3ZM0A

Catalytic domain of human shp2
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
282
structure length
261
Chain Sequence
GAHMWEEFETLQYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
total genus 88
structure length 261
sequence length 282
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2013-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 3zm0A00
3CWEA 2ZN7A 2FH7A 1NNYA 3AWFA 1KAVA 2E0TA 4Z6BA 2HC1A 1V3AA 4GFVA 3GXHA 4JMJA 1I9TA 1YTNA 3S4EA 3NMEA 1T49A 5J8RA 1Q6TA 1QZ0A 1OHEA 3V0JA 1LYVA 4HJPA 2PA5A 4KI9A 4R0TA 5MMZB 3QCIA 1OEMX 3U96A 2F6TA 2PT0A 2VEVA 3ZM3A 1C87A 2CNGA 1EENA 1I57A 3QCNA 5LXQB 2BIJA 3H2XA 3QCJA 2Q05A 5I6VA 2BGEA 2QBRA 2B3OA 4RKKA 4R0SA 4RH9A 5KA0A 3D9CA 4I8NA 2CM2A 1Q6JA 4WTYA 2C7SA 2CMAA 2OUDA 2I4HA 1YPTA 2GWOA 2H4GA 2C46A 4OHEA 1XXVA 2SHPA 1P15A 4NNDA 2I4EA 4HRFA 4ICZA 1C83A 2NV5A 3O3LA 2JJDA 1OEOX 5KA3A 4MBBA 4DGPA 4YR8B 1YZ4A 1M3GA 2ESBA 5GTJA 2CM8A 4HJQA 2NLKA 5BZZA 1C86A 2HY3A 2CFVA 2Y96A 2QEPA 3SR9A 2NT2A 1ZCKA 2CM7A 4H34A 4R30A 2HC2A 3QCHA 2HCMA 3RO1A 4QUNA 2P4DA 1YN9A 3O5XA 1Q6NA 3QCEA 2P6XA 1JF7A 2F6YA 4JBCA 3ZM1A 2Y2FA 3QCMA 1AAXA 2CMCA 2HXPA 2PI7A 3ZM0A 4GS0A 2I42A 2HB1A 2I6JA 1PYNA 4QAPA 4OHIA 1OHDA 1NWEA 4GFUA 1R6HA 2B4UA 2FJMA 1YTWA 4GE5A 1WAXA 2DXPA 2I5XA 4NWGA 4J51A 1LARA 1BZJA 2J16A 5K24A 2H4VA 1GFYA 2I75A 3F41A 4GWFA 1OHCA 1NO6A 5BX1A 1OEVA 2OC3A 2GP0A 1PA1A 4QAHA 3CM3A 2J17A 5IBSA 3V0DA 1PH0A 5KA7A 3S3EA 1A5YA 3MMJA 1OEUA 2BGDA 1C85A 2VEUA 4WU2A 3ZMQA 1XXPA 1J4XA 2IMGA 3F9BA 4KYQA 1XRIA 1NWLA 2F6FA 2G6ZA 2F71A 1ZCLA 2A8BA 1PTYA 3QKQA 4WU3A 5KADA 2CMBA 1RXDA 4GRYA 3AWGA 3M4UA 3PS5A 2NT7A 4NWFA 1JLNA 2A3KA 5K23A 2CNIA 1NZ7A 1ONYA 3S3FA 2PBNA 2I6PA 1NL9A 2BZLA 2YDUA 2PSZA 1SUGA 3S3HA 2QBSA 5K25A 3B7OA 1G4US 4D3QA 2M3VA 2CM3A 3QCDA 2HNQA 2WGPA 1EEOA 5M43A 3EMUA 4H1OA 5AWXA 1YGUA 5KA9A 1YFOA 3EAXA 2I4GA 1ZC0A 4RI4A 5K22A 1ECVA 2HNPA 2H4KA 4KYRA 3ZV2A 1ZZWA 2J16B 1PTTA 3ZM2A 1G1FA 2AZRA 1T4JA 2QCTA 1Q1MA 2NTAA 1G7GA 2MBCA 1U24A 5KA2A 5KAAA 3D42A 2F6WA 4B04A 4ZI4A 1YTSA 2I3UA 4RH5A 2ZMMA 5KA4A 1ONZA 4QBEA 5KA1A 4RI5A 4QBWA 3V0FA 2OZ5A 4TVVA 3BM8A 2B4PA 1L8GA 4Y2EA 5BUGA 1BZHA 1C84A 1FQ1A 1LQFA 2NZ6A 3I36A 4JMKA 2QDMA 1G1HA 3I80A 2VEYA 5KABA 3AWEA 4ZN5A 4ZRTA 3QCLA 3QCFA 3O4TA 3QCKA 3EZZA 4BPCA 1G4WR 3QCCA 1XBOA 2G59A 3N0AA 1KAKA 1OESA 4NX8A 2R0BA 3D1OA 1RPMA 3V0IA 5IBMA 4IKCA 4BJOA 4OHLA 2F70A 2CJZA 2H04A 3D44A 3F9AA 1PXHA 3RZ2A 2H03A 2Q47A 3D1QA 1L8KA 3V0HA 3A5KA 4JNBA 1U26A 2RF6A 2H02A 3V0EA 2CNHA 2PQ5A 3QCGA 1PTUA 3SMEA 3MOWA 4D3PA 3O4UA 3BLTA 3OLRA 5KACA 2B4OA 2B4SA 4GRZA 3QKPA 2F46A 5EHRA 3EB1A 2CNEA 2QDPA 2I1YA 3ZMPA 2HVLA 2GJTA 1PA9A 3D1HA 5KA8A 4NYHA 1PTVA 1Q6SA 3EU0A 4DGXA 2I6MA 4Y14A 2VEWA 4YAAA 5K9VA 1VHRA 4GE2A 5K9WA 1G1GA 4GE6A 3S4OA 2F6VA 2OOQA 4WOHA 2VEXA 1C88A 4RHGA 4ERCA 5HDEA 1OETA 1BZCA 1Q6PA 4PYHA 3I7ZA 1YWFA 5BZXA 2QCJA 1D5RA 2B07A 2FJNA 4RDDA 1T48A 2AHSA 1X24A 1GWZA 1FPRA 4PVGA 3QCBA 1FPZA 2I3RA 4OHHA 3GXGA 5EHPA 4S0GA 3S3KA 1MKPA 1QXKA 2BV5A 3O4SA 4AZ1A 3F99A 1WCHA 2QBPA 2QDCA 1YGRA 3RGOA 3LJ8A 1WRMA 2I6OA 2QBQA 2I6IA 2F6ZA 1Q6MA 3BRHA 2B49A 1I9SA 3A5JA 4QUMA 3OMHA 1XM2A 1U25A 3RGQA 1G7FA 3BLUA 3MOZA 4D3RA 3V0GA 3F81A 2CNFA 4OHDA
chains in the Genus database with same CATH superfamily
3CWEA 2ZN7A 2FH7A 1NNYA 2JFFA 3AWFA 1KAVA 2E0TA 4Z6BA 2HC1A 1V3AA 4GFVA 3GXHA 4JMJA 1I9TA 4ZIYA 1YTNA 3S4EA 3NMEA 1T49A 5J8RA 1Q6TA 1QZ0A 1OHEA 3V0JA 1LYVA 4HJPA 2PA5A 3N2AA 4KI9A 4R0TA 5MMZB 3QCIA 1OEMX 3U96A 2WTZA 2F6TA 2PT0A 2VEVA 3ZM3A 1C87A 2CNGA 1EENA 1I57A 3QCNA 5LXQB 2BIJA 3H2XA 3QCJA 2Q05A 1E0DA 2Y67A 2F00A 2X5OA 4C12A 5I6VA 2BGEA 2QBRA 2B3OA 4RKKA 4R0SA 4RH9A 5KA0A 3D9CA 4I8NA 2CM2A 1Q6JA 3NRSA 2C7SA 4WTYA 2Y68A 2CMAA 2OUDA 2I4HA 1YPTA 2GWOA 2GC5A 1GQYA 2H4GA 2C46A 4OHEA 1XXVA 2SHPA 1P15A 4NNDA 2I4EA 4HRFA 4ICZA 1C83A 4QF5A 2NV5A 3O3LA 2JJDA 1OEOX 5KA3A 4MBBA 4DGPA 4YR8B 1YZ4A 1M3GA 2ESBA 5GTJA 2CM8A 2UUPA 4HJQA 1O5ZA 2NLKA 5BZZA 1C86A 2HY3A 2CFVA 2Y96A 2QEPA 3QCZA 3SR9A 2NT2A 1ZCKA 2CM7A 4H34A 4R30A 2HC2A 3QCHA 2HCMA 2VOSA 3RO1A 4QUNA 2P4DA 1YN9A 3O5XA 1Q6NA 3QCEA 2JFGA 2P6XA 1JF7A 1JBVA 2F6YA 4JBCA 3ZM1A 2Y2FA 3PYZA 3QCMA 1AAXA 2CMCA 4BUCA 2HXPA 2PI7A 3ZM0A 2AM1A 4GS0A 2I42A 2HB1A 2I6JA 1PYNA 4QAPA 4OHIA 1OHDA 1NWEA 4GFUA 1R6HA 2B4UA 2FJMA 4HV4A 1YTWA 4GE5A 1WAXA 2DXPA 2I5XA 4NWGA 4J51A 1LARA 1BZJA 2J16A 5K24A 2H4VA 1GFYA 2I75A 3F41A 4GWFA 1OHCA 1NO6A 5BX1A 1OEVA 2OC3A 2GP0A 1PA1A 2GC6A 1J6UA 4QAHA 3CM3A 2J17A 5IBSA 3V0DA 1PH0A 5KA7A 2XJAA 1UAGA 3S3EA 1A5YA 3MMJA 4CVLA 1OEUA 2BGDA 4UAGA 1JBWA 1C85A 2VEUA 4WU2A 3ZMQA 1XXPA 2GCAA 1J4XA 2IMGA 3F9BA 4KYQA 1XRIA 1NWLA 2F6FA 2G6ZA 2F71A 3ZM6A 1ZCLA 2A8BA 1PTYA 3QKQA 4WU3A 5KADA 2CMBA 1RXDA 4GRYA 3AWGA 3M4UA 4CVKA 2NT7A 3PS5A 4NWFA 1JLNA 2A3KA 5K23A 2CNIA 1NZ7A 1ONYA 3S3FA 2PBNA 2I6PA 3LK7A 1NL9A 2BZLA 2YDUA 3ZL8A 2PSZA 1SUGA 3S3HA 2QBSA 5K25A 3B7OA 1G4US 4D3QA 2M3VA 2CM3A 3QCDA 2HNQA 2WGPA 1EEOA 5M43A 3EMUA 4H1OA 5AWXA 1YGUA 5KA9A 1YFOA 3EAXA 2I4GA 1ZC0A 4RI4A 5K22A 1ECVA 2HNPA 2H4KA 4KYRA 3ZV2A 1ZZWA 2J16B 1PTTA 3MVNA 2XPCA 3ZM2A 1G1FA 2AZRA 1T4JA 2QCTA 1Q1MA 2NTAA 1G7GA 2MBCA 1U24A 2VTEA 5KA2A 5KAAA 3D42A 2F6WA 4B04A 4ZI4A 3HN7A 1YTSA 2AM2A 2I3UA 4RH5A 2ZMMA 5KA4A 1ONZA 4QBEA 5KA1A 4RI5A 4QBWA 4QDIA 3V0FA 2OZ5A 4TVVA 3BM8A 2B4PA 1L8GA 4Y2EA 5BUGA 1BZHA 4CVMA 1P31A 1C84A 1FQ1A 1LQFA 2NZ6A 3I36A 4JMKA 2QDMA 1G1HA 3I80A 2VEYA 5KABA 3AWEA 4ZN5A 4ZRTA 3QCLA 2Y66A 3QCFA 1W78A 4C13A 3O4TA 3QCKA 3EZZA 4BPCA 1G4WR 3QCCA 1XBOA 2G59A 2VORA 3N0AA 1KAKA 2VTDA 1OESA 4NX8A 2R0BA 2UAGA 3D1OA 1RPMA 3V0IA 5IBMA 4IKCA 4BJOA 4OHLA 2F70A 2CJZA 1GG4A 2H04A 3D44A 3F9AA 1PXHA 3RZ2A 2H03A 2Q47A 3D1QA 1L8KA 3V0HA 2Y1OA 3A5KA 4JNBA 1U26A 2RF6A 2H02A 3V0EA 2CNHA 2PQ5A 1GQQA 1EEHA 3QCGA 3UAGA 1PTUA 3SMEA 1E8CA 3MOWA 4D3PA 3O4UA 3BLTA 3OLRA 5KACA 2B4OA 2B4SA 4GRZA 3QKPA 2F46A 5EHRA 3EB1A 2CNEA 2QDPA 2I1YA 3ZMPA 2HVLA 2GJTA 1PA9A 3D1HA 5KA8A 4NYHA 1PTVA 1Q6SA 3EU0A 4DGXA 2I6MA 4Y14A 2VEWA 4YAAA 5K9VA 1VHRA 4GE2A 5K9WA 1G1GA 4GE6A 3S4OA 5A5FA 2F6VA 2OOQA 4WOHA 2VEXA 1FGSA 1C88A 4RHGA 4ERCA 5HDEA 1OETA 1BZCA 1Q6PA 2UUOA 4PYHA 3I7ZA 1YWFA 5BZXA 2QCJA 1D5RA 2B07A 2FJNA 4RDDA 1W7KA 1T48A 2AHSA 1X24A 1GWZA 2JFHA 1FPRA 4PVGA 3QCBA 1FPZA 2I3RA 4OHHA 3GXGA 5EHPA 4S0GA 3S3KA 1MKPA 1QXKA 2BV5A 3O4SA 4AZ1A 3F99A 1WCHA 4BUBA 2QBPA 2QDCA 1YGRA 3RGOA 3LJ8A 1WRMA 2I6OA 2QBQA 2I6IA 2GCBA 5A5EA 2F6ZA 1Q6MA 3BRHA 2B49A 1I9SA 3A5JA 4QUMA 3OMHA 1P3DA 1XM2A 1U25A 3RGQA 1G7FA 3ZM5A 3BLUA 3MOZA 4D3RA 3V0GA 3F81A 2CNFA 2WJPA 4OHDA
chains in the Genus database with same CATH topology
3CWEA 2ZN7A 2FH7A 1NNYA 3AWFA 1KAVA 2E0TA 4Z6BA 2HC1A 1V3AA 4GFVA 3GXHA 4JMJA 1I9TA 1YTNA 3S4EA 3NMEA 1T49A 5J8RA 1Q6TA 1QZ0A 1OHEA 3V0JA 1LYVA 4HJPA 2PA5A 4KI9A 4R0TA 5MMZB 3QCIA 1OEMX 3U96A 2F6TA 2PT0A 2VEVA 3ZM3A 1C87A 2CNGA 1EENA 1I57A 3QCNA 5LXQB 2BIJA 3H2XA 3QCJA 2Q05A 5I6VA 2BGEA 2QBRA 2B3OA 4RKKA 4R0SA 4RH9A 5KA0A 3D9CA 4I8NA 2CM2A 1Q6JA 4WTYA 2C7SA 2CMAA 2OUDA 2I4HA 1YPTA 2GWOA 2H4GA 2C46A 4OHEA 1XXVA 2SHPA 1P15A 4NNDA 2I4EA 4HRFA 4ICZA 1C83A 2NV5A 3O3LA 2JJDA 1OEOX 5KA3A 4MBBA 4DGPA 4YR8B 1YZ4A 1M3GA 2ESBA 5GTJA 2CM8A 4HJQA 2NLKA 5BZZA 1C86A 2HY3A 2CFVA 2Y96A 2QEPA 3SR9A 2NT2A 1ZCKA 2CM7A 4H34A 4R30A 2HC2A 3QCHA 2HCMA 3RO1A 4QUNA 2P4DA 1YN9A 3O5XA 1Q6NA 3QCEA 2P6XA 1JF7A 2F6YA 4JBCA 3ZM1A 2Y2FA 3QCMA 1AAXA 2CMCA 2HXPA 2PI7A 3ZM0A 4GS0A 2I42A 2HB1A 2I6JA 1PYNA 4QAPA 4OHIA 1OHDA 1NWEA 4GFUA 1R6HA 2B4UA 2FJMA 1YTWA 4GE5A 1WAXA 2DXPA 2I5XA 4NWGA 4J51A 1LARA 1BZJA 2J16A 5K24A 2H4VA 1GFYA 2I75A 3F41A 4GWFA 1OHCA 1NO6A 5BX1A 1OEVA 2OC3A 2GP0A 1PA1A 4QAHA 3CM3A 2J17A 5IBSA 3V0DA 1PH0A 5KA7A 3S3EA 1A5YA 3MMJA 1OEUA 2BGDA 1C85A 2VEUA 4WU2A 3ZMQA 1XXPA 1J4XA 2IMGA 3F9BA 4KYQA 1XRIA 1NWLA 2F6FA 2G6ZA 2F71A 1ZCLA 2A8BA 1PTYA 3QKQA 4WU3A 5KADA 2CMBA 1RXDA 4GRYA 3AWGA 3M4UA 3PS5A 2NT7A 4NWFA 1JLNA 2A3KA 5K23A 2CNIA 1NZ7A 1ONYA 3S3FA 2PBNA 2I6PA 1NL9A 2BZLA 2YDUA 2PSZA 1SUGA 3S3HA 2QBSA 5K25A 3B7OA 1G4US 4D3QA 2M3VA 2CM3A 3QCDA 2HNQA 2WGPA 1EEOA 5M43A 3EMUA 4H1OA 5AWXA 1YGUA 5KA9A 1YFOA 3EAXA 2I4GA 1ZC0A 4RI4A 5K22A 1ECVA 2HNPA 2H4KA 4KYRA 3ZV2A 1ZZWA 2J16B 1PTTA 3ZM2A 1G1FA 2AZRA 1T4JA 2QCTA 1Q1MA 2NTAA 1G7GA 2MBCA 1U24A 5KA2A 5KAAA 3D42A 2F6WA 4B04A 4ZI4A 1YTSA 2I3UA 4RH5A 2ZMMA 5KA4A 1ONZA 4QBEA 5KA1A 4RI5A 4QBWA 3V0FA 2OZ5A 4TVVA 3BM8A 2B4PA 1L8GA 4Y2EA 5BUGA 1BZHA 1C84A 1FQ1A 1LQFA 2NZ6A 3I36A 4JMKA 2QDMA 1G1HA 3I80A 2VEYA 5KABA 3AWEA 4ZN5A 4ZRTA 3QCLA 3QCFA 3O4TA 3QCKA 3EZZA 4BPCA 1G4WR 3QCCA 1XBOA 2G59A 3N0AA 1KAKA 1OESA 4NX8A 2R0BA 3D1OA 1RPMA 3V0IA 5IBMA 4IKCA 4BJOA 4OHLA 2F70A 2CJZA 2H04A 3D44A 3F9AA 1PXHA 3RZ2A 2H03A 2Q47A 3D1QA 1L8KA 3V0HA 3A5KA 4JNBA 1U26A 2RF6A 2H02A 3V0EA 2CNHA 2PQ5A 3QCGA 1PTUA 3SMEA 3MOWA 4D3PA 3O4UA 3BLTA 3OLRA 5KACA 2B4OA 2B4SA 4GRZA 3QKPA 2F46A 5EHRA 3EB1A 2CNEA 2QDPA 2I1YA 3ZMPA 2HVLA 2GJTA 1PA9A 3D1HA 5KA8A 4NYHA 1PTVA 1Q6SA 3EU0A 4DGXA 2I6MA 4Y14A 2VEWA 4YAAA 5K9VA 1VHRA 4GE2A 5K9WA 1G1GA 4GE6A 3S4OA 2F6VA 2OOQA 4WOHA 2VEXA 1C88A 4RHGA 4ERCA 5HDEA 1OETA 1BZCA 1Q6PA 4PYHA 3I7ZA 1YWFA 5BZXA 2QCJA 1D5RA 2B07A 2FJNA 4RDDA 1T48A 2AHSA 1X24A 1GWZA 1FPRA 4PVGA 3QCBA 1FPZA 2I3RA 4OHHA 3GXGA 5EHPA 4S0GA 3S3KA 1MKPA 1QXKA 2BV5A 3O4SA 4AZ1A 3F99A 1WCHA 2QBPA 2QDCA 1YGRA 3RGOA 3LJ8A 1WRMA 2I6OA 2QBQA 2I6IA 2F6ZA 1Q6MA 3BRHA 2B49A 1I9SA 3A5JA 4QUMA 3OMHA 1XM2A 1U25A 3RGQA 1G7FA 3BLUA 3MOZA 4D3RA 3V0GA 3F81A 2CNFA 4OHDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CWE A;  2ZN7 A;  2FH7 A;  1NNY A;  3AWF A;  1KAV A;  2E0T A;  4Z6B A;  2HC1 A;  1V3A A;  4GFV A;  3GXH A;  4JMJ A;  1I9T A;  1YTN A;  3S4E A;  3NME A;  1T49 A;  5J8R A;  1Q6T A;  1QZ0 A;  1OHE A;  3V0J A;  1LYV A;  4HJP A;  2PA5 A;  4KI9 A;  4R0T A;  5MMZ B;  3QCI A;  1OEM X;  3U96 A;  2F6T A;  2PT0 A;  2VEV A;  3ZM3 A;  1C87 A;  2CNG A;  1EEN A;  1I57 A;  3QCN A;  5LXQ B;  2BIJ A;  3H2X A;  3QCJ A;  2Q05 A;  5I6V A;  2BGE A;  2QBR A;  2B3O A;  4RKK A;  4R0S A;  4RH9 A;  5KA0 A;  3D9C A;  4I8N A;  2CM2 A;  1Q6J A;  4WTY A;  2C7S A;  2CMA A;  2OUD A;  2I4H A;  1YPT A;  2GWO A;  2H4G A;  2C46 A;  4OHE A;  1XXV A;  2SHP A;  1P15 A;  4NND A;  2I4E A;  4HRF A;  4ICZ A;  1C83 A;  2NV5 A;  3O3L A;  2JJD A;  1OEO X;  5KA3 A;  4MBB A;  4DGP A;  4YR8 B;  1YZ4 A;  1M3G A;  2ESB A;  5GTJ A;  2CM8 A;  4HJQ A;  2NLK A;  5BZZ A;  1C86 A;  2HY3 A;  2CFV A;  2Y96 A;  2QEP A;  3SR9 A;  2NT2 A;  1ZCK A;  2CM7 A;  4H34 A;  4R30 A;  2HC2 A;  3QCH A;  2HCM A;  3RO1 A;  4QUN A;  2P4D A;  1YN9 A;  3O5X A;  1Q6N A;  3QCE A;  2P6X A;  1JF7 A;  2F6Y A;  4JBC A;  3ZM1 A;  2Y2F A;  3QCM A;  1AAX A;  2CMC A;  2HXP A;  2PI7 A;  3ZM0 A;  4GS0 A;  2I42 A;  2HB1 A;  2I6J A;  1PYN A;  4QAP A;  4OHI A;  1OHD A;  1NWE A;  4GFU A;  1R6H A;  2B4U A;  2FJM A;  1YTW A;  4GE5 A;  1WAX A;  2DXP A;  2I5X A;  4NWG A;  4J51 A;  1LAR A;  1BZJ A;  2J16 A;  5K24 A;  2H4V A;  1GFY A;  2I75 A;  3F41 A;  4GWF A;  1OHC A;  1NO6 A;  5BX1 A;  1OEV A;  2OC3 A;  2GP0 A;  1PA1 A;  4QAH A;  3CM3 A;  2J17 A;  5IBS A;  3V0D A;  1PH0 A;  5KA7 A;  3S3E A;  1A5Y A;  3MMJ A;  1OEU A;  2BGD A;  1C85 A;  2VEU A;  4WU2 A;  3ZMQ A;  1XXP A;  1J4X A;  2IMG A;  3F9B A;  4KYQ A;  1XRI A;  1NWL A;  2F6F A;  2G6Z A;  2F71 A;  1ZCL A;  2A8B A;  1PTY A;  3QKQ A;  4WU3 A;  5KAD A;  2CMB A;  1RXD A;  4GRY A;  3AWG A;  3M4U A;  3PS5 A;  2NT7 A;  4NWF A;  1JLN A;  2A3K A;  5K23 A;  2CNI A;  1NZ7 A;  1ONY A;  3S3F A;  2PBN A;  2I6P A;  1NL9 A;  2BZL A;  2YDU A;  2PSZ A;  1SUG A;  3S3H A;  2QBS A;  5K25 A;  3B7O A;  1G4U S;  4D3Q A;  2M3V A;  2CM3 A;  3QCD A;  2HNQ A;  2WGP A;  1EEO A;  5M43 A;  3EMU A;  4H1O A;  5AWX A;  1YGU A;  5KA9 A;  1YFO A;  3EAX A;  2I4G A;  1ZC0 A;  4RI4 A;  5K22 A;  1ECV A;  2HNP A;  2H4K A;  4KYR A;  3ZV2 A;  1ZZW A;  2J16 B;  1PTT A;  3ZM2 A;  1G1F A;  2AZR A;  1T4J A;  2QCT A;  1Q1M A;  2NTA A;  1G7G A;  2MBC A;  1U24 A;  5KA2 A;  5KAA A;  3D42 A;  2F6W A;  4B04 A;  4ZI4 A;  1YTS A;  2I3U A;  4RH5 A;  2ZMM A;  5KA4 A;  1ONZ A;  4QBE A;  5KA1 A;  4RI5 A;  4QBW A;  3V0F A;  2OZ5 A;  4TVV A;  3BM8 A;  2B4P A;  1L8G A;  4Y2E A;  5BUG A;  1BZH A;  1C84 A;  1FQ1 A;  1LQF A;  2NZ6 A;  3I36 A;  4JMK A;  2QDM A;  1G1H A;  3I80 A;  2VEY A;  5KAB A;  3AWE A;  4ZN5 A;  4ZRT A;  3QCL A;  3QCF A;  3O4T A;  3QCK A;  3EZZ A;  4BPC A;  1G4W R;  3QCC A;  1XBO A;  2G59 A;  3N0A A;  1KAK A;  1OES A;  4NX8 A;  2R0B A;  3D1O A;  1RPM A;  3V0I A;  5IBM A;  4IKC A;  4BJO A;  4OHL A;  2F70 A;  2CJZ A;  2H04 A;  3D44 A;  3F9A A;  1PXH A;  3RZ2 A;  2H03 A;  2Q47 A;  3D1Q A;  1L8K A;  3V0H A;  3A5K A;  4JNB A;  1U26 A;  2RF6 A;  2H02 A;  3V0E A;  2CNH A;  2PQ5 A;  3QCG A;  1PTU A;  3SME A;  3MOW A;  4D3P A;  3O4U A;  3BLT A;  3OLR A;  5KAC A;  2B4O A;  2B4S A;  4GRZ A;  3QKP A;  2F46 A;  5EHR A;  3EB1 A;  2CNE A;  2QDP A;  2I1Y A;  3ZMP A;  2HVL A;  2GJT A;  1PA9 A;  3D1H A;  5KA8 A;  4NYH A;  1PTV A;  1Q6S A;  3EU0 A;  4DGX A;  2I6M A;  4Y14 A;  2VEW A;  4YAA A;  5K9V A;  1VHR A;  4GE2 A;  5K9W A;  1G1G A;  4GE6 A;  3S4O A;  2F6V A;  2OOQ A;  4WOH A;  2VEX A;  1C88 A;  4RHG A;  4ERC A;  5HDE A;  1OET A;  1BZC A;  1Q6P A;  4PYH A;  3I7Z A;  1YWF A;  5BZX A;  2QCJ A;  1D5R A;  2B07 A;  2FJN A;  4RDD A;  1T48 A;  2AHS A;  1X24 A;  1GWZ A;  1FPR A;  4PVG A;  3QCB A;  1FPZ A;  2I3R A;  4OHH A;  3GXG A;  5EHP A;  4S0G A;  3S3K A;  1MKP A;  1QXK A;  2BV5 A;  3O4S A;  4AZ1 A;  3F99 A;  1WCH A;  2QBP A;  2QDC A;  1YGR A;  3RGO A;  3LJ8 A;  1WRM A;  2I6O A;  2QBQ A;  2I6I A;  2F6Z A;  1Q6M A;  3BRH A;  2B49 A;  1I9S A;  3A5J A;  4QUM A;  3OMH A;  1XM2 A;  1U25 A;  3RGQ A;  1G7F A;  3BLU A;  3MOZ A;  4D3R A;  3V0G A;  3F81 A;  2CNF A;  4OHD A; 
#chains in the Genus database with same CATH topology
 3CWE A;  2ZN7 A;  2FH7 A;  1NNY A;  2JFF A;  3AWF A;  1KAV A;  2E0T A;  4Z6B A;  2HC1 A;  1V3A A;  4GFV A;  3GXH A;  4JMJ A;  1I9T A;  4ZIY A;  1YTN A;  3S4E A;  3NME A;  1T49 A;  5J8R A;  1Q6T A;  1QZ0 A;  1OHE A;  3V0J A;  1LYV A;  4HJP A;  2PA5 A;  3N2A A;  4KI9 A;  4R0T A;  5MMZ B;  3QCI A;  1OEM X;  3U96 A;  2WTZ A;  2F6T A;  2PT0 A;  2VEV A;  3ZM3 A;  1C87 A;  2CNG A;  1EEN A;  1I57 A;  3QCN A;  5LXQ B;  2BIJ A;  3H2X A;  3QCJ A;  2Q05 A;  1E0D A;  2Y67 A;  2F00 A;  2X5O A;  4C12 A;  5I6V A;  2BGE A;  2QBR A;  2B3O A;  4RKK A;  4R0S A;  4RH9 A;  5KA0 A;  3D9C A;  4I8N A;  2CM2 A;  1Q6J A;  3NRS A;  2C7S A;  4WTY A;  2Y68 A;  2CMA A;  2OUD A;  2I4H A;  1YPT A;  2GWO A;  2GC5 A;  1GQY A;  2H4G A;  2C46 A;  4OHE A;  1XXV A;  2SHP A;  1P15 A;  4NND A;  2I4E A;  4HRF A;  4ICZ A;  1C83 A;  4QF5 A;  2NV5 A;  3O3L A;  2JJD A;  1OEO X;  5KA3 A;  4MBB A;  4DGP A;  4YR8 B;  1YZ4 A;  1M3G A;  2ESB A;  5GTJ A;  2CM8 A;  2UUP A;  4HJQ A;  1O5Z A;  2NLK A;  5BZZ A;  1C86 A;  2HY3 A;  2CFV A;  2Y96 A;  2QEP A;  3QCZ A;  3SR9 A;  2NT2 A;  1ZCK A;  2CM7 A;  4H34 A;  4R30 A;  2HC2 A;  3QCH A;  2HCM A;  2VOS A;  3RO1 A;  4QUN A;  2P4D A;  1YN9 A;  3O5X A;  1Q6N A;  3QCE A;  2JFG A;  2P6X A;  1JF7 A;  1JBV A;  2F6Y A;  4JBC A;  3ZM1 A;  2Y2F A;  3PYZ A;  3QCM A;  1AAX A;  2CMC A;  4BUC A;  2HXP A;  2PI7 A;  3ZM0 A;  2AM1 A;  4GS0 A;  2I42 A;  2HB1 A;  2I6J A;  1PYN A;  4QAP A;  4OHI A;  1OHD A;  1NWE A;  4GFU A;  1R6H A;  2B4U A;  2FJM A;  4HV4 A;  1YTW A;  4GE5 A;  1WAX A;  2DXP A;  2I5X A;  4NWG A;  4J51 A;  1LAR A;  1BZJ A;  2J16 A;  5K24 A;  2H4V A;  1GFY A;  2I75 A;  3F41 A;  4GWF A;  1OHC A;  1NO6 A;  5BX1 A;  1OEV A;  2OC3 A;  2GP0 A;  1PA1 A;  2GC6 A;  1J6U A;  4QAH A;  3CM3 A;  2J17 A;  5IBS A;  3V0D A;  1PH0 A;  5KA7 A;  2XJA A;  1UAG A;  3S3E A;  1A5Y A;  3MMJ A;  4CVL A;  1OEU A;  2BGD A;  4UAG A;  1JBW A;  1C85 A;  2VEU A;  4WU2 A;  3ZMQ A;  1XXP A;  2GCA A;  1J4X A;  2IMG A;  3F9B A;  4KYQ A;  1XRI A;  1NWL A;  2F6F A;  2G6Z A;  2F71 A;  3ZM6 A;  1ZCL A;  2A8B A;  1PTY A;  3QKQ A;  4WU3 A;  5KAD A;  2CMB A;  1RXD A;  4GRY A;  3AWG A;  3M4U A;  4CVK A;  2NT7 A;  3PS5 A;  4NWF A;  1JLN A;  2A3K A;  5K23 A;  2CNI A;  1NZ7 A;  1ONY A;  3S3F A;  2PBN A;  2I6P A;  3LK7 A;  1NL9 A;  2BZL A;  2YDU A;  3ZL8 A;  2PSZ A;  1SUG A;  3S3H A;  2QBS A;  5K25 A;  3B7O A;  1G4U S;  4D3Q A;  2M3V A;  2CM3 A;  3QCD A;  2HNQ A;  2WGP A;  1EEO A;  5M43 A;  3EMU A;  4H1O A;  5AWX A;  1YGU A;  5KA9 A;  1YFO A;  3EAX A;  2I4G A;  1ZC0 A;  4RI4 A;  5K22 A;  1ECV A;  2HNP A;  2H4K A;  4KYR A;  3ZV2 A;  1ZZW A;  2J16 B;  1PTT A;  3MVN A;  2XPC A;  3ZM2 A;  1G1F A;  2AZR A;  1T4J A;  2QCT A;  1Q1M A;  2NTA A;  1G7G A;  2MBC A;  1U24 A;  2VTE A;  5KA2 A;  5KAA A;  3D42 A;  2F6W A;  4B04 A;  4ZI4 A;  3HN7 A;  1YTS A;  2AM2 A;  2I3U A;  4RH5 A;  2ZMM A;  5KA4 A;  1ONZ A;  4QBE A;  5KA1 A;  4RI5 A;  4QBW A;  4QDI A;  3V0F A;  2OZ5 A;  4TVV A;  3BM8 A;  2B4P A;  1L8G A;  4Y2E A;  5BUG A;  1BZH A;  4CVM A;  1P31 A;  1C84 A;  1FQ1 A;  1LQF A;  2NZ6 A;  3I36 A;  4JMK A;  2QDM A;  1G1H A;  3I80 A;  2VEY A;  5KAB A;  3AWE A;  4ZN5 A;  4ZRT A;  3QCL A;  2Y66 A;  3QCF A;  1W78 A;  4C13 A;  3O4T A;  3QCK A;  3EZZ A;  4BPC A;  1G4W R;  3QCC A;  1XBO A;  2G59 A;  2VOR A;  3N0A A;  1KAK A;  2VTD A;  1OES A;  4NX8 A;  2R0B A;  2UAG A;  3D1O A;  1RPM A;  3V0I A;  5IBM A;  4IKC A;  4BJO A;  4OHL A;  2F70 A;  2CJZ A;  1GG4 A;  2H04 A;  3D44 A;  3F9A A;  1PXH A;  3RZ2 A;  2H03 A;  2Q47 A;  3D1Q A;  1L8K A;  3V0H A;  2Y1O A;  3A5K A;  4JNB A;  1U26 A;  2RF6 A;  2H02 A;  3V0E A;  2CNH A;  2PQ5 A;  1GQQ A;  1EEH A;  3QCG A;  3UAG A;  1PTU A;  3SME A;  1E8C A;  3MOW A;  4D3P A;  3O4U A;  3BLT A;  3OLR A;  5KAC A;  2B4O A;  2B4S A;  4GRZ A;  3QKP A;  2F46 A;  5EHR A;  3EB1 A;  2CNE A;  2QDP A;  2I1Y A;  3ZMP A;  2HVL A;  2GJT A;  1PA9 A;  3D1H A;  5KA8 A;  4NYH A;  1PTV A;  1Q6S A;  3EU0 A;  4DGX A;  2I6M A;  4Y14 A;  2VEW A;  4YAA A;  5K9V A;  1VHR A;  4GE2 A;  5K9W A;  1G1G A;  4GE6 A;  3S4O A;  5A5F A;  2F6V A;  2OOQ A;  4WOH A;  2VEX A;  1FGS A;  1C88 A;  4RHG A;  4ERC A;  5HDE A;  1OET A;  1BZC A;  1Q6P A;  2UUO A;  4PYH A;  3I7Z A;  1YWF A;  5BZX A;  2QCJ A;  1D5R A;  2B07 A;  2FJN A;  4RDD A;  1W7K A;  1T48 A;  2AHS A;  1X24 A;  1GWZ A;  2JFH A;  1FPR A;  4PVG A;  3QCB A;  1FPZ A;  2I3R A;  4OHH A;  3GXG A;  5EHP A;  4S0G A;  3S3K A;  1MKP A;  1QXK A;  2BV5 A;  3O4S A;  4AZ1 A;  3F99 A;  1WCH A;  4BUB A;  2QBP A;  2QDC A;  1YGR A;  3RGO A;  3LJ8 A;  1WRM A;  2I6O A;  2QBQ A;  2I6I A;  2GCB A;  5A5E A;  2F6Z A;  1Q6M A;  3BRH A;  2B49 A;  1I9S A;  3A5J A;  4QUM A;  3OMH A;  1P3D A;  1XM2 A;  1U25 A;  3RGQ A;  1G7F A;  3ZM5 A;  3BLU A;  3MOZ A;  4D3R A;  3V0G A;  3F81 A;  2CNF A;  2WJP A;  4OHD A; 
#chains in the Genus database with same CATH homology
 3CWE A;  2ZN7 A;  2FH7 A;  1NNY A;  3AWF A;  1KAV A;  2E0T A;  4Z6B A;  2HC1 A;  1V3A A;  4GFV A;  3GXH A;  4JMJ A;  1I9T A;  1YTN A;  3S4E A;  3NME A;  1T49 A;  5J8R A;  1Q6T A;  1QZ0 A;  1OHE A;  3V0J A;  1LYV A;  4HJP A;  2PA5 A;  4KI9 A;  4R0T A;  5MMZ B;  3QCI A;  1OEM X;  3U96 A;  2F6T A;  2PT0 A;  2VEV A;  3ZM3 A;  1C87 A;  2CNG A;  1EEN A;  1I57 A;  3QCN A;  5LXQ B;  2BIJ A;  3H2X A;  3QCJ A;  2Q05 A;  5I6V A;  2BGE A;  2QBR A;  2B3O A;  4RKK A;  4R0S A;  4RH9 A;  5KA0 A;  3D9C A;  4I8N A;  2CM2 A;  1Q6J A;  4WTY A;  2C7S A;  2CMA A;  2OUD A;  2I4H A;  1YPT A;  2GWO A;  2H4G A;  2C46 A;  4OHE A;  1XXV A;  2SHP A;  1P15 A;  4NND A;  2I4E A;  4HRF A;  4ICZ A;  1C83 A;  2NV5 A;  3O3L A;  2JJD A;  1OEO X;  5KA3 A;  4MBB A;  4DGP A;  4YR8 B;  1YZ4 A;  1M3G A;  2ESB A;  5GTJ A;  2CM8 A;  4HJQ A;  2NLK A;  5BZZ A;  1C86 A;  2HY3 A;  2CFV A;  2Y96 A;  2QEP A;  3SR9 A;  2NT2 A;  1ZCK A;  2CM7 A;  4H34 A;  4R30 A;  2HC2 A;  3QCH A;  2HCM A;  3RO1 A;  4QUN A;  2P4D A;  1YN9 A;  3O5X A;  1Q6N A;  3QCE A;  2P6X A;  1JF7 A;  2F6Y A;  4JBC A;  3ZM1 A;  2Y2F A;  3QCM A;  1AAX A;  2CMC A;  2HXP A;  2PI7 A;  3ZM0 A;  4GS0 A;  2I42 A;  2HB1 A;  2I6J A;  1PYN A;  4QAP A;  4OHI A;  1OHD A;  1NWE A;  4GFU A;  1R6H A;  2B4U A;  2FJM A;  1YTW A;  4GE5 A;  1WAX A;  2DXP A;  2I5X A;  4NWG A;  4J51 A;  1LAR A;  1BZJ A;  2J16 A;  5K24 A;  2H4V A;  1GFY A;  2I75 A;  3F41 A;  4GWF A;  1OHC A;  1NO6 A;  5BX1 A;  1OEV A;  2OC3 A;  2GP0 A;  1PA1 A;  4QAH A;  3CM3 A;  2J17 A;  5IBS A;  3V0D A;  1PH0 A;  5KA7 A;  3S3E A;  1A5Y A;  3MMJ A;  1OEU A;  2BGD A;  1C85 A;  2VEU A;  4WU2 A;  3ZMQ A;  1XXP A;  1J4X A;  2IMG A;  3F9B A;  4KYQ A;  1XRI A;  1NWL A;  2F6F A;  2G6Z A;  2F71 A;  1ZCL A;  2A8B A;  1PTY A;  3QKQ A;  4WU3 A;  5KAD A;  2CMB A;  1RXD A;  4GRY A;  3AWG A;  3M4U A;  3PS5 A;  2NT7 A;  4NWF A;  1JLN A;  2A3K A;  5K23 A;  2CNI A;  1NZ7 A;  1ONY A;  3S3F A;  2PBN A;  2I6P A;  1NL9 A;  2BZL A;  2YDU A;  2PSZ A;  1SUG A;  3S3H A;  2QBS A;  5K25 A;  3B7O A;  1G4U S;  4D3Q A;  2M3V A;  2CM3 A;  3QCD A;  2HNQ A;  2WGP A;  1EEO A;  5M43 A;  3EMU A;  4H1O A;  5AWX A;  1YGU A;  5KA9 A;  1YFO A;  3EAX A;  2I4G A;  1ZC0 A;  4RI4 A;  5K22 A;  1ECV A;  2HNP A;  2H4K A;  4KYR A;  3ZV2 A;  1ZZW A;  2J16 B;  1PTT A;  3ZM2 A;  1G1F A;  2AZR A;  1T4J A;  2QCT A;  1Q1M A;  2NTA A;  1G7G A;  2MBC A;  1U24 A;  5KA2 A;  5KAA A;  3D42 A;  2F6W A;  4B04 A;  4ZI4 A;  1YTS A;  2I3U A;  4RH5 A;  2ZMM A;  5KA4 A;  1ONZ A;  4QBE A;  5KA1 A;  4RI5 A;  4QBW A;  3V0F A;  2OZ5 A;  4TVV A;  3BM8 A;  2B4P A;  1L8G A;  4Y2E A;  5BUG A;  1BZH A;  1C84 A;  1FQ1 A;  1LQF A;  2NZ6 A;  3I36 A;  4JMK A;  2QDM A;  1G1H A;  3I80 A;  2VEY A;  5KAB A;  3AWE A;  4ZN5 A;  4ZRT A;  3QCL A;  3QCF A;  3O4T A;  3QCK A;  3EZZ A;  4BPC A;  1G4W R;  3QCC A;  1XBO A;  2G59 A;  3N0A A;  1KAK A;  1OES A;  4NX8 A;  2R0B A;  3D1O A;  1RPM A;  3V0I A;  5IBM A;  4IKC A;  4BJO A;  4OHL A;  2F70 A;  2CJZ A;  2H04 A;  3D44 A;  3F9A A;  1PXH A;  3RZ2 A;  2H03 A;  2Q47 A;  3D1Q A;  1L8K A;  3V0H A;  3A5K A;  4JNB A;  1U26 A;  2RF6 A;  2H02 A;  3V0E A;  2CNH A;  2PQ5 A;  3QCG A;  1PTU A;  3SME A;  3MOW A;  4D3P A;  3O4U A;  3BLT A;  3OLR A;  5KAC A;  2B4O A;  2B4S A;  4GRZ A;  3QKP A;  2F46 A;  5EHR A;  3EB1 A;  2CNE A;  2QDP A;  2I1Y A;  3ZMP A;  2HVL A;  2GJT A;  1PA9 A;  3D1H A;  5KA8 A;  4NYH A;  1PTV A;  1Q6S A;  3EU0 A;  4DGX A;  2I6M A;  4Y14 A;  2VEW A;  4YAA A;  5K9V A;  1VHR A;  4GE2 A;  5K9W A;  1G1G A;  4GE6 A;  3S4O A;  2F6V A;  2OOQ A;  4WOH A;  2VEX A;  1C88 A;  4RHG A;  4ERC A;  5HDE A;  1OET A;  1BZC A;  1Q6P A;  4PYH A;  3I7Z A;  1YWF A;  5BZX A;  2QCJ A;  1D5R A;  2B07 A;  2FJN A;  4RDD A;  1T48 A;  2AHS A;  1X24 A;  1GWZ A;  1FPR A;  4PVG A;  3QCB A;  1FPZ A;  2I3R A;  4OHH A;  3GXG A;  5EHP A;  4S0G A;  3S3K A;  1MKP A;  1QXK A;  2BV5 A;  3O4S A;  4AZ1 A;  3F99 A;  1WCH A;  2QBP A;  2QDC A;  1YGR A;  3RGO A;  3LJ8 A;  1WRM A;  2I6O A;  2QBQ A;  2I6I A;  2F6Z A;  1Q6M A;  3BRH A;  2B49 A;  1I9S A;  3A5J A;  4QUM A;  3OMH A;  1XM2 A;  1U25 A;  3RGQ A;  1G7F A;  3BLU A;  3MOZ A;  4D3R A;  3V0G A;  3F81 A;  2CNF A;  4OHD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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