA8 A;  2HC2 A;  3F9A A;  1AAX A;  4OHI A;  4QAP A;  2CMC A;  2QDM A;  4AZ1 A;  3NME A;  4RI5 A;  4D3R A;  2PI7 A;  1OET A;  1T49 A;  3V0J A;  1NWE A;  3O4T A;  4HJP A;  3RO1 A;  1YTS A;  5KAA A;  1EEN A;  3QCM A;  1ZCL A;  2DXP A;  4Y2E A;  3ZM2 A;  5LXQ B;  1Q6J A;  2I6O A;  3N0A A;  4DGX A;  1YGU A;  1G7G A;  3OLR A;  2QBP A;  1OEO X;  4QUM A;  5KA9 A;  2H02 A;  3ZM0 A;  3O4U A;  2CNI A;  4WTY A;  4NX8 A;  5J8R A;  1OEV A;  2QCT A;  2PSZ A;  3CM3 A;  2QBS A;  3EZZ A;  4WOH A;  3QKQ A;  1LYV A;  1ZCK A;  1U25 A;  2OUD A;  4RH5 A;  4RHG A;  1QZ0 A;  2VEX A;  3QCC A;  2HCM A;  1WCH A;  2H04 A;  4IKC A;  2NLK A;  1I9S A;  2C7S A;  3QCN A;  1OEM X;  3QKP A;  5KA1 A;  2F6W A;  2OC3 A;  1G4W R;  2I3R A;  3H2X A;  3V0F A;  1ZZW A;  3GXG A;  3V0H A;  2QCJ A;  4R0S A;  4H1O A;  5KAD A;  2QDC A;  2FJN A;  2P6X A;  2CMB A;  1P15 A;  4RI4 A;  1G1G A;  1NNY A;  3QCH A;  2F6F A;  1GWZ A;  1PYN A;  4WU2 A;  2A8B A;  1T48 A;  1Q1M A;  4ZRT A;  2NV5 A;  3U96 A;  4QAH A;  1Q6P A;  3CWE A;  3OMH A;  2M3V A;  2NTA A;  3ZM3 A;  2F6Y A;  1C84 A;  2B4U A;  2SHP A;  3ZMQ A;  4GE2 A;  2QBR A;  4BPC A;  3D9C A;  2FJM A;  1BZH A;  1YTN A;  1G4U S;  4D3P A;  3MOW A;  3ZV2 A;  1RPM A;  4S0G A;  3RZ2 A;  3F41 A;  2BIJ A;  1PTV A;  1YTW A;  2AZR A;  4QUN A;  1U24 A;  1D5R A;  1GFY A;  1KAK A;  4QBW A;  2QEP A;  1XM2 A;  2A3K A;  2AHS A;  1YGR A;  4NWF A;  1ECV A;  2CNH A;  1MKP A;  2CFV A;  2VEY A;  3AWF A;  3F81 A;  1C85 A;  1LAR A;  1M3G A;  5GTJ A;  3QCL A;  5M43 A;  3EU0 A;  1NWL A;  2VEV A;  1QXK A;  3I36 A;  3MMJ A;  2PQ5 A;  1I57 A;  2H03 A;  2F6Z A;  2HVL A;  1OEU A;  2PA5 A;  2GWO A;  5KA4 A;  4HRF A;  1YZ4 A;  1JF7 A;  1ZC0 A;  5I6V A;  1PA9 A;  4OHE A;  3F9B A;  1OHD A;  1EEO A;  2HC1 A;  4YR8 B;  3O4S A;  5KA3 A;  2Y2F A;  4JMK A;  4PYH A;  4OHH A;  4PVG A;  1Q6M A;  2BGE A;  5K9V A;  4RDD A;  1G1H A;  3S4O A;  1L8G A;  1PTT A;  2FH7 A;  1XBO A;  2J16 B;  4QBE A;  1PH0 A;  3QCE A;  2NT7 A;  2WGP A;  2YDU A;  4GE6 A;  4GRZ A;  1PTU A;  4JMJ A;  3PS5 A;  4TVV A;  5BZX A;  1NL9 A;  2GP0 A;  2CNG A;  2OOQ A;  3QCJ A;  2F71 A;  3S3K A;  4ICZ A;  1A5Y A;  1XRI A;  3D1O A;  2OZ5 A;  1OHE A;  3BLU A;  2B3O A;  3B7O A;  2I6I A;  2PBN A;  3M4U A;  4ZI4 A;  5IBS A;  2CM3 A;  4MBB A;  1C87 A;  3QCB A;  2HXP A;  3D1Q A;  3I80 A;  3BLT A;  2B4S A;  2B4O A;  3F99 A;  3GXH A;  4I8N A;  2QDP A;  3MOZ A;  2GJT A;  4JBC A;  4KYQ A;  3QCI A;  3I7Z A;  4H34 A;  2ZN7 A;  3A5J A;  3ZM1 A;  5MMZ B;  1G7F A;  4OHD A;  3O3L A;  4KYR A;  5KA7 A;  2C46 A;  2I6J A;  4NND A;  1WRM A;  5KA2 A;  2CM2 A;  3V0E A;  2I5X A;  4RH9 A;  3S3E A;  2I4H A;  1YWF A;  4J51 A;  3S4E A;  1RXD A;  1BZJ A;  1Q6N A;  1G1F A;  1VHR A;  1J4X A;  4HJQ A;  2CNE A;  1NZ7 A;  3AWE A;  4GRY A;  4GS0 A;  2I6M A;  2H4V A;  3S3H A;  1BZC A;  5IBM A;  2IMG A;  4BJO A;  1L8K A;  3QCF A;  3SME A;  2F6T A;  3ZMP A;  2PT0 A;  1T4J A;  2F70 A;  3A5K A;  3LJ8 A;  1PA1 A;  2BV5 A;  1NO6 A;  1Q6T A;  2ESB A;  3D44 A;  1FPZ A;  1C88 A;  3AWG A;  3EAX A;  1YPT A;  3S3F A;  2H4K A;  4JNB A;  3SR9 A;  2CMA A;  1C83 A; 
#chains in the Genus database with same CATH topology
 1ONY A;  2B07 A;  2I4E A;  2VTE A;  5HDE A;  3QCD A;  2CM8 A;  3RGO A;  4R30 A;  1P3D A;  1GQY A;  3PYZ A;  3EB1 A;  4OHL A;  2H4G A;  2JJD A;  4NWG A;  1LQF A;  3QCZ A;  1X24 A;  5EHR A;  4RKK A;  5K24 A;  4R0T A;  3O5X A;  2J17 A;  5BZZ A;  2VEU A;  1C86 A;  5A5E A;  2NT2 A;  4WU3 A;  1R6H A;  4YAA A;  1ONZ A;  2B49 A;  4KI9 A;  3EMU A;  2G59 A;  2QBQ A;  2HNQ A;  5KAB A;  1YN9 A;  2Y67 A;  1U26 A;  2J16 A;  2X5O A;  1JLN A;  4ZN5 A;  1XXV A;  3D42 A;  4Y14 A;  1OES A;  4Z6B A;  2I42 A;  2I6P A;  2B4P A;  5K25 A;  2Y96 A;  1OHC A;  2HNP A;  2HB1 A;  2Q05 A;  5A5F A;  1FPR A;  1PXH A;  1WAX A;  5EHP A;  4NYH A;  1SUG A;  4GFU A;  1YFO A;  4BUC A;  5AWX A;  2CJZ A;  2E0T A;  1I9T A;  3UAG A;  2NZ6 A;  3RGQ A;  5K23 A;  5K9W A;  2R0B A;  5K22 A;  3V0D A;  2RF6 A;  2JFG A;  1PTY A;  2Q47 A;  2G6Z A;  2I4G A;  2P4D A;  3QCG A;  2MBC A;  3BM8 A;  2WTZ A;  2ZMM A;  4DGP A;  4D3Q A;  4GFV A;  1Q6S A;  3QCK A;  1JBW A;  2CM7 A;  2I75 A;  5BUG A;  2UAG A;  1FQ1 A;  3BRH A;  2BGD A;  2HY3 A;  2AM1 A;  2CNF A;  1V3A A;  2F6V A;  2I1Y A;  3V0G A;  2F46 A;  1XXP A;  4BUB A;  1KAV A;  5BX1 A;  2VEW A;  4GWF A;  5KAC A;  4GE5 A;  4QF5 A;  3D1H A;  5KA0 A;  2XPC A;  2GC6 A;  4B04 A;  2I3U A;  3V0I A;  2BZL A;  3ZL8 A;  4ERC A;  5KA8 A;  2HC2 A;  3F9A A;  1AAX A;  4OHI A;  4QAP A;  2CMC A;  2QDM A;  4AZ1 A;  4CVL A;  3NME A;  4RI5 A;  4D3R A;  2VOR A;  2PI7 A;  1OET A;  1T49 A;  3V0J A;  1NWE A;  3O4T A;  4HJP A;  3RO1 A;  1YTS A;  5KAA A;  1EEN A;  3QCM A;  1ZCL A;  2DXP A;  4Y2E A;  3ZM2 A;  5LXQ B;  1Q6J A;  2I6O A;  3N0A A;  4DGX A;  1YGU A;  1G7G A;  3OLR A;  2GC5 A;  2QBP A;  1OEO X;  4QUM A;  5KA9 A;  2H02 A;  3ZM0 A;  3O4U A;  2CNI A;  4WTY A;  4NX8 A;  5J8R A;  1OEV A;  2GCA A;  2PSZ A;  2QCT A;  2QBS A;  3CM3 A;  3EZZ A;  4WOH A;  3QKQ A;  1LYV A;  1ZCK A;  1U25 A;  2OUD A;  4RH5 A;  4RHG A;  1QZ0 A;  2VEX A;  3QCC A;  2HCM A;  1WCH A;  2H04 A;  4IKC A;  2NLK A;  1I9S A;  2C7S A;  4CVK A;  3QCN A;  1OEM X;  3QKP A;  5KA1 A;  2F6W A;  2OC3 A;  1G4W R;  2I3R A;  3H2X A;  3V0F A;  1ZZW A;  3GXG A;  3V0H A;  2QCJ A;  3LK7 A;  4R0S A;  3MVN A;  4H1O A;  5KAD A;  2QDC A;  2FJN A;  2P6X A;  2CMB A;  1W78 A;  4C12 A;  3NRS A;  1P15 A;  4RI4 A;  1G1G A;  1NNY A;  3QCH A;  2F6F A;  1GWZ A;  1PYN A;  2GCB A;  2A8B A;  4WU2 A;  1T48 A;  1Q1M A;  4ZRT A;  2NV5 A;  1EEH A;  3U96 A;  4QAH A;  2UUP A;  1Q6P A;  3CWE A;  3OMH A;  2M3V A;  2NTA A;  3ZM3 A;  2F6Y A;  1C84 A;  2B4U A;  2SHP A;  3ZMQ A;  4GE2 A;  2QBR A;  4BPC A;  3D9C A;  2FJM A;  1BZH A;  2F00 A;  1YTN A;  2VOS A;  1G4U S;  4D3P A;  3MOW A;  3ZV2 A;  2JFH A;  1RPM A;  4S0G A;  3RZ2 A;  3F41 A;  2BIJ A;  1PTV A;  1YTW A;  2AZR A;  4QUN A;  1U24 A;  2Y68 A;  1D5R A;  1GFY A;  1W7K A;  1KAK A;  4QBW A;  2QEP A;  1P31 A;  1XM2 A;  2A3K A;  1FGS A;  2AHS A;  1YGR A;  4NWF A;  1ECV A;  2VTD A;  2XJA A;  2CNH A;  1MKP A;  2CFV A;  2VEY A;  3AWF A;  3F81 A;  4UAG A;  4HV4 A;  1C85 A;  1LAR A;  1M3G A;  5GTJ A;  3QCL A;  5M43 A;  3EU0 A;  1NWL A;  2VEV A;  1QXK A;  3I36 A;  1O5Z A;  3MMJ A;  2Y66 A;  1E0D A;  2PQ5 A;  1I57 A;  2H03 A;  2F6Z A;  2HVL A;  1OEU A;  2PA5 A;  2GWO A;  5KA4 A;  4HRF A;  1YZ4 A;  1JF7 A;  4QDI A;  1ZC0 A;  5I6V A;  1PA9 A;  4OHE A;  3F9B A;  2WJP A;  1OHD A;  4C13 A;  1EEO A;  1JBV A;  2HC1 A;  4YR8 B;  3O4S A;  5KA3 A;  2Y2F A;  1GQQ A;  4JMK A;  4PYH A;  4OHH A;  4PVG A;  1UAG A;  1Q6M A;  2BGE A;  5K9V A;  4RDD A;  1G1H A;  3S4O A;  1L8G A;  1PTT A;  2FH7 A;  1XBO A;  3N2A A;  2J16 B;  4QBE A;  1PH0 A;  3QCE A;  2NT7 A;  2WGP A;  2YDU A;  4GE6 A;  4GRZ A;  1PTU A;  3ZM6 A;  4JMJ A;  3PS5 A;  4TVV A;  5BZX A;  1NL9 A;  2GP0 A;  2CNG A;  2OOQ A;  3QCJ A;  2F71 A;  3S3K A;  4ICZ A;  1A5Y A;  1XRI A;  3D1O A;  2OZ5 A;  1OHE A;  3BLU A;  2Y1O A;  2B3O A;  3B7O A;  2I6I A;  2PBN A;  3M4U A;  4ZI4 A;  3ZM5 A;  5IBS A;  2CM3 A;  4MBB A;  4CVM A;  1C87 A;  3QCB A;  2HXP A;  3D1Q A;  3I80 A;  3HN7 A;  1GG4 A;  3BLT A;  2B4S A;  2B4O A;  3F99 A;  1J6U A;  3GXH A;  4I8N A;  2QDP A;  3MOZ A;  2GJT A;  4JBC A;  4KYQ A;  3QCI A;  3I7Z A;  4H34 A;  2ZN7 A;  3A5J A;  3ZM1 A;  5MMZ B;  1G7F A;  4OHD A;  3O3L A;  1E8C A;  4KYR A;  5KA7 A;  2C46 A;  2I6J A;  4NND A;  1WRM A;  5KA2 A;  2JFF A;  2CM2 A;  3V0E A;  2I5X A;  4RH9 A;  3S3E A;  2I4H A;  1YWF A;  4J51 A;  3S4E A;  1RXD A;  1BZJ A;  1Q6N A;  1G1F A;  1VHR A;  1J4X A;  4HJQ A;  2CNE A;  1NZ7 A;  3AWE A;  4GRY A;  4GS0 A;  2I6M A;  2H4V A;  3S3H A;  1BZC A;  5IBM A;  2IMG A;  4BJO A;  2UUO A;  1L8K A;  3QCF A;  3SME A;  4ZIY A;  2F6T A;  3ZMP A;  2PT0 A;  1T4J A;  2F70 A;  3A5K A;  3LJ8 A;  1PA1 A;  2AM2 A;  2BV5 A;  1NO6 A;  1Q6T A;  2ESB A;  3D44 A;  1FPZ A;  1C88 A;  3AWG A;  3EAX A;  1YPT A;  3S3F A;  2H4K A;  4JNB A;  3SR9 A;  2CMA A;  1C83 A; 
#chains in the Genus database with same CATH homology
 1ONY A;  2B07 A;  2I4E A;  5HDE A;  3QCD A;  2CM8 A;  3RGO A;  4R30 A;  3EB1 A;  4OHL A;  2H4G A;  2JJD A;  4NWG A;  1LQF A;  1X24 A;  5EHR A;  4RKK A;  5K24 A;  4R0T A;  3O5X A;  2J17 A;  5BZZ A;  2VEU A;  1C86 A;  2NT2 A;  4WU3 A;  1R6H A;  4YAA A;  1ONZ A;  2B49 A;  4KI9 A;  3EMU A;  2G59 A;  2QBQ A;  2HNQ A;  5KAB A;  1YN9 A;  1U26 A;  2J16 A;  1JLN A;  4ZN5 A;  1XXV A;  3D42 A;  4Y14 A;  1OES A;  4Z6B A;  2I42 A;  2I6P A;  2B4P A;  5K25 A;  2Y96 A;  1OHC A;  2HNP A;  2HB1 A;  2Q05 A;  1FPR A;  1PXH A;  1WAX A;  5EHP A;  4NYH A;  1SUG A;  4GFU A;  1YFO A;  5AWX A;  2CJZ A;  2E0T A;  1I9T A;  2NZ6 A;  3RGQ A;  5K23 A;  5K9W A;  2R0B A;  5K22 A;  3V0D A;  2RF6 A;  1PTY A;  2Q47 A;  2G6Z A;  2I4G A;  2P4D A;  3QCG A;  2MBC A;  3BM8 A;  2ZMM A;  4DGP A;  4D3Q A;  4GFV A;  1Q6S A;  3QCK A;  2CM7 A;  2I75 A;  5BUG A;  1FQ1 A;  3BRH A;  2BGD A;  2HY3 A;  2CNF A;  1V3A A;  2F6V A;  2I1Y A;  3V0G A;  2F46 A;  1XXP A;  1KAV A;  5BX1 A;  2VEW A;  4GWF A;  5KAC A;  4GE5 A;  3D1H A;  5KA0 A;  4B04 A;  2I3U A;  3V0I A;  2BZL A;  4ERC A;  5KA8 A;  2HC2 A;  3F9A A;  1AAX A;  4OHI A;  4QAP A;  2CMC A;  2QDM A;  4AZ1 A;  3NME A;  4RI5 A;  4D3R A;  2PI7 A;  1OET A;  1T49 A;  3V0J A;  1NWE A;  3O4T A;  4HJP A;  3RO1 A;  1YTS A;  5KAA A;  1EEN A;  3QCM A;  1ZCL A;  2DXP A;  4Y2E A;  3ZM2 A;  5LXQ B;  1Q6J A;  2I6O A;  3N0A A;  4DGX A;  1YGU A;  1G7G A;  3OLR A;  2QBP A;  1OEO X;  4QUM A;  5KA9 A;  2H02 A;  3ZM0 A;  3O4U A;  2CNI A;  4WTY A;  4NX8 A;  5J8R A;  1OEV A;  2QCT A;  2PSZ A;  3CM3 A;  2QBS A;  3EZZ A;  4WOH A;  3QKQ A;  1LYV A;  1ZCK A;  1U25 A;  2OUD A;  4RH5 A;  4RHG A;  1QZ0 A;  2VEX A;  3QCC A;  2HCM A;  1WCH A;  2H04 A;  4IKC A;  2NLK A;  1I9S A;  2C7S A;  3QCN A;  1OEM X;  3QKP A;  5KA1 A;  2F6W A;  2OC3 A;  1G4W R;  2I3R A;  3H2X A;  3V0F A;  1ZZW A;  3GXG A;  3V0H A;  2QCJ A;  4R0S A;  4H1O A;  5KAD A;  2QDC A;  2FJN A;  2P6X A;  2CMB A;  1P15 A;  4RI4 A;  1G1G A;  1NNY A;  3QCH A;  2F6F A;  1GWZ A;  1PYN A;  4WU2 A;  2A8B A;  1T48 A;  1Q1M A;  4ZRT A;  2NV5 A;  3U96 A;  4QAH A;  1Q6P A;  3CWE A;  3OMH A;  2M3V A;  2NTA A;  3ZM3 A;  2F6Y A;  1C84 A;  2B4U A;  2SHP A;  3ZMQ A;  4GE2 A;  2QBR A;  4BPC A;  3D9C A;  2FJM A;  1BZH A;  1YTN A;  1G4U S;  4D3P A;  3MOW A;  3ZV2 A;  1RPM A;  4S0G A;  3RZ2 A;  3F41 A;  2BIJ A;  1PTV A;  1YTW A;  2AZR A;  4QUN A;  1U24 A;  1D5R A;  1GFY A;  1KAK A;  4QBW A;  2QEP A;  1XM2 A;  2A3K A;  2AHS A;  1YGR A;  4NWF A;  1ECV A;  2CNH A;  1MKP A;  2CFV A;  2VEY A;  3AWF A;  3F81 A;  1C85 A;  1LAR A;  1M3G A;  5GTJ A;  3QCL A;  5M43 A;  3EU0 A;  1NWL A;  2VEV A;  1QXK A;  3I36 A;  3MMJ A;  2PQ5 A;  1I57 A;  2H03 A;  2F6Z A;  2HVL A;  1OEU A;  2PA5 A;  2GWO A;  5KA4 A;  4HRF A;  1YZ4 A;  1JF7 A;  1ZC0 A;  5I6V A;  1PA9 A;  4OHE A;  3F9B A;  1OHD A;  1EEO A;  2HC1 A;  4YR8 B;  3O4S A;  5KA3 A;  2Y2F A;  4JMK A;  4PYH A;  4OHH A;  4PVG A;  1Q6M A;  2BGE A;  5K9V A;  4RDD A;  1G1H A;  3S4O A;  1L8G A;  1PTT A;  2FH7 A;  1XBO A;  2J16 B;  4QBE A;  1PH0 A;  3QCE A;  2NT7 A;  2WGP A;  2YDU A;  4GE6 A;  4GRZ A;  1PTU A;  4JMJ A;  3PS5 A;  4TVV A;  5BZX A;  1NL9 A;  2GP0 A;  2CNG A;  2OOQ A;  3QCJ A;  2F71 A;  3S3K A;  4ICZ A;  1A5Y A;  1XRI A;  3D1O A;  2OZ5 A;  1OHE A;  3BLU A;  2B3O A;  3B7O A;  2I6I A;  2PBN A;  3M4U A;  4ZI4 A;  5IBS A;  2CM3 A;  4MBB A;  1C87 A;  3QCB A;  2HXP A;  3D1Q A;  3I80 A;  3BLT A;  2B4S A;  2B4O A;  3F99 A;  3GXH A;  4I8N A;  2QDP A;  3MOZ A;  2GJT A;  4JBC A;  4KYQ A;  3QCI A;  3I7Z A;  4H34 A;  2ZN7 A;  3A5J A;  3ZM1 A;  5MMZ B;  1G7F A;  4OHD A;  3O3L A;  4KYR A;  5KA7 A;  2C46 A;  2I6J A;  4NND A;  1WRM A;  5KA2 A;  2CM2 A;  3V0E A;  2I5X A;  4RH9 A;  3S3E A;  2I4H A;  1YWF A;  4J51 A;  3S4E A;  1RXD A;  1BZJ A;  1Q6N A;  1G1F A;  1VHR A;  1J4X A;  4HJQ A;  2CNE A;  1NZ7 A;  3AWE A;  4GRY A;  4GS0 A;  2I6M A;  2H4V A;  3S3H A;  1BZC A;  5IBM A;  2IMG A;  4BJO A;  1L8K A;  3QCF A;  3SME A;  2F6T A;  3ZMP A;  2PT0 A;  1T4J A;  2F70 A;  3A5K A;  3LJ8 A;  1PA1 A;  2BV5 A;  1NO6 A;  1Q6T A;  2ESB A;  3D44 A;  1FPZ A;  1C88 A;  3AWG A;  3EAX A;  1YPT A;  3S3F A;  2H4K A;  4JNB A;  3SR9 A;  2CMA A;  1C83 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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