2QBPA

Crystal structure of ptp1b-inhibitor complex
Total Genus 97
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
97
sequence length
297
structure length
297
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Tyrosine-protein phosphatase non-receptor type 1
total genus 97
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2007-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2qbpA00
1C83A 1OHCA 2B3OA 3ZMQA 2Y2FA 1QXKA 1NO6A 2QDPA 1OEMX 3SMEA 2H4GA 5KA0A 2CMCA 3BM8A 4H1OA 3A5JA 1V3AA 2QDCA 4QBEA 2MBCA 2A8BA 5K9VA 1ZCKA 2F6TA 2I3UA 3BLUA 1PXHA 4QAPA 4D3QA 5M43A 2PI7A 4OHDA 2ESBA 2HB1A 3O3LA 1Q1MA 2CNHA 2PA5A 4HJPA 4R30A 1G7GA 1QZ0A 3O4SA 3S4EA 1JF7A 1SUGA 3A5KA 4GE6A 4GS0A 2CJZA 3GXHA 2I4HA 2HXPA 4PVGA 5KA2A 3H2XA 2CM2A 4Z6BA 2PSZA 1Q6PA 2HVLA 5KA9A 3RO1A 1PYNA 5IBMA 1PA1A 5HDEA 4AZ1A 1G1HA 1YGUA 3MMJA 1FQ1A 1PTUA 4I8NA 4KYRA 2B4OA 2NTAA 2H4VA 3F9BA 4BJOA 2CNEA 2GWOA 3I80A 5BZXA 1Q6NA 4DGPA 1C87A 2I4GA 1PTTA 1C85A 4WU2A 1KAVA 2NT2A 3GXGA 1YWFA 1C86A 2F71A 3S4OA 2I6OA 3D1OA 4QUMA 3ZM1A 2VEUA 2CNFA 5AWXA 3I36A 3CM3A 3RGQA 2HC2A 1NNYA 3V0DA 2YDUA 2JJDA 2I4EA 3QCJA 5KA3A 1OEVA 1XBOA 3OLRA 1T49A 2FJNA 4YAAA 4RHGA 5GTJA 1AAXA 4QAHA 3V0JA 5KAAA 4IKCA 3F9AA 4KYQA 4D3PA 2RF6A 1XXVA 1ONYA 3O4UA 2G59A 1PTVA 1T4JA 4QBWA 3ZMPA 3S3HA 2F6FA 2NZ6A 2I42A 3V0EA 3ZM3A 1FPZA 2BV5A 1EENA 3F41A 1Q6JA 2CM3A 5J8RA 3ZM0A 3QCBA 1WRMA 2NT7A 4MBBA 2FJMA 3V0IA 1LARA 2PT0A 3D1HA 3QCLA 1R6HA 1C88A 1L8GA 4RI4A 2VEYA 1T48A 4YR8B 2I75A 4NX8A 3EMUA 4GE5A 3ZV2A 4RH9A 1G1GA 4BPCA 2QCTA 1G4US 1ZC0A 2AHSA 3QCEA 4NYHA 1YN9A 2OUDA 3AWGA 4TVVA 5KA4A 1YGRA 2PBNA 3QKPA 1OEUA 1Q6TA 2I6PA 4R0TA 5LXQB 4WTYA 3S3KA 3QCNA 1XRIA 2DXPA 2F6ZA 1GWZA 1NWLA 2G6ZA 2ZMMA 3QCIA 4NNDA 1PA9A 1RXDA 1OEOX 1BZHA 2I6JA 5KABA 1P15A 3F81A 1I9SA 3OMHA 3U96A 4OHIA 4ERCA 4HRFA 3EAXA 5EHRA 5K24A 2I6MA 1JLNA 2F6WA 3O5XA 1XM2A 3F99A 4Y14A 3QKQA 1LYVA 2I5XA 3QCGA 3CWEA 2SHPA 4RH5A 5K25A 1WAXA 2OC3A 3QCCA 2A3KA 4GWFA 1U26A 1Q6SA 1YTWA 3V0FA 2F6VA 3D44A 5BZZA 2F6YA 1MKPA 2H02A 2J16B 2F70A 2M3VA 2CNGA 2B4PA 2H03A 4Y2EA 1VHRA 4GRZA 3V0HA 5I6VA 2NLKA 4JNBA 1D5RA 2IMGA 3D42A 2CFVA 4KI9A 3MOWA 2I1YA 1ECVA 2BGDA 2NV5A 3RGOA 1NWEA 5MMZB 4DGXA 1XXPA 3BLTA 1BZJA 4RI5A 2VEXA 3EZZA 4NWGA 5KA8A 4JMJA 4RDDA 2E0TA 1PTYA 2H04A 2BGEA 4R0SA 3LJ8A 1I9TA 2BZLA 1G4WR 1YTNA 4WOHA 4ZRTA 3M4UA 2Q47A 2QBRA 1EEOA 2GJTA 5IBSA 1L8KA 2HNQA 2Y96A 1PH0A 2P6XA 4B04A 3D9CA 5K9WA 5KADA 2QBQA 2QBPA 1FPRA 1C84A 2PQ5A 2QDMA 3V0GA 3I7ZA 2HC1A 4QUNA 3NMEA 1OHEA 4H34A 1ZCLA 3QCDA 2Q05A 3RZ2A 1WCHA 1OESA 2VEWA 5BX1A 5K23A 2OZ5A 4GFVA 4GRYA 4S0GA 3PS5A 1YFOA 2WGPA 2HCMA 4OHLA 2J17A 5K22A 1ZZWA 4ICZA 5KA7A 2H4KA 2F46A 4HJQA 2B49A 1NZ7A 1M3GA 1YTSA 2QCJA 5KACA 4J51A 3EU0A 3AWFA 4D3RA 1A5YA 3S3EA 2CM8A 1G7FA 2I6IA 3SR9A 3BRHA 2B4SA 1Q6MA 2R0BA 3QCHA 1NL9A 2I3RA 5BUGA 3B7OA 2HY3A 1GFYA 2CM7A 3QCMA 1YPTA 4ZI4A 2B07A 2HNPA 4RKKA 2J16A 2FH7A 5EHPA 2AZRA 4ZN5A 2B4UA 1LQFA 1G1FA 2ZN7A 3ZM2A 1RPMA 2C7SA 1I57A 1BZCA 2CMBA 2CMAA 3AWEA 2BIJA 2C46A 3N0AA 4WU3A 4OHHA 4OHEA 3O4TA 4JBCA 1ONZA 3D1QA 5KA1A 1U24A 2VEVA 1OHDA 3EB1A 1YZ4A 1U25A 1X24A 2GP0A 3QCFA 2QBSA 4GE2A 2P4DA 2CNIA 3S3FA 3MOZA 3QCKA 4GFUA 2QEPA 4NWFA 1OETA 2OOQA 1J4XA 1KAKA 4JMKA 4PYHA
chains in the Genus database with same CATH superfamily
1C83A 1OHCA 2B3OA 1GQQA 3ZMQA 2Y2FA 1QXKA 1NO6A 4BUBA 2QDPA 1OEMX 3SMEA 2H4GA 5KA0A 2CMCA 3BM8A 2AM2A 4H1OA 3A5JA 1V3AA 2QDCA 4QBEA 3MVNA 2MBCA 2A8BA 5K9VA 1ZCKA 2F6TA 2I3UA 3BLUA 1PXHA 4QAPA 4D3QA 5M43A 2PI7A 4OHDA 2ESBA 2HB1A 1P31A 3O3LA 2XJAA 1Q1MA 2CNHA 2PA5A 4HJPA 4R30A 1G7GA 1QZ0A 3O4SA 3S4EA 1JF7A 1SUGA 3A5KA 4GE6A 4GS0A 2UUOA 2CJZA 3GXHA 2I4HA 2HXPA 4PVGA 5KA2A 3H2XA 2Y66A 2CM2A 4Z6BA 2PSZA 1Q6PA 2HVLA 5KA9A 3RO1A 1PYNA 5IBMA 1PA1A 5HDEA 4AZ1A 1G1HA 1YGUA 3MMJA 1FQ1A 1PTUA 4I8NA 4KYRA 2B4OA 2NTAA 5A5FA 2H4VA 3F9BA 4BJOA 2JFGA 2CNEA 2XPCA 2GWOA 3I80A 5BZXA 1Q6NA 4DGPA 2JFHA 1C87A 4UAGA 2I4GA 4HV4A 1PTTA 1C85A 4WU2A 1KAVA 2NT2A 3GXGA 1YWFA 1C86A 2F71A 3S4OA 2I6OA 3D1OA 4QUMA 3ZM1A 2VEUA 2CNFA 5AWXA 3I36A 2GCBA 4CVLA 3CM3A 3RGQA 2HC2A 1NNYA 3V0DA 2YDUA 2JJDA 2I4EA 3QCJA 5KA3A 1OEVA 1XBOA 3OLRA 1T49A 1E0DA 2FJNA 4YAAA 2F00A 2GC6A 4RHGA 5GTJA 1AAXA 4QAHA 3V0JA 5KAAA 4IKCA 3F9AA 1EEHA 4KYQA 4D3PA 2RF6A 1XXVA 1ONYA 3O4UA 2G59A 1PTVA 1T4JA 1JBWA 4QBWA 3ZMPA 3S3HA 2F6FA 2NZ6A 2I42A 3V0EA 3ZL8A 3ZM3A 1FPZA 2BV5A 1EENA 3F41A 1Q6JA 2CM3A 5J8RA 3ZM0A 3QCBA 1WRMA 2NT7A 4MBBA 2FJMA 2AM1A 1LARA 3V0IA 2VTDA 2PT0A 3D1HA 3QCLA 1R6HA 1C88A 1L8GA 4RI4A 1UAGA 3HN7A 2VEYA 1T48A 3ZM5A 4YR8B 2I75A 4NX8A 3EMUA 4GE5A 3ZV2A 4RH9A 1G1GA 4BPCA 2QCTA 2WTZA 1G4US 1ZC0A 2AHSA 3QCEA 4NYHA 1YN9A 2OUDA 3AWGA 4TVVA 5KA4A 1P3DA 1YGRA 2PBNA 3QKPA 1OEUA 1Q6TA 2I6PA 4R0TA 5LXQB 4WTYA 3S3KA 3QCNA 1XRIA 2JFFA 2DXPA 2F6ZA 1GWZA 1NWLA 2Y67A 4QF5A 2G6ZA 2ZMMA 3QCIA 4NNDA 1PA9A 1RXDA 1OEOX 1BZHA 2I6JA 2Y68A 3PYZA 5KABA 1P15A 3F81A 1I9SA 3OMHA 3U96A 4OHIA 4ERCA 4HRFA 1JBVA 3EAXA 4C12A 5EHRA 5K24A 2I6MA 1JLNA 2F6WA 3O5XA 1XM2A 3F99A 4Y14A 3QKQA 1LYVA 2I5XA 2UUPA 1O5ZA 3QCGA 3CWEA 2SHPA 4RH5A 5K25A 1WAXA 2OC3A 2X5OA 3QCCA 2A3KA 4GWFA 1U26A 1Q6SA 1YTWA 3V0FA 2F6VA 3D44A 5BZZA 1W78A 2F6YA 1MKPA 2GCAA 2H02A 2J16B 2F70A 2M3VA 2CNGA 2B4PA 2H03A 4Y2EA 1VHRA 2VTEA 4GRZA 3V0HA 2WJPA 5I6VA 2NLKA 4JNBA 1D5RA 2IMGA 3D42A 2CFVA 4KI9A 4C13A 3MOWA 2I1YA 1ECVA 2BGDA 2NV5A 3RGOA 1NWEA 5MMZB 2VOSA 4DGXA 4ZIYA 1XXPA 3BLTA 1BZJA 4RI5A 2VEXA 3EZZA 4NWGA 5KA8A 4BUCA 4JMJA 4CVKA 3NRSA 4RDDA 2E0TA 1PTYA 2H04A 2BGEA 4R0SA 3LJ8A 1I9TA 2BZLA 3N2AA 1G4WR 1YTNA 4WOHA 4ZRTA 3M4UA 2Q47A 2QBRA 1EEOA 2GJTA 3QCZA 5IBSA 1L8KA 2HNQA 2Y96A 1PH0A 2P6XA 4B04A 1E8CA 3D9CA 5K9WA 5KADA 2QBQA 1J6UA 2QBPA 1FPRA 1C84A 2PQ5A 2QDMA 3V0GA 3I7ZA 2HC1A 4QUNA 3NMEA 1OHEA 4H34A 1ZCLA 3QCDA 2Q05A 3RZ2A 1WCHA 1OESA 2VEWA 5BX1A 1GQYA 5K23A 2OZ5A 4GFVA 4GRYA 4S0GA 3PS5A 1YFOA 2WGPA 2HCMA 4OHLA 4CVMA 2J17A 5K22A 4QDIA 1ZZWA 4ICZA 5KA7A 2H4KA 2F46A 4HJQA 2B49A 3ZM6A 1NZ7A 1M3GA 1YTSA 2QCJA 5KACA 4J51A 3EU0A 3AWFA 4D3RA 1A5YA 3S3EA 2CM8A 1GG4A 1G7FA 2I6IA 3SR9A 3BRHA 1FGSA 2B4SA 1Q6MA 2R0BA 2VORA 3UAGA 3QCHA 1NL9A 2I3RA 2Y1OA 3B7OA 5BUGA 2HY3A 1GFYA 2CM7A 3QCMA 1YPTA 4ZI4A 2B07A 2HNPA 4RKKA 5A5EA 2J16A 2FH7A 5EHPA 1W7KA 2AZRA 4ZN5A 2B4UA 1LQFA 1G1FA 2ZN7A 3ZM2A 1RPMA 2C7SA 1I57A 1BZCA 2CMBA 2CMAA 3AWEA 2BIJA 2C46A 3N0AA 2GC5A 4WU3A 4OHHA 4OHEA 3O4TA 4JBCA 1ONZA 3D1QA 5KA1A 1U24A 2VEVA 1OHDA 2UAGA 3EB1A 1YZ4A 1U25A 1X24A 2GP0A 3QCFA 2QBSA 4GE2A 3LK7A 2P4DA 2CNIA 3S3FA 3MOZA 3QCKA 4GFUA 2QEPA 4NWFA 1OETA 2OOQA 1J4XA 1KAKA 4JMKA 4PYHA
chains in the Genus database with same CATH topology
1C83A 1OHCA 2B3OA 3ZMQA 2Y2FA 1QXKA 1NO6A 2QDPA 1OEMX 3SMEA 2H4GA 5KA0A 2CMCA 3BM8A 4H1OA 3A5JA 1V3AA 2QDCA 4QBEA 2MBCA 2A8BA 5K9VA 1ZCKA 2F6TA 2I3UA 3BLUA 1PXHA 4QAPA 4D3QA 5M43A 2PI7A 4OHDA 2ESBA 2HB1A 3O3LA 1Q1MA 2CNHA 2PA5A 4HJPA 4R30A 1G7GA 1QZ0A 3O4SA 3S4EA 1JF7A 1SUGA 3A5KA 4GE6A 4GS0A 2CJZA 3GXHA 2I4HA 2HXPA 4PVGA 5KA2A 3H2XA 2CM2A 4Z6BA 2PSZA 1Q6PA 2HVLA 5KA9A 3RO1A 1PYNA 5IBMA 1PA1A 5HDEA 4AZ1A 1G1HA 1YGUA 3MMJA 1FQ1A 1PTUA 4I8NA 4KYRA 2B4OA 2NTAA 2H4VA 3F9BA 4BJOA 2CNEA 2GWOA 3I80A 5BZXA 1Q6NA 4DGPA 1C87A 2I4GA 1PTTA 1C85A 4WU2A 1KAVA 2NT2A 3GXGA 1YWFA 1C86A 2F71A 3S4OA 2I6OA 3D1OA 4QUMA 3ZM1A 2VEUA 2CNFA 5AWXA 3I36A 3CM3A 3RGQA 2HC2A 1NNYA 3V0DA 2YDUA 2JJDA 2I4EA 3QCJA 5KA3A 1OEVA 1XBOA 3OLRA 1T49A 2FJNA 4YAAA 4RHGA 5GTJA 1AAXA 4QAHA 3V0JA 5KAAA 4IKCA 3F9AA 4KYQA 4D3PA 2RF6A 1XXVA 1ONYA 3O4UA 2G59A 1PTVA 1T4JA 4QBWA 3ZMPA 3S3HA 2F6FA 2NZ6A 2I42A 3V0EA 3ZM3A 1FPZA 2BV5A 1EENA 3F41A 1Q6JA 2CM3A 5J8RA 3ZM0A 3QCBA 1WRMA 2NT7A 4MBBA 2FJMA 3V0IA 1LARA 2PT0A 3D1HA 3QCLA 1R6HA 1C88A 1L8GA 4RI4A 2VEYA 1T48A 4YR8B 2I75A 4NX8A 3EMUA 4GE5A 3ZV2A 4RH9A 1G1GA 4BPCA 2QCTA 1G4US 1ZC0A 2AHSA 3QCEA 4NYHA 1YN9A 2OUDA 3AWGA 4TVVA 5KA4A 1YGRA 2PBNA 3QKPA 1OEUA 1Q6TA 2I6PA 4R0TA 5LXQB 4WTYA 3S3KA 3QCNA 1XRIA 2DXPA 2F6ZA 1GWZA 1NWLA 2G6ZA 2ZMMA 3QCIA 4NNDA 1PA9A 1RXDA 1OEOX 1BZHA 2I6JA 5KABA 1P15A 3F81A 1I9SA 3OMHA 3U96A 4OHIA 4ERCA 4HRFA 3EAXA 5EHRA 5K24A 2I6MA 1JLNA 2F6WA 3O5XA 1XM2A 3F99A 4Y14A 3QKQA 1LYVA 2I5XA 3QCGA 3CWEA 2SHPA 4RH5A 5K25A 1WAXA 2OC3A 3QCCA 2A3KA 4GWFA 1U26A 1Q6SA 1YTWA 3V0FA 2F6VA 3D44A 5BZZA 2F6YA 1MKPA 2H02A 2J16B 2F70A 2M3VA 2CNGA 2B4PA 2H03A 4Y2EA 1VHRA 4GRZA 3V0HA 5I6VA 2NLKA 4JNBA 1D5RA 2IMGA 3D42A 2CFVA 4KI9A 3MOWA 2I1YA 1ECVA 2BGDA 2NV5A 3RGOA 1NWEA 5MMZB 4DGXA 1XXPA 3BLTA 1BZJA 4RI5A 2VEXA 3EZZA 4NWGA 5KA8A 4JMJA 4RDDA 2E0TA 1PTYA 2H04A 2BGEA 4R0SA 3LJ8A 1I9TA 2BZLA 1G4WR 1YTNA 4WOHA 4ZRTA 3M4UA 2Q47A 2QBRA 1EEOA 2GJTA 5IBSA 1L8KA 2HNQA 2Y96A 1PH0A 2P6XA 4B04A 3D9CA 5K9WA 5KADA 2QBQA 2QBPA 1FPRA 1C84A 2PQ5A 2QDMA 3V0GA 3I7ZA 2HC1A 4QUNA 3NMEA 1OHEA 4H34A 1ZCLA 3QCDA 2Q05A 3RZ2A 1WCHA 1OESA 2VEWA 5BX1A 5K23A 2OZ5A 4GFVA 4GRYA 4S0GA 3PS5A 1YFOA 2WGPA 2HCMA 4OHLA 2J17A 5K22A 1ZZWA 4ICZA 5KA7A 2H4KA 2F46A 4HJQA 2B49A 1NZ7A 1M3GA 1YTSA 2QCJA 5KACA 4J51A 3EU0A 3AWFA 4D3RA 1A5YA 3S3EA 2CM8A 1G7FA 2I6IA 3SR9A 3BRHA 2B4SA 1Q6MA 2R0BA 3QCHA 1NL9A 2I3RA 5BUGA 3B7OA 2HY3A 1GFYA 2CM7A 3QCMA 1YPTA 4ZI4A 2B07A 2HNPA 4RKKA 2J16A 2FH7A 5EHPA 2AZRA 4ZN5A 2B4UA 1LQFA 1G1FA 2ZN7A 3ZM2A 1RPMA 2C7SA 1I57A 1BZCA 2CMBA 2CMAA 3AWEA 2BIJA 2C46A 3N0AA 4WU3A 4OHHA 4OHEA 3O4TA 4JBCA 1ONZA 3D1QA 5KA1A 1U24A 2VEVA 1OHDA 3EB1A 1YZ4A 1U25A 1X24A 2GP0A 3QCFA 2QBSA 4GE2A 2P4DA 2CNIA 3S3FA 3MOZA 3QCKA 4GFUA 2QEPA 4NWFA 1OETA 2OOQA 1J4XA 1KAKA 4JMKA 4PYHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C83 A;  1OHC A;  2B3O A;  3ZMQ A;  2Y2F A;  1QXK A;  1NO6 A;  2QDP A;  1OEM X;  3SME A;  2H4G A;  5KA0 A;  2CMC A;  3BM8 A;  4H1O A;  3A5J A;  1V3A A;  2QDC A;  4QBE A;  2MBC A;  2A8B A;  5K9V A;  1ZCK A;  2F6T A;  2I3U A;  3BLU A;  1PXH A;  4QAP A;  4D3Q A;  5M43 A;  2PI7 A;  4OHD A;  2ESB A;  2HB1 A;  3O3L A;  1Q1M A;  2CNH A;  2PA5 A;  4HJP A;  4R30 A;  1G7G A;  1QZ0 A;  3O4S A;  3S4E A;  1JF7 A;  1SUG A;  3A5K A;  4GE6 A;  4GS0 A;  2CJZ A;  3GXH A;  2I4H A;  2HXP A;  4PVG A;  5KA2 A;  3H2X A;  2CM2 A;  4Z6B A;  2PSZ A;  1Q6P A;  2HVL A;  5KA9 A;  3RO1 A;  1PYN A;  5IBM A;  1PA1 A;  5HDE A;  4AZ1 A;  1G1H A;  1YGU A;  3MMJ A;  1FQ1 A;  1PTU A;  4I8N A;  4KYR A;  2B4O A;  2NTA A;  2H4V A;  3F9B A;  4BJO A;  2CNE A;  2GWO A;  3I80 A;  5BZX A;  1Q6N A;  4DGP A;  1C87 A;  2I4G A;  1PTT A;  1C85 A;  4WU2 A;  1KAV A;  2NT2 A;  3GXG A;  1YWF A;  1C86 A;  2F71 A;  3S4O A;  2I6O A;  3D1O A;  4QUM A;  3ZM1 A;  2VEU A;  2CNF A;  5AWX A;  3I36 A;  3CM3 A;  3RGQ A;  2HC2 A;  1NNY A;  3V0D A;  2YDU A;  2JJD A;  2I4E A;  3QCJ A;  5KA3 A;  1OEV A;  1XBO A;  3OLR A;  1T49 A;  2FJN A;  4YAA A;  4RHG A;  5GTJ A;  1AAX A;  4QAH A;  3V0J A;  5KAA A;  4IKC A;  3F9A A;  4KYQ A;  4D3P A;  2RF6 A;  1XXV A;  1ONY A;  3O4U A;  2G59 A;  1PTV A;  1T4J A;  4QBW A;  3ZMP A;  3S3H A;  2F6F A;  2NZ6 A;  2I42 A;  3V0E A;  3ZM3 A;  1FPZ A;  2BV5 A;  1EEN A;  3F41 A;  1Q6J A;  2CM3 A;  5J8R A;  3ZM0 A;  3QCB A;  1WRM A;  2NT7 A;  4MBB A;  2FJM A;  3V0I A;  1LAR A;  2PT0 A;  3D1H A;  3QCL A;  1R6H A;  1C88 A;  1L8G A;  4RI4 A;  2VEY A;  1T48 A;  4YR8 B;  2I75 A;  4NX8 A;  3EMU A;  4GE5 A;  3ZV2 A;  4RH9 A;  1G1G A;  4BPC A;  2QCT A;  1G4U S;  1ZC0 A;  2AHS A;  3QCE A;  4NYH A;  1YN9 A;  2OUD A;  3AWG A;  4TVV A;  5KA4 A;  1YGR A;  2PBN A;  3QKP A;  1OEU A;  1Q6T A;  2I6P A;  4R0T A;  5LXQ B;  4WTY A;  3S3K A;  3QCN A;  1XRI A;  2DXP A;  2F6Z A;  1GWZ A;  1NWL A;  2G6Z A;  2ZMM A;  3QCI A;  4NND A;  1PA9 A;  1RXD A;  1OEO X;  1BZH A;  2I6J A;  5KAB A;  1P15 A;  3F81 A;  1I9S A;  3OMH A;  3U96 A;  4OHI A;  4ERC A;  4HRF A;  3EAX A;  5EHR A;  5K24 A;  2I6M A;  1JLN A;  2F6W A;  3O5X A;  1XM2 A;  3F99 A;  4Y14 A;  3QKQ A;  1LYV A;  2I5X A;  3QCG A;  3CWE A;  2SHP A;  4RH5 A;  5K25 A;  1WAX A;  2OC3 A;  3QCC A;  2A3K A;  4GWF A;  1U26 A;  1Q6S A;  1YTW A;  3V0F A;  2F6V A;  3D44 A;  5BZZ A;  2F6Y A;  1MKP A;  2H02 A;  2J16 B;  2F70 A;  2M3V A;  2CNG A;  2B4P A;  2H03 A;  4Y2E A;  1VHR A;  4GRZ A;  3V0H A;  5I6V A;  2NLK A;  4JNB A;  1D5R A;  2IMG A;  3D42 A;  2CFV A;  4KI9 A;  3MOW A;  2I1Y A;  1ECV A;  2BGD A;  2NV5 A;  3RGO A;  1NWE A;  5MMZ B;  4DGX A;  1XXP A;  3BLT A;  1BZJ A;  4RI5 A;  2VEX A;  3EZZ A;  4NWG A;  5KA8 A;  4JMJ A;  4RDD A;  2E0T A;  1PTY A;  2H04 A;  2BGE A;  4R0S A;  3LJ8 A;  1I9T A;  2BZL A;  1G4W R;  1YTN A;  4WOH A;  4ZRT A;  3M4U A;  2Q47 A;  2QBR A;  1EEO A;  2GJT A;  5IBS A;  1L8K A;  2HNQ A;  2Y96 A;  1PH0 A;  2P6X A;  4B04 A;  3D9C A;  5K9W A;  5KAD A;  2QBQ A;  2QBP A;  1FPR A;  1C84 A;  2PQ5 A;  2QDM A;  3V0G A;  3I7Z A;  2HC1 A;  4QUN A;  3NME A;  1OHE A;  4H34 A;  1ZCL A;  3QCD A;  2Q05 A;  3RZ2 A;  1WCH A;  1OES A;  2VEW A;  5BX1 A;  5K23 A;  2OZ5 A;  4GFV A;  4GRY A;  4S0G A;  3PS5 A;  1YFO A;  2WGP A;  2HCM A;  4OHL A;  2J17 A;  5K22 A;  1ZZW A;  4ICZ A;  5KA7 A;  2H4K A;  2F46 A;  4HJQ A;  2B49 A;  1NZ7 A;  1M3G A;  1YTS A;  2QCJ A;  5KAC A;  4J51 A;  3EU0 A;  3AWF A;  4D3R A;  1A5Y A;  3S3E A;  2CM8 A;  1G7F A;  2I6I A;  3SR9 A;  3BRH A;  2B4S A;  1Q6M A;  2R0B A;  3QCH A;  1NL9 A;  2I3R A;  5BUG A;  3B7O A;  2HY3 A;  1GFY A;  2CM7 A;  3QCM A;  1YPT A;  4ZI4 A;  2B07 A;  2HNP A;  4RKK A;  2J16 A;  2FH7 A;  5EHP A;  2AZR A;  4ZN5 A;  2B4U A;  1LQF A;  1G1F A;  2ZN7 A;  3ZM2 A;  1RPM A;  2C7S A;  1I57 A;  1BZC A;  2CMB A;  2CMA A;  3AWE A;  2BIJ A;  2C46 A;  3N0A A;  4WU3 A;  4OHH A;  4OHE A;  3O4T A;  4JBC A;  1ONZ A;  3D1Q A;  5KA1 A;  1U24 A;  2VEV A;  1OHD A;  3EB1 A;  1YZ4 A;  1U25 A;  1X24 A;  2GP0 A;  3QCF A;  2QBS A;  4GE2 A;  2P4D A;  2CNI A;  3S3F A;  3MOZ A;  3QCK A;  4GFU A;  2QEP A;  4NWF A;  1OET A;  2OOQ A;  1J4X A;  1KAK A;  4JMK A;  4PYH A; 
#chains in the Genus database with same CATH topology
 1C83 A;  1OHC A;  2B3O A;  1GQQ A;  3ZMQ A;  2Y2F A;  1QXK A;  1NO6 A;  4BUB A;  2QDP A;  1OEM X;  3SME A;  2H4G A;  5KA0 A;  2CMC A;  3BM8 A;  2AM2 A;  4H1O A;  3A5J A;  1V3A A;  2QDC A;  4QBE A;  3MVN A;  2MBC A;  2A8B A;  5K9V A;  1ZCK A;  2F6T A;  2I3U A;  3BLU A;  1PXH A;  4QAP A;  4D3Q A;  5M43 A;  2PI7 A;  4OHD A;  2ESB A;  2HB1 A;  1P31 A;  3O3L A;  2XJA A;  1Q1M A;  2CNH A;  2PA5 A;  4HJP A;  4R30 A;  1G7G A;  1QZ0 A;  3O4S A;  3S4E A;  1JF7 A;  1SUG A;  3A5K A;  4GE6 A;  4GS0 A;  2UUO A;  2CJZ A;  3GXH A;  2I4H A;  2HXP A;  4PVG A;  5KA2 A;  3H2X A;  2Y66 A;  2CM2 A;  4Z6B A;  2PSZ A;  1Q6P A;  2HVL A;  5KA9 A;  3RO1 A;  1PYN A;  5IBM A;  1PA1 A;  5HDE A;  4AZ1 A;  1G1H A;  1YGU A;  3MMJ A;  1FQ1 A;  1PTU A;  4I8N A;  4KYR A;  2B4O A;  2NTA A;  5A5F A;  2H4V A;  3F9B A;  4BJO A;  2JFG A;  2CNE A;  2XPC A;  2GWO A;  3I80 A;  5BZX A;  1Q6N A;  4DGP A;  2JFH A;  1C87 A;  4UAG A;  2I4G A;  4HV4 A;  1PTT A;  1C85 A;  4WU2 A;  1KAV A;  2NT2 A;  3GXG A;  1YWF A;  1C86 A;  2F71 A;  3S4O A;  2I6O A;  3D1O A;  4QUM A;  3ZM1 A;  2VEU A;  2CNF A;  5AWX A;  3I36 A;  2GCB A;  4CVL A;  3CM3 A;  3RGQ A;  2HC2 A;  1NNY A;  3V0D A;  2YDU A;  2JJD A;  2I4E A;  3QCJ A;  5KA3 A;  1OEV A;  1XBO A;  3OLR A;  1T49 A;  1E0D A;  2FJN A;  4YAA A;  2F00 A;  2GC6 A;  4RHG A;  5GTJ A;  1AAX A;  4QAH A;  3V0J A;  5KAA A;  4IKC A;  3F9A A;  1EEH A;  4KYQ A;  4D3P A;  2RF6 A;  1XXV A;  1ONY A;  3O4U A;  2G59 A;  1PTV A;  1T4J A;  1JBW A;  4QBW A;  3ZMP A;  3S3H A;  2F6F A;  2NZ6 A;  2I42 A;  3V0E A;  3ZL8 A;  3ZM3 A;  1FPZ A;  2BV5 A;  1EEN A;  3F41 A;  1Q6J A;  2CM3 A;  5J8R A;  3ZM0 A;  3QCB A;  1WRM A;  2NT7 A;  4MBB A;  2FJM A;  2AM1 A;  1LAR A;  3V0I A;  2VTD A;  2PT0 A;  3D1H A;  3QCL A;  1R6H A;  1C88 A;  1L8G A;  4RI4 A;  1UAG A;  3HN7 A;  2VEY A;  1T48 A;  3ZM5 A;  4YR8 B;  2I75 A;  4NX8 A;  3EMU A;  4GE5 A;  3ZV2 A;  4RH9 A;  1G1G A;  4BPC A;  2QCT A;  2WTZ A;  1G4U S;  1ZC0 A;  2AHS A;  3QCE A;  4NYH A;  1YN9 A;  2OUD A;  3AWG A;  4TVV A;  5KA4 A;  1P3D A;  1YGR A;  2PBN A;  3QKP A;  1OEU A;  1Q6T A;  2I6P A;  4R0T A;  5LXQ B;  4WTY A;  3S3K A;  3QCN A;  1XRI A;  2JFF A;  2DXP A;  2F6Z A;  1GWZ A;  1NWL A;  2Y67 A;  4QF5 A;  2G6Z A;  2ZMM A;  3QCI A;  4NND A;  1PA9 A;  1RXD A;  1OEO X;  1BZH A;  2I6J A;  2Y68 A;  3PYZ A;  5KAB A;  1P15 A;  3F81 A;  1I9S A;  3OMH A;  3U96 A;  4OHI A;  4ERC A;  4HRF A;  1JBV A;  3EAX A;  4C12 A;  5EHR A;  5K24 A;  2I6M A;  1JLN A;  2F6W A;  3O5X A;  1XM2 A;  3F99 A;  4Y14 A;  3QKQ A;  1LYV A;  2I5X A;  2UUP A;  1O5Z A;  3QCG A;  3CWE A;  2SHP A;  4RH5 A;  5K25 A;  1WAX A;  2OC3 A;  2X5O A;  3QCC A;  2A3K A;  4GWF A;  1U26 A;  1Q6S A;  1YTW A;  3V0F A;  2F6V A;  3D44 A;  5BZZ A;  1W78 A;  2F6Y A;  1MKP A;  2GCA A;  2H02 A;  2J16 B;  2F70 A;  2M3V A;  2CNG A;  2B4P A;  2H03 A;  4Y2E A;  1VHR A;  2VTE A;  4GRZ A;  3V0H A;  2WJP A;  5I6V A;  2NLK A;  4JNB A;  1D5R A;  2IMG A;  3D42 A;  2CFV A;  4KI9 A;  4C13 A;  3MOW A;  2I1Y A;  1ECV A;  2BGD A;  2NV5 A;  3RGO A;  1NWE A;  5MMZ B;  2VOS A;  4DGX A;  4ZIY A;  1XXP A;  3BLT A;  1BZJ A;  4RI5 A;  2VEX A;  3EZZ A;  4NWG A;  5KA8 A;  4BUC A;  4JMJ A;  4CVK A;  3NRS A;  4RDD A;  2E0T A;  1PTY A;  2H04 A;  2BGE A;  4R0S A;  3LJ8 A;  1I9T A;  2BZL A;  3N2A A;  1G4W R;  1YTN A;  4WOH A;  4ZRT A;  3M4U A;  2Q47 A;  2QBR A;  1EEO A;  2GJT A;  3QCZ A;  5IBS A;  1L8K A;  2HNQ A;  2Y96 A;  1PH0 A;  2P6X A;  4B04 A;  1E8C A;  3D9C A;  5K9W A;  5KAD A;  2QBQ A;  1J6U A;  2QBP A;  1FPR A;  1C84 A;  2PQ5 A;  2QDM A;  3V0G A;  3I7Z A;  2HC1 A;  4QUN A;  3NME A;  1OHE A;  4H34 A;  1ZCL A;  3QCD A;  2Q05 A;  3RZ2 A;  1WCH A;  1OES A;  2VEW A;  5BX1 A;  1GQY A;  5K23 A;  2OZ5 A;  4GFV A;  4GRY A;  4S0G A;  3PS5 A;  1YFO A;  2WGP A;  2HCM A;  4OHL A;  4CVM A;  2J17 A;  5K22 A;  4QDI A;  1ZZW A;  4ICZ A;  5KA7 A;  2H4K A;  2F46 A;  4HJQ A;  2B49 A;  3ZM6 A;  1NZ7 A;  1M3G A;  1YTS A;  2QCJ A;  5KAC A;  4J51 A;  3EU0 A;  3AWF A;  4D3R A;  1A5Y A;  3S3E A;  2CM8 A;  1GG4 A;  1G7F A;  2I6I A;  3SR9 A;  3BRH A;  1FGS A;  2B4S A;  1Q6M A;  2R0B A;  2VOR A;  3UAG A;  3QCH A;  1NL9 A;  2I3R A;  2Y1O A;  3B7O A;  5BUG A;  2HY3 A;  1GFY A;  2CM7 A;  3QCM A;  1YPT A;  4ZI4 A;  2B07 A;  2HNP A;  4RKK A;  5A5E A;  2J16 A;  2FH7 A;  5EHP A;  1W7K A;  2AZR A;  4ZN5 A;  2B4U A;  1LQF A;  1G1F A;  2ZN7 A;  3ZM2 A;  1RPM A;  2C7S A;  1I57 A;  1BZC A;  2CMB A;  2CMA A;  3AWE A;  2BIJ A;  2C46 A;  3N0A A;  2GC5 A;  4WU3 A;  4OHH A;  4OHE A;  3O4T A;  4JBC A;  1ONZ A;  3D1Q A;  5KA1 A;  1U24 A;  2VEV A;  1OHD A;  2UAG A;  3EB1 A;  1YZ4 A;  1U25 A;  1X24 A;  2GP0 A;  3QCF A;  2QBS A;  4GE2 A;  3LK7 A;  2P4D A;  2CNI A;  3S3F A;  3MOZ A;  3QCK A;  4GFU A;  2QEP A;  4NWF A;  1OET A;  2OOQ A;  1J4X A;  1KAK A;  4JMK A;  4PYH A; 
#chains in the Genus database with same CATH homology
 1C83 A;  1OHC A;  2B3O A;  3ZMQ A;  2Y2F A;  1QXK A;  1NO6 A;  2QDP A;  1OEM X;  3SME A;  2H4G A;  5KA0 A;  2CMC A;  3BM8 A;  4H1O A;  3A5J A;  1V3A A;  2QDC A;  4QBE A;  2MBC A;  2A8B A;  5K9V A;  1ZCK A;  2F6T A;  2I3U A;  3BLU A;  1PXH A;  4QAP A;  4D3Q A;  5M43 A;  2PI7 A;  4OHD A;  2ESB A;  2HB1 A;  3O3L A;  1Q1M A;  2CNH A;  2PA5 A;  4HJP A;  4R30 A;  1G7G A;  1QZ0 A;  3O4S A;  3S4E A;  1JF7 A;  1SUG A;  3A5K A;  4GE6 A;  4GS0 A;  2CJZ A;  3GXH A;  2I4H A;  2HXP A;  4PVG A;  5KA2 A;  3H2X A;  2CM2 A;  4Z6B A;  2PSZ A;  1Q6P A;  2HVL A;  5KA9 A;  3RO1 A;  1PYN A;  5IBM A;  1PA1 A;  5HDE A;  4AZ1 A;  1G1H A;  1YGU A;  3MMJ A;  1FQ1 A;  1PTU A;  4I8N A;  4KYR A;  2B4O A;  2NTA A;  2H4V A;  3F9B A;  4BJO A;  2CNE A;  2GWO A;  3I80 A;  5BZX A;  1Q6N A;  4DGP A;  1C87 A;  2I4G A;  1PTT A;  1C85 A;  4WU2 A;  1KAV A;  2NT2 A;  3GXG A;  1YWF A;  1C86 A;  2F71 A;  3S4O A;  2I6O A;  3D1O A;  4QUM A;  3ZM1 A;  2VEU A;  2CNF A;  5AWX A;  3I36 A;  3CM3 A;  3RGQ A;  2HC2 A;  1NNY A;  3V0D A;  2YDU A;  2JJD A;  2I4E A;  3QCJ A;  5KA3 A;  1OEV A;  1XBO A;  3OLR A;  1T49 A;  2FJN A;  4YAA A;  4RHG A;  5GTJ A;  1AAX A;  4QAH A;  3V0J A;  5KAA A;  4IKC A;  3F9A A;  4KYQ A;  4D3P A;  2RF6 A;  1XXV A;  1ONY A;  3O4U A;  2G59 A;  1PTV A;  1T4J A;  4QBW A;  3ZMP A;  3S3H A;  2F6F A;  2NZ6 A;  2I42 A;  3V0E A;  3ZM3 A;  1FPZ A;  2BV5 A;  1EEN A;  3F41 A;  1Q6J A;  2CM3 A;  5J8R A;  3ZM0 A;  3QCB A;  1WRM A;  2NT7 A;  4MBB A;  2FJM A;  3V0I A;  1LAR A;  2PT0 A;  3D1H A;  3QCL A;  1R6H A;  1C88 A;  1L8G A;  4RI4 A;  2VEY A;  1T48 A;  4YR8 B;  2I75 A;  4NX8 A;  3EMU A;  4GE5 A;  3ZV2 A;  4RH9 A;  1G1G A;  4BPC A;  2QCT A;  1G4U S;  1ZC0 A;  2AHS A;  3QCE A;  4NYH A;  1YN9 A;  2OUD A;  3AWG A;  4TVV A;  5KA4 A;  1YGR A;  2PBN A;  3QKP A;  1OEU A;  1Q6T A;  2I6P A;  4R0T A;  5LXQ B;  4WTY A;  3S3K A;  3QCN A;  1XRI A;  2DXP A;  2F6Z A;  1GWZ A;  1NWL A;  2G6Z A;  2ZMM A;  3QCI A;  4NND A;  1PA9 A;  1RXD A;  1OEO X;  1BZH A;  2I6J A;  5KAB A;  1P15 A;  3F81 A;  1I9S A;  3OMH A;  3U96 A;  4OHI A;  4ERC A;  4HRF A;  3EAX A;  5EHR A;  5K24 A;  2I6M A;  1JLN A;  2F6W A;  3O5X A;  1XM2 A;  3F99 A;  4Y14 A;  3QKQ A;  1LYV A;  2I5X A;  3QCG A;  3CWE A;  2SHP A;  4RH5 A;  5K25 A;  1WAX A;  2OC3 A;  3QCC A;  2A3K A;  4GWF A;  1U26 A;  1Q6S A;  1YTW A;  3V0F A;  2F6V A;  3D44 A;  5BZZ A;  2F6Y A;  1MKP A;  2H02 A;  2J16 B;  2F70 A;  2M3V A;  2CNG A;  2B4P A;  2H03 A;  4Y2E A;  1VHR A;  4GRZ A;  3V0H A;  5I6V A;  2NLK A;  4JNB A;  1D5R A;  2IMG A;  3D42 A;  2CFV A;  4KI9 A;  3MOW A;  2I1Y A;  1ECV A;  2BGD A;  2NV5 A;  3RGO A;  1NWE A;  5MMZ B;  4DGX A;  1XXP A;  3BLT A;  1BZJ A;  4RI5 A;  2VEX A;  3EZZ A;  4NWG A;  5KA8 A;  4JMJ A;  4RDD A;  2E0T A;  1PTY A;  2H04 A;  2BGE A;  4R0S A;  3LJ8 A;  1I9T A;  2BZL A;  1G4W R;  1YTN A;  4WOH A;  4ZRT A;  3M4U A;  2Q47 A;  2QBR A;  1EEO A;  2GJT A;  5IBS A;  1L8K A;  2HNQ A;  2Y96 A;  1PH0 A;  2P6X A;  4B04 A;  3D9C A;  5K9W A;  5KAD A;  2QBQ A;  2QBP A;  1FPR A;  1C84 A;  2PQ5 A;  2QDM A;  3V0G A;  3I7Z A;  2HC1 A;  4QUN A;  3NME A;  1OHE A;  4H34 A;  1ZCL A;  3QCD A;  2Q05 A;  3RZ2 A;  1WCH A;  1OES A;  2VEW A;  5BX1 A;  5K23 A;  2OZ5 A;  4GFV A;  4GRY A;  4S0G A;  3PS5 A;  1YFO A;  2WGP A;  2HCM A;  4OHL A;  2J17 A;  5K22 A;  1ZZW A;  4ICZ A;  5KA7 A;  2H4K A;  2F46 A;  4HJQ A;  2B49 A;  1NZ7 A;  1M3G A;  1YTS A;  2QCJ A;  5KAC A;  4J51 A;  3EU0 A;  3AWF A;  4D3R A;  1A5Y A;  3S3E A;  2CM8 A;  1G7F A;  2I6I A;  3SR9 A;  3BRH A;  2B4S A;  1Q6M A;  2R0B A;  3QCH A;  1NL9 A;  2I3R A;  5BUG A;  3B7O A;  2HY3 A;  1GFY A;  2CM7 A;  3QCM A;  1YPT A;  4ZI4 A;  2B07 A;  2HNP A;  4RKK A;  2J16 A;  2FH7 A;  5EHP A;  2AZR A;  4ZN5 A;  2B4U A;  1LQF A;  1G1F A;  2ZN7 A;  3ZM2 A;  1RPM A;  2C7S A;  1I57 A;  1BZC A;  2CMB A;  2CMA A;  3AWE A;  2BIJ A;  2C46 A;  3N0A A;  4WU3 A;  4OHH A;  4OHE A;  3O4T A;  4JBC A;  1ONZ A;  3D1Q A;  5KA1 A;  1U24 A;  2VEV A;  1OHD A;  3EB1 A;  1YZ4 A;  1U25 A;  1X24 A;  2GP0 A;  3QCF A;  2QBS A;  4GE2 A;  2P4D A;  2CNI A;  3S3F A;  3MOZ A;  3QCK A;  4GFU A;  2QEP A;  4NWF A;  1OET A;  2OOQ A;  1J4X A;  1KAK A;  4JMK A;  4PYH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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