2I5XA

Engineering the ptpbeta catalytic domain with improved crystallization properties
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
290
structure length
280
Chain Sequence
KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRAR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Receptor-type tyrosine-protein phosphatase beta
total genus 103
structure length 280
sequence length 290
chains with identical sequence B
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2i5xA00
4MBBA 2C7SA 4S0GA 5KA1A 1YTWA 4JNBA 1RXDA 4GE2A 4DGXA 3ZM2A 2CMAA 2CM7A 3RO1A 2QBRA 1XXPA 3M4UA 1YFOA 1C86A 2HXPA 4GFVA 1I9SA 1NWEA 1C84A 1YGUA 2E0TA 4J51A 4OHIA 1C88A 1FPRA 1Q6MA 5BUGA 2HCMA 2I4HA 3QCLA 3QKPA 1U26A 3D1HA 1R6HA 5KAAA 3A5JA 3V0EA 2B4UA 1SUGA 3QCMA 1PYNA 1G1HA 1NO6A 3S3HA 4H1OA 1YGRA 2FJNA 1XM2A 2BV5A 3MMJA 2A3KA 4KYQA 5MMZB 2Q47A 4GWFA 4IKCA 5KA0A 1MKPA 2HC1A 4D3QA 5EHRA 5I6VA 1NZ7A 1PA9A 2VEUA 1ZCKA 1VHRA 2I3UA 2BGEA 3N0AA 1BZJA 4ZN5A 1EEOA 1C85A 3NMEA 2HC2A 3GXHA 2VEWA 5KA3A 4OHEA 4QBWA 1YPTA 1Q6TA 2DXPA 4KI9A 2P6XA 1OEOX 3PS5A 2CMCA 1EENA 3QCFA 3AWEA 2BIJA 1YWFA 1BZCA 3D9CA 4HJPA 1PA1A 4WU2A 4JBCA 3CWEA 1OETA 2HVLA 2OC3A 3S4OA 2NZ6A 5KA2A 1JF7A 1PTYA 2ZMMA 2CNHA 1ZZWA 5KABA 4OHLA 1OHDA 2Q05A 5IBMA 2I5XA 3A5KA 3F99A 1XXVA 4GE5A 2F6ZA 3LJ8A 2M3VA 1T49A 1PTVA 2QBSA 4NWGA 1OEUA 5KA7A 3D1QA 2F46A 2P4DA 2C46A 5LXQB 5BZZA 2CNGA 1Q6SA 2GP0A 4I8NA 2A8BA 3QCNA 1G1FA 4BPCA 2MBCA 3QKQA 4ERCA 1P15A 3ZM1A 2JJDA 2PI7A 3BLTA 3V0GA 1ECVA 1ZC0A 1PXHA 2B49A 5K9WA 4YR8B 3QCCA 2RF6A 3EZZA 1WAXA 5M43A 2GJTA 2I4EA 3GXGA 5J8RA 2QDPA 3O5XA 1C83A 2Y96A 2CJZA 3BLUA 4QUMA 5AWXA 3AWGA 2H4VA 1Q6JA 1KAKA 1XBOA 2I4GA 2H04A 2R0BA 3EB1A 4H34A 1PH0A 3SMEA 2QCTA 1QXKA 1YTSA 5K22A 1YN9A 3V0IA 2OOQA 4YAAA 1OESA 4ZRTA 2G59A 2PT0A 4KYRA 2J17A 2PBNA 1OHCA 2F6YA 2NLKA 2CM2A 3EU0A 2OUDA 4AZ1A 3U96A 4OHDA 2ZN7A 4Y2EA 2HB1A 4RH9A 1OEVA 4QUNA 4R0TA 3ZMQA 1G4WR 1C87A 2AHSA 3EAXA 5K23A 5KACA 2FJMA 3SR9A 1A5YA 3BRHA 4WTYA 3BM8A 2I75A 2B4PA 2I6PA 2NT7A 3B7OA 2GWOA 3V0FA 1T4JA 2QBPA 4NNDA 2B3OA 2H4KA 3MOWA 3QCIA 2CNFA 1G4US 4RI5A 4NYHA 4PVGA 1Q6PA 2QDMA 2Y2FA 1RPMA 5K9VA 5KADA 2I42A 2B4OA 3D44A 1YZ4A 3S3FA 4TVVA 4ICZA 4Z6BA 1LARA 2OZ5A 1G7FA 3V0HA 4OHHA 3I7ZA 3F81A 1LQFA 3S4EA 4GE6A 1WRMA 3ZMPA 3ZV2A 3QCKA 2F70A 1XRIA 2F6VA 2QBQA 4NWFA 2H02A 1ONYA 2CNIA 2F6FA 4R0SA 5IBSA 3OLRA 1L8GA 3O4SA 2CMBA 3CM3A 1YTNA 3QCEA 1BZHA 3F9BA 2VEYA 4HJQA 5EHPA 2NV5A 2NT2A 3RGOA 4QAPA 1GFYA 2CFVA 1Q1MA 1U25A 2BGDA 5HDEA 2QEPA 2I1YA 4B04A 4RH5A 4BJOA 1I57A 2J16B 3QCGA 3F9AA 2B4SA 4Y14A 3F41A 2G6ZA 4QAHA 1JLNA 1D5RA 3O3LA 4NX8A 4RKKA 1FPZA 3EMUA 4GFUA 4GS0A 3S3EA 1WCHA 4D3RA 3QCDA 3I36A 2PSZA 1GWZA 2BZLA 2QCJA 2ESBA 5K24A 1OEMX 4JMKA 1QZ0A 1I9TA 5K25A 4RI4A 1PTTA 5BX1A 2AZRA 3RZ2A 2CM3A 2HNQA 4R30A 2QDCA 2HY3A 4PYHA 1PTUA 3V0DA 4WU3A 1KAVA 3QCHA 2IMGA 2CNEA 2VEXA 2H4GA 3QCJA 1FQ1A 2CM8A 3ZM3A 2FH7A 3RGQA 4ZI4A 3S3KA 5BZXA 3V0JA 1Q6NA 1AAXA 2H03A 2I3RA 4WOHA 4GRYA 2VEVA 5GTJA 3QCBA 5KA9A 3O4TA 4RHGA 5KA4A 1LYVA 1NL9A 1U24A 2J16A 2WGPA 1X24A 2I6IA 5KA8A 2F71A 1M3GA 4JMJA 3OMHA 4QBEA 3MOZA 1ZCLA 1G1GA 2F6TA 2I6OA 1ONZA 3O4UA 4GRZA 2PQ5A 3D42A 2PA5A 3H2XA 2NTAA 2I6MA 4DGPA 1OHEA 3I80A 2F6WA 2SHPA 1V3AA 1T48A 4HRFA 3ZM0A 1L8KA 4D3PA 2HNPA 1J4XA 1NWLA 2I6JA 1NNYA 3D1OA 2B07A 2YDUA 1G7GA 4RDDA 3AWFA
chains in the Genus database with same CATH superfamily
4MBBA 2C7SA 4S0GA 5KA1A 1YTWA 4JNBA 1RXDA 4GE2A 4DGXA 3ZM2A 2CMAA 2CM7A 3RO1A 2QBRA 1XXPA 4BUCA 3M4UA 1YFOA 2Y68A 1C86A 2HXPA 2Y66A 4GFVA 1I9SA 1NWEA 1C84A 1YGUA 2E0TA 4J51A 4OHIA 1C88A 1FPRA 1Q6MA 4CVMA 5BUGA 2VORA 2HCMA 2I4HA 3QCLA 3QKPA 1W78A 1U26A 3D1HA 1R6HA 5KAAA 3A5JA 3V0EA 2B4UA 1SUGA 3QCMA 1PYNA 4QF5A 2WJPA 1G1HA 4HV4A 1NO6A 3S3HA 4H1OA 1YGRA 2FJNA 1XM2A 2BV5A 2XPCA 3MMJA 2A3KA 4KYQA 5MMZB 2Q47A 4GWFA 4IKCA 3MVNA 5KA0A 1MKPA 3ZM5A 2HC1A 4D3QA 5EHRA 5I6VA 1NZ7A 2UUOA 1PA9A 2VEUA 1ZCKA 1VHRA 2I3UA 4BUBA 2BGEA 3N0AA 2JFGA 1BZJA 4ZN5A 1EEOA 1C85A 3NMEA 2HC2A 3GXHA 2VEWA 5KA3A 4OHEA 2UUPA 4QBWA 1YPTA 1Q6TA 2DXPA 4KI9A 4UAGA 2P6XA 1OEOX 3PS5A 2CMCA 1EENA 3QCFA 3AWEA 2BIJA 1YWFA 1BZCA 1GQYA 3D9CA 4HJPA 1PA1A 4WU2A 2XJAA 4JBCA 3CWEA 1OETA 2HVLA 2OC3A 3S4OA 2NZ6A 5KA2A 1JF7A 1PTYA 2ZMMA 2CNHA 1ZZWA 5KABA 4OHLA 1UAGA 1OHDA 3ZL8A 2Q05A 5IBMA 2I5XA 3A5KA 3F99A 1XXVA 4GE5A 2F6ZA 3LJ8A 2M3VA 1T49A 1PTVA 2QBSA 4NWGA 1OEUA 5KA7A 3D1QA 2F46A 1J6UA 2P4DA 2C46A 5LXQB 5BZZA 2CNGA 4CVKA 1Q6SA 2GP0A 4I8NA 2A8BA 3QCNA 1G1FA 4BPCA 2AM2A 2GCAA 2MBCA 2GC6A 3QKQA 4ERCA 1P15A 3HN7A 3ZM1A 2Y67A 2JJDA 2PI7A 3BLTA 3V0GA 1ECVA 4C12A 1ZC0A 1PXHA 2B49A 5A5EA 5K9WA 4YR8B 3QCCA 2RF6A 3EZZA 1WAXA 5M43A 2GJTA 2I4EA 3GXGA 2F00A 5J8RA 3ZM6A 2QDPA 3O5XA 1C83A 2Y96A 2CJZA 3BLUA 4QUMA 5AWXA 2X5OA 3AWGA 2H4VA 1Q6JA 1KAKA 1XBOA 2I4GA 2H04A 2R0BA 3EB1A 4H34A 1FGSA 1PH0A 3SMEA 2QCTA 1QXKA 1YTSA 5K22A 1YN9A 3V0IA 2OOQA 4YAAA 1OESA 4ZRTA 2G59A 2PT0A 4KYRA 2J17A 2PBNA 1OHCA 2F6YA 2NLKA 2AM1A 2CM2A 3EU0A 2OUDA 4AZ1A 3U96A 4OHDA 2ZN7A 4Y2EA 2HB1A 2VOSA 4RH9A 1OEVA 4QUNA 4R0TA 3ZMQA 1G4WR 1C87A 2AHSA 3EAXA 5K23A 5KACA 2FJMA 3SR9A 1A5YA 3BRHA 4WTYA 3BM8A 2I75A 2B4PA 2I6PA 2NT7A 3B7OA 2GWOA 3V0FA 1T4JA 2QBPA 4NNDA 2B3OA 2H4KA 3MOWA 3QCIA 2CNFA 1G4US 4RI5A 4NYHA 4PVGA 1Q6PA 2QDMA 2Y2FA 1RPMA 5K9VA 5KADA 2I42A 3LK7A 2B4OA 3D44A 1YZ4A 3S3FA 4TVVA 4ICZA 4Z6BA 1LARA 2OZ5A 1G7FA 3V0HA 4OHHA 3I7ZA 3F81A 1LQFA 3S4EA 4GE6A 1WRMA 3ZMPA 3QCZA 3ZV2A 3QCKA 2F70A 1XRIA 2F6VA 2QBQA 4NWFA 2H02A 1ONYA 2CNIA 2F6FA 4R0SA 5IBSA 3OLRA 1L8GA 3O4SA 2CMBA 3CM3A 1YTNA 3QCEA 1BZHA 3F9BA 4C13A 2VEYA 4HJQA 5EHPA 2NV5A 2NT2A 3RGOA 4QAPA 1GFYA 2CFVA 1Q1MA 1U25A 2BGDA 5HDEA 2QEPA 2I1YA 3PYZA 4B04A 4RH5A 4BJOA 1I57A 1P31A 2J16B 3QCGA 3F9AA 2B4SA 4Y14A 2VTEA 3F41A 2G6ZA 2JFFA 4QAHA 1JLNA 1D5RA 4QDIA 3O3LA 4NX8A 4RKKA 1FPZA 3EMUA 4GFUA 4GS0A 3S3EA 1WCHA 4D3RA 3QCDA 3I36A 2PSZA 1GWZA 2BZLA 2QCJA 2ESBA 2WTZA 5K24A 1OEMX 4JMKA 1QZ0A 1I9TA 1JBVA 5K25A 4RI4A 1PTTA 1P3DA 5BX1A 2AZRA 3RZ2A 2CM3A 2HNQA 4R30A 2QDCA 2HY3A 4PYHA 1PTUA 2GC5A 3V0DA 4WU3A 1GQQA 3UAGA 1KAVA 3QCHA 1E0DA 2IMGA 2CNEA 2VEXA 2H4GA 3QCJA 1FQ1A 2CM8A 3ZM3A 2FH7A 3RGQA 4ZI4A 3N2AA 3S3KA 5BZXA 3V0JA 1JBWA 1Q6NA 1AAXA 2H03A 2I3RA 4WOHA 4GRYA 2VEVA 2GCBA 1EEHA 3QCBA 5GTJA 5KA9A 3O4TA 4RHGA 5KA4A 1LYVA 1NL9A 1U24A 5A5FA 2J16A 2WGPA 1X24A 1O5ZA 2I6IA 5KA8A 2F71A 1M3GA 2UAGA 4JMJA 4ZIYA 2Y1OA 3OMHA 2JFHA 4QBEA 3MOZA 1W7KA 1G1GA 1ZCLA 2F6TA 2I6OA 1ONZA 3O4UA 1E8CA 3NRSA 4GRZA 2PQ5A 3D42A 2PA5A 3H2XA 2NTAA 2I6MA 4DGPA 1OHEA 3I80A 2F6WA 2SHPA 1V3AA 1T48A 4HRFA 3ZM0A 1L8KA 2VTDA 4CVLA 4D3PA 2HNPA 1J4XA 1NWLA 2I6JA 1NNYA 3D1OA 2B07A 2YDUA 1GG4A 1G7GA 4RDDA 3AWFA
chains in the Genus database with same CATH topology
4MBBA 2C7SA 4S0GA 5KA1A 1YTWA 4JNBA 1RXDA 4GE2A 4DGXA 3ZM2A 2CMAA 2CM7A 3RO1A 2QBRA 1XXPA 3M4UA 1YFOA 1C86A 2HXPA 4GFVA 1I9SA 1NWEA 1C84A 1YGUA 2E0TA 4J51A 4OHIA 1C88A 1FPRA 1Q6MA 5BUGA 2HCMA 2I4HA 3QCLA 3QKPA 1U26A 3D1HA 1R6HA 5KAAA 3A5JA 3V0EA 2B4UA 1SUGA 3QCMA 1PYNA 1G1HA 1NO6A 3S3HA 4H1OA 1YGRA 2FJNA 1XM2A 2BV5A 3MMJA 2A3KA 4KYQA 5MMZB 2Q47A 4GWFA 4IKCA 5KA0A 1MKPA 2HC1A 4D3QA 5EHRA 5I6VA 1NZ7A 1PA9A 2VEUA 1ZCKA 1VHRA 2I3UA 2BGEA 3N0AA 1BZJA 4ZN5A 1EEOA 1C85A 3NMEA 2HC2A 3GXHA 2VEWA 5KA3A 4OHEA 4QBWA 1YPTA 1Q6TA 2DXPA 4KI9A 2P6XA 1OEOX 3PS5A 2CMCA 1EENA 3QCFA 3AWEA 2BIJA 1YWFA 1BZCA 3D9CA 4HJPA 1PA1A 4WU2A 4JBCA 3CWEA 1OETA 2HVLA 2OC3A 3S4OA 2NZ6A 5KA2A 1JF7A 1PTYA 2ZMMA 2CNHA 1ZZWA 5KABA 4OHLA 1OHDA 2Q05A 5IBMA 2I5XA 3A5KA 3F99A 1XXVA 4GE5A 2F6ZA 3LJ8A 2M3VA 1T49A 1PTVA 2QBSA 4NWGA 1OEUA 5KA7A 3D1QA 2F46A 2P4DA 2C46A 5LXQB 5BZZA 2CNGA 1Q6SA 2GP0A 4I8NA 2A8BA 3QCNA 1G1FA 4BPCA 2MBCA 3QKQA 4ERCA 1P15A 3ZM1A 2JJDA 2PI7A 3BLTA 3V0GA 1ECVA 1ZC0A 1PXHA 2B49A 5K9WA 4YR8B 3QCCA 2RF6A 3EZZA 1WAXA 5M43A 2GJTA 2I4EA 3GXGA 5J8RA 2QDPA 3O5XA 1C83A 2Y96A 2CJZA 3BLUA 4QUMA 5AWXA 3AWGA 2H4VA 1Q6JA 1KAKA 1XBOA 2I4GA 2H04A 2R0BA 3EB1A 4H34A 1PH0A 3SMEA 2QCTA 1QXKA 1YTSA 5K22A 1YN9A 3V0IA 2OOQA 4YAAA 1OESA 4ZRTA 2G59A 2PT0A 4KYRA 2J17A 2PBNA 1OHCA 2F6YA 2NLKA 2CM2A 3EU0A 2OUDA 4AZ1A 3U96A 4OHDA 2ZN7A 4Y2EA 2HB1A 4RH9A 1OEVA 4QUNA 4R0TA 3ZMQA 1G4WR 1C87A 2AHSA 3EAXA 5K23A 5KACA 2FJMA 3SR9A 1A5YA 3BRHA 4WTYA 3BM8A 2I75A 2B4PA 2I6PA 2NT7A 3B7OA 2GWOA 3V0FA 1T4JA 2QBPA 4NNDA 2B3OA 2H4KA 3MOWA 3QCIA 2CNFA 1G4US 4RI5A 4NYHA 4PVGA 1Q6PA 2QDMA 2Y2FA 1RPMA 5K9VA 5KADA 2I42A 2B4OA 3D44A 1YZ4A 3S3FA 4TVVA 4ICZA 4Z6BA 1LARA 2OZ5A 1G7FA 3V0HA 4OHHA 3I7ZA 3F81A 1LQFA 3S4EA 4GE6A 1WRMA 3ZMPA 3ZV2A 3QCKA 2F70A 1XRIA 2F6VA 2QBQA 4NWFA 2H02A 1ONYA 2CNIA 2F6FA 4R0SA 5IBSA 3OLRA 1L8GA 3O4SA 2CMBA 3CM3A 1YTNA 3QCEA 1BZHA 3F9BA 2VEYA 4HJQA 5EHPA 2NV5A 2NT2A 3RGOA 4QAPA 1GFYA 2CFVA 1Q1MA 1U25A 2BGDA 5HDEA 2QEPA 2I1YA 4B04A 4RH5A 4BJOA 1I57A 2J16B 3QCGA 3F9AA 2B4SA 4Y14A 3F41A 2G6ZA 4QAHA 1JLNA 1D5RA 3O3LA 4NX8A 4RKKA 1FPZA 3EMUA 4GFUA 4GS0A 3S3EA 1WCHA 4D3RA 3QCDA 3I36A 2PSZA 1GWZA 2BZLA 2QCJA 2ESBA 5K24A 1OEMX 4JMKA 1QZ0A 1I9TA 5K25A 4RI4A 1PTTA 5BX1A 2AZRA 3RZ2A 2CM3A 2HNQA 4R30A 2QDCA 2HY3A 4PYHA 1PTUA 3V0DA 4WU3A 1KAVA 3QCHA 2IMGA 2CNEA 2VEXA 2H4GA 3QCJA 1FQ1A 2CM8A 3ZM3A 2FH7A 3RGQA 4ZI4A 3S3KA 5BZXA 3V0JA 1Q6NA 1AAXA 2H03A 2I3RA 4WOHA 4GRYA 2VEVA 5GTJA 3QCBA 5KA9A 3O4TA 4RHGA 5KA4A 1LYVA 1NL9A 1U24A 2J16A 2WGPA 1X24A 2I6IA 5KA8A 2F71A 1M3GA 4JMJA 3OMHA 4QBEA 3MOZA 1ZCLA 1G1GA 2F6TA 2I6OA 1ONZA 3O4UA 4GRZA 2PQ5A 3D42A 2PA5A 3H2XA 2NTAA 2I6MA 4DGPA 1OHEA 3I80A 2F6WA 2SHPA 1V3AA 1T48A 4HRFA 3ZM0A 1L8KA 4D3PA 2HNPA 1J4XA 1NWLA 2I6JA 1NNYA 3D1OA 2B07A 2YDUA 1G7GA 4RDDA 3AWFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MBB A;  2C7S A;  4S0G A;  5KA1 A;  1YTW A;  4JNB A;  1RXD A;  4GE2 A;  4DGX A;  3ZM2 A;  2CMA A;  2CM7 A;  3RO1 A;  2QBR A;  1XXP A;  3M4U A;  1YFO A;  1C86 A;  2HXP A;  4GFV A;  1I9S A;  1NWE A;  1C84 A;  1YGU A;  2E0T A;  4J51 A;  4OHI A;  1C88 A;  1FPR A;  1Q6M A;  5BUG A;  2HCM A;  2I4H A;  3QCL A;  3QKP A;  1U26 A;  3D1H A;  1R6H A;  5KAA A;  3A5J A;  3V0E A;  2B4U A;  1SUG A;  3QCM A;  1PYN A;  1G1H A;  1NO6 A;  3S3H A;  4H1O A;  1YGR A;  2FJN A;  1XM2 A;  2BV5 A;  3MMJ A;  2A3K A;  4KYQ A;  5MMZ B;  2Q47 A;  4GWF A;  4IKC A;  5KA0 A;  1MKP A;  2HC1 A;  4D3Q A;  5EHR A;  5I6V A;  1NZ7 A;  1PA9 A;  2VEU A;  1ZCK A;  1VHR A;  2I3U A;  2BGE A;  3N0A A;  1BZJ A;  4ZN5 A;  1EEO A;  1C85 A;  3NME A;  2HC2 A;  3GXH A;  2VEW A;  5KA3 A;  4OHE A;  4QBW A;  1YPT A;  1Q6T A;  2DXP A;  4KI9 A;  2P6X A;  1OEO X;  3PS5 A;  2CMC A;  1EEN A;  3QCF A;  3AWE A;  2BIJ A;  1YWF A;  1BZC A;  3D9C A;  4HJP A;  1PA1 A;  4WU2 A;  4JBC A;  3CWE A;  1OET A;  2HVL A;  2OC3 A;  3S4O A;  2NZ6 A;  5KA2 A;  1JF7 A;  1PTY A;  2ZMM A;  2CNH A;  1ZZW A;  5KAB A;  4OHL A;  1OHD A;  2Q05 A;  5IBM A;  2I5X A;  3A5K A;  3F99 A;  1XXV A;  4GE5 A;  2F6Z A;  3LJ8 A;  2M3V A;  1T49 A;  1PTV A;  2QBS A;  4NWG A;  1OEU A;  5KA7 A;  3D1Q A;  2F46 A;  2P4D A;  2C46 A;  5LXQ B;  5BZZ A;  2CNG A;  1Q6S A;  2GP0 A;  4I8N A;  2A8B A;  3QCN A;  1G1F A;  4BPC A;  2MBC A;  3QKQ A;  4ERC A;  1P15 A;  3ZM1 A;  2JJD A;  2PI7 A;  3BLT A;  3V0G A;  1ECV A;  1ZC0 A;  1PXH A;  2B49 A;  5K9W A;  4YR8 B;  3QCC A;  2RF6 A;  3EZZ A;  1WAX A;  5M43 A;  2GJT A;  2I4E A;  3GXG A;  5J8R A;  2QDP A;  3O5X A;  1C83 A;  2Y96 A;  2CJZ A;  3BLU A;  4QUM A;  5AWX A;  3AWG A;  2H4V A;  1Q6J A;  1KAK A;  1XBO A;  2I4G A;  2H04 A;  2R0B A;  3EB1 A;  4H34 A;  1PH0 A;  3SME A;  2QCT A;  1QXK A;  1YTS A;  5K22 A;  1YN9 A;  3V0I A;  2OOQ A;  4YAA A;  1OES A;  4ZRT A;  2G59 A;  2PT0 A;  4KYR A;  2J17 A;  2PBN A;  1OHC A;  2F6Y A;  2NLK A;  2CM2 A;  3EU0 A;  2OUD A;  4AZ1 A;  3U96 A;  4OHD A;  2ZN7 A;  4Y2E A;  2HB1 A;  4RH9 A;  1OEV A;  4QUN A;  4R0T A;  3ZMQ A;  1G4W R;  1C87 A;  2AHS A;  3EAX A;  5K23 A;  5KAC A;  2FJM A;  3SR9 A;  1A5Y A;  3BRH A;  4WTY A;  3BM8 A;  2I75 A;  2B4P A;  2I6P A;  2NT7 A;  3B7O A;  2GWO A;  3V0F A;  1T4J A;  2QBP A;  4NND A;  2B3O A;  2H4K A;  3MOW A;  3QCI A;  2CNF A;  1G4U S;  4RI5 A;  4NYH A;  4PVG A;  1Q6P A;  2QDM A;  2Y2F A;  1RPM A;  5K9V A;  5KAD A;  2I42 A;  2B4O A;  3D44 A;  1YZ4 A;  3S3F A;  4TVV A;  4ICZ A;  4Z6B A;  1LAR A;  2OZ5 A;  1G7F A;  3V0H A;  4OHH A;  3I7Z A;  3F81 A;  1LQF A;  3S4E A;  4GE6 A;  1WRM A;  3ZMP A;  3ZV2 A;  3QCK A;  2F70 A;  1XRI A;  2F6V A;  2QBQ A;  4NWF A;  2H02 A;  1ONY A;  2CNI A;  2F6F A;  4R0S A;  5IBS A;  3OLR A;  1L8G A;  3O4S A;  2CMB A;  3CM3 A;  1YTN A;  3QCE A;  1BZH A;  3F9B A;  2VEY A;  4HJQ A;  5EHP A;  2NV5 A;  2NT2 A;  3RGO A;  4QAP A;  1GFY A;  2CFV A;  1Q1M A;  1U25 A;  2BGD A;  5HDE A;  2QEP A;  2I1Y A;  4B04 A;  4RH5 A;  4BJO A;  1I57 A;  2J16 B;  3QCG A;  3F9A A;  2B4S A;  4Y14 A;  3F41 A;  2G6Z A;  4QAH A;  1JLN A;  1D5R A;  3O3L A;  4NX8 A;  4RKK A;  1FPZ A;  3EMU A;  4GFU A;  4GS0 A;  3S3E A;  1WCH A;  4D3R A;  3QCD A;  3I36 A;  2PSZ A;  1GWZ A;  2BZL A;  2QCJ A;  2ESB A;  5K24 A;  1OEM X;  4JMK A;  1QZ0 A;  1I9T A;  5K25 A;  4RI4 A;  1PTT A;  5BX1 A;  2AZR A;  3RZ2 A;  2CM3 A;  2HNQ A;  4R30 A;  2QDC A;  2HY3 A;  4PYH A;  1PTU A;  3V0D A;  4WU3 A;  1KAV A;  3QCH A;  2IMG A;  2CNE A;  2VEX A;  2H4G A;  3QCJ A;  1FQ1 A;  2CM8 A;  3ZM3 A;  2FH7 A;  3RGQ A;  4ZI4 A;  3S3K A;  5BZX A;  3V0J A;  1Q6N A;  1AAX A;  2H03 A;  2I3R A;  4WOH A;  4GRY A;  2VEV A;  5GTJ A;  3QCB A;  5KA9 A;  3O4T A;  4RHG A;  5KA4 A;  1LYV A;  1NL9 A;  1U24 A;  2J16 A;  2WGP A;  1X24 A;  2I6I A;  5KA8 A;  2F71 A;  1M3G A;  4JMJ A;  3OMH A;  4QBE A;  3MOZ A;  1ZCL A;  1G1G A;  2F6T A;  2I6O A;  1ONZ A;  3O4U A;  4GRZ A;  2PQ5 A;  3D42 A;  2PA5 A;  3H2X A;  2NTA A;  2I6M A;  4DGP A;  1OHE A;  3I80 A;  2F6W A;  2SHP A;  1V3A A;  1T48 A;  4HRF A;  3ZM0 A;  1L8K A;  4D3P A;  2HNP A;  1J4X A;  1NWL A;  2I6J A;  1NNY A;  3D1O A;  2B07 A;  2YDU A;  1G7G A;  4RDD A;  3AWF A; 
#chains in the Genus database with same CATH topology
 4MBB A;  2C7S A;  4S0G A;  5KA1 A;  1YTW A;  4JNB A;  1RXD A;  4GE2 A;  4DGX A;  3ZM2 A;  2CMA A;  2CM7 A;  3RO1 A;  2QBR A;  1XXP A;  4BUC A;  3M4U A;  1YFO A;  2Y68 A;  1C86 A;  2HXP A;  2Y66 A;  4GFV A;  1I9S A;  1NWE A;  1C84 A;  1YGU A;  2E0T A;  4J51 A;  4OHI A;  1C88 A;  1FPR A;  1Q6M A;  4CVM A;  5BUG A;  2VOR A;  2HCM A;  2I4H A;  3QCL A;  3QKP A;  1W78 A;  1U26 A;  3D1H A;  1R6H A;  5KAA A;  3A5J A;  3V0E A;  2B4U A;  1SUG A;  3QCM A;  1PYN A;  4QF5 A;  2WJP A;  1G1H A;  4HV4 A;  1NO6 A;  3S3H A;  4H1O A;  1YGR A;  2FJN A;  1XM2 A;  2BV5 A;  2XPC A;  3MMJ A;  2A3K A;  4KYQ A;  5MMZ B;  2Q47 A;  4GWF A;  4IKC A;  3MVN A;  5KA0 A;  1MKP A;  3ZM5 A;  2HC1 A;  4D3Q A;  5EHR A;  5I6V A;  1NZ7 A;  2UUO A;  1PA9 A;  2VEU A;  1ZCK A;  1VHR A;  2I3U A;  4BUB A;  2BGE A;  3N0A A;  2JFG A;  1BZJ A;  4ZN5 A;  1EEO A;  1C85 A;  3NME A;  2HC2 A;  3GXH A;  2VEW A;  5KA3 A;  4OHE A;  2UUP A;  4QBW A;  1YPT A;  1Q6T A;  2DXP A;  4KI9 A;  4UAG A;  2P6X A;  1OEO X;  3PS5 A;  2CMC A;  1EEN A;  3QCF A;  3AWE A;  2BIJ A;  1YWF A;  1BZC A;  1GQY A;  3D9C A;  4HJP A;  1PA1 A;  4WU2 A;  2XJA A;  4JBC A;  3CWE A;  1OET A;  2HVL A;  2OC3 A;  3S4O A;  2NZ6 A;  5KA2 A;  1JF7 A;  1PTY A;  2ZMM A;  2CNH A;  1ZZW A;  5KAB A;  4OHL A;  1UAG A;  1OHD A;  3ZL8 A;  2Q05 A;  5IBM A;  2I5X A;  3A5K A;  3F99 A;  1XXV A;  4GE5 A;  2F6Z A;  3LJ8 A;  2M3V A;  1T49 A;  1PTV A;  2QBS A;  4NWG A;  1OEU A;  5KA7 A;  3D1Q A;  2F46 A;  1J6U A;  2P4D A;  2C46 A;  5LXQ B;  5BZZ A;  2CNG A;  4CVK A;  1Q6S A;  2GP0 A;  4I8N A;  2A8B A;  3QCN A;  1G1F A;  4BPC A;  2AM2 A;  2GCA A;  2MBC A;  2GC6 A;  3QKQ A;  4ERC A;  1P15 A;  3HN7 A;  3ZM1 A;  2Y67 A;  2JJD A;  2PI7 A;  3BLT A;  3V0G A;  1ECV A;  4C12 A;  1ZC0 A;  1PXH A;  2B49 A;  5A5E A;  5K9W A;  4YR8 B;  3QCC A;  2RF6 A;  3EZZ A;  1WAX A;  5M43 A;  2GJT A;  2I4E A;  3GXG A;  2F00 A;  5J8R A;  3ZM6 A;  2QDP A;  3O5X A;  1C83 A;  2Y96 A;  2CJZ A;  3BLU A;  4QUM A;  5AWX A;  2X5O A;  3AWG A;  2H4V A;  1Q6J A;  1KAK A;  1XBO A;  2I4G A;  2H04 A;  2R0B A;  3EB1 A;  4H34 A;  1FGS A;  1PH0 A;  3SME A;  2QCT A;  1QXK A;  1YTS A;  5K22 A;  1YN9 A;  3V0I A;  2OOQ A;  4YAA A;  1OES A;  4ZRT A;  2G59 A;  2PT0 A;  4KYR A;  2J17 A;  2PBN A;  1OHC A;  2F6Y A;  2NLK A;  2AM1 A;  2CM2 A;  3EU0 A;  2OUD A;  4AZ1 A;  3U96 A;  4OHD A;  2ZN7 A;  4Y2E A;  2HB1 A;  2VOS A;  4RH9 A;  1OEV A;  4QUN A;  4R0T A;  3ZMQ A;  1G4W R;  1C87 A;  2AHS A;  3EAX A;  5K23 A;  5KAC A;  2FJM A;  3SR9 A;  1A5Y A;  3BRH A;  4WTY A;  3BM8 A;  2I75 A;  2B4P A;  2I6P A;  2NT7 A;  3B7O A;  2GWO A;  3V0F A;  1T4J A;  2QBP A;  4NND A;  2B3O A;  2H4K A;  3MOW A;  3QCI A;  2CNF A;  1G4U S;  4RI5 A;  4NYH A;  4PVG A;  1Q6P A;  2QDM A;  2Y2F A;  1RPM A;  5K9V A;  5KAD A;  2I42 A;  3LK7 A;  2B4O A;  3D44 A;  1YZ4 A;  3S3F A;  4TVV A;  4ICZ A;  4Z6B A;  1LAR A;  2OZ5 A;  1G7F A;  3V0H A;  4OHH A;  3I7Z A;  3F81 A;  1LQF A;  3S4E A;  4GE6 A;  1WRM A;  3ZMP A;  3QCZ A;  3ZV2 A;  3QCK A;  2F70 A;  1XRI A;  2F6V A;  2QBQ A;  4NWF A;  2H02 A;  1ONY A;  2CNI A;  2F6F A;  4R0S A;  5IBS A;  3OLR A;  1L8G A;  3O4S A;  2CMB A;  3CM3 A;  1YTN A;  3QCE A;  1BZH A;  3F9B A;  4C13 A;  2VEY A;  4HJQ A;  5EHP A;  2NV5 A;  2NT2 A;  3RGO A;  4QAP A;  1GFY A;  2CFV A;  1Q1M A;  1U25 A;  2BGD A;  5HDE A;  2QEP A;  2I1Y A;  3PYZ A;  4B04 A;  4RH5 A;  4BJO A;  1I57 A;  1P31 A;  2J16 B;  3QCG A;  3F9A A;  2B4S A;  4Y14 A;  2VTE A;  3F41 A;  2G6Z A;  2JFF A;  4QAH A;  1JLN A;  1D5R A;  4QDI A;  3O3L A;  4NX8 A;  4RKK A;  1FPZ A;  3EMU A;  4GFU A;  4GS0 A;  3S3E A;  1WCH A;  4D3R A;  3QCD A;  3I36 A;  2PSZ A;  1GWZ A;  2BZL A;  2QCJ A;  2ESB A;  2WTZ A;  5K24 A;  1OEM X;  4JMK A;  1QZ0 A;  1I9T A;  1JBV A;  5K25 A;  4RI4 A;  1PTT A;  1P3D A;  5BX1 A;  2AZR A;  3RZ2 A;  2CM3 A;  2HNQ A;  4R30 A;  2QDC A;  2HY3 A;  4PYH A;  1PTU A;  2GC5 A;  3V0D A;  4WU3 A;  1GQQ A;  3UAG A;  1KAV A;  3QCH A;  1E0D A;  2IMG A;  2CNE A;  2VEX A;  2H4G A;  3QCJ A;  1FQ1 A;  2CM8 A;  3ZM3 A;  2FH7 A;  3RGQ A;  4ZI4 A;  3N2A A;  3S3K A;  5BZX A;  3V0J A;  1JBW A;  1Q6N A;  1AAX A;  2H03 A;  2I3R A;  4WOH A;  4GRY A;  2VEV A;  2GCB A;  1EEH A;  3QCB A;  5GTJ A;  5KA9 A;  3O4T A;  4RHG A;  5KA4 A;  1LYV A;  1NL9 A;  1U24 A;  5A5F A;  2J16 A;  2WGP A;  1X24 A;  1O5Z A;  2I6I A;  5KA8 A;  2F71 A;  1M3G A;  2UAG A;  4JMJ A;  4ZIY A;  2Y1O A;  3OMH A;  2JFH A;  4QBE A;  3MOZ A;  1W7K A;  1G1G A;  1ZCL A;  2F6T A;  2I6O A;  1ONZ A;  3O4U A;  1E8C A;  3NRS A;  4GRZ A;  2PQ5 A;  3D42 A;  2PA5 A;  3H2X A;  2NTA A;  2I6M A;  4DGP A;  1OHE A;  3I80 A;  2F6W A;  2SHP A;  1V3A A;  1T48 A;  4HRF A;  3ZM0 A;  1L8K A;  2VTD A;  4CVL A;  4D3P A;  2HNP A;  1J4X A;  1NWL A;  2I6J A;  1NNY A;  3D1O A;  2B07 A;  2YDU A;  1GG4 A;  1G7G A;  4RDD A;  3AWF A; 
#chains in the Genus database with same CATH homology
 4MBB A;  2C7S A;  4S0G A;  5KA1 A;  1YTW A;  4JNB A;  1RXD A;  4GE2 A;  4DGX A;  3ZM2 A;  2CMA A;  2CM7 A;  3RO1 A;  2QBR A;  1XXP A;  3M4U A;  1YFO A;  1C86 A;  2HXP A;  4GFV A;  1I9S A;  1NWE A;  1C84 A;  1YGU A;  2E0T A;  4J51 A;  4OHI A;  1C88 A;  1FPR A;  1Q6M A;  5BUG A;  2HCM A;  2I4H A;  3QCL A;  3QKP A;  1U26 A;  3D1H A;  1R6H A;  5KAA A;  3A5J A;  3V0E A;  2B4U A;  1SUG A;  3QCM A;  1PYN A;  1G1H A;  1NO6 A;  3S3H A;  4H1O A;  1YGR A;  2FJN A;  1XM2 A;  2BV5 A;  3MMJ A;  2A3K A;  4KYQ A;  5MMZ B;  2Q47 A;  4GWF A;  4IKC A;  5KA0 A;  1MKP A;  2HC1 A;  4D3Q A;  5EHR A;  5I6V A;  1NZ7 A;  1PA9 A;  2VEU A;  1ZCK A;  1VHR A;  2I3U A;  2BGE A;  3N0A A;  1BZJ A;  4ZN5 A;  1EEO A;  1C85 A;  3NME A;  2HC2 A;  3GXH A;  2VEW A;  5KA3 A;  4OHE A;  4QBW A;  1YPT A;  1Q6T A;  2DXP A;  4KI9 A;  2P6X A;  1OEO X;  3PS5 A;  2CMC A;  1EEN A;  3QCF A;  3AWE A;  2BIJ A;  1YWF A;  1BZC A;  3D9C A;  4HJP A;  1PA1 A;  4WU2 A;  4JBC A;  3CWE A;  1OET A;  2HVL A;  2OC3 A;  3S4O A;  2NZ6 A;  5KA2 A;  1JF7 A;  1PTY A;  2ZMM A;  2CNH A;  1ZZW A;  5KAB A;  4OHL A;  1OHD A;  2Q05 A;  5IBM A;  2I5X A;  3A5K A;  3F99 A;  1XXV A;  4GE5 A;  2F6Z A;  3LJ8 A;  2M3V A;  1T49 A;  1PTV A;  2QBS A;  4NWG A;  1OEU A;  5KA7 A;  3D1Q A;  2F46 A;  2P4D A;  2C46 A;  5LXQ B;  5BZZ A;  2CNG A;  1Q6S A;  2GP0 A;  4I8N A;  2A8B A;  3QCN A;  1G1F A;  4BPC A;  2MBC A;  3QKQ A;  4ERC A;  1P15 A;  3ZM1 A;  2JJD A;  2PI7 A;  3BLT A;  3V0G A;  1ECV A;  1ZC0 A;  1PXH A;  2B49 A;  5K9W A;  4YR8 B;  3QCC A;  2RF6 A;  3EZZ A;  1WAX A;  5M43 A;  2GJT A;  2I4E A;  3GXG A;  5J8R A;  2QDP A;  3O5X A;  1C83 A;  2Y96 A;  2CJZ A;  3BLU A;  4QUM A;  5AWX A;  3AWG A;  2H4V A;  1Q6J A;  1KAK A;  1XBO A;  2I4G A;  2H04 A;  2R0B A;  3EB1 A;  4H34 A;  1PH0 A;  3SME A;  2QCT A;  1QXK A;  1YTS A;  5K22 A;  1YN9 A;  3V0I A;  2OOQ A;  4YAA A;  1OES A;  4ZRT A;  2G59 A;  2PT0 A;  4KYR A;  2J17 A;  2PBN A;  1OHC A;  2F6Y A;  2NLK A;  2CM2 A;  3EU0 A;  2OUD A;  4AZ1 A;  3U96 A;  4OHD A;  2ZN7 A;  4Y2E A;  2HB1 A;  4RH9 A;  1OEV A;  4QUN A;  4R0T A;  3ZMQ A;  1G4W R;  1C87 A;  2AHS A;  3EAX A;  5K23 A;  5KAC A;  2FJM A;  3SR9 A;  1A5Y A;  3BRH A;  4WTY A;  3BM8 A;  2I75 A;  2B4P A;  2I6P A;  2NT7 A;  3B7O A;  2GWO A;  3V0F A;  1T4J A;  2QBP A;  4NND A;  2B3O A;  2H4K A;  3MOW A;  3QCI A;  2CNF A;  1G4U S;  4RI5 A;  4NYH A;  4PVG A;  1Q6P A;  2QDM A;  2Y2F A;  1RPM A;  5K9V A;  5KAD A;  2I42 A;  2B4O A;  3D44 A;  1YZ4 A;  3S3F A;  4TVV A;  4ICZ A;  4Z6B A;  1LAR A;  2OZ5 A;  1G7F A;  3V0H A;  4OHH A;  3I7Z A;  3F81 A;  1LQF A;  3S4E A;  4GE6 A;  1WRM A;  3ZMP A;  3ZV2 A;  3QCK A;  2F70 A;  1XRI A;  2F6V A;  2QBQ A;  4NWF A;  2H02 A;  1ONY A;  2CNI A;  2F6F A;  4R0S A;  5IBS A;  3OLR A;  1L8G A;  3O4S A;  2CMB A;  3CM3 A;  1YTN A;  3QCE A;  1BZH A;  3F9B A;  2VEY A;  4HJQ A;  5EHP A;  2NV5 A;  2NT2 A;  3RGO A;  4QAP A;  1GFY A;  2CFV A;  1Q1M A;  1U25 A;  2BGD A;  5HDE A;  2QEP A;  2I1Y A;  4B04 A;  4RH5 A;  4BJO A;  1I57 A;  2J16 B;  3QCG A;  3F9A A;  2B4S A;  4Y14 A;  3F41 A;  2G6Z A;  4QAH A;  1JLN A;  1D5R A;  3O3L A;  4NX8 A;  4RKK A;  1FPZ A;  3EMU A;  4GFU A;  4GS0 A;  3S3E A;  1WCH A;  4D3R A;  3QCD A;  3I36 A;  2PSZ A;  1GWZ A;  2BZL A;  2QCJ A;  2ESB A;  5K24 A;  1OEM X;  4JMK A;  1QZ0 A;  1I9T A;  5K25 A;  4RI4 A;  1PTT A;  5BX1 A;  2AZR A;  3RZ2 A;  2CM3 A;  2HNQ A;  4R30 A;  2QDC A;  2HY3 A;  4PYH A;  1PTU A;  3V0D A;  4WU3 A;  1KAV A;  3QCH A;  2IMG A;  2CNE A;  2VEX A;  2H4G A;  3QCJ A;  1FQ1 A;  2CM8 A;  3ZM3 A;  2FH7 A;  3RGQ A;  4ZI4 A;  3S3K A;  5BZX A;  3V0J A;  1Q6N A;  1AAX A;  2H03 A;  2I3R A;  4WOH A;  4GRY A;  2VEV A;  5GTJ A;  3QCB A;  5KA9 A;  3O4T A;  4RHG A;  5KA4 A;  1LYV A;  1NL9 A;  1U24 A;  2J16 A;  2WGP A;  1X24 A;  2I6I A;  5KA8 A;  2F71 A;  1M3G A;  4JMJ A;  3OMH A;  4QBE A;  3MOZ A;  1ZCL A;  1G1G A;  2F6T A;  2I6O A;  1ONZ A;  3O4U A;  4GRZ A;  2PQ5 A;  3D42 A;  2PA5 A;  3H2X A;  2NTA A;  2I6M A;  4DGP A;  1OHE A;  3I80 A;  2F6W A;  2SHP A;  1V3A A;  1T48 A;  4HRF A;  3ZM0 A;  1L8K A;  4D3P A;  2HNP A;  1J4X A;  1NWL A;  2I6J A;  1NNY A;  3D1O A;  2B07 A;  2YDU A;  1G7G A;  4RDD A;  3AWF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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